CN107050393A - Numbness of relaxing dispersing paste and preparation method and application - Google Patents
Numbness of relaxing dispersing paste and preparation method and application Download PDFInfo
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- CN107050393A CN107050393A CN201710353742.6A CN201710353742A CN107050393A CN 107050393 A CN107050393 A CN 107050393A CN 201710353742 A CN201710353742 A CN 201710353742A CN 107050393 A CN107050393 A CN 107050393A
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- 231100000862 numbness Toxicity 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000002040 relaxant effect Effects 0.000 title description 4
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 49
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 49
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 49
- 241000269420 Bufonidae Species 0.000 claims abstract description 49
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 49
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 49
- 229940116229 borneol Drugs 0.000 claims abstract description 49
- 229930008380 camphor Natural products 0.000 claims abstract description 49
- 229960000846 camphor Drugs 0.000 claims abstract description 49
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 49
- 239000002435 venom Substances 0.000 claims abstract description 49
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- 239000002994 raw material Substances 0.000 claims abstract description 44
- 239000003292 glue Substances 0.000 claims abstract description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 30
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000706 filtrate Substances 0.000 claims abstract description 22
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- 238000001816 cooling Methods 0.000 claims description 10
- 208000004396 mastitis Diseases 0.000 claims description 7
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
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- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 description 1
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
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- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 229940083546 estradiol 0.5 mg Drugs 0.000 description 1
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- 206010016629 fibroma Diseases 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
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Classifications
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Developmental Biology & Embryology (AREA)
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- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of easypro numbness dispersing paste and preparation method and application, including following raw material components：Radix semiaquilegiae, ground bettle, camphor, selfheal, the dried venom of toads, dragon's blood, kelp, borneol, semen momordicae, the seed of garden balsam, curcuma zedoary, pangolin, marine alga and Malaysia glue.Preparation method：Raw material components in addition to dragon's blood, the dried venom of toads, camphor and borneol are well mixed, are soaked in ethanol water, filters and collects filtrate；Malaysia glue is heated to being completely melt, is well mixed afterwards with filtrate obtained above；Heating removes ethanol, when temperature is reduced to 20 DEG C, adds dragon's blood and the dried venom of toads and stirs；Camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.The easypro numbness dispersing paste that the present invention is provided is prepared from from the plant containing active skull cap components, prescription matches science, without any artificial synthesis group point, safe without toxic side effect, with instant effect, easy to operate, Small side effects, production cost is low and has the advantages such as very big application prospect.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of easypro numbness dispersing paste and preparation method and application.
Background technology
It is well known that female breast is the annex of reproductive system, it is one of vitals.Vigorous and graceful breast is contemporary women
Glamour and elegance, and some women because the flat small, mastoptosis of breast without elasticity worried, particularly also various mammary gland diseases
Disease, such as：The proliferation of mammary gland, mammary gland fibroma, mastitis, breast caking etc. caused by tuberculosis of breast.Especially in recent years, with existing
For the quickening of rhythm of life, women work, the influence of life stress have such disease and increase trend, brought greatly to patient
Pain, has a strong impact on the quality of life and health of people, especially nursing period women, influences big because having taboo and side effect more
Husband's medication.Moreover, in urban woman, mammary gland disease becomes No.1 formidable enemy.Such disease as treated not in time and malpractice,
May occur lesion, mutation causes life danger at any time.According to statistics, 70%~90% women has proliferation of mammary gland problem, hair
Sick rate is at a relatively high.
