CN114225093A - Antibacterial dressing with composite function and preparation method thereof - Google Patents
Antibacterial dressing with composite function and preparation method thereof Download PDFInfo
- Publication number
- CN114225093A CN114225093A CN202111583751.7A CN202111583751A CN114225093A CN 114225093 A CN114225093 A CN 114225093A CN 202111583751 A CN202111583751 A CN 202111583751A CN 114225093 A CN114225093 A CN 114225093A
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- China
- Prior art keywords
- layer
- antibacterial
- dressing
- gel
- adsorption
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Images
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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- A61F13/00051—Accessories for dressings
- A61F13/00072—Packaging of dressings
- A61F13/00076—Packaging of adhesive dressings
- A61F13/0008—Packaging of adhesive dressings having means for facilitating the removal of the packaging and release liner
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0286—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of non adhesive dressings
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses an antibacterial dressing with a composite function and a preparation method thereof, the antibacterial dressing has a four-layer structure, the first layer is a gel layer (with a moisturizing effect and is in direct contact with a wound), the second layer is an antibacterial layer (antibacterial layers with different liquid absorption amounts can be selected to be combined according to different exudate conditions of the wound, the antibacterial layers comprise a gauze antibacterial layer, a non-woven fabric antibacterial layer and a polyurethane foam antibacterial layer and can be replaced), the third layer is an adsorption layer (can be replaced), and the fourth layer is a back lining layer. The antibacterial dressing only plays a role in infected wounds, does not damage and interfere fragile skin flora around the infected wounds, can be used alternatively, and selects antibacterial layers with different liquid absorption functions according to the liquid seepage amount of a patient.
Description
Technical Field
The invention belongs to the field of medical dressings, relates to an antibacterial dressing, and particularly relates to an antibacterial dressing with a composite function and a preparation method thereof.
Background
Wounds are the damages to the integrity of the skin, and microorganisms invade the skin when still in opportunity and grow in the wounds, and finally cause wound infection along with the mass propagation of the microorganisms, and the wounds are generally divided into acute infection wounds and chronic infection wounds.
The acute infection wound is mainly characterized by local red, swelling, heat, pain, dysfunction and general symptoms which depend on the infection degree and the constitution. Including pyogenic wound infection (often seen in wound cellulitis, wound suppuration, etc.) and specific wound infection (tetanus, tuberculosis, anaerobic gangrene, etc.).
The symptoms of chronic wound infection are mainly manifested by red swelling, induration, warmth, pain or tenderness around the wound, poor granulation tissue formation, dysesthesia, fragile tissue, suppuration or increased wound secretion, infiltration, edema.
Both acutely infected wounds and chronically infected wounds secrete large amounts of toxins, concentrates, necrotic tissue, etc., thus slowing the rate of healing of the wound.
The medical antibacterial dressing is a wound dressing with antibacterial effect, can cover the surface of damaged skin to play a temporary barrier role, provides antibacterial protection for the damaged skin, prevents wound infection and further promotes wound healing.
An ideal dressing should have the following conditions: (1) can stop bleeding within a few hours; (2) has certain adhesion to tissues; (3) can be easily used; (4) dissolution can be easily controlled during wound debridement.
At present, medical dressings at home and abroad are mainly ordinary absorbent sterile gauze and only have wound protection and no treatment function. With the development of science and technology and the improvement of living standard, various medical dressings with treatment function are rapidly increased, wherein the medical dressings mainly have the functions of resisting bacteria, promoting healing, preserving moisture and reducing pain. For example, silver ion dressing 'wet silver' of the company Baehmann Germany, silver ion sponge dressing of the company Youtou French and hydrocolloid moisturizing dressing are all the international famous functional dressing brands. In the last decade, functional dressings based on nano-silver and alginate have also developed rapidly. However, medical dressing products with long-acting antibacterial effect and composite functions of moisture retention, adsorption and the like are not reported.
The existing antibacterial medical dressing mainly depends on the antibacterial agent contained on the dressing to sterilize and disinfect the wound. At present, the silver-containing dressing widely applied in the medical field is imported, such as Youge, Mei Pi kang, De Hui silver and the like.
