CN111588783A - Traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation and preparation method thereof - Google Patents
Traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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Abstract
The invention discloses a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation, which comprises, by weight, 20-40 parts of sophora flavescens, 15-35 parts of fructus kochiae, 2-4 parts of saffron crocus, 15-35 parts of golden cypress, 15-35 parts of fructus cnidii, 20-40 parts of herba patriniae, 10-30 parts of dandelion, 50-150 parts of small molecule active peptide, 50-150 parts of glycerol, 50-150 parts of white oil, 50-150 parts of glycerol stearate and 0.5-1.5 parts of propylparaben. A preparation method of a Chinese medicinal antibacterial ointment for treating gynecological inflammation comprises weighing the above Chinese medicinal components (radix Sophorae Flavescentis, Kochiae fructus, stigma croci Sativi, cortex Phellodendri, fructus Cnidii, herba Patriniae, and herba Taraxaci) at a certain weight ratio, wrapping with gauze, tightening, placing into a decocting vessel, adding 4-6 times of water, boiling with strong fire, decocting for 10-20 min, and decocting with slow fire for 30-40 min to obtain medicinal liquid. The method mainly controls the growth and the reproduction of bacteria and viruses in a bacteriostatic way, has no stimulation to the vaginal wall, and plays a role in repairing and conditioning.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation and a preparation method thereof.
Background
The common gynecological diseases include vaginitis, trichomonas vaginalis, vaginal erosion, vaginal pruritus, leukorrhagia, malodor, etc. Is a disease which seriously troubles women's normal work, study and labor, amusement and life. At present, many disinfecting preparations are used for solving the diseases in China, similar products in the market are mostly gels, the main components of the gel are chemical preparations, metronidazole, chlorhexidine diacetate and the like all belong to broad-spectrum antibiotics, and secondary infection caused by imbalance of environmental flora in the vagina is easily caused. The squamous epithelial cells of the vaginal wall are seriously stimulated, and the disease is repeatedly attacked. Because the morbidity of the female reproductive system is high, the traditional Chinese medicine gynecological bacteriostatic paste is specially developed in order to effectively and reasonably control diseases of special female regions.
Disclosure of Invention
The technical problem to be solved by the invention is to overcome the technical defects and provide a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation and a preparation method thereof
In order to achieve the purpose of the invention, the invention adopts the technical scheme that: a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation comprises the following components in parts by weight: 20-40 parts of radix sophorae flavescentis, 15-35 parts of fructus kochiae, 2-4 parts of saffron crocus, 15-35 parts of golden cypress, 15-35 parts of fructus cnidii, 20-40 parts of herba patriniae, 10-30 parts of dandelion, 50-150 parts of small molecule active peptide, 50-150 parts of glycerol (glycerin), 50-150 parts of white oil, 50-150 parts of glycerol stearate and 0.5-1.5 parts of nipagin propyl ester.
Further, 30 parts of radix sophorae flavescentis, 25 parts of fructus kochiae, 3 parts of saffron crocus, 25 parts of golden cypress, 25 parts of fructus cnidii, 30 parts of herba patriniae, 20 parts of dandelion, 100 parts of small molecule active peptide, 100 parts of glycerol (glycerin), 100 parts of white oil, 100 parts of glyceryl stearate and 1 part of nipagin propyl ester.
A preparation method of a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation comprises the following steps:
the method comprises the following steps: weighing the above traditional Chinese medicine components (radix Sophorae Flavescentis, Kochiae fructus, stigma croci Sativi, cortex Phellodendri, fructus Cnidii, herba Patriniae, and herba Taraxaci) according to weight ratio, wrapping with gauze, tightening, placing into a decocting device, adding 4-6 times of water, boiling with strong fire, decocting for 10-20 minutes, and decocting with slow fire for 30-40 minutes to obtain decoction;
step two: and (4) removing residues, filtering the medicinal liquid obtained in the step (1), and reserving the filtrate for later use.
Step three: sequentially adding the small molecule active peptide and the stearin into the filtrate obtained in the step two, stirring and heating to 80 ℃ until the small molecule active peptide and the stearin are completely dissolved to obtain a solution A;
step four: mixing glycerol (glycerin) and white oil together, heating to 60 ℃, and continuously stirring to melt to obtain a solution B;
step five: mixing the solution A and the solution B obtained in the third step and the fourth step together to obtain a solution C;
step six: adding propylparaben into the solution C obtained in the fifth step, stirring for 30 minutes, heating to 50 ℃, and emulsifying to obtain paste;
step seven: after the emulsified paste is cooled, 5 g of the emulsified paste is canned by a disposable dosing device, and the emulsified paste is packaged.
