CN102648922A - Gamuzhuer medicinal latex preparation and preparation method thereof - Google Patents
Gamuzhuer medicinal latex preparation and preparation method thereof Download PDFInfo
- Publication number
- CN102648922A CN102648922A CN2011100432764A CN201110043276A CN102648922A CN 102648922 A CN102648922 A CN 102648922A CN 2011100432764 A CN2011100432764 A CN 2011100432764A CN 201110043276 A CN201110043276 A CN 201110043276A CN 102648922 A CN102648922 A CN 102648922A
- Authority
- CN
- China
- Prior art keywords
- zhu
- loud
- pitched sound
- wood
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention provides a Gamuzhuer medicinal latex preparation and a preparation method thereof. The Gamuzhuer medicinal latex preparation comprises the following components by weight percentage: 10-40% of Gamuzhuer, 0.1-8% of bioadhesive agent, 0.1-5% of non-ionic emulsifier, 1-30% of glycerol, 0-30% of grease and the balance of water. The bioadhesive material is bond with the Gamuzhuer, so that medicines are dispersed and adhered to a focus part so as to achieve a therapeutic aim; the Gamuzhuer latex preparation has a higher content, is more convenient to administer and is not added with any irritant solvent; the acting time is prolonged; during preparation, a proper amount of emulsifier is added, so that dissolution of musk and borneol can be promoted; compared with the conventional powdery preparation, the latex preparation takes effect more quickly; a proper amount of grease and a proper amount of emulsifier are added to achieve a good lubricating effect; the grain diameter of the medicinal powder is optimized, so that 99 percent of the powder is smaller than 100 um and thus the stability of the medicinal powder is improved; and the medicines have antibacterial and antiseptic functions, so that a preservative is not required.
Description
Technical field
The present invention relates to a kind of loud, high-pitched sound wood Zhu Er emulsion agent and preparation method thereof.
Background technology
Traditional Mongolia patent drug loud, high-pitched sound wood Zhu Er belongs to Mongolian medicine's classic prescriptions, and each clinical line is used for many years in the Inner Mongol.Loud, high-pitched sound wood Zhu Er is made up of Borneolum Syntheticum, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, Mirabilitum crystallina, Moschus 7 flavor medicines, has functions such as granulation promoting, convergence, is used for aphtha of the mouth and tongue, ulcer, pharyngitis, skin ulceration, trauma infection contamination, diseases such as cervical erosion.Loud, high-pitched sound wood Zhu Er is a compound preparation, wherein has 5 compositions to record into one one of 2005 editions Chinese Pharmacopoeia, is respectively Realgar, Cinnabaris, Concha Haliotidis, Borneolum Syntheticum and Moschus, is reducing swelling and alleviating pain, the dysmenorrhea of invigorating blood circulation, the refreshment of having one's ideas straightened out, detoxifcation parasite killing mostly.Vermilion is recited as in Compendium of Material Medica and cures mainly that stupid painful abdominal mass does not close up, the wet bleb of yellow fluid, flame erysipelas etc.; The medicinal herbs most in use selected works record into Mirabilitum crystallina be resolving heat and reducing pathogenic fire, the repellent of having one's ideas straightened out.Above-mentioned seven flavor medicine form conventional dosage forms---external-use ulcer powder is the externally applied anti-inflammation good recipe, xeothermic with clear Ba Da in the side, the medicine Mirabilitum crystallina of curing the wound is main, is equipped with heat-clearing and toxic substances removing, reducing swelling and alleviating pain medicine Borneolum Syntheticum is auxilliary; Realgar is held back skin ulcer to end corruption, kills sticking detumescence, and Vermilion, Cinnabaris are cured the wound with heat clearing away, and Concha Haliotidis is cured the wound with dry yellow fluid, and Moschus is sticking to kill, pain relieving; Make for assistant altogether.Each medicine share, and has possessed granulation promoting and has cured the wound, and kills sticking anti-inflammatory effect, therefore so to various ulcer, inflammation all has specially good effect.
