CN102872160A - Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds - Google Patents
Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds Download PDFInfo
- Publication number
- CN102872160A CN102872160A CN2012104148687A CN201210414868A CN102872160A CN 102872160 A CN102872160 A CN 102872160A CN 2012104148687 A CN2012104148687 A CN 2012104148687A CN 201210414868 A CN201210414868 A CN 201210414868A CN 102872160 A CN102872160 A CN 102872160A
- Authority
- CN
- China
- Prior art keywords
- agent
- silver
- liquid
- nano
- foaming agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds. The nano-silver foaming agent is prepared from antibacterial material nano-silver and chitosan as main components and a solubilizing agent, a wetting agent, a thickening agent, potential of hydrogen (pH) value regulator, a foaming agent and a preservative as auxiliary materials through adding bacteriocidal substance borneol and cool substance menthol crystal. A preparation method for the nano-silver foaming agent comprises the following steps of: evenly mixing all components; then, performing ultrasonic homogenizing for 30 minutes to prepare a solution; then, filling the solution into a pressure bottle; adding a propellant to prepare nano-silver foaming agent finished product (50-100nm) used for sterilizing the wounds of the scalds and burns and the ulcer wounds. The product is good in sterilizing effect, is safe and reliable, is free of skin irritation and can be used for promoting the healing of the wounds. The process is simple and feasible, and the product is convenient to use and remarkable in effect.
Description
Technical field
The present invention relates to a kind of foam for scalding burn, ulcer wound disinfection, be specifically related to a kind ofly take nanometer silver and chitosan as the foam of Fungicidal substance, belong to the medical disinfectant production technical field.
Background technology
Wound is seen everywhere in the life, usually can cause the damage of skin and soft tissue, in case cause, will bring inconvenience to people's live and work, even is threatening human health.In order to make wound not infected, can heal quickly, first will be to the wound disinfection, disinfectant solution commonly used has iodine tincture, ethanol, hydrogen peroxide etc., but these material incentives are larger, should avoid heavy dose of and use, especially suppurative wound, the fat of purulent secretion and wound inside can react with iodine, generates chemical compound and makes its inefficacy.
The anti-microbial property of silver just is widely used in the world of medicine as far back as 16th century, festers as cover the wound prevention with silver strip, is made into gauze parcel skin trauma etc. with filamentary silver.The thirties in 20th century, antibiotic discovery once made people ignore utilization to silver-colored anti-microbial property.Yet, abuse along with chemicalses such as antibiotic, increasing microorganism has produced drug resistance by variation, so that some diseases can't be cured, and nanometer silver is the novel antibacterial product that forms take nanotechnology as foundation development, because quantum effect, small-size effect and have great specific surface area, thereby have the incomparable antibacterial effect of traditional inorganic antiseptic, and safe, render a service lastingly, be a kind ofly to have long-lasting and the weatherability antibacterial.The principle of relevant bactericidal nano-silver effect, most scholars think, ultra-fine state silver surface is actively large, in water, be Ag+, therefore the bactericidal action of nanometer silver is main relevant with silver ion, can with pheron in the thalline in-the rapid combination of SH, for the key enzyme inactivation, make pathogenic bacterium not energy metabolism and death; Secondly, nanometer silver can be combined and form cross-linked with the DNA of pathogenic base, replaces the hydrogen bond between the adjacent nitrogen in purine and the pyrimidine, makes the DNA degeneration and reproducible not, causes the pathogenic bacterium inactivation.The atomic arrangement surface of nanometer silver is " Jie's attitude " between solid and molecule, and the extremely strong Silver nanoparticles of this activity possesses superpower antibacterial ability, but the pathogenic microorganism such as killing bacteria, fungus, mycoplasma, chlamydia.In addition, nanometer silver is again non-antibiotics antibacterial, without any antibacterial silver is produced drug resistance at present, have no adverse reaction, do not produce cross infection, as seen, nanometer silver except wide spectrum, bacteriostasis and sterilization effect are strong, can also promote tissue repair and regeneration, safety, toxic and side effects are little.
