CN104826080A - Traditional Chinese medicine preparation for treating angina pectoris - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating angina pectoris. The traditional Chinese medicine preparation has the advantages that salvia miltiorrhiza, frankincense, baked licorice, angelica sinensis, prepared rehmannia glutinosa, hemiphragma heterophyllum, shaddock peel and mucuna macrocarpa wallich are used as monarch drugs in the preparation, so that effects of promoting blood circulation, removing stasis, promoting coronary circulation, relieving pain and eliminating phlegm can be realized; platycladi seeds, fistular onion stalk, gynostemma pentaphyllum, ophiopogon latifolius, orange peel, cucumbers, common calanthe and Chinese mahonia leaves are used as ministerial drugs, so that effects of activating yang, dispelling turbidity, eliminating phlegm and removing stagnation can be realized; coix leaves, orange leaves, clove tree bark, radishes, star anise, ginkgo leaves, lilies and fresh ginger are used as adjuvant drugs, so that effects of activating yang by the aid of the pungent and warm natured drugs, relieving arthralgia and dispelling cold can be realized; ginseng leaves, shamrock peas, roasted astragalus, codonopsis pilosula, lindera aggregata, allium macrostemon, fructus choerospondiatis, aconitum carmichaelii and albizia julibrissin are used as messenger drugs, so that effects of supplementing qi, nourishing yin, promoting blood circulation to remove meridian obstruction, benefiting qi and strengthening yang can be realized; the various drugs are used together, so that treatment based on syndrome differentiation can be carried out on the principle of taking temporary solution under emergency conditions and taking radical measures under relaxed conditions; the traditional Chinese medicine preparation can be matched with scientific nursing, so that excellent effects can be realized, and the angina pectoris can be cured.

Description

One treats anginal Chinese medicine preparation

Technical field

The present invention relates to the field of Chinese medicines, specifically one treats anginal Chinese medicine preparation.

Background technology

Angor is coronary insufficiency, cardiac muscle sharply, caused by ischemia and anoxia be the clinical syndrome of main manifestations with ictal chest pain or chest discomfort.Feature is shirtfront paroxysmal, squeezing property pain, can with other symptoms, and pain is mainly positioned at breastbone rear portion, can be radiated to pareordia and left upper extremity, work or excitedly often to occur, and each outbreak continues 3 ~ 5 minutes, can a few days once, also can one day for several times.Primary disease is more common in male, most more than 40 years old, tired, excited, be satiated with food, catch cold, rainy weather, acute circulatory failure etc. are common inducement.

The doctor trained in Western medicine cause of disease: anginal direct pathogenic factor is deficiency myocardial blood supply.And deficiency myocardial blood supply mainly comes from coronary heart disease.Sometimes, the heart disease of other types or hypertension out of control also can cause angina pectoris.If fat constantly deposition, will form speckle in blood vessel.If speckle occurs in coronary artery, its constriction will be caused, reduce it further to the blood supply of cardiac muscle, just define coronary heart disease.The process that in coronary artery, the continuous deposition of fat forms speckle is gradually called coronary atherosclerosis.Some specklees are harder and stable, will cause constriction and the sclerosis of coronary artery itself.Other speckle is soft, easy cracked formation blood clotting.The accumulation of this speckle of coronary artery inwall can cause angina pectoris in following two kinds of modes: 1. fixed position coronarius tube chamber constriction, so cause through blood flow greatly reduce; 2. the some or all of blocked coronary arteries of the blood clotting formed.

Clinical manifestation: after showing as vexed pain, squeezing property pain or breastbone, bottleneck throat constriction more, some patient only has uncomfortable in chest, simultaneously can be divided into typicality angina pectoris and atypism angina pectoris:

1. classical angina symptom

Unexpected generation be positioned at the squeezing after sternal body epimere or stage casing, vexed swollen property or asphyxiating pain, also most of pareordia may be involved, can be radiated to inside before left shoulder, left upper extremity, reach the third finger and little finger of toe, occasionally can with dying sense, often force patient to stop action immediately, severe one is also perspired.Pain lasts 1 ~ 5 minute, rarely exceeds 15 minutes; Have a rest or buccal nitroglycerin, pain (rarely exceeded 5 minutes) and disappears in 1 ~ 2 minute.Be everlasting tired, excited (angry, anxious, be overexcited), catch cold, be satiated with food, smoking time occur, anemia, tachycardia or shock also can be brought out.

2. atypical angina pectoris symptom

Pain can be positioned at inferior segment sternotomy, left pareordia or epigastrium, is radiated to neck, lower jaw, left scapular region or right front breast, and pain can disappear or only have left front breast discomfort, stuffy sense very soon.

The traditional Chinese medical science is thought: the pathological products such as pained due to healthy energy virtual loss, expectorant is turbid, congestion, the stagnation of QI, cold coagulation hinder in heart arteries and veins, and causes heart arteries and veins contraction anxious, clinically ictally to feel oppressed with Danzhong or left chest, a kind of disease that pain is main manifestations.Painedly have another name called precordial pain with cold limbs, chest pain.Primary disease is mainly in the middle-aged and elderly people of more than 40 years old.Its risk factor is often cold, heavy meal, fatigue and excited.

Name of disease sees "Nei Jing" the earliest, and all on the books to the cause of disease of primary disease, general symptom." Ling Shu Miraculous Pivot or Divine Axis five pathogenic factors " section is pointed out: " evil in the heart, then sick pained ", again at " during Plain Questions visceral-qi method opinion " medium cloud: " heart patient; chest pain, discomfort and fullness in the hypochondrium, pain over the hypochondrium; bear pain between back of the body omoplate, pain in the medial sides of both arms ", and Chinese Zhang Zhongjing is summarized as pathogenesis " weak pulse at YANG and stringy pulse at YIN " in " Medical Treasures of the Golden Chamber ", about treatment, " obstruction of qi in the chest and cardialgia lose heart disease " section is said ibideming: " obstruction of qi in the chest and cardialgia, dyspnea and expectoration, the pain over the chest and back; lose heart; pulse at CUN KOU being deep and slow, GUAN being pulse faint, tense and rapid, Chinese juniper beach wormwood Chinese onion Baijiu Tang master it "; " unable to tie down due to obstruction of QI in the chest, chest pain radiating to the back person.GualouXiebaiBanxia Decoction master it ".Later age, doctor enriched the method for the treatment of of primary disease, bright Wang Kentang " Standards of Diagnosis and Treatment " SHIXIAO SAN, Qing Dynasty's Wang Qingren errors in Medicine Corrected decoction for removing blood stasis, and treatment primary disease all have received good curative effect.

