CN1048325A - The preparation method of skin ointment for healing ulcered wound - Google Patents

Abstract

The present invention is a kind of preparation method for the treatment of ulcerative colitis medicine oil preparation.It is Radix Scutellariae, Cortex Phellodendri or the Radix Sanguisorbae of shining dry grinding with cleaning, Rhizoma Coptidis, the Radix Pulsatillae or Fructus Rosae Laevigatae, Radix Angelicae Sinensis or Radix Vladimiriae, the Radix Glycyrrhizae Fructus Chebulae places hermetic container to soak 3-7 days with vegetable fatty oil, is heated to 150-250 ℃ then and decocts 10-30 minute, after elimination medicinal residues, filtrate temperature are reduced to room temperature, dried Alumen that adding is pulverized or Sanguis Draxonis, Gypsum Fibrosum Preparatum, Borneolum Syntheticum, stirring gets final product.The skin ointment for healing ulcered wound that this law makes has anti-inflammation, antidiarrheal hemostasis, promoting blood circulation to relieve pain, expelling pus and promoting granulation effect, and usual amounts 10-50ml, clean the anus medicine-feeding after an action of the bowels once every day, rectally.Works very well.

Description

The preparation method of skin ointment for healing ulcered wound

The present invention relates to a kind of preparation method for the treatment of the ulcerative colitis medicine, particularly a kind of preparation method for the treatment of ulcerative colitis external Chinese medicine oil preparation.

Ulcerative colitis is the able-bodied diseases of a kind of serious harm people, all adopts folk prescription antibiotics class and astringing to arrest diarrhea drug combination at present both at home and abroad, as bactrim, and the gentamycin sulfate and bismuth subcarbonate capsules capsule, but therapeutic effect is all not ideal enough.The method of the employing Chinese and western medicine enema that has is treated, and institute's medication Chinese herbs decoction often takes coloclysis, each used in amounts 300-500ml, treatment time half a year-1 year, the expense height, effect is undesirable, operation inconvenience, patient is painful.It is that the raw material for treating ulcerative colitis is effective with Chinese medicine that event is sought a kind of, uses and deposits real necessity that belongs to of medicaments preparation method easily.

It is the preparation method of the efficient medicine oil preparation of raw material treatment ulcerative colitis with Chinese medicine that task of the present invention provides a kind of, the method realizes that easily this medicament adopts rectally, medicine directly acts on the ulcer surface place, the curative effect height, dosing is few, each 30-50ml, short treating period (30-60 days), patient is not painful during use, is convenient to deposit.

The present invention is achieved in that clean drying in the sun Radix Scutellariae 20-60g, Cortex Phellodendri or Radix Sanguisorbae 20-60g, Radix Pulsatillae 20-60g or Fructus Rosae Laevigatae 20-50g, Radix Angelicae Sinensis or Radix Vladimiriae 25-50g, Radix Glycyrrhizae 15-50g, Fructus Chebulae 10-30g, Rhizoma Coptidis 10-30g pulverizes, and places airtight oil resistant container, as bottle, jar, in the cylinder, the adding fatty oil (as Oleum Arachidis hypogaeae semen, Oleum Glycines, cotton oil, vegetable oil, Oleum Sesami etc.) 1000ml stirs evenly airtight immersion 3-7 days, then with the medicine of container together with above-mentioned dipping, placing fire to go up heating endures, temperature 150-250 ℃, time 10-30 minute, refilter slagging-off, when reducing to room temperature, the filtrate temperature adds dried Alumen or the Sanguis Draxonis 5-10g that pulverizes, Gypsum Fibrosum Preparatum 5-15g, Borneolum Syntheticum 1-5g stirs, promptly make the medicine oil preparation (skin ointment for healing ulcered wound) of treatment ulcerative colitis, be sub-packed in containers for future use.

Used dried Alumen is that cooling was pulverized 200 sieves and got after placing a pot interior heat-flash to be fired to all to be white withered color with clean Alumen in this muscle-growing oil.

The used Fructus Chebulae of this skin ointment for healing ulcered wound chooses decontamination with natural Fructus Chebulae, smash, place pot fire to go up the intense fire heating, putting into Testa Tritici skin (every 500g Fructus Chebulae with 125g Testa Tritici skin) in the pot fries when the Testa Tritici skin plays cigarette, the Fructus Chebulae that input is smashed, slowly stir-fry be buff to Fructus Chebulae's appearance after, take out sieve and remove the Testa Tritici skin, the Fructus Chebulae pulverized get final product.

The preparation of used Gypsum Fibrosum Preparatum in this skin ointment for healing ulcered wound is Gypsum Fibrosum to be placed to be fired on the fire be popular in, and after the taking-up cooling, pulverizes 200 sieves and gets final product.