The main defects are as follows: (1) the long-term use of the silver ion dressing can cause the pigmentation of the skin around the wound and the phenomenon of skin blackening. (2) Different silver ion dressings have different types and contents of silver such as silver sulfadiazine, nano silver, silver sulfate and the like, and different silver ions have different toxicity, so that certain damage can be caused to the body after long-term use. (3) Clinically, most infected wounds can generate peculiar smell, and the silver-containing dressing only has an antibacterial effect and does not pay much attention to peculiar smell removal. (4) When the wound surface of an infected wound is cleaned, the wound new tissue can be damaged; (5) frequent dressing change greatly increases the workload of medical workers and brings inconvenience to patients.
Disclosure of Invention
The invention aims to solve the problem that fragile skin around an infected wound is damaged, and the existing antibacterial medical dressing has the defects that a large number of silver ions cause harm to body health, the development speed of the infected wound is high, the infected wound is easy to deteriorate, bad smell is easy to generate, the workload of medical workers is heavy, and pain of a patient is difficult to endure when the dressing is replaced. Large-particle-size silver ions, broad spectrum sterilization. Effectively killing pathogenic bacteria (escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa) and multiple drug-resistant bacteria (methicillin-resistant staphylococcus aureus and vancomycin-resistant enterococcus).
The invention also provides a preparation method of the antibacterial dressing.
In order to achieve the purpose, the invention adopts the following technical scheme:
an antimicrobial dressing having a composite function comprising: a gel layer for contacting a wound; the antibacterial layer is detachably arranged on the gel layer; the adsorption layer is detachably arranged on the antibacterial layer; the back lining layer is detachably arranged on the adsorption layer;
the antibacterial layer and the adsorption layer have the same area, and the area of the gel layer is smaller than that of the antibacterial layer.
In the invention, the antibacterial dressing has a four-layer structure, wherein the first layer is a gel layer (which has a moisturizing effect and is in direct contact with a wound), the second layer is an antibacterial layer (which can be combined by selecting antibacterial layers with different liquid absorption amounts according to different exudate conditions of the wound, the antibacterial layer comprises a gauze antibacterial layer, a non-woven fabric antibacterial layer and a polyurethane foam antibacterial layer and can be replaced), the third layer is an adsorption layer (which can be replaced), and the fourth layer is a back lining layer.
When the antibacterial dressing is used, the dressing is taken out, medical staff assembles the gel layer, the antibacterial layer and the adsorption layer according to the wound condition of a patient and then attaches the gel layer to an infected wound, and after the dressing is used for a certain time according to the actual condition of the patient, the adsorption layer and the antibacterial layer are taken down, and the adsorption layer and the antibacterial layer which are replaced are attached to the gel layer.
In a preferred embodiment of the present invention, the area of the gel layer is 3/4 times the area of the antibacterial layer.
In a preferred embodiment of the present invention, the surface of the gel layer is provided with a plurality of through holes.
The invention also provides a preparation method of the antibacterial dressing with the composite function, which comprises the following steps:
1) preparation of gel layer: uniformly mixing polyquaternium and a gel matrix, performing heat preservation and crosslinking to obtain a gel layer, and independently packaging;
2) preparation of the antibacterial layer: preparing an antibacterial agent into an aqueous solution, combining the aqueous solution with a carrier through a padding method to obtain an antibacterial layer, and independently packaging;
3) an adsorption layer: adhering an adsorption substance to the adsorption layer through an adhesive;
4) bonding the adsorption layer obtained in the step 3) with a back lining layer, and independently packaging;
5) sterilizing the gel layer obtained in the step 1), the antibacterial layer obtained in the step 2) and the back lining layer with the adsorption layer obtained in the step 4) to obtain the antibacterial dressing.
As a preferable scheme of the invention, in the step 1), the mass ratio of the polyquaternium to the gel matrix is 1: 4-8.
As a preferable scheme of the invention, the gel matrix comprises one or a mixture of hydroxyethyl cellulose, xanthan gum, fluorosilicone hydrogel polymer, guar gum, sodium hyaluronate and trimethyl glycine hydrate.
In a preferable embodiment of the invention, in step 2), the antibacterial agent includes one or more of zirconium phosphate-supported silver, glass-supported silver, silver nitrate and silver sulfate.
As a preferable embodiment of the present invention, the carrier in the step 2) includes gauze, non-woven fabric or polyurethane foam.
In a preferred embodiment of the present invention, the mass fraction of the antibacterial agent in the aqueous solution of the antibacterial agent is 0.05 to 0.1%.
As a preferable scheme of the invention, in the step 3), the adsorption substance is activated carbon, and the mass ratio of the activated carbon to the adhesive is 5-9: 1.