Mongolian medicine loud, high-pitched sound wood Zhu Er merges the evident in efficacy of skin infection or trauma in treatment, to mucocutaneous ulcer, have and ooze out and rotten to the corn skin eczema and the total effective rate of viral dermatosis can reach more than 95%.In ulcerative colitis, also there is report to adopt loud, high-pitched sound wood Zhu Er treatment, total effective rate is 90.5%.Cervical erosion is commonly encountered diseases, the frequently-occurring disease of gynecological, belongs to the traditional Chinese medical science " leukorrheal diseases " category, and sickness rate accounts for about 60% of gynecological's outpatient service, with the substantial connection that has of cervical cancer.Loud, high-pitched sound wood Zhu Er treats the evident in efficacy of cervical erosion, more and more comes into one's own.(Chinese national folk medical magazine,, 4 volume supplementary issues: 17) select 25～50 years old in 1998 such as Bao Guilan; Non-pregnancy, and do not accept other method therapist in 3 months, with loud, high-pitched sound wood Zhu Er treatment cervical erosion 40 examples; The next day, add medicine to, and 7～10 days is 1 course of treatment, and cure rate is 97.5%.He Xiaohong etc. (western medical science, 2006,18 (3): 186～187) choose be diagnosed as in the cervix uteri, patient's 100 examples that micro-wave therapeutic is carried out in the severe erosion, be divided into two groups at random, seminar gives microwave and adds loud, high-pitched sound wood Zhu Er treatment, matched group only gives micro-wave therapeutic.The result shows: seminar's 50 examples, cure 46 examples, and cure rate is 92%; Matched group 50 examples are cured 33 examples, and cure rate is 70%, two group and compares that difference has statistical significance.The cure rate of microwave combined loud, high-pitched sound wood Zhu Er treatment cervical erosion is high, and complication is few, and the meaning of popularization is arranged.
Loud, high-pitched sound wood Zhu Er is used for granulation promoting, convergence, cures mainly ulcer, pharyngitis, skin ulceration, trauma infection contamination, cervical erosion etc., and is evident in efficacy.But loud, high-pitched sound wood Zhu Er is in treatment, and its a plurality of components are mineral powders, sprays with powder during administration or is applied in the affected part, not only use inconvenience, and dosage is difficult to guarantee.Bibliographical information exterior-applied gel and the research of liniment of loud, high-pitched sound wood Zhu Er; Content of dispersion is about 8%, but in the preparation process, all adopts the dissolve with ethanol Borneolum Syntheticum, the amount of ethanol that has even reach 20%; The pain that can cause wound or ulcer more is not suitable for vagina administration.(Jia Haibo, the preparation and the stability study of loud, high-pitched sound wood Zhu Er gel, Chinese national medicine magazine, 2003,9 (2): 41; Like the people, Jia Haibo, Jia Haiying, the zest of loud, high-pitched sound wood Zhu Er liniment is investigated Chinese national medicine magazine, 1999,5 (2): 41; Like the people, Jia Haibo, Jia Haiying, the preparation and the quality control of loud, high-pitched sound wood Zhu Er liniment, Chinese national medicine magazine, 1999,5 (4): 41)
Also have research to be made into suppository and use, but owing to contain mineral and large usage quantity in the compound recipe, the molding difficulty of its suppository is big, is difficult to preparation to make things convenient for its gynecological.Chinese patent 200610112027.5 relates to a kind of mongolian medicine of treating gynecological inflammation, adopts pharmaceutically active ingredient in the alcohol extraction in the preparation process, and remaining ethanol also has bigger zest; And used sodium lauryl sulphate to be emulsifying agent during preparation, the anion emulsifier zest is also bigger.
