CN106039394A - Medical composite chitosan gel containing antibacterial drug - Google Patents
Medical composite chitosan gel containing antibacterial drug Download PDFInfo
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- CN106039394A CN106039394A CN201610390999.4A CN201610390999A CN106039394A CN 106039394 A CN106039394 A CN 106039394A CN 201610390999 A CN201610390999 A CN 201610390999A CN 106039394 A CN106039394 A CN 106039394A
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- chitosan
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- antibacterials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention discloses medical composite chitosan gel containing an antibacterial drug. The medical composite chitosan gel comprises components in parts by weight as follows: 0.5-10 parts of a chitosan high-polymer material, 0.05-2 parts of the antibacterial drug, 0-10 parts of a thickening agent, 1-25 parts of a humectant and 53-98.45 parts of purified water. The medical composite chitosan gel containing the antibacterial drug can effectively keep a moist environment for wound healing, promote wound healing and prevent and control wound infection; a dressing adopts the chitosan high-polymer material as a substrate, is supported by the antibacterial drug and integrates advantages of moisture absorption, moisture preservation, bacteriostasis and hemostasis of the chitosan high-polymer material and infection prevention and control functions of the antibacterial drug, so that the gel with excellent performance is prepared.
Description
Technical field
The present invention relates to the technical field of wound dressing, more particularly, relate to a kind of medical multiple containing antibacterials
Close chitosan gel rubber.
Background technology
The skin of human body and mucosa are the barriers maintaining human internal environment stable and stoping microorganism to invade, due to ulcer,
Skin that the reasons such as wound, burn and inflammation cause and mucosa injury, can cause a series of problem of body, such as antibacterial sense
The aggravation of dye, metabolism, moisture and protein excessively runs off, endocrine and immune system dysfunction etc., serious may danger
And life.Should select when skin and mucosa injury suitable dressing cover on wound, it can play holding wound moist environment,
Absorb secretions, alleviating pain and control hemorrhage effect, thus promoting wound healing.
The use of dressing is the important means maintaining the good healing environment of wound.Traditional dressing mainly plays for wound
Isolation and bacteriostasis, but frequently result in wound and be dried, destroy the somatomedin of health and easily stick on cambium,
Dressing can cause the secondary insult of wound when removing.Along with people's living standard and the raising of medical level, people are for dressing
Have higher requirement:
(1) can control and absorb exudate, keep wound moist and without the environment of transudate；
(2) bacteria preventers can be provided, build the good environment of an applicable tissue growth, promote that tissue is raw
Long；
(3) there is the suitable transmitance of gas and steam；
(4) easy to use, adhesion is suitable, does not cause secondary injury；
(5) nontoxic, harmless, non-stimulated.
A kind of high-quality dressing that disclosure satisfy that requirements above of gel dressing, it is therefore necessary to provide one to meet
State and require and have the gel dressing improving performance.
Summary of the invention
In order to solve the various problems that dressing in prior art exists, it is an object of the invention to provide one have prevention and
Control infection effect and Moist healing environment, autolyzed debridement, control scar hyperplasia and physical isolation effect can be provided
Medical recombination chitosan gel containing antibacterials.
The invention provides a kind of medical recombination chitosan gel containing antibacterials, in parts by weight, described medical
Recombination chitosan gel includes following components: 0.5～10 part of chitosan family macromolecule material, 0.05～2 part of antibacterials, 0～
10 parts of thickening agents, 1～25 part of wetting agent and 53～98.45 parts of purified water.
An embodiment of the medical recombination chitosan gel of antibacterials, in parts by weight, institute is contained according to the present invention
State medical recombination chitosan gel and include following components: 1.5～6 parts of chitosan family macromolecule materials, 0.05～1 part of antimicrobial drug
Thing, 0～5 part of thickening agent, 4～15 parts of wetting agents and 73～94.45 parts of purified water.
An embodiment of the medical recombination chitosan gel of antibacterials, described medical Composite Shell is contained according to the present invention
Polysaccharide gel also includes pH adjusting agent, and wherein, the usage amount of described pH adjusting agent is for can adjust described medical recombination chitosan
The pH value of gel is to 2～11.