Symptom: pained show as breastbone after or the ictal vexed pain in pareordia uncomfortable.The accidental slight chest oppressiveness of the lighter or dull pain, or unclean sense of discomfort, severe one pain is more violent, can be causalgia, angor, twinge, can take on that the back of the body is few cloudy along hands, meridian of Hand-JUE YIN follows row position and diffuses left, the persistent period is shorter, how with cardiopalmus, breathe hard, pale complexion, cold extremities due to sweating, have a rest, dispel inducement or take aromatic herbs activating YANG medicine after, pain can be alleviated.Sick position: sick position is at the heart, relevant with liver,spleen,kidney.Because the physiological activity of the heart relies the catharsis of liver to help it, kidney essense is moistened and is supported to hold back it, spleen biochemical, transfer with ascending the clear and descending the turbid, inspire heart-yang.

Characteristic of disease is deficiency in origin and excess in superficiality.Its deficiency in origin divides the void of gas, blood, yin, yang; Mark is real is that expectorant is turbid, the stagnation of QI, blood stasis, cold coagulation.The general course of disease of primary disease is long, easy recurrent exerbation, and in time, accurately dialectical, symptom generally can be under control and mitigation in treatment, controls wrong treatment easily develop and faint intentionally if lose, so that threat to life.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine composition, promoting blood circulation, removing blood stasis and relieving pain can be reached, eliminating phlegm relieving accumulation of pathogens of promoting blood circulation, supplementing QI and nourishing YIN tonifying YANG object.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, the cause of disease of going directly, and healing time is short, control instant effect.

One of the present invention treats anginal Chinese medicine preparation, is to be monarch drug blood circulation promoting and blood stasis dispelling with Radix Salviae Miltiorrhizae, Olibanum, Radix Glycyrrhizae Preparata, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba hemipharagmatis heterophylli, Pericarpium Citri grandis, Caulis seu Radix Schisandrae Henryi, coronary circulation-promoting pain-relieving, to eliminate the phlegm; Turbid, eliminating phlegm relieving accumulation of pathogens is let out for ministerial drug activates yang with Semen Platycladi, Bulbus Allii Fistulosi, Herba Gynostemmatis, Radix Ophiopogonis Dracaenoidis, Pericarpium Citri junoris, Fructus Cucumidis sativi, Herba seu Radix Calanthes, Folium Mahoniae; Be adjuvant drug activating YANG with pungent and warm drugs with Folium Coicis, Folium citri sinensis, Cortex Caryophylli, Radix Raphani, Fructus Anisi Stellati, Folium Ginkgo, Flos Lilii viriduli, Rhizoma Zingiberis Recens, open numbness cold expelling; With Folium Ginseng, Herba Parocheti Communis, Radix Astragali Preparata, Radix Codonopsis, the Radix Linderae, Bulbus Allii Macrostemonis, Fructus Choerospondiatis, Radix Aconiti Lateralis Preparata, Flos Albiziae for making medicine supplementing QI and nourishing YIN, promoting blood circulation to remove obstruction in the collateral, QI invigorating tonifying YANG; All medicines share symptomatic treatment in acute condition, and radical treatment in chronic case is principle determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, coordinate the nursing of science often can obtain good effect, thus cure angina pectoris.

For solving the problems of the technologies described above, the invention provides one and treating anginal Chinese medicine preparation, in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Radix Salviae Miltiorrhizae 10-20 part, Olibanum 10-20 part, Radix Glycyrrhizae Preparata 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Rehmanniae Preparata 10-20 part, Herba hemipharagmatis heterophylli 10-20 part, Pericarpium Citri grandis 10-20 part, Caulis seu Radix Schisandrae Henryi 10-20 part, Semen Platycladi 1-10 part, Bulbus Allii Fistulosi 1-10 part, Herba Gynostemmatis 1-10 part, Radix Ophiopogonis Dracaenoidis 1-10 part, Pericarpium Citri junoris 1-10 part, Fructus Cucumidis sativi 1-10 part, Herba seu Radix Calanthes 1-10 part, Folium Mahoniae 1-10 part, Folium Coicis 1-10 part, Folium citri sinensis 1-10 part, Cortex Caryophylli 1-10 part, Radix Raphani 1-10 part, Fructus Anisi Stellati 1-10 part, Folium Ginkgo 1-10 part, Flos Lilii viriduli 1-10 part, Rhizoma Zingiberis Recens 1-10 part, Folium Ginseng 1-10 part, Herba Parocheti Communis 1-10 part, Radix Astragali Preparata 1-10 part, Radix Codonopsis 1-10 part, Radix Linderae 1-10 part, Bulbus Allii Macrostemonis 1-10 part, Fructus Choerospondiatis 1-10 part, Radix Aconiti Lateralis Preparata 1-10 part, Flos Albiziae 1-10 part.

One treats anginal Chinese medicine preparation, and in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Radix Salviae Miltiorrhizae 12-18 part, Olibanum 12-18 part, Radix Glycyrrhizae Preparata 12-18 part, Radix Angelicae Sinensis 12-18 part, Radix Rehmanniae Preparata 12-18 part, Herba hemipharagmatis heterophylli 12-18 part, Pericarpium Citri grandis 12-18 part, Caulis seu Radix Schisandrae Henryi 12-18 part, Semen Platycladi 2-8 part, Bulbus Allii Fistulosi 2-8 part, Herba Gynostemmatis 2-8 part, Radix Ophiopogonis Dracaenoidis 2-8 part, Pericarpium Citri junoris 2-8 part, Fructus Cucumidis sativi 2-8 part, Herba seu Radix Calanthes 2-8 part, Folium Mahoniae 2-8 part, Folium Coicis 2-8 part, Folium citri sinensis 2-8 part, Cortex Caryophylli 2-8 part, Radix Raphani 2-8 part, Fructus Anisi Stellati 2-8 part, Folium Ginkgo 2-8 part, Flos Lilii viriduli 2-8 part, Rhizoma Zingiberis Recens 2-8 part, Folium Ginseng 2-8 part, Herba Parocheti Communis 2-8 part, Radix Astragali Preparata 2-8 part, Radix Codonopsis 2-8 part, Radix Linderae 2-8 part, Bulbus Allii Macrostemonis 2-8 part, Fructus Choerospondiatis 2-8 part, Radix Aconiti Lateralis Preparata 2-8 part, Flos Albiziae 2-8 part.