For above-mentioned female breast disease, definite effective medicine there is no both at home and abroad at present.It is external female using being directed to always
Hormone increases from the treatment method for suppressing estrogen drugs, and medicine used has TAM, thyroid hormones preparation, bromine
Hidden booth, danazol, enzyme, vitamins, low dose of idodine and gonadotherapy etc..This disease is treated using these methods, only
Bitterly, the block that disappears is made good use of, but because its side effect is big, especially sex hormone, between the hormone that human body may be further disturbed after
Balance, and increase the possibility of canceration；Therefore it is as far as possible few with or without only in serious symptom, just consideration is applied.To severe hyperplasia
There is canceration tendency person, then take operative treatment, but Postoperative recurrent rate is higher.It is domestic clinically main in for the sick treatment
Based on medicine, including JIAWEI XIAOYAOWAN, Xiaoyao San, xiaojin pill, Ru Pi Ling", newborn block disappear.All Chinese medicines are all analgesics, alleviate disease
The phenomenon that lump recurs with symptom after shape, and drug withdrawal.In addition, the physical method length such as hot compress exist slowly effect, less effective and often
Often the shortcomings of recurrence.
Based on this, a kind of instant effect of production, easy to operate, Small side effects newtype drugs are needed badly, effectively to cure or alleviate
The common gynecological diseases such as mastitis, the proliferation of mammary gland or caking.
The content of the invention
For defect of the prior art, the present invention is intended to provide a kind of easypro numbness dispersing paste and preparation method and application.
The easypro numbness dispersing paste that the present invention is provided is prepared from from the plant containing active skull cap components, prescription proportioning science, without
Any artificial synthesis group point, safe without toxic side effect, with instant effect, easy to operate, Small side effects, production cost is low and has very
The advantages such as big application prospect.Pangolin, curcuma zedoary and dragon's blood in formula have effects that the Eradicates stasis of bloods, detumescence, analgesic therapy, radix semiaquilegiae, wood
Turtle, the seed of garden balsam, kelp and marine alga softening and resolving hard mass, the dried venom of toads have local anaesthesia, anti-inflammatory, analgesia function；By oozing for camphor and borneol
Saturating power, the easypro numbness dispersing paste that the present invention is provided is used to curing or alleviate mastitis, hyperplasia, caking etc. are common gynecological disease processes
In, there is excellent analgesic dissipating bind.
Therefore, the present invention provides following technical scheme：
In a first aspect, the present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：Radix semiaquilegiae 60~
150 parts by weight, the parts by weight of ground bettle 30~120, the parts by weight of camphor 20~60, the parts by weight of selfheal 40~160, the dried venom of toads 30~80
Parts by weight, the parts by weight of dragon's blood 30~80, the parts by weight of kelp 50~180, the parts by weight of borneol 15~50 and Malaysia glue 1300~
1600 parts by weight.Specifically, the Malaysia glue used in the present invention is purchased from Jining Chen Xing medical science and technologies Co., Ltd.
In the further embodiment of the present invention, in addition to：The parts by weight of semen momordicae 40~150, impetuous 30~100 weights
Measure part and the parts by weight of curcuma zedoary 60~160.
In the further embodiment of the present invention, in addition to：The parts by weight of pangolin 30~80 and the weight of marine alga 50~180
Measure part.
In the further embodiment of the present invention, including following raw material components：The parts by weight of radix semiaquilegiae 80~100, ground beetle
The parts by weight of worm 60~80, the parts by weight of camphor 20~30, the parts by weight of selfheal 70~100, the parts by weight of the dried venom of toads 60~80, dragon's blood 30~
50 parts by weight, the parts by weight of kelp 50~80, the parts by weight of borneol 15~30, the parts by weight of semen momordicae 80~120, impetuous 50~70 weights
Measure part, the parts by weight of curcuma zedoary 130~160, the parts by weight of pangolin 30~50, the parts by weight of marine alga 150~180 and the weight of Malaysia glue 1500
Measure part.
In the further embodiment of the present invention, marine alga includes the one or more in green alga, red algae and brown alga.Need
Illustrate, if select green alga, red algae and brown alga simultaneously, the mass ratio between three is preferably 3:2:1.
