CN101278896A - Chitosan nano silver gel agent and uses thereof - Google Patents
Chitosan nano silver gel agent and uses thereof Download PDFInfo
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Abstract
The invention relates to a chitosan nano silver gelata used for treating an inflammation in a lower genital tract, cervicitis and cervical erosion of female and empyrosis, scalding, bedsore infection and other skin inflammations such as tinea manus and pedes, and various wound infections, etc. The medicinal raw materials of the chitosan nano silver gelata of the invention are the nano silver and chitosan polymer in respective therapy dose; the nano silver is the nano silver powder or the nano silver colloid; the chitosan polymer is the chitosan and the chitin and one or more than one derivative of the chitosan and the chitin. The product of the invention has the advantages of high efficiency and being nonpoisonous, and has an extremely strong antibacterial action and an excellent therapeutic effect; compared with other nano silver gelata, the chitosan nano silver gelata of the invention has the advantages of perfect sterilizing effect, long-lasting effect and tissue repair function.
Description
Technical field
The present invention relates to a kind of chitosan nano silver gel agent, be used for treating urogenital tract infection under the women, cervicitis, cervical erosion and burn, scald, decubital ulcer infection and other scytitiss such as tinea manus and pedis, various traumatic infections etc.
Background technology
Urogenital tract infection under the women, cervicitis, cervical erosion sickness rate are higher, are the commonly encountered diseases in the gynaecopathia.At present, the treatment product is more on the market, but therapeutic effect is undesirable, and relapse rate is higher.
The incidence rate of burn and scald, decubital ulcer patient infection is higher, and more use antibiotic easily produces drug resistance, is difficult to disease controlling.
The scytitis kind is more, the big and recurrence easily of treatment difficulty, and a lot of scytitiss do not have the specific antibacterial medicine.
Silver has intensive bactericidal effect, can kill 600 various bacteria, and can not produce drug resistance.Its sterilization mechanism is that silver-colored the combination with sulfydryl enzyme in the bacterial body loses activity it, makes antibacterial death; The Peptidoglycan reaction that exposes on silver and the bacteria cell wall forms the reversibility complex, makes them not advance cell to oxygen (energy) transhipment, stops the activity of pathogenic bacteria, causes its death; The DNA combination of silver and pathogenic bacterium causes the dna structure degeneration, and reproducible does not make the pathogenic bacterium inactivation.
Chitosan also has bactericidal action, and under acid condition, the amino in the chitosan molecule has positive charge, becomes NH
3+Absorption has the antibacterial of negative charge, make the negative charge skewness on bacteria cell wall and the cell membrane, synthesizing of interference cell wall, break the synthetic and dissolution equilibrium of cell wall under naturalness, make cell wall trend towards dissolving, cell membrane is not because of bearing the osmotic pressure deformation fracture, content such as water, the protein etc. of cell ooze out, and bacterolysis take place and death.
At the disclosed patent of the 2005.9.28 of the China Intellectual Property Office " nano silver antimicrobial gel of treatment women ' s genital tract infection, preparation method and application " in (publication number CN1672689), disclose and used nanometer silver as antibacterial, carbomer etc. are as the antibacterial gel of figuration material.Used excipient is the artificial-synthetic compound, and does not have antibacterial action, does not have the tissue repair function.
The disclosed patent of the 2005.12.21 of China Intellectual Property Office " Chitosangynaecologicsuppository suppository and preparation method thereof " (CN1709278) in, a kind of chitosan suppository is disclosed, mainly be that chitosan is placed in the polyoxyethylene monostearate of fusing, stir, then mixed liquor is poured in the grinding tool, be refrigerated to 8 degree then with compacted under.This suppository uses as the gynaecologic antibiotic agent, does not have nanometer silver in this suppository, and antibacterial effect is not strong.And suppository has limited route of administration, can not be used for the treatment of dermatosis, burn and scald etc.
Summary of the invention
Purpose of the present invention provides a kind of chitosan nano silver gel agent, has good anti-bacterial effect, and duration of efficacy is long, does not have drug resistance, and tissue is had repair function.
Another object of the present invention is to provide above-mentioned chitosan nano silver gel agent using on urogenital tract infection, cervicitis, cervical erosion, burn, scald, ulcer, decubital ulcer infection or the scytitis medicine under the preparation treatment women.
The present invention realizes by following measure:
Chitosan nano silver gel agent of the present invention, its medicinal raw material is the nanometer silver and the chitosan base polymer of survival dose, described nanometer silver is nanometer silver powder or nano silver colloid, and described chitosan base polymer is one or more of chitosan and chitin and derivant thereof.