One treats anginal Chinese medicine preparation, and in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Radix Salviae Miltiorrhizae 15 parts, Olibanum 15 parts, Radix Glycyrrhizae Preparata 15 parts, Radix Angelicae Sinensis 15 parts, Radix Rehmanniae Preparata 15 parts, Herba hemipharagmatis heterophylli 15 parts, Pericarpium Citri grandis 15 parts, Caulis seu Radix Schisandrae Henryi 15 parts, Semen Platycladi 5 parts, Bulbus Allii Fistulosi 5 parts, Herba Gynostemmatis 5 parts, Radix Ophiopogonis Dracaenoidis 5 parts, Pericarpium Citri junoris 5 parts, Fructus Cucumidis sativi 5 parts, Herba seu Radix Calanthes 5 parts, Folium Mahoniae 5 parts, Folium Coicis 5 parts, Folium citri sinensis 5 parts, Cortex Caryophylli 5 parts, Radix Raphani 5 parts, Fructus Anisi Stellati 5 parts, Folium Ginkgo 5 parts, Flos Lilii viriduli 5 parts, 5 parts, Rhizoma Zingiberis Recens, Folium Ginseng 5 parts, Herba Parocheti Communis 5 parts, Radix Astragali Preparata 5 parts, Radix Codonopsis 5 parts, the Radix Linderae 5 parts, Bulbus Allii Macrostemonis 5 parts, Fructus Choerospondiatis 5 parts, Radix Aconiti Lateralis Preparata 5 parts, Flos Albiziae 5 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of anginal Chinese medicine preparation, and the dosage form of described Chinese medicine composition is that sweet preparation method of refining pill comprises:

A, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1

B, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of anginal Chinese medicine preparation, and the dosage form of described Chinese medicine composition is that the preparation method of capsule comprises:

A, by Radix Salviae Miltiorrhizae, 10 times amount ethanol put into by Radix Angelicae Sinensis and Radix Aconiti Lateralis Preparata, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, merged by 2 extracting solution and leave standstill;

B, surplus stock is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

C, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder mix homogeneously and incapsulate.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of anginal Chinese medicine preparation, and the dosage form of described Chinese medicine composition is that the preparation method of tablet comprises:

By Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, 10 times amount ethanol put into by Radix Aconiti Lateralis Preparata, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, merged by 2 extracting solution and leave standstill; 10 times of water gagings put into by the surplus stock got again in above-mentioned side, heating and refluxing extraction 3 times, each 30 minutes ~ 1 hour, merged by 3 extracting solution and leave standstill; Merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of anginal Chinese medicine preparation, and pharmaceutical dosage form can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, pin powder or slow releasing capsule.

Chinese medicine composition of the present invention meets Chinese medicine and pharmacy theory, compatibility with monarch principle prescription, there is promoting blood circulation, removing blood stasis and relieving pain, eliminating phlegm relieving accumulation of pathogens of promoting blood circulation, supplementing QI and nourishing YIN tonifying YANG effect, cure mainly angina pectoris, coronary heart disease.Processing technology of the present invention is easy, and toxic and side effects is little, and convenient drug administration, medicament is easy to manufacture, with low cost.

the present invention relates to raw material of Chinese medicine pharmacology and the property of medicine:

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] is bitter, is slightly cold.GUIXIN, Liver Channel.

[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, being slightly cold of " herbal classic " meaning, TAO Hong-Jing has doubted it by mistake, and Miao's secondary alcohol also doubts it, and stupid to a stone is transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Except wind, Xing stays heat, takes sharp people for a long time.TAO Hong-Jing: stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, pain numbness, main attacked by pestiferous factors; Control stomachache, gas is done sound ring and is shouted." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation, logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle.

Olibanum: regulating QI, invigorates blood circulation, and pain relieving chases after poison.Antibacterial, restrain, flatulence of dispelling, promote wound scab, promote cytoactive, profit digestion, diuresis, calmness, benefit body, sharp uterus, control wound.

Radix Glycyrrhizae Preparata:

[meridian distribution of property and flavor] sweet in the mouth, flat; GUIXIN, lung, spleen, stomach warp.

[function cures mainly] spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse, can separate Radix Aconiti Lateralis Preparata poison.

Radix Angelicae Sinensis:

[nature and flavor] are warm in nature, hide sweet, pungent.

[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Radix Rehmanniae Preparata:

[meridian distribution of property and flavor] is sweet, tepor; Return liver, kidney channel.

[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Herba hemipharagmatis heterophylli:

The herb that [subject source] is goatweed diversifolious hemiphragma herb or root.

[nature and flavor] taste is micro-sweet; Light; Warm in nature.1. " Zhiwu Mingshi Tukao ": " warm in nature, taste is micro-sweet." 2. " Guizhou medical herbs ": " property is put down, and taste is micro-sweet." 3. " Chinese herbal medicine is commonly used in Tibet ": " warm in nature, lightly seasoned.”

[return through] GUIXIN; Liver Channel.

[function with cure mainly] promoting blood flow to regulate menstruation, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness.For amenorrhea, menoxenia, pulmonary tuberculosis, tonsillitis, traumatic injury, lumbago due to pathogenic wind-dampness; QI invigorating pain relieving, blood stasis removing stops blooding, and control cough and spit blood, neurasthenia, amenorrhea is suffered from abdominal pain; Eczema is controlled in external, skin infection, stomatitis, scrofula, and skin ulcer swells noxious dampness, tetanus.

Pericarpium Citri grandis:

It is pungent, sweet, bitter, temperature.Return spleen, kidney, urinary bladder channel.Have reduce phlegm, help digestion, effect of the therapeutic method to keep the adverse QI flowing downwards, fast diaphragm.Be usually used in the stagnation of QI uncomfortable in chest, coldness and pain in the epigastrium, dyspepsia, cough with asthma, hernia.

Caulis seu Radix Schisandrae Henryi: pungent, temperature, nontoxic.Function cures mainly: nourish blood repercussive, regulating QI to expel dampness.Control consumptive disease wound to spit blood, podomere ache, heart peratodynia, beriberi flaccidity syndrome and arthralgia syndrome, menoxenia, traumatic injury.

Semen Platycladi:

[nature and flavor]: sweet, flat.GUIXIN, kidney, large intestine channel.

[function cures mainly]: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.

Bulbus Allii Fistulosi:

[return through] lung; Stomach warp

[effect] is delivered; Activate yang; Removing toxic substances; Parasite killing

Herba Gynostemmatis:

[nature and flavor]: bitter in the mouth; Micro-sweet; Cool in nature.

[effect]: replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.

Radix Ophiopogonis Dracaenoidis:

[nature and flavor] property is put down, sweet in the mouth.

[function cures mainly] centering is calmed the nerves, and relieving cough and resolving phlegm, controls cardiopalmus, rheumatic heart disease, pulmonary tuberculosis, chronic tracheitis, bronchitis.

Pericarpium Citri junoris:

Pericarpium Citri junoris acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian;

There is invigorating the spleen and regulating the stomach, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, effect of lowering the adverse-rising QI and eliminating phlegm;

Cure mainly stagnation of QI in spleen and stomach, gastral cavity abdomen covers with, nausea and vomiting, inappetence, cough with copious phlegm, and chest and diaphragm is full vexed, globus hystericus.

Fructus Cucumidis sativi:

Nature and flavor: sweet in the mouth; Cool in nature.

Gui Jing: return lung; Spleen; Stomach warp.

Function cures mainly: heat clearing away; Diuretic; Removing toxic substances.Main calentura is thirsty; Oliguria with reddish urine; Edema oliguria; Burn due to hot liquid or fire; Tinea versicolor; Non-skin ulcer.

