CN101991788A - Preparation with effects of clearing heat and detoxicating, and diminishing swelling and relieving pain and preparation method thereof - Google Patents

Preparation with effects of clearing heat and detoxicating, and diminishing swelling and relieving pain and preparation method thereof Download PDF

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CN101991788A
CN101991788A CN2009101836556A CN200910183655A CN101991788A CN 101991788 A CN101991788 A CN 101991788A CN 2009101836556 A CN2009101836556 A CN 2009101836556A CN 200910183655 A CN200910183655 A CN 200910183655A CN 101991788 A CN101991788 A CN 101991788A
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parts
preparation
calculus bovis
powder
fine powder
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汤明昌
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Abstract

The invention provides a preparation with the effects of clearing heat and detoxicating, and diminishing swelling and relieving pain and a preparation method thereof. The preparation is characterized by being prepared from the following components in part by weight: 1 to 2 parts of in-vitro cultivated calculus bovis, 4 to 8 parts of artificial musk, 30 to 35 parts of frankincense, 30 to 35 parts of myrrh, 15 to 20 parts of realgar and 15 to 20 parts of glutinous millet. Due to medicine grinding technology and a mixing method provided by the invention, the problem of grinding of the frankincense and the myrrh is well solved, the technical scheme of mixing medicines with different specific gravity and different content is well provided, the curative effect of a product can be enhanced, and the side reaction of the product is reduced.