Contain an embodiment of the medical recombination chitosan gel of antibacterials according to the present invention, described chitosan class is high
At least one in the derivant of chitosan, the salt of chitosan and chitosan of molecular material；The derivant of described chitosan
At least one in carboxymethyl chitosan, isobutyl-chitosan, hydroxypropyl chitosan and hyaluronic acid-like chitosan；Described
The salt of chitosan is selected from chitosan quaternary ammonium salt, chitosan hydrochlorate, chitosan lactate, chitosan acetate, chitosan winestone
Hydrochlorate, Chitosan Sulfate, glutamate, Chitosan citrate., chitosan succinate and chitosan acetyl water
At least one in poplar hydrochlorate；The molecular weight of described chitosan family macromolecule material is 1000～1000000；Preferably, described
The molecular weight of chitosan family macromolecule material is 3000～500000.
An embodiment of the medical recombination chitosan gel of antibacterials, described antibacterials are contained according to the present invention
Being dispersed or dissolved in described medical recombination chitosan gel, wherein, described antibacterials are selected from gentamycin or its salt, the most mould
Element or its salt, amikacin or its salt, fusidic acid or its salt, kanamycin or its salt, policresulen, mupirocin, sulphur
At least one in amine Myron or its salt and clindamycin or its salt.
Contain an embodiment of the medical recombination chitosan gel of antibacterials according to the present invention, described thickening agent is selected from
Starch, alginic acid and salt thereof, arabic gum, tragakanta, agar, cellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose,
Hypromellose, hydroxyethyl cellulose, methylcellulose, carbomer, gelatin, xanthan gum, hyaluronic acid, modified starch, poly-
At least one in sodium acrylate, polyvinyl alcohol, Polyethylene Glycol and polyvidone.
Contain an embodiment of the medical recombination chitosan gel of antibacterials according to the present invention, described wetting agent is selected from
At least one in glycerol, propylene glycol, mannitol, butanediol and sorbitol.
Contain an embodiment of the medical recombination chitosan gel of antibacterials according to the present invention, described pH adjusting agent is
Acid or alkali, wherein, at least one in hydrochloric acid, acetic acid, sulphuric acid, boric acid, lactic acid, citric acid, tartaric acid and malic acid of acid,
At least one in sodium hydroxide, sodium carbonate, sodium bicarbonate, sodium citrate and triethanolamine of alkali.
An embodiment of the medical recombination chitosan gel of antibacterials, described medical Composite Shell is contained according to the present invention
The type of service of polysaccharide gel is amorphous gel, lamellar gel or spray form gel；It is preferably amorphous gel.
An embodiment of the medical recombination chitosan gel of antibacterials, described medical Composite Shell is contained according to the present invention
Polysaccharide gel is applicable to acute otch and chronic wound.
Compared with prior art, the medical recombination chitosan gel containing antibacterials of the present invention can keep effectively
The moist environment of wound healing, promotion wound healing also prevent and control wound infection, and this dressing is with chitosan family macromolecule material
Material is substrate, is aided with antibacterials, combines the advantages such as chitosan family macromolecule material moisture absorption, moisturizing, antibacterial, hemostasis and resists
The effect that bacterium chemoprophylaxis and control are infected, is prepared for the gel of a kind of function admirable.
Detailed description of the invention
All features disclosed in this specification, or disclosed all methods or during step, except mutually exclusive
Feature and/or step beyond, all can combine by any way.
Any feature disclosed in this specification, unless specifically stated otherwise, all can by other equivalence or there is similar purpose
Alternative features is replaced.I.e., unless specifically stated otherwise, an example during each feature is a series of equivalence or similar characteristics
?.
Below the medical recombination chitosan gel that the present invention contains antibacterials is described in detail.
According to the exemplary embodiment of the present invention, in parts by weight, above-mentioned medical recombination chitosan gel includes following group
Point: 0.5～10 part of chitosan family macromolecule material, 0.05～2 part of antibacterials, 0～10 part of thickening agent, 1～25 part of wetting agent
With 53～98.45 parts of purified water.
Wherein, above-mentioned chitosan family macromolecule material is in the derivant of chitosan, the salt of chitosan and chitosan
At least one.In the present invention, for different chitosan derivatives, can add as required or be added without thickening agent.