Second aspect, the present invention provides a kind of preparation method of easypro numbness dispersing paste, comprises the following steps：S101：By each original
Material component cleans, dry after crush, the raw material components in addition to dragon's blood, the dried venom of toads, camphor and borneol are well mixed afterwards, will be mixed
Product after closing uniformly is soaked in ethanol water, is filtered afterwards and is collected filtrate；S102：By Malaysia glue be heated to 55 DEG C~
65 DEG C, until Malaysia glue is completely melt, it is well mixed afterwards with the filtrate that S101 is obtained；S103：The production that S102 is prepared
Thing is heated and removes ethanol, and cooling afterwards is preserved, when temperature is reduced to 20 DEG C, is added dragon's blood and the dried venom of toads and is stirred；So
After camphor and borneol added when temperature is reduced to 5 DEG C and stir.It should be noted that being pointed out in S103：By S102 systems
Standby obtained product heats simultaneously remove ethanol, in ethanol process is removed, the product for preparing S102 can also be selected to lead to
Cross the method stood and remove ethanol, because ethanol highly volatile.
In the further embodiment of the present invention, step S104 is also included after S103：The product system that S103 is obtained
Into paste, the numbness dispersing paste that relaxes is obtained.
In the further embodiment of the present invention, in S101, the mass percentage concentration of ethanol water for 90%~
95%, and the addition of ethanol water is 3~5 of the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
Times；Soak time is 5~10 days.
The third aspect, the easypro numbness dispersing paste that the present invention is provided is preparing treatment mastitis, the proliferation of mammary gland and mammary gland caking
Application in medicine or medicated premix.
In the further embodiment of the present invention, the specifically used method of numbness of relaxing dispersing paste includes：With water and especially
Warm water cleans affected part, and easypro numbness dispersing paste is sticked afterwards, once a day, 3~8 hours every time.It should be noted that warm water is 25 DEG C
The water of left and right.
The above-mentioned technical proposal that the present invention is provided has advantages below：
(1) applicant has found by numerous studies：The easypro numbness dispersing paste that the present invention is provided, which is selected, contains active skull cap components
Plant be prepared from, prescription proportioning science, without any artificial synthesis group point, safe without toxic side effect, with instant effect,
Easy to operate, Small side effects, production cost are low and with advantages such as very big application prospects.Pangolin, curcuma zedoary and dragon's blood in formula
There is the Eradicates stasis of bloods, detumescence, analgesic therapy, radix semiaquilegiae, Mu Turtle, the seed of garden balsam, kelp and marine alga softening and resolving hard mass, the dried venom of toads have office
Fiber crops, anti-inflammatory, analgesia function；By camphor and the penetration of borneol, the easypro numbness dispersing paste that the present invention is provided is used to cure or alleviate
During mastitis, hyperplasia, caking etc. are common gynecological disease, there is excellent analgesic dissipating bind.
(2) the joyful discovery of applicant：The easypro numbness dispersing paste that the present invention is provided has instant effect, positive common medicine 3~6 hours
Can relief of symptoms, and may occur in which and significantly take a turn for the better using symptom at 3~5 days.
(3) preparation method provided using the present invention, the same of each bulk drug active component can be being retained to greatest extent
When, the active ingredient in each raw medicinal material can be fully discharged, so that the easypro numbness dispersing paste tool finally prepared
There is excellent effect；In addition, the stable preparation process of the present invention, yield are high, quality is good, energy consumption is low, raw material are extensive, process is simple
Single-unit is saved；Production can be completed using existing equipment, equipment requirement is reduced, so as to significantly reduce production cost.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
The embodiment to technical solution of the present invention is described in detail below.Following examples are only used for clearer
Explanation technical scheme, therefore be only used as example, and can not be limited the scope of the invention with this.
Experimental method in following embodiments, is conventional method unless otherwise specified.
Test material used, is to be commercially available from conventional reagent shop unless otherwise specified in following embodiments.
Quantitative test in following examples, is respectively provided with three repetition experiments, and data are the average value of three repetition experiments
Or mean+SD.
Radix semiaquilegiae used, the seed of garden balsam, semen momordicae, pangolin, curcuma zedoary, ground bettle, selfheal, elder brother in following embodiments
Cloth, dragon's blood, the dried venom of toads, camphor and borneol meet the pertinent regulations under each medicinal material of text of Chinese Pharmacopoeia (version in 2015).
