CN101278896B - Chitosan nano silver gel agent and uses thereof - Google Patents
Chitosan nano silver gel agent and uses thereof Download PDFInfo
- Publication number
- CN101278896B CN101278896B CN2008100162566A CN200810016256A CN101278896B CN 101278896 B CN101278896 B CN 101278896B CN 2008100162566 A CN2008100162566 A CN 2008100162566A CN 200810016256 A CN200810016256 A CN 200810016256A CN 101278896 B CN101278896 B CN 101278896B
- Authority
- CN
- China
- Prior art keywords
- chitosan
- nano silver
- gel
- acid
- nanometer silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a chitosan nano silver gelata used for treating an inflammation in a lower genital tract, cervicitis and cervical erosion of female and empyrosis, scalding, bedsore infection and other skin inflammations such as tinea manus and pedes, and various wound infections, etc. The medicinal raw materials of the chitosan nano silver gelata of the invention are the nano silver and chitosan polymer in respective therapy dose; the nano silver is the nano silver powder or the nano silver colloid; the chitosan polymer is the chitosan and the chitin and one or more than one derivative of the chitosan and the chitin. The product of the invention has the advantages of high efficiency and being nonpoisonous, and has an extremely strong antibacterial action and an excellent therapeutic effect; compared with other nano silver gelata, the chitosan nano silver gelata of the invention has the advantages of perfect sterilizing effect, long-lasting effect and tissue repair function.
Description
Technical field
The present invention relates to a kind of chitosan nano silver gel agent, be used for treating urogenital tract infection under the women, cervicitis, cervical erosion and burn, scald, decubital ulcer infection and other scytitiss such as tinea manus and pedis, various traumatic infections etc.
Background technology
Urogenital tract infection under the women, cervicitis, cervical erosion sickness rate are higher, are the commonly encountered diseases in the gynaecopathia.At present, the treatment product is more on the market, but therapeutic effect is undesirable, and relapse rate is higher.
The incidence rate of burn and scald, decubital ulcer patient infection is higher, and more use antibiotic is prone to produce drug resistance, is difficult to disease controlling.
The scytitis kind is more, the big and easy relapse of treatment difficulty, and a lot of scytitiss do not have the specific antibacterial medicine.
Silver has intensive bactericidal effect, can kill 600 various bacteria, and can not produce drug resistance.Its sterilization mechanism is that silver combines to make it to lose activity with the interior sulfydryl enzyme of bacterial body, makes bacterial death; The Peptidoglycan reaction that exposes on silver and the bacteria cell wall forms the reversibility complex, makes them not advance cell to oxygen (energy) transhipment, stops the activity of pathogenic bacteria, causes its death; The DNA of silver and pathogenic bacterium combines, and causes the dna structure degeneration, and reproducible does not make the pathogenic bacterium inactivation.
Chitosan also has bactericidal action, and under acid condition, the amino in the chitosan molecule has positive charge, becomes NH
3+, absorption has the antibacterial of negative charge, makes the negative charge skewness on bacteria cell wall and the cell membrane; Synthesizing of interference cell wall; Break the synthetic and dissolution equilibrium of cell wall under naturalness, make cell wall trend towards dissolving, cell membrane is not because of bearing the osmotic pressure deformation fracture; Content such as water, the protein etc. of cell ooze out, and bacterolysis take place and death.
At the disclosed patent of the 2005.9.28 of the Intellectual Property in China office " nano silver antimicrobial gel of treatment women ' s genital tract infection; Method for preparing and application " in (publication number CN1672689); Disclose with nanometer silver as antibacterial, carbomer etc. are as the antibacterial gel of figuration material.Used excipient is the artificial-synthetic compound, and does not have antibacterial action, does not have the tissue repair function.