Preferably, described medical recombination chitosan gel includes following components: 1.5～6 parts of chitosan family macromolecule materials,
0.05～1 part of antibacterials, 0～5 part of thickening agent, 4～15 parts of wetting agents and 73～94.45 parts of purified water.
Specifically, the derivant of chitosan is saturating selected from carboxymethyl chitosan, isobutyl-chitosan, hydroxypropyl chitosan and class
At least one in bright matter acid chitosan；The salt of chitosan is selected from chitosan quaternary ammonium salt, chitosan hydrochlorate, chitosan lactic acid
Salt, chitosan acetate, chitosan tartarate, Chitosan Sulfate, glutamate, Chitosan citrate., shell
At least one in polysaccharide succinate and chitosan acetylsalicylate, but the invention is not restricted to this.Wherein, above-mentioned shell gathers
The molecular weight of saccharide macromolecular material is 1000～1000000, preferably 3000～500000.
It is true that the medical recombination chitosan gel of the present invention is a kind of gel dressing and is a kind of polymer, wherein
Water content is 80～90%, and be translucent shape and without stickiness, has powerful slough hydratability and can effectively play
Autolyzed debridement effect, its high cohesion performance goes for the wound at any position, is primarily adapted for use in and is dried incrustation or has
Rot the wound organized；Presenting black or yellow slough for wound bed and wound that sepage is dried less, it can dissolve soft
Change slough, reach autologous debridement effect；Can be used for the clean wound of a small amount of sepage, apply also for fill hole, chamber and
Sinus tract wound.The many uses of gel dressing are nontoxic, the natural polymer material of no antigen, good biocompatibility, biodegradable
Material is prepared from, such as: Chitosan-phospholipid complex, collagen protein, gelatin, cellulose, alginate etc..Wherein chitosan and
Derivant shows multiple advantage as gel dressing, and it not only has the good advantage keeping wound moist environment, also
There is the multiple function being beneficial to wound healing, such as: holding wound moist environment, promotion healing, hemostasis, antibacterial, suppression cicatrix product
Raw etc..Additionally, chitosan be find up to now uniquely there is alkalescence, natural polysaccharide with positive charge, be widely present in
In the carapace of shrimp, Eriocheir sinensis, insecticide etc., resource is the abundantest, is that to be only second to the second largest natural biological of cellulose in nature organic
Resource, source reduces the price of its raw material widely, and then reduces patient medical cost, is a kind of wound being worthy to be popularized
Dressing base material.
But, the effect in terms of controlling wound infection of the simple chitosan dressing has much room for improvement, in order to adapt to patient couple
In controlling the higher pursuit of infectious effect, the present invention creatively adds in chitosan gel rubber dressing has obvious Perceived control
The antibacterials of dye effect are to realize this purpose.
According to the present invention, it is dispersed or dissolved in antibacterials in medical recombination chitosan gel to realize controlling infection
Effect also makes up chitosan gel rubber deficiency in terms of controlling wound infection.Wherein, antibacterials are dispersed or dissolved in compound
In chitosan gel rubber.Preferably, antibacterials selected from gentamycin or its salt, neomycin or its salt, amikacin or its salt,
Fusidic acid or its salt, kanamycin or its salt, policresulen, mupirocin, mafenide or its salt and clindamycin
Or at least one in its salt, preferably gentamycin or its salt.
The gentamycin added or its salt have clear superiority in terms of controlling the infection of wound and surgical wound: its
One, gentamycin has well for causing the main bacteria seed i.e. staphylococcus aureus of infection, escherichia coli, bacillus pyocyaneus etc.