Before feeding intake, by identification, ingredients material object is consistent with title, and quality meets standard.
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 60~150,
The parts by weight of ground bettle 30~120, the parts by weight of camphor 20~60, the parts by weight of selfheal 40~160, the parts by weight of the dried venom of toads 30~80, blood
Exhaust 30~80 parts by weight, the parts by weight of kelp 50~180, the parts by weight of borneol 15~50 and the parts by weight of Malaysia glue 1300~1600.
Preferably, in addition to：The parts by weight of semen momordicae 40~150, impetuous 30~100 parts by weight and curcuma zedoary 60~160
Parts by weight.
Preferably, in addition to：The parts by weight of pangolin 30~80 and the parts by weight of marine alga 50~180.Wherein, marine alga includes green
One or more in algae, red algae and brown alga.
In addition, the present invention is special to devise the method for preparing the numbness dispersing paste that relaxes, comprise the following steps：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in ethanol water, is filtered afterwards and is collected filtrate.Wherein,
The mass percentage concentration of ethanol water be 90%~95%, and ethanol water addition be except dragon's blood, the dried venom of toads, camphor and
3~5 times of raw material components gross mass outside borneol；Soak time is 5~10 days.
S102：Malaysia glue is heated to 55 DEG C~65 DEG C, until Malaysia glue is completely melt, the filtrate obtained afterwards with S101
It is well mixed.
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
Preferably, step S104 is also included after S103：Paste is made in the obtained products of S103, numbness dissipating bind of relaxing is obtained
Cream.
In addition, the present invention provides a kind of application method of easypro numbness dispersing paste：Affected part is cleaned with water, easypro numbness dissipating bind is sticked afterwards
Cream, once a day, 3~8 hours every time.It should be noted that for normal constitution person, when sticking easypro numbness dispersing paste, every time may be used
To continue 6~8 hours；For allergic constitution person, application time can be suitably reduced, continues 3~5 hours every time.
Illustrated with reference to embodiment：
Embodiment one
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 150, ground beetle
The parts by weight of worm 30, the parts by weight of camphor 60, the parts by weight of selfheal 40, the parts by weight of the dried venom of toads 80, the parts by weight of dragon's blood 30, the weight of kelp 180
Part, the parts by weight of borneol 15 and the parts by weight of Malaysia glue 1600.
By above-mentioned raw materials component, the preparation method of the easypro numbness dispersing paste provided using the present invention prepares the numbness dispersing paste that relaxes：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in the ethanol water that mass percentage concentration is 95%, afterwards
Filter and collect filtrate；The addition of ethanol water is the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
3 times；Soak time is 5 days.
S102：Malaysia glue is heated to 65 DEG C, until Malaysia glue is completely melt, mixed with the filtrate that S101 is obtained afterwards
It is even；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
S104：Paste is made in the obtained products of S103, the numbness dispersing paste that relaxes is obtained.
Embodiment two
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 100, ground beetle
The parts by weight of worm 60, the parts by weight of camphor 30, the parts by weight of selfheal 70, the parts by weight of the dried venom of toads 80, the parts by weight of dragon's blood 30, the weight of kelp 80
Part, the parts by weight of borneol 15 and the parts by weight of Malaysia glue 1500.
By above-mentioned raw materials component, the preparation method of the easypro numbness dispersing paste provided using the present invention prepares the numbness dispersing paste that relaxes：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in the ethanol water that mass percentage concentration is 90%, afterwards
Filter and collect filtrate；The addition of ethanol water is the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
3 times；Soak time is 10 days.
S102：Malaysia glue is heated to 55 DEG C, until Malaysia glue is completely melt, mixed with the filtrate that S101 is obtained afterwards
It is even；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
S104：Paste is made in the obtained products of S103, the numbness dispersing paste that relaxes is obtained.
Embodiment three
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 80, ground beetle
The parts by weight of worm 80, the parts by weight of camphor 20, the parts by weight of selfheal 100, the parts by weight of the dried venom of toads 60, the parts by weight of dragon's blood 50, the weight of kelp 50
Part, the parts by weight of borneol 30 and the parts by weight of Malaysia glue 1500.