The disclosed patent of the 2005.12.21 of Intellectual Property in China office " Chitosangynaecologicsuppository suppository and preparation method thereof " (CN1709278) in; A kind of chitosan suppository is disclosed; Mainly be that chitosan is placed in the polyoxyethylene monostearate of fusing; Stir, then mixed liquor is poured in the grinding tool, be refrigerated to 8 degree then with compacted under.This suppository uses as the gynaecologic antibiotic agent, does not have nanometer silver in this suppository, and antibacterial effect is not strong.And suppository has limited route of administration, can not be used for the treatment of dermatosis, burn and scald etc.
Summary of the invention
The object of the invention provides a kind of chitosan nano silver gel agent, has good anti-bacterial effect, and duration of efficacy is long, does not have drug resistance, and tissue is had repair function.
Another object of the present invention is to provide above-mentioned chitosan nano silver gel agent using on urogenital tract infection, cervicitis, cervical erosion, burn, scald, ulcer, decubital ulcer infection or the scytitis medicine under the preparation treatment women.
The present invention realizes through following measure:
Chitosan nano silver gel agent of the present invention; Its medicinal raw material is the nanometer silver and the chitosan base polymer of survival dose; Described nanometer silver is nanometer silver powder or nano silver colloid, and described chitosan base polymer is one or more of chitosan and chitin and derivant thereof.
The chitosan nano silver gel of the invention described above, its adjuvant includes gel, wetting agent and diluent, and the hydrotropy acid that is used to dissolve the chitosan base polymer.
The chitosan nano silver gel of the invention described above, described gel are one or more of carbomer, Polycarbophil, cellulose and derivant thereof and Polyethylene Glycol; Described wetting agent is one or more of glycerol, propylene glycol and sorbitol; Described hydrotropy acid is sulphuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, hydrochloric acid, 1,2,3, one or more of 4-BTCA (BTCA) and citric acid (CA).
The chitosan nano silver gel of the invention described above, described nanometer silver weight content is 1ppm-1000,000ppm is preferably 10ppm-2000ppm nanometer silver particle diameter between 1-100nm; Described chitosan base polymer concentration is 0.1mg-990mg/g, is preferably 10mg-600mg/g.
The chitosan nano silver gel of the invention described above, the dispersant of said nano silver colloid are one or more of Polyethylene Glycol, cellulose and derivant thereof, polyvinylpyrrolidone and derivant thereof, polyamide and derivant thereof, clay, collagen protein and pectin.
The present invention also provides a kind of above-mentioned chitosan nano silver gel using on urogenital tract infection, cervicitis, cervical erosion, burn, scald, ulcer, decubital ulcer infection or the scytitis medicine under the preparation treatment women.
In the gel of the present invention, described chitosan base polymer is chitosan and chitin and derivant thereof, and the shell, insecticide crust, fungus, the fly larvae shell that derive from shrimp, Eriocheir sinensis are medium, but it is unrestricted to originate.Chitin, chitosan can have other titles.Chitosan is the deacetylation derivative of chitin, and deacetylation position, degree can be different, but are commonly referred to as chitosan.
In the chitosan nano silver gel agent of the present invention; The cross-linking agent that chitosan can use chitin, chitin derivativ and their catabolite, crosslinked production takes place with other chemical compounds replaces; Like chitosan and cross-linking of starch thing etc., but be not limited to starch with other crosslinked chemical compounds such as chitosans; Chitosan also can use the cross-linking products between chitin, chitin derivativ and their catabolite to replace.Cross-linking products can use physical method crosslinked, and also available cross-linking agent is crosslinked, and when using cross-linking agent, the cross-linking agent kind is unrestricted.During cross-linking reaction, can also use catalyst, catalyst type is unrestricted.
In the chitosan nano silver gel agent of the present invention, this gel has certain viscosity, and the viscosity of gel is greater than 50mPaS.
Method for preparing of the present invention:
Chitosan nano silver gel agent of the present invention; Its preparation method is: chitosan is dissolved in the dilute acid soln; Fully add after the swelling in the agitator, nanometer silver (powdery or colloidal sol shape) is added in the agitator, add diluent and make nanometer silver, chitosan content reach requirement; Fully stir and make nanometer silver chitosan mix homogeneously, form gel; Promptly form chitosan nano silver gel of the present invention, packing gets final product then.Another kind of method for preparing is: chitosan, dilute acid soln, nanometer silver (powdery or colloidal sol shape), diluent are added in the agitator, after fully stirring makes the abundant swelling of chitosan, form gel; Promptly form chitosan nano silver gel of the present invention, packing then.
