CN106362195A - Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof - Google Patents
Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof Download PDFInfo
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- CN106362195A CN106362195A CN201611066201.7A CN201611066201A CN106362195A CN 106362195 A CN106362195 A CN 106362195A CN 201611066201 A CN201611066201 A CN 201611066201A CN 106362195 A CN106362195 A CN 106362195A
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- silver
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention discloses silver-carrying antibacterial hydrocolloid dressing and a preparation method thereof. The silver-carrying antibacterial hydrocolloid dressing is sequentially provided with a backing, a hydrocolloid functional dressing core and an isolation layer from top to bottom; the hydrocolloid functional dressing core is prepared from the following raw materials including sodium carboxymethylcellulose, an SIS thermoplastic elastomer, liquid paraffin, tackifying resin, an antioxidant, dioctyl adipate as a plasticizer, a bacteriostatic agent and a collaborative bacteriostatic agent. In a preparation process, the silver ion bacteriostatic agent and the plant extract collaborative bacteriostatic agent are added; with addition of the plant extract collaborative bacteriostatic agent, the addition concentration of the silver ion bacteriostatic agent is lowered when the antibacterial activity of the dressing is effectively improved; with addition of the silver ion bacteriostatic agent, the antibacterial wide adaptability and the antibacterial durability are both improved; and as the two bacteriostatic agents are used in a matching manner, a wound can be effectively prevented from being infected, and the silver-carrying antibacterial hydrocolloid dressing also has the advantages of blocking bacteria, absorbing exudate, avoiding wound adhesion, supplying an ideal wet healing environment for a wound, promoting healing of the wound and reducing formation of scars.
Description
Technical field
The invention belongs to medical dressing field, particularly to a kind of load silver bacteriostatic hydrocolloid dressing and its preparation side
Method.
Background technology
Human body skin can lead to wound because of various external force factors, thus losing natural defencive function, causes other concurrent
Disease.Traditional gauze dressing, is mainly made up through deep processing of cotton, numb material raw material, processing technology is simple, price is low
Honest and clean, easy to use.But, normal gauze dressing is unable to maintain that the moist environment needed for wound healing, and easy adhesion wound group
Knit, during dressing, cause secondary mechanical to damage.Additionally, traditional dressing does not have antibiotic property yet, wound surface is vulnerable to bacterium infection, produces
Niff simultaneously causes wound complication, is unfavorable for wound healing.With the progress of modern science and technology, Medical dressing is continuous
Occur, new clinical efficacy is also improving constantly.
Bearing hydrocolloid dressing, as a kind of emerging functional dressings, can form physical barriers in wound surface, stops outer
Boundary's moisture, dust, antibacterial etc. enter wound, it is to avoid wound superinfection, and absorb adhesion wound after sepage, being capable of wound
Preferable temperature humidity and ph environment are provided, provide a moistening closed environment for wound, absorb transudate and poison in wound
Property material, provide preferable healing environment for wound, promote the recovery from illness of wound comprehensively, the wound " wet method generally acknowledged with current authority
Therapy " theory matches.
Chinese patent cn101987207 discloses a kind of glue wound surface dressing soluble colloid and preparation method thereof, by water solublity
Macromolecule has been prepared into the processing of rubber viscous material mixing and has been applied to the wound arriving medium transudate less, can effectively play debridement
Effect, toughness, can highly airtight wound surface.
Chinese patent cn102302798go discloses a kind of preparation method of bearing hydrocolloid dressing, and this bearing hydrocolloid dressing is to wound
Mouth sepage has good absorbability, and has good elasticity and autohension.
Although existing patent in terms of bearing hydrocolloid dressing, due to staphylococcus aureuses, candidiasises and large intestine
The pathogen such as bacillus are easily bred on wound, lead to the wound infecting to be difficult to heal, and development can protect wound surface, and energy is antibacterial again
Bearing hydrocolloid dressing become clinical demand, but the patent with regard to bacteriostatic hydrocolloid few at present.