Nanometer silver is also more and more for the research of sterilization at present, and CN101305736 discloses a kind of preparation method of nano-silver sterilization liquid, and nanometer silver powder is added to the water, and makes bactericidal liquid; CN1827173A discloses a kind of chelated nano silver disinfection solution and its production and use, and product is mainly used in the sterilization of public area; CN1685830A discloses a kind of nano-silver antimicrobial powder and preparation method, product is mainly used in the fields such as china sanitary ware, domestic ceramics, architectural pottery, effect is remarkable, it all is to be used in above the dressing that but nanometer silver is used for the present major part of research of wound sterilization, can reach the effect of sterilization and promotion wound healing, also not have nano silver disinfectant to be directly used in the report of wound sterilization at present.
Scald, ulcer treatment is main is to prevent that antibacterial from infecting, old ulcer does not particularly prolongedly heal, wound infection antibacterial, and produce drug resistance, antibiotics is to its inefficacy.The present invention utilizes the synergism of chitosan and nanometer silver to develop a kind of foam that can be used for scalding burn, ulcer wound disinfection, because chitosan is a kind of have good biocompatibility and biodegradable macromolecular polysaccharide, nontoxic to human body, can promote wound healing and tissue reconstruction, the product that combined effect makes with nanometer silver is kill bacteria directly, and also can form network structure in wound surface, form barrier one, antibacterial is killed it in absorption, not only bactericidal effect is good, and cost is low, and is easy to use.
Summary of the invention
The purpose of this invention is to provide a kind of nano silver foam agent, can be used for scalding burn, ulcer wound disinfection.
Another object of the present invention provides a kind of preparation method of nano silver foam agent.
For realizing the purpose of foregoing invention, the technical scheme that the present invention takes is as follows:
A kind of foam for scalding burn, ulcer wound disinfection, this whipped cream is comprised of drug delivery system and propellant, and the content of each component is:
Nanometer silver sol solution 50 ~ 150ppm
Chitosan 5 ~ 10%
Solubilizing agent 0.1 ~ 1.0%
Wetting agent 0.1 ~ 0.5%
Thickening agent 0.1 ~ 0.5%
Antiseptic 0.1 ~ 1%
Foaming agent 1 ~ 5%
Fungicidal substance 0.5 ~ 1%
Refrigerant material 0.5 ~ 1%
PH adjusting agent is an amount of
Propellant 10-20%
Deionized water is supplied 100g
Wherein, described nanometer silver sol solution is medical solution, its nanometer silver particle diameter 25 ~ 50nm scope; The chitosan molecule amount is distributed in 2000 ~ 5000, and deacetylation is more than 95%.
Described solubilizing agent is mixture (4:1) or the poloxamer of tween 80, Arlacel-80, Tween 80 and sorbester p17; Wetting agent is glycerol; Thickening agent is PVP polyvinyl pyrrolidone K30(C-934), carbomer, microcrystalline Cellulose MCC, sodium carboxymethyl cellulose (CMC-Na), hypromellose (HPMC), chitosan or polyoxyethylene-polyoxypropylene copolymer, wherein first-selected carbomer and hypromellose; Antiseptic is methyl hydroxybenzoate or ethyl hydroxybenzoate; Foaming agent is sodium lauryl sulphate (K-12); Fungicidal substance is Borneolum Syntheticum; Refrigerant material is Mentholum; The pH value regulator is triethanolamine, and the pH value of solution is adjusted to 6 ~ 7, and propellant is iso-butane, isopropyl alkane or hydrogen fluorohydrocarbon (HFC-134a).
A kind of preparation method of nano silver foam agent comprises the steps:
(1) take by weighing an amount of thickening agent, be dissolved in the deionized water, fully swelling is 24 hours, makes stream shape liquid A for subsequent use;
(2) Borneolum Syntheticum mixed with Mentholum mill, miscible after, add solubilizing agent, wetting agent and antiseptic, fully make B liquid after the dissolving for subsequent use;
(3) chitosan is joined in the remaining deionized water, stir, be heated to 80 ℃, after dissolving disperses, add B liquid, mix, get C liquid;
(4) A, C liquid are mixed, add nano silver colloidal sol liquid, regulating pH value with the pH value regulator is 6 ~ 7, adds foaming agent, and ultrasonic homogenizing 30 minutes makes homogeneous solution;
(5) with in the homogeneous solution fill pressure bottle, add propellant (proportionally regulate the foam situation of spraying, regulate the amount that big gun is penetrated agent, general preferred 10-20% ratio of filling), be prepared into nanometer (50-100nm) and scald burn, ulcer wound disinfection sterilization foam.
