CN101991659A - Preparation with functions of clearing heat and releasing toxin and preparation method - Google Patents
Preparation with functions of clearing heat and releasing toxin and preparation method Download PDFInfo
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- CN101991659A CN101991659A CN2009101840157A CN200910184015A CN101991659A CN 101991659 A CN101991659 A CN 101991659A CN 2009101840157 A CN2009101840157 A CN 2009101840157A CN 200910184015 A CN200910184015 A CN 200910184015A CN 101991659 A CN101991659 A CN 101991659A
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Abstract
The invention provides a preparation formula which has functions of clearing heat and releasing toxin and a preparation method. The preparation is prepared by the following steps in part by weight: 1 to 2 parts of in vitro cultured calculus bovis, 8 to 12 parts of realgar, 35 to 45 parts of gypsum, 35 to 45 parts of rhubarb, 25 to 35 parts of scutellaria, 15 to 25 parts of balloon flower, 3 to 6 parts of borneol and 8 to 12 parts of liquorice. Compared with the prior art, the preparation of the invention has lower toxic and side effects, more exact curative efficiency and a more reasonable preparation process.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of heat-clearing and toxic substances removing, belong to the field of Chinese patent medicine technology of preparing.
Background technology
With regard to present medical technology, gingival swelling and pain, aphtha of the mouth and tongue, conjunctival congestion and swelling pain there is no drug treatment very effective and that suit the medicine to the illness, Therapeutic Method such as main employing antibiotic, and these methods have obvious defects, antibiotic is abused in a large number, causes the pathogenic bacteria drug resistance to increase greatly, and the whole immune system of human body is wrecked, be easy to cause the generation of complication, infect complication at last and death.Use symptoms such as Chinese patent drugs for treatment gingival swelling and pain, aphtha of the mouth and tongue, conjunctival congestion and swelling pain to have the characteristics of reliable curative effect and few side effects.
The preparation prescription that the present invention relates to derives from the detoxicating tablet of cow-bezoar of Chinese patent medicine ministry standard; be made up of following prescription: Calculus Bovis, Realgar, Gypsum Fibrosum, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Platycodonis, Borneolum Syntheticum, Radix Glycyrrhizae are the classics prescriptions of part of the body cavity above the diaphragm housing the heart and lungs excess-heat symptoms such as the burning hot interior Sheng of Chinese traditional treatment, laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue, conjunctival congestion and swelling pain.Because Calculus Bovis is very rare in the prescription, a lot of pharmacy corporations use the artificial Calculus Bovis to substitute natural Calculus Bovis, and artificial Calculus Bovis and natural Calculus Bovis have very big difference at preparation method and method of quality control, and artificial Calculus Bovis's the curative effect and the curative effect of natural Calculus Bovis have very big difference.The present invention selects In vitro cultured Calculus Bovis to replace natural Calculus Bovis among the former side.According to the file of State Food and Drug Administration approval, In vitro cultured Calculus Bovis can substitute with dosage such as natural Calculus Bovis and use.The antiphlogistic bezoar preparation with the alternative natural Calculus Bovis of In vitro cultured Calculus Bovis that the present invention relates to still has the function of heat-clearing and toxic substances removing, can be used for the treatment of the clinical symptoms of burning hot interior Sheng, laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue, conjunctival congestion and swelling pain.
The In vitro cultured Calculus Bovis that the present invention uses is the crude drug that obtains State Food and Drug Administration's approval registration, has perfect quality standard.In vitro cultured Calculus Bovis is the lithogenous biochemical process of mock bull body inner bag; the Calculus Bovis of in external Fel Bovis seu Bubali, developing; its character, surface structure, microstructure, composition, content are all consistent with the high-quality natural Calculus Bovis; steady quality, controlled; do not contain Hyodeoxycholic Acid; can carry out suitability for industrialized production, just in time remedy the deficiency of natural Calculus Bovis.The one-tenth stone process of In vitro cultured Calculus Bovis is Biochemical processes, is the process that various effective ingredient, effective group make up naturally.1997, In vitro cultured Calculus Bovis obtained national Chinese medicine one kind new medicine certificate, and 2002, the research achievement obtained national technological invention second prize.Expert through Chinese Pharmacopoeia Commission's tissue repeatedly proves: the shape of In vitro cultured Calculus Bovis, structure, composition, content are all similar to natural Calculus Bovis; pharmacodynamics, toxicologic study result prove safety; clinical efficacy is consistent with natural Calculus Bovis; and being higher than natural Calculus Bovis for some sick curative effect of planting, is the ideal substitute of natural Calculus Bovis.The quality standard of In vitro cultured Calculus Bovis is by " Chinese pharmacopoeia version in 2005 is recorded.
