CN109432483A - A kind of medical dressing and its preparation method and application accelerating wound healing - Google Patents
A kind of medical dressing and its preparation method and application accelerating wound healing Download PDFInfo
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- CN109432483A CN109432483A CN201811325930.9A CN201811325930A CN109432483A CN 109432483 A CN109432483 A CN 109432483A CN 201811325930 A CN201811325930 A CN 201811325930A CN 109432483 A CN109432483 A CN 109432483A
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- medical dressing
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- calcium ion
- wound
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention belongs to field of medical materials, provide a kind of medical dressing and its preparation method and application for accelerating wound healing, the medical dressing includes reticulated polyester fiber base material and hydrocolloid ingredient, and the hydrocolloid ingredient includes 15-30 parts of chitosan, 10-20 parts of sodium carboxymethylcellulose, 20-55 parts of vaseline and 3-10 parts of anionic additive in parts by weight.For the present invention by combination matching anion, antibacterial components, vitamin and calcium ion, each component is synergistic, enhances antibacterial effect, improves wound tissue cell metabolism, desalinates scar, substantially speed up wound healing.
Description
Technical field
The invention belongs to field of medical materials, it is related to a kind of medical dressing and its preparation method and application, and in particular to one
Kind accelerates medical dressing of wound healing and its preparation method and application more particularly to a kind of antibacterial, inhibits scar and promotes wound
The medical dressing and its preparation method and application of face healing.
Background technique
Antibacterial anti hemorrhagic wound healing is medical field frequently problem, and medical dressing is a kind of for various wounds
The medical material that wound, wound surface are temporarily covered can protect wound to avoid the influence of trauma surface infestation or other foeign elements
Mouth, wound healing.Commercially available bleeding-stopping dressing is generally the simple dressing that common non-woven fabric adds adhered layer to constitute, and relies primarily on
It absorbs the exudates such as wound blood and achievees the purpose that hemostasis, must be treated or be sterilized with composite medicine when necessary.Conventional yarn
Although the dressing such as cloth, bandage are able to satisfy the function of absorbing sepage, but exist simultaneously many deficiencies, such as hygroscopicity is poor, absorb and seep
The dressing surface of liquid is easy bacterial infection, and applies easily cause wound adhesion in wound surface for a long time, and dressing difficulty is big, increases and suffers from
Person is ailing, wastes time and material.
CN103305963A disclose a kind of chitosan health-care fiber capable of releasing negative ion and far infrared application and its
Preparation method, it is characterized in that being prepared by following raw material in parts by weight: chitin: 20-60；Sodium alginate (gelatin): 30-
60；Anionic additive: 0.5-10；Auxiliary agent: 1-15；Coconut husk Carbon fibe: 0-10.This method preparation have release anion and
Biodegradable, biocompatibility and bioactivity of the chitosan health-care fiber of far-infrared functional in addition to possessing chitin
Outside, and referred to as " air vitamin " or " long-lived element " anion and the telangiectasis for making people can be discharged, promotes blood
Liquid circulation, strengthens the metabolism between each tissue, increases the power of regeneration of tissue, improves the immunocompetence of body, adjusts essence
The exaltation state of mind, plays the coconut husk Carbon fibe of medical care effect.This product is adjustable the air quality of ambient enviroment, produces
The absorbent far infrared of stranger's body, human activin cell promote microcirculation in human body, improve function of human body, strengthen immunity.
CN107951945A discloses a kind of external application Chinese medicine gel dressing, it is characterised in that by hydrogel and is dispersed in
Herb powder composition in hydrogel；By weight, the group of the herb powder becomes SEMEN HYGROPHILAE 25-30 parts, Cortex Phellodendri 25-30
Part, 3-5 parts of borneol, the hydrogel is by 25 parts of sodium carboxymethylcelluloses, 0.45 part of ethylparaben, 10 parts of propylene glycol, 0.6 part
Urea, 10 portions of mannitol, 10 parts of ascorbic acid and 23 parts of glycerine are made.The external application Chinese medicine gel dressing is burst for treating skin
Ulcer and bedsore safely and effectively can rapidly promote skin ulcer and bedsore wound heal, but traditional Chinese medicinal components stability is poor, influences
Dressing effect.
