CN114832018A - Mongolian medicine patch for treating and repairing skin wound and preparation method thereof - Google Patents
Mongolian medicine patch for treating and repairing skin wound and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Mongolian medicine patch for treating and repairing skin wounds, which comprises a medicament, an adhesive tape and a medicine core; the medicament is attached to the medicament core, and the adhesive tape is wrapped on the outer surface of the medicament core; the medicine composition comprises 3 to 4 parts of calcite, 1.5 to 3 parts of borneol, 0.5 to 1.5 parts of realgar, 0.4 to 1 part of abalone shell, 0.4 to 1 part of cinnabar, 0.4 to 1 part of vermilion, 0.03 to 0.06 part of musk, 1.5 to 78 parts of tween-800.5 and 75 to 125 parts of water. The invention provides a Mongolian medicine patch for treating skin wounds and a preparation method thereof, the Mongolian medicine patch fills the gap of the Mongolian medicine patch, fully keeps the effects of oppressing and stopping bleeding of Mongolian medicine, protecting the wound surface, preventing infection and promoting healing, has better curative effect on stopping bleeding and healing of small wounds, and has the advantages of small volume, simple use, convenient carrying, reliable curative effect and the like.
Description
Technical Field
The invention relates to the technical field of medicine preparation, in particular to a Mongolian medicine patch for treating and repairing skin wounds and a preparation method thereof.
Background
In the struggle between nature and diseases, Mongolian people for hundreds of years accumulate a lot of experiences in medicine, and especially have more prominent knowledge on fracture and trauma. Abundant and various medicinal materials grow on Mongolian plateau, and diseases are prevented and treated by the medicinal materials. Many Mongolian medicines are developed in medical experience for many years, wherein the Mongolian medicine GamuZhuEr is a classic and famous prescription with definite curative effect in aspects of compression hemostasis, wound surface treatment, infection prevention and healing promotion, and has a long history.
At present, the dosage form has few varieties, and the powder is mainly applied to the affected part to bring inconvenience. Although a lot of products such as plasters and plasters are available at home and abroad at present, Mongolian medicine plaster products are not developed, and particularly Mongolian medicine plaster taking the Almuzhuer externally-applied powder which is a classical Mongolian medicine prescription as a main medicine has not been researched yet.
Therefore, the technical problem to be solved by the technical personnel in the field is to provide the gammahuer patch which is small in size, simple to use, convenient to carry and reliable in curative effect.
Disclosure of Invention
In view of the above, the invention provides a Mongolian medicine patch for treating and repairing skin wounds and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a Mongolian medicinal patch for treating and repairing skin wound comprises medicinal preparation, adhesive tape and medicinal core;
wherein the medicament is attached to the drug core, and the adhesive tape is wrapped on the outer surface of the drug core;
the medicament comprises the following raw materials in parts by weight: 3 to 4 parts of calcite, 1.5 to 3 parts of borneol, 0.5 to 1.5 parts of realgar, 0.4 to 1 part of abalone shell, 0.4 to 1 part of cinnabar, 0.4 to 1 part of vermilion, 0.03 to 0.06 part of musk, 1.5 to 1.78 parts of tween-800.5 and 75 to 125 parts of water.
Further, the adhesive tape is any one of a PVP adhesive tape, an elastic cloth, a zinc oxide adhesive tape and a PU adhesive tape.
Further, the core comprises a substrate and a water-absorbing layer;
the upper surface of the substrate is attached to the lower surface of the water absorbing layer, and the adhesive tapes wrap the lower surface of the substrate and the upper surface of the water absorbing layer of the pig respectively;
the medicament is attached to the water-absorbing layer.
Furthermore, the substrate is any one of non-woven fabrics, paper base, PE film, PVC film, PU film, EVA foam, sponge and PET film;
the water absorption layer is any one of non-woven fabrics, cotton pads and PE pad layers.