The invention has the beneficial effects that: the method mainly controls the growth and the reproduction of bacteria and viruses in a bacteriostatic way, has no stimulation to the vaginal wall, and plays a role in repairing and conditioning. Can be used for treating abnormal odor of leucorrhea, vaginitis, cervicitis, endometritis, adnexitis, and menoxenia due to ovarian dysfunction in female special region. The traditional Chinese medicine has the synergistic effect, the effect is doubled, the curative effect is good, the side effect is small, the safety is high, and the traditional Chinese medicine can be used for a long time.
Detailed Description
In order to make the content of the present invention more clearly understood, the technical solutions in the embodiments of the present invention are clearly and completely described below.
The preparation method comprises the following steps of (1) preparing broom cypress fruit: has the functions of clearing away heat and toxic material, dispelling wind and arresting itching. Has good effects on pruritus vulvae and eczema, and has the functions of clearing heat, promoting diuresis and resisting dermatophytes.
Flavescent sophora root: clearing heat and drying dampness, killing parasites, promoting urination, treating leucorrhea with reddish discharge, swelling and itching of yin, eczema, skin pruritus, mange tinea and leprosy, and externally treating trichomonas vaginitis.
Phellodendron bark: it is cold in nature and bitter in taste, has the functions of clearing heat and drying dampness, purging fire and removing toxicity, and is commonly used for damp-heat diarrhea, dysentery, jaundice and leucorrhea.
Fructus cnidii: has effects of warming kidney and tonifying yang.
Herba Patriniae: has effects of tranquilizing mind, clearing away heat and toxic materials, dispelling blood stasis, and expelling pus, and can be used for inhibiting Staphylococcus aureus.
Small molecule active peptides: promoting hormone secretion, promoting absorption, regulating immunity, regulating nerve transmission, promoting cell separation, enhancing cell metabolism rate, ensuring protein growth in human cells, ensuring normal growth and development of human body, and preventing aging and diseases.
Saffron: sweet taste and slightly cold nature, mainly enters heart and liver channels, has the effects of promoting blood circulation to remove blood stasis, relieving depression and tranquilization, cooling blood and removing toxicity, is used for amenorrhea and abdominal mass, postpartum stasis, melancholy or mania, protecting liver, regulating immunologic function, delaying aging, resisting tumors and the like.
The first embodiment is as follows: a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation comprises the following components in parts by weight: 20 parts of radix sophorae flavescentis, 15 parts of fructus kochiae, 2 parts of saffron crocus, 15 parts of golden cypress, 15 parts of fructus cnidii, 20 parts of herba patriniae, 10 parts of dandelion, 50 parts of small molecule active peptide, 50 parts of glycerol, 50 parts of white oil, 50 parts of glycerol stearate and 0.5 part of nipagin propyl ester.
Example two: a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation comprises the following components in parts by weight: 40 parts of radix sophorae flavescentis, 35 parts of fructus kochiae, 4 parts of saffron crocus, 35 parts of golden cypress, 35 parts of fructus cnidii, 40 parts of herba patriniae, 30 parts of dandelion, 150 parts of small molecule active peptide, 150 parts of glycerol, 150 parts of white oil, 150 parts of glycerol stearate and 1.5 parts of nipagin propyl ester.
Example three: 300g of radix sophorae flavescentis, 250g of fructus kochiae, 30g of saffron crocus, 250g of cortex phellodendri, 250g of fructus cnidii, 300g of herba patriniae, 200g of dandelion, 1000g of small molecule active peptide, 1000g of glycerol, 1000g of white oil, 1000g of glycerol stearate and 10g of nipagin propyl ester.
A preparation method of a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation comprises the following steps:
the method comprises the following steps: weighing the traditional Chinese medicine components (radix sophorae flavescentis, fructus kochiae, saffron crocus, golden cypress, fructus cnidii, herba patriniae and dandelion) according to the weight ratio, wrapping and tightening the traditional Chinese medicine components by using gauze, putting the traditional Chinese medicine components into a decocting device, adding 8Kg of water, boiling with strong fire, decocting for 10 minutes, and then decocting with slow fire for 30 minutes to obtain medicine juice;
step two: and (4) removing residues, filtering the medicinal liquid obtained in the step (1), and reserving the filtrate for later use.
