CN101352454A - External-use gel foamable composition for gynecology inflammation and obesity - Google Patents

External-use gel foamable composition for gynecology inflammation and obesity Download PDF

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Publication number
CN101352454A
CN101352454A CNA2008100131572A CN200810013157A CN101352454A CN 101352454 A CN101352454 A CN 101352454A CN A2008100131572 A CNA2008100131572 A CN A2008100131572A CN 200810013157 A CN200810013157 A CN 200810013157A CN 101352454 A CN101352454 A CN 101352454A
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external
foamable composition
use gel
sodium
foaming agent
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CNA2008100131572A
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崔彬
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Abstract

The invention discloses a gel foaming agent used for treating gynecological inflammation and adiposity through external application. The gel foaming agent is composed of nano silver, weight-reducing medicine, a foaming agent, a transdermal absorption agent and an excipient. The invention describes the characters of the medicine such as formulation composition, preparation technique and disposable packaging. The gel foaming agent for external application can be applied on the skin or mucous membranes and has significant curative effects for treating vaginitis, cervicitis, cervical erosion, mixed infection type gynecological inflammation and adiposity; furthermore, the gel foaming agent for external application has great significance for popularization in industrial production.

Description

A kind of external-use gel foamable composition that is used for gynecological inflammation and obesity
Technical field
The present invention relates to a kind of composition of medicine for the treatment of gynecological inflammation and obesity, specifically a kind of treat above-mentioned disease, be the external-use gel foamable composition that main component is made by nanometer silver and slimming medicine, and the industrialization production method and the application of this medicine.The technical field that belongs to medicine and preparation method thereof.
Background technology
Common gynecologic inflammation has: vaginitis, cervicitis, pelvic inflammatory disease, adnexitis etc.Normally because due to the infection of antibacterial or virus.Show that according to World Health Organization's latest survey report for the adult female, modal disease is not a flu, but reproductive tract infection; Modal malaise symptoms is not heating, headache etc., but the pruritus at secret place, abnormal flavour, pain etc.The probability that the adult female suffers from reproductive tract infection is 61%; The time that nearly 60% women took out 3-6 days every month is used for treating reproductive tract infection.Women crowd's health, work, life, happy family life in serious harm.At present, the medicine of treatment genital diseases is more on the market, and its main product is an antibiotic medicine.Life-time service is easy to generate Drug resistance and the home of destroying vagina.See from dosage form mostly to be oral medicine, suppository, washing liquid etc., so the general treatment effect is bad, treatment cycle is long, and the relapse rate height.
Obesity be meant the body fat overheap and (or) distribute unusually, the body constitution amount increases, and is a kind of multifactorial chronic metabolic disease.The improvement of material life condition and dietary structure unreasonable, obesity sickness rate are soaring year by year.Obesity not only influences figure and activity as a kind of whole body incretion metabolism disease, and closely related with hyperlipemia, atherosclerosis, hypertension, coronary heart disease, diabetes etc.Obesity has become a kind of global chronic disease of serious threat human health.The appetrol of Chu Shouing are of a great variety in the market, but the external use to lose weight medicine of percutaneous or mucosal drug delivery is not seen listing.
Positive effect of the present invention is, overcomes the deficiency of existing medicine, and a kind of external used medicine combination for the treatment of gynecological inflammation and obesity is provided.Women's daily pudendum health care and fat-reducing are combined; By vagina administration, reduce the untoward reaction and the toxic and side effects of medicine; Adopt the foam of dark foam manufacturing technology and non-returnable container preparation, be easy to the dispersion and the absorption of medicine, the convenient use; Gel of the present invention, be the macromolecular network system with semi-solid property, what it can the long period closely pastes with site of action, and better biocompatibility is arranged, and formed aquation gel layer after the gel imbibition has certain sustained release effect to medicine.Be applicable to the percutaneous or the mucosal drug delivery system of gynecological's antiinflammatory, fat-reducing.The preparation of above-mentioned innovative characteristics does not appear in the newspapers in patent retrieval.
Summary of the invention
One of purpose of the present invention provides the external used medicine combination of a kind of wide spectrum, efficient, safe treatment gynecological inflammation and obesity, especially has the gel foam agent medicine of slow-releasing.
Two of purpose of the present invention provides the industrialized producing technology of this gel foam agent medicine.
Further aim of the present invention provides the purposes of gel foam agent medicine.
Technical scheme of the present invention is achieved in that
A kind of external-use gel foamable composition for the treatment of gynecological inflammation and obesity, it is made up of nanometer silver antimicrobial colloid (or other antibacterial), slimming medicine, foaming agent, cutaneous permeable agent and excipient.
Described nanometer silver antimicrobial colloid is a particle diameter at 1-100nm, be uniformly distributed in and have antibacterial activity simple substance silver on the carrier material.About related contents such as the colloidal preparation of this nanometer silver antimicrobial, antibacterial mechanisms and characteristics, the patent that the inventor declared in 2007 " a kind of slowly-released type nanometer silver antibacterial gel and preparation method thereof and application ", application number: 200710011582.3 elaboration and claim are applicable to patent of the present invention;