Can be contained in after gel makes in the gel device, be made up of for gel device sleeve pipe, boosting bar, cannula tip has protective cap.The gel device external form is more elongated, the top is mellow and full, is fit to vagina administration.Gel is pre-loaded in the sleeve pipe, with push rod and sleeve combination, through push rod the chitosan nano silver gel is directly pushed intravaginal during use.
Also can pack into after gel makes in the plastic-aluminum flexible pipe, be used to burn, scald, decubital ulcer infection, the treatment of other scytitiss, various traumatic infection treatments etc.
Antibiotic mechanism of the present invention has following several reasons:
1. chitosan molecule is under acid condition, and its amino becomes positively charged-NH3
+, adsorb electronegative cell wall, make chitosan be adsorbed on surface of cell membrane and form one deck polymeric membrane; Changed the selection permeability of cell membrane; Stop nutrient substance to intracellular transportation, cause Cytoplasm loss, cell plasmolysis, thereby play the bacteriostasis and sterilization effect.
2. chitosan has anionic Cytoplasm through infiltrating in the cyton in the adherent cell body, and the normal physiological activity of flocculation upset cell takes place, thus kill bacteria.
3. silver combines to make latter's inactivation with the interior sulfydryl enzyme of microorganism, and the energy metabolism and the cell wall of blocking-up microorganism are synthetic, play the effect of kill bacteria, virus and eukaryotic microorganisms.
4. the Peptidoglycan reaction that exposes on silver and the bacteria cell wall forms the reversibility complex, makes them not advance cell to oxygen (energy) transhipment, stops the activity of pathogenic bacteria, causes its death.
5. silver and the DNA of pathogenic bacterium combination form cross-linkedly with the bonded silver ion of DNA base each other, cause the dna structure degeneration, suppress it and duplicate, and make the pathogenic bacterium inactivation.
Product of the present invention also has the tissue repair function, and silver can promote epithelium regeneration and tissue repair, thereby promotes wound and rotten to the corn healing.Chitosan has activating cell function, immune cell activated, in injured human body, can induce special cells, promotes wound repair, increases the wound healing ability, and product of the present invention does not have drug resistance.。
Product of the present invention is used to treat the curative effect that urogenital tract infection under the women, cervicitis, cervical erosion etc. have remarkable excellence.Gel of the present invention can pass through the direct administration of vagina, and the nanometer-level silver particle diameter is little, and specific surface area is big, has increased and the pathogenic bacteria touch opportunity, has strengthened bactericidal effect.Chitosan is through its charged NH3
+Combine with the anion of bacteria cell wall, kill gram negative bacteria, positive bacteria, and chitosan repair function in a organized way, can promote the healing of wound, repair rotten to the corn face.The nanometer silver broad-spectrum antiseptic all has exhibited strong inhibition, killing action to gram negative bacteria, gram positive bacteria, fungus, infusorian etc.Product of the present invention also has slow releasing function, and chitosan is a macromolecular polysaccharide, and nanometer silver is had slow-release function, can prolong the release of nanometer silver, and therapeutic effect is more remarkable.Gel avirulence of the present invention, no anaphylaxis, nonirritant, and have the tissue repair function, can promote the healing of rotten to the corn face.So product of the present invention is rapid-action, therapeutic effect good, do not have toxic and side effects, treat longer duration, can strengthen tissue repairing ability, do not influence the vagina normal flora and PH, bactericidal action are not influenced by pH value.
Product of the present invention also can be treated various infection except urogenital tract infection under the treatment women, like skin infection etc.This product also can be used for cosmetics, and chitosan generates cation in rare weak acid, forms polyelectrolyte, has very high moisture absorption and moisture-keeping function, and also has antibacterial action, and skin is not had zest.Acarid often causes that skin of face is red and swollen, and a small amount of nanometer silver can be killed pathogen by skin permeation, the reaction that reduces inflammation, the chitosan reparation skin of can preserving moisture.Product of the present invention all has exhibited strong inhibition, killing action to the inflammation that antibacterial, fungus, virus or parasite etc. cause.