With reference to former application method and good curative effect thereof, Borneolum Syntheticum need not be dissolved in the ethanol equal solvent, but also onset of loud, high-pitched sound wood Zhu Er.Therefore, avoid the use of adjuvant and prepare novel loud, high-pitched sound wood Zhu Er, can be used for dermatosis outward, also can pour into special doser vagina administration with potential stimulus property.In addition, the composition of loud, high-pitched sound wood Zhu Er contains several mineral materials, and its density is bigger, and in common Emulsion or gel, oarse-grained powder causes medicine inhomogeneous sedimentation gradually, therefore, the particle diameter of drug powder is controlled, with being beneficial to the stable of medicine.
Summary of the invention
First purpose of the present invention provides a kind of loud, high-pitched sound wood Zhu Er emulsion agent, to satisfy the needs of clinical practice.
Second purpose of the present invention is to provide the method for preparing of said loud, high-pitched sound wood Zhu Er emulsion agent.
Said loud, high-pitched sound wood Zhu Er emulsion agent comprises following components in weight percentage:
Said loud, high-pitched sound wood Zhu Er is made up of Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, Borneolum Syntheticum and Moschus 7 flavor medicines, and the parts by weight of each component are:
35 parts of Mirabilitum crystallinas, 10 parts of Realgars, 5 parts in Cinnabaris, 5 parts of Vermilion, 5 parts of Concha Haliotidis, 25 parts of Borneolum Syntheticums, 0.5 part in Moschus;
Take by weighing each component, porphyrize, comminution by gas stream behind the 80 order primary dcreening operations, the particle diameter of 99% powder are less than the powder of 150 μ m, and the particle diameter of preferred 99% powder is less than 100 μ m;
Said bioadhesive polymer be for absorbing water and form the macromolecular material of gel, selects a kind of in the macromolecular material of gelatin substance, synthetic of natural extract or several for use;
The gelatin substance of said natural extract is selected from alginate, arabic gum, Lac, chitosan, tragakanta, pectin or agar etc.;
The macromolecular material of said synthetic is selected from carboxymethyl starch sodium, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate or Polyethylene Glycol etc.;
Said oils and fats is selected from synthetic ester oil such as decanoyl/octanoyl glycerides, vaseline, liquid paraffin, lanoline, dimethicone, hexadecanol, octadecanol, tristerin etc.; Or natural plant grease such as Oleum Glycines, Oleum Cocois, Oleum Camelliae or Semen arachidis hypogaeae wet goods, or animal oil such as fish oil etc. a kind of or several;
Said nonionic emulsifier is selected from a kind of in tween, span, poloxamer, polyoxyethylene aliphatic alcohol ether, the polyoxyethylene fatty acid ester or several;
Preferably, said loud, high-pitched sound wood Zhu Er emulsion agent comprises following components in weight percentage:
Method for preparing of the present invention comprises the following step:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers consumption;
(2) with the bioadhesive polymer of recipe quantity with suitable quantity of water dissolving or swelling after, mix with the medicine of step (1), the consumption of water is 30～80% of a total water amount;
(3) with the oils and fats and the surplus emulsifier of recipe quantity, can be heated to 50～60 ℃ if needed and melt, add the water of prescription surplus, mix, stir, put the cold Emulsion that gets;
(4) Emulsion of step (3) is joined the product of step (2), mixing promptly gets loud, high-pitched sound wood Zhu Er emulsion agent.
Or following steps:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers gross weight consumption;
(2) behind the water dissolution or swelling of bioadhesive polymer with recipe quantity, add the emulsifying agent of surplus, mix with the medicine of step (1) with recipe quantity;
(3) mixture of step (1) is joined the product of step (2), mixing promptly gets.
Loud, high-pitched sound wood Zhu Er emulsion agent of the present invention; Can be used for treating common gynecological diseases such as cervical erosion; Method for using is following: the vagina that loud, high-pitched sound of the present invention wood Zhu Er emulsion agent is sent into the patient who needs treatment through administrator gets final product, and dosage specifically can be according to patient's age etc., is determined by the doctor; Also can be used for skin diseases, loud, high-pitched sound wood Zhu Er emulsion agent of the present invention directly is applied in the affected part gets final product.
