CN1895503A - Hairy antler capsules - Google Patents
Hairy antler capsules Download PDFInfo
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- CN1895503A CN1895503A CNA2006100449410A CN200610044941A CN1895503A CN 1895503 A CN1895503 A CN 1895503A CN A2006100449410 A CNA2006100449410 A CN A2006100449410A CN 200610044941 A CN200610044941 A CN 200610044941A CN 1895503 A CN1895503 A CN 1895503A
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- cornu cervi
- cervi pantotrichum
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- hairy antler
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Abstract
A Chinese medicine 'Pilose antler capsule' for nourishing kidney and invigorating Yang is prepared from pilose antler, yam, dogwood fruit and tangerine peel proportionally through pulverizing pilose antler, decocting others three times, collecting decoction, concentrating, spray drying, pulverizing, mixing with said pilose antler powder, and loading in capsules.
Description
Technical field
The present invention relates to field of food, more specifically a kind of health care tonic-hairy antler capsules of warming and recuperating the kidney-YANG.
Technical background
Further perfect along with the develop rapidly of farming industry and foster deer technology, stag breeding also is rapidly developed, and it is increasing to support the deer amount, and the quality of Cornu Cervi Pantotrichum, output all significantly improve.In the Cornu Cervi Pantotrichum section, in the processing procedures such as drying, the dry crushing Cornu Cervi Pantotrichum is also more and more.Though its functional component does not reduce, compare price with the positive piece of antler of rule and differ many.For many years, the appreciation utilization of dry crushing Cornu Cervi Pantotrichum is inquired into by the relevant technologies expert always.
Cornu Cervi Pantotrichum is the main medicine of tonifying YANG, and with the medicine of Cornu Cervi Pantotrichum exploitation, medicated diet, health food are of a great variety, but many many prescriptions of seeing Cornu Cervi Pantotrichums.Research worker mostly is greatly asks quick-acting, and the using dosage of its Cornu Cervi Pantotrichum is all bigger.
Though edible back Yang-strengthening effect is obvious, locate to occur the red and swollen pimple of acne sample for some people at body surface such as hands, arm, abdomen, face, breast etc., even these red and swollen pimples also can appear at body interior.Brought certain side effect so take the more amount Cornu Cervi Pantotrichum to kidney invigorating and YANG supporting.Temperature compensation is not and dry, and mending and not blocking up is one of key issue of the strong positive medicine utilization of Cornu Cervi Pantotrichum class.
Summary of the invention
The objective of the invention is at the not enough of present dry crushing Cornu Cervi Pantotrichum development and use existence with owing to the bigger side effect that brings of Cornu Cervi Pantotrichum medicine taking dose, and, mend and stifled hairy antler capsules for the appreciation utilization of dry crushing Cornu Cervi Pantotrichum provides a kind of temperature compensation not dry.
Purpose of the present invention can realize by following technical measures:
It adopts following weight parts proportion raw material and method to make: a. is broken to the 80-200 order with the dry crushing Pulveratum Cornu Cervi Pantotrichum of 1-1.5, gets Pulveratum Cornu Cervi Pantotrichum; B. the Rhizoma Dioscoreae of 15-25, the Fructus Corni of 9-15, the Pericarpium Citri Reticulatae water decocting method of 3-5 are decocted three times, filter respectively, merging filtrate is condensed into cream, spray drying, and granule is crushed to the 80-200 order, must extract xeraphium; C. the extraction xeraphium with the Pulveratum Cornu Cervi Pantotrichum of a operation and b operation merges, evenly, rear packing
Purpose of the present invention also can realize by following technical measures:
Described spray-dired inlet temperature is 180-220 ℃, and outlet temperature is 60-100 ℃.
