CN106983775B - Mongolian medicine spray for treating trauma and preparation method thereof - Google Patents
Mongolian medicine spray for treating trauma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Mongolian medicine spray for treating trauma and a preparation method thereof, wherein the preparation method of the Mongolian medicine spray for treating trauma comprises the following steps: (1) weighing the raw material medicines according to the weight part ratio; (2) preparing a matrix solution; (3) making into solution-gel suspension to obtain Mongolian medicinal spray; a Mongolian medicinal spray for treating trauma is prepared by a preparation method of the Mongolian medicinal spray for treating trauma. The invention has the advantages that: 1. the Mongolian medicine spray is prepared by only using mechanical force (such as shaking) without heating, the gel can be changed into sol without cooling, the sol is changed into gel after standing, and medicine particles are uniformly dispersed in the solution, so that the Mongolian medicine spray has good physical stability and ensures the medicine effect; the waste of the medicine and the pollution to the environment are avoided, the dosage is controllable, and the use efficiency of the medicine is improved; has the advantages of convenient use, short treatment course, quick response, no drug resistance and the like.
Description
The technical field is as follows:
the invention relates to a Mongolian medicine spray and a preparation method thereof, in particular to a Mongolian medicine spray for treating trauma and a preparation method thereof.
Background art:
at present, a Mongolian medicine for treating trauma is pink powder which is composed of 7 medicines such as 30-40 parts of calcite, 4-15 parts of realgar, 0.2-0.8 part of musk, 2-8 parts of concha haliotidis, 2-8 parts of vermilion, 2-8 parts of cinnabar, 20-30 parts of borneol and the like, is cool in nature and is a common prescription for treating sore throat. In the formula, realgar is mainly used for preventing corrosion, reducing swelling and healing sore; the gypsum rubrum is used for detoxifying, nourishing and regulating voxels as an auxiliary material; matching with vermilion and cinnabar to prevent corrosion and astringe, abalone shell to heal wound, dry yellow water, borneol to clear heat and musk to kill viscosity. The combination of all the medicines has the functions of detumescence, granulation promotion, convergence and sore wound healing, and has good effects on fever throat obstruction, hoarseness, throat red swelling, mouth and nose sores, skin ulceration, traumatic infection, cervical erosion and the like.
However, the common preparation form of the traditional Chinese medicine is powder, the process is laggard, the energy is not transformed when the traditional Chinese medicine is used, the medicine which is coated on a wound and sticks the wound is very few, most of the medicine is scattered and lost, and the medicine effect is greatly reduced. Moreover, the powder medicine can not be applied after wound convergence after the first medication, and the powder medicine can be taken only after being wetted by water or alcohol, so the powder is inconvenient to use and has low bioavailability; in addition, the medicine stuck on the wound after being coated on the wound is very little, the rest medicine is scattered on clothes or the periphery to cause certain pollution, and the medicine scattered on the clothes has a strong traditional Chinese medicine flavor and can influence the periphery and personal social interaction.
Because the formula consists of a plurality of minerals, medicine precipitation is easy to generate when the spray is prepared, and the concentration of the spray and the concentration of each spray are influenced, so that no stable spray exists for the formula at present.
The invention content is as follows:
the first purpose of the invention is to provide a preparation method of Mongolian medicine spray for treating trauma. Because the raw material medicines in the invention are composed of a plurality of minerals, the medicine precipitation is easy to generate when the spraying agent is prepared, and the concentration of the spraying agent and the spraying concentration of each time are influenced.
The second purpose of the invention is to provide a Mongolian medicine spray for treating trauma, which changes the prior powder into a spray preparation, overcomes the defects of the prior art, and has the characteristics of convenient use, short course of treatment, quick response, no drug resistance and the like.