By above-mentioned raw materials component, the preparation method of the easypro numbness dispersing paste provided using the present invention prepares the numbness dispersing paste that relaxes：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in the ethanol water that mass percentage concentration is 95%, afterwards
Filter and collect filtrate；The addition of ethanol water is the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
5 times；Soak time is 7 days.
S102：Malaysia glue is heated to 60 DEG C, until Malaysia glue is completely melt, mixed with the filtrate that S101 is obtained afterwards
It is even；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
S104：Paste is made in the obtained products of S103, the numbness dispersing paste that relaxes is obtained.
Example IV
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 100, ground beetle
The parts by weight of worm 60, the parts by weight of camphor 30, the parts by weight of selfheal 70, the parts by weight of the dried venom of toads 80, the parts by weight of dragon's blood 30, the weight of kelp 80
Part, the parts by weight of borneol 15, the parts by weight of semen momordicae 120, impetuous 50 parts by weight, the parts by weight of curcuma zedoary 160 and the weight of Malaysia glue 1500
Measure part.
By above-mentioned raw materials component, the preparation method of the easypro numbness dispersing paste provided using the present invention prepares the numbness dispersing paste that relaxes：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in the ethanol water that mass percentage concentration is 90%, afterwards
Filter and collect filtrate；The addition of ethanol water is the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
3 times；Soak time is 10 days.
S102：Malaysia glue is heated to 55 DEG C, until Malaysia glue is completely melt, mixed with the filtrate that S101 is obtained afterwards
It is even；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
S104：Paste is made in the obtained products of S103, the numbness dispersing paste that relaxes is obtained.
Embodiment five
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 80, ground beetle
The parts by weight of worm 80, the parts by weight of camphor 20, the parts by weight of selfheal 100, the parts by weight of the dried venom of toads 60, the parts by weight of dragon's blood 50, the weight of kelp 50
Part, the parts by weight of borneol 30, the parts by weight of semen momordicae 80, impetuous 70 parts by weight, the parts by weight of curcuma zedoary 130 and the weight of Malaysia glue 1500
Part.
By above-mentioned raw materials component, the preparation method of the easypro numbness dispersing paste provided using the present invention prepares the numbness dispersing paste that relaxes：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in the ethanol water that mass percentage concentration is 95%, afterwards
Filter and collect filtrate；The addition of ethanol water is the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
5 times；Soak time is 7 days.
S102：Malaysia glue is heated to 60 DEG C, until Malaysia glue is completely melt, mixed with the filtrate that S101 is obtained afterwards
It is even；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
S104：Paste is made in the obtained products of S103, the numbness dispersing paste that relaxes is obtained.
Embodiment six
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 100, ground beetle
The parts by weight of worm 60, the parts by weight of camphor 30, the parts by weight of selfheal 70, the parts by weight of the dried venom of toads 80, the parts by weight of dragon's blood 30, the weight of kelp 80
Part, the parts by weight of borneol 15, the parts by weight of semen momordicae 120, impetuous 50 parts by weight, the parts by weight of curcuma zedoary 160, the parts by weight of pangolin 50,
The parts by weight of red algae 150 and the parts by weight of Malaysia glue 1500.
By above-mentioned raw materials component, the preparation method of the easypro numbness dispersing paste provided using the present invention prepares the numbness dispersing paste that relaxes：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in the ethanol water that mass percentage concentration is 90%, afterwards
Filter and collect filtrate；The addition of ethanol water is the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
3 times；Soak time is 10 days.
S102：Malaysia glue is heated to 55 DEG C, until Malaysia glue is completely melt, mixed with the filtrate that S101 is obtained afterwards
It is even；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
S104：Paste is made in the obtained products of S103, the numbness dispersing paste that relaxes is obtained.