Rhizoma Dioscoreae, Fructus Corni and Pericarpium Citri Reticulatae decocting boil the employing conventional method, after water cleans, adding water is advisable just to flood, soaked 2-4 hour, and boiled then and keep boiling 0.5-1.5h, decoction liquor is squeezed filter with the 60-100 order respectively, carry out spray drying when again filtrate being concentrated into 0.8-1.2 times of this three flavors crude drug weight, the dry powder of must spraying, behind two kinds of powder mixings, each capsule loading amount is 0.35g.
In this prescription: Cornu Cervi Pantotrichum: the young horn of unossified close living fine hair on the stag head of animal in deer family Cervus nippon Temminck Cervus Nippon Temmi nck or Cervus elaphus linnaeus Cervus elaphusLinnaeus.
Rhizoma Dioscoreae: be herbaceous plant Rhizoma Dioscoreae Dioscorea opposita Thunb rhizome.
Fructus Corni: be the mature sarcocarp of Cornaceae defoliation small arbor plant Fructus Corni Cornus officinalis Sieb.et Zucc..
Pericarpium Citri Reticulatae: be the mature peel of the evergreen dungarunga plant of Rutaceae Fructus Citri tangerinae Citrus reticulate Blanco and variety thereof.
Cornu Cervi Pantotrichum flavor, sweet, salty, warm in nature, kind benefit man waist is suffered from a deficiency of the kidney cold, and the foot knee joint is unable, and spermatorrhea is from going out; Woman's metrorrhagia is leaked blood, and leucorrhea with red and white discharge has spermatogenesis and mends marrow, the tonifying YIN that nourishes blood, and the effect of strengthening the tendons and bones is we's monarch.Fructus Corni sweet in the mouth, acid, warm in nature, both the moon of invigorating the liver and kidney again can warming and recuperating the kidney-YANG, has that benefit is smart, settling five organs, the merit of logical nine orifices; Rhizoma Dioscoreae sweet in the mouth, property are flat, and kind tonification spleen the moon has " merit of nine clothes normal hearing and eyesight, " Rhizoma Dioscoreae invigorating middle warmer poly-, not dry, temperature compensation and can pass through eliminating stagnation, the acne vulgaris of healing; Add Pericarpium Citri Reticulatae and mend, open the sensible effect of gas with also mending.Four combinations, based on benefit, invigorating middle warmer has logical, makes to mend and stifled, to reach the merit of equilibrium between yin and yang.
The pharmacological action general introduction:
Cornu Cervi Pantotrichum contains multiple compositions such as aminoacid, cholesterol and esters, phospholipid, bird amine and active polypeptide, has antiinflammatory, anti-ageing, antitumor, antiulcer action, to cardiovascular, nervus centralis, gonad etc. is had extensive effect.Cornu Cervi Pantotrichum is the tonifying YANG key medicine.With 10% Pantocrine injection 1,2,4ml/kg sc.14d can promote to go prostate and the seminal vesicle growth of testis rat continuously, and its effect strengthens with dosage.Pantocrine, 5,10,15ml/kg ig.Continuously 21d can obviously increase teenage male mice testis, prostate Seminal vesicle weight and body weight, and make that testosterone content obviously increases in the mice serum.The male rat hypophysis cerebri of pantocrine 10mg/ml to cultivating, the lutropin secretion is increased, but add indometacin simultaneously, then the lutropin value significantly reduces than the former, possible its excretory excitation to lutropin is controlled through prostaglandin.
Rhizoma Dioscoreae is starch-containing, phlegmatic temperament, choline, allantoin and 16 seed amino acids, polyphenol oxidase and VC.Contain mannan and phytic acid etc. in the mucus.Can through water carry it.Rhizoma Dioscoreae cures mainly insufficiency of the spleen lack of appetite, incessant chronic diarrhea, and the deficiency of the lung is breathed with cough, chronic enteritis, diabetes, seminal emission, the enuresis, leucorrhea.