Description

A kind of preparation and preparation method with heat-clearing and toxic substances removing and reducing swelling and alleviating pain function
Technical field
The invention provides a kind of preparation, belong to the technical field that Chinese medicine is made with heat-clearing and toxic substances removing and reducing swelling and alleviating pain function.
Background technology
Carbuncle carbuncle on the back: the heavier person who is meant the living carbuncle in back.
Scrofula is a kind of infectious surgical diseases of being born in cervical region.How to be divided into acute, chronic two classes now by incidence.Acute many because of affection due to external wind and heat, in accumulate the expectorant poison and send out genus cervical carbuncle (acute festering type disease between the cervical region skin) scope; Chronic many wound because of the stagnation of QI, void sends out, and is the present scrofula of indication clinically, is equivalent to the tuberculous lymphadenitis of doctor trained in Western medicine.
Multiple abscess is with the transitivity that occurs in deep part of muscle, the systemic infection disease that multiple abscess is performance.The pyemia, the deep part of muscle abscess that are equivalent to doctor trained in Western medicine.
Acute mastitis refers to acute mastitis.
Breast carcinoma is cyclomastopathy or mammary gland abnormity hypertrophy (being breast carcinoma).
Innominate toxic swelling: the traditional Chinese medical science refers to the skin infection that all can not claim name.
Preparation provided by the invention is to treat the carbuncle carbuncle on the back, scrofula multiple abscess, acute mastitis breast carcinoma, the Chinese patent medicine of innominate toxic swelling disease.
To carbuncle carbuncle on the back, scrofula multiple abscess, acute mastitis breast carcinoma, innominate toxic swelling treatment of diseases, belong to bacterial infection person, common antibiotics symptomatic treatment; Belong to cyclomastopathy person, hormone therapy commonly used; The patient who belongs to cancerous protuberance, anti-tumor drug treatment commonly used.In all existing western medical treatment schemes, it is very sure to be of no curative effect.Chinese patent medicine is provided by the another kind of approach that provides in this respect, and the awake ball (tablet, capsule) that disappears of Calculus Bovis is one of classical medicine wherein.
The awake ball that disappears of Calculus Bovis is a Chinese patent medicine with a long history; acute mastitis breast carcinoma, scrofula multiple abscess had curative effect preferably; but recently ten years is difficult in the hospital and has bought, and main cause is: raw material is very rare, and technology of preparing is difficult to reach that " Chinese pharmacopoeia is to the preparation requirement of pill.The awake ball that disappears of Calculus Bovis is made by Calculus Bovis, Moschus, Olibanum, Myrrha, Realgar, Semen setariae.Because the Moschus resource is day by day withered; the woods Moschus moschiferous is classified animals under first-class state protection as and forbids killing; be difficult to the natural Moschus and made the awake ball that disappears of Calculus Bovis; through State Administration of Traditional Chinese Medicine and the approval of food and medicine Surveillance Authority; use the artificial Moschus to substitute the natural Moschus; content among the artificial Moschus among muscone content and the natural Moschus is approaching, and curative effect and natural Moschus are approaching, is accepted by numerous doctors, pharmacist and patient with the Chinese patent medicine that the artificial Moschus makes.The natural Calculus Bovis resource is very rare; can not satisfy the demand in pharmacy market; a lot of pharmacy corporations use the artificial Calculus Bovis to substitute natural Calculus Bovis; but artificial Calculus Bovis and natural Calculus Bovis quality differ greatly; with regard to existing quality standard; active ingredient bilirubin in the natural Calculus Bovis be among the artificial Calculus Bovis more than 3 times; " Chinese pharmacopoeia 2005 version (an one) limits and can not surpass 0.7% the unconjugated bilirubin in the natural Calculus Bovis; it mainly is the toxic reaction of unconjugated bilirubin; vomiting can appear after the patient took; untoward reaction such as jaundice; and free content of bilirubin is too high among the artificial Calculus Bovis, and its content is not limited in the working standard.Obviously, substitute the curative effect that natural Calculus Bovis can not guarantee the awake ball that disappears of Calculus Bovis with the artificial Calculus Bovis.
The present invention uses In vitro cultured Calculus Bovis to substitute natural Calculus Bovis.
The In vitro cultured Calculus Bovis that the present invention uses is the crude drug that obtains State Food and Drug Administration's approval registration, has perfect quality standard.In vitro cultured Calculus Bovis is the lithogenous biochemical process of mock bull body inner bag; the Calculus Bovis of in external Fel Bovis seu Bubali, developing; its character, surface structure, microstructure, composition, content are all consistent with the high-quality natural Calculus Bovis; steady quality, controlled; do not contain Hyodeoxycholic Acid; can carry out suitability for industrialized production, just in time remedy the deficiency of natural Calculus Bovis.The one-tenth stone process of In vitro cultured Calculus Bovis is Biochemical processes, is the process that various effective ingredient, effective group make up naturally.1997, In vitro cultured Calculus Bovis obtained national Chinese medicine one kind new medicine certificate, and 2002, the research achievement obtained national technological invention second prize.Expert through Chinese Pharmacopoeia Commission's tissue repeatedly proves: the shape of In vitro cultured Calculus Bovis, structure, composition, content are all similar to natural Calculus Bovis; pharmacodynamics, toxicologic study result prove safety; clinical efficacy is consistent with natural Calculus Bovis; and being higher than natural Calculus Bovis for some sick curative effect of planting, is the ideal substitute of natural Calculus Bovis.The quality standard of In vitro cultured Calculus Bovis is by " Chinese pharmacopoeia version in 2005 is recorded.
State Food and Drug Administration successively holds expert discussion on Wuhan, Beijing and other places, and whether alternative natural Calculus Bovis has carried out discussing again and again with Calculus Bovis cultivating to In vitro cultured Calculus Bovis.Detection to the multiple one-tenth such as content of bilirubin of In vitro cultured Calculus Bovis shows; In vitro cultured Calculus Bovis can substitute natural Calculus Bovis fully; State Food and Drug Administration is according to expert's conclusion, and decision can use 41 kinds of emergency and severe disease medications such as cow-bezoar bolus for resurrections In vitro cultured Calculus Bovis, Calculus Bovis cultivating to substitute.To solve this problem of Calculus Bovis insufficient raw material.The cultivation success of In vitro cultured Calculus Bovis will make more common people can benefit from the medicinal efficacy of Calculus Bovis.
On January 31st, 2004, State Food and Drug Administration sends " about the notice of Calculus Bovis and succedaneum use problem thereof ": for the new drug that contains Calculus Bovis of clinical anxious severe disease disease medicine variety that contains Calculus Bovis in the national drug standards prescription and the approval of national drug supervisory and management department, Calculus Bovis in the prescription can be substituted uses that feed intake of Calculus Bovis equivalent with Calculus Bovis cultivating, In vitro cultured Calculus Bovis, but it is alternative not to be able to the artificial Calculus Bovis; Other kinds that contain Calculus Bovis can substitute the use that feeds intake of Calculus Bovis equivalent with Calculus Bovis cultivating, In vitro cultured Calculus Bovis or artificial Calculus Bovis with the Calculus Bovis in the prescription.The scope of application to the artificial Calculus Bovis of this document limits, and can be equal to use with natural Calculus Bovis to In vitro cultured Calculus Bovis, also is the affirming of quality, drug effect, clinical efficacy to In vitro cultured Calculus Bovis.
