CN111202101A - Anti-fogging disposable mask preparation liquid and preparation method thereof - Google Patents
Anti-fogging disposable mask preparation liquid and preparation method thereof Download PDFInfo
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- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses an anti-fogging disposable mask preparation liquid, which comprises the following components: concentration greater than 0.5% × 2‑9Vinegar of g/mlChlorhexidine acetate physiological saline solution, Chinese herbal medicine extract, liquid glycerin and aloe essential oil; the mass ratio of the chlorhexidine acetate physiological saline solution to the Chinese herbal medicine extract is 1: 2-1: 3; 3.125g to 4g of liquid glycerin and 0.5g to 1g of aloe essential oil are added into per 100ml of the chlorhexidine acetate physiological saline solution. The preparation liquid is prepared by the following steps: s1, preparing a chlorhexidine acetate normal saline solution, and placing the chlorhexidine acetate normal saline solution in a sterile environment for use; s2, preparing fresh penthorum chinense Pursh and herba Pogostemonis into Chinese herbal medicine extract; s3, mixing the chlorhexidine acetate normal saline solution with the Chinese herbal medicine extract to obtain a mixed solution; s4, adding 3.125g to 4g of liquid glycerol and 0.5g to 1g of aloe essential oil into each 100ml of mixed solution, uniformly mixing, and filling into a sterile spray container. The prepared solution has the effects of inhibiting bacteria and preventing lens fogging, and can inhibit and kill bacteria outside.
Description
Technical Field
The invention belongs to the technical field of mask spraying, and particularly relates to an anti-fogging disposable mask preparation liquid and a preparation method thereof.
Background
The disposable mask has the characteristics of cleanness, sanitation, convenient use, good ventilation performance, bacteria resistance and the like, and the correct wearing of the mask can effectively prevent partial diseases transmitted through respiratory tract and oral cavity, so the disposable mask is widely applied to the working process of clinical medical care personnel. The results of the small-scale questionnaire show that: the existing disposable mask has the defects of short bacteriostatic time, poor bacteriostatic effect, easy lens fogging caused by hot air generated by breathing and the like. Although emerging gauze masks are researched in many types at present, dust-proof and haze-proof gauze masks are mainly used, and antibacterial gauze masks and lens-fogging-proof gauze masks are researched in a few ways. Therefore, the bacteriostatic and anti-fogging disposable mask meeting the use requirements of a user has certain market requirements, but the cost of the bacteriostatic and anti-fogging disposable mask is too high, and if the bacteriostatic and anti-fogging disposable mask is worn only by ordinary people, the bacteriostatic and anti-fogging disposable mask cannot be switched randomly, so that the bacteriostatic and anti-fogging preparation liquid provided by the invention can be used for spraying or not spraying according to different use environments.
Disclosure of Invention
The invention aims to provide an anti-fogging disposable mask preparation liquid and a preparation method thereof, the preparation liquid has the effects of inhibiting bacteria and preventing lens fogging, can inhibit and kill bacteria on the outside, and simultaneously has the effects of moisturizing and skin-friendly on one side of the mask contacting with the face, so that the facial injury caused by wearing the mask for a long time can be prevented.
In order to achieve the purpose, the invention adopts the technical scheme that: an anti-fogging disposable mask preparation liquid comprises the following components: concentration greater than 0.5% × 2-9A g/ml physiological saline solution of chlorhexidine acetate, Chinese herbal medicine extract, liquid glycerin and aloe essential oil;
the mass ratio of the chlorhexidine acetate physiological saline solution to the Chinese herbal medicine extract is 1: 2-1: 3;
3.125g to 4g of liquid glycerin and 0.5g to 1g of aloe essential oil are added into per 100ml of the chlorhexidine acetate physiological saline solution.
