CN108743702A - A kind of anti-haze poison spray and preparation method thereof - Google Patents
A kind of anti-haze poison spray and preparation method thereof Download PDFInfo
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- CN108743702A CN108743702A CN201810590529.1A CN201810590529A CN108743702A CN 108743702 A CN108743702 A CN 108743702A CN 201810590529 A CN201810590529 A CN 201810590529A CN 108743702 A CN108743702 A CN 108743702A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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Abstract
The invention discloses a kind of anti-haze poison sprays and preparation method thereof, main component is sodium alginate, tea polyphenols and grapefruit seed extract using water for injection or purified water as carrier, it is formulated, the anti-haze poison spray is suitable for prevention and treatment viral infection of upper respiratory tract, bird flu, hand-foot-and-mouth disease, and PM2.5 harmful substances in air is blocked to pass through respiratory mucosa and pulmonary absorption；It can also be painted in mask, the entrance of germ is blocked from breathing source.In addition, the anti-haze poison spray of the present invention is non-toxic to human body, mucous membrane is nonirritant, without sensitization, there is good biological degradability, good antibacterial, antiviral, anti-inflammatory analgetic, the effect of pre- haze.
Description
Technical field
The present invention relates to a kind of anti-haze poison sprays and preparation method thereof, belong to prevention and treatment viral infection of upper respiratory tract
Spray formulation.
Background technology
Contain a large amount of sulfur dioxide, nitrogen oxides and pellet in haze, these particulate matters pass in air
It broadcasts, the attachment of a large amount of germs can be caused further to multiply, propagated in air, seriously affect the health of some Susceptible population, disease
Sick rate increases, and especially in some haze weathers, air pressure reduction, Inhalable Particulate abruptly increase, air flow property are poor, have
Evil bacterium and virus slow to what surrounding was spread, cause virus concentration in air to increase, the risk of transmission is very high.
Virus flu, influenza and hand-foot-and-mouth disease are mostly to carry out viral transmission by oral cavity and respiratory tract, this
A little viruses are attached on the particulate matter in haze, and after being breathed by people, propagation is more difficult to control, and harm is very big, or even will appear weight
Disease case（Severe pneumonia, respiratory failure etc.）.Especially illness rate highest of the hand-foot-and-mouth disease with children, mostly occur in 5 years old with
There are exanthema vesiculosum or aphtha, most infants one week or so in lower children, the positions such as performance stomatalgia, apocleisis, low-heat, hand, foot, oral cavity
Self-healing, a small number of infants can cause the complication such as myocarditis, pulmonary edema, aseptic meningoencephalitis.Individual children with serious disease progression of the disease
Soon, lead to death.Lack the main symptomatic treatment of effective medicine at present.
Mostly do not have sterilization, antivirus action, also some cottons to block based on particulate matter on existing haze mask
The mask people of matter can reuse, so that some viruses remain in the position of breathing of mouth and nose for a long time, can not reach
To protective action, if used to child after adult's use, it can more cause the propagation of germ.
Invention content
For overcome the deficiencies in the prior art, the present invention provides a kind of suitable for prevention and treatment viral upper respiratory sense
Dye, bird flu, hand-foot-and-mouth disease block PM2.5 harmful substances in air to pass through respiratory mucosa and pulmonary absorption；It can also be direct
It is sprayed in mask, the entrance of germ is blocked from breathing source.
The present invention is achieved through the following technical solutions, and a kind of anti-haze poison spray, each component and its mass fraction are：
Sodium alginate 0.1-4.0%；
Grapefruit seed extract 0.01-10.0%；
Tea polyphenols 0.01-5.0%；
Chloride, and amount of chloride ions is in aqueous solution： 0.4%—0.9%；
Adjust osmotic pressure substance：Glycine 1.0-2.0%；
Water for injection or purified water：Surplus.
As a kind of prioritization scheme of anti-haze poison spray of the present invention, the alginate is water soluble algae acid
Sodium.