The present invention combines bioadhesive material with loud, high-pitched sound wood Zhu Er, make the medicine dispersion and adhere to lesions position, reaches therapeutic purposes.And need further be pointed out that, be not that all bioadhesive polymers all are applicable to the present invention, polyacrylate such as carbomer, although its good adhesion is widely used, after loud, high-pitched sound wood Zhu Er contacted, carbomer lost viscosity.In the preparation, earlier with medicated powder and glycerol, emulsifier, not only play good peptizaiton, emulsifying agent also can promote the dissolving of Borneolum Syntheticum and Moschus, the quickening onset.
Compared with prior art, loud, high-pitched sound wood Zhu Er emulsion agent content of dispersion of the present invention is higher, and administration is more convenient, and does not add any zest solvent, prolongs action time; Avoided heating during preparation, avoided Borneolum Syntheticum in the preparation process, to volatilize, guaranteed medicament contg owing to being heated to medicated powder; And in preparation, add an amount of emulsifying agent, can promote the dissolving of Moschus and Borneolum Syntheticum, compare traditional powder type, can accelerate onset time; And add an amount of oils and fats and emulsifying agent, can play good lubrication; Particle diameter to drug powder is optimized, and makes 99% powder less than 100 μ m, improves stability; Medicine itself has antibiotic anti-corrosion function, need not add antiseptic.
The specific embodiment
Embodiment 1
According to the mongolian medicine pharmacopeia, take by weighing Mirabilitum crystallina, Realgar, Concha Haliotidis, Cinnabaris, Vermilion, Moschus, Borneolum Syntheticum in proportion, porphyrize is crossed 80 order primary dcreening operations, and comminution by gas stream obtains required micronization principal agent.
Said loud, high-pitched sound wood Zhu Er is made up of Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, Borneolum Syntheticum and Moschus 7 flavor medicines, and the parts by weight of each component are:
35 parts of Mirabilitum crystallinas, 10 parts of Realgars, 5 parts in Cinnabaris, 5 parts of Vermilion, 5 parts of Concha Haliotidis, 25 parts of Borneolum Syntheticums, 0.5 part in Moschus;
Adopt laser diffractometry to measure powder diameter, concrete particle size distribution sees the following form.
| Sample | X 10(μm) | X 50(μm) | X 99(μm) |
| Sample 1 | 1.44 | 8.34 | 99.67 |
| Sample 2 | 1.10 | 3.95 | 59.52 |
| Sample 3 | 1.78 | 13.51 | 146.81 |
Embodiment 2
(1) takes by weighing loud, high-pitched sound wood Zhu Er 97.5g and 150g glycerol, the 10g Tween 80 mix homogeneously of embodiment 1;
(2) get bioadhesive polymer sodium alginate 2.5g water 64g swelling, add step (1) loud, high-pitched sound wood Zhu Er, mixing;
(3) get octadecanol 30g, white vaseline 20g, glyceryl monostearate 20g, liquid paraffin 30g, lanoline 20g, dimethicone 30g, be mixed and heated to 60 ℃; Add 5g sorbester p17,5g Tween 80 and 16g water, stir, put the cold Emulsion that gets;
(4) with the mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, and packing promptly gets.
Embodiment 3
(1) takes by weighing loud, high-pitched sound wood Zhu Er 200g and 100g glycerol, the 10g Tween 80 mix homogeneously of embodiment 1;
(2) get bioadhesive polymer sodium carboxymethyl cellulose 0.25g water 25g swelling, add step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) get white vaseline 30g, glyceryl monostearate 20g, liquid paraffin 30g, dimethicone 20g, be mixed and heated to 50 ℃; Add 4.75g Tween 80 and 60g water, stir, put the cold Emulsion that gets;
(4) with the mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, and packing promptly gets.
