CN116370543A - Cattle yellow detoxification tablet and preparation method thereof - Google Patents
Cattle yellow detoxification tablet and preparation method thereof Download PDFInfo
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- CN116370543A CN116370543A CN202310427458.4A CN202310427458A CN116370543A CN 116370543 A CN116370543 A CN 116370543A CN 202310427458 A CN202310427458 A CN 202310427458A CN 116370543 A CN116370543 A CN 116370543A
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- bezoar
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- 238000002360 preparation method Methods 0.000 title claims abstract description 72
- 238000001784 detoxification Methods 0.000 title claims abstract description 50
- 241000283690 Bos taurus Species 0.000 title claims abstract description 21
- 206010004542 Bezoar Diseases 0.000 claims abstract description 54
- 239000000284 extract Substances 0.000 claims abstract description 25
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 24
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 24
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940116229 borneol Drugs 0.000 claims abstract description 20
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 20
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 20
- 240000000691 Houttuynia cordata Species 0.000 claims abstract description 18
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 15
- 240000004980 Rheum officinale Species 0.000 claims abstract description 14
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 14
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 12
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 12
- 239000010440 gypsum Substances 0.000 claims abstract description 12
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 11
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 11
- 235000006533 astragalus Nutrition 0.000 claims abstract description 11
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 11
- 235000011477 liquorice Nutrition 0.000 claims abstract description 11
- 241001061264 Astragalus Species 0.000 claims abstract description 10
- 210000004233 talus Anatomy 0.000 claims abstract description 10
- 235000013717 Houttuynia Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 240000001949 Taraxacum officinale Species 0.000 claims abstract 3
- 239000000843 powder Substances 0.000 claims description 64
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 53
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 34
- 238000003756 stirring Methods 0.000 claims description 33
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 30
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 22
- 239000011248 coating agent Substances 0.000 claims description 21
- 238000000576 coating method Methods 0.000 claims description 21
- 238000001035 drying Methods 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000000706 filtrate Substances 0.000 claims description 16
- 239000005639 Lauric acid Substances 0.000 claims description 15
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 14
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 14
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- 239000007788 liquid Substances 0.000 claims description 9
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- 238000005507 spraying Methods 0.000 claims description 9
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- 235000015092 herbal tea Nutrition 0.000 claims description 8
- 235000013616 tea Nutrition 0.000 claims description 7
- 239000004408 titanium dioxide Substances 0.000 claims description 7
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- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 2
- 244000269722 Thea sinensis Species 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 23
- 235000013719 Houttuynia cordata Nutrition 0.000 abstract description 9
- 230000003387 muscular Effects 0.000 abstract description 4
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- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 6
- 229930003944 flavone Natural products 0.000 description 6
- 150000002212 flavone derivatives Chemical class 0.000 description 6
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 6
- 208000000112 Myalgia Diseases 0.000 description 5
- 208000015001 muscle soreness Diseases 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 241000045403 Astragalus propinquus Species 0.000 description 1
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- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
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- 238000001816 cooling Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- FCZCIXQGZOUIDN-UHFFFAOYSA-N ethyl 2-diethoxyphosphinothioyloxyacetate Chemical compound CCOC(=O)COP(=S)(OCC)OCC FCZCIXQGZOUIDN-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
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- 239000007858 starting material Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Classifications
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Abstract
The present application relates to the technical field of pharmaceutical formulations. In particular to a cattle yellow detoxification tablet and a preparation method thereof. The raw materials of the cattle yellow detoxification tablet comprise the following components in parts by weight: 3-8 parts of bezoar, 180-220 parts of gypsum, 130-170 parts of astragalus, 20-30 parts of borneol, 40-60 parts of realgar, 180-220 parts of rheum officinale, 80-120 parts of platycodon grandiflorum, 40-60 parts of liquorice, 20-40 parts of dandelion and 5-15 parts of cordate houttuynia extract. The dandelion and houttuynia cordata extracts are utilized in the application, so that the curative effect of the bezoar detoxification tablet on clearing heat and detoxifying can be improved, and the symptoms of muscular soreness of patients with excessive internal heat can be treated.
Description
Technical Field
The application relates to the technical field of pharmaceutical preparations, in particular to a cattle yellow detoxification tablet and a preparation method thereof.