As a kind of prioritization scheme of anti-haze poison spray of the present invention, the chloride includes sodium chloride, chlorination
Potassium, calcium chloride, magnesium chloride, one or more of zinc chloride.
A kind of preparation method of anti-haze poison spray, prepares as follows：
Step 1）Sodium alginate is dissolved in water for injection or purified water, obtains solution 1., it is spare；
Step 2）Chloride is dissolved in water for injection or purified water and obtains solution 2., it is spare；
Step 3）Glycine is dissolved in water for injection or purified water and obtains solution 3., it is spare；
Step 4）Tea polyphenols are dissolved in water for injection or purified water and obtain solution 4., it is spare；
Step 5）1. by solution, solution 2., solution 3. with solution 4. after mixing, grapefruit seed extract is added, passes through
Water for injection or purified water are added after emulsification forms uniform sol form liquid system, after boiling 30 minutes to enough；
Step 6）By step 5）The solution of gained through filter, refined filtration, after 115 DEG C of wet-hot steams, 30 minutes sterilizations at
Product.
By above-mentioned preparation method, it is prepared into a kind of isotonic sterilizing, the viscous liquid of water white transparency, tool
Have and prevent and treat viral infection of upper respiratory tract, bird flu, hand-foot-and-mouth disease, PM2.5 harmful substances are by exhaling in blocking air
Inhale road mucous membrane and pulmonary absorption.
Its mechanism of action is as follows：
1, physical biological barrier effect：Sodium alginate is natural polymer, and there is certain viscosity easily to form biology
Film forms a kind of biological glued membrane in skin and respiratory mucosa rapidly, mucous membrane is made to be isolated with extraneous bacterium, virus, haze substance,
Play physical biological barrier effect.
2, antibacterial, virus function：Important component is in invention composition：Grapefruit seed extract main component is compound
Xenol aminobenzene belongs to polyphenols, have ionic surface active agent property is easily formed micelle carry higher negative electrical charge by
It is acted in electrostatic attraction, a pile positive charge can be attracted around micelle, some is positive and negative to cancel out each other, in addition sodium alginate point
Subband has positive charge, thus high positive charge group is still formed around micelle.Virus is a kind of acellular form of life, it is by one
A nucleic acid long-chain and protein coat are constituted, and parasitize host cell, and into after host cell, it can be utilized in cell
The ability of matter and energy and duplication, transcription and translation, the hereditary information that the nucleic acid according to own is included generates and it
The same a new generation's virus.Once into once after host cell at without any vital movement, can not Independent self breed
Chemical substance place one's entire reliance upon host cell.Other cells are parasitized due to being made of a nucleic acid long-chain and protein coat
To make host cell wall charge polarity change present negative electrical charge it is similar with bacteria cell wall charge polarity.Carefully
Bacterium, viral micro-organisms with negative electrical charge by coulomb force effect by bacterium, viruses adsorption around micelle, form a kind of biomembrane
Bacteria wall, virocyte core are wrapped up.Block bacterium, virocyte ectendotrophy substance transportation.Interfere bacterium, virus it is normal
Metabolism, to kill bacterium, viral growth.
3, the effect of upper respiratory tract environmental balance is adjusted：Come from fruit grape fruit containing grapefruit seed extract in product
A kind of middle sterilization of extraction（Or it is antibacterial）" fruit sterilization factors ".Belong to polyphenols this " fruit sterilization factors " on the one hand to have
Have and inhibits pathogenic microorganisms growth；On the other hand have and promote beneficial bacterium growth.Therefore with adjusting oral cavity.Colony balance is made
With.There is scavenging activated oxygen effect simultaneously.