The first object of the invention is realized by the following technical scheme, and the preparation method of the Mongolian medicine spray for treating the trauma comprises the following steps: (1) weighing the raw material medicines according to the weight part ratio; (2) preparing a matrix solution; (3) making into solution-gel suspension to obtain Mongolian medicinal spray; wherein the content of the first and second substances,
(1) weighing the following raw material medicines in parts by weight: weighing 30-40 parts of calcite, 4-15 parts of realgar, 0.2-0.8 part of musk, 2-8 parts of concha haliotidis, 2-8 parts of vermilion, 2-8 parts of cinnabar and 20-30 parts of borneol;
(2) preparing a matrix solution: mixing the calcite, the realgar, the musk, the abalone shell, the vermilion and the cinnabar weighed in the step (1), grinding the mixture into mixed matrix microparticles of 1-10 mu m, and dissolving the weighed borneol in 95% ethanol by mass to obtain borneol solution; adding the mixed matrix microparticles into the borneol solution, and adding water to prepare a matrix solution with the mass percentage concentration of 10% for later use;
(3) preparing solution-gel suspension finished Mongolian medicine spray: weighing 1-5 parts of aluminum stearate, 0.1-0.9 part of sodium citrate, 0.1-0.9 part of sodium hexametaphosphate, 10-20 parts of ethanol and 1-5 parts of the matrix solution according to the weight part ratio, mixing the weighed components, adding water to 100 parts, oscillating on an oscillator for 1-3 minutes to prepare the Mongolian medicine spray, and filling 30ml of the prepared Mongolian medicine spray into an injection bottle for use. The oscillator is also called as vortex device, which is used to mix the prepared solution more uniformly.
The second object of the invention is implemented by the following technical scheme, and the Mongolian medicine spray for treating the trauma is prepared by the preparation method of the Mongolian medicine spray for treating the trauma.
The invention has the advantages that: 1. the invention mainly comprises the steps that sodium citrate, sodium hexametaphosphate and aluminum stearate are mixed to form a thixotrope, and the mongolian medicine Gamuzhuer granules are suspended in a solution. The Mongolian medicine spray is prepared by only using mechanical force (such as shaking) without heating, the gel can be changed into sol without cooling, the sol is changed into gel after standing, medicine particles are uniformly dispersed in the solution, and the sedimentation speed of the Gamujuer particles obeys Stoke's law; flocculation and deflocculation: the zeta potential is within 20-25mV, the suspension is in a stable state, and the suspension has good physical stability, so that the drug effect is ensured; 2. the Mongolian medicine spray is convenient to carry and use, can be completely adsorbed on a wound when sprayed on the wound, avoids medicine waste and pollutes the environment, is controllable in dosage, and improves the use efficiency of the medicine, the existing powder is 10g in dosage, the dosage is 0.1-0.5g each time, and each bottle of medicine can be used for 20-100 times, the Mongolian medicine spray is 30ml in dosage, the Gamuzhuer net weight is 1.5g, and each bottle of medicine can be used for 1000 times; 3. the Mongolian medicine spray for treating trauma prepared by the method has the advantages of convenient use, short course of treatment, quick response, no drug resistance and the like; 4. the Mongolian medicine spray has an activating effect on fibroblast a-SMA and angiogenesis gene VEGF.
Drawings
FIG. 1 is a comparison of mouse wound models.
FIG. 2 is a chart comparing the morphological analysis of the efficacy of trauma.
FIG. 3 is a comparison of HE staining analysis of traumatized tissue.
Figure 4 is a control graph of an immunohistochemical analysis of the effect of a Mongolian spray on wound regeneration gene VEGF.
FIG. 5 is a control graph of an immunohistochemical analysis of the effect of a Mongolian spray on wound fibroblast gene a-SMA.
FIG. 6 is a graph of the effect of Mongolian sprays on wound tissue regeneration gene VEGF over time.
FIG. 7 is a graph of the effect of Mongolian sprays on wound fibroblast mRNA over time.