Said other antibacterial comprise one or more in the elimination agent of beta-lactam antibiotic or fluorine-containing, chlorine, bromine, I;
Said slimming medicine, comprise chemosynthesis or natural drug in have one or more active component of antiobesity action, one or more combination in preferred Li Monaban (ACOMPLIA), sibutramine (sibtramine), orlistat (orlistat), eastern cloth Qu Ming, the Resina garciniae extract.
Said foaming agent is selected from the alkane derivative one or more combination, as sodium lauryl sulphate, sodium lauroyl sarcosine etc.
Said cutaneous permeable agent comprises that pharmaceutics allows the cutaneous permeable agent that uses.In preferred Herba Menthae, Borneolum Syntheticum, azone, the dimethyl sulfoxide one or more.
Said excipient is polyacrylic material or cellulosic material.Preferred carbomer, Polycarbophil, CBP and Polyethylene Glycol etc., or one or more combination wherein
Prescription of the present invention constitutes:
Nanometer silver 1-50 part, Li Monaban 0.1-50 part, sodium lauroyl sarcosine 10-200 part, sodium lauryl sulphate 10-100 part, coconut oil fatty acid monoethanolamide 10-150 part, tetrasodium ethylenediamine tetraacetate 1-10 part, sodium benzoate 1-5 part, sodium chloride 1-20 part, Borneolum Syntheticum 0.5-5g, Sodium Tvlose 1-15g, Borneolum Syntheticum 1-2 part, Mentholum 1-3 part, essence is an amount of, and pure water is an amount of.
The present invention preferably writes out a prescription to constitute:
Nanometer silver 1-20 part, Li Monaban 0.5-2 part, sodium lauroyl sarcosine 150-200 part, sodium lauryl sulphate 60-100 part, coconut oil fatty acid monoethanolamide 80-150 part, tetrasodium ethylenediamine tetraacetate 2-5 part, sodium benzoate 2-5 part, sodium chloride 5-10 part, Borneolum Syntheticum 0.5-2g, Sodium Tvlose 5-10g, Borneolum Syntheticum 1-2 part, Mentholum 1-3 part, essence is an amount of, and pure water is an amount of.
Technological process of the present invention: it is to adopt existing gel foam preparation technique to realize.It is an independent packaging unit that its inner packing adopts a drug dose.Concrete technology: with sodium lauroyl sarcosine, sodium lauryl sulphate, tetrasodium ethylenediamine tetraacetate, sodium benzoate add in the deionized water, high-speed stirred Hybrid Heating to 70 degree heating for dissolving; Coconut oil fatty acid monoethanolamide is added in the deionized water, and heating for dissolving expands; Borneolum Syntheticum is pulverized, used dissolve with ethanol respectively with Mentholum.Above-mentioned solution merges, and successively with nanometer silver, Li Monaban, sodium chloride join in the solution, fully stirs, and transfers PH6.0-7.0 with calcium hydroxide, packing, quality inspection, dispatches from the factory.
Intention novelty of the present invention constitutes simply, and cost is moderate, is applicable to the big popularization of producing of industry.Product of the present invention is mainly used in the women and treats all kinds of vaginitiss, cervicitis, cervical erosion, leucorrhea abnormal etc., improves the vagina self-cleaning function; And effectively regulate the metabolic balance of body, the bodily form of keeping fit is realized health slimming.
The specific embodiment
In conjunction with experimental data, be described in detail the specific embodiment of the present invention.Cited embodiment is in order to help those skilled in the art more fully to understand the present invention.But the right that does not limit the present invention in any way.
Embodiment one:
Prescription is formed:
16 parts of nanometer silvers, 1.6 parts of Li Monaban, 150 parts of sodium lauroyl sarcosines, 60 parts of sodium lauryl sulphates, 80 parts of coconut oil fatty acid monoethanolamides, 5 parts of tetrasodium ethylenediamine tetraacetates, 3 parts of sodium benzoate, 8 parts in sodium chloride, Sodium Tvlose 5-10g, Borneolum Syntheticum 2g,, Mentholum 1-3 part, essence is an amount of, and pure water is an amount of.Make 1000g.
Preparation technology:
1, with sodium lauroyl sarcosine, sodium lauryl sulphate, tetrasodium ethylenediamine tetraacetate, sodium benzoate add in the deionized water, and high-speed stirred Hybrid Heating to 70 degree heating for dissolving gets A solution.
2, coconut oil fatty acid monoethanolamide is added in the deionized water, heating for dissolving expands, and gets B solution
3, B solution is under agitation slowly added A solution, stir, get C solution.
4, Borneolum Syntheticum is pulverized, used dissolve with ethanol respectively, get D solution with Mentholum.
5, the C solution stirring is cooled to 30 degree, successively with nanometer silver, Li Monaban, sodium chloride, D solution join in the C solution, fully stir,
6, transfer PH6.0-7.0 with calcium hydroxide,
7, with the plastics injector fill of manufactured goods with the composite sanitary standard, every 3-4g.
Embodiment two:
Prescription is formed:
10 parts of nanometer silvers, 2 parts of sibutramine, 200 parts of sodium lauroyl sarcosines, 90 parts of sodium lauryl sulphates, 100 parts of coconut oil fatty acid monoethanolamides, 3 parts of tetrasodium ethylenediamine tetraacetates, 3 parts of sodium benzoate, 8 parts in sodium chloride, Acritamer 940 10g, Borneolum Syntheticum 2g, Mentholum 1-3 part, essence is an amount of, pure water is an amount of.
Preparation technology:
Preparation method is with embodiment one.
Effect example one: in-vitro antibacterial experimental result of the present invention
To escherichia coli bacteriostatic experiment result
Annotate: the equal asepsis growth of negative control group
To Candida albicans bacteriostatic experiment result
Figure A20081001315700082
Annotate: the equal asepsis growth of negative control group
Above experimental result is provided by Liaoning Province Center for Disease Control (CDC)
Effect example two:
External of the present invention is to colpitic therapeutic outcome
Figure A20081001315700092

