CN101810795B - Composition of traditional Chinese medicinal extract for preventing damage of environmental pollutants as well as preparation method and application thereof - Google Patents
Composition of traditional Chinese medicinal extract for preventing damage of environmental pollutants as well as preparation method and application thereof Download PDFInfo
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- CN101810795B CN101810795B CN2010101460305A CN201010146030A CN101810795B CN 101810795 B CN101810795 B CN 101810795B CN 2010101460305 A CN2010101460305 A CN 2010101460305A CN 201010146030 A CN201010146030 A CN 201010146030A CN 101810795 B CN101810795 B CN 101810795B
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Abstract
The invention relates to a composition of a traditional Chinese medicinal extract for preventing the damage of environmental pollutants, comprising the following components in percentage by weight: 1-20 percent of ginkgo leaf, 1-20 percent of liquorice, 1-20 percent of white mulberry root-bark, 1-20 percent of figwort root, 1-20 percent of cassia seed, 1-20 percent of herba pyrolae and 1-20 percent of reed rhizome. The preparation method comprises the following steps of: soaking a traditional Chinese prescription with alcohol to obtain soaking liquid, wherein the consumption of the alcohol for soaking is 20-300 times the weight of the traditional Chinese prescription; filtering and condensing the soaking liquid by 10-50 times; adsorbing a condensing liquid with macroporous resin; eluting with 10-98 percent alcohol multiple times; and collecting elution containing compositions of various traditional Chinese medicinal extracts. Compared with the like products, the invention has remarkable effect and the characteristics of double actions for inhibiting melanin and promoting the regeneration of skin cell and favorable safety.
Description
Technical field
The present invention relates to a kind of compositions and method for making and purposes of Chinese medicine extract of the thing injury that prevents the pollution of the environment; This Chinese medicine composition is made up of the extract of Folium Ginkgo, Radix Glycyrrhizae, Cortex Mori, Radix Scrophulariae, Semen Cassiae, Herba Pyrolae and Rhizoma Phragmitis, can be used for the cosmetics and the medicine of skin nursing.
Background technology
Along with the quickening of urban industry process, problem of environmental pollution is serious day by day, and environmental contaminants more and more cause people's attention to the mankind's injury.Nearest scientific research proves that one of topmost pollutant are exactly diox in the environment at present, and this material receives extensive concern to the injury effect of human health.But, mainly still adopt physically-isolated mode for the protective action of this material.From biomedical angle its method of protecting still is in the blank stage.
Folium Ginkgo is a kind of plant with very high medical value; Be used for cough and asthma due to lung deficiency, the ability blood circulation promoting, Prevention of Cardiovascular is sick; Semen Ginkgo extrac has very strong removing free radical and antioxidation; The synthetic collagen protein composition of flavonoid glycoside in the Folium Ginkgo, aminoacid and aminoacid is improved looks to human body, suppresses the melanin growth, keeps skin gloss and elasticity to play no small effect.
Radix Glycyrrhizae is of many uses, and northern clinical application relaxes in moistening in the traditional Chinese medical science, the strong medicine that neutralizes, and detoxifcation, analgesia, spasmolytic, relieving cough and expelling phlegm etc., so that have anticancer pharmacological action.Give birth to curing mainly laryngopharynx swelling and pain, cellulitis, skin infection, ulcer, and detoxifcation etc.; Processed with honey cures mainly spleen and stomach function and goes down, heating cardiopalmus etc.
Cortex Mori is mainly used in the lung-heat cough with asthma, the edema of the face, and diseases such as dysuria, its pharmacological action also comprises blood sugar lowering, blood pressure lowering and effect such as antibiotic.Clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.
Radix Scrophulariae can clearing away heat and cooling blood, and YIN nourishing and the production of body fluid promoting is gone into nutrient blood with controlling heat, consumption of YIN caused by febrile disease, and cards such as interior-heat caused by deficiency of YIN, and Radix Scrophulariae eliminating fire and detoxication power is stronger, so laryngopharynx swelling and pain, the phlegm-fire scrofula is used more.