Herba seu Radix Calanthes:

[nature and flavor] are warm in nature, and sweet in the mouth is pungent, nontoxic.

[function cures mainly] eliminating stagnation, removing toxic substances, invigorates blood circulation, relaxing muscles and tendons.Control scrofula, tonsillitis, hemorrhoid, traumatic injury.

Folium Mahoniae:

[meridian distribution of property and flavor]: bitter, cold; " decoction pieces is newly joined ": " bitter, cool." enter liver, stomach, large intestine three warp; " book on Chinese herbal medicine is new again ": " enter lung meridian.”

[effect]: heat clearing away tonify deficiency, relieving cough and resolving phlegm.

[curing mainly]: control pulmonary tuberculosis hemoptysis, osteopyrexia and fever, dizziness and tinnitus, waist soreness, vexed, conjunctival congestion.

Folium Ginseng:

[meridian distribution of property and flavor] is bitter, sweet, cold.Attach to the lung and stomach meridians.

[function cures mainly] QI invigorating, lung benefiting, drives away summer heat, and promotes the production of body fluid.For qi-asthenia cough, summer-heat is irritated, and Tianjin wound is thirsty, and the head is unclear, and extremity are tired weary.

Herba Parocheti Communis:

[nature and flavor] are sweet; Temperature

[return through] kidney channel.

[function cures mainly] impotence due to deficiency of the kidney.Master suffers from a deficiency of the kidney, sexual impotence.

Radix Astragali Preparata:

[meridian distribution of property and flavor] is sweet, temperature.Return lung, spleen channel.

The invigorating middle warmer of [function cures mainly] QI invigorating.Weak for the deficiency of vital energy, anorexia and loose stool.

Radix Codonopsis:

[meridian distribution of property and flavor] sweet in the mouth, micro-acid, flat.Return spleen, lung meridian.

[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

The Radix Linderae:

[nature and flavor] acrid in the mouth, warm in nature. enter spleen, lung, kidney, urinary bladder channel.

[function cures mainly] is pleasant, dissipating depression of QI, cold expelling, pain relieving. cure mainly: QI rising in reverse order chest and abdomen swelling and pain, dyspepsia do not disappear, food, colic of cold type, beriberi, frequent micturition are told in regurgitation.

Bulbus Allii Macrostemonis:

[nature and flavor] acrid in the mouth; Bitter; Warm in nature;

[return through] lung; the heart; stomach; Large intestine channel;

[curing mainly] cures mainly: the thorough back of the body of obstruction of qi in the chest and cardialgia; Breast gastral cavity painful abdominal mass is vexed; Cough with asthma abundant expectoration; Epigastric pain; Heavy after letting out dysentery; leucorrhea; furunclecarbuncle.

Fructus Choerospondiatis:

[meridian distribution of property and flavor] sweet, acid, flat.

[function] circulation of qi promoting invigorate blood circulation, nourish heart, calm the nerves, anti- cardiac muscleischemia, the effects such as cardiac function protecting.For qi depression to blood stasis, the thoracic obstruction is had a pain, shortness of breath and palpitation, irritability.

Radix Aconiti Lateralis Preparata:

[nature and flavor] are pungent, sweet, hot greatly; Poisonous; GUIXIN, kidney, spleen channel.

[function] recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain." for recuperating depleted YANG and rescuing the patient from collapse first product medicine "

[curing mainly] for excessive YIN keeping YANG externally, profuse sweating yANG-depletion, vomiting and diarrhoea, it is inverse to faint, cold extremities faint pulse, trusted subordinatecold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldnessvomit and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.

Flos Albiziae:

There is calming effects, mainly control the effects such as pent-up is uncomfortable in chest, insomnia forgetfulness, nourishing YIN and invigorating YANG, ophthalmic, neurasthenia.Shu Yu, regulates the flow of vital energy, and calms the nerves, active.Control pent-up uncomfortable in chest, insomnia, forgetful, wind-fire ophthalmic, blurring of vision, pharyngalgia, carbuncle, traumatic injury pain.

Folium Coicis:

[function cures mainly-Folium Coicis effect]

1. " Bencao Tujing ": for drinking perfume (or spice), beneficial hollow diaphragm.

2. " trifling record ": the summer-heat moon decocts drink, warming the stomach, replenishing QI and blood.

There is effect of warming spleen and stomach for dispelling cold, benefiting vital QI and blood, cure mainly cold syndrome of the stomach pain, the symptom of deficient qi and blood.

Folium citri sinensis:

[nature and flavor] are pungent; Bitter; Property is put down

[return through] Liver Channel

[effect] eliminating stasis to stop pain

[effect classification] blood circulation and stasis-eliminating medicine

Cortex Caryophylli:

[nature and flavor] " detailed outline ": pungent, temperature, nontoxic.

It is swollen that [function cures mainly-Cortex Caryophylli effect] controls invasion by pathogenic cold abdominal pain, has loose bowels, toothache.

1. " Haiyao Bencao, Oversea Materia Medica ": control toothache.

2. " detailed outline ": all diseases of trusted subordinate's cold air, the Fan family is with for Flos Caryophylli.

3. " herbal classic is met former ": control abdominal distention, feel sick, have loose bowels empty sliding, indigestion.

Radix Raphani:

Radix Raphani has another name called Radix Raphani, sieve clothes.

[nature and flavor] Xin Gan is cool;

[return through] enters lung, stomach warp;

[function cures mainly] removing food stagnancy is stagnant, heat of reducing phlegm, the therapeutic method to keep the adverse QI flowing downwards, alleviating distention in middle-JIAO, removing toxic substances.Control food stagnation distension, phlegmatic cough aphonia, spit blood, epistaxis, quenches one's thirst, dysentery, migraine and general headache.

Fructus Anisi Stellati:

[meridian distribution of property and flavor] pungent, warm, return liver,kidney,spleen stomach warp;

[function cures mainly] warming YANG to expel cold, regulating QI to relieve pain.For colic of cold type stomachache, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.

Folium Ginkgo:

[meridian distribution of property and flavor] bitter in the mouth, puckery, flat; The benefit heart is astringed the lung, removing dampness antidiarrheal.

[function cures mainly] is uncomfortable in chest pained, severe palpitation, and phlegm dyspnea is coughed, dysentery, leucorrhea.

Flos Lilii viriduli:

[nature and flavor] Bulbus Lilii sweet in the mouth, cold nature; GUIXIN, lung meridian.

[function cures mainly] nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.Have nourishing YIN and moistening the lung cough-relieving effect, for the cough caused by dryness-heat of deficiency of lung-YIN, sputum mixed with blood, as all sorts of flowers cream.Control chronic cough of deficiency lung, chronic cough is spat blood, as baihe gujin decoction.Have clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep etc.