The specific implementation mode is as follows:
example 1: a preparation method of Mongolian medicine spray for treating trauma comprises the following steps: (1) weighing the raw material medicines according to the weight part ratio; (2) preparing a matrix solution; (3) making into solution-gel suspension to obtain Mongolian medicinal spray; wherein the content of the first and second substances,
(1) weighing the following raw material medicines in parts by weight: weighing 30 parts of calcite, 4 parts of realgar, 0.2 part of musk, 2 parts of concha haliotidis, 2 parts of vermilion, 2 parts of cinnabar and 20 parts of borneol;
(2) preparing a matrix solution: mixing the calcite, the realgar, the musk, the concha haliotidis, the vermilion and the cinnabar weighed in the step (1), grinding the mixture into mixed matrix microparticles with the particle size of 1-10 mu m, and dissolving the weighed borneol in 95% ethanol by mass to obtain borneol solution; adding the mixed matrix microparticles into the borneol solution, and adding water to prepare a matrix solution with the mass percentage concentration of 10% for later use;
(3) preparing solution-gel suspension finished Mongolian medicine spray: weighing 1 part of aluminum stearate, 0.1 part of sodium citrate, 0.1 part of sodium hexametaphosphate, 10 parts of ethanol and 1 part of matrix solution according to the weight part ratio, mixing the weighed components, adding water to 100 parts, oscillating on an oscillator for 1 minute to prepare the Mongolian medicine spray, and filling 30ml of the prepared Mongolian medicine spray into an injection bottle for use. The oscillator is also called as vortex device, which is used to mix the prepared solution more uniformly.
Example 2: a preparation method of Mongolian medicine spray for treating trauma comprises the following steps: (1) weighing the raw material medicines according to the weight part ratio; (2) preparing a matrix solution; (3) making into solution-gel suspension to obtain Mongolian medicinal spray; wherein the content of the first and second substances,
(1) weighing the following raw material medicines in parts by weight: weighing 40 parts of calcite, 15 parts of realgar, 0.8 part of musk, 8 parts of concha haliotidis, 8 parts of vermilion, 8 parts of cinnabar and 30 parts of borneol;
(2) preparing a matrix solution: mixing the calcite, the realgar, the musk, the concha haliotidis, the vermilion and the cinnabar weighed in the step (1), grinding the mixture into mixed matrix microparticles with the particle size of 1-10 mu m, and dissolving the weighed borneol in 95% ethanol by mass to obtain borneol solution; adding the mixed matrix microparticles into the borneol solution, and adding water to prepare a matrix solution with the mass percentage concentration of 10% for later use;
(3) preparing solution-gel suspension finished Mongolian medicine spray: weighing 5 parts of aluminum stearate, 0.9 part of sodium citrate, 0.9 part of sodium hexametaphosphate, 20 parts of ethanol and 5 parts of matrix solution according to the weight part ratio, mixing the weighed components, adding water to 100 parts, oscillating on an oscillator for 3 minutes to prepare the Mongolian medicine spray, and filling 30ml of the prepared Mongolian medicine spray into an injection bottle for use. The oscillator is also called as vortex device, which is used to mix the prepared solution more uniformly.
Example 3: a preparation method of Mongolian medicine spray for treating trauma comprises the following steps: (1) weighing the raw material medicines according to the weight part ratio; (2) preparing a matrix solution; (3) making into solution-gel suspension to obtain Mongolian medicinal spray; wherein the content of the first and second substances,
(1) weighing the following raw material medicines in parts by weight: weighing 35 parts of calcite, 8 parts of realgar, 0.5 part of musk, 5 parts of concha haliotidis, 5 parts of vermilion, 5 parts of cinnabar and 25 parts of borneol;
(2) preparing a matrix solution: mixing the calcite, the realgar, the musk, the concha haliotidis, the vermilion and the cinnabar weighed in the step (1), grinding the mixture into mixed matrix microparticles with the particle size of 1-10 mu m, and dissolving the weighed borneol in 95% ethanol by mass to obtain borneol solution; adding the mixed matrix microparticles into the borneol solution, and adding water to prepare a matrix solution with the mass percentage concentration of 10% for later use;
(3) preparing solution-gel suspension finished Mongolian medicine spray: weighing 3 parts of aluminum stearate, 0.5 part of sodium citrate, 0.5 part of sodium hexametaphosphate, 15 parts of ethanol and 2 parts of the matrix solution according to the weight part ratio, mixing the weighed components, adding water to 100 parts, oscillating on an oscillator for 2 minutes to prepare the Mongolian medicine spray, and filling 30ml of the prepared Mongolian medicine spray into an injection bottle for use. The oscillator is also called as vortex device, which is used to mix the prepared solution more uniformly.