Embodiment 4
(1) takes by weighing loud, high-pitched sound wood Zhu Er 50g and 125g glycerol, the 8g polyoxyethylene castor oil mix homogeneously of embodiment 1;
(2) get bioadhesive polymer hydroxypropyl methylcellulose 15g water 150g swelling, add step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) get white vaseline 10g, glyceryl monostearate 15g, liquid paraffin 10g, lanoline 15g, be mixed and heated to 50 ℃; Add 7g polyoxyethylene castor oil and 95g water, stir, put the cold Emulsion that gets;
(4) with the mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, and packing promptly gets.
Embodiment 5
(1) takes by weighing loud, high-pitched sound wood Zhu Er 100g and 25g glycerol, the 4g polyoxyethylene castor oil mix homogeneously of embodiment 1;
(2) get bioadhesive polymer methylcellulose 40g water 250g swelling, add step (1) loud, high-pitched sound wood Zhu Er, mixing;
(3) get soybean oil 5g, add 1g polyoxyethylene castor oil and 75g water, stir, put the cold Emulsion that gets;
(4) with the mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, and packing promptly gets.
Embodiment 6
(1) takes by weighing loud, high-pitched sound wood Zhu Er 150g and 70g glycerol, the 0.5g poloxamer mix homogeneously of embodiment 1;
(2) get bioadhesive polymer chitosan 30g water 249.5g swelling, add step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) with the mixture and step (2) the mixture mix homogeneously of step (1), gross weight is 500g, and packing promptly gets.
Embodiment 7
(1) takes by weighing loud, high-pitched sound wood Zhu Er 115g and 5g glycerol, the 15g polyoxyethylene castor oil mix homogeneously of embodiment 1;
(2) get bioadhesive polymer hydroxypropyl methylcellulose 5g water 150g swelling, add step (1) loud, high-pitched sound wood Zhu Er, mixing;
(3) get white vaseline 50g, glyceryl monostearate 15g, liquid paraffin 60g and be mixed and heated to 50 ℃; Add 10g polyoxyethylene castor oil and 75g water, stir, put the cold Emulsion that gets;
(4) with the mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, and packing promptly gets.
Embodiment 8
(1) takes by weighing loud, high-pitched sound wood Zhu Er 125g and 130g glycerol, the 2.5g Tween 80 mix homogeneously of embodiment 1;
(2) get bioadhesive polymer polyvinylpyrrolidone 20g water 220g swelling, add 2.5g Tween 80 and step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) with the mixture and step (2) the mixture mix homogeneously of step (1), gross weight is 500g, and packing promptly gets.
Embodiment 9
For estimating the adhesiveness of loud, high-pitched sound wood Zhu Er emulsion agent, adopt agar culture medium simulation physiology mucosa to investigate.Take by weighing agar 0.75g, add 50ml water and stir, be heated to boiling after, be inverted dry culture dish, treat that its cooling promptly gets.Press embodiment 2,3,4,6 prescription preparation loud, high-pitched sound wood Zhu Er emulsion agents; And configuration and embodiment 2 prescriptions are identical but do not contain the preparation of bioadhesive polymer; Be applied on the agar culture medium, agar culture medium vertically is hung on the disintegration tester hook, places the pH6.8 phosphate buffer in the disintegrate cup; Liquid level was not advisable to have the culture medium peak, and the disintegrate temperature is 37 ℃.Start disintegration tester, the time that the record medicine all drops, the result sees the following form, the adding significant prolongation of bioadhesive polymer medicine adhere to the time.