Killing effect；Its two, the concentration of agents area gentamycin is much larger than the concentration of gentamycin in serum, and toxic and side effects is little, no
It is easily generated drug resistance；Its three, gentamycin is high temperature resistant, belongs to heat stability antibiotic few in number.Additionally, dressing adds
The safety of gentamycin has obtained research and has confirmed, and gentamycin has abroad been applied to the product of collagen dressing.According to literary composition
Offer report, big for celebrating in the wounds such as Colon and rectum operation, breastbone operation, GCCI (gentamicin-collagen implant)
Mycin can effectively arrive the soft tissue of infection site, and local infection sites concentration (with transudate densitometer) is antibacterial much larger than minimum
Concentration MIC, wherein the MIC of gentamycin is 4mg/L, has good therapeutical effect；Research confirms, uses GCCI to be administered local
At infection, the concentration of gentamycin is administered taller than systemic vein, and GCCI be administered after gentamycin dense at local infection
Degree is much larger than the concentration of gentamycin in serum, and toxic and side effects is little；In product Septcoll, gentamycin is with two kinds of multi-forms
Salt exist, be water miscible gentamycin sulfate and hydrophobic Crow phosphoric acid gentamycin respectively so that in GCCI, celebrating is big
Mycin initial release concentration is high and duration of efficacy is longer.Therefore, gentamycin or its salt be applied in dressing to have safety,
Effective feature.
In addition to gentamycin, neomycin, amikacin, kanamycin belong to aminoglycoside antibiotics, such antibiosis
Element is germ killing drugs resting stage, and bacillus pyocyaneus and other aerobic gram negative bacterias are had preferable killing action；Ground, husband west
Acid is a kind of antibiotic with steroid backbone, mainly plays antibacterial action by the synthesis of suppression bacterioprotein, Fu Xidi
Acid is especially extremely sensitive to staphylococcus to the various gram-positive coccis relevant with skin infection, to resistant S Fructus Vitis viniferae
Coccus is also effective, and some gram negative bacteria is also had certain antibacterial action, with other antibiotic without cross resistance, and can
For such as pustule ulcer, furuncle and phyma, wound concurrent infection, tinea barbae, hidradenitis, erythrasma, folliculitis, acne vulgaris, eczema concurrent infection,
Ulcer concurrent infection etc.；Policresulen has broad-spectrum antibacterial action, including common gram positive bacteria, Gram-negative
Bacterium, mycete and virus, policresulen passes through peracid and protein coagulation action breaks down antibacterial, mycete and infusorian, optionally draws
Play downright bad or pathological tissues and the deformation of columnar epithelium albumen, and vasoconstriction and plasma protein solidification can be made to stop blooding, give a piece of bad advice
Dead tissue comes off from affected area, strengthens the agglutination of wound；Mafenide has a broad antifungal spectrum, to multiple Grain-negative and positive bacteria
All effective, bacillus pyocyaneus is had and relatively pretends use, therefore be applied topically to burn infection and suppuration wound surface；Mupirocin be aminoacyl-
The inhibitor of tRNA synzyme (AaRS), it optionally makes antibacterial Isoleucyl-tRNA synthetase (AaRS) inactivate, albumen
The biosynthesis of matter is forced to terminate, and bacteria growing inhibiting is as local topical antibiotic, respond well；Clindamycin is suitable for
In the microbial various infection of gram positive bacteria and anaerobism, such as Skin and soft tissue infection, furuncle, carbuncle, abscess, areolar tissue
Inflammation, wound and post-operative infection etc..
In sum, above-mentioned antibacterials have prominent advantage for controlling to infect, and therefore the present invention is by antibacterials
Join in chitosan gel rubber, it is intended to play chitosan family macromolecule material and Moist healing environment, autolyzed debridement, suppression are provided
While the effect such as scar hyperplasia, physical isolation, increase it further and control wound infection and keep the energy of wound clean environment
The effect of power, provides a kind of significantly more efficient gel dressing for patient.
After above two key component, the medical recombination chitosan gel of the present invention also includes multiple auxiliary materials, as
Thickening agent, wetting agent etc..
Wherein, thickening agent can be selected from starch, alginic acid and salt thereof, arabic gum, tragakanta, agar, cellulose, carboxylic
Sodium carboxymethylcellulose pyce, hydroxypropyl cellulose, hypromellose, hydroxyethyl cellulose, methylcellulose, carbomer, gelatin, Huang
At least one in virgin rubber, hyaluronic acid, modified starch, sodium polyacrylate, polyvinyl alcohol, Polyethylene Glycol and polyvidone；Moisturizing
Agent can be selected from least one in glycerol, propylene glycol, mannitol, butanediol and sorbitol.Add wetting agent and thickening agent
After, except strengthen gel moisture-keeping function in addition to, the most preferable plasticization so that gel coating on wound after skinfeel
More soft, and the tight sense of wound will not be produced after gel moisture evaporates, comfortableness is good.