Clinical trial certificate, product of the present invention is efficient, nontoxic, has extremely strong antibacterial action and excellent therapeutic effect, compares with other nano silver gel agents, and bactericidal effect is strong, persistent and have the tissue repair function.
Description of drawings
Fig. 1 is boosting bar and telescopic split structural representation to gel device.
Fig. 2 is to the structural representation after the assembling of gel device.
Among the figure, 1 sleeve pipe, 2 boosting bars, 3 plugs, 4 gels, 5 protective caps.
The specific embodiment
Embodiment 1: the manufacture method of chitosan nano silver gel agent
The self-control nanometer silver adopts polyvinylpyrrolidonesolution solution to be dispersed into colloid, content of nanometer silver 40000ppm,
Nano silver colloid: 5g.
Chitosan: 10g
Carbomer: 3g
Ethylene glycol: 2ml
Distilled water: 79g
Acetic acid: 1ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 2000ppm; The concentration of chitosan is 100mg/g.Divide after preparation is accomplished and be filled to in the gel device or in the plastic-aluminum pipe.
The chitosan nano silver gel of above-mentioned preparation can be used to treat urogenital tract infection under the women, cervicitis, cervical erosion, burn, scald, ulcer, decubital ulcer infection or scytitis.
The detailed directions and the consumption of diseases such as treatment cervicitis are: as depicted in figs. 1 and 2, and form for gel device by sleeve pipe 1, boosting bar 2, there is a plug 3 at the middle part of sleeve pipe 1, and the plug front sealing has gel 4, and there is protective cap 5 on telescopic top.The gel device external form is more elongated, the top is mellow and full, is fit to vagina administration.Gel is pre-loaded in the sleeve pipe, with push rod 2 and sleeve pipe 1 combination, through push rod the chitosan nano silver gel is directly pushed intravaginal during use.Each consumption 3g, every day 1 time.
The detailed directions and the consumption of diseases such as treatment burn, scald are: gel is applied to the affected part, every day 1 time.
The manufacture method of embodiment 2 chitosan nano silver gel agents
Self-control nanometer silver powder: 1mg
Chitosan: 60g
Glycerol: 2g
Carbomer: 3g
Distilled water: 32g
Acetic acid: 3ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 10ppm; Chitosan concentration is 600mg/g.Divide after preparation is accomplished and be filled to in the gel device or in the plastic-aluminum pipe.
Usage and consumption are with embodiment 1.
The manufacture method of embodiment 3 chitosan nano silver gel agents
Self-control nanometer silver powder: 5g
Chitin: 1g
Polyethylene Glycol: 3g
Distilled water: 91.5g
Phosphoric acid: 0.5ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 50000ppm; Chitosan concentration is 10mg/g.Divide after preparation is accomplished and be filled to in the gel device or in the plastic-aluminum pipe.
Usage and consumption are with embodiment 1.
Embodiment 4: the manufacture method of chitosan nano silver gel agent
Self-control nanometer silver: 20mg
Carboxymethyl chitosan: 80g
Carbomer: 2g
Ethylene glycol: 1ml
Distilled water: 13g
Hydrochloric acid: 4ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 200ppm; The concentration of carboxymethyl chitosan is 800mg/g.Divide after preparation is accomplished and be filled to in the gel device or in the plastic-aluminum pipe.
Usage and consumption are with embodiment 1.
Test case 1
Product to embodiment 1-4 carries out the in-vitro antibacterial experiment, and experimental result is as shown in table 1.
The in-vitro antibacterial experimental result of table 1 embodiment 1-4
Test case 2
Product to embodiment 1-4 has carried out the experiment of nanometer silver slow release according to the method among two appendix XD of Pharmacopoeia of the People's Republic of China version in 2005, and the result is as shown in table 2.