Semen Cassiae has the merit that makes eye bright with it and is well-known, but liver heat removing and eyesight improving, and the diuretic relieving constipation has laxative action, reducing blood pressure and blood fat.
Herba Pyrolae is used for rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Rhizoma Phragmitis has clearing away heat and promoting production of body fluid, relieving restlessness, and preventing or arresting vomiting, the diuretic effect can be used for being used for the calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria etc.
Above-mentioned Chinese medicine all is to be used for eating or being used as medicine traditionally, replenishes the needed by human body nutrient, or plays the effect of regulating human mechanism.The compositions of above-mentioned each Chinese medicine extract is not in the news up to now as yet, except that Folium Ginkgo, and has not had other Chinese medicines of open file announcement to can be used for skin nursing.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions of Chinese medicine extract of the thing injury that prevents the pollution of the environment, and the said composition reliable effect has and suppresses melanin and the dual function that promotes that Skin Cell is newborn.
Another technical problem to be solved by this invention is to provide the preparation of compositions method of the Chinese medicine extract of the above-mentioned thing injury that prevents the pollution of the environment.
A technical problem more to be solved by this invention is to provide the purposes of compositions of the Chinese medicine extract of the above-mentioned thing injury that prevents the pollution of the environment, and is used for skin nursing products.
The present invention solves the problems of the technologies described above the technical scheme of being taked: a kind of compositions of Chinese medicine extract of the thing injury that prevents the pollution of the environment; Wherein, Described compositions is made up of the extract of Chinese medicine Folium Ginkgo, Radix Glycyrrhizae, Cortex Mori, Radix Scrophulariae, Semen Cassiae, Herba Pyrolae and Rhizoma Phragmitis, and the quality percentage composition of arbitrary component all is no more than 20% of total amount.
The present invention adopts the composition in China's Chinese medicine to make up and observes the protective effect that these Chinese medicine composition injure to environmental pollutants.Scientific research according to nearest proves that the De diox is mainly acting through the aryl hydrocarbon receptor that influences in the biological cell in the environmental contaminants.The two kind passage cells of the present invention through having aryl hydrocarbon receptor are observed the Chinese medicine extract combination of the present invention protective effect of injury to environmental pollutants as test model.The result shows that Chinese medicine extract combination of the present invention has the effect of the thing pair cell injury that prevents the pollution of the environment really.
On the basis of such scheme, by weight percentage, the content of said each Chinese medicine extract is: Folium Ginkgo 1～20%, Radix Glycyrrhizae 1～20%, Cortex Mori 1～20%, Radix Scrophulariae 1～20%, Semen Cassiae 1～20%, Herba Pyrolae 1～20%, Rhizoma Phragmitis 1～20%.
The concrete consumption of each component can for:
Folium Ginkgo 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Radix Glycyrrhizae 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Cortex Mori 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Radix Scrophulariae 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Semen Cassiae 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Herba Pyrolae 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Rhizoma Phragmitis 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%.
On the basis of such scheme; By weight percentage, the preferred content of said each Chinese medicine extract is: Folium Ginkgo 2～15%, Radix Glycyrrhizae 2～15%, Cortex Mori 2～15%, Radix Scrophulariae 2～15%, Semen Cassiae 2～15%, Herba Pyrolae 2～15%, Rhizoma Phragmitis 2～15%.
Should be pointed out that the percentage composition of each Chinese medicine extract among the present invention is that dry weight with compositions is a benchmark, but what in the preparation process, often obtain is the solution that comprises said composition.
Preparation of compositions method to the Chinese medicine extract of the above-mentioned thing injury that prevents the pollution of the environment comprises the steps:
The first step: with above-mentioned Chinese prescription with 20%～80% alcohol-pickled, soak the ethanol consumption uses and be Chinese prescription weight 20～300 times, must soak;
Second step: soak concentrates 10～50 times after filtering, and concentrated solution is used macroporous resin adsorption, and the ethanol of reuse mass concentration 10%～98% is eluting repeatedly, collects eluent, comprises the compositions of Chinese medicine extract in the eluent.