Background
The bezoar detoxicating tablet is prepared from eight traditional Chinese medicines of rhubarb, baical skullcap root, platycodon root, liquoric root, gypsum, artificial bezoar, borneol and realgar, has the efficacy of clearing heat and detoxicating, and is used for treating excessive internal heat, sore throat, gum swelling and pain, sores on the mouth and tongue and conjunctival congestion and swelling and pain. However, usually, the patients with excessive internal heat often have symptoms of muscular soreness, and the bezoar detoxification tablet has a single treatment effect and cannot treat other symptoms caused by excessive internal heat.
Disclosure of Invention
In order to diversify the treatment effect of the bezoar detoxification tablet, the application provides a bezoar detoxification tablet and a preparation method thereof.
In a first aspect, the present application provides a ox yellow detoxification tablet, which adopts the following technical scheme:
the raw materials of the cattle yellow detoxification tablet comprise the following components in parts by weight: 3-8 parts of bezoar, 180-220 parts of gypsum, 130-170 parts of astragalus, 20-30 parts of borneol, 40-60 parts of realgar, 180-220 parts of rheum officinale, 80-120 parts of platycodon grandiflorum, 40-60 parts of liquorice, 20-40 parts of dandelion and 5-15 parts of cordate houttuynia extract.
By adopting the technical scheme, the dandelion and houttuynia cordata extracts have good heat-clearing and detoxifying effects, and the efficacy of the bezoar detoxifying tablet can be further improved by adding the extracts into the bezoar detoxifying tablet; in addition, the extracts of dandelion and houttuynia cordata are added into the bezoar detoxification tablet, and the applicant has unexpectedly found that the bezoar detoxification tablet also has the effect of treating muscle soreness, so that the curative effect of the bezoar detoxification tablet is diversified.
In a specific embodiment, the preparation method of the houttuynia cordata extract comprises the following steps:
pulverizing herba Houttuyniae to obtain herba Houttuyniae powder, adding polyethoxy lauric acid and herbal tea alcohol into herba Houttuyniae powder, stirring, mixing, adding ethanol solution, stirring to obtain mixed solution, extracting in water bath, layering, concentrating supernatant, and drying to obtain herba Houttuyniae extract.
By adopting the technical scheme, the separation of active ingredients in the houttuynia cordata can be promoted by utilizing the polyethoxy lauric acid cool tea alcohol, so that the curative effect of the houttuynia cordata extract is improved.
In a specific embodiment, the mixed liquor water bath extraction temperature is 60-80 ℃ and the extraction time is 50-60min.
In a specific embodiment, the mass concentration of the polyethoxy lauric acid herbal tea alcohol in the mixed solution is 0.5-1.5g/L.
By adopting the technical scheme, the time and the temperature of water bath extraction and the consumption of the polyethoxy lauric acid cool tea alcohol are further limited, so that the extraction effect of the cordate houttuynia is improved.
In a second aspect, the preparation method of the cattle yellow detoxification tablet provided by the application adopts the following technical scheme:
a preparation method of a cattle yellow detoxification tablet comprises the following steps:
grinding radix et rhizoma Rhei, realgar, calculus bovis, and Borneolum Syntheticum into fine powder; decocting Gypsum Fibrosum, radix astragali, radix Platycodi, glycyrrhrizae radix and herba Taraxaci in water twice, filtering, mixing the filtrates, concentrating the filtrate to obtain fluid extract, adding radix et rhizoma Rhei powder, realgar powder and herba Houttuyniae extract, stirring, granulating, drying, adding calculus bovis powder and Borneolum Syntheticum powder, stirring, and tabletting to obtain tablet; spraying the coating solution on the tablet, and drying to obtain the detoxicating tablet.
By adopting the technical scheme, rheum officinale, realgar, bezoar and borneol are firstly ground into powder, then gypsum, astragalus, platycodon grandiflorum, liquorice and dandelion are decocted, the liquid is concentrated to obtain clear paste, rheum officinale powder and realgar powder are firstly added, granulating is carried out, bezoar powder and borneol powder are then added, tabletting is carried out, a tablet is obtained, and finally, the coating liquid is sprayed on the tablet, and the tablet is dried, so that the bezoar detoxification tablet with good curative effect is obtained.
In a specific embodiment, the preparation method of the coating liquid comprises the following steps:
sequentially adding acrylic resin and hypromellose into medicinal ethanol, stirring, adding titanium dioxide and magnesium stearate after the hypromellose is dissolved, and stirring and mixing to obtain coating solution.