The external slow release experiment of table 2 embodiment 1-4 product
Embodiment 1-4 product promotes cell proliferation experiment, and the result is as shown in table 3.
The cell proliferation experiment of table 3 embodiment 1-4 product
Claims (3)
1. the chitosan nano silver gel is being used on urogenital tract infection, cervicitis, cervical erosion, ulcer, decubital ulcer infection or the scytitis medicine under the preparation treatment women: the medicinal raw material of said chitosan nano silver gel is the nanometer silver and the chitosan base polymer of survival dose; Described nanometer silver is nanometer silver powder or nano silver colloid, and described chitosan base polymer is a chitosan; Described nanometer silver weight content is 1ppm-1000,000ppm, and the nanometer silver particle diameter is between 1-100nm; Described chitosan base polymer concentration is 0.1mg-990mg/g;
Its adjuvant is selected from gel, wetting agent and diluent, and the hydrotropy acid that is used to dissolve the chitosan base polymer; Described gel is one or more of carbomer, Polycarbophil, cellulose and Polyethylene Glycol; Described wetting agent is one or more of glycerol, propylene glycol and sorbitol; Described hydrotropy acid is sulphuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, hydrochloric acid, 1,2,3, one or more of 4-BTCA and citric acid.
2. application according to claim 1, described nanometer silver weight content is 10ppm-2000ppm, the nanometer silver particle diameter is between 1-100nm; Described chitosan base polymer concentration is 10mg-600mg/g.
3. application according to claim 1 is characterized in that: the dispersant of said nano silver colloid is one or more of Polyethylene Glycol, cellulose, polyvinylpyrrolidone, polyamide, clay, collagen protein and pectin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100162566A CN101278896B (en) | 2008-05-23 | 2008-05-23 | Chitosan nano silver gel agent and uses thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100162566A CN101278896B (en) | 2008-05-23 | 2008-05-23 | Chitosan nano silver gel agent and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101278896A CN101278896A (en) | 2008-10-08 |
| CN101278896B true CN101278896B (en) | 2012-11-14 |
Family
ID=40011686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100162566A Active CN101278896B (en) | 2008-05-23 | 2008-05-23 | Chitosan nano silver gel agent and uses thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101278896B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773520B (en) * | 2010-03-05 | 2012-01-25 | 沈作兵 | Compound antimicrobial containing polyvalent silver ions and preparation method thereof |
| CN102266283B (en) * | 2011-07-29 | 2012-09-05 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
| CN102552964B (en) * | 2012-01-09 | 2014-04-09 | 李育强 | Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage |
| CN102872159A (en) * | 2012-09-29 | 2013-01-16 | 广东同德药业有限公司 | Nano-silver chitosan gel foam preparation for treating vaginal bacterial inflammation, and preparation method thereof |
| CN102872160A (en) * | 2012-10-26 | 2013-01-16 | 广东同德药业有限公司 | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds |
| CN103006561B (en) * | 2013-01-05 | 2014-07-02 | 华绣科技有限公司 | Lipofectin nanometer silver gel and preparation method thereof |
| CN103301502A (en) * | 2013-06-18 | 2013-09-18 | 王珍 | Gynecological medical gel dressing and preparation method thereof |
| CN103316033B (en) * | 2013-07-03 | 2015-07-15 | 康晓飞 | Gel and use thereof |
| CN103480032B (en) * | 2013-09-25 | 2016-05-25 | 南阳市汇博生物技术有限公司 | A kind of argentiferous plural gel dressing and preparation method thereof |
| CN103586461B (en) * | 2013-11-16 | 2016-01-20 | 华中科技大学 | A kind of nano silver colloidal sol and preparation and purification method thereof |
