CN102793643B - Chinese medical extract composition with skin aging resisting effect and preparation method and application thereof - Google Patents
Chinese medical extract composition with skin aging resisting effect and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medical extract composition with a skin aging resisting effect and a preparation method and an application thereof. The composition consists of extracts of Chinese medicines including ginkgo nut, grapefruit pip, soya bean, pagoda tree pod, sea buckthorn seed, barbary wolfberry fruit, Chinese magnoliavine fruit, walnut kernel and tartary buckwheat, wherein the content of each Chinese medicinal extract is 1-20 percent by weight. The preparation method comprises the following steps of: soaking and extracting the Chinese medicines with 20-80 percent alcohol in an amount which is 5-20 times that of the total weight of the Chinese medicines to obtain an extracting solution; filtering the extracting solution, concentrating by 10-50 times, and adsorbing and purifying a concentrated solution with macroporous adsorption resin; and repeatedly eluting with alcohol of which the mass concentration is 10-95 percent, and collecting eluents which contain the composition of each Chinese medicinal extract. The Chinese medical extract composition is used for preparing cosmetics or medicaments for resisting skin aging, such as cream, emulsions, astringent and facial masks. The prepared composition can be used for delaying aging of the skin in multiple ways and has various acting means, so that the composition can play a role in effectively resisting aging of the skin.
Description
Technical field
The present invention relates to a kind of Chinese medicine extraction compositions with anti aging effect effect, the Preparation Method And The Use that also relates to said composition, this Chinese medicine composition is made up of the extract of ginkgo nut, Semen Vitis viniferae, Semen sojae atricolor, the Fructus Sophorae, seed of Fructus Hippophae, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Juglandis and Radix Et Rhizoma Fagopyri Tatarici, can be used for skin nursing, especially the anti aging effect cosmetics.
Background technology
Anti aging effect is the most important theme of skin protection.Modern beauty medical science shows, the aging of skin is the result of multiple internal and external factor comprehensive function, and the branch of photoaging and natural aging is arranged.The approach of its slow down aging has multiple, as, remove excessive free radical, promote cell metabolism, replenishing collagen and elastin laminin, the defence ultraviolet is preserved moisture and is repaired the barrier function of skin, strengthens skin defence and immune system etc.But, the antisenility cosmetics additive that in product, adopts at present, the approach of its slow down aging is single relatively, focuses mostly on aspect first three, and its additive also lacks the integrated use of each approach.
Along with the raising of people's living standard and the progress of human medical and health care system, people are also more and more higher to the requirement of anti-aging cosmetics.Except the above-mentioned three big approach that can solve the most of problem of old and feeble skin, it is to be strengthened to also have many aspects to have, and as suppressing dull-looking skin, puies forward the bright colour of skin, dispel macula lutea, senile plaque etc., poison reaction by inhibition non-enzymatic glycation and carbonyl in these areas and reach effect preferably; Loss at collagen protein and elastin laminin, the method that adopts mainly is to replenish the polypeptide of small-molecular weight from the external world now, it is synthetic to increase it, but the absorbtivity of cosmetics is limited, this method is difficult to satisfy the needs of old and feeble skin, if can suppress the active of matrix metalloproteinase or promote the activity that it presses down enzyme, then can reduce degraded and the loss of collagen protein and elastin laminin from root, prevent the generation of wrinkle, thus delaying decrepitude of skin.In addition, the general effect of single channel is still not good enough, therefore, in order to develop the more outstanding slow down aging cosmetics of effect, needs multipath integrated use better to solve the skin aging problem.
Flavone compound in the ginkgo nut can increase the content of skin hydroxyproline, makes the synthetic increase of skin collagen, thereby the corresponding raising of its content, thereby reduces the generation of wrinkle of skin.
Procyanidin in the Semen Vitis viniferae can be removed reactive oxygen free radical excessive in the skin, and protection skin is avoided ultraviolet injury, also has the effect of preserving moisture and whitening simultaneously, thereby the aging of energy multipath delaying skin.