CN106975101A discloses a kind of Tourmaline/chitosan hydrochloride compound spray-type aqua dressing, belongs to compound
Aqua wound dressing technical field.The technical problems to be solved by the invention are to provide a kind of suitable art of wound dressings application
Composite spraying type aqua dressing.In the invention composite spraying type aqua dressing, chitosan hydrochloride plays blood coagulation hemostasis, antibacterial disappears
Scorching, film forming effect；Tourmaline plays the role of emitting far-infrared, generation anion, promotes cell growth and wound healing；
PVP plays the role of film forming agent, dispersing agent and adhesive in a small amount of auxiliary material polyvinylpyrrolidone (PVP) ethanol solution.System
Composite spraying type aqua dressing is easy to use, small to skin irritation, film forming speed is fast made of standby, and there is good antibacterial to disappear
Scorching, blood coagulation anastalsis, energy is emitting far-infrared, generates anion, promotes cell growth and wound healing, breathes freely thoroughly after film forming
Wet performance is good, can be used as biological wound dressing.But the negative ion concentration that tourmaline induction generates in the dressing is low, and the dressing
Poor flexibility, sepage managerial ability are weak.
Therefore it provides a kind of good anti-bacterial effect, wound healing can be rapidly promoted, good biocompatibility and tack is good, effect
The stable medical dressing of fruit is of great significance and vast market prospect.
Summary of the invention
In view of the deficiencies of the prior art and actual demand, the present invention provide a kind of medical dressing for accelerating wound healing and
Preparation method and application, rationally, each component is synergistic, gained medical dressing antibacterial effect for medical dressing formula of the invention
It is good, can rapidly promote wound healing, good biocompatibility and tack is good, the medical dressing of effect stability be of great significance and
Vast market prospect.
To achieve this purpose, the present invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of medical dressing for accelerating wound healing, the medical dressing includes netted poly-
Ester fiber substrate and hydrocolloid ingredient, the hydrocolloid ingredient include 15-30 parts of chitosan, carboxymethyl cellulose in parts by weight
10-20 parts of sodium, 20-55 parts of vaseline and 3-10 parts of anionic additive.
In the present invention, chitosan, sodium carboxymethylcellulose, vaseline and anionic additive is applied in combination, in the present invention
Under the cooperation of each component parts by weight, the hydrocolloid management sepage ability of formation is good, and dressing of the present invention and the surface of a wound
Conjugation is high, adhesion wound, promotes surface of a wound local microcirculation by anionic additive, stimulates metabolic pathway, accelerates the surface of a wound
Healing.
Preferably, the hydrocolloid ingredient includes 15-30 parts of chitosan, sodium carboxymethylcellulose 10-20 in parts by weight
Part, 20-55 parts of vaseline and 3-10 parts of anionic additive.
The mass fraction of the chitosan is 15-30 parts, such as can be 15 parts, 18 parts, 20 parts, 22 parts, 24 parts, 25
Part, 27 parts, 29 parts or 30 parts, preferably 20-25 parts.
The parts by weight of the sodium carboxymethylcellulose be 10-20 parts, such as can be 10 parts, 11 parts, 12 parts, 13 parts,
14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts, preferably 15-20 parts.
In the present invention, within the scope of the parts by weight of the chitosan and sodium carboxymethylcellulose, the hydrocolloid bullet of formation
Property it is good, it is adaptable, can be bonded the surface of a wound, absorb sepage, keep the surface of a wound wet, promote the healing of the surface of a wound.
The parts by weight of the vaseline are 20-55 parts, such as can be 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45
Part, 50 parts or 55 parts, preferably 30-40 parts.