Rhizoma Zingiberis Recens:

[nature and flavor] are pungent, tepor, return lung taste warp

[effect] relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, solving toxin of fish and crab, separates poison of drug; Deliver, cold expelling, preventing or arresting vomiting, open expectorant, carbuncle skin ulcer.

Detailed description of the invention:

Embodiment 1, formula:

Radix Salviae Miltiorrhizae 10g, Olibanum 10g, Radix Glycyrrhizae Preparata 10g, Radix Angelicae Sinensis 10g, Radix Rehmanniae Preparata 10g, Herba hemipharagmatis heterophylli 10g, Pericarpium Citri grandis 10g, Caulis seu Radix Schisandrae Henryi 10g, Semen Platycladi 1g, Bulbus Allii Fistulosi 1g, Herba Gynostemmatis 1g, Radix Ophiopogonis Dracaenoidis 1g, Pericarpium Citri junoris 1g, Fructus Cucumidis sativi 1g, Herba seu Radix Calanthes 1g, Folium Mahoniae 1g, Folium Coicis 1g, Folium citri sinensis 1g, Cortex Caryophylli 1g, Radix Raphani 1g, Fructus Anisi Stellati 1g, Folium Ginkgo 1g, Flos Lilii viriduli 1g, Rhizoma Zingiberis Recens 1g, Folium Ginseng 1g, Herba Parocheti Communis 1g, Radix Astragali Preparata 1g, Radix Codonopsis 1g, Radix Linderae 1g, Bulbus Allii Macrostemonis 1g, Fructus Choerospondiatis 1g, Radix Aconiti Lateralis Preparata 1g, Flos Albiziae 1g.

Dosage form is that the preparation method of honey refining pill comprises:

A, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1

B, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.

Each 2g, every day twice 6 days is a course for the treatment of, warm water delivery service, prohibits and eats maror.

long term toxicity test:

Select SD rat, give the Chinese medicine preparation honey pill agent of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Specific embodiment 2: Lu, primary symptom: pain uncomfortable in chest is breathed hard, meets cold increasing the weight of.To hold concurrently time disease: cardiopalmus, sweating, the soreness of waist, weak, cold syndrome of the stomach cold extremities, the lips and nails being pale, or chest pain pulls the back of the body, extreme cold of the limbs, color of the lip is purple dark, faint pulse being about to disappear, or dynamicly then pants, and can not put down sleeping, puffiness of the face and dropsy of the feet.Picture of the tongue: pale tongue, or purple dark, and tongue is white.Pulse condition: heavy thin, or faint pulse being about to disappear, or heavy late thin, or knot generation.Analyze: deficiency of heart-YANG and kidney-YANG, breast sun is not transported, functional activity of QI being not smooth, and the blood stasis of blood is stagnant, therefore sensation of oppression over the chest with shortness of breath, meet cold increasing the weight of.Deficiency of heart-YANG and kidney-YANG are cardiopalmus then, sweating, and the soreness of waist is weak, aversion to cold and cold limbs, the lips and nails being pale, pale tongue, and tongue is white, deep-thready pulse.If YIN-cold is condensed, breast sun checks, and feels exogenous cold again, then chest pain pulls the back of the body, extreme cold of the limbs, and color of the lip is purple dark, faint pulse being about to disappear.Deficiency of heart-YANG and kidney-YANG, folding is not normal, and diseases caused by retention of fluid is insulted the heart and penetrated lung, dynamic then pant, and can not put down sleeping, puffiness of the face and dropsy of the feet.Purplish tongue, deep-thready pulse is slow or tie generation, is all deficiency of heart-YANG and kidney-YANG, obstruction of collaterals by blood stasis, and diseases caused by retention of fluid is insulted caused by the heart.With the present invention's honey refining pill, every day 3 times, each 2 balls, ante cibum, 30min took.The equal nothing of symptom and sign after 2 months, accuses more, after after treatment drug withdrawal in two months again, follow up a case by regular visits to 1 year, without recurrence.

Embodiment 2, formula:

Radix Salviae Miltiorrhizae 12g, Olibanum 12g, Radix Glycyrrhizae Preparata 12g, Radix Angelicae Sinensis 12g, Radix Rehmanniae Preparata 12g, Herba hemipharagmatis heterophylli 12g, Pericarpium Citri grandis 12g, Caulis seu Radix Schisandrae Henryi 12g, Semen Platycladi 2g, Bulbus Allii Fistulosi 2g, Herba Gynostemmatis 2g, Radix Ophiopogonis Dracaenoidis 2g, Pericarpium Citri junoris 2g, Fructus Cucumidis sativi 2g, Herba seu Radix Calanthes 2g, Folium Mahoniae 2g, Folium Coicis 2g, Folium citri sinensis 2g, Cortex Caryophylli 2g, Radix Raphani 2g, Fructus Anisi Stellati 2g, Folium Ginkgo 2g, Flos Lilii viriduli 2g, Rhizoma Zingiberis Recens 2g, Folium Ginseng 2g, Herba Parocheti Communis 2g, Radix Astragali Preparata 2g, Radix Codonopsis 2g, Radix Linderae 2g, Bulbus Allii Macrostemonis 2g, Fructus Choerospondiatis 2g, Radix Aconiti Lateralis Preparata 2g, Flos Albiziae 2g.

Dosage form is that the preparation method of capsule comprises:

A, by Radix Salviae Miltiorrhizae, 10 times amount ethanol put into by Radix Angelicae Sinensis and Radix Aconiti Lateralis Preparata, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, merged by 2 extracting solution and leave standstill;

B, surplus stock is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

C, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder mix homogeneously and incapsulate.

Each 2g, every day twice 6 days is a course for the treatment of, warm water delivery service, prohibits and eats maror.

acute toxicity test

Application mice carries out acute toxicity testing and shows: the capsule of Mouse oral gavage Chinese medicine composition of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

Model case: Zhang, at 65 years old age, primary symptom: stabbing pain over the chest, fixes and does not move, and increases the weight of at nightfall.

To hold concurrently time disease: chest distress and palpitation symptoms, time when doing only, with the passing of time do not heal, cause ambition severe pain because of angry.

Picture of the tongue: purplish tongue, white and thin fur.

Pulse condition: heavy.

Take Chinese medicine preparation blood circulation promoting and blood stasis dispelling of the present invention, coronary circulation-promoting pain-relieving, after one month transference cure recovery from illness, after consolidate again a treatment in month, do not recur so far.