Embodiment 10
48 of SD rats, the male and female dual-purpose, body weight 200 ± 20g is divided into 4 groups at random.Shaves hair in center, the back of every rat before the experiment, loses hair or feathers with depilatory cream shaving the territory, hair-fields, second day in no hair-fields the fresh bacterium liquid of the golden yellow Fructus Vitis viniferae ball of subcutaneous injection 0.2ml (about 500,000,000 antibacterials/ml)/, losing hair or feathers sordid animal need not.Inject and to see after three days that dense lump appears in subcutaneous rat.Each organizes the listed medicine of rat according to the form below and agent is applied in around the lump, every day secondary, totally 10 days.(maximum gauge, cm), and whether record festers to measure the lump size after 10 days.The result sees the following form.
| Group | Lump size (cm) | Percentage rate does not fester | Begin the detumescence time |
| Matched group | 1.365±0.3 | 33.8％ | - |
| The Mupirocin Ointment group | 0.935±0.188 | 70.0％ | 5 |
| Embodiment 2 | 0.905±0.284 | 75.0％ | 3 |
| Embodiment 6 | 0.925±0.212 | 70.6％ | 3 |
| Loud, high-pitched sound wood Zhu Er powder | 1.012±0.314 | 60.2％ | 5 |
Embodiment 11
Press embodiment 3 configuration samples, in addition, the processing of medicine heating disinfection after 30 minutes, is carried out bacteriostatic test with 3 kinds of standard bacterium, adopt the double dilution method of agar, quantitatively inoculate every some inoculation 10 with multiple spot inoculation appearance
5CFU cultivated 22 hours at 37 ℃, observed and the record result.Result of the test is minimum inhibitory concentration (MIC) with the least concentration of medicine bacteria growing inhibiting, and the result sees the following form, and sample has good bacteriostatic activity, and the MIC of heat treated sample obviously increases, and has destroyed the composition in the prescription, makes antibacterial activity reduce.
Antibacterial activity in vitro is MIC (mg/ml) relatively
| Strain name | The heat treated sample | Untreated samples |
| Golden yellow staphylococcus | 12.5 | 2 |
| Escherichia coli | 3.2 | 2 |
| Bacillus pyocyaneus | 200 | 4 |
Embodiment 12
Loud, high-pitched sound wood Zhu Er emulsion agent is carried out physical stability investigate, blank according to embodiment 2 configurations, and to use 99% particle diameter respectively be the loud, high-pitched sound wood Zhu Er powder preparation sample of 59.52,99.67,146.81 and 186.81 μ m; Get an amount of loud, high-pitched sound wood Zhu Er emulsion agent in the centrifuge tube of 1.5ml, with 3000r/m centrifugal 10 minutes, observe in the centrifuge tube particles settling or layering whether occur, the result sees the following form.
| X 99(μm) | Blank | 59.52 | 99.67 | 146.81 | 186.81 |
| Layering | Do not have | Do not have | Do not have | Do not have | Do not have |
| Particles settling | Do not have | Do not have | Do not have | Seldom | More |
Embodiment 13
Loud, high-pitched sound wood Zhu Er emulsion agent is carried out content of bornyl alcohol to be investigated; Prepare each 3 parts in sample respectively according to embodiment 4,8; Prescription with identical embodiment 4 disposes 3 parts in sample (being labeled as 4 ') by conventional method of preparing emulsion in addition, uses ethyl acetate extraction respectively, the gas chromatography determination content of bornyl alcohol.Chromatographic condition: with Polyethylene Glycol (PEG)-20M is immobile phase, and coating concentration is 10%; Column temperature: 135 ℃; Fid detector; Carrier gas is a nitrogen.As interior mark, ethyl acetate is a solvent, carries out determination of recovery rates with internal standard method with methyl salicylate, and the result sees the following form.
| Group | Borneolum Syntheticum response rate % |
| Embodiment 4 | 99.32±0.88 |
| Embodiment 6 | 99.75±0.48 |
| 4’ | 90.27±0.81 |
Claims (8)
1. loud, high-pitched sound wood Zhu Er medicine emulsion agent is characterized in that, comprises following components in weight percentage:
2. loud, high-pitched sound wood Zhu Er medicine emulsion agent according to claim 1 is characterized in that, said loud, high-pitched sound wood Zhu Er emulsion agent comprises following components in weight percentage:
3. loud, high-pitched sound wood Zhu Er medicine emulsion agent according to claim 1 and 2 is characterized in that said bioadhesive polymer is for absorbing water and form the macromolecular material of gel.