The chitosan nano silver gel of the invention described above, its adjuvant includes gel, wetting agent and diluent, and the hydrotropy acid that is used to dissolve the chitosan base polymer.
The chitosan nano silver gel of the invention described above, described gel are one or more of carbomer, Polycarbophil, cellulose and derivant thereof and Polyethylene Glycol; Described wetting agent is one or more of glycerol, propylene glycol and sorbitol; Described hydrotropy acid is sulphuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, hydrochloric acid, 1,2,3, one or more of 4-BTCA (BTCA) and citric acid (CA).
The chitosan nano silver gel of the invention described above, described nanometer silver weight content is 1ppm-1000,000ppm is preferably 10ppm-2000ppm nanometer silver particle diameter between 1-100nm; Described chitosan base polymer concentration is 0.1mg-990mg/g, is preferably 10mg-600mg/g.
The chitosan nano silver gel of the invention described above, the dispersant of described nano silver colloid are one or more of Polyethylene Glycol, cellulose and derivant thereof, polyvinylpyrrolidone and derivant thereof, polyamide and derivant thereof, clay, collagen protein and pectin.
The present invention also provides a kind of above-mentioned chitosan nano silver gel using on urogenital tract infection, cervicitis, cervical erosion, burn, scald, ulcer, decubital ulcer infection or the scytitis medicine under the preparation treatment women.
In the gel of the present invention, described chitosan base polymer is chitosan and chitin and derivant thereof, and the shell, insecticide crust, fungus, the fly larvae shell that derive from shrimp, Eriocheir sinensis are medium, but it is unrestricted to originate.Chitin, chitosan can have other titles.Chitosan is the deacetylation derivative of chitin, and deacetylation position, degree can be different, but are commonly referred to as chitosan.
In the chitosan nano silver gel agent of the present invention, the cross-linking agent that chitosan can crosslinked production take place with chitin, chitin derivativ and their catabolite, with other chemical compounds replaces, as chitosan and cross-linking of starch thing etc., but be not limited to starch with crosslinked other chemical compounds such as chitosan; Chitosan also can use the cross-linking products between chitin, chitin derivativ and their catabolite to replace.Cross-linking products can be crosslinked with physical method, and also available cross-linking agent is crosslinked, and when using cross-linking agent, the cross-linking agent kind is unrestricted.During cross-linking reaction, can also use catalyst, catalyst type is unrestricted.
In the chitosan nano silver gel agent of the present invention, this gel has certain viscosity, and the viscosity of gel is greater than 50mPaS.
Preparation method of the present invention:
Chitosan nano silver gel agent of the present invention, its preparation method is: chitosan is dissolved in the dilute acid soln, fully add in the agitator after the swelling, nanometer silver (powdery or colloidal sol shape) is added in the agitator, adding diluent makes nanometer silver, chitosan content reach requirement, fully stir and make nanometer silver chitosan mix homogeneously, form gel; Promptly form chitosan nano silver gel of the present invention, packing gets final product then.Another kind of preparation method is: chitosan, dilute acid soln, nanometer silver (powdery or colloidal sol shape), diluent are added in the agitator, after fully stirring makes the abundant swelling of chitosan, form gel; Promptly form chitosan nano silver gel of the present invention, packing then.
Can be contained in after gel makes in the gel device, be made of for gel device sleeve pipe, boosting bar, cannula tip has protective cap.The gel device external form is more elongated, the top is mellow and full, is fit to vagina administration.Gel is pre-loaded in the sleeve pipe, with push rod and sleeve combination, by push rod the chitosan nano silver gel is directly pushed intravaginal during use.
Also can pack into after gel makes in the plastic-aluminum flexible pipe, be used to burn, scald, decubital ulcer infection, the treatment of other scytitiss, various traumatic infection treatments etc.
Antibiotic mechanism of the present invention has following several reasons:
1. chitosan molecule is under acid condition, and its amino becomes positively charged-NH3
+, adsorb electronegative cell wall, make chitosan be adsorbed on surface of cell membrane and form one deck polymeric membrane, changed the selection permeability of cell membrane, stop nutrient substance to intracellular transportation, cause Cytoplasm loss, cell plasmolysis, thereby play the bacteriostasis and sterilization effect.
2. chitosan has anionic Cytoplasm by infiltrating in the cyton in the adherent cell body, and the normal physiological activity of flocculation upset cell takes place, thus kill bacteria.