Concrete, the ethanol consumption that soaks usefulness can be 20,22,25,28,30,32,35,38,40,42,45,48,50,60,80,100 of Chinese medicinal components gross weight, 120,150,180,200,220,250,280 or 300 times; Soak can concentrate 10,15,20,25,30,35,40,45 or 50 times after filtering.
On the basis of such scheme, in the first step, described alcohol-pickled for Chinese prescription with alcohol-pickled 2～48 hours; Or be that Chinese prescription is first with alcohol-pickled 2～48 hours, alcohol-pickled 2～48 hours of residue reuse merges the solution after soaking.
On the basis of such scheme, in second step, it is 50%～90% that said eluting uses the mass concentration of ethanol.
The purposes of the compositions of the Chinese medicine extract that the thing that prevents the pollution of the environment that makes to said method injures is used to prepare skin care cosmetics or medicine, comprises cream, emulsion, astringent, gel, facial film, inuncts and lotion.
On the basis of such scheme; The extracting solution compositions that makes through being evaporated to 1/2～1/5 of former weight, is obtained composition concentrated solution, be used to prepare skin care cosmetics or medicine; Mix mutually with the substrate of known cosmetics and medicine or adjuvant, carrier, additive; Method according to routine prepares, and wherein, said composition concentrated solution accounts for 5～10% of skin care cosmetics or medicine gross weight.
Concrete, composition concentrated solution can account for 5,6,7,8,9 or 10% of gross weight.
The invention has the beneficial effects as follows:
The compositions of the resulting Chinese medicine extract of the present invention has the effect that the thing that prevents the pollution of the environment injures through evidence, can be used in the cosmetics and the curative drug of skin care; Related composition has that effect is clear and definite, safety good, without any side effects and in cosmetic formulations stable characteristics; Compare with existing like product have effect obviously, have and suppress melanin and promote dual function and the good characteristics of safety that Skin Cell is newborn.
The specific embodiment
Embodiment 1
At room temperature; Get Folium Ginkgo, Radix Glycyrrhizae, Cortex Mori, Radix Scrophulariae, Semen Cassiae, Herba Pyrolae and Rhizoma Phragmitis each 10 kilograms (totally 70 kilograms), 1200 kilograms of soak times of ethanol of use 50% are 24 hours, and the ethanol of residue reuse 50% soaked 24 hours for 1200 kilograms; Solution after will soaking then merges; Through concentrating 20 times behind the 200 purpose strainer filterings, again with macroporous resin on the concentrated solution, with 40% ethanol eluting; Contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of Chinese medicine extract.
Embodiment 2
At room temperature; Get Folium Ginkgo, Radix Glycyrrhizae, Cortex Mori, Radix Scrophulariae, Semen Cassiae, Herba Pyrolae and Rhizoma Phragmitis each 10 kilograms (totally 70 kilograms), 1500 kilograms of soak times of ethanol of use 80% are 40 hours, and the ethanol of residue reuse 80% soaked 40 hours for 1500 kilograms; The solution of the solution after will soaking then merges; Through concentrating 30 times behind the 200 purpose strainer filterings, again with macroporous resin on the concentrated solution, with 70% ethanol eluting; Contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of Chinese medicine extract.
Embodiment 3
At room temperature; Get 5 kilograms of Folium Ginkgos, 7 kilograms in Radix Glycyrrhizae, 10 kilograms of Cortex Mori, 10 kilograms of Radix Scrophulariaes, 12 kilograms of Semen Cassiaes, 12 kilograms of Herba Pyrolaes and 14 kilograms of Rhizoma Phragmitiss (totally 70 kilograms), 1000 kilograms of soak times of ethanol of use 60% are 24 hours, and the ethanol of residue reuse 60% soaked 24 hours for 1000 kilograms; The solution of the solution after will soaking then merges; Through concentrating 30 times behind the 200 purpose strainer filterings, again with macroporous resin on the concentrated solution, the ethanol eluting with 80%; Contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of Chinese medicine extract.
