CN106491642A - A kind of sodium alginate antimicrobial spray and preparation method thereof - Google Patents
A kind of sodium alginate antimicrobial spray and preparation method thereof Download PDFInfo
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- CN106491642A CN106491642A CN201611015135.0A CN201611015135A CN106491642A CN 106491642 A CN106491642 A CN 106491642A CN 201611015135 A CN201611015135 A CN 201611015135A CN 106491642 A CN106491642 A CN 106491642A
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- sodium alginate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
Abstract
The invention provides a kind of sodium alginate antimicrobial spray and preparation method thereof, the sodium alginate antimicrobial spray is counted by weight and is made up of following component：95～100 parts of 4～6 parts of sodium alginate, 3～5 parts of water soluble chitosan, 1～3 part of carnosic acid, 2～4 parts of antiseptic, 0.5～5 part of medical glycerine, 0.05～0.2 part of borneol, 0.5～2 part of vitamin A, 0.5～2 part of Cobastab, 0.5～2 part of emulsifying agent, 1～3 part of solubilizer and purified water.The present invention is by adding water soluble chitosan and carnosic acid, using sodium alginate and the synergy of water soluble chitosan, under the booster action of carnosic acid, make obtained sodium alginate antimicrobial spray that not only there is good bactericidal effect, while having into, film persistence is long, long-acting degerming demand can be met.
Description
Technical field
The invention belongs to medical spray field, and in particular to a kind of sodium alginate antimicrobial spray and preparation method thereof.
Background technology
Some wounds, scratch and the pain caused in daily life, needs quickly to be alleviated and treated, Clinical practice
Medicine be mostly paste, patient is very painful when medicine-feeding, and absorbs poor, and drug effect is difficult to play, while having very
The ointment taste of weight, and wound easy infection.
The spray species of the treatment surface of a wound, pain of alleviation and the anti-inflammatory that occur on market is fewer, most of for shitosan spray
Agent or silver ion spray, have no the antimicrobial spray containing alginate or sodium alginate.These sprays be substantially all presence with
Lower problem：(1) comparison of ingredients of spray is single, causes the function of spray relatively simple, lacks polyfunctional spray；(2) resist
Bacterium effect kills Shortcomings in terms of intractable pathogenic bacteria than relatively limited；(3) most of product RT over the course for the treatment of
Shorter, greatly reduce the performance of product function；(4) there is the spray of antibacterial functions, with the increase of resting period, product
Stability declines.(5) most of antiseptic is extracted from plant, there is impurity content height, residual harmful substance etc.
Risk.
CN 105169408A disclose a kind of sodium alginate antimicrobial spray and preparation method thereof, the sodium alginate antibacterial
Spray is counted by weight and is made up of following component：0.1～0.8 part of sodium alginate, 1～6 part of antiseptic, medical glycerine 0.5～5
Part, 0.05～0.2 part of borneol, vitamin A？0.5～2 part, 0.5～2 part of Cobastab, 95～100 parts of purified water.Although it is described
Sodium alginate antimicrobial spray, with preferable antibacterial effect, but which need to be improved into film persistence, it is impossible to meet long-acting degerming
Needs.
Content of the invention
Problem in the presence of for prior art, the invention provides a kind of sodium alginate antimicrobial spray and its preparation side
Method.The present invention passes through to add water soluble chitosan and carnosic acid, using sodium alginate and the synergy of water soluble chitosan,
Under the booster action of carnosic acid, make obtained sodium alginate antimicrobial spray that there is good bactericidal effect not only, while tool
Have into that film persistence is long, long-acting degerming demand can be met.
For solving above-mentioned technical problem, the technical solution used in the present invention is：
In a first aspect, the invention provides a kind of sodium alginate antimicrobial spray, the antimicrobial spray count by weight by
Following component is constituted：
Wherein, the weight portion of sodium alginate can be 4 parts, 4.5 parts, 5 parts, 5.5 parts or 6 parts etc.；The weight of water soluble chitosan
Amount part can be 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts etc.；The weight portion of carnosic acid can be 1 part, 1.5 parts, 2 parts, 2.5 parts or 3
Part etc.；The weight portion of antiseptic can be 2 parts, 3 parts or 4 parts etc.；The weight portion of medical glycerine can be 0.5 part, 1 part, 2 parts, 3 parts, 4
Part or 5 parts etc.；The weight portion of borneol can be 0.05 part, 0.1 part, 0.15 part or 0.2 part etc.；The weight portion of vitamin A can be 0.5
Part, 1 part, 1.5 parts or 2 parts etc.；The weight portion of Cobastab can be 0.5 part, 1 part, 1.5 parts or 2 parts etc.；The weight portion of emulsifying agent
It can be 0.5 part, 1 part, 1.5 parts or 2 parts etc.；The weight portion of solubilizer can be 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts etc.；Purifying
The weight portion of water can be 95 parts, 96 parts, 97 parts, 98 parts, 99 parts or 100 parts etc..