In a specific embodiment, the weight ratio of the magnesium stearate, the titanium pigment, the hypromellose, the acrylic resin, and the ethanol is 1: (8-10): (10-20): (8-10): (80-120).
In a specific embodiment, gypsum Fibrosum, radix astragali, radix Platycodi, glycyrrhrizae radix, and herba Taraxaci are decocted with water twice for 1.5-2.5 hr.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the dandelion and houttuynia cordata extracts have good heat-clearing and detoxifying effects, and the efficacy of the bezoar detoxifying tablet can be further improved by adding the extracts into the bezoar detoxifying tablet; in addition, the dandelion and houttuynia cordata extracts are added into the bezoar detoxification tablet, so that the applicant has unexpectedly found that the bezoar detoxification tablet also has the effect of treating muscle soreness, and therefore the curative effect of the bezoar detoxification tablet is diversified; 2. in the application, the herba houttuyniae is extracted by using the polyethoxy lauric acid herbal tea alcohol, so that the separation of active ingredients in the herba houttuyniae can be promoted, and the curative effect of the herba houttuyniae extract is improved;
3. grinding rheum officinale, realgar, bezoar and borneol, decocting gypsum, astragalus mongholicus, platycodon grandiflorum, liquorice and dandelion, concentrating the decoction to obtain clear paste, adding rheum officinale powder, realgar powder and houttuynia cordata extract, granulating, adding bezoar powder and borneol powder, tabletting to obtain a tablet, finally spraying coating liquid on the tablet, and drying to obtain the bezoar detoxication tablet with good curative effect.
Detailed Description
The present application is described in further detail below with reference to examples.
All the starting materials in the examples are commercially available. Wherein the titanium dioxide is medicinal titanium dioxide and the acrylic resin is acrylic resin IV.
Preparation example
Preparation example 1
Preparation example 1 provides a preparation method of a houttuynia cordata extract, which comprises the following steps:
pulverizing herba Houttuyniae to obtain herba Houttuyniae powder, adding polyethoxy lauric acid and herbal tea alcohol into herba Houttuyniae powder, stirring, mixing, adding 50% ethanol solution, stirring to obtain mixed solution, extracting in water bath at 60deg.C for 60min, layering, concentrating supernatant, and drying to obtain herba Houttuyniae extract; wherein the mass concentration of the polyethoxy lauric acid cool tea alcohol in the mixed solution is 0.5g/L; the weight ratio of the cordate houttuynia powder to the ethanol solution is 1:10.
preparation example 2
Preparation example 2 differs from preparation example 1 in that herba Houttuyniae is crushed to obtain herba Houttuyniae powder, polyethoxy lauric acid and tea alcohol are added into the herba Houttuyniae powder, stirring and mixing uniformly, 50% ethanol solution is added into the herba Houttuyniae powder, stirring uniformly to obtain mixed solution, water bath extraction is carried out at 70 ℃ for 55min, layering is carried out, and supernatant is concentrated and dried to obtain herba Houttuyniae extract; the remaining steps are identical to those of preparation 1.
Preparation example 3
Preparation example 3 differs from preparation example 1 in that herba Houttuyniae is crushed to obtain herba Houttuyniae powder, polyethoxy lauric acid and tea alcohol are added into the herba Houttuyniae powder, stirring and mixing uniformly, then 50% ethanol solution is added, stirring uniformly to obtain mixed solution, water bath extraction is carried out at 80 ℃ for 50min, layering is carried out, and supernatant is concentrated and dried to obtain herba Houttuyniae extract; the remaining steps are identical to those of preparation 1.
Preparation example 4
Preparation example 4 differs from preparation example 2 in that the mass concentration of the polyethoxy lauric acid herbal tea alcohol in the mixed solution is 1g/L; the remaining steps are identical to those of preparation 2.
Preparation example 5
Preparation example 5 differs from preparation example 2 in that the mass concentration of the polyethoxy lauric acid herbal tea alcohol in the mixed solution is 1.5g/L; the remaining steps are identical to those of preparation 2.
Preparation example 6
Preparation example 6 provides a preparation method of a houttuynia cordata extract, which comprises the following steps:
pulverizing herba Houttuyniae to obtain herba Houttuyniae powder, adding 50% ethanol solution into herba Houttuyniae powder, stirring to obtain mixed solution, extracting in water bath at 60deg.C for 60min, layering, concentrating supernatant, and drying to obtain herba Houttuyniae extract; wherein the weight ratio of the cordate houttuynia powder to the ethanol solution is 1:10.
preparation example 7
Preparation example 7 provides a preparation method of the coating liquid, which comprises the following steps:
sequentially adding acrylic resin and hypromellose into medicinal ethanol, stirring uniformly, adding titanium dioxide and magnesium stearate after the hypromellose is dissolved, and stirring uniformly to obtain coating liquid; wherein the weight ratio of magnesium stearate, titanium dioxide, hypromellose, acrylic resin and ethanol is 1:7:5:7:60.
preparation example 8
Preparation example 8 differs from preparation example 7 in that the weight ratio of magnesium stearate, titanium pigment, hypromellose, acrylic resin, and ethanol is 1:8:10:8:80; the remaining steps are identical to those of preparation 7.
Preparation example 9
Preparation example 9 differs from preparation example 7 in that the weight ratio of magnesium stearate, titanium pigment, hypromellose, acrylic resin, and ethanol is 1:9:15:9:100; the remaining steps are identical to those of preparation 7.
Preparation example 10
Preparation example 10 differs from preparation example 7 in that the weight ratio of magnesium stearate, titanium pigment, hypromellose, acrylic resin, and ethanol is 1:10:20:10:120; the remaining steps are identical to those of preparation 7.
PREPARATION EXAMPLE 11
Preparation 11 differs from preparation 7 in that the weight ratio of magnesium stearate, titanium pigment, hypromellose, acrylic resin, and ethanol is 1:11:25:11:140; the remaining steps are identical to those of preparation 7.
Examples
Example 1
Example 1 provides a preparation method of a cattle yellow detoxification tablet, comprising the following steps:
grinding 180g of rheum officinale, 40g of realgar, 3g of bezoar and 20g of borneol into fine powder; decocting 180g of gypsum, 130g of astragalus, 80g of platycodon grandiflorum, 40g of liquorice and 20g of dandelion with water twice for 2 hours each time, filtering, combining the two filtrates, concentrating the filtrate into clear paste, adding rhubarb powder, realgar powder and 5kg of cordate houttuynia extract in preparation example 1, uniformly stirring, granulating, drying, adding bezoar powder and borneol powder, uniformly stirring, and tabletting to obtain plain tablets; spraying the coating solution in preparation example 7 on plain tablet, and drying to obtain detoxicating tablet.
Examples 2 to 6
Examples 2-6 differ from example 1 in the choice of houttuynia cordata extract, as detailed in Table 1.
TABLE 1 selection of houttuynia cordata extract
Examples 7 to 10
Examples 7-10 differ from example 4 in the choice of coating solution, as detailed in Table 2.
Table 2 selection of coating solutions
| Sample of | Coating liquid is selected |
| Example 4 | Preparation example 7 |
| Example 7 | Preparation example 8 |
| Example 8 | Preparation example 9 |
| Example 9 | Preparation example 10 |
| Example 10 | PREPARATION EXAMPLE 11 |
Example 11
Example 11 provides a method for preparing a cattle yellow detoxification tablet, comprising the following steps:
grinding 200g of rheum officinale, 50g of realgar, 5g of bezoar and 25g of borneol into fine powder; decocting 200g of gypsum, 150g of astragalus, 100g of platycodon grandiflorum, 50g of liquorice and 30g of dandelion with water for 2 hours each time, filtering, combining the two filtrates, concentrating the filtrate into clear paste, adding rhubarb powder, realgar powder and 10kg of houttuynia cordata extract in preparation example 4, uniformly stirring, granulating, drying, adding bezoar powder and borneol powder, uniformly stirring, and tabletting to obtain plain tablets; spraying the coating solution in preparation example 9 on plain tablet, and drying to obtain detoxicating tablet.
Example 12
Example 12 provides a method for preparing a cattle yellow detoxification tablet, comprising the following steps:
grinding 220g of rheum officinale, 60g of realgar, 8g of bezoar and 30g of borneol into fine powder; decocting 220g of gypsum, 170g of astragalus, 120g of platycodon grandiflorum, 60g of liquorice and 40g of dandelion with water twice for 2 hours each time, filtering, combining the two filtrates, concentrating the filtrate into clear paste, adding rhubarb powder, realgar powder and 15kg of cordate houttuynia extract in preparation example 4, uniformly stirring, granulating, drying, adding bezoar powder and borneol powder, uniformly stirring, and tabletting to obtain plain tablets; spraying the coating solution in preparation example 9 on plain tablet, and drying to obtain detoxicating tablet.
Comparative example
Comparative example 1
Comparative example 1 provides a preparation method of a cattle yellow detoxification tablet, comprising the following steps:
grinding 185g of rheum officinale, 40g of realgar, 3g of bezoar and 20g of borneol into fine powder; decocting 190g of gypsum, 135g of astragalus, 85g of platycodon grandiflorum and 40g of liquorice with water twice for 2 hours each time, filtering, combining the two filtrates, concentrating the filtrate into clear paste, adding rhubarb powder and realgar powder, uniformly stirring, granulating, drying, adding bezoar powder and borneol powder, uniformly stirring, and tabletting to obtain a plain tablet; spraying the coating solution in preparation example 7 on plain tablet, and drying to obtain detoxicating tablet.
Comparative example 2
Comparative example 2 provides a preparation method of a cattle yellow detoxification tablet, comprising the following steps:
grinding 185g of rheum officinale, 40g of realgar, 3g of bezoar and 20g of borneol into fine powder; decocting 180g of gypsum, 130g of astragalus, 80g of platycodon grandiflorum, 40g of liquorice and 20g of dandelion with water twice for 2 hours each time, filtering, combining the two filtrates, concentrating the filtrate into clear paste, adding rheum officinale powder and realgar powder, uniformly stirring, granulating, drying, adding calculus bovis powder and borneol powder, uniformly stirring, and tabletting to obtain a plain tablet; spraying the coating solution in preparation example 7 on plain tablet, and drying to obtain detoxicating tablet.
Comparative example 3
Comparative example 3 provides a preparation method of a cattle yellow detoxification tablet, comprising the following steps: grinding 185g of rheum officinale, 40g of realgar, 3g of bezoar and 20g of borneol into fine powder; decocting 185g of gypsum, 135g of astragalus, 85g of platycodon grandiflorum and 40g of liquorice with water twice for 2 hours each time, filtering, combining the two filtrates, concentrating the filtrate into clear paste, adding rhubarb powder, realgar powder and 5kg of cordate houttuynia extract in preparation example 1, uniformly stirring, granulating, drying, adding bezoar powder and borneol powder, uniformly stirring, and tabletting to obtain a plain tablet; spraying the coating solution in preparation example 7 on plain tablet, and drying to obtain detoxicating tablet.
Performance test
(1) The muscle soreness treatment effect: 40 patients with internal heat and muscular soreness are selected, the ages are selected from 20-65 years, every ten people is one group, the patients are divided into four groups, the bezoar detoxification tablets in the example 1 and the comparative examples 1-3 are respectively detected, 3 times a day and 3 tablets at a time are taken for three days, and the number of people with improved muscular soreness symptoms of the patients is obtained.
(2) Dissolution rate: the dissolution rate of flavone in the bezoar detoxification tablet is measured by detecting the bezoar detoxification tablet in each embodiment, and the higher the dissolution rate is, the better the curative effect of the bezoar detoxification tablet is.
(3) Moisture resistance: the detoxicating tablet of calculus bovis in each example was placed in an open clean container, and left in a constant temperature and humidity environment, and the surface of the detoxicating tablet was observed after two weeks.
TABLE 3 detection results of detoxicating tablet of bezoar
By combining the embodiment 1 with the comparative examples 1-3, the dissolution rate of the flavone in the bezoar detoxification tablet in the embodiment 1 is the highest, and the bezoar detoxification tablet has a certain treatment effect on muscle soreness, and the addition of the dandelion and the houttuynia cordata extracts simultaneously in the preparation of the bezoar detoxification tablet can not only improve the drug effect of the bezoar detoxification tablet, but also ensure that the bezoar detoxification tablet has the treatment effect on muscle soreness.
In combination with examples 1 to 3, the dissolution rate of flavone in the detoxicating tablet of example 2 is highest, and it can be seen that the extraction condition of herba Houttuyniae in example 2 is best when herba Houttuyniae is extracted.