Soybean isoflavone can effectively be removed excessive free radical, for climacteric and subsequent crowd, it can alleviate the xerosis cutis tarnish that descends and cause because of body inner estrogen level, collagen protein runs off, thinning of skin, elasticity and the degree of packing descend, and wrinkle is deepened, hyperpigmentation, skin aging symptoms such as senile plaque appearance.
Rutin flavonoid in the Fructus Sophorae can be removed excessive free radical, and has sun-proof effect.
The seed of Fructus Hippophae flavone can effectively be removed excessive free radical, the effect of going back Pear Power simultaneously.
Lycium barbarum polysaccharide can improve the SOD activity to reduce the skin peroxide injury, increases the content of skin collagen.
The Fructus Schisandrae Chinensis polysaccharide can improve the SOD activity to reduce the skin peroxide injury, and its lignan component then can reduce the degraded of collagen protein.
VE in the Semen Juglandis can remove reactive oxygen free radical excessive in the skin, and its water soluble ingredient then can increase the content of skin hydroxyproline.
Radix Et Rhizoma Fagopyri Tatarici rutin flavonoid can be removed excessive free radical.
Applicant of the present invention also disclosed a kind of compositions and law enforcement and purposes with important extract of function of anti-skin aging in its number of patent application 201010146039.6, but use therein nine flavor Chinese medicines are all inequality with the Chinese medicine that the present invention relates to.By the selection to above-mentioned these Chinese medicines, obtain its extract and be re-dubbed compositions, in the hope of energy multipath ground delaying decrepitude of skin, more effectively bring into play the effect of anti aging effect.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine extraction compositions with anti aging effect effect.
Another technical problem to be solved by this invention is to provide above-mentioned its preparation method with Chinese medicine extraction compositions of anti aging effect effect.
A technical problem more to be solved by this invention is to provide the purposes of the Chinese medicine extraction compositions with anti aging effect effect that above-mentioned preparation method makes.
The present invention solves the problems of the technologies described above the technical scheme of taking: a kind of Chinese medicine extraction compositions with anti aging effect effect, described compositions is made up of the extract of Chinese medicine ginkgo nut, Semen Vitis viniferae, Semen sojae atricolor, the Fructus Sophorae, seed of Fructus Hippophae, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Juglandis and Radix Et Rhizoma Fagopyri Tatarici, by weight percentage, described each Chinese medicine extract content is: ginkgo nut 1～20%, Semen Vitis viniferae 1～20%, Semen sojae atricolor 1～20%, the Fructus Sophorae 1～20%, seed of Fructus Hippophae 1～20%, Fructus Lycii 1～20%, Fructus Schisandrae Chinensis 1～20%, Semen Juglandis 1～20%, Radix Et Rhizoma Fagopyri Tatarici 1～20%.
Above percentage by weight is benchmark with the dry weight of Chinese medicine medical material all.
The concrete consumption of each component can for:
The consumption of ginkgo nut can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of Semen Vitis viniferae can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of Semen sojae atricolor can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of the Fructus Sophorae can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of seed of Fructus Hippophae can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of Fructus Lycii can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of Fructus Schisandrae Chinensis can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of Semen Juglandis can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%;
The consumption of Radix Et Rhizoma Fagopyri Tatarici can for: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20%.
On the basis of such scheme, by weight percentage, the preferred content of described each Chinese medicine extract is: ginkgo nut 2～15%, Semen Vitis viniferae 2～15%, Semen sojae atricolor 2～15%, the Fructus Sophorae 2～15%, seed of Fructus Hippophae 2～15%, Fructus Lycii 2～15%, Fructus Schisandrae Chinensis 2～15%, Semen Juglandis 2～15%, Radix Et Rhizoma Fagopyri Tatarici 2～15%.
Should be pointed out that the percentage composition of each Chinese medicine extract among the present invention is that dry weight with compositions is benchmark, but what often obtain is the solution that comprises said composition in preparation process.
The present invention solves the problems of the technologies described above another technical scheme of taking: the preparation method for above-mentioned composition comprises the steps:
The first step: with medicinal 20～80% alcohol-pickled extractions in above-mentioned, the ethanol consumption is 5～20 times of each Chinese medicine gross weight, gets extracting solution;
Second step: concentrate 10～50 times behind the extracting liquid filtering, concentrated solution macroporous adsorbent resin (D101) adsorption and purification;
The 3rd step: the ethanol of usefulness mass concentration 10%～95% is eluting repeatedly, collects eluent, comprises the compositions of each Chinese medicine extract in the eluent.
