CN114343975A - Wet wound dressing and its prepn - Google Patents
Wet wound dressing and its prepn Download PDFInfo
- Publication number
- CN114343975A CN114343975A CN202210033816.9A CN202210033816A CN114343975A CN 114343975 A CN114343975 A CN 114343975A CN 202210033816 A CN202210033816 A CN 202210033816A CN 114343975 A CN114343975 A CN 114343975A
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- CN
- China
- Prior art keywords
- layer
- wound
- dressing
- parts
- mixture
- Prior art date
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- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00059—Accessories for dressings provided with visual effects, e.g. printed or colored
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01034—Non-adhesive bandages or dressings characterised by a property
- A61F13/01038—Flexibility, stretchability or elasticity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01034—Non-adhesive bandages or dressings characterised by a property
- A61F13/01042—Absorbency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01034—Non-adhesive bandages or dressings characterised by a property
- A61F13/01046—Air-vapor permeability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
- A61F13/0243—Adhesive bandages or dressings wound covering film layers without a fluid retention layer characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Manufacturing & Machinery (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a wound surface wet dressing and a preparation method thereof, relating to the field of dressings. A wound wet dressing comprising, in order from far to near to a wound: a back lining layer, a protective layer, a dressing layer and a contact layer; the dressing layer consists of the following raw materials: sodium alginate, carboxymethyl chitosan, Arabic gum, ferulic acid, glycerol, honey, plant polysaccharide and Chinese medicinal additives. The dressing has the effects of ventilation, water resistance, moisture retention and hemostasis, and can promote wound healing and relieve pain.
Description
Technical Field
The invention relates to the field of dressings, in particular to a wound wet dressing and a preparation method thereof.
Background
People inevitably have certain physical conditions of colliding with or bruising themselves in life, and the traditional wound treatment method after the trauma is generated generally adopts a band-aid or a wound dressing. The existing products in the market also have a water absorption pad which can absorb seepage and has weak absorbability. However, the wound is also prone to drying, scabbing and cracking, is not easy to heal or is easy to scar after a long healing time, and generates a wound. If the body recovers by itself alone, the speed of wound healing and wound repair is slow and scars may be left.
The dressing which is most clinically used at present is mainly made of gauze, cotton pads and the like, is mostly made of cotton, linen and linen, belongs to an inert dressing, and has no obvious promotion effect on the healing of wound surfaces. The dressing has the advantages of low price, wide raw material sources, simple preparation, certain absorbability to wound exudate, wound protection and reusability. However, with the continuous and deep research on wound repair, the dressing has limitations due to the defects of being not beneficial to wound healing, easily causing wound infection, poor hemostatic effect and the like.
The addition of the functional antibacterial agent is an important way for improving the antibacterial performance of the novel dressing. Commonly used antibacterial agents include silver-based, iodine-based, organic small molecule antibacterial agents, antibiotics, and the like. However, silver is expensive and easily causes heavy metal residue; the stability of iodine is poor, and the irritation to skin and mucosa is strong; the organic micromolecule antibacterial agent has poor antibacterial broad spectrum and antibacterial effect; antibiotics have been increasingly limited in use in recent years.
Disclosure of Invention
The invention aims to provide a moist wound dressing which has the characteristics of quick hemostasis and strong bacteriostasis.
Another object of the present invention is to provide a method for preparing a moist wound dressing, which can be simply and efficiently prepared.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
In one aspect, embodiments of the present application provide a wound wet dressing, which sequentially includes, from far to near to a wound: a back lining layer, a protective layer, a dressing layer and a contact layer;
the dressing layer consists of the following raw materials: sodium alginate, carboxymethyl chitosan, Arabic gum, ferulic acid, glycerol, honey, plant polysaccharide and Chinese medicinal additives.
In another aspect, an embodiment of the present application provides a method for preparing a wound wet dressing, including the following steps:
modifying cellulose by adopting guanidine salt, then performing suction filtration to form a film, and covering one end of a back lining layer to form a protective layer;
performing ultrasonic treatment on sodium alginate, carboxymethyl chitosan and glycerol to obtain a mixture A, extracting thuja, purple perilla, platycodon grandiflorum and green tea with water to obtain a filtrate, heating and mixing the mixture A with Arabic gum, ferulic acid, plant polysaccharide, honey and the filtrate to obtain a mixture B, concentrating the mixture B, coating the mixture B on a protective layer, and drying to form a dressing layer;
a silicone gel, hydrogel or pectin is coated on the adjuvant layer to form a contact layer.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the dressing is divided into the back lining layer, the protective layer, the dressing layer and the contact layer, wherein the back lining layer PU film has the characteristics of good elasticity and high lightness, can adapt to joint positions, has the advantages of water resistance and air permeability, can ensure that wounds are ventilated but not infected, is transparent and visible, can be replaced according to the absorption condition of the dressing, and is more convenient. The protective layer is a cellulose membrane of the modified kettle, and has stronger stability and antibacterial property; the auxiliary material layer is crosslinked by adopting sodium alginate and carboxymethyl chitosan, a nano-scale network interpenetrating structure can be prepared, the nano-scale network interpenetrating structure has good dispersibility and stability, the drug loading is high, other components can be effectively encapsulated, the stability and the bioactivity of the whole dressing layer are improved, and then Arabic gum for promoting wound healing, ferulic acid for enhancing the blood coagulation effect, medical-grade honey for promoting wound debridement and autolysis, plant polysaccharide for promoting hemostasis and traditional Chinese medicine additives for diminishing inflammation, relieving pain and expelling pus are added; the contact layer adopts silicone gel, hydrogel or pectin, so that the wettability and the slightly acidic environment of the wound can be maintained, and the healing speed of the wound is accelerated. The dressing has the effects of ventilation, water resistance, moisture retention and hemostasis, and can promote wound healing and relieve pain.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
A wound wet dressing comprising, in order from far to near to a wound: a back lining layer, a protective layer, a dressing layer and a contact layer;
the dressing layer consists of the following raw materials: sodium alginate, carboxymethyl chitosan, Arabic gum, ferulic acid, glycerol, honey, plant polysaccharide and Chinese medicinal additives.
In some embodiments of the present invention, the coating layer comprises the following raw materials in parts by weight: 40-55 parts of sodium alginate, 18-25 parts of carboxymethyl chitosan, 7-15 parts of Arabic gum, 5-10 parts of ferulic acid, 3-8 parts of glycerol, 5-10 parts of honey, 5-8 parts of plant polysaccharide and 10-15 parts of a traditional Chinese medicine additive.
Sodium alginate and carboxymethyl chitosan are crosslinked, a nano-scale network interpenetrating structure can be prepared, the dispersibility and the stability are good, the drug loading amount is high, other components can be effectively coated, and the stability and the bioactivity of the whole dressing layer are improved.
The unique surface characteristics of gum arabic make it possible to reduce the interfacial tension between different systems, thereby increasing the stability of the material through electrostatic interactions and hydrogen bonds, among others. Arabic gum has antioxidant activity, can prevent lipid peroxidation in skin and stimulate wound healing when being applied topically to wounds, has antibacterial activity, can inhibit microbial colonization in wounds and prevent wound infection, and has excellent hydrophilicity, so that it can absorb excessive exudate in wounds.
Ferulic acid belongs to phenolic compounds, is a natural antioxidant, has physiological activities of resisting cancer, inflammation, radiation and bacteria, and can reduce the level of inflammatory reaction mediated by tumor necrosis factor and inducible nitric oxide synthase. The ferulic acid can promote angiogenesis in vivo and in vitro by regulating vascular endothelial growth factor, platelet-derived growth factor and hypoxia inducible factor-1 alpha, and can promote proliferation of endothelial cells by regulating cyclin D1 and vascular endothelial growth factor, thereby achieving the effect of treating wound surface.
The honey adopted by the invention is medical-grade honey, and can promote wound debridement autolysis, stimulate wound tissue growth, reduce pain, inhibit edema and exudate generation and improve the speed of wound healing.
The polysaccharide and polysaccharide derivative containing amino group of plant polysaccharide have excellent biocompatibility and biodegradability, and the amino group of polysaccharide and polysaccharide derivative containing amino group can provide good tissue adhesion, platelet and blood cell adhesion and activation performance for the crystal glue material, and can activate blood cells and activated blood coagulation system of platelets by enriching blood cells and platelets to promote hemostasis.
In some embodiments of the present invention, the plant polysaccharide is angelicae sinensis polysaccharide and/or pachyman. The angelica polysaccharide and the pachyman have stronger anticoagulation and hemostasis effects, and the hemostasis effect is related to the effect of promoting platelet aggregation. The angelica polysaccharide shows bidirectional regulation effect in blood coagulation, and the anticoagulation effect mainly influences an endogenous blood coagulation system, has weak influence on the exogenous blood coagulation system, and can promote platelet aggregation so as to achieve the hemostasis effect.
In some embodiments of the present invention, the traditional Chinese medicine additive comprises the following components in parts by weight: 3-5 parts of thuja, 2-3 parts of purple perilla, 3-4 parts of platycodon grandiflorum and 2-3 parts of green tea. Arborvitae anti-inflammatory and disinfectant, toxin expelling and swelling relieving, purple perilla pain relieving and stasis removing, balloonflower root pus expelling, green tea detoxification; in addition, green tea contains tea polyphenols, caffeine, lipopolysaccharide, theanine, etc., and has analgesic and hemostatic effects.
In some embodiments of the invention, the backing layer is a PU film, which has the characteristics of good elasticity and high lightness, can adapt to joint parts, has the advantages of water resistance and air permeability, can make wounds breathable and free from infection, is transparent and visible, and can be replaced according to the absorption condition of the dressing, so that the dressing is more convenient.
In some embodiments of the present invention, the protective layer is a modified cellulose film layer, and the modified cellulose film layer has strong stability and antibacterial property, and provides strong protection for the wound, so as to prevent bacteria in the air from entering the wound contact layer to cause wound infection.
In some embodiments of the present invention, the contact layer is a silicone gel, a hydrogel, or pectin. The water-soluble polymer particles in the pectin swell into a hydrogel form after absorbing wound exudate, and can maintain a moist wound environment; hydrogels are amorphous water-based gels or sheets that can rehydrate dry necrotic tissue or decay, promote debridement and create a moist wound healing environment; the silicone gel has excellent adhesiveness and softness and adhesion to a wound, does not cause wound damage when removed, and has the characteristics of being recyclable and non-traumatic to skin around the wound, and thus the silicone gel is preferable for painful wounds.
A preparation method of a wound wet dressing comprises the following steps:
modifying cellulose by adopting guanidine salt, then performing suction filtration to form a film, and covering one end of a back lining layer to form a protective layer;
performing ultrasonic treatment on sodium alginate, carboxymethyl chitosan and glycerol to obtain a mixture A, extracting thuja, purple perilla, platycodon grandiflorum and green tea with water to obtain a filtrate, heating and mixing the mixture A with Arabic gum, ferulic acid, plant polysaccharide, honey and the filtrate to obtain a mixture B, concentrating the mixture B, coating the mixture B on a protective layer, and drying to form a dressing layer;
a silicone gel, hydrogel or pectin is coated on the adjuvant layer to form a contact layer.
In some embodiments of the present invention, the preparation method of the protective layer specifically includes: adding 5-8 times of water by mass into bacterial cellulose, crushing, centrifuging to remove supernatant, adding 5-8 times of anhydrous methanol by mass, mixing uniformly, centrifuging to remove supernatant, repeating for 2-3 times, dispersing the separated cellulose into dimethyl sulfoxide, fully stirring, adding carbonyldiimidazole to perform an excitation reaction for 4-6 hours, slowly adding guanidinium (the mass ratio of the bacterial cellulose to the guanidinium is 2: 1), stirring to react for 18-24 hours, centrifuging the reactant to remove supernatant, and sequentially cleaning with clean water and the anhydrous methanol; then adding water, stirring and dissolving, and filtering by adopting a microporous filter membrane to form a membrane.
The cellulose modified by the guanidine salt has better antibacterial property and stability.
In some embodiments of the present invention, the temperature of the heating and mixing is 55 to 65 ℃, and the mixing time is 10 to 20min, and the temperature can sufficiently mix the raw materials.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A preparation method of a wound wet dressing comprises the following steps:
adopting a PU film as a back lining layer;
adding 25g of water into 5g of bacterial cellulose, crushing, centrifuging to remove supernatant, adding 30g of anhydrous methanol, mixing uniformly, centrifuging to remove supernatant, repeating for 3 times, dispersing the separated cellulose into 50mL of dimethyl sulfoxide, fully stirring, adding carbonyldiimidazole to perform an excitation reaction for 6 hours, slowly adding guanidinium (the mass ratio of the bacterial cellulose to the guanidinium is 2: 1), stirring for 24 hours, centrifuging the reactant to remove supernatant, and sequentially cleaning with clear water and the anhydrous methanol; then adding water, stirring and dissolving, and performing suction filtration by using a microporous filter membrane to form a membrane; covering a cellulose membrane at one end of a back lining layer to form a protective layer;
ultrasonically treating 55g of sodium alginate, 18g of carboxymethyl chitosan and 6g of glycerol to obtain a mixture A, carrying out water extraction on 4g of thuja, 2g of perilla, 3g of platycodon grandiflorum and 2g of green tea for 3 times to obtain a filtrate, heating and mixing the mixture A, 10g of Arabic gum, 7g of ferulic acid, 6g of plant polysaccharide (4 g of angelica polysaccharide and 2g of pachymaran), 8g of honey and the filtrate at 60 ℃ for 20min to obtain a mixture B, concentrating the mixture B, coating the mixture B on a protective layer, and drying to form a dressing layer;
and coating the silicone gel on the auxiliary material layer to form a contact layer, and coating release paper on the contact layer to obtain the wound surface moist dressing of the embodiment.
Example 2
A preparation method of a wound wet dressing comprises the following steps:
adopting a PU film as a back lining layer;
adding 40g of water into 5g of bacterial cellulose, crushing, centrifuging to remove supernatant, adding 35g of anhydrous methanol, mixing uniformly, centrifuging to remove supernatant, repeating for 2 times, dispersing the separated cellulose into 60mL of dimethyl sulfoxide, fully stirring, adding carbonyldiimidazole to carry out an excitation reaction for 4 hours, slowly adding guanidinium (the mass ratio of the bacterial cellulose to the guanidinium is 2: 1), stirring for 22 hours, centrifuging the reactant to remove supernatant, and sequentially cleaning by adopting clear water and the anhydrous methanol; then adding water, stirring and dissolving, and performing suction filtration by using a microporous filter membrane to form a membrane; covering a cellulose membrane at one end of a back lining layer to form a protective layer;
ultrasonically treating 40g of sodium alginate, 20g of carboxymethyl chitosan and 8g of glycerol to obtain a mixture A, carrying out water extraction on 3g of thuja, 3g of perilla, 4g of platycodon and 4g of green tea for 3 times to obtain a filtrate, heating and mixing the mixture A, 15g of Arabic gum, 5g of ferulic acid, 8g of plant polysaccharide (pachymaran), 10g of honey and the filtrate at 65 ℃ for 25min to obtain a mixture B, concentrating the mixture B, coating the mixture B on a protective layer, and drying to form a dressing layer;
and coating the silicone gel on the auxiliary material layer to form a contact layer, and coating release paper on the contact layer to obtain the wound surface moist dressing of the embodiment.
Example 3
A preparation method of a wound wet dressing comprises the following steps:
adopting a PU film as a back lining layer;
adding 40g of water into 6g of bacterial cellulose, crushing, centrifuging to remove supernatant, adding 48g of anhydrous methanol, mixing uniformly, centrifuging to remove supernatant, repeating for 3 times, dispersing the separated cellulose into 70mL of dimethyl sulfoxide, fully stirring, adding carbonyldiimidazole to perform an excitation reaction for 5 hours, slowly adding guanidinium (the mass ratio of the bacterial cellulose to the guanidinium is 2: 1), stirring for 18 hours, centrifuging the reactant to remove supernatant, and sequentially cleaning by adopting clear water and the anhydrous methanol; then adding water, stirring and dissolving, and performing suction filtration by using a microporous filter membrane to form a membrane; covering a cellulose membrane at one end of a back lining layer to form a protective layer;
ultrasonically treating 50g of sodium alginate, 25g of carboxymethyl chitosan and 3g of glycerol to obtain a mixture A, carrying out water extraction on 3g of thuja, 3g of perilla, 4g of platycodon grandiflorum and 4g of green tea for 3 times to obtain a filtrate, heating and mixing the mixture A, 15g of Arabic gum, 5g of ferulic acid, 5g of plant polysaccharide (angelica polysaccharide), 5g of honey and the filtrate at 65 ℃ for 30min to obtain a mixture B, concentrating the mixture B, coating the mixture B on a protective layer, and drying to form a dressing layer;
and coating the silicone gel on the auxiliary material layer to form a contact layer, and coating release paper on the contact layer to obtain the wound surface moist dressing of the embodiment.
Example 4
A preparation method of a wound wet dressing comprises the following steps:
adopting a PU film as a back lining layer;
adding 30g of water into 5g of bacterial cellulose, crushing, centrifuging to remove supernatant, adding 40g of anhydrous methanol, mixing uniformly, centrifuging to remove supernatant, repeating for 3 times, dispersing the separated cellulose into 40mL of dimethyl sulfoxide, fully stirring, adding carbonyldiimidazole to carry out an excitation reaction for 4 hours, slowly adding guanidinium (the mass ratio of the bacterial cellulose to the guanidinium is 2: 1), stirring for 19 hours, centrifuging the reactant to remove supernatant, and sequentially cleaning by adopting clear water and the anhydrous methanol; then adding water, stirring and dissolving, and performing suction filtration by using a microporous filter membrane to form a membrane; covering a cellulose membrane at one end of a back lining layer to form a protective layer;
ultrasonically treating 48g of sodium alginate, 20g of carboxymethyl chitosan and 4g of glycerol to obtain a mixture A, extracting 3g of thuja, 2g of purple perilla, 3g of platycodon grandiflorum and 2g of green tea by using water for 2 times to obtain a filtrate, heating and mixing the mixture A, 12g of Arabic gum, 6g of ferulic acid, 7g of plant polysaccharide (angelica polysaccharide), 6g of honey and the filtrate at 655 ℃ for 30min to obtain a mixture B, concentrating the mixture B, coating the mixture B on a protective layer, and drying to form a dressing layer;
and coating the silicone gel on the auxiliary material layer to form a contact layer, and coating release paper on the contact layer to obtain the wound surface moist dressing of the embodiment.
Comparative example 1
This comparative example differs from example 1 in that: in this comparative example, a film made of unmodified cellulose was used as the protective layer.
Comparative example 2
This comparative example differs from example 1 in that: in this comparative example, no protective layer was provided, i.e., the dressing layer was in direct contact with the backing layer.
Comparative example 3
This comparative example differs from example 1 in that: no traditional Chinese medicine additive was added in this comparative example.
Comparative example 4
This comparative example differs from example 1 in that: no plant polysaccharide was added to the dressing layer of this comparative example.
Examples of the experiments
(I) in vitro healing promotion experiment
45 rabbits were selected and randomly divided into 9 groups of 5 rabbits each, and after removing back hair with depilatory, 1% sodium pentobarbital was administered intravenously for anesthesia. The No. 7 syringe needle is adopted to scratch a # type wound surface on the skin surface of a hair removal area of a rabbit at home under an aseptic condition, the dressings prepared in the embodiments 1-4 and the comparative examples 1-4 are placed on a wound part, a filter paper strip is adopted to gently dip and suck until blood does not seep, the required time, namely the bleeding time, is recorded, meanwhile, a blank group is set, and the blank group is not subjected to dressing treatment. Removing the external application after 12h, recording the condition of the wound surface, changing the external application every day for 3 days continuously, removing the external application after 3 days to recover the wound surface naturally, and observing the red swelling, scabbing and decrustation conditions of the wound surface. The results are shown in Table 1.
TABLE 1
As can be seen from Table 1, the dressings prepared in the embodiments 1 to 4 have faster hemostatic ability for wounds, and the dressings prepared in the comparative examples 1 to 4 have inferior effect, wherein particularly the dressing in the comparative example 2 has poor hemostatic effect and poor wound condition after 7 days, which indicates that the protective layer is important for the whole dressing structure.
(II) bacteriostatic test
Standard strains: escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans, and aspergillus niger.
The experimental process comprises the following steps: the zone of inhibition experiment can simulate the ability of the bedsore dressing of the invention to control microbial growth when moist or exuding wounds occur. Each bacterium was inoculated at a concentration of 1X 108/ml onto nutrient agar plates and spread evenly 3 times. The dressings prepared in examples 1 to 5 and comparative examples 1 to 4 were cut into a circular shape having a diameter of 10mm, respectively, placed on a petri dish inoculated with bacteria, and incubated at 37 ℃ with 5% CO2Under the conditions of 24h incubation of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, Candida albicans andafter 3 days of incubation with aspergillus niger, the range of diameters of the zone of inhibition was measured. Each dish was replicated 3 times. The results of the experiment are shown in table 2.
TABLE 2
As can be seen from Table 2, the dressings prepared in examples 1 to 4 of the present invention have a certain antibacterial activity, and compared with comparative examples 1 to 4, the dressings prepared in examples 1 to 4 have a better antibacterial activity.
In summary, the embodiments of the present invention provide a wound wet dressing and a method for preparing the same. The dressing is divided into the back lining layer, the protective layer, the dressing layer and the contact layer, wherein the back lining layer adopts the PU film, the PU film has the characteristics of good elasticity and high lightness, can adapt to joint positions, has the advantages of water resistance and air permeability, can ensure that wounds are ventilated but not infected, and is transparent and visible, can be replaced according to the absorption condition of the dressing and is more convenient. The protective layer is a cellulose membrane of the modified kettle, and has stronger stability and antibacterial property; the auxiliary material layer is crosslinked by adopting sodium alginate and carboxymethyl chitosan, a nano-scale network interpenetrating structure can be prepared, the nano-scale network interpenetrating structure has good dispersibility and stability, the drug loading is high, other components can be effectively encapsulated, the stability and the bioactivity of the whole dressing layer are improved, and then Arabic gum for promoting wound healing, ferulic acid for enhancing the blood coagulation effect, medical-grade honey for promoting wound debridement and autolysis, plant polysaccharide for promoting hemostasis and traditional Chinese medicine additives for diminishing inflammation, relieving pain and expelling pus are added; the contact layer adopts silicone gel, hydrogel or pectin, so that the wettability and the slightly acidic environment of the wound can be maintained, and the healing speed of the wound is accelerated. The dressing has the effects of ventilation, water resistance, moisture retention and hemostasis, and can promote wound healing and relieve pain.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A wound wet dressing, comprising, in order from distal to proximal to a wound: a back lining layer, a protective layer, a dressing layer and a contact layer;
the dressing layer consists of the following raw materials: sodium alginate, carboxymethyl chitosan, Arabic gum, ferulic acid, glycerol, honey, plant polysaccharide and Chinese medicinal additives.
2. A wound wet dressing according to claim 1, wherein the dressing layer comprises the following raw materials in parts by weight: 40-55 parts of sodium alginate, 18-25 parts of carboxymethyl chitosan, 7-15 parts of Arabic gum, 5-10 parts of ferulic acid, 3-8 parts of glycerol, 5-10 parts of honey, 5-8 parts of plant polysaccharide and 10-15 parts of a traditional Chinese medicine additive.
3. A wound wet dressing according to claim 2, characterised in that the plant polysaccharide is angelica polysaccharide and/or pachyman.
4. A wound wet dressing according to claim 2, wherein the traditional Chinese medicine additive comprises the following components in parts by weight: 3-5 parts of thuja, 2-3 parts of purple perilla, 3-4 parts of platycodon grandiflorum and 2-3 parts of green tea.
5. A wound moist dressing according to claim 1, characterised in that the backing layer is a PU film.
6. A wound moist dressing according to claim 1, characterised in that the protective layer is a layer of modified cellulose film.
7. A wound moist dressing according to claim 1, characterised in that the contact layer is a silicone gel, hydrogel or pectin.
8. A method of preparing a moist wound dressing according to any of claims 1 to 7, comprising the steps of:
modifying cellulose by adopting guanidine salt, then performing suction filtration to form a film, and covering one end of a back lining layer to form a protective layer;
performing ultrasonic treatment on sodium alginate, carboxymethyl chitosan and glycerol to obtain a mixture A, extracting thuja, purple perilla, platycodon grandiflorum and green tea with water to obtain a filtrate, heating and mixing the mixture A with Arabic gum, ferulic acid, plant polysaccharide, honey and the filtrate to obtain a mixture B, concentrating the mixture B, coating the mixture B on a protective layer, and drying to form a dressing layer;
a silicone gel, hydrogel or pectin is coated on the adjuvant layer to form a contact layer.
9. A method of preparing a wound moist dressing according to claim 8, characterised in that the protective layer is prepared by a method which is specifically: drying bacterial cellulose, dispersing the bacterial cellulose into dimethyl sulfoxide, adding carbonyldiimidazole to react for 4-6 h, then adding guanidinium, stirring to react for 18-24 h, centrifuging, cleaning, adding water to dissolve, and performing suction filtration to form a film.
10. A method for preparing a moist wound dressing according to claim 8, wherein the temperature of the heating and mixing is 55 to 65 ℃ and the mixing time is 10 to 20 min.
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Application publication date: 20220415 |