Embodiment 4
At room temperature; Get 8 kilograms of Folium Ginkgos, 12 kilograms in Radix Glycyrrhizae, 8 kilograms of Cortex Mori, 12 kilograms of Radix Scrophulariaes, 10 kilograms of Semen Cassiaes, 12 kilograms of Herba Pyrolaes and 8 kilograms of Rhizoma Phragmitiss (totally 70 kilograms), 1800 kilograms of soak times of ethanol of use 30% are 48 hours, through concentrating 20～30 times behind the 200 purpose strainer filterings; Again with macroporous resin on the concentrated solution; Ethanol eluting with 70%～90% contains needed effective ingredient in the prescription of the present invention, i.e. the compositions of Chinese medicine extract in the eluent of collection.
Application examples
The liquid that embodiment 2 is obtained adopts concentrating under reduced pressure, is concentrated into 1/2nd to 1/5th of former weight, gets the composition concentrated solution of Chinese medicine extract, is used for preparation protection cream, and prescription of this protection cream is as shown in table 1.
Table 1
Production technology:
The first step: HANSHENGJIAO is dispersed in the deionized water, and elevated temperature to 80 ℃ simultaneously, adds other components of B phase then, stir;
Second step: each component of A phase is complete in 80 ℃ of dissolvings, stir; A is added to middle mutually homogenizing, about 4 minutes of stirring of B;
The 3rd step: add C and stirred fast mutually 1～2 minute, froth breaking is cooled to 65 ℃;
The 4th step: add the D phase, back to the 40 ℃ of addings that stir comprise each component of E phase of composition concentrated solution, the discharging that stirs, and pH value is controlled at 4.0～5.0, makes the protection cream.
The prevent the pollution of the environment test report of thing injury of Chinese prescription
Explain:
One, the compositions of used Chinese medicine extract is the compositions of the Chinese medicine extract of weaving damage of environmental pollutants of the present invention in the following test;
Two, used 2,3,7 in the test, 8-tetrachloro dibenzo Dui bioxin (TCDD) is the reference material as the hostile environment pollutant;
Three, inductive Cytotoxic inhibitory action test is used to observe the prevent the pollution of the environment effect of thing injury of composition described herein to the compositions of Chinese medicine extract to TCDD:
1. reagent and method
1.1 reagent: 2,3,7,8-tetrachloro dibenzo Dui bioxin (TCDD), dimethyl sulfoxide (DMSO) are provided by SIGMA;
Human liver cell tumor TV101L cell, mouse liver cell tumor Hep2a1112CR cell are provided by Chinese Academy of Sciences's Shanghai cell biological institute.
1.2 method: adopt chemokinesis luciferase expression (CALux) method, isolated measuring is tried thing and induces gene expression and the Chinese medicine extract that AhR relies in the intact cell to make up the inhibitory action to it.
1.2.1 human liver cell tumor TV101L cellular exposure is in 10
-13～10
-6Mol 2,3, and 7; In 8-tetrachloro dibenzo Dui bioxin (TCDD) and 0.005% dimethyl sulfoxide (DMSO), test hole adds the Chinese medicine extract combination, and control wells adds culture fluid; Behind the 24h; Measure its uciferase activity, the protein content of measuring cell simultaneously is to proofread and correct cell number, and uciferase activity is with light quantity unit (Rlu/ μ g) expression relatively in every microgram albumen.
1.2.2 mouse liver cell tumor Hep2a1112CR cell grows in the MEM culture fluid that contains calf serum, gentamycin and G418, cells contacting 0.005%DMSO, 10
-12～10
-8Behind the mol TCDD 4h, measure uciferase activity (Rlu/ μ g).
2. result: the compositions of Chinese medicine extract is as shown in table 2 to the inductive Cytotoxic inhibitory action of TCDD.
Table 2
Result of the test shows that environment noxious pollutant TCDD has significant cytotoxicity, and Chinese medicine extract combination used herein can effectively suppress the cytotoxic effect of TCDD.
Claims (8)
1. thing injury and be used for the compositions of the Chinese medicine extract of skin care of preventing the pollution of the environment; It is characterized in that: described compositions is made up of the extract of Chinese medicine Folium Ginkgo, Radix Glycyrrhizae, Cortex Mori, Radix Scrophulariae, Semen Cassiae, Herba Pyrolae and Rhizoma Phragmitis, and the quality percentage composition of arbitrary component all is no more than 20% of total amount.