The technical scheme of further improvement in the technical scheme is as follows:
1. in the scheme, the Chinese herbal medicine extract comprises wrinkled gianthyssop herb and penthorum chinense pursh, and the mass ratio of the penthorum chinense pursh to the wrinkled gianthyssop herb is 1: 1.
2. In the scheme, the concentration of the chlorhexidine acetate normal saline solution is 0.5 percent multiplied by 2-9g/ml～0.5％×2-6g/ml。
3. In the scheme, the preparation liquid is used for spraying to the center of the inner cover surface of the mask or the center of the inner core of the mask, and has the functions of bacteriostasis and lens fogging prevention.
The other technical scheme of the invention is as follows: a preparation method of an anti-fogging disposable mask preparation liquid is disclosed, wherein the preparation liquid is prepared by the following steps:
s1, preparing a chlorhexidine acetate normal saline solution, and placing the chlorhexidine acetate normal saline solution in a sterile environment for use;
s2, cleaning and airing fresh penthorum chinense pursh and agastache rugosus, respectively crushing to 100-200 meshes, and uniformly mixing the raw material powder according to the mass ratio of 1:1 after crushing;
s3, adding 75% ethanol aqueous solution with the weight 10 times of that of the raw material powder into the mixed raw material powder, performing ultrasonic extraction, performing suction filtration, recovering ethanol, and concentrating to obtain a Chinese herbal medicine extract;
s4, mixing the chlorhexidine acetate normal saline solution with the Chinese herbal medicine extract according to the mass ratio of 1: 2-1: 3 to obtain a mixed solution;
s5, adding 3.125g to 4g of liquid glycerol and 0.5g to 1g of aloe essential oil into each 100ml of mixed solution, uniformly mixing by using a shaker, sterilizing for 20 to 25min by using high-pressure steam at the temperature of 121 to 130 ℃, and then filling into an aseptic spray container.
The technical scheme of further improvement in the technical scheme is as follows:
1. in the scheme, the preparation method of the chlorhexidine acetate normal saline solution in the S1 comprises the following steps:
s01, taking 100ml of sterile normal saline on a super clean bench, and dissolving 0.5g of chlorhexidine acetate in a beaker;
s02, placing 1ml of the solution in another beaker, adding less than 511ml of normal saline, and stirring to obtain appropriate amount of solution with concentration of more than 0.5% x 2-9And g/ml of chlorhexidine acetate normal saline solution is placed in a sterile environment for later use.
2. In the scheme, the ultrasonic power in S3 is set to 375W, and the extraction is carried out for 30min under the environment with the temperature of 55 ℃.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:
the invention relates to an anti-fogging disposable mask preparation and a preparation method thereof, wherein glycerol, penthorum chinense pursh, agastache rugosus and aloe essential oil are added into chlorhexidine acetate physiological saline solution to prepare the preparation, the preparation can be carried about, when in use, a bottle body is shaken and sprayed to the center of the inner cover surface of a mask or the center of the inner core of a part of special mask to replace the original mask interlayer, so that the mask has the effects of inhibiting bacteria and preventing lens fogging, the effects of inhibiting and killing bacteria on external bacteria can be achieved, meanwhile, the side of the mask, which is in contact with the face, has the effects of moisturizing and skin-friendly, and the facial injury caused by wearing the mask for a long time can be prevented; furthermore, the liquid spray has the functions of refreshing and restoring consciousness, and prevents unsmooth breathing caused by wearing the mask for a long time; the preparation method of the preparation liquid is simple, the cost is low, the preparation liquid can be widely applied to hospitals or places with dense population, great convenience is provided for users, the users can select whether to spray the preparation liquid according to the difference of wearing environments, and the use is very convenient.