Embodiment seven
The present invention provides a kind of easypro numbness dispersing paste, raw material components by weight, including：The parts by weight of radix semiaquilegiae 80, ground beetle
The parts by weight of worm 80, the parts by weight of camphor 20, the parts by weight of selfheal 100, the parts by weight of the dried venom of toads 60, the parts by weight of dragon's blood 50, the weight of kelp 50
It is part, the parts by weight of borneol 30, the parts by weight of semen momordicae 80, impetuous 70 parts by weight, the parts by weight of curcuma zedoary 130, the parts by weight of pangolin 30, green
The parts by weight of algae 90, the parts by weight of red algae 60, the parts by weight of brown alga 30 and the parts by weight of Malaysia glue 1500.
By above-mentioned raw materials component, the preparation method of the easypro numbness dispersing paste provided using the present invention prepares the numbness dispersing paste that relaxes：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the original in addition to dragon's blood, the dried venom of toads, camphor and borneol
Expect that component is well mixed, the product after being well mixed is soaked in the ethanol water that mass percentage concentration is 95%, afterwards
Filter and collect filtrate；The addition of ethanol water is the raw material components gross mass in addition to dragon's blood, the dried venom of toads, camphor and borneol
5 times；Soak time is 7 days.
S102：Malaysia glue is heated to 60 DEG C, until Malaysia glue is completely melt, mixed with the filtrate that S101 is obtained afterwards
It is even；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
S104：Paste is made in the obtained products of S103, the numbness dispersing paste that relaxes is obtained.
In addition, the easypro numbness dispersing paste that various embodiments of the present invention are obtained, by function assessment experiment come its effect of system evaluation：
First, toxicity test
The non-pregnant rat 70 of wistar females that body weight is 180~200g is selected, is divided into 7 groups, the gavage present invention is implemented respectively
The easypro numbness dispersing paste that example one to embodiment seven is prepared, dosage is 1g/kg, successive administration 7 days.During administration and it is discontinued
Afterwards 1 week when, observation Growth in Rats state and activity and diet, identification hematology, blood biochemical analysis, organ tissue structure and urine are normal
Rule etc..As a result the health existence of all rats is found, it is without any side effects；Anatomic observation blood picture, liver function, each organs and tissues
State, is compared indifference with normal rat.It is demonstrated experimentally that the easypro numbness dispersing paste that the present invention is provided is nontoxic, it is safe and reliable when using.
2nd, for the therapeutic action of rat mammary gland hyperplasia disease
The non-pregnant rat 90 of wistar females that body weight is 180~200g is selected, is divided into 9 groups, every group 10.Wherein, first
Group is blank control group, and the 2nd group is model control group, and the 3rd~9 group is experimental group.In addition to blank control group, each group uses benzene
Formic acid estradiol 0.5mg/kg intramuscular injections 25 days, then use progesterone 4mg/kg intramuscular injection 5 days instead, prepare rat mammary gland
Model of hyperplasia.Wherein, oestradiol benzoate and progesterone are commercially available prod.In order to observe the prevention and treatment to cyclomastopathy
Effect, gavages easypro numbness dispersing paste of the embodiment one into embodiment seven to the 3rd~9 group, one time a day respectively after modeling success
5mg/kg；Model group and blank control group gavage 5ml/kg physiological saline with method.30th day clip chest, second pair of breast after administration
Room, slide measure accurately measures the breast diameter of left and right two, height and papilla diameter, specific as shown in table 1；Breast is entered afterwards
Enter under Fuding in 10% formalin solution, specimens paraffin embedding slices hematoxylin eosin staining, mirror to mammary gland alveolus, conduit and interstitial
Hyperplasia degree scored respectively, three's scoring accumulated value is proliferation of mammary gland degree, and calculates proliferation of mammary gland rate.Normally：
(-), 1 point；Slight hyperplasia：(+), 2 points：Moderate hyperplasia：(++), 3 points；Severe hyperplasia (+++), it is 4 points, specific as shown in table 2.