Following as currently preferred technical scheme, but the restriction of the technical scheme provided not as the present invention passes through
Technical scheme below, can preferably reach and realize the technical purpose and beneficial effect of the present invention.
Used as currently preferred technical scheme, the antimicrobial spray is counted by weight and is made up of following component：
Used as currently preferred technical scheme, the sodium alginate is high G/M, wherein G/M=10：5～11：2, high G/
The alginates of M have good haemostatic effect.
Used as currently preferred technical scheme, the purity of the sodium alginate is 100%, is natural biological active matter
Matter, can be degraded and absorbed in human body, promote the healing of wound.
Used as currently preferred technical scheme, the antiseptic is colourless complex state Nano silver solution, and the antiseptic is
Highly stable complex state Nano silver solution, with good sterilizing ability, long-time is placed and will not be changed colour, not oxidized, than
Common coloured monomer nano silver solution or ionic state Nano silver solution antibiotic property is strong tens times, and has rapid sterilizing function；
Used as currently preferred technical scheme, in the colourless complex state Nano silver solution, content of nanometer silver is
1000ppm～3000ppm, particle size range are 1～10nm；Control Nano Silver particle size range, can preferably with sodium alginate in
Reaction is crosslinked, is wrapped in the network structure of sodium alginate, reach the effect of slow release.
Used as currently preferred technical scheme, the purity of described medical glycerine is more than 99.8%, highly purified glycerine
The action time for extending sodium alginate spray can be played again with moisturizing both.
Preferably, the water soluble chitosan is carboxymethyl chitosan.
Preferably, the emulsifying agent is polyglyceryl laurate, polyglycereol myristinate, POGE-A or poly- sweet
In oleostearin acid esters any one or at least two combination；The combination is typical but non-limiting example has：Polyglycereol bay
Acid esters and the combination of the combination of polyglycereol myristinate, POGE-A and polyglycerol stearate, polyglycereol laurate
The combination of ester, polyglycereol myristinate, POGE-A and polyglycerol stearate.
Preferably, the solubilizer is polyoxyethylene hardened castor oil, Emulsifier EL-60, aliphatic alcohol polyethenoxy
In ether, aliphatic alcohol polyethenoxy-polyethenoxy ether, polyoxyethylene sorbitan fatty acid ester or polyglyceryl fatty acid ester arbitrarily
A kind of or at least two combination；The combination is typical but non-limiting examples have：Polyoxyethylene hardened castor oil and polyoxy second
The combination of alkene castor oil, the combination of AEO and aliphatic alcohol polyethenoxy-polyethenoxy ether, polyoxyethylene sorbitan
Span and the combination of polyglyceryl fatty acid ester, polyoxyethylene hardened castor oil, Emulsifier EL-60 and fat
The combination of alcohol APEO, AEO, aliphatic alcohol polyethenoxy-polyethenoxy ether and polyoxyethylene sorbitan mountain
The combination of pears alcohol fatty acid ester, polyoxyethylene hardened castor oil, Emulsifier EL-60, AEO, fatty alcohol
Combination of polyoxyethylene polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester and polyglyceryl fatty acid ester etc., further
Preferably polyoxyethylene hardened castor oil.
Second aspect, the invention provides the preparation method of above-mentioned sodium alginate antimicrobial spray, the preparation method is concrete
Processing step is as follows：
S1. the antiseptic of formula ratio is added in purified water, mixes 2～5min, add the borneol of formula ratio, stir
2～5min is mixed, after dissolving is well mixed, sodium alginate, water soluble chitosan and the carnosic acid of formula ratio is added, mixing is simultaneously
0.5h～1h is to uniform for stirring, standby；
S2. vitamin A, Cobastab, medical glycerine and the purified water of formula ratio are taken, first Cobastab is molten with purified water
Solution, then vitamin A is dissolved with medical glycerine, after both are mixed, 5～8min of stirring is subsequently adding the breast of formula ratio to uniform
Agent and solubilizer, mix 20～30min standby；
S3. solution obtained in solution obtained in S1 and S2 is mixed, and 10～20min is stirred to uniform, in 0.3～
Reacted at 120～150 DEG C under 0.5MPa, be then sub-packed in spray bottle, after radiation sterilization, obtained the alginic acid
Sodium antimicrobial spray.
Wherein, the reaction pressure in S3 can be 0.3MPa, 0.4MPa or 0.5MPa etc.；Reaction temperature can be 120 DEG C, 125
DEG C, 130 DEG C, 135 DEG C, 140 DEG C, 145 DEG C or 150 DEG C etc..