There are a lot of defectives in the technology of preparing of the awake oral preparation for eliminating of existing Calculus Bovis; Olibanum, Myrrha can not be pulverized effectively, and the granule after the pulverizing is too thick, can not cross 120 mesh sieves; can cause the powder mixes of In vitro cultured Calculus Bovis, artificial Moschus and Realgar insufficient like this, cause the dispersion of medicine defective.Technical scheme provided by the invention is: after concocting Olibanum, Myrrha, drying under reduced pressure to remove moisture, cooling back Olibanum, Myrrha become crisp, and the reuse ball mill is ground into coarse powder; The fine powder of Realgar fine powder and Semen setariae mixed with the equivalent incremental method grinds, more all fine powders are pulverized with freezing crusher, like this by pulverize, grinding, can be the pulverizing of Olibanum, Myrrha 120 mesh sieves, the difficult problem with the dispersion of Realgar has solved simultaneously.
Because it is expensive that In vitro cultured Calculus Bovis and artificial Moschus measure few valency, with the very difficult mix homogeneously of the powder of Olibanum, Myrrha, the method that the present invention adopts equivalent to increase progressively is mixed, and mixes with ball mill and grinds, and can guarantee that not only the granule of mix homogeneously but also medicine is thinner.Because the effect of heating is arranged in the ball mill grinding process, cause the mixture difficulty of sieving, the technical scheme that we solve is: the mixture behind the ball mill grinding is left in-18 ℃ the environment cold preservation after 12 hours after sieve, powder has 98% mistake 120 mesh sieves.
Because the granule of mixed material is very thin, in the room temperature storage, Olibanum, Myrrha are bonding easily again, and the material that processes (semi-finished product) is placed on that cold preservation can solve this difficult problem well in-18 ℃ the environment.
Because waking up, Calculus Bovis contains a large amount of Olibanums, Myrrha fine powder in the oral preparation for eliminating; be prepared into the process that extruding, heating are arranged behind the pill (tablet, capsule); cause medicated powder bonding again; the disintegration of medicine can not reach " the requirement of Chinese pharmacopoeia; this technical barrier causes a lot of enterprises not produce or the consumption of Olibanum, Myrrha is reduced, and produces the underproof medicine of content.Technical scheme provided by the invention is: sneak into 3% HPMC of medicated powder weight in semi-finished product, technical barrier that can fine solution medicine disintegration.
Summary of the invention
Purpose of the present invention is to select In vitro cultured Calculus Bovis for use, uses suitable process technology scheme, is prepared into a kind of preparation with heat-clearing and toxic substances removing and reducing swelling and alleviating pain function.
The present invention constitutes like this, calculates according to composition by weight, is made for 15~20 parts by 1~2 part of In vitro cultured Calculus Bovis, 4~8 parts of artificial Moschuss, 30~35 parts of Olibanums, 30~35 parts of Myrrhas, 15~20 parts of Realgars, Semen setariae.
Specifically, calculate according to composition by weight: it is made for 16 parts by 1 part of In vitro cultured Calculus Bovis, 5 parts of artificial Moschuss, 33.3 parts of Olibanums, 33.3 parts of Myrrhas, 16.7 parts of Realgars, Semen setariae.
Preparation of the present invention is pill, tablet or capsule.
The preparation method of preparation of the present invention is:
The first step: Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill;
Second step: get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby;
The 3rd step: the artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding; increase progressively with equivalent in the powder of mixing method adding second step acquisition; grind well with ball mill; sealing was left in-18 ℃ the refrigerator 12 hours, crossed 120 mesh sieves, added the HPMC of drug powder weight 3% again; manual mixing; leave in-18 ℃ the refrigerator, take out in the preparation, be prepared into pill, tablet or capsule according to conventional method.
Pill of the present invention is preparation like this:
The first step: Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill;
Second step: get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby;
The 3rd step: the artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding; increase progressively with equivalent in the powder of mixing method adding second step acquisition; grind well with ball mill; sealing was left in-18 ℃ the refrigerator 12 hours, crossed 120 mesh sieves, added the HPMC of drug powder weight 3% again; manual mixing; leave in-18 ℃ the refrigerator, take out in the preparation, make pill according to the manufacture method of pill.
Capsule of the present invention is preparation like this:
The first step: Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill;
Second step: get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby;
The 3rd step: the artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding; increase progressively mixing method with equivalent and add in the powder that second step obtained, grind well with ball mill, sealing was left in-18 ℃ the refrigerator 12 hours; cross 120 mesh sieves; the HPMC that adds drug powder weight 3% again, manual mixing leaves in-18 ℃ the refrigerator; take out in the preparation; sneak into a spot of lubricant, filled capsules is made capsule.
Described tablet is preparation like this:
The first step: Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill;
Second step: get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby;
The 3rd step: the artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding; increase progressively mixing method with equivalent and add in the powder that second step obtained, grind well with ball mill, sealing was left in-18 ℃ the refrigerator 12 hours; cross 120 mesh sieves; the HPMC that adds drug powder weight 3% again, manual mixing leaves in-18 ℃ the refrigerator; take out in the preparation; add a spot of lubricant, tabletting is made tablet.
Concrete embodiment
Embodiment 1:
Get Calculus Bovis 6g, Moschus 30g, Olibanum 200g, Myrrha 200g, Realgar 100g, Semen setariae 100g, Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill; Get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby; The artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding; increasing progressively mixing method with equivalent adds in the mixed powder that grinds of Olibanum, Myrrha, Realgar and Semen setariae; grind well with ball mill, sealing was left in-18 ℃ the refrigerator 12 hours, crossed 120 mesh sieves; the HPMC that adds drug powder weight 3% again; manual mixing leaves in-18 ℃ the refrigerator, takes out in the preparation; manufacture method according to pill is made pill, every bottled 3g.
Embodiment 2:
Get Calculus Bovis 6g, Moschus 30g, Olibanum 200g, Myrrha 200g, Realgar 100g, Semen setariae 100g, Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill; Get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby; The artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding, increase progressively mixing method with equivalent and add in the mixed powder that grinds of Olibanum, Myrrha, Realgar and Semen setariae, grind well with ball mill; sealing was left in-18 ℃ the refrigerator 12 hours; cross 120 mesh sieves, add the HPMC of drug powder weight 3% again, manual mixing; leave in-18 ℃ the refrigerator; take out in the preparation, sneak into a spot of lubricant, filled capsules; make capsule, the heavy 0.5g of every capsules.
Embodiment 3:
Get Calculus Bovis 6g, Moschus 30g, Olibanum 200g, Myrrha 200g, Realgar 100g, Semen setariae 100g, Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill; Get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby; The artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding, increase progressively mixing method with equivalent and add in the mixed powder that grinds of Olibanum, Myrrha, Realgar and Semen setariae, grind well with ball mill; sealing was left in-18 ℃ the refrigerator 12 hours; cross 120 mesh sieves, add the HPMC of drug powder weight 3% again, manual mixing; leave in-18 ℃ the refrigerator; take out in the preparation, add a spot of lubricant, tabletting; make tablet, every heavy 0.5g of tablet.