4. loud, high-pitched sound according to claim 1 and 2 wood Zhu Er medicine emulsion agent is characterized in that, said bioadhesive polymer is selected a kind of in the macromolecular material of gelatin substance, synthetic of natural extract or several for use;
The gelatin substance of said natural extract is selected from alginate, arabic gum, Lac, chitosan, tragakanta, pectin or agar;
The macromolecular material of said synthetic is selected from carboxymethyl starch sodium, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate or Polyethylene Glycol.
5. loud, high-pitched sound according to claim 1 and 2 wood Zhu Er medicine emulsion agent is characterized in that, said oils and fats is selected from a kind of in synthetic ester oil, natural plant grease or the animal oil or several.
6. loud, high-pitched sound wood Zhu Er medicine emulsion agent according to claim 5; It is characterized in that; Said oils and fats is selected from decanoyl/octanoyl glycerides, vaseline, liquid paraffin, lanoline, dimethicone, hexadecanol, octadecanol or tristerin; Natural plant grease is selected from Oleum Glycines, Oleum Cocois, Oleum Camelliae or Oleum Arachidis hypogaeae semen, and animal oil is a fish oil.
7. loud, high-pitched sound according to claim 1 wood Zhu Er medicine emulsion agent is characterized in that, said nonionic emulsifier is selected from a kind of in tween, span, poloxamer, polyoxyethylene aliphatic alcohol ether, the polyoxyethylene fatty acid ester or several.
8. according to the method for preparing of each described loud, high-pitched sound wood Zhu Er medicine emulsion agent of claim 1～7, it is characterized in that, comprise the following step:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers consumption;
(2) with the bioadhesive polymer of recipe quantity with suitable quantity of water dissolving or swelling after, mix with the medicine of step (1), the consumption of water is 30～80% of a total water amount;
(3) with the oils and fats and the surplus emulsifier of recipe quantity, can be heated to 50～60 ℃ if needed and melt, add the water of prescription surplus, mix, stir, put the cold Emulsion that gets;
(4) Emulsion of step (3) is joined the product of step (2), mixing promptly gets loud, high-pitched sound wood Zhu Er emulsion agent.
Or following steps:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers gross weight consumption;
(2) behind the water dissolution or swelling of bioadhesive polymer with recipe quantity, add the emulsifying agent of surplus, mix with the medicine of step (1) with recipe quantity;
(3) mixture of step (1) is joined the product of step (2), mixing promptly gets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100432764A CN102648922B (en) | 2011-02-23 | 2011-02-23 | Gamuzhuer medicinal latex preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100432764A CN102648922B (en) | 2011-02-23 | 2011-02-23 | Gamuzhuer medicinal latex preparation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102648922A true CN102648922A (en) | 2012-08-29 |
| CN102648922B CN102648922B (en) | 2013-09-25 |
Family
ID=46691153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100432764A Expired - Fee Related CN102648922B (en) | 2011-02-23 | 2011-02-23 | Gamuzhuer medicinal latex preparation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102648922B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983775A (en) * | 2016-01-19 | 2017-07-28 | 毕力格 | It is a kind of to treat anaesthetic spray of wound and preparation method thereof |
| CN109223829A (en) * | 2018-11-02 | 2019-01-18 | 海文峰 | It is a kind of for treating the drug of common body surface wound |
| CN113397084A (en) * | 2021-04-07 | 2021-09-17 | 江苏师范大学 | Novel natural preservative based on perillaldehyde and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911246A (en) * | 2006-08-29 | 2007-02-14 | 董根柱 | Mongolian medicine for treating gynecologic inflammation, and its prepn. method |