Step three: sequentially adding the small molecule active peptide and the stearin into the filtrate obtained in the step two, stirring and heating to 80 ℃ until the small molecule active peptide and the stearin are completely dissolved to obtain a solution A;
step four: mixing glycerol (glycerin) and white oil together, heating to 60 ℃, and continuously stirring to melt to obtain a solution B;
step five: mixing the solution A and the solution B obtained in the third step and the fourth step together to obtain a solution C;
step six: adding propylparaben into the solution C obtained in the fifth step, stirring for 30 minutes, heating to 50 ℃, and emulsifying to obtain paste;
step seven: after the emulsified paste is cooled, 5 g of the emulsified paste is canned by a disposable dosing device, and the emulsified paste is packaged.
The method mainly controls the growth and the reproduction of bacteria and viruses in a bacteriostatic way, has no stimulation to the vaginal wall, and plays a role in repairing and conditioning. Can be used for treating abnormal odor of leucorrhea, vaginitis, cervicitis, endometritis, adnexitis, and menoxenia due to ovarian dysfunction in female special region.
And (3) evaluating the clinical trial effect:
case selection: the test subjects were divided into three groups according to age, vaginal condition and specialty, and all the subjects were married women with vaginitis, vaginosis and vaginal pruritus who voluntarily took part in the test over 20 years old.
Wherein the number of people is 60 in a group of 20-30 years old; the number of people is 60 in a group of 30-40 years old, and 60 in a group of 40-50 years old.
The using method comprises the following steps: each test subject served the gynecological anti-bacterial cream prepared in example 3, once a day.
The course of treatment is as follows: and 14 days.
The judgment standard of the curative effect is as follows:
and (3) curing: the symptoms completely disappear after the product is used, and no recrudescer exists after the symptoms are continuously observed for one year;
the effect is shown: the symptoms disappear or are reduced by 80 percent after the product is used;
the method has the following advantages: the symptoms are improved after the product is used, and the symptoms are relieved by more than 40 percent and less than 80 percent;
and (4) invalidation: after 3 courses of treatment, the symptoms are not relieved or aggravated;
according to the evaluation standard, the data result shows that the cure rate reaches 80 percent. The growth and reproduction of bacteria and viruses are controlled in a bacteriostatic way, and the vagina cleaning agent has no stimulation to the vaginal wall, plays a role in repairing and conditioning, has no stimulation and no sensitization, and can be safely used.
The present invention and the embodiments thereof have been described above, but the description is not limited to the embodiments, but only one of the embodiments of the present invention, and the actual embodiments are not limited thereto. In conclusion, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (3)
1. A traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation is characterized by comprising the following components in parts by weight:
20-40 parts of radix sophorae flavescentis, 15-35 parts of fructus kochiae, 2-4 parts of saffron crocus, 15-35 parts of golden cypress, 15-35 parts of fructus cnidii, 20-40 parts of herba patriniae, 10-30 parts of dandelion, 50-150 parts of small molecule active peptide, 50-150 parts of glycerol (glycerin), 50-150 parts of white oil, 50-150 parts of glycerol stearate and 0.5-1.5 parts of nipagin propyl ester.
2. The traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation according to claim 1, which is characterized in that: 30 parts of radix sophorae flavescentis, 25 parts of fructus kochiae, 3 parts of saffron crocus, 25 parts of golden cypress, 25 parts of fructus cnidii, 30 parts of herba patriniae, 20 parts of dandelion, 100 parts of small molecule active peptide, 100 parts of glycerol, 100 parts of white oil, 100 parts of glycerol stearate and 1 part of nipagin propyl ester.
3. A preparation method of a traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation is characterized by comprising the following steps:
the method comprises the following steps: weighing the above traditional Chinese medicine components (radix Sophorae Flavescentis, Kochiae fructus, stigma croci Sativi, cortex Phellodendri, fructus Cnidii, herba Patriniae, and herba Taraxaci) according to weight ratio, wrapping with gauze, tightening, placing into a decocting device, adding 4-6 times of water, boiling with strong fire, decocting for 10-20 minutes, and decocting with slow fire for 30-40 minutes to obtain decoction;
step two: and (4) removing residues, filtering the medicinal liquid obtained in the step (1), and reserving the filtrate for later use.
Step three: sequentially adding the small molecule active peptide and the stearin into the filtrate obtained in the step two, stirring and heating to 80 ℃ until the small molecule active peptide and the stearin are completely dissolved to obtain a solution A;
step four: mixing glycerol (glycerin) and white oil together, heating to 60 ℃, and continuously stirring to melt to obtain a solution B;
step five: mixing the solution A and the solution B obtained in the third step and the fourth step together to obtain a solution C;
step six: adding propylparaben into the solution C obtained in the fifth step, stirring for 30 minutes, heating to 50 ℃, and emulsifying to obtain paste;
step seven: after the emulsified paste is cooled, 5 g of the emulsified paste is canned by a disposable dosing device, and the emulsified paste is packaged.
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