Claims (5)

1. preparation with heat-clearing and toxic substances removing and reducing swelling and alleviating pain function; it is characterized in that: calculate according to composition by weight, make for 15~20 parts by 1~2 part of In vitro cultured Calculus Bovis, 4~8 parts of artificial Moschuss, 30~35 parts of Olibanums, 30~35 parts of Myrrhas, 15~20 parts of Realgars, Semen setariae.
2. according to the described preparation of claim 1, it is characterized in that: calculate according to composition by weight, make for 16 parts by 1 part of In vitro cultured Calculus Bovis, 5 parts of artificial Moschuss, 33.3 parts of Olibanums, 33.3 parts of Myrrhas, 16.7 parts of Realgars, Semen setariae.
3. according to claim 1 or 2 described preparations, it is characterized in that: described preparation is pill, tablet or capsule.
4. the preparation method of 1~3 described each described preparation as requested is characterized in that:
The first step: Olibanum, Myrrha are concocted with red vinegar, made thinner in stainless steel disc, drying under reduced pressure 3 hours (baking temperature: 60 ℃), spreading for cooling grinds into coarse powder to room temperature with ball mill;
Second step: get Semen setariae and cook (the saturating heart),, be ground into fine powder in 80 ℃ of oven dry (water content is less than 5%); Realgar is ground to form impalpable powder; The method that the fine powder of Realgar is increased progressively according to equivalent adds to mix in the fine powder of Semen setariae grinds.The coarse powder of mixed fine powder with Olibanum, Myrrha mixed, and sealing was left in-18 ℃ the refrigerator 12 hours, pulverized with freezing crusher immediately after the taking-up, crossed 120 mesh sieves, and is standby;
The 3rd step: the artificial Moschus is become fine powder with the In vitro cultured Calculus Bovis mixed grinding; increase progressively with equivalent in the powder of mixing method adding second step acquisition; grind well with ball mill; sealing was left in-18 ℃ the refrigerator 12 hours, crossed 120 mesh sieves, added the HPMC of drug powder weight 3% again; manual mixing; leave in-18 ℃ the refrigerator, take out in the preparation, be prepared into pill, tablet or capsule according to conventional method.
5. according to the described preparation of claim 4, it is characterized in that: have the function of heat-clearing and toxic substances removing and reducing swelling and alleviating pain, can be used for treating the disease of carbuncle carbuncle on the back, scrofula multiple abscess, acute mastitis breast carcinoma, innominate toxic swelling.
CN2009101836556A 2009-08-14 2009-08-14 Preparation with effects of clearing heat and detoxicating, and diminishing swelling and relieving pain and preparation method thereof Pending CN101991788A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014206093A1 (en) * 2013-06-26 2014-12-31 上海中医药大学 Chinese herbal compound anti-tumour nanopreparation and use thereof
CN104888146A (en) * 2015-06-30 2015-09-09 叶学忠 Anti-cancer Chinese herbal medicine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014206093A1 (en) * 2013-06-26 2014-12-31 上海中医药大学 Chinese herbal compound anti-tumour nanopreparation and use thereof
CN104888146A (en) * 2015-06-30 2015-09-09 叶学忠 Anti-cancer Chinese herbal medicine

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Open date: 20110330