The parts by weight of the anionic additive be 3-10 parts, such as can be 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts,
9 parts or 10 parts, preferably 5-8 parts.
Preferably, the hydrocolloid ingredient further includes antibacterial components, vitamin and calcium ion.
Anionic additive is usually used in cosmetics, can promote skin metabolism, improves blood circulation, effectively removes skin
The yellow black element of skin, the epidermal cell eliminating facial dirt and falling off reduce wrinkle, and in the present invention, anionic additive is used
In medical dressing, anion can act synergistically with antibacterial components, vitamin, calcium ion respectively, and anion is used alone and adds
Add the antimicrobial efficiency of agent low, rate of release is slow, and anion cooperation A.SAP can dramatically increase antibacterial effect, realize that spectrum is antibacterial,
Prevent trauma surface infestation.
Preferably, the hydrocolloid ingredient further includes 3-8 parts of antibacterial components, vitamin 1-5 and calcium ion in parts by weight
0.1-1 parts.
In the present invention, anion and calcium ion can cooperate within the scope of the weight proportion and promote surface of a wound microcirculation, adjust
Wound tissue metabolic pathway accelerates wound healing, and anion and calcium ion are provided with the effect for promoting metabolism, but are used alone negative
Parts by weight needed for ion or calcium ion are excessively high, increase cell metabolism load, and by two kinds of components according to quality of the present invention
Proportion can be synergistic, while reducing the dosage of two kinds of components, does not influence histiocytic normal metabolic activity.
The parts by weight of the antibacterial components are 3-8 parts, such as can be 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 8 parts.
The parts by weight of the vitamin are 1-5 parts, such as can be 1 part, 2 parts, 3 parts, 4 parts or 5 parts.
The parts by weight of the calcium ion are 0.1-1 parts, such as can be 0.1 part, 0.3 part, 0.5 part, 0.8 part or 1 part.
Preferably, the antibacterial components include nano silver, A.SAP, zinc oxide, ε-poly-D-lysine or TiO 2 carrying silver
Any one of or at least two combination, preferably A.SAP.
In the present invention, A.SAP is natural organic spectrum antibacterial component, to Escherichia coli, candida albicans, pneumonia feeling, mould,
A variety of bacterium such as green pus bacterium have good antibacterial effect, lower than traditional antibacterial components toxicity, and effect is stronger, in the present invention, preferably
A.SAP is antibacterial components, synergistic with the chitosan in hydrocolloid component, chitosan is used alone, content is needed to be up to 90%
The above competence exertion antibacterial action, but the chitosan of high-content is unfavorable for hydrocolloid and is formed, while economic cost is high, and pass through shell
Synergetic antibacterial effect can occur under the cooperation of the parts by weight for glycan and A.SAP, improve dressing antibacterial effect, realize to wound
The multiple protective in face.
Preferably, the vitamin includes the group of any one of vitamin A, vitamin C or vitamin E or at least two
It closes, preferably vitamin A and ascorbic combination.
Preferably, the vitamin A and ascorbic mass ratio are 1:(1-3), such as can be 1:1,1:2 or 1:3.
In the present invention, vitamin A and vitamin C is applied in combination, acts synergistically with anionic additive, of the present invention
Quality is than can effectively prevent scar, wound healing in range.
Preferably, the calcium ion includes calcium chloride and/or nanometer calcium carbonate.
In the present invention, calcium ion and anion all have the effect of promoting surface of a wound microcirculation, but match in the parts by weight
It closes in range, healing speed is fast, and scar is shallow, and surface of a wound recovery situation is good.
Second aspect, the present invention provide a kind of method for preparing medical dressing as described in relation to the first aspect, the method packet
Include following steps:
(1) vaseline is heated and softened into obtain Albolene；
(2) sodium carboxymethylcellulose and chitosan are added into Albolene obtained by step (1), is mixed, heating
Melting, vacuum defoamation；
(3) vacuum defoamation fusant obtained by step (2) is coated on reticulated polyester fiber base material, obtains substrate net；
(4) spray is in step after anionic additive, antibacterial components, vitamin and calcium ion being prepared into biological active microsphere
Suddenly (3) described substrate is online, obtains medical dressing.