Embodiment 3, formula:

Radix Salviae Miltiorrhizae 15g, Olibanum 15g, Radix Glycyrrhizae Preparata 15g, Radix Angelicae Sinensis 15g, Radix Rehmanniae Preparata 15g, Herba hemipharagmatis heterophylli 15g, Pericarpium Citri grandis 15g, Caulis seu Radix Schisandrae Henryi 15g, Semen Platycladi 5g, Bulbus Allii Fistulosi 5g, Herba Gynostemmatis 5g, Radix Ophiopogonis Dracaenoidis 5g, Pericarpium Citri junoris 5g, Fructus Cucumidis sativi 5g, Herba seu Radix Calanthes 5g, Folium Mahoniae 5g, Folium Coicis 5g, Folium citri sinensis 5g, Cortex Caryophylli 5g, Radix Raphani 5g, Fructus Anisi Stellati 5g, Folium Ginkgo 5g, Flos Lilii viriduli 5g, Rhizoma Zingiberis Recens 5g, Folium Ginseng 5g, Herba Parocheti Communis 5g, Radix Astragali Preparata 5g, Radix Codonopsis 5g, Radix Linderae 5g, Bulbus Allii Macrostemonis 5g, Fructus Choerospondiatis 5g, Radix Aconiti Lateralis Preparata 5g, Flos Albiziae 5g.

Dosage form is that the preparation method of tablet comprises:

By Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, 10 times amount ethanol put into by Radix Aconiti Lateralis Preparata, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, merged by 2 extracting solution and leave standstill; 10 times of water gagings put into by the surplus stock got again in above-mentioned side, heating and refluxing extraction 3 times, each 30 minutes ~ 1 hour, merged by 3 extracting solution and leave standstill; Merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.

acute toxicity test

Application mice carries out acute toxicity testing and shows: the tablet of Mouse oral gavage Chinese medicine composition of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine preparation tablet of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

Model case: so-and-so of Liu at 45 years old age, primary symptom: pain uncomfortable in chest is as stopped up, and pain draws the shoulder back of the body

To hold concurrently time disease: tired, breathe hard, limbs are heavy, abundant expectoration, time have twinge uncomfortable in chest, causalgia.

Picture of the tongue: pale tongue, thick and greasy fur, or yellow greasy.

Pulse condition: sliding.

Analyze: expectorant is YIN pathogen, deep viscous, hinders in heart arteries and veins, breast sun mistake exhibition, functional activity of QI being not smooth, therefore pain uncomfortable in chest is as stopped up.Channels, the offshoot cloth two of the heart are takeed on, and logical back of the body Yu, illegally occupies because expectorant is turbid, the venation of the retardance heart, therefore pain draws the shoulder back of the body.The turbid tired spleen of expectorant, dysfunction of the spleen in transportation, therefore limbs are heavy.Heart deficiency of spleen-QI is then tired breathes hard.Abundant expectoration, pale tongue, greasy fur, rolling pulse all the levying of the deficiency of vital energy and essential resistance of turbid phlegm.Pain of a specified duration enters network, and prolonged illness must the stasis of blood, stagnation of phlegm blood stasis, phlegm and blood stasis, then twinge time uncomfortable in chest, pain in fixed position, purplish tongue, thick and greasy fur.If expectorant turbidity is hot, combination of phlegm and heat, then causalgia time uncomfortable in chest, body of the tongue is light or secretly purple, yellow and greasy fur slippery and rapid pulse.

Take Chinese medicine preparation of the present invention activate yang let out turbid, eliminating phlegm relieving accumulation of pathogens, after one month fully recover, do not recur so far.

Embodiment 4, formula:

Radix Salviae Miltiorrhizae 18g, Olibanum 18g, Radix Glycyrrhizae Preparata 18g, Radix Angelicae Sinensis 18g, Radix Rehmanniae Preparata 18g, Herba hemipharagmatis heterophylli 18g, Pericarpium Citri grandis 18g, Caulis seu Radix Schisandrae Henryi 18g, Semen Platycladi 8g, Bulbus Allii Fistulosi 8g, Herba Gynostemmatis 8g, Radix Ophiopogonis Dracaenoidis 8g, Pericarpium Citri junoris 8g, Fructus Cucumidis sativi 8g, Herba seu Radix Calanthes 8g, Folium Mahoniae 8g, Folium Coicis 8g, Folium citri sinensis 8g, Cortex Caryophylli 8g, Radix Raphani 8g, Fructus Anisi Stellati 8g, Folium Ginkgo 8g, Flos Lilii viriduli 8g, Rhizoma Zingiberis Recens 8g, Folium Ginseng 8g, Herba Parocheti Communis 8g, Radix Astragali Preparata 8g, Radix Codonopsis 8g, Radix Linderae 8g, Bulbus Allii Macrostemonis 8g, Fructus Choerospondiatis 8g, Radix Aconiti Lateralis Preparata 8g, Flos Albiziae 8g.

Dosage form is that the preparation method of capsule comprises:

A, by Radix Salviae Miltiorrhizae, 10 times amount ethanol put into by Radix Angelicae Sinensis and Radix Aconiti Lateralis Preparata, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, merged by 2 extracting solution and leave standstill;

B, surplus stock is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

C, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder mix homogeneously and incapsulate.

Each 2g, every day twice 6 days is a course for the treatment of, warm water delivery service, prohibits and eats maror.

The present embodiment model case:

Patient is permitted XX, primary symptom: chest pain as strand, time when doing only, the cold pain of sense is very.

Double time disease: uncomfortable in chest, breathe hard, cardiopalmus, pale complexion, extremity are not warm, backache radiating to the heart.

Picture of the tongue: body of the tongue is light red, tongue is white.

Pulse condition: heavy thin.

Analyze: innate deficiency of YANG in the body, cold originating from the interior, phlegm stagnancy, breast sun checks, and feels cold-evil again, and can happen suddenly angor, because of " thoracic obstruction emergency ", therefore time stop when doing.The resistance of breast sun numbness, functional activity of QI being not smooth and uncomfortable in chest, breathes hard, cardiopalmus.Cold manifestation due to yang deficiency, does not reach four ends, therefore pallor and extremity are not warm.Tongue fur is white, and deep-thready pulse, is phlegm stagnancy, the time that yang-energy is not transported.If chest pain radiating to the back, backache radiating to the heart, deep and tense pulse person is the serious symptom of phlegm stagnancy.

Take Chinese medicine preparation activating YANG with pungent and warm drugs of the present invention, open numbness cold expelling and fully recover after one month, do not recur so far.

Embodiment 5, formula:

Radix Salviae Miltiorrhizae 20g, Olibanum 20g, Radix Glycyrrhizae Preparata 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 20g, Herba hemipharagmatis heterophylli 20g, Pericarpium Citri grandis 20g, Caulis seu Radix Schisandrae Henryi 20g, Semen Platycladi 10g, Bulbus Allii Fistulosi 10g, Herba Gynostemmatis 10g, Radix Ophiopogonis Dracaenoidis 10g, Pericarpium Citri junoris 10g, Fructus Cucumidis sativi 10g, Herba seu Radix Calanthes 10g, Folium Mahoniae 10g, Folium Coicis 10g, Folium citri sinensis 10g, Cortex Caryophylli 10g, Radix Raphani 10g, Fructus Anisi Stellati 10g, Folium Ginkgo 10g, Flos Lilii viriduli 10g, Rhizoma Zingiberis Recens 10g, Folium Ginseng 10g, Herba Parocheti Communis 10g, Radix Astragali Preparata 10g, Radix Codonopsis 10g, Radix Linderae 10g, Bulbus Allii Macrostemonis 10g, Fructus Choerospondiatis 10g, Radix Aconiti Lateralis Preparata 10g, Flos Albiziae 10g.