" not Lu " " end lumbago, control asthenia win thin, heat clearing away and restlessness relieving, reinforcing YIN-essence "." property of medicine opinion " " ends stomachache, relieving palpitation god "." Japan hanako materia medica ": " help the five internal organs, bone and muscle strengthening, long will calm the nerves cure mainly let out smart forgetful." " typhoid fever accumulate want ": " tonifying for the deficiency, clearind deficient heat ".Jia Suoxue " medicine justice " " temperature compensation and poly-, little perfume (or spice) and not dry "." book on Chinese herbal medicine is looked for the truth " embroidered in yellow palace, and Rhizoma Dioscoreae invigorating the spleen and replenishing QI heat extraction is though right gas is warm and flat." Chen Xiuyuan " book on Chinese herbal medicine is through reading " " Rhizoma Dioscoreae can kidney tonifying, essence replenishing.
Fructus Corni contains more glycoside, iridoid glycoside, and morroniside, sweroside, loganin and gallic acid Saponin etc. still contain ursolic acid, tartaric acid, malic acid, aminoacid, inorganic salt etc.These compositions are all water-soluble, so carry to good with water.
The Fructus Corni kidney-supplementing liver-boosting, essence astringing and desertion stemming cures mainly sexual impotence, seminal emission, the enuresis, the collapse of frequent micturition profuse sweating, interior-heat is thirsty clearly." property of medicine opinion ": " it is painful to control the brain bone, the kidney invigorating gas, Xing Yangdao.Add marrow." " Japan hanako materia medica ": " warm waist knee joint "." national Chinese herbal medicine compilation ": " liver and kidney tonifying arresting seminal emission hidroschesis cures mainly soreness of the waist and knees, sexual impotence, seminal emission, frequent micturition." Lee stile " Elementary Medicine ": can " this astringent of Fructus Corni also how lead to and send out heresy? cover all diseases and all lie in the bottom deficiency and coldness, that uses takes a tonic or nourishing food to build up one's health Liver and kidney, with Yi Qiyuan, and the five internal organs Amway then, the logical and sharp person of the person of closing ends." the light circulation of Fei Ruota medicine meaning also.Miao Xiyong " Bencao Jingshu " " Fructus Corni is controlled pathogen cold and heat under the heart, the intestines and stomach ailment said due to cold or exposure, cold and heat wind syndrome of head, wind degas and, nasal obstruction, the acne vulgaris person, all Liver and kidney the two lead, two through the deficiency-heat card that sees before of dying.This medicine temperature can be passed through, and suffering can be wandered away, and acid can be gone into liver, and holds back deficiency-heat, and ailment said due to cold or exposure is diffusing clearly, and then the intestines and stomach cold and heat are from removing under the heart, and the head is also clear sharp, and the nasal obstruction acne vulgaris is known more also.By cold warm addiction numbness person, borrow its hot temperature eliminating stagnation, row and mending.Temperature and main the benefit, sour in the mouth and main holding back are so vital essence benefit and the moon are by force also.Lean then the five internal organs is stolen diarrhea from pacifying nine.”
Pericarpium Citri Reticulatae: contain volatile oil, flavonoid glycoside (as hesperidin), nobiletin and V
B, V
CDeng.Mostly be water decoction, carry to good with water.Its hesperidin has the effect of Citrin sample, can fall capillary permeability, anti-microvascular bleeding; The vascular permeability that energy antagonism histamine and hemolytic phospholipid cause increases, the proteic dissolving of energy fortifying fibre, and antithrombotic forms, and choleretic effect is arranged.
Pericarpium Citri Reticulatae hardship, suffering, temperature, go into lung, liver, spleen, stomach four warps.Hardship can be let out can be dry, hot can loosing, the temperature energy with, often get the dry using warming therapy merit of regulating the flow of vital energy.Then mend with tonic.Then rush down with cathartic, then rise, then fall with falling medicine with Hydrargyri Oxydum Rubrum.Ni Zhumo " book on Chinese herbal medicine converge with speech ": " Pericarpium Citri tangerinae is total to belong to the treasure who regulates the flow of vital energy, if cholera vomiting gas contrary also; Trembling with fear also of the diarrhea accompanied with flatus of having loose bowels; The obstruction and rejection fullness in the epigastrium and abdomen, the closing also of gas; The food stagnation sputum, the stagnating also of gas; Wind and cold administration is wet, gas rich also; Seven emotions strongly fragrant, the knot of gas is also; The Pericarpium Citri tangerinae system can be controlled it.The lid acrid in the mouth is kind to loose, so can open gas, bitter in the mouth is apt to let out, so can manage it expectorant; Its temperature is flat, is good at leading to.”