Compared with the prior art, the invention has the following beneficial effects:
1) the antibacterial dressing is used for medium-to-high infected wounds in exudates, and can effectively solve the problem of wound infection;
2) the antibacterial dressing provides a moist environment for the wound and the surrounding skin, and is more beneficial to wound healing;
3) the antibacterial dressing disclosed by the invention has no influence on intact skin around a wound, protects the microenvironment of normal skin, and plays a role in moisturizing and nourishing skin;
4) the antibacterial dressing has a broad spectrum of antibacterial effects, the raw materials are safe and nontoxic, no body injury is caused, and pathogenic bacteria (escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa) and multiple drug-resistant bacteria (methicillin-resistant staphylococcus aureus and vancomycin-resistant enterococcus) are effectively killed;
5) the antibacterial dressing is simple and convenient to operate, reduces the workload of medical workers, and brings convenience to patients.
Drawings
Fig. 1 is a schematic view of an antimicrobial dressing of the present invention.
FIG. 2 is a schematic view of a gel layer of the present invention.
In the figures, 1. backing layer; 2. an adsorption layer; 3. an antimicrobial layer; 4. a gel layer; 5. and a through hole.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 and 2, the present invention first provides an antibacterial dressing with a composite function, comprising:
a gel layer 4, the gel layer 4 for contacting a wound; the antibacterial layer 3 is detachably arranged on the gel layer 4; the adsorption layer 2 is detachably arranged on the antibacterial layer 3; the backing layer 1, the backing layer 1 is detachably arranged on the adsorption layer 2; the areas of the antibacterial layer 3 and the adsorption layer 2 are the same, the area of the gel layer 4 is 3/4 of the area of the antibacterial layer 3, and a plurality of through holes 5 are arranged on the surface of the gel layer 4.
Dense through holes are distributed on the surface of the gel layer, so that absorption of seepage is facilitated on one hand, and the antibacterial factor can contact the wound surface through the holes on the other hand; the skin around the infected wound is in a moist state under the covering of the silica gel layer, and the moist state of the skin is kept; the gel layer has good skin viscosity and can be tightly combined with the skin; the gel layer is provided with raw materials for releasing negative ions, and can release negative ions to promote wound healing.
The gel layer slowly releases the antibacterial factor under the action of the tissue fluid and reaches the wound surface through the holes on the surface of the gel layer, and the antibacterial factor can effectively control the propagation of microorganisms; the antibacterial layer is as large as the area of the adsorption layer.
The adsorption layer is a layer on the antibacterial layer, and can fully absorb the bad smell generated by infected wounds.
The back lining layer has an adhesion layer, is adhered on the adsorption layer and can effectively control the bad smell of the adsorption layer to diffuse into the environment.
In the invention, all the raw materials are commercially available, the backing layer in the invention is a backing layer commonly used in the prior art, and the carrier of the adsorption layer can be a carrier commonly used in the market for loading activated carbon.
Example 1
The embodiment provides a preparation method of an antibacterial dressing with composite functions, which comprises the following steps:
a silicone gel layer: the total content of polyquaternium, hydroxyethyl cellulose, xanthan gum, guar gum and sodium hyaluronate is 15%, and the balance is solvent. Mixing the components in a ratio of 2:3:3: 2: 1, mixing with water, dissolving, and performing heat preservation and crosslinking to obtain a gel layer.
A gauze antibacterial layer: preparing the glass silver-loaded into 0.05% aqueous solution, and combining absorbent gauze with the glass silver-loaded in a padding mode.
A non-woven fabric antibacterial layer: the glass silver-carrying is made into 0.05 percent aqueous solution, and the non-woven fabric is combined with the glass silver-carrying in a padding mode.
Polyurethane foam antibacterial layer: the glass-carried silver is prepared into a 0.05 percent aqueous solution, and the polyurethane foam is combined with the glass-carried silver in a padding mode.
An adsorption layer: mixing activated carbon and an adhesive according to the ratio of 5: 1, uniformly mixing and coating the mixture on the adsorption layer.
And bonding the back lining layer with the adsorption layer to obtain the back lining layer with the adsorption layer.
Example 2
The embodiment provides a preparation method of an antibacterial dressing with composite functions, which comprises the following steps:
gel layer: the total content of polyquaternium, hydroxymethyl cellulose, guar gum and trimethylglycine is 15 percent, and the balance is solvent. Mixing the above components with water at a ratio of 2:3:4:1, dissolving, and performing heat preservation and crosslinking to obtain a gel layer.
A gauze antibacterial layer: preparing the glass silver-loaded into 0.08% aqueous solution, and combining absorbent gauze with the glass silver-loaded by padding.
A non-woven fabric antibacterial layer: the glass silver-carrying is made into 0.08 percent aqueous solution, and the non-woven fabric is combined with the glass silver-carrying in a padding mode.
Polyurethane foam antibacterial layer: the glass-carried silver is prepared into a 0.08 percent aqueous solution, and the polyurethane foam is combined with the glass-carried silver in a padding mode.
An adsorption layer: mixing activated carbon and an adhesive according to the proportion of 7: 1, uniformly mixing and coating the mixture on the adsorption layer.
And bonding the back lining layer with the adsorption layer to obtain the back lining layer with the adsorption layer.
Example 3
The embodiment provides a preparation method of an antibacterial dressing with composite functions, which comprises the following steps:
gel layer: the total content of polyquaternium, fluorosilicone hydrogel polymer, sodium hyaluronate and trimethylglycine is 15%, and the balance is solvent. Mixing the components with water according to the ratio of 2:7:5:4, dissolving, and performing heat preservation and crosslinking to obtain a gel layer.
A gauze antibacterial layer: preparing the glass silver-loaded into 0.1% aqueous solution, and combining absorbent gauze with the glass silver-loaded in a padding mode.
A non-woven fabric antibacterial layer: the glass silver-carrying is made into 0.1 percent aqueous solution, and the non-woven fabric is combined with the glass silver-carrying in a padding mode.
Polyurethane foam antibacterial layer: the glass-carried silver is prepared into a 0.1 percent aqueous solution, and the polyurethane foam is combined with the glass-carried silver in a padding mode.
An adsorption layer: mixing activated carbon and an adhesive according to the weight ratio of 9:1, uniformly mixing and coating the mixture on the adsorption layer.
And bonding the back lining layer with the adsorption layer to obtain the back lining layer with the adsorption layer.
When the antibacterial dressing is used, the dressing is taken out, medical staff assembles the gel layer, the antibacterial layer and the adsorption layer according to the wound condition of a patient and then attaches the gel layer to an infected wound, and after the dressing is used for a certain time according to the actual condition of the patient, the adsorption layer and the antibacterial layer are taken down, and the adsorption layer and the antibacterial layer which are replaced are attached to the gel layer.
The antibacterial effects of the examples 1-3 are tested according to WS/T650-2019 'evaluation method of antibacterial and bacteriostatic effects', the effect of the example 3 is superior to that of the examples 1 and 2, and specific data are shown in tables 1 and 2;
the moisturizing effect of the examples 1-3 was tested by performing experimental operations according to the method for measuring the moisturizing ability of MAAs of gloiopeltis furcata in the literature "analysis of MAAs absorption moisturizing effect in gloiopeltis furcata" on the research and development of natural products, experimental data show that the example 3 is superior to the examples 1 and 2, and specific data are shown in table 3;
table 4, statistical results of the odor adsorption effect of examples 1-3 (statistical results of feedback after trial by 100 persons).
TABLE 1 results of the tests for antibacterial effectiveness of examples 1 to 3 (Escherichia coli, Staphylococcus aureus, Candida albicans)
TABLE 2 results of the tests for antibacterial effectiveness of examples 1 to 3 (Pseudomonas aeruginosa, vancomycin-resistant enterococcus MASA, Staphylococcus aureus-resistant VRE)
TABLE 3 Experimental data for moisturizing effect of examples 1-3
TABLE 4 qualitative experimental data for odor adsorption of examples 1-3
Therefore, the antibacterial dressing provides a moist environment for the wound and the surrounding skin, and is more beneficial to wound healing; the wound dressing has no influence on intact skin around the wound, protects the microenvironment of normal skin, and plays a role in moisturizing and nourishing the skin; the antibacterial agent has a wide antibacterial effect, is safe and nontoxic in raw materials, cannot cause any body injury, effectively kills pathogenic bacteria (escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa) and multiple drug-resistant bacteria (methicillin-resistant staphylococcus aureus and vancomycin-resistant enterococcus) and can fully absorb bad smell generated by infected wounds.
While the invention has been described with respect to a preferred embodiment, it will be understood by those skilled in the art that the foregoing and other changes, omissions and deviations in the form and detail thereof may be made without departing from the scope of this invention. Those skilled in the art can make various changes, modifications and equivalent arrangements, which are equivalent to the embodiments of the present invention, without departing from the spirit and scope of the present invention, and which may be made by utilizing the techniques disclosed above; meanwhile, any changes, modifications and variations of the above-described embodiments, which are equivalent to those of the technical spirit of the present invention, are within the scope of the technical solution of the present invention.
Claims (10)
1. An antimicrobial dressing having a composite function, comprising:
a gel layer for contacting a wound;
the antibacterial layer is detachably arranged on the gel layer;
the adsorption layer is detachably arranged on the antibacterial layer;
the back lining layer is detachably arranged on the adsorption layer;
the antibacterial layer and the adsorption layer have the same area, and the area of the gel layer is smaller than that of the antibacterial layer.
2. The antiseptic dressing of claim 1 wherein the area of the gel layer is 3/4 times the area of the antiseptic layer.
3. The multifunctional antiseptic dressing of claim 1 wherein the gel layer is provided with a plurality of through holes on the surface.
4. A method for preparing the antibacterial dressing with composite function according to any one of claims 1 to 3, wherein the preparation method comprises the following steps:
1) preparation of gel layer: uniformly mixing polyquaternium and a gel matrix, performing heat preservation and crosslinking to obtain a gel layer, and independently packaging;
2) preparation of the antibacterial layer: preparing an antibacterial agent into an aqueous solution, combining the aqueous solution with a carrier through a padding method to obtain an antibacterial layer, and independently packaging;
3) an adsorption layer: adhering an adsorption substance to the adsorption layer through an adhesive;
4) bonding the adsorption layer obtained in the step 3) with a back lining layer, and independently packaging;
5) sterilizing the gel layer obtained in the step 1), the antibacterial layer obtained in the step 2) and the back lining layer with the adsorption layer obtained in the step 4) to obtain the antibacterial dressing.
5. The preparation method of the antibacterial dressing with the composite function according to claim 4, wherein in the step 1), the mass ratio of the polyquaternium to the gel matrix is 1: 4-8.
6. The method for preparing the antibacterial dressing with the composite function according to claim 4 or 5, wherein the gel matrix comprises one or more of hydroxyethyl cellulose, xanthan gum, fluorosilicone hydrogel polymer, guar gum, sodium hyaluronate and trimethyl glycine hydrate.
7. The method for preparing the antibacterial dressing with compound functions according to claim 4, wherein in the step 2), the antibacterial agent comprises one or more of zirconium phosphate-loaded silver, glass-loaded silver, silver nitrate and silver sulfate.
8. The method for preparing an antibacterial dressing with compound functions as claimed in claim 4 or 7, wherein the carrier in step 2) comprises gauze, non-woven fabric or polyurethane foam.
9. The method for preparing an antibacterial dressing with compound function according to claim 8, wherein the mass fraction of the antibacterial agent in the aqueous solution of the antibacterial agent is 0.05-0.1%.
10. The preparation method of the antibacterial dressing with the composite function according to claim 4, wherein in the step 3), the adsorption substance is activated carbon, and the mass ratio of the activated carbon to the adhesive is 5-9: 1.
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| CN115300660A (en) * | 2022-08-04 | 2022-11-08 | 惠州华阳医疗器械有限公司 | Antibacterial dressing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207605066U (en) * | 2017-01-12 | 2018-07-13 | 广东泰宝医疗器械技术研究院有限公司 | A kind of medical dressing being freely disassembled combination |
| CN208193326U (en) * | 2017-05-27 | 2018-12-07 | 河南汇博医疗股份有限公司 | One kind prevents adhesion promoting healing combine dressing |
| US20210169698A1 (en) * | 2017-11-06 | 2021-06-10 | Brightwake Limited | Antimicrobial dressing |
-
2021
- 2021-12-22 CN CN202111583751.7A patent/CN114225093A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207605066U (en) * | 2017-01-12 | 2018-07-13 | 广东泰宝医疗器械技术研究院有限公司 | A kind of medical dressing being freely disassembled combination |
| CN208193326U (en) * | 2017-05-27 | 2018-12-07 | 河南汇博医疗股份有限公司 | One kind prevents adhesion promoting healing combine dressing |
| US20210169698A1 (en) * | 2017-11-06 | 2021-06-10 | Brightwake Limited | Antimicrobial dressing |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300660A (en) * | 2022-08-04 | 2022-11-08 | 惠州华阳医疗器械有限公司 | Antibacterial dressing and preparation method thereof |
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