-
2011
- 2011-02-23 CN CN2011100432764A patent/CN102648922B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911246A (en) * | 2006-08-29 | 2007-02-14 | 董根柱 | Mongolian medicine for treating gynecologic inflammation, and its prepn. method |
Non-Patent Citations (3)
| Title |
|---|
| 巴雅尔等: "嘎木朱尔栓治疗慢性宫颈糜烂120例疗效观察", 《中国民族医药杂志》 * |
| 贾海波等: "嘎木朱尔凝胶剂的制备及稳定性研究", 《中国民族医药杂志》 * |
| 贾海鹰等: "不同基质制备嘎木朱尔涂膜剂的比较研究", 《内蒙古医学院学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983775A (en) * | 2016-01-19 | 2017-07-28 | 毕力格 | It is a kind of to treat anaesthetic spray of wound and preparation method thereof |
| CN106983775B (en) * | 2016-01-19 | 2020-05-15 | 毕力格 | Mongolian medicine spray for treating trauma and preparation method thereof |
| CN109223829A (en) * | 2018-11-02 | 2019-01-18 | 海文峰 | It is a kind of for treating the drug of common body surface wound |
| CN113397084A (en) * | 2021-04-07 | 2021-09-17 | 江苏师范大学 | Novel natural preservative based on perillaldehyde and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102648922B (en) | 2013-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5694665B2 (en) | Topical preparation and its usage | |
| WO2017101790A1 (en) | Pharmaceutical composition for treating cutaneous pruritus and use thereof | |
| CN105582383A (en) | Composition containing alkannin and lemon grass essential oil | |
| WO2022178983A1 (en) | External preparation of natural drug, preparation method, and application thereof | |
| CN102648922B (en) | Gamuzhuer medicinal latex preparation and preparation method thereof | |
| CN101342174B (en) | Phthiobuzonum/diclothane compound topical formulation | |
| CN104288222B (en) | A kind of Nano medication for treating cow endometritis and preparation method thereof | |
| CN102670690A (en) | Anti-psoriasis purely natural medicinal cream and preparation method thereof | |
| CN102397444A (en) | Nano-grade gynaecological lotion and preparation method thereof | |
| CN104338147A (en) | Ointment combination matrix for sustained-release drug delivery | |
| CN107184807A (en) | A kind of anti-acne detumescence facemask powder | |
| CN101152546B (en) | Externally used preparations with functions of anti-inflammation, relieving itching and sterilization disinfection, and method for preparing the same | |
| CN106822321B (en) | Application of Curcuma water of traumatology in preparing medicine for treating keratosis pilaris | |
| CN101982198B (en) | Perfusion medicinal oil for treating hysteritis of cow and preparation method thereof | |
| CN101332286B (en) | Traditional Chinese medicine composition for treating skin disease and preparation method thereof | |
| US20200315986A1 (en) | Cannabinoid and menthol gel compositions, patches and methods | |
| WO2021177940A1 (en) | Cannabinoid and menthol gel compositions, patches and methods | |
| CN112999294A (en) | Soft gel and preparation method and application thereof | |
| CN101757119B (en) | Medicine composition for treating vaginitis as well as gel and preparation method thereof | |
| CN112007075A (en) | Compound peppermint oil nanoemulsion composition and preparation method thereof | |
| CN104546885A (en) | Medicine composition for treating skin diseases as well as preparation method and application thereof | |
| CN113116916B (en) | A pharmaceutical composition for treating gynecological diseases, and its preparation method | |
| CN107050393A (en) | Numbness of relaxing dispersing paste and preparation method and application | |
| CN101991788A (en) | Preparation with effects of clearing heat and detoxicating, and diminishing swelling and relieving pain and preparation method thereof | |
| CN101468055A (en) | Gel patch for preventing and treating cerebral thrombosis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130925 Termination date: 20180223 |