Easypro therapeutic action list one of the numbness dispersing paste to rat mammary gland hyperplasia disease of each embodiment of table 1
Easypro therapeutic action list two of the numbness dispersing paste to rat mammary gland hyperplasia disease of each embodiment of table 2
3rd, clinical test
The call-up age female patient of 25~60 years old 700, each patient is accompanied by different degrees of mastosis, small swollen
Block, breast low-heat, there is tenderness and the symptom such as itch often.Patient is divided into 7 groups, every group 100, first group to the 7th group
The easypro numbness dispersing paste of the embodiment of the present invention one and embodiment seven on probation 1 week, observes and records the curative effect symptom of each patient respectively.Its
In, curative effect situation criterion is, effective：Mastosis, small lump, breast low-heat, there is tenderness and the symptom such as itch often
Significantly improve；Effectively：Mastosis, small lump, breast low-heat, there is tenderness and the symptom such as itch often makes moderate progress；It is invalid：
Mastosis, small lump, breast low-heat, there is tenderness and the symptom such as itch often remains unchanged substantially.As a result it is as shown in table 3.
Specifically used method is：Affected part is cleaned with warm water, the easypro numbness dispersing pastes of 5g are sticked afterwards, once a day, 6 is small every time
When.
The clinical efficacy statistical form of the easypro numbness dispersing paste of each embodiment of table 3
| Effective/name | Effectively/name | Invalid/name | |
| Embodiment one | 73 | 25 | 2 |
| Embodiment two | 75 | 22 | 3 |
| Embodiment three | 75 | 23 | 2 |
| Example IV | 83 | 16 | 1 |
| Embodiment five | 85 | 15 | 0 |
| Embodiment six | 95 | 15 | 0 |
| Embodiment seven | 93 | 7 | 0 |
Certainly, except the situation that embodiment one is enumerated to embodiment seven, the species and percentage by weight of other raw material components,
Preparation condition etc. is also possible.
The easypro numbness dispersing paste that the present invention is provided is prepared from from the plant containing active skull cap components, prescription proportioning section
Learn, without any artificial synthesis group point, safe without toxic side effect, with instant effect, easy to operate, Small side effects, production cost
It is low and with the advantage such as very big application prospect.Pangolin, curcuma zedoary and dragon's blood in formula have effects that the Eradicates stasis of bloods, detumescence, analgesic therapy,
Radix semiaquilegiae, Mu Turtle, the seed of garden balsam, kelp and marine alga softening and resolving hard mass, the dried venom of toads have local anaesthesia, anti-inflammatory, analgesia function；By camphor and
The penetration of borneol, the easypro numbness dispersing paste that provides of the present invention is used to curing or alleviate mastitis, hyperplasia, caking etc. are that gynaecology is common
During disease, there is excellent analgesic dissipating bind.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not
It is interpreted as indicating or implies relative importance or the implicit quantity for indicating indicated technical characteristic.Thus, define " the
One " ,~individual or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means to combine specific features, structure, material or the spy that the embodiment or example are described
Point is contained at least one embodiment of the present invention or example.In this manual, to the schematic representation of above-mentioned term not
Identical embodiment or example must be directed to.Moreover, specific features, structure, material or the feature of description can be with office
Combined in an appropriate manner in one or more embodiments or example.In addition, in the case of not conflicting, the skill of this area
Art personnel can be tied the not be the same as Example or the feature of example and non-be the same as Example or example described in this specification
Close and combine.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changed, replacing and modification.
Claims (10)
1. a kind of easypro numbness dispersing paste, it is characterised in that raw material components by weight, including：
The parts by weight of radix semiaquilegiae 60~150, the parts by weight of ground bettle 30~120, the parts by weight of camphor 20~60, the weight of selfheal 40~160
Measure part, the parts by weight of the dried venom of toads 30~80, the parts by weight of dragon's blood 30~80, the parts by weight of kelp 50~180, the parts by weight of borneol 15~50 and
The parts by weight of Malaysia glue 1300~1600.
2. easypro numbness dispersing paste according to claim 1, it is characterised in that also include：
The parts by weight of semen momordicae 40~150, impetuous 30~100 parts by weight and the parts by weight of curcuma zedoary 60~160.