| CN104306324A (en) * | 2014-10-10 | 2015-01-28 | 无锡贝迪生物工程有限公司 | Medical collagen gel and preparation method thereof |
| CN104910404B (en) * | 2015-06-24 | 2018-04-27 | 武汉工程大学 | A kind of chitosan-glycerine-nano silver sponge and its preparation method and application |
| CN104922151A (en) * | 2015-07-22 | 2015-09-23 | 赵立 | Externally applied hydrogel preparation for women and preparing method thereof |
| CN105820352B (en) * | 2016-04-06 | 2018-08-17 | 南京林业大学 | A kind of preparation method of electropositive chitin nanofiber hydrogels and aeroge |
| CN105903068A (en) * | 2016-06-02 | 2016-08-31 | 四川奎星医用高分子制品有限责任公司 | Medical composite chitosan gel containing analgesic drug |
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
| CN106039394A (en) * | 2016-06-02 | 2016-10-26 | 四川奎星医用高分子制品有限责任公司 | Medical composite chitosan gel containing antibacterial drug |
| CN106137948A (en) * | 2016-08-01 | 2016-11-23 | 中国人民解放军第三军医大学 | The gel for the treatment of dermatitis and eczema and Preparation method and use |
| CN106581039B (en) * | 2016-11-02 | 2020-01-14 | 上海陶盛生物技术有限公司 | Application of carboxymethyl chitosan in preparing antiallergic product |
| CA3066321A1 (en) | 2017-07-19 | 2019-01-24 | Universidade Da Beira Interior | Film for topical application in the treatment of skin lesions and method of obtaining and applying it |
| CN107675292B (en) * | 2017-09-28 | 2018-09-18 | 安徽省银锂子生物科技发展有限公司 | A kind of nano-silver bamboo charcoal fiber and its Bactericidal underwear product |
| CN108902179A (en) * | 2018-08-10 | 2018-11-30 | 张家港市汇鼎新材料科技有限公司 | A kind of preparation method of silver-chitosan composite antibiotic material |
| CN112294843A (en) * | 2019-12-31 | 2021-02-02 | 河南汇博医疗股份有限公司 | Long-acting wound antibacterial gel and preparation method thereof |
| CN113354839B (en) * | 2020-08-26 | 2022-08-23 | 胶原蛋白(武汉)生物科技有限公司 | Collagen-silver nanoparticle composite gel, preparation method and application |
| CN111956616A (en) * | 2020-09-08 | 2020-11-20 | 山西振东泰盛制药有限公司 | Arbidol hydrochloride composite dry powder preparation, spray, gel and preparation method thereof |
| CN112593321A (en) * | 2020-11-26 | 2021-04-02 | 福建省长乐市泰源纺织实业有限公司 | Anti-radiation antibacterial yarn and spinning process thereof |
| CN113244268A (en) * | 2021-04-12 | 2021-08-13 | 青岛海洋生物医药研究院股份有限公司 | Bacteriostatic gel containing sulfated polysaccharide-nano silver complex and application thereof |
| CN116099030A (en) * | 2022-11-15 | 2023-05-12 | 青岛海诺生物工程有限公司 | Chitosan breathable adhesive bandage and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583332A (en) * | 2004-06-08 | 2005-02-23 | 陈丽琼 | Nanometer silver sol and preparing method thereof |
| CN1600477A (en) * | 2003-09-28 | 2005-03-30 | 中国印钞造币总公司 | Method for preparing nano silver powder |
| CN1672689A (en) * | 2004-03-26 | 2005-09-28 | 深圳市爱杰特医药科技有限公司 | Nano silver antiseptic gel for treating women's genital tract infection and its prepn and application |
| CN1706503A (en) * | 2005-05-13 | 2005-12-14 | 褚省吾 | Antibiotic aerogel dressing of hollow acetate fiber and its prepn |
| CN1709243A (en) * | 2005-07-02 | 2005-12-21 | 杨喜鸿 | Vagina medicine containing ebselen and its use |
| CN1709278A (en) * | 2005-06-06 | 2005-12-21 | 肖建国 | Chitosangynaecological suppository and its preparing method |
| CN1765369A (en) * | 2004-10-25 | 2006-05-03 | 陈添水 | Nano silver gel and its use |
-
2008
- 2008-05-23 CN CN2008100162566A patent/CN101278896B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600477A (en) * | 2003-09-28 | 2005-03-30 | 中国印钞造币总公司 | Method for preparing nano silver powder |
| CN1672689A (en) * | 2004-03-26 | 2005-09-28 | 深圳市爱杰特医药科技有限公司 | Nano silver antiseptic gel for treating women's genital tract infection and its prepn and application |