4, clean and keep mucous membrane humidification：The water-soluble glue of chitosan is exactly a kind of adjusting ecological balance, oral cavity and nose
Chamber flora, the isotonic product of external application of acid-base balance, it can automatically adjust rapidly intraoral soda acid and colony balance, promote mucous membrane
The absorption of its active oxygen organized can form biomembrane in oral mucosal surface rapidly and be covered in respiratory mucosa surface, to
Mucous membrane surface cell water loss is reduced, moistening effect is reached.
The physical and chemical index of products obtained therefrom is：
1, appearance is colourless transparent liquid
2, light transmittance >=95%
3, pH value 4.5-7.5
4, dynamic viscosity >=10mpas
5, content of beary metal≤0.001%
The beneficial effects of the invention are as follows：The anti-haze poison spray produced by above-mentioned preparation process and method, be to human body without
Toxicity, it is nonirritant, without sensitivity response and with prevention and treatment viral infection of upper respiratory tract, bird flu, hand-foot-and-mouth disease, resistance
PM2.5 harmful substances pass through respiratory mucosa and pulmonary absorption in disconnected air.
In order to achieve the above purpose, the technical solution adopted in the present invention is：Polymeric biomaterial is passed through above-mentioned
Preparation method be configured to a kind of isotonic sterile solution, the physical and chemical index of this product meets《People's Republic of China's medicine
Allusion quotation》Relevant requirement.
The bio-safety performance index of this product：
Acute systemic toxicity, result are：Practical nontoxic grade；
Cell toxicity test, result are：1 grade；
Priming experiments, result are：Nothing；
Intradermal irritation test, result are：Nothing.
Mucous membrane of mouth irritation test is feminine gender
The beneficial effects of the invention are as follows：The anti-haze poison spray produced by above-mentioned preparation process and method, be to human body without
Toxicity, it is nonirritant, without sensitivity response and with prevention and treatment viral infection of upper respiratory tract, bird flu, hand-foot-and-mouth disease, resistance
PM2.5 harmful substances pass through respiratory mucosa and pulmonary absorption in disconnected air.
In order to achieve the above purpose, the technical solution adopted in the present invention is：Polymeric biomaterial is passed through above-mentioned
Preparation method be configured to a kind of isotonic sterile solution, the physical and chemical index of this product meets《People's Republic of China's medicine
Allusion quotation》Relevant requirement.
Above-mentioned biological property index is detected by specified inspection body of country, standard compliant relevant regulations.
Specific implementation mode
With reference to example the method and advantageous effect that the present invention is further explained.
Embodiment 1
A kind of anti-haze poison spray, each component and its mass fraction are：
Sodium alginate 0.4%；
Grapefruit seed extract 7.0%；
Tea polyphenols 2.0%；
Sodium chloride, and amount of chloride ions is in aqueous solution： 0.4%；
Adjust osmotic pressure substance：Glycine 1.0%；
Water for injection or purified water：Surplus.
The alginate is water soluble algae acid sodium.
A kind of preparation method of anti-haze poison spray, prepares as follows：
Step 1）Sodium alginate is dissolved in water for injection or purified water, obtains solution 1., it is spare；
Step 2）Sodium chloride is dissolved in water for injection or purified water and obtains solution 2., it is spare；
Step 3）Glycine is dissolved in water for injection or purified water and obtains solution 3., it is spare；
Step 4）Tea polyphenols are dissolved in water for injection or purified water and obtain solution 4., it is spare；
Step 5）1. by solution, solution 2., solution 3. with solution 4. after mixing, grapefruit seed extract is added, passes through
Water for injection or purified water are added after emulsification forms uniform sol form liquid system, after boiling 30 minutes to enough；
Step 6）By step 5）The solution of gained through filter, refined filtration, after 115 DEG C of wet-hot steams, 30 minutes sterilizations at
Product.
Embodiment 2
A kind of anti-haze poison spray, each component and its mass fraction are：
Sodium alginate 3.0%；
Grapefruit seed extract 4.0%；
Tea polyphenols 1.5%；
Chloride, and amount of chloride ions is in aqueous solution： 0.4%；
Adjust osmotic pressure substance：Glycine 1.2%；
Water for injection or purified water：Surplus.