Chinese patent cn102218155a discloses a kind of preparation method of nano-silver functional hydrocolloid medical dressing, should
Nanometer silver is added in hydrocolloid patent, gives hydrocolloid lasting antibacterial functions, wound healing.However, with receiving
Rice material widely studied, there are some researches show, the contact of silver nano-grain may lead to inflammatory reaction, oxidative stress, heredity poison
Property (sexual cell is had an impact) and cytotoxicity.In view of produce after in the silver-colored particulate migration entrance human body of nano-scale is negative
Face biological effect and untoward reaction be not still distinct, and the application clinically of the bearing hydrocolloid dressing of class containing nanometer silver is extremely restricted.
Chinese patent cn104225663b discloses a kind of antibacterial bearing hydrocolloid dressing and preparation method thereof, by adding poly- six
Methylene guanidine, poly (hexamethylene) hydrochloride or hexamethylene are as antibacterial, wound healing.Although
This antibacterial bacteriostasis property is strong, and safety is good, is a kind of excellent antibacterial material that can be used for infective wound surface, but
This one-tenth belongs to cationic antibacterial, therefore can not use with the antibacterial of anionic or additive compatibility, otherwise can significantly drop
Its bactericidal activity low, this just greatly limit the range of choice of other auxiliary agents of hydrocolloid.
To sum up, need develop one kind both had well anti-water resistance bacterium, can absorbing wound exudate and toxicant, maintain
Wound wet union environment, adhesion wound, there is preferable bacteriostasis property and lasting fungistatic effect again, and safe and non-stimulating, right
Formula composition limits less bearing hydrocolloid dressing, to meet the different demands of clinical complexity wound.
Content of the invention
The present invention seeks to providing a kind of antibacterial bearing hydrocolloid dressing and its preparation side for above-mentioned the deficiencies in the prior art
Method, the bearing hydrocolloid dressing prepared by the method has good anti-microbial property, and no security risk；In preparation process add silver from
Sub- antibacterial and plant extract work in coordination with antibacterial, and the addition that plant extract works in coordination with antibacterial is effectively increased dressing bacteriostasis property
While, reduce the addition concentration of silver ion antibacterial；The addition of silver ion antibacterial had both increased antibacterial broad spectrum activity, increased suppression again
Bacterium persistency, two kinds of antibacterial use cooperatively, and can effectively prevent wound infection.Additionally, the bearing hydrocolloid dressing of present invention preparation is also
There is resistance bacterium, absorb sepage, adhesion wound, provide preferable Moist healing environment for wound, promote wound healing, reduce scar
The advantage that trace is formed.
For solving above-mentioned technical problem, the technical solution adopted in the present invention is: a kind of load silver bacteriostatic hydrocolloid dressing, its
It is characterised by: described bearing hydrocolloid dressing is followed successively by backing from lower floor to upper strata, glue body function applies core, sealing coat；Described glue
What body function applied core is to be prepared from by the raw material of following ratio of weight and number: sodium carboxymethyl cellulose 20-50 part, sis thermoplasticity
Elastomer 5-40 part, liquid paraffin 5-25 part, tackifying resin 5-20 part, antioxidant bht0.01-5 part, plasticizer adipic acid two
Monooctyl ester 1-10 part, antibacterial 0.001-5 part, collaborative antibacterial 0-10 part.
Described tackifying resin take from polyisobutylene, Petropols, rosin glyceride, gum rosin, in two terpene polymers
Any one or two or more compositionss.
Described antibacterial takes from silver chloride, silver sulfate, calcium phosphate silver, silver sulfadiazine, zirconium phosphate load silver, sodium zirconium phosphate
Any one in chlorine silver, TiO 2 carrying silver, zeomic silver ion antimicrobial agent or two or more compositionss.
Described collaborative antibacterial is the mixture of Semen Crataegi extract and Cortex Moutan extract, and its proportioning is 7:3.
Described backing is water-proof polyurethane thin film.