Dosage form is that the preparation method of honey refining pill comprises:

A, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1

B, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.

Each 2g, every day twice 6 days is a course for the treatment of, warm water delivery service, prohibits and eats maror.

The present embodiment model case: patient king XX, 56 years old, primary symptom: pain uncomfortable in chest or causalgia, cardiopalmus is vexed.

Double time disease: be insomnia, night sweat, soreness of the waist and knees, tinnitus, or have a dizzy spell, hyperhidrosis, sighing frequently, distending pain over the hypochondrium.

Picture of the tongue: deep red tongue, tongue is few or white.

Pulse condition: count accurately.

Analyze: with the passing of time disease prolongs, the deficiency of YIN and stasis, the stagnant numbness resistance of the stasis of blood, therefore see causalgia uncomfortable in chest, time when doing only.Deficiency of the kidney yin, the five internal organs lose it and moisten, heart deficiency of the kidney yin, the raw interior-heat of the deficiency of YIN, therefore see that cardiopalmus is vexed, and night sweat is insomnia, tinnitus, soreness of the waist and knees.If the kidney failing to nourish the liver, hyperactivity of YANG due to deficiency of YIN is then shown in and has a dizzy spell.If the hepatic and renal YIN deficiency, depression of liver-QI, then face is warmed, sighing frequently, distending pain over the hypochondrium.Heat is compeled antiperspirant and to be gone out then hyperhidrosis.Because of stagnation of blood stasis, thus time have breast to feel oppressed twinge.Body of the tongue red drop, have ecchymosis, tongue is few or white, thready and rapid pulse, or short, is yin asthenia generating intrinsic heat, levying of obstruction of collaterals by blood stasis.

Take invention formulation nourishing YIN for benefiting the kidney, tranquilizing by nourishing the heart is fully recovered after two months, and sign recovers normal, does not recur so far.

1 clinical data

1 clinical data

1.1 physical data choose patient with angina pectoris 100 example altogether, adopt random digits table to be divided into treatment group and matched group at random, two groups of each 50 examples, wherein treatment group 50 examples; Age 40-80 year; Matched group 50 example, age 40-80 year, two groups of ages, sex through statistical procedures, no significant difference (P>0.05).

1.2 diagnostic criteria

1.2.1 Western medicine diagnose standard is drafted with reference to " new Chinese medicine guideline of clinical investigations ".Symptom: shirtfront paroxysmal, squeezing property pain, can with other symptoms, and pain is mainly positioned at breastbone rear portion, can be radiated to pareordia and left upper extremity, work or excitedly often to occur, and each outbreak continues 3 ~ 5 minutes, can a few days once, also can one day for several times.

1.2.2 tcm diagnosis standard is with reference to " new Chinese medicine treats pained guideline of clinical investigations ".

Pained show as breastbone after or the ictal vexed pain in pareordia uncomfortable.The accidental slight chest oppressiveness of the lighter or dull pain, or unclean sense of discomfort, severe one pain is more violent, can be causalgia, angor, twinge, can take on that the back of the body is few cloudy along hands, meridian of Hand-JUE YIN follows row position and diffuses left, the persistent period is shorter, how with cardiopalmus, breathe hard, pale complexion, cold extremities due to sweating, have a rest, dispel inducement or take aromatic herbs activating YANG medicine after, pain can be alleviated.

Primary symptom 3 indispensabilities, or primary symptom 2 indispensabilities), secondary disease 2 is namely diagnosable.

1.3 case inclusive criterias are all meets two doctor's Disease Diagnosis Standards and TCM Syndrome Type diagnostic criteria and outside exclusion standard, and age person between 40-80 year all can be used as and includes case in.Participate in experimenter and all sign Informed Consent Form.

Complication is there is before the test and carries out operator in 1.4 case exclusion standards (1) in 30 hours.(2) anemia of pregnant woman, women breast-feeding their children or may conceived person at period in a medicine.(3) there are other complication to affect the treatment and observe or have the disease of taboo to observing medicine.(4) indulge in excessive drinking, smoke the person that maybe can not coordinate with dietetic regulation.(5) other organ serious diseases person that needs medication treatment is had.(6) not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.

2 Therapeutic Method

2.1 treatment groups give prescription of the present invention: embodiment 1-5 therapeutic scheme.

2.2 matched groups give to grow the heart-yin oral liquid each 10ml, and every day 2 times is oral.Storax pill for treating coronary heart disease often takes 1 ball.Each 5 of SUXIAO JIUXIN WAN, every day 3 times, oral.10 ~ 15 sublingual administrations during acute attack.

3 observation of curative effect

3.I observation item (1) tcm syndrome (primary symptom, secondary disease) observes its change every day.(2) relevant sign: blood pressure, pulse, body temperature, breathing, tongue, arteries and veins.(4) relevant physico-chemical examination, checks 1 time for 1 year afterwards.

The general health check-up project of 3.2 security inspections (1).(2) blood, urine, stool routine examination.(3) electrocardiogram, coronarography, Color Sonography function.

3.3 criterion of therapeutical effect

3．3．I

(1) cure as the basic healing of recovery from illness (two) is effective

(3) obviously progressive is that the criterion of effective (four) invalid 3.3.2 therapeutic effect of syndrome is formulated with reference to " new Chinese medicine guideline of clinical investigations " l.Statistics symptom improve integration (primary symptom is divided gently, in, heavily respectively meter 3 points, 5 points, 7 points, secondary disease counts 1 point, 2 points, 3 points respectively, asymptomatic meter zero), namely check after 1 course for the treatment of terminated, the recent cure rate of statistics iron deficiency anemia (recovery from illness and effective person are considered as healing, are designated as cure rate), total effective rate; Cure and follow up a case by regular visits to for latter 1 year, reviewing statistics relapse rate.

3.4 statistical procedures all data acquisition SPSS12.0 statistical software adds up, and before and after treatment, data compare employing x inspection and t inspection, and group is asked to compare and analyzed with Ridit.

3.5 therapeutic outcomes are in table 1-3.

Table 1 liang group total effective rate and check cure rate compare (example)

Group	n	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)	Cure rate (%)
								Treatment group	50	34	11	2	3	94	88
Matched group	50	26	12	5	7	86	86

Table 1 statistical analysis is pointed out: treatment group and the equal not statistically significant for the treatment of of control group anginal total effective rate difference (P>0.05).

A table 2 liang group Chinese medicine syndrome integral compares (x ± s, point)

Group	n	Before treatment	After treatment
				Treatment group	50	25．21±2．5	11．81±2．42
Matched group	50	24．41±1．34	12．51±2．54

Table 2 statistical analysis is pointed out: treat front two groups of integration no significant difference, after treatment, two groups of integrations are compared with before treatment, difference all has statistical significance (P<0.01), two groups of integral contrasts after treatment, difference has statistical significance (P<0.05).

After table 3 liang organizes 1 year, relapse rate compares (example)

Group	n	Recurrence	Recovery from illness	Relapse rate (%)
					Treatment group	50	5	45	10
Matched group	50	9	41	18

Table 3 statistical analysis is pointed out: treatment group relapse rate compares with matched group, and difference has statistical significance (P<0.05).

Claims (6)

1. kind of the anginal Chinese medicine preparation for the treatment of, is characterized in that: in described Chinese medicine preparation, the ratio of weight and number of various crude drug is:

Radix Salviae Miltiorrhizae 10-20 part, Olibanum 10-20 part, Radix Glycyrrhizae Preparata 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Rehmanniae Preparata 10-20 part, Herba hemipharagmatis heterophylli 10-20 part, Pericarpium Citri grandis 10-20 part, Caulis seu Radix Schisandrae Henryi 10-20 part, Semen Platycladi 1-10 part, Bulbus Allii Fistulosi 1-10 part, Herba Gynostemmatis 1-10 part, Radix Ophiopogonis Dracaenoidis 1-10 part, Pericarpium Citri junoris 1-10 part, Fructus Cucumidis sativi 1-10 part, Herba seu Radix Calanthes 1-10 part, Folium Mahoniae 1-10 part, Folium Coicis 1-10 part, Folium citri sinensis 1-10 part, Cortex Caryophylli 1-10 part, Radix Raphani 1-10 part, Fructus Anisi Stellati 1-10 part, Folium Ginkgo 1-10 part, Flos Lilii viriduli 1-10 part, Rhizoma Zingiberis Recens 1-10 part, Folium Ginseng 1-10 part, Herba Parocheti Communis 1-10 part, Radix Astragali Preparata 1-10 part, Radix Codonopsis 1-10 part, Radix Linderae 1-10 part, Bulbus Allii Macrostemonis 1-10 part, Fructus Choerospondiatis 1-10 part, Radix Aconiti Lateralis Preparata 1-10 part, Flos Albiziae 1-10 part.

2. one according to claim 1 treats anginal Chinese medicine preparation, it is characterized in that: in described Chinese medicine preparation, the ratio of weight and number of various crude drug is:

Radix Salviae Miltiorrhizae 12-18 part, Olibanum 12-18 part, Radix Glycyrrhizae Preparata 12-18 part, Radix Angelicae Sinensis 12-18 part, Radix Rehmanniae Preparata 12-18 part, Herba hemipharagmatis heterophylli 12-18 part, Pericarpium Citri grandis 12-18 part, Caulis seu Radix Schisandrae Henryi 12-18 part, Semen Platycladi 2-8 part, Bulbus Allii Fistulosi 2-8 part, Herba Gynostemmatis 2-8 part, Radix Ophiopogonis Dracaenoidis 2-8 part, Pericarpium Citri junoris 2-8 part, Fructus Cucumidis sativi 2-8 part, Herba seu Radix Calanthes 2-8 part, Folium Mahoniae 2-8 part, Folium Coicis 2-8 part, Folium citri sinensis 2-8 part, Cortex Caryophylli 2-8 part, Radix Raphani 2-8 part, Fructus Anisi Stellati 2-8 part, Folium Ginkgo 2-8 part, Flos Lilii viriduli 2-8 part, Rhizoma Zingiberis Recens 2-8 part, Folium Ginseng 2-8 part, Herba Parocheti Communis 2-8 part, Radix Astragali Preparata 2-8 part, Radix Codonopsis 2-8 part, Radix Linderae 2-8 part, Bulbus Allii Macrostemonis 2-8 part, Fructus Choerospondiatis 2-8 part, Radix Aconiti Lateralis Preparata 2-8 part, Flos Albiziae 2-8 part.

3. one according to claim 1 treats anginal Chinese medicine preparation, it is characterized in that: in described Chinese medicine preparation, the ratio of weight and number of various crude drug is:

Radix Salviae Miltiorrhizae 15 parts, Olibanum 15 parts, Radix Glycyrrhizae Preparata 15 parts, Radix Angelicae Sinensis 15 parts, Radix Rehmanniae Preparata 15 parts, Herba hemipharagmatis heterophylli 15 parts, Pericarpium Citri grandis 15 parts, Caulis seu Radix Schisandrae Henryi 15 parts, Semen Platycladi 5 parts, Bulbus Allii Fistulosi 5 parts, Herba Gynostemmatis 5 parts, Radix Ophiopogonis Dracaenoidis 5 parts, Pericarpium Citri junoris 5 parts, Fructus Cucumidis sativi 5 parts, Herba seu Radix Calanthes 5 parts, Folium Mahoniae 5 parts, Folium Coicis 5 parts, Folium citri sinensis 5 parts, Cortex Caryophylli 5 parts, Radix Raphani 5 parts, Fructus Anisi Stellati 5 parts, Folium Ginkgo 5 parts, Flos Lilii viriduli 5 parts, 5 parts, Rhizoma Zingiberis Recens, Folium Ginseng 5 parts, Herba Parocheti Communis 5 parts, Radix Astragali Preparata 5 parts, Radix Codonopsis 5 parts, the Radix Linderae 5 parts, Bulbus Allii Macrostemonis 5 parts, Fructus Choerospondiatis 5 parts, Radix Aconiti Lateralis Preparata 5 parts, Flos Albiziae 5 parts.

4. the one according to claim 1-3 any one treats anginal Chinese medicine preparation, it is characterized in that: the dosage form of described Chinese medicine preparation is that sweet preparation method of refining pill comprises:

A, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1

B, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.

5. the one according to claim 1-3 any one treats anginal Chinese medicine preparation, it is characterized in that: the dosage form of described Chinese medicine preparation is that the preparation method of capsule comprises:

A, by Radix Salviae Miltiorrhizae, 10 times amount ethanol put into by Radix Angelicae Sinensis and Radix Aconiti Lateralis Preparata, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, merged by 2 extracting solution and leave standstill;

B, surplus stock is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

C, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder mix homogeneously and incapsulate.

6. the one according to claim 1-3 any one treats anginal Chinese medicine preparation, it is characterized in that: the dosage form of described Chinese medicine preparation is that the preparation method of tablet comprises:

By Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, 10 times amount ethanol put into by Radix Aconiti Lateralis Preparata, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, merged by 2 extracting solution and leave standstill; 10 times of water gagings put into by the surplus stock got again in above-mentioned side, heating and refluxing extraction 3 times, each 30 minutes ~ 1 hour, merged by 3 extracting solution and leave standstill; Merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.