The alginate is water soluble algae acid sodium.
The chloride is both potassium chloride and zinc chloride according to mass ratio 4:6 mix.
A kind of preparation method of anti-haze poison spray, prepares as follows：
Step 1）Sodium alginate is dissolved in water for injection or purified water, obtains solution 1., it is spare；
Step 2）Chloride is dissolved in water for injection or purified water and obtains solution 2., it is spare；
Step 3）Glycine is dissolved in water for injection or purified water and obtains solution 3., it is spare；
Step 4）Tea polyphenols are dissolved in water for injection or purified water and obtain solution 4., it is spare；
Step 5）1. by solution, solution 2., solution 3. with solution 4. after mixing, grapefruit seed extract is added, passes through
Water for injection or purified water are added after emulsification forms uniform sol form liquid system, after boiling 30 minutes to enough；
Step 6）By step 5）The solution of gained through filter, refined filtration, after 115 DEG C of wet-hot steams, 30 minutes sterilizations at
Product.
Embodiment 3
A kind of anti-haze poison spray, each component and its mass fraction are：
Sodium alginate 3.6%；
Grapefruit seed extract 9.0%；
Tea polyphenols 0.05%；
Chloride, and amount of chloride ions is in aqueous solution： 0.9%；
Adjust osmotic pressure substance：Glycine 1.0%；
Water for injection or purified water：Surplus.
The alginate is water soluble algae acid sodium.
The chloride is sodium chloride, and magnesium chloride and zinc chloride three are according to mass ratio 4:：2：4 are mixed.
A kind of preparation method of anti-haze poison spray, prepares as follows：
Step 1）Sodium alginate is dissolved in water for injection or purified water, obtains solution 1., it is spare；
Step 2）Chloride is dissolved in water for injection or purified water and obtains solution 2., it is spare；
Step 3）Glycine is dissolved in water for injection or purified water and obtains solution 3., it is spare；
Step 4）Tea polyphenols are dissolved in water for injection or purified water and obtain solution 4., it is spare；
Step 5）1. by solution, solution 2., solution 3. with solution 4. after mixing, grapefruit seed extract is added, passes through
Water for injection or purified water are added after emulsification forms uniform sol form liquid system, after boiling 30 minutes to enough；
Step 6）By step 5）The solution of gained through filter, refined filtration, after 115 DEG C of wet-hot steams, 30 minutes sterilizations at
Product.
Whether reach expected invention effect for the anti-haze poison spray of the verification present invention, the anti-haze poison spray of the present invention is resisted
Bacterium is tested, and bacteriostasis rate result is as follows：
Note, the above-mentioned experiment that bacteriostasis rate is carried out just for relatively conventional germ, the present invention can antibacterial type do not limit to
In this.
Claims (4)
1. a kind of anti-haze poison spray, it is characterised in that：Each component and its mass fraction are：
Sodium alginate 0.1-4.0%；
Grapefruit seed extract 0.01-10.0%；
Tea polyphenols 0.01-5.0%；
Chloride, and amount of chloride ions is in aqueous solution： 0.4%—0.9%；
Adjust osmotic pressure substance：Glycine 1.0-2.0%；
Water for injection or purified water：Surplus.
2. anti-haze poison spray according to claim 1, it is characterised in that：The alginate is water soluble algae acid
Sodium.
3. anti-haze poison spray according to claim 1, it is characterised in that：The chloride includes sodium chloride, potassium chloride,
Calcium chloride, magnesium chloride, one or more of zinc chloride.