Detailed Description
The invention is further described below with reference to the following examples:
example 1: an anti-fogging disposable mask preparation liquid comprises the following components: concentration greater than 0.5% × 2-9The mask comprises g/ml chlorhexidine acetate normal saline solution, wrinkled gianthyssop herb, penthorum chinense pursh, liquid glycerin and aloe essential oil, wherein the prepared solution is used for spraying to the center of an inner mask surface or the center of an inner core of the mask and has the functions of inhibiting bacteria and preventing lenses from fogging, and the prepared solution is prepared by the following steps:
s1, on a super clean bench, taking 100ml of sterile normal saline, dissolving 0.5g of chlorhexidine acetate in a beaker, taking 1ml of the solution in another beaker, adding 63ml of normal saline, and uniformly stirring to obtain a proper amount of normal saline with the concentration of 0.5% multiplied by 2-6g/ml of chlorhexidine acetate normal saline solution is placed in a sterile environment for standby;
s2, cleaning and airing fresh penthorum chinense pursh and agastache rugosus, respectively crushing to 100 meshes, and uniformly mixing raw material powder according to a mass ratio of 1:1 after crushing;
s3, adding 75% ethanol aqueous solution with the weight 10 times of that of the raw material powder into the mixed raw material powder, performing ultrasonic extraction, performing suction filtration, recovering ethanol, concentrating, setting the ultrasonic power at 375W, and extracting at 55 ℃ for 30min to obtain a Chinese herbal medicine extract;
s4, mixing the chlorhexidine acetate normal saline solution with the Chinese herbal medicine extract according to the mass ratio of 1:2 to obtain a mixed solution;
s5, adding 3.125g of liquid glycerin and 1g of aloe essential oil into each 100ml of mixed solution, uniformly mixing by using a shaker, sterilizing by high-pressure steam at 121 ℃ for 20min, and then filling into a sterile spray container.
The liquid has antibacterial and antifogging effects, and is suitable for various common masks. Before use, the bottle body is shaken and sprayed with a proper amount of spray to the center of the inner cover surface of the mask to be used, or the inner core can be detached from part of special masks (such as the masks with detachable inner cores) and sprayed to the center of the inner core, and the bottle body is used after standing for 1 minute after the spraying is finished, so that an inexperienced user can use the bottle body after the bottle body is completely volatilized and dried.
Example 2: an anti-fogging disposable mask preparation liquid comprises the following components: concentration greater than 0.5% × 2-9The mask comprises g/ml chlorhexidine acetate normal saline solution, wrinkled gianthyssop herb, penthorum chinense pursh, liquid glycerin and aloe essential oil, wherein the prepared solution is used for spraying to the center of an inner mask surface or the center of an inner core of the mask and has the functions of inhibiting bacteria and preventing lenses from fogging, and the prepared solution is prepared by the following steps:
s1, on a super clean bench, taking 100ml of sterile normal saline, dissolving 0.5g of chlorhexidine acetate in a beaker, taking 1ml of the solution in another beaker, adding 511ml of normal saline, and uniformly stirring to obtain a proper amount of normal saline with the concentration of 0.5% multiplied by 2-9g/ml of chlorhexidine acetate normal saline solution is placed in a sterile environment for standby;
s2, cleaning and airing fresh penthorum chinense pursh and agastache rugosus, respectively crushing to 200 meshes, and uniformly mixing raw material powder according to a mass ratio of 1:1 after crushing;
s3, adding 75% ethanol aqueous solution with the weight 10 times of that of the raw material powder into the mixed raw material powder, performing ultrasonic extraction, performing suction filtration, recovering ethanol, concentrating, setting the ultrasonic power at 375W, and extracting at 55 ℃ for 30min to obtain a Chinese herbal medicine extract;
s4, mixing the chlorhexidine acetate normal saline solution with the Chinese herbal medicine extract according to the mass ratio of 1:3 to obtain a mixed solution;
s5, adding 4g of liquid glycerol and 0.5g of aloe essential oil into each 100ml of mixed solution, uniformly mixing by using a shaker, sterilizing by high-pressure steam at 130 ℃ for 25min, and then filling into a sterile spray container.
The liquid has antibacterial and antifogging effects, and is suitable for various common masks. Before use, the bottle body is shaken and sprayed with a proper amount of spray to the center of the inner cover surface of the mask to be used, or the inner core can be detached from part of special masks (such as the masks with detachable inner cores) and sprayed to the center of the inner core, and the bottle body is used after standing for 1 minute after the spraying is finished, so that an inexperienced user can use the bottle body after the bottle body is completely volatilized and dried.
Example 3: an anti-fogging disposable mask preparation liquid comprises the following components:concentration greater than 0.5% × 2-9The mask comprises g/ml chlorhexidine acetate normal saline solution, wrinkled gianthyssop herb, penthorum chinense pursh, liquid glycerin and aloe essential oil, wherein the prepared solution is used for spraying to the center of an inner mask surface or the center of an inner core of the mask and has the functions of inhibiting bacteria and preventing lenses from fogging, and the prepared solution is prepared by the following steps:
s1, on a super clean bench, taking 100ml of sterile normal saline, dissolving 0.5g of chlorhexidine acetate in a beaker, taking 1ml of the solution in another beaker, adding 127ml of normal saline, and uniformly stirring to obtain a proper amount of normal saline with the concentration of 0.5% multiplied by 2-7g/ml of chlorhexidine acetate normal saline solution is placed in a sterile environment for standby;
s2, cleaning and airing fresh penthorum chinense pursh and agastache rugosus, respectively crushing to 120 meshes, and uniformly mixing raw material powder according to a mass ratio of 1:1 after crushing;
s3, adding 75% ethanol aqueous solution with the weight 10 times of that of the raw material powder into the mixed raw material powder, performing ultrasonic extraction, performing suction filtration, recovering ethanol, concentrating, setting the ultrasonic power at 375W, and extracting at 55 ℃ for 30min to obtain a Chinese herbal medicine extract;
s4, mixing the chlorhexidine acetate normal saline solution with the Chinese herbal medicine extract according to the mass ratio of 1:2.5 to obtain a mixed solution;
s5, adding 3.5g of liquid glycerin and 0.5g of aloe essential oil into each 100ml of mixed solution, uniformly mixing by using a shaker, sterilizing by high-pressure steam at 125 ℃ for 20min, and then filling into a sterile spray container.
The liquid has antibacterial and antifogging effects, and is suitable for various common masks. Before use, the bottle body is shaken and sprayed with a proper amount of spray to the center of the inner cover surface of the mask to be used, or the inner core can be detached from part of special masks (such as the masks with detachable inner cores) and sprayed to the center of the inner core, and the bottle body is used after standing for 1 minute after the spraying is finished, so that an inexperienced user can use the bottle body after the bottle body is completely volatilized and dried.
The above-mentioned aspects of the invention are further explained as follows:
firstly, determining the concentration of the chlorhexidine acetate physiological saline solution:
1. test drugs: chlorhexidine acetate (chlorhexidine acetate), Shandong Yousio chemical science and technology Limited, pharmaceutical grade, with an effective content of greater than or equal to 97.5%. Glycerol, wuyi yanwei science and technology ltd, pharmaceutical grade.
2. The test strains are: staphylococcus aureus [ CMCC (B)26003], Escherichia coli [ ATCC25922], Pseudomonas aeruginosa [ CMCC (B)10104], Candida albicans [ CMCC (F)98001], all from Shanghai Lu Hui technology, Inc.
3. Main reagents and equipment:
trypticase soy peptone liquid (TSB) liquid medium, Plate Count Agar (PCA) are purchased from Shanghai Teng Gu Biotech company, sterile normal saline is purchased from Jiangxi Kodao sanitary products company, and experimental water is self-made sterile pure water;
a biological safety cabinet (Haier HR40-IIA2), a vertical pressure steam sterilizer (Shenan LDZX-30KBS), a full-temperature oscillation incubator (Huarui HZQ-F160), a table turbidimeter (object light WGZ-1000) and a table constant-temperature shaking table (Baidian ZLWY-100D).