The invention has the beneficial effects as follows:
(1) this product energy kill bacteria promotes wound healing and tissue reconstruction, and having overcome traditional disinfecting drug stimulates wound, the shortcoming that drug resistance is poor; By the synergism of chitosan and nanometer silver, bactericidal effect is better.
(2) product form is the whipped cream type, and is easy to use, play a role fast and effect remarkable.
(3) by adding chitosan, make that the use amount of nanometer silver is very little can to reach good bactericidal effect, reduced cost, and this technical matters is simple, easy to operate, be fit to large-scale production.
The specific embodiment
Below by example the present invention is described in further details, these examples only are used for illustrating the present invention, do not limit the scope of the invention.
Embodiment 1
The nano silver foam agent is comprised of the component of following weight portion:
The preparation method of nano silver foam agent comprises the steps:
(1) take by weighing carbomer 0.5g, be dissolved among the deionized water 30g, fully swelling is 24 hours, makes stream shape liquid A for subsequent use; (2) the 0.5g Borneolum Syntheticum mixed with the 0.5g Mentholum mill, miscible after, add 0.2g Tween 80,0.1g glycerol, 1g methyl hydroxybenzoate and dissolve fully that to make B liquid for subsequent use; (3) chitosan 5g is joined in the remaining deionized water, stir, be heated to 80 ℃, after dissolving disperses, add B liquid, mix, get C liquid; (4) A, C liquid are mixed, add the nano silver colloidal sol liquid 5g of recipe quantity, regulate pH value to 6 ~ 7 with triethanolamine, add 0.2g foaming agent K12, ultrasonic homogenizing 30 minutes; (5) with 90g in the filled with solution pressure bottle behind the homogenizing, add propellant iso-butane 10g, be prepared into nanometer silver and scald burn, ulcer wound disinfection sterilization foam.
Embodiment 2
The nano silver foam agent is comprised of the component of following weight portion:
The preparation method of nano silver foam agent comprises the steps:
(1) take by weighing carbomer 0.1g, be dissolved among the deionized water 30g, fully swelling is 24 hours, makes stream shape liquid A for subsequent use; (2) the 1.0g Borneolum Syntheticum mixed with the 1.0g Mentholum mill, miscible after, add 0.5g Tween 80,0.5g glycerol, 1g methyl hydroxybenzoate and dissolve fully that to make B liquid for subsequent use; (3) chitosan 10g is joined in the remaining deionized water, stir, be heated to 80 ℃, after dissolving disperses, add B liquid, mix, get C liquid; (4) A, C liquid are mixed, add the nano silver colloidal sol liquid 5g of recipe quantity, regulate pH value to 6 ~ 7 with triethanolamine, add 0.5g foaming agent K12, ultrasonic homogenizing 30 minutes; (5) with 80g in the filled with solution pressure bottle behind the homogenizing, add propellant isopropyl alkane 20g, be prepared into nanometer silver and scald burn, ulcer wound disinfection sterilization foam.
Embodiment 3
The nano silver foam agent is comprised of the component of following weight portion:
The preparation method of nano silver foam agent comprises the steps:
(1) take by weighing carbomer 0.1g, be dissolved among the deionized water 30g, fully swelling is 24 hours, makes stream shape liquid A for subsequent use; (2) the 1.0g Borneolum Syntheticum mixed with the 1.0g Mentholum mill, miscible after, add 0.1g Tween 80,0.5g glycerol, 1g methyl hydroxybenzoate and dissolve fully that to make B liquid for subsequent use; (3) chitosan 10g is joined in the remaining deionized water, stir, be heated to 80 ℃, after dissolving disperses, add B liquid, mix, get C liquid; (4) A, C liquid are mixed, add the nano silver colloidal sol liquid 5g of recipe quantity, regulate pH value to 6 ~ 7 with triethanolamine, add 0.5g foaming agent K12, ultrasonic homogenizing 30 minutes; (5) with 80g in the filled with solution pressure bottle behind the homogenizing, add propellant iso-butane 20g, be prepared into nanometer silver and scald burn, ulcer wound disinfection sterilization foam.