State Food and Drug Administration successively holds expert discussion on Wuhan, Beijing and other places, and whether alternative natural Calculus Bovis has carried out discussing again and again with Calculus Bovis cultivating to In vitro cultured Calculus Bovis.Detection to the multiple one-tenth such as content of bilirubin of In vitro cultured Calculus Bovis shows; In vitro cultured Calculus Bovis can substitute natural Calculus Bovis fully; State Food and Drug Administration is according to expert's conclusion, and decision can use 41 kinds of emergency and severe disease medications such as cow-bezoar bolus for resurrections In vitro cultured Calculus Bovis, Calculus Bovis cultivating to substitute.To solve this problem of Calculus Bovis insufficient raw material.The cultivation success of In vitro cultured Calculus Bovis will make more common people can benefit from the medicinal efficacy of Calculus Bovis.
On January 31st, 2004, State Food and Drug Administration sends " about the notice of Calculus Bovis and succedaneum use problem thereof ": for the new drug that contains Calculus Bovis of clinical anxious severe disease disease medicine variety that contains Calculus Bovis in the national drug standards prescription and the approval of national drug supervisory and management department, Calculus Bovis in the prescription can be substituted uses that feed intake of Calculus Bovis equivalent with Calculus Bovis cultivating, In vitro cultured Calculus Bovis, but it is alternative not to be able to the artificial Calculus Bovis; Other kinds that contain Calculus Bovis can substitute the use that feeds intake of Calculus Bovis equivalent with Calculus Bovis cultivating, In vitro cultured Calculus Bovis or artificial Calculus Bovis with the Calculus Bovis in the prescription.The scope of application to the artificial Calculus Bovis of this document limits, and can be equal to use with natural Calculus Bovis to In vitro cultured Calculus Bovis, also is the affirming of quality, drug effect, clinical efficacy to In vitro cultured Calculus Bovis.
Contain Realgar among the former side, be mode with powder add granulate again in the extractum exsiccant, a lot of enterprises are in the process of making, mostly baking temperature is at 85～105 ℃, and guarantee that for up to 2 hours ability the extract granule drying reaches the requirement of granule to moisture, still, when the extract granule that contains Realgar and Rhubarb 85～105 ℃ of bakings 2 hours, cause Realgar arsenic bloom in the granule, cause the toxicity of preparation to increase.The present invention adopts drying under reduced pressure (temperature: 60 ℃) in preparation technology, not only can dry granule, can also reduce the Realgar arsenic bloom, and guarantee the content of nontoxic composition orpiment.
Discover through us: the Radix Et Rhizoma Rhei that contains among the former side, be mode with powder add granulate again in the extractum exsiccant, the dissociated anthraquinone derivant is the Main Ingredients and Appearance that Radix Et Rhizoma Rhei has discharge function, dry in the granule of extractum preparation, temperature surpasses 85～95 ℃, and surpass 1 hour drying time, and the content of dissociated anthraquinone derivant can reduce by 60%, use drying under reduced pressure of the present invention (temperature: 60 ℃), can avoid the minimizing of active ingredient.
Summary of the invention
Purpose of the present invention is to select In vitro cultured Calculus Bovis for use, uses suitable process technology scheme, is prepared into a kind of preparation with effects for removing toxic heat.
The present invention constitutes like this, and calculate according to composition by weight: it is made for 8～12 parts by 1～2 part of In vitro cultured Calculus Bovis, 8～12 parts of Realgars, 35～45 parts in Gypsum Fibrosum, 35～45 parts of Radix Et Rhizoma Rhei, 25～35 parts of Radix Scutellariaes, 15～25 parts of Radix Platycodoniss, 3～6 parts of Borneolum Syntheticums, Radix Glycyrrhizae.