4. Experimental methods
4.1 determination of minimum inhibitory concentration and minimum bactericidal concentration of chlorhexidine acetate physiological saline solution
Taking 4 types of common nosocomial infectious bacteria as tested strains: staphylococcus aureus (gram-positive representative), escherichia coli (gram-negative representative), pseudomonas aeruginosa (pseudomonad representative), candida albicans (fungal representative). The Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of the chlorhexidine acetate normal saline solution to the 4 types of common nosocomial infectious bacteria are determined by a two-fold dilution method.
4.1.1 determination of Minimum Inhibitory Concentration (MIC)
Taking 20 sterilized test tubes with cotton plugs, injecting 2ml of liquid culture medium into each test tube on an ultra-clean workbench, wherein 10 test tubes are used as experimental groups, and the other 10 test tubes are used as blank control groups, and each group is numbered respectively. Experimental groups: a No. 1-8 tube is prepared into a culture medium containing a certain concentration gradient chlorhexidine acetate physiological saline solution.
Experimental groups: 2ml of 2.0% chlorhexidine acetate alcoholic solution is added to 1 number pipe, takes out 2ml after the abundant mixing and adds 2 numbers pipe, takes 2ml again after the abundant mixing of 2 numbers pipe and adds 3 numbers pipe, and the class pushes to 8 numbers pipe in proper order, and the chlorhexidine acetate concentration of 1-8 numbers test tube after the dilution is respectively: 1.00%, 0.50%, 0.25%, 0.125% and so on. Add 100 μ l of working bacteria liquid containing bacterial strain into each test tube No. 1-9, No. 9 is blank bacteria-containing control (positive control) as bacteria control, observe whether bacterial colony grows normally, No. 10 is blank aseptic control (negative control), observe whether pollution.
Control group: and (4) each test tube is not added with a bacterial solution, and other operations are performed on the test tubes in the same experimental group for observation and comparison with the experimental group at the later stage. The two sets of tubes were incubated at 37 ℃ for 24 h. As a result, it was judged that the MIC of the test bacterium was determined by the lowest drug concentration at which a colony in the test tube grew aseptically (no turbidity occurred) on the premise that the No. 9 positive control tube was turbid and the No. 10 negative control tube was transparent when observed with naked eyes.
4.1.2 determination of Minimum Bactericidal Concentration (MBC)
Liquid medium of non-growing bacteria in the assay was inoculated onto solid medium plates according to the MIC assay results. That is, a sterile test tube X was visually observed in a certain bacterial laboratory group, and 100. mu.l of plating (solid medium) was aspirated from each test tube, 3 parallel plates were plated for each test tube, and the plate was marked. Culturing in 37 deg.C incubator for 24 hr. The lowest concentration of the drug in the corresponding tube grown on a sterile colony on the plate medium is taken as the MBC of the drug.
5. Determination of chlorhexidine acetate physiological saline antibacterial concentration
The Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of the chlorhexidine acetate physiological saline solution to the 4 types of common nosocomial infectious bacteria are measured, and the measurement results are detailed in Table 1.
TABLE 1
As can be seen from Table 1, when the concentration of chlorhexidine acetate in normal saline reaches 0.5% × 2-9When the concentration is g/ml, the growth and the propagation of four common nosocomial infectious bacteria can be effectively inhibited, and when the concentration of the chlorhexidine acetate normal saline reaches 0.5 percent multiplied by 2-6Can effectively kill the four common types of bacteria at g/mlNosocomial infectious bacteria;
therefore, 0.5%. times.2-9g/ml is the minimum concentration of chlorhexidine acetate normal saline, and 0.5% multiplied by 2-9g/ml～0.5％×2-6The g/ml is the optimal concentration range of the chlorhexidine acetate normal saline.