Example 4: comparative test
1. The experiment treated a mouse wound model.
(1) Control group: physiological saline;
(2) positive control: yunnan Baiyao;
(3) powder preparation: gamuzhuer powder;
(4) the spraying agent is the Mongolian medicine spraying agent; the experiment treated a mouse wound model.
As shown in figure 1, the effect of the Mongolian medicine spray on treating the trauma is obviously better than that of each control group from the aspect of wound healing after 10 days of medication.
2. Morphological analysis of Gamuzhuer curative effect on trauma
(1) Powder preparation: gamuzhuer powder;
(2) the spraying agent is the Mongolian medicine spraying agent;
as shown in figure 2, the effect of Mongolian medicine spray on treating trauma is obviously better than that of powder after the application of the Mongolian medicine spray for 14 days from the condition of wound healing.
3. HE staining analysis of trauma tissue
(1) Blank: physiological saline;
(2) administration group: mongolian medicine spray
As shown in fig. 3, the recovery of epidermal tissue was significantly greater in the administered group than in the blank group 14 days after administration, as analyzed from the viewpoint of epidermal tissue generation.
4. Immunohistochemical analysis of the effects of Mongolian sprays on wound regeneration Gene VEGF
(1) Blank (K): physiological saline;
(2) administration group (Y): mongolian medicine spray
As shown in fig. 4, VEGF expression of the administered group was significantly greater than that of the blank group 14 days after the administration as analyzed from the expression of the angiogenic gene. The Mongolian medicine spray is found to have an activating effect on tissue vascular regeneration genes VEGF through immunohistochemical research.
5. Immunohistochemical analysis of the Effect of Mongolian sprays on wound fibroblast genes a-SMA
(1) Blank (K): physiological saline;
(2) administration group (Y): gamuzhuer spray
As shown in FIG. 5, the a-SMA expression in the administered group was significantly greater than that in the blank group after 14 days from the analysis of the expression of the angiogenic gene. The GamuZhuer has the activation effect on tissue fiber gene a-SMA through immunohistochemical research.
6. Effect of Mongolian medicine spray on wound tissue regeneration gene VEGF
As shown in FIG. 6, the Mongolian medicine spray is found to have up-regulation effect on tissue revascularization gene VEGF through the research on the expression level of wound tissue gene mRNA.
7. Action of Mongolian medicine spray on wound fibroblast mRNA
As shown in FIG. 7, the Mongolian medicine spraying agent is found to have up-regulation effect on the tissue revascularization gene a-SMA through research on the wound tissue gene mRNA expression level.
Claims (2)
1. A preparation method of a Mongolian medicine spray for treating trauma is characterized by comprising the following steps: (1) weighing the raw material medicines according to the weight part ratio; (2) preparing a matrix solution; (3) making into solution-gel suspension to obtain Mongolian medicinal spray; wherein the content of the first and second substances,
(1) weighing the following raw material medicines in parts by weight: weighing 30-40 parts of calcite, 4-15 parts of realgar, 0.2-0.8 part of musk, 2-8 parts of concha haliotidis, 2-8 parts of vermilion, 2-8 parts of cinnabar and 20-30 parts of borneol;
(2) preparing a matrix solution: mixing the calcite, the realgar, the musk, the abalone shell, the vermilion and the cinnabar weighed in the step (1), grinding the mixture into mixed matrix microparticles of 1-10 mu m, and dissolving the weighed borneol in 95% ethanol by mass to obtain borneol solution; adding the mixed matrix microparticles into the borneol solution, and adding water to prepare a matrix solution with the mass percentage concentration of 10% for later use;
(3) preparing solution-gel suspension finished Mongolian medicine spray: weighing 1-5 parts of aluminum stearate, 0.1-0.9 part of sodium citrate, 0.1-0.9 part of sodium hexametaphosphate, 10-20 parts of ethanol and 1-5 parts of the matrix solution according to the weight part ratio, mixing the weighed components, adding water to 100 parts, and oscillating on an oscillator for 1-3 minutes to prepare the Mongolian medicine spray.
2. A Mongolian spray for treating trauma prepared by the process of claim 1.
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