Specifically, calculate according to composition by weight: it is made for 10 parts by 1 part of In vitro cultured Calculus Bovis, 10 parts of Realgars, 40 parts in Gypsum Fibrosum, 40 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Scutellariaes, 20 parts of Radix Platycodoniss, 5 parts of Borneolum Syntheticums, Radix Glycyrrhizae.
Described preparation is pill, capsule or tablet.
The preparation method of preparation of the present invention is:
The first step: Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Above-mentioned powder is standby.
Second step: decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.
The 3rd step: add Radix Et Rhizoma Rhei, Realgar powder in thick paste, make granule, drying under reduced pressure (baking temperature: 60 ℃) is cooled to room temperature, adds In vitro cultured Calculus Bovis, borneol powder again, and mixing is prepared into pill, tablet or capsule according to conventional method then.
Described pill is preparation like this: Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.In thick paste, add Radix Et Rhizoma Rhei, Realgar powder, make granule, drying under reduced pressure (baking temperature: 60 ℃); be cooled to room temperature, add In vitro cultured Calculus Bovis, borneol powder again, mixing; be ground into fine powder again, be prepared into pill according to the preparation method of water pill (or water-honeyed pill).
Described capsule is preparation like this: Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.Add Radix Et Rhizoma Rhei, Realgar powder in thick paste, make granule, drying under reduced pressure (baking temperature: 60 ℃) is cooled to room temperature, adds In vitro cultured Calculus Bovis, borneol powder again, mixing, and filled capsules is prepared from.
Described tablet is preparation like this: Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.Add Radix Et Rhizoma Rhei, Realgar powder in thick paste, make granule, drying under reduced pressure (baking temperature: 60 ℃) is cooled to room temperature, adds In vitro cultured Calculus Bovis, borneol powder again, and mixing adds lubricant, and tabletting is prepared from.
For showing therapeutic effect of the present invention, as follows with Chinese patent medicine of the present invention (tablet) treatment 350 routine all kinds of gingival swelling and pain, aphtha of the mouth and tongue, conjunctival congestion and swelling pain patient's clinical efficacy statistics.
One, case is selected
350 routine patients all pass through clinical definite, wherein male 180 examples, women 170 examples, age reckling 19 years old, the oldest person 69 years old.
Two, Therapeutic Method
To above patient, give Chinese patent medicine of the present invention and take, 2～3 times on the one, one time 3, eliminating cold for resuscitation water is taken.Per 3 days courses of treatment, take two courses of treatment continuously.
Three, criterion of therapeutical effect
Clinical cure: the positive sign of symptom and clinical examination all disappears, and recovers normal.Clinical produce effects: symptom disappears substantially, and other clinical examinations take an evident turn for the better, the basic recovery normally.Clinical effective: symptom makes moderate progress, and clinical examination take a favorable turn.Clinical invalid: symptom and clinical examination do not have obvious improvement.
Four, observation of curative effect effect
Clinical cure rate is 85.71%, and obvious effective rate is 92.86%, effective percentage: 97.14%, and the invalid rate of facing is: 2.86%.
The specific embodiment
The invention process example 1:
Get In vitro cultured Calculus Bovis 5g, Realgar 50g, Gypsum Fibrosum 200g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 150g, Radix Platycodonis 100g, Borneolum Syntheticum 25g, Radix Glycyrrhizae 50g.Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.Add Radix Et Rhizoma Rhei, Realgar powder in thick paste, make granule, drying under reduced pressure (baking temperature: 60 ℃) is cooled to room temperature; add In vitro cultured Calculus Bovis, borneol powder again, mixing adds lubricant; tabletting is prepared from 1000 (sheets) or 1500 (small pieces), or coating, promptly.
The invention process example 2:
Get In vitro cultured Calculus Bovis 5g, Realgar 50g, Gypsum Fibrosum 200g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 150g, Radix Platycodonis 100g, Borneolum Syntheticum 25g, Radix Glycyrrhizae 50g.Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.Add Radix Et Rhizoma Rhei, Realgar powder in thick paste, make granule, drying under reduced pressure (baking temperature: 60 ℃) is cooled to room temperature, adds In vitro cultured Calculus Bovis, borneol powder again, pulverizes, and makes water pill (or the general ball of water honey), polishing or coating, promptly.