4. a kind of a kind of preparation method of anti-haze poison spray as described in claim 1, it is characterised in that：It makes as follows
It is standby：
Step 1）Sodium alginate is dissolved in water for injection or purified water, obtains solution 1., it is spare；
Step 2）Chloride is dissolved in water for injection or purified water and obtains solution 2., it is spare；
Step 3）Glycine is dissolved in water for injection or purified water and obtains solution 3., it is spare；
Step 4）Tea polyphenols are dissolved in water for injection or purified water and obtain solution 4., it is spare；
Step 5）1. by solution, solution 2., solution 3. with solution 4. after mixing, grapefruit seed extract is added, passes through
Water for injection or purified water are added after emulsification forms uniform sol form liquid system, after boiling 30 minutes to enough；
Step 6）By step 5）The solution of gained through filter, refined filtration, after 115 DEG C of wet-hot steams, 30 minutes sterilizations at
Product.
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| CN201810590529.1A CN108743702A (en) | 2018-06-09 | 2018-06-09 | A kind of anti-haze poison spray and preparation method thereof |
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| CN201810590529.1A CN108743702A (en) | 2018-06-09 | 2018-06-09 | A kind of anti-haze poison spray and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109985471A (en) * | 2019-04-25 | 2019-07-09 | 吉首大学 | A kind of tea polyphenol nano is except haze particle solution and its preparation method and purposes |
| CN110052087A (en) * | 2019-05-05 | 2019-07-26 | 深圳市寰保化工科技有限公司 | A kind of PM2.5 flocculating agent and preparation method thereof |
| CN110548019A (en) * | 2019-09-12 | 2019-12-10 | 芜湖莱博生物医药有限公司 | Macromolecular polysaccharide for adsorbing inhalable particles in respiratory tract |
| CN111202101A (en) * | 2020-02-13 | 2020-05-29 | 广西中医药大学 | Anti-fogging disposable mask preparation liquid and preparation method thereof |
| CN111345288A (en) * | 2020-03-12 | 2020-06-30 | 优仕康生（天津）科技发展有限公司 | A colloidal carrier capable of forming antibacterial and antiviral coating on the surface of respiratory protector, colloidal tincture and application thereof |
| CN113209219A (en) * | 2021-04-19 | 2021-08-06 | 芳华国际控股(广东)有限公司 | An antiviral aqueous solution for preventing or treating respiratory viral infection |
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| CN105169408A (en) * | 2015-10-13 | 2015-12-23 | 广东泰宝医疗科技股份有限公司 | Sodium alginate antibiosis spray and preparation method thereof |
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| CN105169408A (en) * | 2015-10-13 | 2015-12-23 | 广东泰宝医疗科技股份有限公司 | Sodium alginate antibiosis spray and preparation method thereof |
| CN106962420A (en) * | 2017-05-16 | 2017-07-21 | 广州肽然生物科技有限公司 | A kind of disposable thimerosal based on plant extracts and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109985471A (en) * | 2019-04-25 | 2019-07-09 | 吉首大学 | A kind of tea polyphenol nano is except haze particle solution and its preparation method and purposes |
| CN110052087A (en) * | 2019-05-05 | 2019-07-26 | 深圳市寰保化工科技有限公司 | A kind of PM2.5 flocculating agent and preparation method thereof |
| CN110548019A (en) * | 2019-09-12 | 2019-12-10 | 芜湖莱博生物医药有限公司 | Macromolecular polysaccharide for adsorbing inhalable particles in respiratory tract |
| CN111202101A (en) * | 2020-02-13 | 2020-05-29 | 广西中医药大学 | Anti-fogging disposable mask preparation liquid and preparation method thereof |
| CN111345288A (en) * | 2020-03-12 | 2020-06-30 | 优仕康生（天津）科技发展有限公司 | A colloidal carrier capable of forming antibacterial and antiviral coating on the surface of respiratory protector, colloidal tincture and application thereof |
| CN113209219A (en) * | 2021-04-19 | 2021-08-06 | 芳华国际控股(广东)有限公司 | An antiviral aqueous solution for preventing or treating respiratory viral infection |
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Application publication date: 20181106 |