2. the thing that prevents the pollution of the environment according to claim 1 injures and is used for the compositions of the Chinese medicine extract of skin care; It is characterized in that: by weight percentage, the content of said each Chinese medicine extract is: Folium Ginkgo 1～20%, Radix Glycyrrhizae 1～20%, Cortex Mori 1～20%, Radix Scrophulariae 1～20%, Semen Cassiae 1～20%, Herba Pyrolae 1～20%, Rhizoma Phragmitis 1～20%.
3. the thing that prevents the pollution of the environment according to claim 2 injures and is used for the compositions of the Chinese medicine extract of skin care; It is characterized in that: by weight percentage, the content of said each Chinese medicine extract is: Folium Ginkgo 2～15%, Radix Glycyrrhizae 2～15%, Cortex Mori 2～15%, Radix Scrophulariae 2～15%, Semen Cassiae 2～15%, Herba Pyrolae 2～15%, Rhizoma Phragmitis 2～15%.
4. injure and be used for the preparation of compositions method of the Chinese medicine extract of skin care to the described thing that prevents the pollution of the environment of one of claim 1 to 3, it is characterized in that comprising the steps:
The first step: with above-mentioned Chinese prescription with 20%～80% alcohol-pickled, soak the ethanol consumption uses and be Chinese prescription weight 20～300 times, must soak;
Second step: soak concentrates 10～50 times after filtering, and concentrated solution is used macroporous resin adsorption, and the ethanol of reuse mass concentration 10%～98% is eluting repeatedly, collects eluent, comprises the compositions of Chinese medicine extract in the eluent.
5. the thing injury and be used for the preparation of compositions method of the Chinese medicine extract of skin care of preventing the pollution of the environment according to claim 4 is characterized in that: in the first step, described alcohol-pickled for Chinese prescription with alcohol-pickled 2～48 hours; Or be that Chinese prescription is first with alcohol-pickled 2～48 hours, alcohol-pickled 2～48 hours of residue reuse merges the solution after soaking.
6. the thing that prevents the pollution of the environment according to claim 4 injures and be used for the preparation of compositions method of the Chinese medicine extract of skin care, it is characterized in that: in second step, it is 40%～90% that said eluting uses the mass concentration of ethanol.
7. the thing injury and be used for the purposes of compositions of the Chinese medicine extract of skin care of preventing the pollution of the environment that makes to the said method of one of claim 4 to 6; Be used to prepare skin care cosmetics or medicine, comprise cream, emulsion, astringent, gel, facial film, inuncts and lotion.
8. the thing injury and be used for the purposes of compositions of the Chinese medicine extract of skin care of preventing the pollution of the environment according to claim 7; It is characterized in that: with the extracting solution compositions that makes through being evaporated to 1/2～1/5 of former weight; Obtain composition concentrated solution; Be used to prepare skin care cosmetics or medicine, wherein, said composition concentrated solution accounts for 5～10% of cosmetics or medicine gross weight.
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| CN102631301B (en) * | 2012-04-19 | 2014-03-26 | 扬州十二粉黛生物工程有限公司 | Luffa aqueous solution |
| CN103462861A (en) * | 2013-09-30 | 2013-12-25 | 陶坤秀 | Facial mask for resisting skin aging and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557450A (en) * | 2004-02-10 | 2004-12-29 | 张惠兰 | Chinese medicinal preparation for treating infant tracheitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557450A (en) * | 2004-02-10 | 2004-12-29 | 张惠兰 | Chinese medicinal preparation for treating infant tracheitis |
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Address after: 200444 Shanghai city Baoshan District City Bank Road No. 121 Patentee after: Shanghai Inoherb Cosmetic Co., Ltd. Address before: 200083 Shanghai City No. 1 Lane 66 Huayuan Road Jiahe International Building 18-19 Patentee before: Shanghai Inoherb Cosmetic Co., Ltd. |