| CN1583332A (en) * | 2004-06-08 | 2005-02-23 | 陈丽琼 | Nanometer silver sol and preparing method thereof |
| CN1765369A (en) * | 2004-10-25 | 2006-05-03 | 陈添水 | Nano silver gel and its use |
| CN1706503A (en) * | 2005-05-13 | 2005-12-14 | 褚省吾 | Antibiotic aerogel dressing of hollow acetate fiber and its prepn |
| CN1709278A (en) * | 2005-06-06 | 2005-12-21 | 肖建国 | Chitosangynaecological suppository and its preparing method |
| CN1709243A (en) * | 2005-07-02 | 2005-12-21 | 杨喜鸿 | Vagina medicine containing ebselen and its use |
Non-Patent Citations (1)
| Title |
|---|
| 汪道新等.复合纳米银凝胶修复烧伤创面的实验观察和临床应用.《临床外科杂志》.2007,(第08期), * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101278896A (en) | 2008-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101278896B (en) | Chitosan nano silver gel agent and uses thereof | |
| CN103285028B (en) | Composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt and preparation method of composite antibacterial agent | |
| KR101377569B1 (en) | Antimicrobial Wound Dressing and Preparing Method of the Same | |
| CN108158995A (en) | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof | |
| EP3735218B1 (en) | Coordination complexes having microbial activity and incorporable in hyaluronic acid compositions | |
| CN101543658B (en) | Cervical cap for preventing and treating cervical erosion and preparation method thereof | |
| CN104027300A (en) | Antibacterial chitosan gel and preparation method thereof | |
| CN113995744B (en) | Composition and antibacterial application thereof | |
| CN1367018A (en) | Compound preparation of staphylococcolysis enzyme and its preparation method and application | |
| CN102405935B (en) | Protamine compounded preparation, preparation method and application thereof | |
| CN114028546A (en) | Composite polypeptide sterilization preparation and preparation method and application thereof | |
| CN102872160A (en) | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds | |
| CN100396290C (en) | External use anti-bacteria foaming agent for gynecology | |
| Barillo | Topical antimicrobials in burn wound care: a recent history | |
| CN114652767B (en) | Dairy cow nipple medicated bath agent and preparation method thereof | |
| CN110693814A (en) | Veterinary tilmicosin nano-gel breast perfusion agent and preparation method thereof | |
| EP2170081B1 (en) | Antimicrobial compositions | |
| RU2146136C1 (en) | Antiseptic "katapel" | |
| CN106237029B (en) | A kind of aloe antibiotic gel and preparation method thereof | |
| CN109200326A (en) | Dressing and bandage for wound healing | |
| CN107929725A (en) | A kind of environmentally friendly lysine polypeptide skin care thimerosal and its preparation process | |
| CN103768089A (en) | Chitosan antibacterial lotion for gynecology and preparation method thereof | |
| CN107595819A (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| CN102526121A (en) | Wound repair composition and preparation method and application thereof | |
| CN105055713A (en) | Drug composition for preventing or curing bedsore and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 250101 Ji'nan high tech Zone, Shandong Road, No. 2222 Patentee after: Shandong saikesaisi Biological Technology Co., Ltd. Address before: 250101 Shandong city in Ji'nan Province, Lixia District (the New District) to open up the road and the junction of Tianchen Avenue Patentee before: Shandong Success Pharmaceutical Technology Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 250101 No. 2222 Pioneer Road, Jinan High-tech Zone, Shandong Province Patentee after: SEXES BIOLOGICAL TECHNOLOGY CO., LTD. Address before: 250101 No. 2222 Pioneer Road, Jinan High-tech Zone, Shandong Province Patentee before: Shandong saikesaisi Biological Technology Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder |