CN104013929A - Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof - Google Patents
Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and a preparation method thereof. The preparation method comprises the following steps: (1) respectively distilling rhizoma atractylodis, radix clematidis, turmeric, radix angelicae pubescentis and notopterygium root, and extracting volatile oil; (2) adding water into the decoction dregs of the rhizoma atractylodis and radix clematidis and red flower for decocting and extracting; (3) adding water into the decoction dregs of the turmeric, radix angelicae pubescentis and notopterygium root, golden cypress and Caulis Spatholobi for decocting and extracting; (4) extracting the decoction dregs by using ethanol; (5) adding the filtrates in the step (2) and the step (3) into the distilled aqueous solution in the step (1), and concentrating into extract for later use; (6) adding apiary and the fried frankincense into ethanol for extracting, and concentrating into thick paste; and (7) grinding nine raw material medicines such as Bungarus Parvus, long-noded pit viper, zaocys dhumnade, ground beeltle, fried myrrh, scorpio, centipede, earthworm and cassia twig, and screening for later use; merging the thick paste obtained in the steps (4), (5) and (6), performing dry mixing on the raw medicine powder in the step (7), wetting the extract, uniformly mixing, preparing granules, spraying the volatile oil, moistening and performing split charging. The method has the characteristic that the extraction rate of active ingredients is increased.
Description
The application is to be the divisional application that on 06 01st, 2012, application number are 201210177637.9, denomination of invention is " a kind of rheumatic pain killing medicine and preparation method for the treatment of rheumatic arthritis and rheumatoid arthritis " applying date.
technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of rheumatism, i.e. a kind of rheumatic pain killing medicine and preparation method for the treatment of rheumatic arthritis and rheumatoid arthritis.
Background technology
In the prior art, rheumatic arthritis, rheumatoid arthritis are modern medicine names of disease, are equivalent to the numbness disease of Chinese medicine.Arthromyodynia is lasted longer, outbreak repeatedly, and joint stiffness and deforming, pain is violent, unable to flex and stretch the extremities, or pain numbness.The cause of disease of primary disease is taking the weak insufficiency of vital energy and blood of plain body as endogenous cause of ill; The pathogen such as wind, cold, wet, heat is the inducement that causes primary disease, the prognosis of primary disease, and general multipole stupid twining, is easy to repeatedly show effect, and is difficult for eradicating, and part severe patient easily causes permanent disbility, and even dead.At present, domestic a lot of medical personnel utilizes Chinese medicine to cure the disease and receives certain effect.But all not ideal enough.Rheumatic pain killing capsule is the pure Chinese medicinal preparation (the standard WS-522-(Z-99 of National Drug Administration)-2002 that national official approval is produced), Tonghua Golden-Horse Pharmaceutical Industry Co., Ltd. produces, authentication code: the accurate word Z20020129 of traditional Chinese medicines, clinical efficacy is definite, has received more satisfied curative effect.Formula: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g.The preparation method of rheumatic pain killing capsule is: get Rhizoma Atractylodis, Rhizoma Curcumae Longae and add water moisteningly, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four tastes decoct with water three times, amount of water is followed successively by 10,8,8 times, time is followed successively by 2,1.5,1 hours, filter, merging filtrate, add the aqueous solution after the distillation of Rhizoma Atractylodis, Rhizoma Curcumae Longae, being concentrated into relative density is 1.30(60-70 DEG C) extractum, for subsequent use.13 tastes such as Bungarus Parvus, Agkistrodon, Zaocys, Nidus Vespae, Flos Carthami, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Olibanum (stir-fry) Radix Angelicae Pubescentis, Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi are pulverized, and sieve for subsequent use, get crude drug dried bean noodles mixed 30 minutes, add again above-mentioned standby stream extractum wet mixing 30 minutes, mix granulation, dry, granulate, sprays into volatile oil, moistening, subpackage, to obtain final product.But because this medicine is researched and developed early, the effective ingredient of part medical material must be to making full use of, and larger by dosing, therefore production technology needs improvements in addition.Active constituents in vine stem of Spatholobus suberectus in prescription is flavonoid and glycoside, taking ononin as representative, and these compositions is fat-soluble better, dissolubility in hot water is limited, and former technique extracting method is water extraction, greatly limit the extraction of effective ingredient, caused fat-soluble effective ingredient to have too many waste.One of the main component of Radix Clematidis, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii volatile oil, by former PROCESS FOR TREATMENT, falls total loss.And active ingredient in Cortex Phellodendri, Rhizoma Curcumae Longae, Rhizoma Et Radix Notopterygii not only has water-soluble components, also has a large amount of fat-soluble active ingredients.The main component of Nidus Vespae, Olibanum is water-soluble hardly, is soluble in hot ethanol.Extract and can ensure, under the prerequisite that effective ingredient does not run off, to remove the impurity such as invalid components with hot ethanol.Flos Carthami is difficult for dry and pulverizes, and main component runs off serious in dry run.Its main component glycoside, flavonoid (Carthamus yellow has antiinflammatory and anthydropic effect) good water solubility.Therefore answer water extraction.In original prescription, Flos Carthami, Radix Angelicae Pubescentis, Nidus Vespae, Olibanum production technology are used as medicine for pulverizing, and cause patient's dosing larger, and each 5, every 0.3g, every day three times.And extract processing under the prerequisite that ensures medicine effect, reduce dose, but do not lessen the curative effect.Based on the object of above-mentioned medical material rationally being utilized and further improved the clinical efficacy of rheumatic pain killing capsule, we are not changing on the basis of former technology preparation, drug dose and former main technique, carry out the optimization of technique, invented a kind of simple, Yi Hang, be adapted to the production technology of industrialized great production.
Summary of the invention
In order to address the above problem, that the object of the invention is to provide is a kind of simple, Yi Hang, be adapted to industrialized great production, the preparation method of the rheumatic pain killing medicine of the more optimal treatment rheumatic arthritis of technique, rheumatoid arthritis.
Technical solution of the present invention is: a kind of preparation method of rheumatic pain killing medicine for the treatment of rheumatic arthritis and rheumatoid arthritis, and its step is as follows:
(1) crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
(2) preparation method:
1. get Rhizoma Atractylodis, Radix Clematidis and add water moisteningly, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
2. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter merging filtrate;
3. the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii and Cortex Phellodendri, Caulis Spatholobi are decocted with water three times, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters merging filtrate;
4. the medicinal residues after 3. step being extracted add 3-15 doubly to measure 30-90% ethanol extraction 2-3 time, and each 1-2 hour, filters merging filtrate, reclaim ethanol to without alcohol taste, with 3-10 times of calorimetric water, temperature 40-100 DEG C, fully dissolves, filtered while hot, filtrate is concentrated into thick paste shape, for subsequent use;
5. by step, 2. the filtrate in 3. adds the aqueous solution after 1. step distills with step, and being concentrated into relative density is 1.30,60-70 DEG C, extractum, for subsequent use;
6. Nidus Vespae, Olibanum (stir-fry) add 3-10 doubly to measure ethanol (30-90%), and 30-60 DEG C, soak 2-3 times, each 1-24 hours, filter, merging filtrate, reclaims ethanol to without alcohol taste, is concentrated into thick paste shape, for subsequent use;
7. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi nine taste crude drug are pulverized, and sieve for subsequent use;
By step 4., 5., 6. gained thick paste merge; Get 7. mixed 30 minutes of crude drug dried bean noodles of step, then add above-mentioned steps 4., 5., 6. gained extractum wet mixing 30 minutes, mix, granulation, dry, granulate, sprays into 1. gained volatile oil of step, moistening, subpackage, to obtain final product.
Dose: taking capsule as example: each 3～4, every 0.3～0.4g, every day three times.
By pharmacy and pharmacodynamics comparison before and after the improvement to technique, result is as follows:
1, the comparison of the content of effective ingredient before and after process modification
The examination criteria of the berberine hydrochloride of setting up according to the quality standard of pharmacopeia and seminar detects 3 batches of new and old handicraft products, and result is as follows:
The content of effective ingredient before and after table 1 process modification
Can find out from experimental result, new technology effective ingredient content of berberine hydrochloride has improved 100% left and right than former technique, and new technology accounts for clear superiority.
Advantage of the present invention is: after 1. the effective ingredient in Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Rhizoma Curcumae Longae, medicinal residues fully being extracted, carry out preparation, increased the extraction of volatile oil in Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Radix Clematidis, improved the rate of transform of effective ingredient, make full use of medical material; According to the character of medicine effective ingredient, Flos Carthami, Radix Angelicae Pubescentis, Nidus Vespae, the former pulverizing medication of Olibanum are changed into extraction process, increase activity, remove invalid components and impurity.2. the extraction ratio of effective ingredient increases, and pharmacologically active significantly increases, and content of berberine hydrochloride has improved 100% than former technique.3. under the prerequisite that ensures Flos Carthami, Radix Angelicae Pubescentis, Nidus Vespae, Olibanum curative effect, extract processing, reduce dose, but do not lessen the curative effect.4. simple, the Yi Hang of this technique, more optimize, be adapted to industrialized great production.5. experiment shows, technique of the present invention can extract more effective ingredient and bring into play the therapeutical effect of medicine, can ensure better the clinical efficacy of medicine, for arthralgia pain (rheumatic arthritis, rheumatoid arthritis) simultaneous occurrence of cold and heat syndromes, disease is seen muscle arthralgia, swelling, joint motion is limited, morning deadlock, the treatment of local pyrexia etc., can meet clinical treatment needs better.
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.
detailed description of the invention
Embodiment 1
The preparation method of rheumatic pain killing capsule, its step is as follows:
1. crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
2. get Rhizoma Atractylodis, Radix Clematidis and add water moisteningly, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use.Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use.
3. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter merging filtrate.
4. by the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, decoct with water three times with Cortex Phellodendri, Caulis Spatholobi, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters merging filtrate.
5. medicinal residues add 3-15 doubly to measure 30-90% ethanol extraction 2-3 time, each 1-2 hour, filter, merging filtrate, reclaim ethanol to without alcohol taste, with 3-10 times of calorimetric water (as 40-100 DEG C all can) fully dissolve (can be heated to if desired boiling), filtered while hot, filtrate is concentrated into thick paste shape, for subsequent use.
6. by step, 3. the filtrate in 4. adds the aqueous solution after 2. step distills with step, and being concentrated into relative density is 1.30(60-70 DEG C) extractum, for subsequent use.
7. Nidus Vespae, Olibanum (stir-fry) add 3-10 times of calorimetric ethanol (30-60 DEG C) to soak 2-3 times, and each 1-24 hours, filter, merging filtrate, reclaims ethanol to without alcohol taste, is concentrated into thick paste shape, for subsequent use.
8. nine tastes such as Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi are pulverized, and sieve for subsequent use
9. by step 5., 6., 7. gained thick paste merges, get 8. mixed 30 minutes of crude drug dried bean noodles of step, then add above-mentioned extractum wet mixing 30 minutes, mix, granulation, dry, granulate, sprays into volatile oil, moistening, granulation, incapsulates, and makes 1000, to obtain final product
Dose: taking capsule as example: each 3～4, every 0.3～0.4g, every day three times.
Embodiment 2
The preparation method of rheumatic pain killing capsule, its step is as follows:
(1) crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
(2) preparation method:
1. get Rhizoma Atractylodis, Radix Clematidis and add water moisteningly, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
2. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter merging filtrate;
3. the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii and Cortex Phellodendri, Caulis Spatholobi are decocted with water three times, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters merging filtrate;
4. the medicinal residues after 3. step being extracted add 8 times of amount 85% ethanol extractions 2 times, and each 1.5 hours, filter, merging filtrate, reclaims ethanol to without alcohol taste, by 5 times of calorimetric water, 90 DEG C of temperature, fully dissolves, filtered while hot, filtrate is concentrated into thick paste shape, for subsequent use;
5. by step, 2. the filtrate in 3. adds the aqueous solution after 1. step distills with step, and being concentrated into relative density is 1.30,60 DEG C, extractum, for subsequent use;
6. Nidus Vespae, Olibanum (stir-fry) add 8 times of amount ethanol (90%), and 50 DEG C, soak 3 times, each 24 hours, filter, merging filtrate, reclaims ethanol to without alcohol taste, is concentrated into thick paste shape, for subsequent use;
7. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi nine taste crude drug are pulverized, and sieve for subsequent use;
By step 4., 5., 6. gained thick paste merges, get 7. mixed 30 minutes of crude drug dried bean noodles of step, then add above-mentioned steps 4., 5., 6. gained extractum wet mixing 30 minutes, mix, granulation, dry, granulate, spray into 1. gained volatile oil of step, moistening, granulation, incapsulates, make 1000, to obtain final product.
Claims (2)
1. a preparation method for the treatment of the rheumatic pain killing medicine of rheumatic arthritis and rheumatoid arthritis, its step is as follows:
(1) crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (parched) 18.8 g, Olibanum (parched) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
(2) preparation method:
1. get Rhizoma Atractylodis, Radix Clematidis and add water moisteningly, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
2. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter merging filtrate;
3. the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii and Cortex Phellodendri, Caulis Spatholobi are decocted with water three times, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters merging filtrate;
4. the medicinal residues after 3. step being extracted add 3-15 doubly to measure 30-90% ethanol extraction 2-3 time, and each 1-2 hour, filters merging filtrate, reclaim ethanol to without alcohol taste, with 3-10 times of calorimetric water, temperature 40-100 DEG C, fully dissolves, filtered while hot, filtrate is concentrated into thick paste shape, for subsequent use;
5. by step, 2. the filtrate in 3. adds the 1. aqueous solution after rectification of step with step, and being concentrated into relative density is 1.30,60-70 DEG C, extractum, for subsequent use;
6. Nidus Vespae, Olibanum (parched) add 3-10 doubly to measure 30-90% ethanol, and 30-60 DEG C, soak 2-3 times, each 1-24 hours, filter, merging filtrate, reclaims ethanol to without alcohol taste, is concentrated into thick paste shape, for subsequent use;
7. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (parched), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi nine taste crude drug are pulverized, and sieve for subsequent use;
By step 4., 5., 6. gained thick paste merge; Get 7. mixed 30 minutes of crude drug dried bean noodles of step, then add above-mentioned steps 4., 5., 6. gained extractum wet mixing 30 minutes, mix, granulation, dry, granulate, sprays into 1. gained volatile oil of step, moistening, subpackage, to obtain final product.
2. according to the preparation method of the rheumatic pain killing medicine for the treatment of rheumatic arthritis claimed in claim 1 and rheumatoid arthritis, its step is as follows:
(1) crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (parched) 18.8 g, Olibanum (parched) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
(2) preparation method:
1. get Rhizoma Atractylodis, Radix Clematidis and add water moisteningly, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
2. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter merging filtrate;
3. the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii and Cortex Phellodendri, Caulis Spatholobi are decocted with water three times, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters merging filtrate;
4. the medicinal residues after 3. step being extracted add 8 times of amount 85% ethanol extractions 2 times, and each 1.5 hours, filter, merging filtrate, reclaims ethanol to without alcohol taste, by 5 times of calorimetric water, 90 DEG C of temperature, fully dissolves, filtered while hot, filtrate is concentrated into thick paste shape, for subsequent use;
5. by step, 2. the filtrate in 3. adds the aqueous solution after 1. step distills with step, and being concentrated into relative density is 1.30,60 DEG C, extractum, for subsequent use;
6. Nidus Vespae, Olibanum (parched) add 8 times of amount 90% ethanol, and 50 DEG C, soak 3 times, each 24 hours, filter, merging filtrate, reclaims ethanol to without alcohol taste, is concentrated into thick paste shape, for subsequent use;
7. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (parched), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi nine taste crude drug are pulverized, and sieve for subsequent use;
By step 4., 5., 6. gained thick paste merges, get 7. mixed 30 minutes of crude drug dried bean noodles of step, then add above-mentioned steps 4., 5., 6. gained extractum wet mixing 30 minutes, mix, granulation, dry, granulate, spray into 1. gained volatile oil of step, moistening, granulation, incapsulates, make 1000, to obtain final product.
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| CN106822185A (en) * | 2017-04-05 | 2017-06-13 | 贵州健瑞安药业有限公司 | A kind of composition for treating rheumatoid and preparation method thereof |
| CN107375759A (en) * | 2017-09-05 | 2017-11-24 | 夏季 | A kind of medicine for treating rheumatic arthritis and preparation method thereof |
| CN109395015A (en) * | 2018-10-25 | 2019-03-01 | 通化金马药业集团股份有限公司 | Rheumatic pain killing Chinese medicine composition is preparing the purposes in anti-angiogenic drugs |
| CN114177239A (en) * | 2022-01-18 | 2022-03-15 | 周奕达 | Plaster and preparation method thereof |
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| CN1943758A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of rheumatism and its preparation method |
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| CN1943758A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of rheumatism and its preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922481A (en) * | 2015-03-13 | 2015-09-23 | 安庆市凯达生物科技发展有限责任公司 | External traditional Chinese medicine composition for treating neck-shoulder and lumbocrural pain and preparation process thereof |
| CN106822185A (en) * | 2017-04-05 | 2017-06-13 | 贵州健瑞安药业有限公司 | A kind of composition for treating rheumatoid and preparation method thereof |
| CN107375759A (en) * | 2017-09-05 | 2017-11-24 | 夏季 | A kind of medicine for treating rheumatic arthritis and preparation method thereof |
| CN109395015A (en) * | 2018-10-25 | 2019-03-01 | 通化金马药业集团股份有限公司 | Rheumatic pain killing Chinese medicine composition is preparing the purposes in anti-angiogenic drugs |
| CN114177239A (en) * | 2022-01-18 | 2022-03-15 | 周奕达 | Plaster and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104013929B (en) | 2015-06-17 |
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