Cornu Cervi Pantotrichum is the kidney invigorating and YANG supporting key medicine, and the composition complexity is extracted and often to be lost many active ingredients, and is complete in for well.The major function composition of Fructus Corni, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, all water-soluble, be good with water boiling and extraction.Cornu Cervi Pantotrichum is monarch with the kidney-replenishing.Rhizoma Dioscoreae and Fructus Corni are we's ministerial drug.Pericarpium Citri Reticulatae bitter in the mouth, virtue, warm in nature have the merit of circulation of qi promoting spleen invigorating, help this medicine in the nourishing less, mend and oiliness adjuvant drug for it to help spleen fortune, to make.Take a broad view of full side, kidney-replenishing, benefiting essence-blood, bone and muscle strengthening is congenital to reach benefit, supports the day after tomorrow, the effect of equilibrium between yin and yang.
The zoopery of Yang-strengthening effect:
Take out to give birth to healthy male rat about 20 days body weight 50g, the shallow fiber crops of ether are excision two side testis down, divide positive at random and negative control group and experimental group.Dosage and method administration in according to the form below next day of operation back.Every day 1 continuous 14d, 24h puts to death animal after postoperative administration next day, extracting extract capsule and prostate are gone into Bouins liquid, the taking-up of spending the night, degrease.Cut off deferent duct, urethra and bladder at nearly body of gland place.Claim weight in wet base.Put body of gland again and spend the night, take out and to peel urethra off in 70% alcoholic solution, can claim seminal fluid capsule and prostate weight in wet base.
After winning body of prostate, near penis two bottom sides pubic symphysis is isolated the oval preputial glands of redness rapidly, wins to claim its weight in wet base.Its experiment the results are shown in following table.
Hairy antler capsules is to the influence (n=10) of reduce phlegm and internal heat rat prostate and seminal fluid capsule, preputial glands ponderal index
| Group | Medicine and dosage | Prostate and seminal fluid capsule weight in wet base index | Preputial glands weight in wet base index |
| ?mg/kg | (the mg/100g body weight, x ± SD) | Mg/100g body weight x ± SD | |
| Control group, water positive drug group hairy antler capsules powder group hairy antler capsules powder group hairy antler capsules powder group | 2ml/kg (filling stomach) testosterone propionate 25 (intramuscular injection) 70mg (irritating stomach after adding water) 140mg (irritating stomach after adding water) 280mg (irritating stomach after adding water) | 41.3±13.2 90.5±13.2*** 47.3±9.2* 49.5±8.9** 51.7±10.0** ? ? ? | 23.2±9.0 97.3±21.3*** 27.7±10.0* 29.9±15.2* 34.0±14.5** ? ? ? |
Learn from experiment: this hairy antler capsules can promote castrated rats prostate and seminal fluid capsule significantly, the growth promoter of preputial glands and strengthen with the increase of dosage.
The curative effect clinical observation:
1) case is selected:
The case of making is married outpatient service erection problem prescription on individual diagnosis patient:
36-45 year 2 people; 46-55 year 10 people; 56-65 year 17 people; 66-67 year 3 people.
2) method of administration:
Capsule of the present invention, every day 3 times, each 3,1 week was a course of treatment.
3) diagnostic criteria: with erection, libido with whether have sexual intercourse successfully be diagnostic criteria:
1. libido completely loses or dislikes, and no sexual life requires or detests sexual life, does not have and erects, and it is not hard to erect, and it is unsuccessful to have sexual intercourse.