3. silver combines with sulfydryl enzyme in the microorganism and makes latter's inactivation, and the energy metabolism and the cell wall of blocking-up microorganism are synthetic, play the effect of kill bacteria, virus and eukaryotic microorganisms.
4. the Peptidoglycan reaction that exposes on silver and the bacteria cell wall forms the reversibility complex, makes them not advance cell to oxygen (energy) transhipment, stops the activity of pathogenic bacteria, causes its death.
5. silver and the DNA combinations of pathogenic bacterium forms cross-linkedly with the bonded silver ion of DNA base each other, causes the dna structure degeneration, suppresses it and duplicates, and makes the pathogenic bacterium inactivation.
Product of the present invention also has the tissue repair function, and silver can promote epithelium regeneration and tissue repair, thereby promotes wound and rotten to the corn healing.Chitosan has activating cell function, immune cell activated, can induce special cells in injured human body, promotes wound repair, increases the wound healing ability, and product of the present invention does not have drug resistance.。
Product of the present invention is used for the treatment of the curative effect that urogenital tract infection under the women, cervicitis, cervical erosion etc. have remarkable excellence.Gel of the present invention can pass through the direct administration of vagina, and the nanometer-level silver particle diameter is little, and specific surface area is big, has increased and the pathogenic bacteria touch opportunity, has strengthened bactericidal effect.Chitosan is by its charged NH3
+Combine with the anion of bacteria cell wall, kill gram negative bacteria, positive bacteria, and chitosan repair function in a organized way, can promote the healing of wound, repair rotten to the corn face.The nanometer silver broad-spectrum antiseptic all has intensive inhibition, killing action to gram negative bacteria, gram positive bacteria, fungus, infusorian etc.Product of the present invention also has slow releasing function, and chitosan is a macromolecular polysaccharide, and nanometer silver is had slow-release function, can prolong the release of nanometer silver, and therapeutic effect is more remarkable.Gel avirulence of the present invention, no anaphylaxis, nonirritant, and have the tissue repair function, can promote the healing of rotten to the corn face.So product of the present invention is rapid-action, therapeutic effect good, do not have toxic and side effects, treat longer duration, can strengthen tissue repairing ability, do not influence the vagina normal flora and acid-base value, bactericidal action are not influenced by pH value.
Product of the present invention also can be treated various infection except urogenital tract infection under the treatment women, as skin infection etc.This product also can be used for cosmetics, and chitosan generates cation in rare weak acid, forms polyelectrolyte, has very high moisture absorption and moisture-keeping function, and also has antibacterial action, and skin is not had zest.Acarid often causes the skin of face redness, and a small amount of nanometer silver can be killed pathogen by skin permeation, the reaction that reduces inflammation, the chitosan reparation skin of can preserving moisture.Product of the present invention all has intensive inhibition, killing action to the inflammation that antibacterial, fungus, virus or parasite etc. cause.
Clinical trial certificate, product of the present invention is efficient, nontoxic, has extremely strong antibacterial action and excellent therapeutic effect, compares with other nano silver gel agents, and bactericidal effect is strong, effect is lasting and have the tissue repair function.
Description of drawings
Fig. 1 is boosting bar and telescopic split structural representation to gel device.
Fig. 2 is to the structural representation after the assembling of gel device.
Among the figure, 1 sleeve pipe, 2 boosting bars, 3 plugs, 4 gels, 5 protective caps.
The specific embodiment
Embodiment 1: the manufacture method of chitosan nano silver gel agent
The self-control nanometer silver adopts polyvinylpyrrolidonesolution solution to be dispersed into colloid, content of nanometer silver 40000ppm,
Nano silver colloid: 5g.
Chitosan: 10g
Carbomer: 3g
Ethylene glycol: 2ml
Distilled water: 79g
Acetic acid: 1ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 2000ppm; The concentration of chitosan is 100mg/g.Divide after preparation is finished and be filled to in the gel device or in the plastic-aluminum pipe.
The chitosan nano silver gel of above-mentioned preparation can be used for the treatment of urogenital tract infection under the women, cervicitis, cervical erosion, burn, scald, ulcer, decubital ulcer infection or scytitis.