Used as currently preferred technical scheme, the reaction time described in step S3 is 1～3h, such as 1h, 2h or 3h etc..
Beneficial effects of the present invention are：
The present invention passes through to add water soluble chitosan and carnosic acid, using the collaboration of sodium alginate and water soluble chitosan
Effect, under the booster action of carnosic acid, makes obtained sodium alginate antimicrobial spray that not only there is good bactericidal effect, with
When have into that film persistence is long, which can meet long-acting degerming demand into film persistence ＞ 48h.
Specific embodiment
Technical scheme is described further with reference to embodiment.
Embodiment 1
A kind of sodium alginate antimicrobial spray and preparation method thereof is present embodiments provided, the antimicrobial spray is by weight
Meter is made up of following component：
Its preparation method is as follows：
S1. the antiseptic of formula ratio is added in purified water, mixes 3min, then plus formula ratio enter borneol, stirring
3min, after dissolving is well mixed, adds sodium alginate, carboxymethyl chitosan and the carnosic acid of formula ratio, is mixed and stirred for
1h is to uniform, standby；
S2. vitamin A, Cobastab, medical glycerine and the purified water of formula ratio are taken, first Cobastab is molten with purified water
Solution, then vitamin A is dissolved with medical glycerine, after both are mixed, stirring 6min is subsequently adding the emulsification of formula ratio to uniform
Agent and solubilizer, mix 25min standby；
S3. solution obtained in solution obtained in S1 and S2 is mixed, and 15min is stirred to uniform, in 130 under 0.4MPa
Reaction 2h is carried out at DEG C, is then sub-packed in spray bottle, obtain the sodium alginate antimicrobial spray after radiation sterilization.
Obtained in the present embodiment, the performance of sodium alginate antimicrobial spray is as shown in table 1.
Embodiment 2：
A kind of sodium alginate antimicrobial spray and preparation method thereof is present embodiments provided, the antimicrobial spray is by weight
Meter is made up of following component：
Its preparation method is as follows：
S1. the antiseptic of formula ratio is added in purified water, mixes 2min, then plus formula ratio enter borneol, stirring
2min, after dissolving is well mixed, adds sodium alginate, carboxymethyl chitosan and the carnosic acid of formula ratio, is mixed and stirred for
0.5h is to uniform, standby；
S2. vitamin A, Cobastab, medical glycerine and the purified water of formula ratio are taken, first Cobastab is molten with purified water
Solution, then vitamin A is dissolved with medical glycerine, after both are mixed, stirring 5min is subsequently adding the emulsification of formula ratio to uniform
Agent and solubilizer, mix 20min standby；
S3. solution obtained in solution obtained in S1 and S2 is mixed, and 10min is stirred to uniform, in 120 under 0.4MPa
Reaction 1h is carried out at DEG C, is then sub-packed in spray bottle, obtain the sodium alginate antimicrobial spray after radiation sterilization.
Obtained in the present embodiment, the performance of sodium alginate antimicrobial spray is as shown in table 1.
Embodiment 3：
A kind of sodium alginate antimicrobial spray and preparation method thereof is present embodiments provided, the antimicrobial spray is by weight
Meter is made up of following component：
Its preparation method is as follows：
S1. the antiseptic of formula ratio is added in purified water, mixes 5min, then plus formula ratio enter borneol, stirring
5min, after dissolving is well mixed, adds sodium alginate, carboxymethyl chitosan and the carnosic acid of formula ratio, is mixed and stirred for
1h is to uniform, standby；
S2. vitamin A, Cobastab, medical glycerine and the purified water of formula ratio are taken, first Cobastab is molten with purified water
Solution, then vitamin A is dissolved with medical glycerine, after both are mixed, stirring 8min is subsequently adding the emulsification of formula ratio to uniform
Agent and solubilizer, mix 30min standby；
S3. solution obtained in solution obtained in S1 and S2 is mixed, and 20min is stirred to uniform, in 150 under 0.5MPa
Reaction 3h is carried out at DEG C, is then sub-packed in spray bottle, obtain the sodium alginate antimicrobial spray after radiation sterilization.
Obtained in the present embodiment, the performance of sodium alginate antimicrobial spray is as shown in table 1.
Comparative example 1：
Embodiment 1. in CN 105169408A
Comparative example 2：
This comparative example provides a kind of sodium alginate antimicrobial spray, the preparing raw material of the sodium alginate antimicrobial spray and work
With in addition to without water soluble chitosan, unclassified stores consumption is in the same manner as in Example 1 with preparation method.
Obtained in this comparative example, the performance of sodium alginate antimicrobial spray is as shown in table 1.