Additionally, the medical recombination chitosan gel of the present invention can also include pH adjusting agent, wherein, the use of pH adjusting agent
Amount is for adjusting the pH value of medical recombination chitosan gel to 2～11, thus reduces gel dressing and thorn during Wound contact
Swash property.Wherein, pH adjusting agent can be acid or alkali, and acid can be selected from hydrochloric acid, acetic acid, sulphuric acid, boric acid, lactic acid, citric acid, winestone
At least one in acid and malic acid, alkali can be selected from sodium hydroxide, sodium bicarbonate, sodium carbonate, sodium citrate and triethanolamine
In at least one.
According to the present invention, the type of service of described medical recombination chitosan gel include amorphous gel, lamellar gel and
Spray form gel, can think amorphous gel, lamellar gel or spray form gel.Wherein, preferably amorphous gel, its
Can be applied not only to epidermal wound, apply also for deep wounds, cave type wound etc., the wound and favourable of preferably fitting
Healing in wound.Certainly, lamellar gel and spray form gel also have moisture-keeping function clearly, using the teaching of the invention it is possible to provide wet union
Environment and autolyzed debridement effect.Further, the medical recombination chitosan gel of the present invention is applicable to acute otch (such as: all kinds of handss
Art otch, little debridement surgical, little skin injury and wiping are dampened) and chronic wound is (such as: decubital ulcer, vascular lesions ulcer, bone marrow
Inflammation, tophus ulceration etc.), i.e. it is not only suitable for acute otch, is also applied for chronic wound.But the invention is not restricted to this.
Correspondingly, in order to prepare the medical recombination chitosan gel of multi-form, different preparation technologies can be mated,
The present invention can use gel dressing preparation technology commonly used in the art prepare.
Such as, when preparing amorphous gel, can be first by molten to chitosan family macromolecule material and the adjuvant of recipe quantity
And it is stirred continuously until the swelling gel that uniformly obtains in purified water under optimum conditions, then the antibacterials of recipe quantity are added
In described gel and stir, utilize pH adjusting agent regulation product pH value to preset range afterwards, by gained gel subpackage, go out
Bacterium i.e. obtains amorphous gel.
The most such as, when preparing lamellar gel, can first chitosan family macromolecule material and the adjuvant of recipe quantity be dissolved in
In purified water and it is stirred continuously until the swelling gel that uniformly obtains under optimum conditions, then the antibacterials of recipe quantity are added institute
State in gel and stir, standing and defoaming, utilize afterwards pH adjusting agent regulation product pH value to preset range, by gained gel
Sialorrhea molding on back lining materials, drying and forming-film, combination protecting film, cutting, subpackage, sterilizing, obtain lamellar gel.
The most such as, when preparing spray form gel, first the antibacterials of recipe quantity can be added adjuvant stirring until molten
Solve, then add purified water and after mixing, add chitosan family macromolecule material, be stirred continuously until formation under optimum conditions solidifying
Glue, utilizes pH adjusting agent regulation product pH value to preset range and to add purified water to full dose afterwards, and after sterilizing, subpackage i.e. obtains spray
Vaporific gel；Can also be first by the chitosan family macromolecule material of recipe quantity with adjuvant is dissolved in purified water and under optimum conditions
It is stirred continuously until the swelling gel that uniformly obtains, then the antibacterials of recipe quantity is added to described gel and mix homogeneously,
PH adjusting agent regulation product pH value is utilized to preset range and to add purified water to full dose, subpackage after standing and defoaming, sterilizing afterwards
Obtain spray form gel.
Should be understood that above-mentioned embodiment that the present invention describes in detail and the example below are merely to illustrate the present invention rather than restriction
The scope of the present invention, some nonessential improvement and adjustment that those skilled in the art makes according to the foregoing of the present invention
Belong to protection scope of the present invention.The parameter etc. that following example is concrete is the most only an example in OK range, i.e. ability
Field technique personnel can be selected in the range of being done suitably by explanation herein, and does not really wants to be defined in the concrete number of hereafter example
Value.
Below in conjunction with embodiment, the medical recombination chitosan gel containing antibacterials of the present invention is described further.