Second, the liquid spray of the present invention was subjected to a control experiment
1. Based on the minimum inhibitory concentration and the minimum bactericidal concentration of the chlorhexidine acetate normal saline solution to the 4 types of common infectious bacteria in the hospital, the minimum concentration of inhibiting the four types of bacteria is selected to be 0.5 percent multiplied by 2-9g/ml was used as the preparation concentration. Dissolving 10ml of normal saline and 0.5g of chlorhexidine acetate in a beaker, dissolving 1ml of the solution in another beaker, adding 511ml of normal saline, adding 20 g of liquid glycerol, uniformly mixing, adding a proper amount of mask interlayer material, soaking for 30 minutes, taking out with a sterile forceps, putting into a sterile operating table, opening an ultraviolet lamp for sterilization and draining, cutting after draining, and sealing in a sterile plastic bag.
2. Analysis of bacteriostatic effect of mask
Taking a common medical disposable mask as an example, 100 masks are extracted from an experimental group and a control group by a simple random sampling method, 100 volunteers in a school are randomly selected, the masks are randomly distributed to the volunteers, and the users are ordered to wear two groups of masks respectively and move for 30 minutes indoors and outdoors.
And (5) culturing and counting the soak solution of the recovered mask by adopting a colony culture counting method. The recovery mask is taken on a super clean bench, the parts with the middle length of 8cm and the width of 5cm are cut, the parts are respectively soaked in 40ml of normal saline for 30 minutes, 50 mu l of soak solution is respectively taken by a liquid transfer gun and coated on a culture dish, and bacterial colony counting is carried out after the culture is carried out for 24 hours in a constant temperature shaking table at 37 ℃.
3. Anti-fogging effect analysis
Taking 20 sterile conical flasks of 500ml, filling 300ml of sterile water of 30 ℃, placing in a full-temperature shaking incubator of 50 ℃, sealing the side by adopting materials such as preservative films, newspapers and cardboard boxes, isolating water vapor on the side, and heating in water bath. Experimental groups: 10 the mouth of the bottle is covered with a bacteriostatic and anti-fogging disposable mask; control group: the 10-bottle cap is provided with a common mask. And (3) arranging cobalt chloride test paper outside the mask, and observing and recording the time from the beginning of water bath heating to the complete color change of the cobalt chloride test paper.
4. Analysis result of bacteriostatic and anti-fogging effects of two groups of masks
The results of the colony count of the mask soak solution after the masks of the experimental group and the masks of the control group are worn and the descriptive statistics of the complete discoloration time of the cobalt chloride test paper of the two groups of masks are shown in table 2.
TABLE 2
| Maximum value | Minimum value | Standard deviation of | Mean value | |
| Experimental group colony count (one) | 172 | 27 | 72.91 | 29.934 |
| Colony count of control group | 312 | 1 | 159.95 | 52.99 |
| Experimental group color-changing time (second) | 73 | 35 | 49.43 | 2.11 |
| Control group color change time (second) | 69 | 33 | 43.26 | 2.84 |
As can be seen from Table 2, the number of colonies in the experimental group was significantly less than that in the control group when the two groups of masks were incubated with the immersion liquid and counted after wearing. The time required for complete color change of the mask test paper of the experimental group is obviously longer than that of the control group.
In t test of two independent samples of an experimental group and a control group, the Sig value of colony counting F statistic is 0.001 to 0.05, the Sig value of two sides of the t test is 0.00 to 0.05, the variances of two groups of variables have significant difference, and the difference has statistical significance; the Sig value of the statistic of the cobalt chloride discoloration time F is 0.025<0.05, the Sig value of the two sides of the t test is 0.00<0.05, the variances of the two groups of variables have obvious difference, and the difference has statistical significance. Therefore, the developed mask can be judged to have obvious bacteriostatic effect and good anti-fogging effect.