A kind of method preparing bacteriostatic hydrocolloid dressing as silver-colored in above-mentioned load, the method comprising the steps of:
1) stand-by as a component after sodium carboxymethyl cellulose and Ag-containing compound micronizing being sufficiently mixed uniformly；
2), by sis thermoplastic elastomer (TPE), liquid paraffin, tackifying resin, antioxidant bht, plasticizer dioctyl adipate successively
Add in kneader, under conditions of 150 DEG C, 45r/min, 30min is so as to mix homogeneously is as b component for mixing；3), by group
A is divided to be added in kneader b component, at 120 DEG C, under conditions of 45r/min, stirring 30min is so as to mix homogeneously is as c group
Point；
4), collaborative antibacterial Semen Crataegi extract and Cortex Moutan extract are added in c component, at 100 DEG C, 45r/min's
Under the conditions of stir 10min；
5), the material of mix homogeneously is uniformly applied on sealing coat, its coating thickness is 0.2 mm -2mm, and covers polyurethane
Backing, makes finished product through irradiation sterilization.
Antibacterial bearing hydrocolloid dressing prepared by the present invention, compared with prior art has the advantages that one, in glue
In body, it is loaded with antipathogenic composition, and add silver ion antibacterial and plant extract to work in coordination with antibacterial, plant in preparation process
While the addition of the collaborative antibacterial of extract is effectively increased dressing bacteriostasis property, reduce the addition concentration of silver ion antibacterial,
Reduce the biological safety risk of product；The addition of silver ion antibacterial had both increased antibacterial broad spectrum activity, increased antibacterial persistency again,
Two kinds of antibacterial use cooperatively, and product bacteriostasis rate is more than 50%, and antibacterial effectiveness is up to 7 days, can effectively prevent wound infection.2nd,
Plant bacteriostatic agent Semen Crataegi extract includes the various sterilization factors such as flavone, plant organic acid, can kill Staphylococcus aureus
Bacterium, escherichia coli, Candida albicans and Neisseria gonorrheae, to skin pruritus, tinea pedis, decubital ulcer, seborrheic dermatitis, condyloma acuminatum
There is extremely strong killing action Deng pathogenic microorganism, and to normally mucocutaneous nontoxic, non-stimulated, can effectively tie up in sterilization simultaneously
Sheath skin colony balance, improves skin resistance.Its addition makes hydrocolloid prepared by the present invention expand application, not only can
For impaired wound repair, chronic infection wound surface such as ulcer, pressure ulcer, diabetic foot ulcer, acute superficial burnses, skin abrasion,
Skin donor site, postoperative wound, and lead to the wound of delayed union because of the serious field planting of antibacterial, or suspect the wound that there is risk of infection
Mouthful, it may also be used for as the dermatosiss such as candidiasiss, tinea unguium position at skin pruritus.3rd, antibacterial effective one-tenth of Cortex Moutan extracting solution
Part is paeonol and gallic acid, to bacillus subtilis, escherichia coli, Bacillus typhi, Salmonella paratyphi, Bacillus proteuss, green pus bar
Bacterium, staphylococcuses, Hemolytic streptococcuss, streptococcus pneumoniae, vibrio cholera etc. all have stronger antibacterial action, to dysentery bacterium, green
Pus bacillus and staphylococcus aureuses have notable antibacterial action.Additionally, also have in Cortex Moutan extract calmness, heat clearing away, analgesia,
Antiinflammatory, the active component of hemostasis, have calmness, sterilization, antiinflammatory, the effect of hemostasis.4th, the present invention bearing hydrocolloid dressing safety,
Non-stimulated, physical barriers can be formed in wound surface, stop outside moisture, dust, antibacterial etc. from entering wound, reduce wound
The risk of mouth superinfection, additionally it is possible to absorb sepage, forms gel in wound surface, can also be wound while adhesion wound
Preferable temperature, humidity and ph environment are provided, absorb transudate and toxicant in wound, provide, for wound, the ring that preferably heals
Border, promotes the healing of wound comprehensively, reduces the formation of cicatrix.
Brief description
Fig. 1 carries the structural representation of silver-colored bacteriostatic hydrocolloid dressing for the present invention.
Specific embodiment
For making the object, technical solutions and advantages of the present invention clearer, technical scheme will be carried out below
Clear, complete description.
In FIG, the present invention is a kind of silver-colored bacteriostatic hydrocolloid dressing of load, and it applies core 2, isolation by backing 1, glue body function
Layer 3 composition, glue body function apply core 2 be located between backing 1 and sealing coat 3, described glue body function apply core main component and
Weight is than for sodium carboxymethyl cellulose 20-50 part, sis thermoplastic elastomer (TPE) (5-40 part), liquid paraffin 5-25 part, tackifying resin
5-20 part, antioxidant bht (0.01-5 part), plasticizer dioctyl adipate (1-10 part), antibacterial 0.001-5 part, work in coordination with
Antibacterial 0-10 part.Described tackifying resin is polyisobutylene, Petropols, rosin glyceride, gum rosin, two terpene polymers
One or more of, preferably one or more of polyisobutylene, Petropols, rosin glyceride, described antibacterial is
Ag-containing compound, carries silver, sodium zirconium phosphate chlorine silver, dioxy including silver chloride, silver sulfate, calcium phosphate silver, silver sulfadiazine, zirconium phosphate
Change titanium and carry one or more of silver, zeomic silver ion antimicrobial agent, preferably silver sulfadiazine, zirconium phosphate carries silver, sodium zirconium phosphate
One or more of chlorine silver, TiO 2 carrying silver, zeomic silver ion antimicrobial agent, described collaborative antibacterial carries for Semen Crataegi
Take thing and Cortex Moutan extract, its proportioning is 7:3, described backing is water-proof polyurethane thin film.
The invention also discloses a kind of preparation method carrying silver-colored bacteriostatic hydrocolloid dressing, it mainly comprises the steps of, one,
It is stand-by as a component after sodium carboxymethyl cellulose and Ag-containing compound micronizing are sufficiently mixed uniformly；2nd, by sis thermoplastic
Property elastomer, liquid paraffin, tackifying resin, antioxidant bht, plasticizer dioctyl adipate sequentially add in kneader,
150 DEG C, under conditions of 45r/min, 30min is so as to mix homogeneously is as b component for mixing；3rd, component a is added to kneader b
In component, at 120 DEG C, under conditions of 45r/min, stirring 30min is so as to mix homogeneously is as c component；4th, by collaborative antibacterial
Semen Crataegi extract and Cortex Moutan extract are added in c component, at 100 DEG C, stir 10min under conditions of 45r/min；5th,
The material of mix homogeneously is uniformly applied on sealing coat 3, and covers Polyurethane backings 1, make finished product through irradiation sterilization.Make
Used time removes sealing coat 3, by glue body function apply core 2 be pasted on wound, backing 1 ingress of air, can stop outside moisture,
Dust, antibacterial etc. enter wound, reduce the risk of wound superinfection, and can allow for air and vapor passes through
Embodiment 1.
First, as a component after 20 parts of sodium carboxymethyl cellulose and 0.001 part of micronizing of Ag-containing compound being sufficiently mixed uniformly
Stand-by；2nd, by sis thermoplastic elastomer (TPE) (40 parts), 25 parts of liquid paraffin, 5 parts of tackifying resin, antioxidant bht5 part, plasticising
10 parts of agent dioctyl adipate sequentially adds in kneader under conditions of 150 DEG C, 45r/min, mixes 30min, will mix all
Even material is as b component；3rd, component a is added in kneader, at 120 DEG C, under conditions of 45r/min, stirs 30min,
Make its mix homogeneously as c component；4th, by collaborative antibacterial Semen Crataegi extract 7 parts be added to c with 3 parts of Cortex Moutan extract
In component, at 100 DEG C, under conditions of 45r/min, stir 10min；5th, the material of mix homogeneously is uniformly applied on sealing coat 3,
And cover Polyurethane backings 1, make finished product through co60 irradiation sterilization.Remove sealing coat 3 during use, glue body function is applied
Core 2 is pasted on wound, backing 1 ingress of air.
Embodiment 2.
First, treat as a component after 35 parts of sodium carboxymethyl cellulose and 0.5 part of micronizing of Ag-containing compound being sufficiently mixed uniformly
With；2nd, by sis thermoplastic elastomer (TPE) (25 parts), 15 parts of liquid paraffin, 10 parts of tackifying resin, antioxidant bht2.5 part, plasticising
5 parts of agent dioctyl adipate sequentially adds in kneader under conditions of 150 DEG C, 45r/min, mixes 30min, by mix homogeneously
Material as b component；3rd, component a is added in kneader, at 120 DEG C, stirs 30min under conditions of 45r/min, make
Its mix homogeneously is as c component；4th, 5.6 parts of collaborative antibacterial Semen Crataegi extract is added to for 2.4 parts with Cortex Moutan extract
In c component, at 100 DEG C, under conditions of 45r/min, stir 10min；5th, the material of mix homogeneously is uniformly applied to sealing coat 3
On, and cover Polyurethane backings 1, make finished product through co60 irradiation sterilization.Sealing coat 3 is removed, by hydrocolloid work(during use
Core 2 can be applied and be pasted on wound, backing 1 ingress of air.
Embodiment 3.
First, treat as a component after 50 parts of sodium carboxymethyl cellulose and 5 parts of micronizing of Ag-containing compound being sufficiently mixed uniformly
With；2nd, by sis thermoplastic elastomer (TPE) (5 parts), 5 parts of liquid paraffin, 20 parts of tackifying resin, antioxidant bht0.01 part, plasticising
1 part of agent dioctyl adipate sequentially adds in kneader under conditions of 150 DEG C, 45r/min, mixes 30min, by mix homogeneously
Material as b component；3rd, component a is added in kneader, at 120 DEG C, stirs 30min under conditions of 45r/min, make
Its mix homogeneously is as c component；4th, by 0.07 part of collaborative antibacterial Semen Crataegi extract and 0.03 part of addition of Cortex Moutan extract
To in c component, at 100 DEG C, under conditions of 45r/min, stir 10min；5th, the material of mix homogeneously is uniformly applied to sealing coat 3
On, and cover Polyurethane backings 1, make finished product through co60 irradiation sterilization.Sealing coat 3 is removed, by hydrocolloid work(during use
Core 2 can be applied and be pasted on wound, backing 1 ingress of air.
Embodiment 4.
First, treat as a component after 20 parts of sodium carboxymethyl cellulose and 5 parts of micronizing of Ag-containing compound being sufficiently mixed uniformly
With；2nd, by sis thermoplastic elastomer (TPE) (40 parts), 25 parts of liquid paraffin, 5 parts of tackifying resin, antioxidant bht5 part, plasticizer
10 parts of dioctyl adipate sequentially adds in kneader under conditions of 150 DEG C, 45r/min, mixes 30min, by mix homogeneously
Material as b component；3rd, component a is added in kneader, at 120 DEG C, stirs 30min under conditions of 45r/min, make
Its mix homogeneously is as c component；4th, by 0.07 part of collaborative antibacterial Semen Crataegi extract and 0.03 part of addition of Cortex Moutan extract
To in c component, at 100 DEG C, under conditions of 45r/min, stir 10min；5th, the material of mix homogeneously is uniformly applied to sealing coat 3
On, and cover Polyurethane backings 1, make finished product through co60 irradiation sterilization.Sealing coat 3 is removed, by hydrocolloid work(during use
Core 2 can be applied and be pasted on wound, backing 1 ingress of air.
Embodiment 5.
First, as a component after 20 parts of sodium carboxymethyl cellulose and 0.05 part of micronizing of Ag-containing compound being sufficiently mixed uniformly
Stand-by；2nd, by sis thermoplastic elastomer (TPE) (40 parts), 25 parts of liquid paraffin, 5 parts of tackifying resin, antioxidant bht5 part, plasticising
10 parts of agent dioctyl adipate sequentially adds in kneader under conditions of 150 DEG C, 45r/min, mixes 30min, will mix all
Even material is as b component；3rd, component a is added in kneader, at 120 DEG C, under conditions of 45r/min, stirs 30min,
Make its mix homogeneously as c component；4th, by 1.4 parts of collaborative antibacterial Semen Crataegi extract and 0.6 part of addition of Cortex Moutan extract
To in c component, at 100 DEG C, under conditions of 45r/min, stir 10min；5th, the material of mix homogeneously is uniformly applied to sealing coat 3
On, and cover Polyurethane backings 1, make finished product through co60 irradiation sterilization.Sealing coat 3 is removed, by hydrocolloid work(during use
Core 2 can be applied and be pasted on wound, backing 1 ingress of air.
Embodiment 6.
First, treat as a component after 20 parts of sodium carboxymethyl cellulose and 0.5 part of micronizing of Ag-containing compound being sufficiently mixed uniformly
With；2nd, by sis thermoplastic elastomer (TPE) (40 parts), 25 parts of liquid paraffin, 5 parts of tackifying resin, antioxidant bht5 part, plasticizer
10 parts of dioctyl adipate sequentially adds in kneader under conditions of 150 DEG C, 45r/min, mixes 30min, by mix homogeneously
Material as b component；3rd, component a is added in kneader, at 120 DEG C, stirs 30min under conditions of 45r/min, make
Its mix homogeneously is as c component；4th, 2.1 parts of collaborative antibacterial Semen Crataegi extract is added to for 0.9 part with Cortex Moutan extract
In c component, at 100 DEG C, under conditions of 45r/min, stir 10min；5th, the material of mix homogeneously is uniformly applied to sealing coat 3
On, and cover Polyurethane backings 1, make finished product through co60 irradiation sterilization.Sealing coat 3 is removed, by hydrocolloid work(during use
Core 2 can be applied and be pasted on wound, backing 1 ingress of air.
Embodiment 7.
First, treat as a component after 20 parts of sodium carboxymethyl cellulose and 1.0 parts of micronizing of Ag-containing compound being sufficiently mixed uniformly
With；2nd, by sis thermoplastic elastomer (TPE) (40 parts), 25 parts of liquid paraffin, 5 parts of tackifying resin, antioxidant bht5 part, plasticizer
10 parts of dioctyl adipate sequentially adds in kneader under conditions of 150 DEG C, 45r/min, mixes 30min, by mix homogeneously
Material as b component；3rd, component a is added in kneader, at 120 DEG C, stirs 30min under conditions of 45r/min, make
Its mix homogeneously is as c component；4th, 0.7 part of collaborative antibacterial Semen Crataegi extract is added to for 0.3 part with Cortex Moutan extract
In c component, at 100 DEG C, under conditions of 45r/min, stir 10min；5th, the material of mix homogeneously is uniformly applied to sealing coat 3
On, and cover Polyurethane backings 1, make finished product through co60 irradiation sterilization.Sealing coat 3 is removed, by hydrocolloid work(during use
Core 2 can be applied and be pasted on wound, backing 1 ingress of air.
The bacteriostasis rate of the silver-colored antibacterial dressing of load that above-described embodiment is obtained and antibacterial effect duration are determined, its bacteriostasis rate
See table with antibacterial effect duration.
Table 1
| Dressing species | Bacteriostasis rate | Antibacterial effect duration (my god) |
| Embodiment 1 | 100% | 2 |
| Embodiment 2 | 100% | 7 |
| Embodiment 3 | 100% | 7 |
| Embodiment 4 | 100% | 7 |
| Embodiment 5 | 80% | 4 |
| Embodiment 6 | 100% | 7 |
| Embodiment 7 | 100% | 7 |
Claims (6)
1. a kind of carry silver-colored bacteriostatic hydrocolloid dressing it is characterised in that: described bearing hydrocolloid dressing is followed successively by backing from lower floor to upper strata
(1), glue body function applies core (2), sealing coat (3)；What described glue body function applied core is by the raw material of following ratio of weight and number
It is prepared from: sodium carboxymethyl cellulose 20-50 part, sis thermoplastic elastomer (TPE) 5-40 part, liquid paraffin 5-25 part, tackifying resin
5-20 part, antioxidant bht0.01-5 part, plasticizer dioctyl adipate 1-10 part, antibacterial 0.001-5 part, work in coordination with antibacterial
Agent 0-10 part.
2. according to claim 1 carry silver-colored bacteriostatic hydrocolloid dressing it is characterised in that: described tackifying resin is taken from poly- different
Any one in butylene, Petropols, rosin glyceride, gum rosin, two terpene polymers or two or more compositionss.
3. according to claim 1 carry silver-colored bacteriostatic hydrocolloid dressing it is characterised in that: described antibacterial takes from chlorination
Silver, silver sulfate, calcium phosphate silver, silver sulfadiazine, zirconium phosphate carry silver, sodium zirconium phosphate chlorine silver, TiO 2 carrying silver, zeomic silver from
Any one in sub- antibacterial or two or more compositionss.
4. according to claim 1 carry silver-colored bacteriostatic hydrocolloid dressing it is characterised in that: described collaborative antibacterial is Fructus Crataegi
Nuclear extract and the mixture of Cortex Moutan extract, its quality proportioning is 7:3.
5. according to claim 1 carry silver-colored bacteriostatic hydrocolloid dressing it is characterised in that: described backing is water-proof polyurethane
Thin film.
6. a kind of prepare the as claimed in claim 1 method carrying silver-colored bacteriostatic hydrocolloid dressing it is characterised in that: methods described includes
Following steps:
1) stand-by as a component after sodium carboxymethyl cellulose and Ag-containing compound micronizing being sufficiently mixed uniformly；
2), by sis thermoplastic elastomer (TPE), liquid paraffin, tackifying resin, antioxidant bht, plasticizer dioctyl adipate successively
Add in kneader, under conditions of 150 DEG C, 45r/min, 30min is so as to mix homogeneously is as b component for mixing；3), by group
A is divided to be added in kneader b component, at 120 DEG C, under conditions of 45r/min, stirring 30min is so as to mix homogeneously is as c group
Point；
4), collaborative antibacterial Semen Crataegi extract and Cortex Moutan extract are added in c component, at 100 DEG C, 45r/min's
Under the conditions of stir 10min；
5), the material of mix homogeneously is uniformly applied on sealing coat, its coating thickness is 0.2 mm -2mm, and covers polyurethane
Backing, makes finished product through irradiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611066201.7A CN106362195A (en) | 2016-11-28 | 2016-11-28 | Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611066201.7A CN106362195A (en) | 2016-11-28 | 2016-11-28 | Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN106362195A true CN106362195A (en) | 2017-02-01 |
Family
ID=57891003
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| CN201611066201.7A Pending CN106362195A (en) | 2016-11-28 | 2016-11-28 | Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof |
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| CN109276748A (en) * | 2018-11-28 | 2019-01-29 | 广州润虹医药科技股份有限公司 | One kind prevents adhesion promoting healing antibacterial bearing hydrocolloid dressing and preparation method thereof |
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| CN111643718A (en) * | 2020-06-12 | 2020-09-11 | 扬州百思泰医疗科技有限公司 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
| CN112500592A (en) * | 2020-11-04 | 2021-03-16 | 浙江崇山生物制品有限公司 | Production method of radiotherapy compensation film with antibacterial function |
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| CN111643718A (en) * | 2020-06-12 | 2020-09-11 | 扬州百思泰医疗科技有限公司 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
| CN112500592A (en) * | 2020-11-04 | 2021-03-16 | 浙江崇山生物制品有限公司 | Production method of radiotherapy compensation film with antibacterial function |
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Application publication date: 20170201 |