Embodiment 1:
The prescription of the medical recombination chitosan gel amorphous gel containing antibacterials:
Preparation method: (1) weighs the glacial acetic acid of recipe quantity, adds purified water and is configured to the glacial acetic acid solution of 1%, owing to shell gathers
Sugar is only capable of being dissolved in weak acid, so utilizing pH adjusting agent acetic acid to be configured to glacial acetic acid solution to dissolve chitosan；(2) shell is gathered
Sugar, hypromellose and glycerol, join in the glacial acetic acid of above-mentioned 1%, place swelling overnight；(3) by gentamycin sulfate
Dissolve by appropriate purified water, join in the gel that step (2) is formed, be uniformly mixed；(4) will with sodium hydrate aqueous solution
The pH value of gel is adjusted to 4～7, supplies the purified water of surplus, sterilizing, packs and i.e. obtains medical recombination chitosan gel.
Prepared gel is applicable to acute otch, and (all kinds of operative incisions, little debridement surgical, little skin injury and wiping are frustrated
Wound), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.), it is possible to provide Moist healing environment, suppression
Play, while scar hyperplasia, autolyzed debridement, formation physical isolation, the effect controlling to infect.
Embodiment 2:
The prescription of the medical recombination chitosan gel amorphous gel containing antibacterials:
Preparation method: (1) weighs the carboxymethyl chitosan of recipe quantity, sodium carboxymethyl cellulose and glycerol, joins appropriate
In purified water, stirring mixing, stand overnight；(2) the Crow phosphoric acid gentamycin weighing recipe quantity joins what step (1) was formed
In gel, it is uniformly mixed；(3) with hydrochloric acid/sodium hydroxide, the pH value of gel is adjusted to 4～7, supplies purified water to 100 parts,
Standing and defoaming, sterilizing, packs and i.e. obtains medical recombination chitosan gel.
Prepared gel is applicable to acute otch (all kinds of operative incisions, little debridement surgical, little skin injury and wiping
Dampen), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.), it is possible to provide moist wounds healing ring
Border, assist wound healing play the effect controlling to infect simultaneously.
Embodiment 3:
The prescription of the medical recombination chitosan gel amorphous gel containing antibacterials:
Preparation method: (1) weighs the carboxymethyl chitosan of recipe quantity, sodium alginate and propylene glycol, joins in purified water,
Place swelling overnight；(2) Clindamycin Hydrochloride is dissolved by appropriate purified water, join in the gel that step (1) is formed, stirring
Mix homogeneously；(3) with hydrochloric acid/sodium hydrate aqueous solution, the pH value of gel is adjusted to 7～9, supplies the purified water of surplus, sterilizing,
Pack and i.e. obtain medical recombination chitosan gel.
Prepared gel is applicable to acute otch (all kinds of operative incisions, little debridement surgical, little skin injury and wiping
Dampen), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.), it is possible to provide moist wounds healing ring
Border, assist wound healing play the effect controlling to infect simultaneously.
Embodiment 4:
The prescription of the medical amorphous gel of recombination chitosan gel containing antibacterials:
Preparation technology is as follows: (1) weighs the chitosan hydrochlorate of recipe quantity, gelatin and propylene glycol and is placed in appropriate purified water
In, stirring mixing, stand overnight；(2) the amikacin sulfate suitable quantity of water weighing recipe quantity is dissolved, and joins step (1) shape
In the gel become, it is uniformly mixed；(3) with sodium hydroxide/hydrochloric acid, the pH value of gel is adjusted to 4～7, supplies the purification of surplus
Water, standing and defoaming, sterilizing, pack and i.e. obtain medical recombination chitosan gel.
Prepared dressing is applicable to acute otch, and (all kinds of operative incisions, little debridement surgical, little skin injury and wiping are frustrated
Wound), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.), during use, dressing is coated wound,
Can be that wound provides the healing of Moist healing environment, assist wound play prevention simultaneously and control infection effect.