2. libido poor slightly (libido more of the same age requires low) erection is still hard, has sexual intercourse and exempts from strong success.
3. libido normal (reaching) with age normal sexual desire requirement
Finished erection in 2 minutes, it is hard to erect, and having sexual intercourse can success.
4. side effect diagnosis, face and health have or not acne sample pox, and whether urethra has scorching hot pain.
4) criterion of therapeutical effect
Produce effects: libido is normal, and it is hard to erect, and has sexual intercourse successfully
Effectively: libido is arranged, and it is hard and strong to erect, but bad during fashion, the success reluctantly of having sexual intercourse.
Invalid: erecing makes progress, but it is unsuccessful to have sexual intercourse, and treats no significant change.
5) hairy antler capsules 32 routine clinical efficacy results
| Age group | 36-45 year | 46-55 year | 56-65 year | 66-67 year |
| Patient's number | 2 people | 10 people | 17 people | 3 people |
| The produce effects enabledisable | 2 0 0 | 10 0 0 | 15 2 0 | 2 1 0 |
In 32 routine patients, produce effects person 29 people; Responder 3 people; Nonresponder 0 people.
Suffer from the example at all, do not find that all facial and health has acne sample pox or skin ulcer, urethra does not have scorching hot pain, noninductive uncomfortable person.The kidney invigorating and YANG supporting of said preparation, the effect of temperature compensation mediation have been shown.
The present invention has opened up a new way for the appreciation utilization of dry crushing Cornu Cervi Pantotrichum, and processing technology thereof is simple, cost is low, do not destroy any active component, and provide an appropriate Cornu Cervi Pantotrichum taking dose, avoided because the bigger side effect that brings of Cornu Cervi Pantotrichum medicine taking dose, realized temperature compensation and not dry, mended and stifled purpose.
Model case:
Example 1: open * *, the man, 66 years old, the retired cadre suffered from impotence disease 3 years, once took medicines such as " NANBAO ", some curative effect.Though patient's erection disturbance, libido is normal.Take hairy antler capsules of the present invention after one week, it is fast to show as startup, and hard, longer duration is had sexual intercourse successfully, has not felt uncomfortable, and the state of an illness is clearly better, and now continues to take.
Example 2: chaste tree * *, the man, 37 years old, certain small towns worker, readme is sexual disorder over 2 years, and the state of an illness increases the weight of since last year, and can not have sexual intercourse, and once takes " kidney tonic liquid ", and " JINGUI SHENQI WAN " etc., effect do not show, and take hairy antler capsules of the present invention.Readme libido and erection function recover normally to have sexual intercourse successfully fully, and be not uncomfortable, the sense of no urethra causalgia, and health does not have peculiar symptom and occurs.
The specific embodiment
Embodiment 1
Get dry crushing Cornu Cervi Pantotrichum 1kg, be crushed to 80 orders, get Pulveratum Cornu Cervi Pantotrichum;
Get Rhizoma Dioscoreae 25kg, Fructus Corni 9kg, Pericarpium Citri Reticulatae 5kg, after adding water and cleaning, add water to again flood till, soak 2h, decoct then three times, each constantly boiling 1.5 hours and 60 orders squeeze filter, merge three times filtrate, when being concentrated into 1.2 times of this three flavors crude drug weight, carry out spray drying, inlet temperature is 220 ℃, 60 ℃ of outlet temperatures, broken and mistake 80 mesh sieves must extract xeraphium with spray-dired medicated powder;
At last Pulveratum Cornu Cervi Pantotrichum and extraction xeraphium are combined and mixing dress capsule, each capsule dress 0.35g.