Preferably, the temperature of step (1) described heating is 120-180 DEG C, for example, can be 120 DEG C, 130 DEG C, 140 DEG C,
150 DEG C, 160 DEG C, 170 DEG C or 180 DEG C.
Preferably, the temperature of step (2) described heating be 120-150 DEG C, such as can be 120 DEG C, 130 DEG C, 140 DEG C or
150℃。
Preferably, the preparation method of the biological active microsphere includes the following steps:
Anionic additive, antibacterial components, vitamin, calcium ion and polyethylene glycol 400 are dissolved in deionized water by (1 '), are obtained
Inner aqueous phase W1；Lactic acid-hydroxyacetic acid copolymer is added in dichloromethane-acetone mixture and obtains oily phase O；By the water-soluble of polyvinyl alcohol
Liquid is as outer aqueous phase W2；
Inner aqueous phase W1 is added in the oily phase O in (2 '), and ultrasound under ice bath obtains colostrum W1/O；
Step (2 ') described colostrum W1/O is added in (3 ') in outer aqueous phase W2, stirs under ice bath, obtains emulsion W1/O/W2；
Step (3 ') described emulsion W1/O/W2, solvent flashing is added in (4 ') in sodium chloride solution, and filtering obtains biological work
Property microballoon.
Preferably, the partial size of step (the 4 ') biological active microsphere is 20-50 μm, such as can be 20 μm, 30 μm, 40
μm or 50 μm.
The third aspect, the present invention provide the medical dressing of one kind as described in relation to the first aspect and are used to prepare treatment surgical wound
The purposes of drug and/or reagent.
Compared with prior art, the invention has the following beneficial effects:
(1) present invention does the main constituents of hydrocolloid using sodium carboxymethylcellulose and chitosan, by the weight
It matches obtained hydrocolloid performance of keeping humidity more preferably, can quickly absorb sepage, reduce the replacement number of medical dressing, reduce patient
Pain, while hydrocolloid oil yarn and surface of a wound compactness can be kept more preferable, anion adds according to corresponding deformation can occur the case where the surface of a wound
Agent is added to significantly improve surface of a wound microcirculation, wound healing；
(2) for the present invention by combination matching anion, antibacterial components, vitamin and calcium ion, each component is synergistic, increases
Strong antimicrobial effect improves wound tissue cell metabolism, desalinates scar, substantially speeds up wound healing.
Specific embodiment
Further to illustrate technological means and its effect adopted by the present invention, below by way of specific embodiment come into
One step illustrates technical solution of the present invention, but the present invention is not limited in scope of embodiments.
Embodiment 1
A kind of medical dressing accelerating wound healing, the medical dressing include reticulated polyester fiber base material and hydrocolloid at
Point, the hydrocolloid ingredient includes: in parts by weight
Vitamin A and ascorbic mass ratio are 1:2；
The medical dressing the preparation method is as follows:
(1) vaseline is heated 150 DEG C and softens to obtain Albolene；
(2) sodium carboxymethylcellulose and chitosan are added into Albolene obtained by step (1), is mixed, heating
140 DEG C of meltings, vacuum defoamation；
(3) vacuum defoamation fusant obtained by step (2) is coated on reticulated polyester fiber base material, obtains substrate net；
(4) spray is in step after anionic additive, antibacterial components, vitamin and calcium ion being prepared into biological active microsphere
Suddenly (3) described substrate is online, obtains medical dressing；
Wherein the partial size of biological active microsphere is 30 μm.