By combining the embodiment 1 and the embodiment 6, the dissolution rate of the flavone in the bezoar detoxification tablet in the embodiment 1 is higher, and the addition of the polyethoxy lauric acid herbal tea alcohol can improve the extraction effect of the houttuynia cordata when the houttuynia cordata is extracted, so that the dissolution rate of the bezoar detoxification tablet is improved.
In combination of examples 2, 4 and 5, the dissolution rate of flavone in the detoxicating tablet of example 4 is highest, and it can be seen that increasing the consumption of polyethoxy lauric acid and cooling tea alcohol when herba Houttuyniae is extracted, the extraction effect of herba Houttuyniae tends to increase and decrease.
In combination with examples 4 and examples 7 to 10, the bezoar detoxification tablet in examples 7 to 9 has better anti-wetting performance, and the preferable proportion of magnesium stearate, titanium pigment, hypromellose, acrylic resin and ethanol is 1: (8-10): (10-20): (8-10): (80-120), the coating liquid has good coating effect, so that the anti-wetting performance of the bezoar detoxicated tablet is improved.
By combining the embodiment 8, the embodiment 11 and the embodiment 12, the dissolution rate of the flavone in the bezoar detoxification tablet in the embodiment 11 is highest, and the trend that the curative effect of the bezoar detoxification tablet is improved and then reduced after the use amount of raw materials is increased when the bezoar detoxification tablet is prepared is seen.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (8)
1. A cattle yellow detoxification tablet, which is characterized in that: the raw materials of the detoxification tablet comprise the following components in parts by weight: 3-8 parts of bezoar, 180-220 parts of gypsum, 130-170 parts of astragalus, 20-30 parts of borneol, 40-60 parts of realgar, 180-220 parts of rheum officinale, 80-120 parts of platycodon grandiflorum, 40-60 parts of liquorice, 20-40 parts of dandelion and 5-15 parts of cordate houttuynia extract.
2. The cattle yellow detoxification tablet according to claim 1, wherein: the preparation method of the houttuynia cordata extract comprises the following steps:
pulverizing herba Houttuyniae to obtain herba Houttuyniae powder, adding polyethoxy lauric acid and herbal tea alcohol into herba Houttuyniae powder, stirring, mixing, adding ethanol solution, stirring to obtain mixed solution, extracting in water bath, layering, concentrating supernatant, and drying to obtain herba Houttuyniae extract.
3. The cattle yellow detoxification tablet according to claim 2, wherein: the water bath extraction temperature of the mixed solution is 60-80 ℃ and the extraction time is 50-60min.
4. The cattle yellow detoxification tablet according to claim 2, wherein: the mass concentration of the polyethoxy lauric acid cool tea alcohol in the mixed solution is 0.5-1.5g/L.
5. A method for preparing the bezoar detoxification tablet according to any one of claims 1-4, wherein: the method comprises the following steps:
grinding radix et rhizoma Rhei, realgar, calculus bovis, and Borneolum Syntheticum into fine powder; decocting Gypsum Fibrosum, radix astragali, radix Platycodi, glycyrrhrizae radix and herba Taraxaci in water twice, filtering, mixing the filtrates, concentrating the filtrate to obtain fluid extract, adding radix et rhizoma Rhei powder, realgar powder and herba Houttuyniae extract, stirring, granulating, drying, adding calculus bovis powder and Borneolum Syntheticum powder, stirring, and tabletting to obtain tablet; spraying the coating solution on the tablet, and drying to obtain the detoxicating tablet.
6. The method for preparing the cattle yellow detoxification tablet according to claim 5, wherein the method comprises the following steps: the preparation method of the coating liquid comprises the following steps:
sequentially adding acrylic resin and hypromellose into medicinal ethanol, stirring, adding titanium dioxide and magnesium stearate after the hypromellose is dissolved, and stirring and mixing to obtain coating solution.
7. The method for preparing the cattle yellow detoxification tablet according to claim 6, wherein the method comprises the following steps: the weight ratio of the magnesium stearate to the titanium dioxide to the hydroxypropyl methylcellulose to the acrylic resin to the ethanol is 1: (8-10): (10-20): (8-10): (80-120).
8. The method for preparing the cattle yellow detoxification tablet according to claim 5, wherein the method comprises the following steps: decocting Gypsum Fibrosum, radix astragali, radix Platycodi, glycyrrhrizae radix and herba Taraxaci in water for 1.5-2.5 hr twice.
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