Embodiment 4
The nano silver foam agent is comprised of the component of following weight portion:
The preparation method of nano silver foam agent comprises the steps:
(1) take by weighing carbomer 0.5g, be dissolved among the deionized water 30g, fully swelling is 24 hours, makes stream shape liquid A for subsequent use; (2) the 1.0g Borneolum Syntheticum mixed with the 1.0g Mentholum mill, miscible after, add 2.0g tween 80 and Arlacel-80 mixture, 0.5g glycerol; 0.1g methyl hydroxybenzoate fully dissolves, and to make B liquid for subsequent use; (3) chitosan 10g is joined in the remaining deionized water, stir, be heated to 80 ℃, after dissolving disperses, add B liquid, mix, get C liquid; (4) A, C liquid are mixed, add the nano silver colloidal sol liquid 5g of recipe quantity, regulate pH value to 6 ~ 7 with triethanolamine, add 1.0g foaming agent Tx-10, ultrasonic homogenizing 30 minutes; (5) with 90g in the filled with solution pressure bottle behind the homogenizing, add propellant iso-butane 10g, be prepared into nanometer silver and scald burn, ulcer wound disinfection sterilization foam.
Embodiment 5
The nano silver foam agent is comprised of the component of following weight portion:
The preparation method of nano silver foam agent comprises the steps:
(1) take by weighing hypromellose 0.5g, be dissolved among the deionized water 30g, fully swelling is 24 hours, makes stream shape liquid A for subsequent use; (2) the 1.0g Borneolum Syntheticum mixed with the 1.0g Mentholum mill, miscible after, add 2.0g tween 80,0.5g glycerol, 0.5g methyl hydroxybenzoate and dissolve fully that to make B liquid for subsequent use; (3) chitosan 8g is joined in the remaining deionized water, stir, be heated to 80 ℃, after dissolving disperses, add B liquid, mix, get C liquid; (4) A, C liquid are mixed, add the nano silver colloidal sol liquid 5g of recipe quantity, regulate pH value to 6 ~ 7 with triethanolamine, add 1.0g foaming agent Tx-10, ultrasonic homogenizing 30 minutes; (5) with 90g in the filled with solution pressure bottle behind the homogenizing, add propellant iso-butane 10g, be prepared into nanometer silver and scald burn, ulcer wound disinfection sterilization foam.
Embodiment 6
Nano silver foam agent In Vitro Bacteriostasis experimental result of the present invention sees Table 1 and table 2.
Table 1 foam of the present invention is to the dull and stereotyped bacterium base of staphylococcus aureus fungistatic effect
Data bit antibacterial circle diameter (cm) in the table, diameter is large antibacterial stronger.
Table 2 foam of the present invention is to the bacillus pyocyaneus bactericidal effect
Every group is diluted 100 times, extracorporeal disinfecting experiment expression, and nanometer silver solubility is higher, sterilizes faster.
Claims (4)
1. nano silver foam agent that is used for scalding burn, ulcer wound disinfection, it is characterized in that: this whipped cream is comprised of drug delivery system and propellant, and each component (W/L) is:
Nanometer silver sol solution 50 ~ 150ppm
Chitosan 5 ~ 10%
Solubilizing agent 0.1-1.0%
Wetting agent 0.1 ~ 0.5%
Thickening agent 0.1 ~ 0.5%
Antiseptic 0.5 ~ 1%
Foaming agent 1 ~ 5%
Fungicidal substance 0.5 ~ 1%
Refrigerant material 0.5 ~ 1%
PH adjusting agent is an amount of
Propellant 10-20%
Deionized water is supplied 100g
Described solubilizing agent is mixture or the poloxamer of tween 80, Arlacel-80 or tween 80 and Arlacel-80; Described wetting agent is glycerol; Described thickening agent is PVP polyvinyl pyrrolidone K30(C-934), carbomer, microcrystalline Cellulose MCC, sodium carboxymethyl cellulose (CMC-Na), hypromellose (HPMC), chitosan or polyoxyethylene-polyoxypropylene copolymer; Described antiseptic is methyl hydroxybenzoate or ethyl hydroxybenzoate; Described foaming agent is sodium lauryl sulphate (K-12); Described Fungicidal substance is Borneolum Syntheticum; Described refrigerant material is Mentholum; Described pH value regulator triethanolamine; Described propellant is iso-butane, isopropyl alkane or hydrogen fluorohydrocarbon (HFC-134a).