Concrete, the ethanol consumption can be 5,6,8,10,12,15,18,20,22,25,28,30,32,35,38,40,42,45,48 or 50 times of each Chinese medicine gross weight; Can concentrate 10,12,15,18,20,22,25,28,30,32,35,38,40,42,45,48 or 50 times after the filtration.
On the basis of such scheme, in the first step, the described alcohol-pickled time is 2～48 hours.
On the basis of such scheme, in the first step, described immersion extraction time is 1～3 time, merges each extracting solution that extracts gained that soaks.
The present invention solves the problems of the technologies described above a technical scheme again of taking: the purposes of the compositions that makes for said method, for the preparation of the cosmetics that go acne or medicine, described cosmetics or medicine are cream, emulsion, astringent or facial film.
On the basis of such scheme, the compositions that makes through being evaporated to 1/2～1/5 of former weight, is obtained composition concentrated solution, for the preparation of skin care cosmetics or medicine, wherein, described composition concentrated solution accounts for 5～10% of cosmetics or medicine gross weight.
The invention has the beneficial effects as follows:
The aging of obtained compositions energy multipath delaying skin, and action pathway variation, said composition can more effectively be brought into play the effect of anti aging effect.
The specific embodiment
Embodiment 1
At room temperature, get ginkgo nut, Semen Vitis viniferae, Semen sojae atricolor, the Fructus Sophorae, seed of Fructus Hippophae, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Juglandis, Radix Et Rhizoma Fagopyri Tatarici each 10 kilograms (totally 90 kilograms), ethanol with 50% soaked 24 hours for 1200 kilograms, the ethanol of residue reuse 50% soaked 24 hours for 1200 kilograms, to soak the gained extracting solution then merges, filter the back through 200 mesh filter screens and concentrate 20 times, with D101 macroporous resin on the concentrated solution, reuse 40% ethanol eluting, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Embodiment 2
At room temperature, get ginkgo nut, Semen Vitis viniferae, Semen sojae atricolor, the Fructus Sophorae, seed of Fructus Hippophae, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Juglandis, Radix Et Rhizoma Fagopyri Tatarici each 10 kilograms (totally 90 kilograms), ethanol with 80% soaked 20 hours for 1500 kilograms, the ethanol of residue reuse 80% soaked 20 hours for 1500 kilograms, to soak the gained extracting solution then merges, filter the back through 200 mesh filter screens and concentrate 30 times, with D101 macroporous resin on the concentrated solution, reuse 70% ethanol is eluting repeatedly, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Embodiment 3
At room temperature, get 6 kilograms of ginkgo nuts, 6 kilograms of Semen Vitis viniferae, 7 kilograms of Semen sojae atricolor, 7 kilograms of the Fructuss Sophorae, 7 kilograms of seed of Fructus Hippophae, 9.5 kilograms of Fructus Lyciis, 16 kilograms of Fructus Schisandrae Chinensis, Semen Juglandis 13.5,18 kilograms of Radix Et Rhizoma Fagopyri Tataricis (totally 90 kilograms), ethanol with 60% soaked 24 hours for 1000 kilograms, the ethanol of residue reuse 60% soaked 24 hours for 1000 kilograms, to soak the gained extracting solution then merges, filter the back through 200 mesh filter screens and concentrate 30 times, with D101 macroporous resin on the concentrated solution, reuse 80% ethanol is eluting repeatedly, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Embodiment 4
At room temperature, get 12 kilograms of ginkgo nuts, 4 kilograms of Semen Vitis viniferae, 10 kilograms of Semen sojae atricolor, 11 kilograms of the Fructuss Sophorae, 12 kilograms of seed of Fructus Hippophae, 5 kilograms of Fructus Lyciis, 12 kilograms of Fructus Schisandrae Chinensis, Semen Juglandis 12,12 kilograms of Radix Et Rhizoma Fagopyri Tataricis (totally 90 kilograms), ethanol with 30% soaked 48 hours for 18000 kilograms, filter the back through 200 mesh filter screens and concentrate 20～30 times, with D101 macroporous resin on the concentrated solution, reuse 70～90% ethanol are eluting repeatedly, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Application examples
The extractive composition that embodiment 1 is obtained adopts concentrating under reduced pressure, is concentrated into 1/2～1/5 of former weight, gets the composition concentrated solution of Chinese medicine extract, and for the preparation of the anti aging effect cream, the prescription of this anti aging effect cream is as shown in table 1.