Embodiment 2
A kind of medical dressing accelerating wound healing, the medical dressing include reticulated polyester fiber base material and hydrocolloid at
Point, the hydrocolloid ingredient includes: in parts by weight
Wherein vitamin A and ascorbic mass ratio are 1:2；
The medical dressing the preparation method is as follows:
(1) vaseline is heated 160 DEG C and softens to obtain Albolene；
(2) sodium carboxymethylcellulose and chitosan are added into Albolene obtained by step (1), is mixed, heating
130 DEG C of meltings, vacuum defoamation；
(3) vacuum defoamation fusant obtained by step (2) is coated on reticulated polyester fiber base material, obtains substrate net；
(4) spray is in step after anionic additive, antibacterial components, vitamin and calcium ion being prepared into biological active microsphere
Suddenly (3) described substrate is online, obtains medical dressing；
Wherein the partial size of biological active microsphere is 40 μm.
Embodiment 3
A kind of medical dressing accelerating wound healing, the medical dressing include reticulated polyester fiber base material and hydrocolloid at
Point, the hydrocolloid ingredient includes: in parts by weight
Wherein vitamin A and ascorbic mass ratio are 1:1；
The medical dressing the preparation method is as follows:
(1) vaseline is heated 180 DEG C and softens to obtain Albolene；
(2) sodium carboxymethylcellulose and chitosan are added into Albolene obtained by step (1), is mixed, heating
120 DEG C of meltings, vacuum defoamation；
(3) vacuum defoamation fusant obtained by step (2) is coated on reticulated polyester fiber base material, obtains substrate net；
(4) spray is in step after anionic additive, antibacterial components, vitamin and calcium ion being prepared into biological active microsphere
Suddenly (3) described substrate is online, obtains medical dressing.
Wherein the partial size of biological active microsphere is 20 μm.
Embodiment 4
A kind of medical dressing accelerating wound healing, the medical dressing include reticulated polyester fiber base material and hydrocolloid at
Point, the hydrocolloid ingredient includes: in parts by weight
Wherein vitamin A and ascorbic mass ratio are 1:3；
The medical dressing the preparation method is as follows:
(1) vaseline is heated 120 DEG C and softens to obtain Albolene；
(2) sodium carboxymethylcellulose and chitosan are added into Albolene obtained by step (1), is mixed, heating
150 DEG C of meltings, vacuum defoamation；
(3) vacuum defoamation fusant obtained by step (2) is coated on reticulated polyester fiber base material, obtains substrate net；
(4) spray is in step after anionic additive, antibacterial components, vitamin and calcium ion being prepared into biological active microsphere
Suddenly (3) described substrate is online, obtains medical dressing.
Wherein the partial size of biological active microsphere is 50 μm.
Embodiment 5
Compared with Example 1, in addition to the parts by weight of anionic additive are 1 especially, other conditions are the same as embodiment 1.
Embodiment 6
Compared with Example 1, in addition to the parts by weight of anionic additive are 15 especially, other conditions are the same as embodiment 1.
Embodiment 7
Compared with Example 1, other than antibacterial components are nano silver, other conditions are the same as embodiment 1.
Embodiment 8
Compared with Example 1, other than not adding vitamin A, other conditions are the same as embodiment 1.
Embodiment 9
Compared with Example 1, other than not adding vitamin C, other conditions are the same as embodiment 1.
Embodiment 10
Compared with Example 1, other than vitamin A and ascorbic mass ratio are 3:1, other conditions are the same as embodiment 1.
Embodiment 11
Compared with Example 1, other than vitamin A and ascorbic mass ratio are 1:5, other conditions are the same as embodiment 1.
Embodiment 12
Compared with Example 1, other than not adding calcium ion, other conditions are the same as embodiment 1.
Embodiment 13
Compared with Example 1, other than the partial size of biological active microsphere is 5 μm, other conditions are the same as embodiment 1.
Embodiment 14
Compared with Example 1, other than the partial size of biological active microsphere is 60 μm, other conditions are the same as embodiment 1.
Comparative example 1
Compared with Example 1, in addition to the parts by weight of chitosan are 10 parts, the parts by weight of sodium carboxymethylcellulose are 30
Part, especially for 25, other conditions are the same as embodiment 1 for the parts by weight of vaseline.