Claims (10)

1, a kind of external-use gel foamable composition for the treatment of gynecological inflammation and obesity.It is characterized in that: described external-use gel foamable composition, it is made up of nanometer silver antimicrobial colloid (or other antibacterial), slimming medicine, foaming agent, cutaneous permeable agent and excipient.The external used medicine that is prepared from through specific process.
2, the described nanometer silver antimicrobial colloid of claim 1.It is characterized in that: described nanometer silver antimicrobial colloid be particle diameter at 1-100nm, be uniformly distributed on the carrier material, have antibacterial activity simple substance silver.
3, described other antibacterial of claim 1 is characterized in that: said other antibacterial comprise one or more in the elimination agent of beta-lactam antibiotic or fluorine-containing, chlorine, bromine, I.
4, the described slimming medicine of claim 1 is characterized in that: said slimming medicine, comprise chemosynthesis or natural drug in have one or more active component of antiobesity action.One or more combination in preferred Li Monaban (ACOMPLIA), sibutramine (sibtramine), orlistat (orlistat), eastern cloth Qu Ming, the Resina garciniae extract.
5, the described said foaming agent of claim 1, it is characterized in that: said foaming agent is the combination of one or more active component in the alkane derivative, as sodium lauryl sulphate, sodium lauroyl sarcosine etc.
6, the described said cutaneous permeable agent of claim 1 is characterized in that: said cutaneous permeable agent comprises that pharmaceutics allows the cutaneous permeable agent that uses.In preferred Herba Menthae, Borneolum Syntheticum, azone, the dimethyl sulfoxide one or more.
7, the described said excipient of claim 1 is characterized in that: said excipient is polyacrylic material or cellulosic material.Preferred carbomer, Polycarbophil, CBP and Polyethylene Glycol etc., or one or more combination wherein
8, the described said external-use gel foamable composition of claim 1, it is characterized in that: said external-use gel foamable composition prescription formation is: nanometer silver 1-20 part, Li Monaban 0.5-2 part, sodium lauroyl sarcosine 150-200 part, sodium lauryl sulphate 60-100 part, coconut oil fatty acid monoethanolamide 80-150 part, tetrasodium ethylenediamine tetraacetate 2-5 part, sodium benzoate 2-5 part, sodium chloride 5-10 part, Borneolum Syntheticum 0.5-2g, Sodium Tvlose 5-10g, Borneolum Syntheticum 1-2 part, Mentholum 1-3 part, essence is an amount of, and pure water is an amount of.
9, the specific process of the described external-use gel foamable composition of claim 1 is characterized in that: it is to adopt existing gel foam preparation technique to realize.It is an independent packaging unit that its inner packing adopts a drug dose.
10, the purposes of the described external-use gel foamable composition of claim 1.It is characterized in that: described external-use gel foamable composition is used for the treatment of all kinds of vaginitiss, cervicitis, cervical erosion, leucorrhea abnormal etc.; Effectively regulate the metabolic balance of body, the bodily form of keeping fit is realized health slimming.
CNA2008100131572A 2008-09-11 2008-09-11 External-use gel foamable composition for gynecology inflammation and obesity Pending CN101352454A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102872160A (en) * 2012-10-26 2013-01-16 广东同德药业有限公司 Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds
EP4101467A4 (en) * 2020-02-05 2024-03-06 NOF Corporation Agent for treating or preventing pancreatic fistula

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102872160A (en) * 2012-10-26 2013-01-16 广东同德药业有限公司 Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds
EP4101467A4 (en) * 2020-02-05 2024-03-06 NOF Corporation Agent for treating or preventing pancreatic fistula

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