Table 1
Production technology:
The first step: HANSHENGJIAO is dispersed in the deionized water, and the temperature to 80 ℃ of raising simultaneously, adds other components of B phase then, stir;
Second step: each component is complete in 80 ℃ of dissolvings mutually with A, stirs; A is added to B middle even matter, about 4 minutes of stirring mutually;
The 3rd step: add C and stirred fast mutually 1～2 minute, froth breaking is cooled to 65 ℃;
The 4th step: add the D phase, back to the 40 ℃ of addings that stir comprise each component of E phase of composition concentrated solution, the discharging that stirs, and pH value is controlled 4.0～5.0, makes the anti aging effect cream.
Chinese prescription is to the antioxidation of aging model mice and promote Skin Cell new life's test report:
Illustrate:
One, the compositions of used Chinese medicine extract is the compositions of delay aging drug extract of the present invention in the following test;
Two, the antioxidation test of aging model mice is used for observing the anti-aging effects of cosmetics or medicine;
Three, promote the newborn test of Skin Cell to be used for observing the defying age maintenance effect of cosmetics or medicine.
The compositions of Chinese medicine extract is to the antioxidation of aging model mice:
1. experimental animal: Kunming mouse, 10 ages in week, body weight 20～30 grams, Chinese Academy of Sciences's laboratory animal provides.
2. key instrument and reagent:
2.1 instrument: spectrofluorophotometer
Ultraviolet-visible spectrophotometer
The low-temperature and high-speed centrifuge;
2.2 reagent: vitamin E
Thiobarbituricacid (Sigma company)
Tetraethoxypropane (Fluka company)
MDA, SOD, GSH-PX, MAO-B measure test kit
3. test method: animal is divided negative (blank) matched group, positive controls, Chinese medicine experimental group; Each treated animal injection of d-galactose causes aging model, and hair is shaved at the back, and experimental group smears that compositions (5%W/W), the positive controls of Chinese medicine extract are smeared vitamin E (5%W/W), negative control group is smeared distilled water.Once a day, continuous 60 days.
4. measure: animal eye socket vein is got blood, measures MDA, SOD, GSH-PX, MAO-B:
MAD adopts the thiobarbituricacid method; SOD adopts xanthine oxidase.
5. result: the antioxidation of the compositions of Chinese medicine extract is as shown in table 2:
The result shows that the compositions of Chinese medicine extract can effectively be removed oxygen-derived free radicals.
Chinese prescription is to promoting the newborn effect of skin:
1. material: the 3T3 fibroblast, available from Shanghai RESEARCH ON CELL-BIOLOGY institute of the Chinese Academy of Sciences.
2. main agents:
MTT(Sigma company)
Trypsin DIFCO company)
PRMI-1640 culture fluid (GIBCO company)
3. passage is cultivated: the cell trypsinization contains the suspension of 10% calf serum PRMI-1640 culture fluid and is inoculated in 96 well culture plates, culture environment 5% carbon dioxide, 95% humidity.Inverted microscope is observed adherent situation and cellular morphology.
4. cell proliferation test: 96 well culture plate cells are grown behind the nearly monolayer, are changed to the culture fluid that contains the Chinese medicine extraction compositions, and the matched group culture fluid was cultivated after 48 hours, measured the cell proliferation situation with mtt assay.
5. result: the compositions of Chinese medicine extract is as shown in table 3 to the fibroblastic influence of 3T3:
The result shows that the compositions of Chinese medicine extract can promote fibroblast new life.