Comparative example 2
Compared with Example 1, in addition to the parts by weight of chitosan are 40 parts, the parts by weight of sodium carboxymethylcellulose are 10
Part, especially for 25, other conditions are the same as embodiment 1 for the parts by weight of vaseline.
Comparative example 3
Compared with Example 1, in addition to the parts by weight of chitosan are 20 parts, the parts by weight of sodium carboxymethylcellulose are 15
Part, especially for 10, other conditions are the same as embodiment 1 for the parts by weight of collagen polypeptide.
Comparative example 4
Compared with Example 1, other than not adding anionic additive, other conditions are the same as embodiment 1.
Comparative example 5
Compared with Example 1, other than not adding chitosan, other conditions are the same as embodiment 1.
Comparative example 6
It is tested using the common petrolatum oil gauze without any functional component.
Performance study
1, the medical dressing biological property research of antibacterial wound healing
Referring to GB/T 16886.1-2001 BiologicalEvaluationofMedicalDevice part 1: evaluation and experiment, GB/T
16886.10-2005 the 10th part of BiologicalEvaluationofMedicalDevice: stimulation and delayed allergy experiment, GB/T
The 5th part of 16886.5-2003 BiologicalEvaluationofMedicalDevice: the relevant criterions such as vitro cytotoxicity test implement the present invention
The medical dressing of example 1 carries out the research in terms of biology.
(1) skin irritation is tested
Take sample according to 3cm2/ mL ratio, which is added, meets extraction Jie that the 10.3.4 in GB/T 16886.12-2005 is required
Matter extracts (24 ± 2) h under the conditions of (37 ± 1) DEG C and prepares leaching liquor, and test method is by GB/T after being filtered with funnel
16886.10-2005 the regulation in Appendix B B.2 carries out.It as a result is that the rabbit skin primary stimulus index (PII) of medical dressing is
0, it is non-stimulated.
(2) vitro cytotoxicity test
Take sample according to 3cm2Cell culture fluid is added in/mL ratio, and (24 ± 2) preparation is extracted under the conditions of (37 ± 1) DEG C
Leaching liquor, test method is carried out by GB/T 16886.5-2003 8.2 regulation after being filtered with funnel.It is of the invention as the result is shown
Medical dressing cell-cytotoxic reaction averagely score as 0, no cytotoxicity.
(3) delayed allergy is tested
Take sample according to 3cm2/ mL ratio, which is added, meets extraction Jie that the 10.3.4 in GB/T 16886.12-2005 is required
Matter extracts (24 ± 2) h under the conditions of (37 ± 1) DEG C and prepares leaching liquor, and test method is by GB/T after being filtered with funnel
16886.10-2005 the regulation of 7 chapters carries out in.Medical dressing sensitivity response average score of the invention is 0 as the result is shown, no cause
Quick property.
2, the medical dressing zoopery verifying of antibacterial wound healing
(1) skin ultrastructure is tested:
The male white big ear rabbit of 120 weight 2kg or so is selected, injects 25% from auricular vein by 1g/kg before experiment
Urethane makes animal enter narcosis, and unhairing preserved skin disinfection in back cuts 1 circular wound along backbone two sides with scalpel,
Epidermis undertissue is cut off to fascia, hemostasis, sterile gauze package sub-cage rearing；After the daily nitrofurazone cleaning surface of a wound of operation time,
Rabbit is divided into 20 groups, every group 6, sticks the medical dressing of embodiment 1-14 and comparative example 1-6 respectively to every group of animal, respectively
Wound is recorded in the 0th day and the 7th day area and the frequency of more change dressings, the results are shown in Table 1.