Above-mentioned used Sanguis Draxonis, Borneolum Syntheticum all will pulverize the 120-200 sieve.

Distillation and extraction method is preferably adopted in the processing of its Radix Angelicae Sinensis.Radix Angelicae Sinensis medicated powder is put into distillator, add water to container 1/2-2/3 place, connect condensing unit, add thermal distillation, collect distillate, add an amount of Sal in the distillate and saltout, make volatile oil and water stratification, it is standby to collect volatile oil.

Skin ointment for healing ulcered wound with method of the present invention makes has anti-inflammation, the antidiarrheal hemostasis, and promoting blood circulation to relieve pain, the expelling pus and promoting granulation effect, usual amounts 10-50ml cleans anus medicine-feeding 1 time every day after an action of the bowels, rectally, medicine directly acts on ulcer surface, and is effective.

Its pharmacology is a Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis is anti-inflammation preferably, Radix Angelicae Sinensis energy promoting blood circulation to relieve pain, can improve partial blood circulation, Gypsum Fibrosum Preparatum, Fructus Chebulae, Sanguis Draxonis, dried Alumen all has stopping leak hemostasis astriction, can quicken the healing of ulcer surface, Borneolum Syntheticum can relieve the pain, and Radix Glycyrrhizae has anti-allergic effects, this agent adopts fatty oil to make solvent in addition, intestinal there is lubrication, reduces the friction of stool, can delay the drainage of medicine simultaneously ulcer surface, make medicine give full play to usefulness, quicken the healing of ulcer surface, treatment uses this agent to adopt and rectally, belongs to and shooting the arrow at the target, medicine directly acts on ulcer surface, also is an in order to be effective main cause.

Skin ointment for healing ulcered wound with method preparation of the present invention carries out clinical practice in the disabled soldier of Hubei Province convalescent home, successively treats chronic ulcerative colitis 40 multiple-cases, all obtains promising result.

Embodiment 1, gets the Radix Scutellariae 30g that handled by preceding method, Cortex Phellodendri 20g, Radix Pulsatillae 30g, Rhizoma Coptidis 10g, Radix Angelicae Sinensis 50g, Radix Glycyrrhizae 15g, Fructus Chebulae 20g places in the jar, adds 1000ml Oleum Sesami and soaks 7 days, then jar is heated together with soak medicine, make it to be heated to 150 ℃ and fried in shallow oil filter and remove residue 30 minutes, when treating that temperature is reduced to room temperature, add Gypsum Fibrosum Preparatum 5g, dried Alumen 5g, Borneolum Syntheticum 5g, the containers for future use of packing into and sterilizing after stirring evenly.

The Wang, the man, 60 years old, suffered from the discontinuity bloody purulent stool 2 years, defecate 10-20 every day, the anus tenesmus, companion's low grade fever, body is become thin, in certain institute of traditional Chinese medicine's microscopic examination of rectum sigmoid colon mucosa hyperemia, edema, the ulcer surface that has being dispersed in property to differ in size, the chemical examination erythrocyte +++, pyocyte +++.Be diagnosed as chronic ulcer colitis, adopt the Chinese herbs decoction coloclysis, intravenously administrable treatment was not felt any better in 1 year, changed 1 10 days course of treatment of my pharmaceutical treatment of institute through making with the inventive method over to, and symptom is clearly better, laboratory examination erythrocyte (+), pyocyte (+) continues three courses of treatment of medication, symptom complete obiteration, the microscopic examination of rectum ulcer surface all heals, and follows up a case by regular visits to not recurrence in 1 year after leaving hospital in 40 days.

Embodiment 2, get the Radix Scutellariae 20g that handled by preceding method, Radix Sanguisorbae 60g, Radix Pulsatillae 20g, Radix Vladimiriae 25g, Radix Glycyrrhizae 20g, Rhizoma Coptidis 30g, Fructus Chebulae 10g adds 1000ml Oleum Glycines and soaked 3 days, heat to 250 ℃, decoct 10 minutes, cross the elimination medicinal residues, when treating that the filtrate temperature is reduced to 20 ℃, add Sanguis Draxonis 7g, Borneolum Syntheticum 1g, Gypsum Fibrosum Preparatum 5g stirs evenly the containers for future use of packing into after sterilizing.

Zhan, woman, 25 years old, suffer from the painful diarrhea of discontinuity abdomen, Mucous Stool 6 years, defecate 4-5 every day, the per rectum microscopy is diagnosed as chronic ulcerative colitis, 3-5 of stool laboratory examination erythrocyte, pyocyte 0-3, it is invalid to add western medicine enema with Chinese herbs decoction, go into my institute after the skin ointment for healing ulcered wound that makes with the inventive method 7 days, stool is normal, continues to strengthen recovery from illness in 20 days, follows up a case by regular visits to not recurrence in 1 year after leaving hospital.