Embodiment 2
Get dry crushing Cornu Cervi Pantotrichum 1.5kg, micronizing to 200 order gets Pulveratum Cornu Cervi Pantotrichum;
Get Rhizoma Dioscoreae 15kg, Fructus Corni 15kg, Pericarpium Citri Reticulatae 3kg, after adding water and cleaning, add water to again flood till, soak 4h, decoct then three times, each constantly boiling 0.5 hour and 100 orders squeeze filter, merge three times filtrate, when being concentrated into 0.8 times of this three flavors crude drug weight, carry out spray drying, inlet temperature is 180 ℃, 100 ℃ of outlet temperatures, broken and mistake 200 mesh sieves must extract xeraphium with spray-dired medicated powder;
At last Pulveratum Cornu Cervi Pantotrichum and extraction xeraphium are combined and mixing dress capsule, each capsule dress 0.35g.
Embodiment 3
Get dry crushing Cornu Cervi Pantotrichum 1.2kg, micronizing to 150 order gets Pulveratum Cornu Cervi Pantotrichum;
Get Rhizoma Dioscoreae 20kg, Fructus Corni 12kg, Pericarpium Citri Reticulatae 4kg, after adding water and cleaning, add water to again flood till, soak 3h, decoct then three times, each constantly boiling 1 hour and 80 orders squeeze filter, merge three times filtrate, when being concentrated into 1 times of this three flavors crude drug weight, carry out spray drying, inlet temperature is 200 ℃, 80 ℃ of outlet temperatures, broken and mistake 150 mesh sieves must extract xeraphium with spray-dired medicated powder;
At last Pulveratum Cornu Cervi Pantotrichum and extraction xeraphium are combined and mixing dress capsule, each capsule dress 0.35g.
Claims (2)
1, a kind of hairy antler capsules is characterized in that its adopts following weight parts proportion raw material and method to make:
A. the dry crushing Pulveratum Cornu Cervi Pantotrichum with 1-1.5 is broken to the 80-200 order, gets Pulveratum Cornu Cervi Pantotrichum;
B. the Rhizoma Dioscoreae of 15-25, the Fructus Corni of 9-15, the Pericarpium Citri Reticulatae water decocting method of 3-5 are decocted three times, filter respectively, merging filtrate is condensed into cream, spray drying, and granule is crushed to the 80-200 order, must extract xeraphium;
C. the extraction xeraphium with the Pulveratum Cornu Cervi Pantotrichum of a operation and b operation merges, evenly, rear packing.
2, according to claims 1 described a kind of hairy antler capsules, it is characterized in that described spray-dired inlet temperature is 180-220 ℃, outlet temperature is 60-100 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100449410A CN100374136C (en) | 2006-06-21 | 2006-06-21 | Hairy antler capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100449410A CN100374136C (en) | 2006-06-21 | 2006-06-21 | Hairy antler capsules |
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| Publication Number | Publication Date |
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| CN1895503A true CN1895503A (en) | 2007-01-17 |
| CN100374136C CN100374136C (en) | 2008-03-12 |
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ID=37608244
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100449410A Expired - Fee Related CN100374136C (en) | 2006-06-21 | 2006-06-21 | Hairy antler capsules |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904964A (en) * | 2010-07-28 | 2010-12-08 | 林勇 | Cartialgenous bone strengthening capsule |
| CN106334063A (en) * | 2016-09-21 | 2017-01-18 | 河南中医药大学 | Cornu cervi pantotrichum powder for treating perimenopausal syndrome |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058629C (en) * | 1997-09-09 | 2000-11-22 | 沈静波 | 'Longteng' medicinal wine |
-
2006
- 2006-06-21 CN CNB2006100449410A patent/CN100374136C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904964A (en) * | 2010-07-28 | 2010-12-08 | 林勇 | Cartialgenous bone strengthening capsule |
| CN106334063A (en) * | 2016-09-21 | 2017-01-18 | 河南中医药大学 | Cornu cervi pantotrichum powder for treating perimenopausal syndrome |
| CN106334063B (en) * | 2016-09-21 | 2019-06-18 | 河南中医药大学 | A kind of pilose antler powder for treating perimenopausal syndrome |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100374136C (en) | 2008-03-12 |
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