2. a kind of nano silver foam agent for scalding burn, ulcer wound disinfection according to claim 1, it is characterized in that: described nanometer silver sol solution is medical solution, wherein nanometer silver particle diameter 25 ~ 50nm scope.
3. a kind of nano silver foam agent for scalding burn, ulcer wound disinfection according to claim 1, it is characterized in that: described chitosan molecule amount is distributed in 2000 ~ 5000, and deacetylation is more than 95%.
4. method for the preparation of nano silver foam agent claimed in claim 1 is characterized in that may further comprise the steps:
(1) take by weighing an amount of thickening agent, be dissolved in the deionized water, fully swelling is 24 hours, makes stream shape liquid A for subsequent use;
(2) Borneolum Syntheticum mixed with Mentholum mill, miscible after, add solubilizing agent, wetting agent and antiseptic, fully make B liquid after the dissolving for subsequent use;
(3) chitosan is joined in the remaining deionized water, stir, be heated to 80 ℃, after dissolving disperses, add B liquid, mix, get C liquid;
(4) A, C liquid are mixed, add nano silver colloidal sol liquid, regulating pH value with the pH value regulator is 6 ~ 7, adds foaming agent, and ultrasonic homogenizing 30 minutes makes homogeneous solution;
(5) with in the homogeneous solution fill pressure bottle, add propellant, be prepared into nanometer and scald burn, ulcer wound disinfection sterilization foam.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104148687A CN102872160A (en) | 2012-10-26 | 2012-10-26 | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104148687A CN102872160A (en) | 2012-10-26 | 2012-10-26 | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102872160A true CN102872160A (en) | 2013-01-16 |
Family
ID=47473830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104148687A Pending CN102872160A (en) | 2012-10-26 | 2012-10-26 | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102872160A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103622995A (en) * | 2013-11-05 | 2014-03-12 | 上海大学 | Externally-applied nano silver preparation and preparation method thereof |
| CN105596367A (en) * | 2015-12-31 | 2016-05-25 | 南方医科大学 | Nano-silver antibacterial gel with chitosan-poloxamer as gel matrix and preparation method and application of nano-silver antibacterial gel |
| CN106963808A (en) * | 2017-05-26 | 2017-07-21 | 威海美迪森医疗器械有限公司 | A kind of burn-scald medicine compositions and its preparation method and application |
| CN109453416A (en) * | 2018-12-29 | 2019-03-12 | 叶润芃 | Can quickly alleviating pain and mitigate scald depth plant society dressing |
| CN109568647A (en) * | 2017-09-28 | 2019-04-05 | 上海君联医疗设备有限公司 | Foam type chitosan liquid film and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525980A (en) * | 2001-04-23 | 2004-08-26 | ニュクリスト ファーマシューティカルズ コーポレーション | Use of metals for treatment of mucous membranes |
| CN1743003A (en) * | 2005-09-30 | 2006-03-08 | 周旭明 | Compound preparation for anti-pregnancy by kiilling sperm and sterilizing and preparing method |
| CN1943593A (en) * | 2006-11-03 | 2007-04-11 | 段炬红 | External use anti-bacteria foaming agent for gynecology |
| CN101278896A (en) * | 2008-05-23 | 2008-10-08 | 山东赛克赛斯药业科技有限公司 | Chitosan nano silver gel agent and uses thereof |
| CN101352454A (en) * | 2008-09-11 | 2009-01-28 | 崔彬 | External-use gel foamable composition for gynecology inflammation and obesity |
| CN102058886A (en) * | 2010-12-20 | 2011-05-18 | 云南白药集团无锡药业有限公司 | Medical powder inhalation and application thereof |
| KR20120035032A (en) * | 2010-10-04 | 2012-04-13 | 한국원자력연구원 | Hydrogels for wound dressing comprising nano-silver particle and preparation method thereof |
-
2012
- 2012-10-26 CN CN2012104148687A patent/CN102872160A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525980A (en) * | 2001-04-23 | 2004-08-26 | ニュクリスト ファーマシューティカルズ コーポレーション | Use of metals for treatment of mucous membranes |
| CN1743003A (en) * | 2005-09-30 | 2006-03-08 | 周旭明 | Compound preparation for anti-pregnancy by kiilling sperm and sterilizing and preparing method |