Embodiment 5:
The prescription of the medical recombination chitosan gel spray shape gel containing antibacterials:
Preparation method: (1) weighs the carboxymethyl chitosan of recipe quantity, polyvinyl alcohol and glycerol, joins appropriate purified water
In, stirring mixing, stand overnight；(2) the gentamycin sulfate suitable quantity of water weighing recipe quantity is dissolved, and joins step (1) shape
In the gel become, it is uniformly mixed；(3) with hydrochloric acid/sodium hydroxide, the pH value of gel is adjusted to 4～7, supplies purified water, quiet
Put deaeration, sterilizing, pack and i.e. obtain medical recombination chitosan gel.
Prepared dressing is applicable to acute otch, and (all kinds of operative incisions, little debridement surgical, little skin injury and wiping are frustrated
Wound), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.), during use directly by liquid dressing spray
On wound, it is to avoid the misery of patient when smearing, also can alleviate infection risk and play antibacterial action simultaneously.
Embodiment 6:
The prescription of the medical recombination chitosan gel spray shape gel containing antibacterials:
Preparation method: (1) weighs the glacial acetic acid of recipe quantity, adds purified water and is configured to glacial acetic acid aqueous solution, due to chitosan
It is only capable of being dissolved in weak acid, so utilizing pH adjusting agent acetic acid to be configured to glacial acetic acid solution to dissolve chitosan；(2) prescription is weighed
Amount chitosan and glycerol, join in (1) gained solution, stirring mixing, stands overnight；(3) the sulphuric acid celebrating weighing recipe quantity is big
Mycin joins in the gel that step (2) is formed, and is uniformly mixed；(4) supply purified water to full dose, standing and defoaming, go out
Bacterium, packing and i.e. obtain medical recombination chitosan gel, gained pH of latex gel is between 4～7.
Prepared dressing is applicable to acute otch (all kinds of operative incisions, little debridement surgical, little skin injury and wiping
Dampen), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.), directly by liquid dressing during use
It is sprayed on wound, it is to avoid the misery of patient when smearing, also can alleviate infection risk and play antibacterial action simultaneously.
Embodiment 7:
The prescription of the medical recombination chitosan gel lamellar gel containing antibacterials:
Preparation method: (1) weighs the chitosan quaternary ammonium salt of recipe quantity, hydroxyethyl cellulose and mannitol and is placed in appropriate purification
In water, stirring mixing, stand overnight；(2) the gentamycin sulfate suitable quantity of water weighing recipe quantity is dissolved, and joins step (1)
In the gel formed, it is uniformly mixed；(3) with sodium hydroxide/hydrochloric acid, the pH value of gel is adjusted to 5～8, standing and defoaming；
(4) by the sialorrhea molding on back lining materials of gained gel, drying and forming-film, combination protecting film also cuts, packs, and sterilizing obtains doctor
Use recombination chitosan gel.
Prepared dressing is applicable to acute otch, and (all kinds of operative incisions, little debridement surgical, little skin injury and wiping are frustrated
Wound), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.), during use, dressing is affixed on wound, can
There is provided the healing of Moist healing environment, assist wound to play for wound simultaneously and control infection effect.Gel film is transparent simultaneously, it is simple to see
Examine the healing state of wound.
Embodiment 8:
The prescription of the medical recombination chitosan gel lamellar gel containing antibacterials:
Preparation method: (1) weighs the hydroxypropyl chitosan of recipe quantity, hypromellose, Polyethylene Glycol and glycerol and is placed in
In appropriate purified water, stirring mixing, stand overnight；(2) the western acid in husband ground weighing recipe quantity joins the gel that step (1) is formed
In, it is uniformly mixed；(3) with sodium hydroxide or hydrochloric acid, the pH value of gel is adjusted to 4～6, standing and defoaming；(4) by gained
Gel is sialorrhea molding on back lining materials, drying and forming-film, combination protecting film and cut, pack, the medical Composite Shell of sterilizing, thus obtaining the product gathers
Sugar gel.
Prepared gel is applicable to acute otch, and (all kinds of operative incisions, little debridement surgical, little skin injury and wiping are frustrated
Wound), chronic wound (decubital ulcer, vascular lesions ulcer, osteomyelitis, tophus ulceration etc.).During use, dressing is affixed on wound, can
There is provided the healing of Moist healing environment, assist wound to play for wound simultaneously and control infection effect.Gel film is transparent simultaneously, it is simple to see
Examine the healing state of wound.