1 wound repair test result of table
As shown in Table 1, comparing embodiment 1 and embodiment 5-6 are it is found that the dosage of anionic additive excessively increases surface of a wound generation
Thank to load, sepage increases, and extends wound healing time, and anionic additive dosage is very few, and anion burst size is insufficient, Bu Nengyu
Vitamin, calcium ion play effective synergistic effect, and medical dressing performance significantly reduces；Comparing embodiment 1 and embodiment 7 can
Know, A.SAP can inhibit microbial reproduction as preferred antibacterial components, keep surface of a wound gnotobasis, promote healing；Comparing embodiment
1 with embodiment 8-11 it is found that vitamin A and vitamin C in the quality than anion can be cooperateed in range, desalinate scar, promote
Into wound healing；Comparing embodiment 1 and embodiment 12 remarkably promote wound it is found that calcium ion and anionic additive synergy
The Absorption And Metabolism to effective component in dressing is accelerated in face microcirculation, accelerates wound healing；Comparing embodiment 1 and embodiment 13-14
It is found that the partial size of biological active microsphere it is too small or it is excessive influence anion, antibacterial components, vitamin and calcium ion collaboration release
It puts；Comparing embodiment 1 and comparative example 1-3 it is found that chitosan, sodium carboxymethylcellulose and vaseline in parts by weight of the present invention
Effect is best in number range, and the elasticity of excessive chitosan or sodium carboxymethylcellulose influence hydrocolloid, vaseline is very few easily to be made
The dressing adhesion surface of a wound；Comparing embodiment 1 and comparative example 4-6 significantly slow wound healing speed it is found that not adding anionic additive
Degree, common Petroleum gauze can only keep the surface of a wound wet, have no significant effect to healing speed.
3, antibacterial tests
The staphylococcus aureus, Escherichia coli and pseudomonas aeruginosa of activation are inoculated in broth medium agar
On plate, 37 DEG C of cultures suitably dilute thallus for 24 hours, with nutrient broth, and 1-7 of the embodiment of the present invention, 12 and comparative example 4-6 is added
Medical dressing is incubated for 60min under room temperature, and 50 μ L is taken to be coated with for plate respectively, is inverted culture for 24 hours at 37 DEG C, and observation bacterium colony is raw
Long situation does blank control with sterile water substitution medical dressing, calculates the bacteriostasis rate of each embodiment and comparative example, the results are shown in Table 2.
2 bacteriostatic test result of table
As shown in Table 2, comparing embodiment 1 and embodiment 5-6 are it is found that the dosage of anionic additive influences medical dressing
Antibacterial effect, excessive or how many reduction antibiotic rates；Comparing embodiment 1 and embodiment 7 are it is found that anionic additive and A.SAP
Synergistic effect it is more significant, the antibacterial effect of nano silver is not so good as A.SAP；Comparing embodiment 1 and embodiment 12 it is found that anion with
Calcium ion is synergistic, significantly improves antibiotic rate；Comparing embodiment 1 and comparative example 4 are it is found that anion and antibacterial components, dimension are given birth to
Element, calcium ion have synergistic effect, and dressing effect will be significantly reduced by not adding anionic additive；Comparing embodiment 1 and comparison
Example 5 reduces dressing antibiotic property, while elasticity and the biocompatibility decline of hydrocolloid it is found that not adding chitosan；Compare implementation
Example 1 and comparative example 6 are it is found that common hydrocolloid oil yarn only plays moisture-keeping function, but fungistatic effect is poor.
To sum up, the present invention does the main constituents of hydrocolloid using sodium carboxymethylcellulose and chitosan, by described heavy
The hydrocolloid performance of keeping humidity that amount proportion obtains more preferably, can quickly absorb sepage, reduce the replacement number of medical dressing, reduce and suffer from
Person's pain, while hydrocolloid oil yarn and surface of a wound compactness can be kept more preferable, combination is matched according to corresponding deformation can occur the case where the surface of a wound
Than anion, antibacterial components, vitamin and calcium ion, each component is synergistic, enhances antibacterial effect, improves wound tissue cell
Metabolism desalinates scar, substantially speeds up wound healing.