| CN1943593A (en) * | 2006-11-03 | 2007-04-11 | 段炬红 | External use anti-bacteria foaming agent for gynecology |
| CN101278896A (en) * | 2008-05-23 | 2008-10-08 | 山东赛克赛斯药业科技有限公司 | Chitosan nano silver gel agent and uses thereof |
| CN101352454A (en) * | 2008-09-11 | 2009-01-28 | 崔彬 | External-use gel foamable composition for gynecology inflammation and obesity |
| KR20120035032A (en) * | 2010-10-04 | 2012-04-13 | 한국원자력연구원 | Hydrogels for wound dressing comprising nano-silver particle and preparation method thereof |
| CN102058886A (en) * | 2010-12-20 | 2011-05-18 | 云南白药集团无锡药业有限公司 | Medical powder inhalation and application thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103622995A (en) * | 2013-11-05 | 2014-03-12 | 上海大学 | Externally-applied nano silver preparation and preparation method thereof |
| CN105596367A (en) * | 2015-12-31 | 2016-05-25 | 南方医科大学 | Nano-silver antibacterial gel with chitosan-poloxamer as gel matrix and preparation method and application of nano-silver antibacterial gel |
| CN105596367B (en) * | 2015-12-31 | 2018-11-27 | 南方医科大学 | Using chitosan-poloxamer as nano silver antimicrobial gel of gel-type vehicle and its preparation method and application |
| CN106963808A (en) * | 2017-05-26 | 2017-07-21 | 威海美迪森医疗器械有限公司 | A kind of burn-scald medicine compositions and its preparation method and application |
| CN109568647A (en) * | 2017-09-28 | 2019-04-05 | 上海君联医疗设备有限公司 | Foam type chitosan liquid film and preparation method thereof |
| CN109453416A (en) * | 2018-12-29 | 2019-03-12 | 叶润芃 | Can quickly alleviating pain and mitigate scald depth plant society dressing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101278896B (en) | Chitosan nano silver gel agent and uses thereof | |
| CN105056237B (en) | Physical method of combating microorganisms | |
| JP5615717B2 (en) | Chitosan gel for dermatological use, its production method and use | |
| CN105055642A (en) | Compound guanidine disinfectant and preparation method of compound guanidine disinfectant | |
| CN102091097B (en) | Washing-free puerpera perineum medical-care gel and preparation method thereof | |
| EP2937101A1 (en) | Semi-fluidic composition for lubricating, moisture retaining, disinfecting, sterilizing and method using the same | |
| CN105362212A (en) | Washing-free sterilizing gel and preparing method thereof | |
| CN102872160A (en) | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds | |
| CN108158995A (en) | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof | |
| CN102846655A (en) | Formulation and preparation method of antibacterial spray | |
| WO2011085484A1 (en) | Antimicrobial nitric oxide compositions | |
| CN106176688A (en) | A kind of wound repair liquid and preparation method thereof | |
| CN103356738A (en) | Skin disinfection gel and its application | |
| CN105640916A (en) | Povidone iodine effervescent tablets with anti-microbial, skin-care and anti-inflammation functions and production process of povidone iodine effervescent tablets | |
| CN105623868A (en) | Nano-silver washing solution and preparation method thereof | |
| CN105079858A (en) | Liquid dressing capable of sterilizing and repairing wounds and production method of liquid dressing | |
| CN107982277B (en) | Composite antibacterial aerosol and preparation method and application thereof | |
| CN102871864B (en) | Antimicrobial and dandruff-removing nano-silver hair foaming emulsion | |
| CN102251438B (en) | Antiseptic fragrant paper towel and manufacturing method thereof | |
| CN105497087A (en) | Slow release gel loaded with sanqi and nanometer zinc oxide, preparing method thereof and applications of the slow-release gel | |
| WO2008104076A1 (en) | Electrocolloidal silver and echinacea root antimicrobial formulation | |
| CN102697804B (en) | Solid molecular iodine disinfectant and preparation method thereof | |
| CN100396290C (en) | External use anti-bacteria foaming agent for gynecology | |
| CN101642467B (en) | Long-acting disinfection paste | |
| CN104586899A (en) | Aerosol for treating bedsore and preparation method of aerosol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130116 |