The detailed directions and the consumption of diseases such as treatment cervicitis are: as depicted in figs. 1 and 2, be made of for gel device sleeve pipe 1, boosting bar 2, there is a plug 3 at the middle part of sleeve pipe 1, and the plug front sealing has gel 4, and there is protective cap 5 on telescopic top.The gel device external form is more elongated, the top is mellow and full, is fit to vagina administration.Gel is pre-loaded in the sleeve pipe, with push rod 2 and sleeve pipe 1 combination, by push rod the chitosan nano silver gel is directly pushed intravaginal during use.Each consumption 3g, every day 1 time.
The detailed directions and the consumption of diseases such as treatment burn, scald are: gel is applied to the affected part, every day 1 time.
The manufacture method of embodiment 2 chitosan nano silver gel agents
Self-control nanometer silver powder: 1mg
Chitosan: 60g
Glycerol: 2g
Carbomer: 3g
Distilled water: 32g
Acetic acid: 3ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 10ppm; Chitosan concentration is 600mg/g.Divide after preparation is finished and be filled to in the gel device or in the plastic-aluminum pipe.
Usage and consumption are with embodiment 1.
The manufacture method of embodiment 3 chitosan nano silver gel agents
Self-control nanometer silver powder: 5g
Chitin: 1g
Polyethylene Glycol: 3g
Distilled water: 91.5g
Phosphoric acid: 0.5ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 50000ppm; Chitosan concentration is 10mg/g.Divide after preparation is finished and be filled to in the gel device or in the plastic-aluminum pipe.
Usage and consumption are with embodiment 1.
Embodiment 4: the manufacture method of chitosan nano silver gel agent
Self-control nanometer silver: 20mg
Carboxymethyl chitosan: 80g
Carbomer: 2g
Ethylene glycol: 1ml
Distilled water: 13g
Hydrochloric acid: 4ml
Place agitator fully to stir above-mentioned raw materials, get chitosan nano silver gel agent, content of nanometer silver 200ppm; The concentration of carboxymethyl chitosan is 800mg/g.Divide after preparation is finished and be filled to in the gel device or in the plastic-aluminum pipe.
Usage and consumption are with embodiment 1.
Test case 1
Product to embodiment 1-4 carries out the in-vitro antibacterial experiment, and experimental result is as shown in table 1.
The in-vitro antibacterial experimental result of table 1 embodiment 1-4
Test case 2
Product to embodiment 1-4 has carried out the experiment of nanometer silver slow release according to the method among two appendix XD of Pharmacopoeia of the People's Republic of China version in 2005, and the result is as shown in table 2.
The external slow release experiment of table 2 embodiment 1-4 product
Test case 3
Embodiment 1-4 product promotes cell proliferation experiment, and the result is as shown in table 3.
The cell proliferation experiment of table 3 embodiment 1-4 product
Claims (7)
1, a kind of chitosan nano silver gel agent, it is characterized in that: its medicinal raw material is the nanometer silver and the chitosan base polymer of survival dose, described nanometer silver is nanometer silver powder or nano silver colloid, and described chitosan base polymer is one or more of chitosan and chitin and derivant thereof.
2, chitosan nano silver gel according to claim 1, it is characterized in that: its adjuvant includes gel, wetting agent and diluent, and the hydrotropy acid that is used to dissolve the chitosan base polymer.
3, chitosan nano silver gel according to claim 2 is characterized in that: described gel is one or more of carbomer, Polycarbophil, cellulose and derivant thereof and Polyethylene Glycol; Described wetting agent is one or more of glycerol, propylene glycol and sorbitol; Described hydrotropy acid is sulphuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, hydrochloric acid, 1,2,3, one or more of 4-BTCA and citric acid.
4, chitosan nano silver gel according to claim 1 and 2 is characterized in that: described nanometer silver weight content is 1ppm-1000,000ppm, and the nanometer silver particle diameter is between 1-100nm; Described chitosan base polymer concentration is 0.1mg-990mg/g.
5, chitosan nano silver gel according to claim 4 is characterized in that: described nanometer silver weight content is 10ppm-2000ppm, and the nanometer silver particle diameter is between 1-100nm; Described chitosan base polymer concentration is 10mg-600mg/g.
6, chitosan nano silver gel according to claim 1 and 2 is characterized in that: the dispersant of described nano silver colloid is one or more of Polyethylene Glycol, cellulose and derivant thereof, polyvinylpyrrolidone and derivant thereof, polyamide and derivant thereof, clay, collagen protein and pectin.
7, the described chitosan nano silver gel of a kind of claim 1 is being used on urogenital tract infection, cervicitis, cervical erosion, burn, scald, ulcer, decubital ulcer infection or the scytitis medicine under the preparation treatment women.
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