3. easypro numbness dispersing paste according to claim 2, it is characterised in that also include：
The parts by weight of pangolin 30~80 and the parts by weight of marine alga 50~180.
4. easypro numbness dispersing paste according to claim 3, it is characterised in that including following raw material components：
The parts by weight of radix semiaquilegiae 80~100, the parts by weight of ground bettle 60~80, the parts by weight of camphor 20~30, the weight of selfheal 70~100
Part, the parts by weight of the dried venom of toads 60~80, the parts by weight of dragon's blood 30~50, the parts by weight of kelp 50~80, the parts by weight of borneol 15~30, semen momordicae
80~120 parts by weight, impetuous 50~70 parts by weight, the parts by weight of curcuma zedoary 130~160, the parts by weight of pangolin 30~50, marine alga
150~180 parts by weight and the parts by weight of Malaysia glue 1500.
5. easypro numbness dispersing paste according to claim 4, it is characterised in that：
The marine alga includes the one or more in green alga, red algae and brown alga.
6. the preparation method of any one of Claims 1 to 5 easypro numbness dispersing paste, it is characterised in that comprise the following steps：
S101：Crushed after each raw material components are cleaned, dried, afterwards by the raw material group in addition to dragon's blood, the dried venom of toads, camphor and borneol
Divide well mixed, the product after described be well mixed is soaked in ethanol water, filters afterwards and collects filtrate；
S102：Malaysia glue is heated to 55 DEG C~65 DEG C, until the Malaysia glue is completely melt, obtained afterwards with the S101
Filtrate is well mixed；
S103：By the S102 product heats prepared and ethanol is removed, cooling afterwards is preserved, and treats that temperature is reduced to 20 DEG C
When, add dragon's blood and the dried venom of toads and stir；Then camphor and borneol are added when temperature is reduced to 5 DEG C and is stirred.
7. the preparation method of the easypro numbness dispersing paste described in claim 6, it is characterised in that：
Also include step S104 after the S103：Paste is made in the obtained products of the S103, the easypro numbness dissipating bind is obtained
Cream.
8. the preparation method of the easypro numbness dispersing paste described in claim 6, it is characterised in that：
In the S101, the mass percentage concentration of the ethanol water is 90%~95%, and the ethanol water plus
Enter 3~5 times of raw material components gross mass of the amount for described in addition to dragon's blood, the dried venom of toads, camphor and borneol；Soak time is 5~10
My god.
9. any one of Claims 1 to 5 easypro numbness dispersing paste is preparing treatment mastitis, the proliferation of mammary gland and mammary gland caking medicine
Application in thing or medicated premix.
10. application according to claim 9, it is characterised in that：
Affected part is cleaned with water, the easypro numbness dispersing paste, once a day, 3~8 hours every time are sticked afterwards.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710353742.6A CN107050393A (en) | 2017-05-18 | 2017-05-18 | Numbness of relaxing dispersing paste and preparation method and application |
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| CN201710353742.6A CN107050393A (en) | 2017-05-18 | 2017-05-18 | Numbness of relaxing dispersing paste and preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991536A (en) * | 2020-08-28 | 2020-11-27 | 林国成 | Traditional Chinese medicine formula for treating mastitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1164414A (en) * | 1997-04-25 | 1997-11-12 | 李文明 | Traditional Chinese medicine plaster for treatment of mastosis |
-
2017
- 2017-05-18 CN CN201710353742.6A patent/CN107050393A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1164414A (en) * | 1997-04-25 | 1997-11-12 | 李文明 | Traditional Chinese medicine plaster for treatment of mastosis |
Non-Patent Citations (1)
| Title |
|---|
| 刘志媛等编著: "《海藻生物技术》", 31 July 2015, 海洋出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991536A (en) * | 2020-08-28 | 2020-11-27 | 林国成 | Traditional Chinese medicine formula for treating mastitis and preparation method thereof |
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Application publication date: 20170818 |