Embodiment 3, get the Rhizoma Coptidis 20g that handled by preceding method, Radix Pulsatillae 60g, Cortex Phellodendri 60g, Radix Scutellariae 60g, Radix Angelicae Sinensis 35g, Radix Glycyrrhizae 30g, Fructus Chebulae 10g adds cotton oil 1000ml, soaked 5 days, and be heated to 200 ℃ and decoct 20 minutes, the elimination medicinal residues, filtrate treats to add when temperature is reduced to room temperature Borneolum Syntheticum 3g, Gypsum Fibrosum Preparatum 15g, Sanguis Draxonis 5g, standby after stirring evenly.

Poplar, the man 38 years old, suffered from the painful diarrhoea of abdomen 3 years, in local county hospital diagnosing chronic colitis, it is invalid to have an injection through taking medicine, and does the inspection of fiber colon to certain hospital and is diagnosed as chronic ulcerative colitis, goes into the court and checks stool routine examination pyocyte (+++), microscopic examination of rectum is determined sigmoid colon, the ulcer surface that whole position has being dispersed in property to differ in size, the said medicine treatment recovery from illness in 30 days through making with the present invention is left hospital, and follows up a case by regular visits to and does not see recurrence in 1 year.

Embodiment 4, get the Cortex Phellodendri 20g that handled by preceding method, Radix Scutellariae 30g, Fructus Rosae Laevigatae 50g, Fructus Chebulae 30g, Radix Vladimiriae 50g, Rhizoma Coptidis 30g, Radix Glycyrrhizae 30g adds Oleum Arachidis hypogaeae semen 1000ml, soak after 4 days, be heated to 160 ℃ and decoct 30 minutes, the elimination medicinal residues, treat to add when the filtrate temperature is reduced to 20 ℃ dried Alumen 10g, Borneolum Syntheticum 4g, Gypsum Fibrosum Preparatum 5g, standby after stirring evenly.

Lee, the man, 30 years old, the outbreak repeatedly of suffering from diarrhoea over 5 years was defecated 4-10 time every day, microscopic examination of rectum finds to have apart from the about 8cm of anus place the ulcer surface of 3 about 2cm of diameter, once used the Chinese and Western oral medicine, multiple treatment such as coloclysis is not felt any better, 3 courses of treatment of skin ointment for healing ulcered wound treatment through making with the inventive method, recovery from illness is left hospital, and follows up a case by regular visits to not recurrence in 1 year.

Claims (4)

1, a kind of preparation method for the treatment of ulcerative colitis medicine oil preparation, it is characterized in that to clean the Radix Scutellariae 20-60g that shines dry grinding, Cortex Phellodendri or Radix Sanguisorbae 20-60g, Radix Pulsatillae 20-60g or Fructus Rosae Laevigatae 20-50g, Radix Angelicae Sinensis or Radix Vladimiriae 25-50g, Radix Glycyrrhizae 15-50g, Rhizoma Coptidis 10-30g, Fructus Chebulae 10-30g place pottery class hermetic container, with vegetable fatty oil (Oleum Arachidis hypogaeae semen or Oleum Glycines, cotton oil, vegetable oil, Oleum Sesami etc.) 1000ml soaked 3-7 days, then container is heated to 150-250 ℃ together with the medicine that soaks and fried in shallow oil 10-30 minute, the elimination medicinal residues are after the filtrate temperature is reduced to room temperature, add the dried Alumen or the Sanguis Draxonis 5-10g that pulverize, Gypsum Fibrosum Preparatum 5-15g, Borneolum Syntheticum 1-5g stirs promptly.

2, the preparation method of medicine oil preparation according to claim 1, it is characterized in that described dried Alumen be with clean Alumen place a pot interior heat-flash be fired to white withered after, cooling, pulverize, cross 200 mesh sieves and thing.

3, the preparation method of medicine oil preparation according to claim 1, it is characterized in that used Fructus Chebulae chooses decontamination with natural Fructus Chebulae, smash, in pot, heat slowly to stir-fry to appearance and be buff with the Testa Tritici skin that make popular to such an extent that plays cigarette, take out cold slightly, sieve removes the Testa Tritici skin, the Fructus Chebulae is pulverized get final product, and Fructus Chebulae and Testa Tritici skin weight ratio are 4: 1.

4, the preparation method of medicine oil preparation according to claim 1 is characterized in that used Gypsum Fibrosum Preparatum is Gypsum Fibrosum to be placed forge on the fire to being popular in postcooling, pulverizing, cross 200 mesh sieves and thing.