In the existing research, the antibacterial effect of the mask is enhanced mainly by changing the innovation of the original material and textile technology, and the detection of the filtering performance and the air permeability of the masks made of different fabrics and different textile technologies has certain difference from the quality inspection standard of the original masks, so that once the masks are on the market, the uniform management is difficult. The antibacterial anti-fogging mask keeps the structure and the materials of the original mask, has antibacterial and anti-fogging effects by adding medicines, and has the advantages that the filtering performance and the air permeability inspection standard are unified with those of the disposable mask, so that the market management is facilitated.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the protection scope of the present invention. All equivalent changes and modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims (7)
1. The utility model provides an anti-fogging disposable mask preparation liquid which characterized in that: comprises the following components: concentration greater than 0.5% × 2-9A g/ml physiological saline solution of chlorhexidine acetate, Chinese herbal medicine extract, liquid glycerin and aloe essential oil;
the mass ratio of the chlorhexidine acetate physiological saline solution to the Chinese herbal medicine extract is 1: 2-1: 3;
3.125g to 4g of liquid glycerin and 0.5g to 1g of aloe essential oil are added into per 100ml of the chlorhexidine acetate physiological saline solution.
2. The anti-fogging disposable mask preparation according to claim 1, wherein: the Chinese herbal medicine extract comprises wrinkled gianthyssop herb and penthorum chinense pursh, and the mass ratio of the penthorum chinense pursh to the wrinkled gianthyssop herb is 1: 1.
3. The anti-fogging disposable mask preparation according to claim 1, wherein: the concentration of the chlorhexidine acetate normal saline solution is 0.5 percent multiplied by 2-9g/ml～0.5％×2-6g/ml。
4. The anti-fogging disposable mask preparation according to claim 1, wherein: the preparation liquid is used for spraying to the center of the inner cover surface or the center of the inner core of the mask, and has antibacterial and anti-fogging effects.
5. A preparation method of anti-fogging disposable mask preparation liquid is characterized by comprising the following steps: the preparation liquid is prepared by the following steps:
s1, preparing a chlorhexidine acetate normal saline solution, and placing the chlorhexidine acetate normal saline solution in a sterile environment for use;
s2, cleaning and airing fresh penthorum chinense pursh and agastache rugosus, respectively crushing to 100-200 meshes, and uniformly mixing the raw material powder according to the mass ratio of 1:1 after crushing;
s3, adding 75% ethanol aqueous solution with the weight 10 times of that of the raw material powder into the mixed raw material powder, performing ultrasonic extraction, performing suction filtration, recovering ethanol, and concentrating to obtain a Chinese herbal medicine extract;
s4, mixing the chlorhexidine acetate normal saline solution with the Chinese herbal medicine extract according to the mass ratio of 1: 2-1: 3 to obtain a mixed solution;
s5, adding 3.125g to 4g of liquid glycerol and 0.5g to 1g of aloe essential oil into each 100ml of mixed solution, uniformly mixing by using a shaker, sterilizing for 20 to 25min by using high-pressure steam at the temperature of 121 to 130 ℃, and then filling into an aseptic spray container.
6. The method for preparing the anti-fogging disposable mask preparation according to claim 5, wherein: the preparation method of the chlorhexidine acetate normal saline solution in the S1 comprises the following steps:
s01, taking 100ml of sterile normal saline on a super clean bench, and dissolving 0.5g of chlorhexidine acetate in a beaker;
s02, placing 1ml of the solution in another beaker, adding less than 511ml of normal saline, and stirring to obtain appropriate amount of solution with concentration of more than 0.5% x 2-9And g/ml of chlorhexidine acetate normal saline solution is placed in a sterile environment for later use.
7. The method for preparing the anti-fogging disposable mask preparation according to claim 5, wherein: the ultrasonic power in S3 is set to 375W, and the extraction is carried out for 30min under the environment with the temperature of 55 ℃.
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Cited By (1)
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Application publication date: 20200529 |