Comparative example 3：
This comparative example provides a kind of sodium alginate antimicrobial spray, the preparing raw material of the sodium alginate antimicrobial spray and work
With in addition to without carnosic acid, unclassified stores consumption is in the same manner as in Example 1 with preparation method.
Obtained in this comparative example, the performance of sodium alginate antimicrobial spray is as shown in table 1.
Comparative example 4：
This comparative example provides a kind of sodium alginate antimicrobial spray, the preparing raw material of the sodium alginate antimicrobial spray and work
With in addition to without sodium alginate, unclassified stores consumption is in the same manner as in Example 1 with preparation method.
Obtained in this comparative example, the performance of sodium alginate antimicrobial spray is as shown in table 1.
Table 1：The performance table of obtained sodium alginate antimicrobial spray in embodiment 1-3 and comparative example 1-4
The result of integrated embodiment 1-3 and comparative example 1-4 can be seen that the present invention by adding water soluble chitosan and mouse
Tail oxalic acid, using sodium alginate and the synergy of water soluble chitosan, under the booster action of carnosic acid, makes obtained sea
Mosanom antimicrobial spray not only has good bactericidal effect, while it is long that there is into film persistence, its into film persistence ＞ 48h,
Long-acting degerming demand can be met.
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not right
The restriction of embodiments of the present invention；For those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms, there is no need to be exhaustive to all of embodiment；All this
Any modification, equivalent and improvement that is made within the spirit and principle of invention etc., should be included in the claims in the present invention
Protection domain within.
Claims (8)
1. a kind of sodium alginate antimicrobial spray, it is characterised in that the antimicrobial spray is counted by weight and is made up of following component：
2. antimicrobial spray according to claim 1, it is characterised in that the antimicrobial spray count by weight by following into
Divide and constitute：
3. antimicrobial spray according to claim 1 and 2, it is characterised in that described sodium alginate is high G/M alginic acids
Sodium, G/M=10:5～11:2.
4. the antimicrobial spray according to any one of claim 1-3, it is characterised in that the purity of the sodium alginate is
100%.
5. the antimicrobial spray according to any one of claim 1-4, it is characterised in that the antiseptic is received for colourless complex state
The silver-colored solution of rice.
6. the antimicrobial spray according to any one of claim 1-5, it is characterised in that the colourless complex state Nano silver solution
Middle content of nanometer silver is 1000ppm～3000ppm, and particle size range is 1～10nm；
Preferably, the purity of described medical glycerine is more than 99.8%；
Preferably, the water soluble chitosan is carboxymethyl chitosan；
Preferably, the emulsifying agent is that polyglyceryl laurate, polyglycereol myristinate, POGE-A or polyglycereol are hard
In resin acid ester any one or at least two combination；
Preferably, the solubilizer is polyoxyethylene hardened castor oil, Emulsifier EL-60, AEO, fat
In fat alcohol polyoxyethylene polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester or polyglyceryl fatty acid ester any one
Or at least two combination.
7. a kind of preparation method of the sodium alginate antimicrobial spray as described in any one of claim 1-6, it is characterised in that described
Preparation method concrete technology step is as follows：
S1. the antiseptic of formula ratio is added in purified water, mixes 2～5min, then plus formula ratio enter borneol, stirring 2
～5min, after dissolving is well mixed, adds sodium alginate, water soluble chitosan and the carnosic acid of formula ratio, mixes and stir
0.5h～1h is mixed to uniform, standby；
S2. vitamin A, Cobastab, medical glycerine and the purified water of formula ratio is taken, first Cobastab is dissolved with purified water, then
Vitamin A is dissolved with medical glycerine, after both are mixed, 5～8min of stirring is subsequently adding the emulsifying agent of formula ratio to uniform
And solubilizer, mix 20～30min standby；
S3. solution obtained in solution obtained in S1 and S2 is mixed, and 10～20min is stirred to uniform, under 0.3～0.5MPa
Reacted at 120～150 DEG C, be then sub-packed in spray bottle, after radiation sterilization, obtained the sodium alginate antibacterial spray
Agent.
8. preparation method according to claim 7, it is characterised in that the reaction time described in step S3 is 1～3h.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611015135.0A CN106491642A (en) | 2016-11-18 | 2016-11-18 | A kind of sodium alginate antimicrobial spray and preparation method thereof |
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| CN201611015135.0A CN106491642A (en) | 2016-11-18 | 2016-11-18 | A kind of sodium alginate antimicrobial spray and preparation method thereof |
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| CN109203323A (en) * | 2018-08-21 | 2019-01-15 | 费宇奇 | A kind of preparation method of the degradable medical catheter of environmental protection |
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Application publication date: 20170315 |