The Applicant declares that the present invention is explained by the above embodiments method detailed of the invention, but the present invention not office
Be limited to above-mentioned method detailed, that is, do not mean that the invention must rely on the above detailed methods to implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (10)
1. a kind of medical dressing for accelerating wound healing, which is characterized in that the medical dressing includes reticulated polyester fiber base material
With hydrocolloid ingredient, the hydrocolloid ingredient include in parts by weight 15-30 parts of chitosan, 10-20 parts of sodium carboxymethylcellulose,
20-55 parts and anionic additive 3-10 parts of vaseline.
2. medical dressing according to claim 1, which is characterized in that the hydrocolloid ingredient is poly- including shell in parts by weight
20-25 parts sugared, 15-20 parts of sodium carboxymethylcellulose, 30-40 parts of vaseline and 5-8 parts of anionic additive.
3. medical dressing according to claim 1 or 2, which is characterized in that the hydrocolloid ingredient further include antibacterial components,
Vitamin and calcium ion；
Preferably, the hydrocolloid ingredient further includes 3-8 parts of antibacterial components, vitamin 1-5 and calcium ion 0.1-1 in parts by weight
Part.
4. medical dressing according to claim 1-3, which is characterized in that the antibacterial components include nano silver,
Any one of A.SAP, zinc oxide, ε-poly-D-lysine or TiO 2 carrying silver or at least two combination, preferably
A.SAP。
5. medical dressing according to claim 1-4, which is characterized in that the vitamin includes vitamin A, dimension
The combination of raw element any one of C or vitamin E or at least two, preferably vitamin A and ascorbic combination；
Preferably, the vitamin A and ascorbic mass ratio are 1:(1-3).
6. medical dressing according to any one of claims 1-5, which is characterized in that the calcium ion includes calcium chloride
And/or nanometer calcium carbonate.
7. a kind of method for preparing medical dressing as claimed in any one of claims 1 to 6, described method includes following steps:
(1) vaseline is heated and softened into obtain Albolene；
(2) sodium carboxymethylcellulose and chitosan are added into Albolene obtained by step (1), is mixed, heating melting,
Vacuum defoamation；
(3) vacuum defoamation fusant obtained by step (2) is coated on reticulated polyester fiber base material, obtains substrate net；
(4) spray is in step after anionic additive, antibacterial components, vitamin and calcium ion being prepared into biological active microsphere
(3) substrate is online, obtains medical dressing.
8. the method according to the description of claim 7 is characterized in that the temperature of step (1) described heating is 120-180 DEG C；
Preferably, the temperature of step (2) described heating is 120-150 DEG C.
9. method according to claim 7 or 8, which is characterized in that the preparation method of the biological active microsphere includes such as
Lower step:
Anionic additive, antibacterial components, vitamin, calcium ion and polyethylene glycol 400 are dissolved in deionized water by (1 '), obtain interior water
Phase W1；Lactic acid-hydroxyacetic acid copolymer is added in dichloromethane-acetone mixture and obtains oily phase O；The aqueous solution of polyvinyl alcohol is made
For outer aqueous phase W2；
Inner aqueous phase W1 is added in the oily phase O in (2 '), and ultrasound under ice bath obtains colostrum W1/O；
Step (2 ') described colostrum W1/O is added in (3 ') in outer aqueous phase W2, stirs under ice bath, obtains emulsion W1/O/W2；
Step (3 ') described emulsion W1/O/W2, solvent flashing is added in (4 ') in sodium chloride solution, and it is micro- to obtain bioactivity for filtering
Ball；
Preferably, the partial size of step (the 4 ') biological active microsphere is 20-50 μm.
10. drug and/or examination that a kind of medical dressing as claimed in any one of claims 1 to 6 is used to prepare treatment surgical wound
The purposes of agent.
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| WO2021045714A1 (en) * | 2019-09-03 | 2021-03-11 | Aksoy Sena Dilek | Surgical wound covering pad with negative ion cartridge |
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