In sum, the present invention provides one have prevention and control to infect, provide wet for skin and mucosa injury patient
Property healing environment, autolyzed debridement, control scar hyperplasia and the dressing of physical isolation effect, antibacterials contained therein rise
To the effect controlling infection.
The invention is not limited in aforesaid detailed description of the invention.The present invention expands to any disclose in this manual
New feature or any new combination, and the arbitrary new method that discloses or the step of process or any new combination.
Claims (10)
1. the medical recombination chitosan gel containing antibacterials, it is characterised in that in parts by weight, described medical compound
Chitosan gel rubber includes following components: 0.5～10 part of chitosan family macromolecule material, 0.05～2 part of antibacterials, 0～10 part
Thickening agent, 1～25 part of wetting agent and 53～98.45 parts of purified water.
Medical recombination chitosan gel containing antibacterials the most according to claim 1, it is characterised in that with weight portion
Meter, described medical recombination chitosan gel includes following components: 1.5～6 parts of chitosan family macromolecule materials, 0.05～1 part resist
Bacterium medicine, 0～5 part of thickening agent, 4～15 parts of wetting agents and 73～94.45 parts of purified water.
Medical recombination chitosan gel containing antibacterials the most according to claim 1 and 2, it is characterised in that described
Medical recombination chitosan gel also includes pH adjusting agent, and wherein, the usage amount of described pH adjusting agent is described medical for adjusting
The pH value of recombination chitosan gel is to 2～11.
Medical recombination chitosan gel containing antibacterials the most according to claim 1 and 2, it is characterised in that described
At least one in the derivant of chitosan, the salt of chitosan and chitosan of chitosan family macromolecule material；Described shell gathers
The derivant of sugar is selected from carboxymethyl chitosan, isobutyl-chitosan, hydroxypropyl chitosan and hyaluronic acid-like chitosan extremely
Few one；The salt of described chitosan selected from chitosan quaternary ammonium salt, chitosan hydrochlorate, chitosan lactate, chitosan acetate,
Chitosan tartarate, Chitosan Sulfate, glutamate, Chitosan citrate., chitosan succinate and shell
At least one in polysaccharide acetylsalicylate；The molecular weight of described chitosan family macromolecule material is 1000～1000000.
Medical recombination chitosan gel containing antibacterials the most according to claim 1 and 2, it is characterised in that described
Antibacterials are dispersed or dissolved in described medical recombination chitosan gel, wherein, described antibacterials selected from gentamycin or
Its salt, neomycin or its salt, amikacin or its salt, fusidic acid or its salt, kanamycin or its salt, policresulen, not
At least one in Luo Xing, mafenide or its salt and clindamycin or its salt.
Medical recombination chitosan gel containing antibacterials the most according to claim 1 and 2, it is characterised in that described
Thickening agent is selected from starch, alginic acid and salt, arabic gum, tragakanta, agar, cellulose, sodium carboxymethyl cellulose, hydroxypropyl
Base cellulose, hypromellose, hydroxyethyl cellulose, methylcellulose, carbomer, gelatin, xanthan gum, hyaluronic acid, change
At least one in property starch, sodium polyacrylate, polyvinyl alcohol, Polyethylene Glycol and polyvidone.
Medical recombination chitosan gel containing antibacterials the most according to claim 1 and 2, it is characterised in that described
At least one in glycerol, propylene glycol, mannitol, butanediol and sorbitol of wetting agent.
Medical recombination chitosan gel containing antibacterials the most according to claim 3, it is characterised in that described pH adjusts
Joint agent is acid or alkali, and wherein, acid is selected from hydrochloric acid, acetic acid, sulphuric acid, boric acid, lactic acid, citric acid, tartaric acid and malic acid extremely
Few one, at least one in sodium hydroxide, sodium carbonate, sodium bicarbonate, sodium citrate and triethanolamine of alkali.
Medical recombination chitosan gel containing antibacterials the most according to claim 1 and 2, it is characterised in that described
The type of service of medical recombination chitosan gel is amorphous gel, lamellar gel or spray form gel.
Medical recombination chitosan gel containing antibacterials the most according to claim 1 and 2, it is characterised in that described
Medical recombination chitosan gel is applicable to acute otch and chronic wound.
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