Claims (5)
1. Chinese medicine extract preparation of compositions method with anti aging effect effect, it is characterized in that: get respectively 10 kilograms of ginkgo nut, Semen Vitis viniferae, Semen sojae atricolor, the Fructus Sophorae, seed of Fructus Hippophae, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Juglandis, Radix Et Rhizoma Fagopyri Tataricis, ethanol with 50% soaked 24 hours for 1200 kilograms, the ethanol of residue reuse 50% soaked 24 hours for 1200 kilograms, to soak the gained extracting solution then merges, filter the back through 200 mesh filter screens and concentrate 20 times, with D101 macroporous resin on the concentrated solution, reuse 40% ethanol eluting is collected eluent namely.
2. Chinese medicine extract preparation of compositions method with anti aging effect effect, it is characterized in that: get respectively 10 kilograms of ginkgo nut, Semen Vitis viniferae, Semen sojae atricolor, the Fructus Sophorae, seed of Fructus Hippophae, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Juglandis, Radix Et Rhizoma Fagopyri Tataricis, ethanol with 80% soaked 20 hours for 1500 kilograms, the ethanol of residue reuse 80% soaked 20 hours for 1500 kilograms, to soak the gained extracting solution then merges, filter the back through 200 mesh filter screens and concentrate 30 times, with D101 macroporous resin on the concentrated solution, reuse 70% ethanol is eluting repeatedly, collects eluent namely.
3. Chinese medicine extract preparation of compositions method with anti aging effect effect, it is characterized in that: get 6 kilograms of ginkgo nuts, 6 kilograms of Semen Vitis viniferae, 7 kilograms of Semen sojae atricolor, 7 kilograms of the Fructuss Sophorae, 7 kilograms of seed of Fructus Hippophae, 9.5 kilograms of Fructus Lyciis, 16 kilograms of Fructus Schisandrae Chinensis, 13.5 kilograms of Semen Juglandis, 18 kilograms of Radix Et Rhizoma Fagopyri Tataricis, ethanol with 60% soaked 24 hours for 1000 kilograms, the ethanol of residue reuse 60% soaked 24 hours for 1000 kilograms, to soak the gained extracting solution then merges, filter the back through 200 mesh filter screens and concentrate 30 times, with D101 macroporous resin on the concentrated solution, reuse 80% ethanol is eluting repeatedly, collects eluent namely.
4. the purposes of a compositions that makes according to the described method of one of claim 1 to 3, for the preparation of skin care cosmetics or medicine, described cosmetics or medicine are cream, emulsion, astringent or facial film.
5. the purposes of compositions according to claim 4, it is characterized in that: with the compositions that makes through being evaporated to 1/2～1/5 of former weight, obtain composition concentrated solution, for the preparation of skin care cosmetics or medicine, wherein, described composition concentrated solution accounts for 5～10% of cosmetics or medicine gross weight.
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| CN108403506A (en) * | 2018-04-25 | 2018-08-17 | 姜凤艳 | Crease-resistant reparation eye cream of one kind and preparation method thereof |
| CN111568831B (en) * | 2020-06-19 | 2023-02-03 | 上海相宜本草化妆品股份有限公司 | Composition of Chinese herbal medicine extract for skin cosmetics and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1679794A (en) * | 2005-01-04 | 2005-10-12 | 华南理工大学 | Chinese medicine composition with tyrosinase activity inhibition and use thereof |
| CN101433666A (en) * | 2007-11-15 | 2009-05-20 | 上海家化联合股份有限公司 | Anti-aging Chinese herbal medicinal composition, preparation method and use thereof |
| CN101810556A (en) * | 2010-04-13 | 2010-08-25 | 上海相宜本草化妆品有限公司 | Combination of traditional Chinese medicine extractive with function of anti-skin aging, preparation and use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679794A (en) * | 2005-01-04 | 2005-10-12 | 华南理工大学 | Chinese medicine composition with tyrosinase activity inhibition and use thereof |
| CN101433666A (en) * | 2007-11-15 | 2009-05-20 | 上海家化联合股份有限公司 | Anti-aging Chinese herbal medicinal composition, preparation method and use thereof |
| CN101810556A (en) * | 2010-04-13 | 2010-08-25 | 上海相宜本草化妆品有限公司 | Combination of traditional Chinese medicine extractive with function of anti-skin aging, preparation and use |
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