The invention process example 3:
Get In vitro cultured Calculus Bovis 5g, Realgar 50g, Gypsum Fibrosum 200g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 150g, Radix Platycodonis 100g, Borneolum Syntheticum 25g, Radix Glycyrrhizae 50g.Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.Add Radix Et Rhizoma Rhei, Realgar powder in thick paste, make granule, drying under reduced pressure (baking temperature: 60 ℃) is cooled to room temperature, adds In vitro cultured Calculus Bovis, borneol powder again, adds minor amounts of lubricants, and filled capsules becomes 1000 or 1500.
Claims (5)
1. preparation with effects for removing toxic heat; it is characterized in that; calculate according to composition by weight, it is made by following component: 1～2 part of In vitro cultured Calculus Bovis, 8～12 parts of Realgars; 35～45 parts in Gypsum Fibrosum; 35～45 parts of Radix Et Rhizoma Rhei, 25～35 parts of Radix Scutellariaes, 15～25 parts of Radix Platycodoniss; 3～6 parts of Borneolum Syntheticums, 8～12 parts in Radix Glycyrrhizae.
2. according to the described preparation of claim 1, it is characterized in that calculate according to composition by weight, it is made by following component: 1 part of In vitro cultured Calculus Bovis, 10 parts of Realgars, 40 parts in Gypsum Fibrosum, 40 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Scutellariaes, 20 parts of Radix Platycodoniss, 5 parts of Borneolum Syntheticums, 10 parts in Radix Glycyrrhizae.
3. according to claim 1 or 2 described preparations, it is characterized in that: described preparation is pill, capsule or tablet.
4. according to the preparation method of right 1～3 each described preparation, it is characterized in that:
The first step: Realgar powder is broken into impalpable powder; Radix Et Rhizoma Rhei powder is broken into fine powder; In vitro cultured Calculus Bovis, Borneolum Syntheticum porphyrize and 120 orders that sieve.Above-mentioned powder is standby.
Second step: decoct with water secondary (each amount of water: be 15 times of medical material weight) after Radix Platycodonis, Radix Scutellariae, Gypsum Fibrosum and Radix Glycyrrhizae mixed, each 2 hours, collecting decoction filtered, and filtrate is condensed into thick paste.
The 3rd step: add Radix Et Rhizoma Rhei, Realgar powder in thick paste, make granule, drying under reduced pressure (baking temperature: 60 ℃) is cooled to room temperature, adds In vitro cultured Calculus Bovis, borneol powder again, and mixing is prepared into pill, tablet or capsule according to conventional method then.
5. the preparation that is prepared into according to claim 4 is characterized in that: the function with heat-clearing and toxic substances removing.The clinical symptoms that can be used for the treatment of burning hot interior Sheng, laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue, conjunctival congestion and swelling pain.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006803A (en) * | 2012-11-23 | 2013-04-03 | 郑州瑞龙制药股份有限公司 | Preparation method of detoxicating tablet of cow-bezoar |
| CN107982325A (en) * | 2016-10-26 | 2018-05-04 | 兰州大学 | A kind of Chinese medicine composition for treating inflammation and preparation method thereof |
| CN116370543A (en) * | 2023-04-20 | 2023-07-04 | 南京同仁堂药业有限责任公司 | Cattle yellow detoxification tablet and preparation method thereof |
-
2009
- 2009-08-11 CN CN2009101840157A patent/CN101991659A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006803A (en) * | 2012-11-23 | 2013-04-03 | 郑州瑞龙制药股份有限公司 | Preparation method of detoxicating tablet of cow-bezoar |
| CN103006803B (en) * | 2012-11-23 | 2014-06-18 | 郑州瑞龙制药股份有限公司 | Preparation method of detoxicating tablet of cow-bezoar |
| CN107982325A (en) * | 2016-10-26 | 2018-05-04 | 兰州大学 | A kind of Chinese medicine composition for treating inflammation and preparation method thereof |
| CN107982325B (en) * | 2016-10-26 | 2021-05-28 | 兰州大学 | A Chinese medicinal composition for treating inflammation, and its preparation method |
| CN116370543A (en) * | 2023-04-20 | 2023-07-04 | 南京同仁堂药业有限责任公司 | Cattle yellow detoxification tablet and preparation method thereof |
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Open date: 20110330 |