The invention also provides a preparation method of the Mongolian medicine patch for treating and repairing skin wounds, which comprises the following steps:
(1) weighing the raw materials in parts by weight;
(2) dissolving borneol in ethanol to obtain borneol liquid for later use;
(3) grinding Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, and Moschus, mixing, repeatedly extracting with ethanol, and mixing the extracts to obtain extract;
(4) mixing the obtained extract with tween-80 and water, dissolving, soaking the medicinal core in the solution, drying, and spraying Borneolum Syntheticum solution on the dried medicinal core;
(5) cutting the medicated core according to specification, and attaching adhesive tape on the outer surface of the cut medicated core to obtain Mongolian medicinal patch for treating and repairing skin wound.
Further, the ethanol in the step (2) is 75-95% ethanol by mass concentration;
the mass ratio of the borneol to the ethanol is 1.5-3: 85-115.
The beneficial effect of adopting the further scheme is that: in the experiment, 75-95% of ethanol is used for fully extracting the effective components of the borneol and ensuring the highest content, so that 75-95% of ethanol is used.
Further, the ethanol in the step (3) is ethanol with the mass concentration of 40-80%;
the extraction times are 3-6 times.
The grinding particle size is 200 meshes.
The beneficial effect of adopting the further scheme is that: in the experiment, 40 to 80 percent of ethanol is used for fully extracting the effective components of the calcite, the realgar, the cinnabar, the vermilion, the abalone shell, the musk and other medicinal materials, so that the 40 to 80 percent of ethanol is used.
Further, in the step (4), the drying temperature is 50-110 ℃, and the drying time is 30 min.
The beneficial effect of adopting the further scheme is that: by drying at 50-110 deg.C, ethanol used for extracting medicine can be sufficiently volatilized, so that high concentration ethanol can be prevented from irritating skin.
Further, the cutting specification in the step (5) is 1.6cm × 2.5cm, or 4.5cm × 6.0cm, or 2.5cm × 48 cm.
The beneficial effect of adopting the further scheme is that: experiments show that the prescription of 1.6cm multiplied by 2.5cm or 4.5cm multiplied by 6.0cm or 2.5cm multiplied by 48cm can fully maintain the effects of compressing and stanching the Mongolian medicine, protecting the wound surface, preventing infection and promoting healing, has better curative effect on stanching and healing of small wounds, and has the effects of small volume, simple use, convenient carrying, reliable curative effect and the like.
The invention has the beneficial effects that: the invention provides a Mongolian medicine patch for treating skin wounds and a preparation method thereof, the Mongolian medicine patch fills the gap of the Mongolian medicine patch, fully keeps the effects of oppressing and stopping bleeding of Mongolian medicine, protecting the wound surface, preventing infection and promoting healing, has better curative effect on stopping bleeding and healing of small wounds, and has the advantages of small volume, simple use, convenient carrying, reliable curative effect and the like.
Drawings
FIG. 1 is a histogram of the area of skin wound remaining in rats (notation: comparison with model group: P < 0.05);
FIG. 2 is a graph showing the area of the wound left on the skin of a rat;
FIG. 3 is a graph of HE staining (HE X200) for wound recovery in rats;
FIG. 4 is a graph of rabbit skin irritant HE staining (HE X200).
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Examples
A Mongolian medicinal patch for treating and repairing skin wound comprises medicinal preparation, adhesive tape and medicinal core;
wherein the medicament is attached to the medicament core, and the adhesive tape is wrapped on the outer surface of the medicament core;
in one embodiment, the adhesive tape is any one of a PVP adhesive tape, a stretch cloth, a zinc oxide adhesive tape and a PU adhesive tape.
In one embodiment, the core comprises a substrate and a water-absorbing layer;
the upper surface of the substrate is attached to the lower surface of the water absorbing layer, and the adhesive tapes wrap the lower surface of the pig substrate and the upper surface of the water absorbing layer respectively;
the medicament is attached to the water-absorbing layer.
In another embodiment, the substrate is any one of non-woven fabric, paper base, PE film, PVC film, PU film, EVA foam, sponge, and PET film;
the water absorption layer is any one of non-woven fabrics, cotton pads and PE pad layers.
Example 1
The preparation method of the Mongolian medicine patch for treating and repairing skin wound comprises the following steps:
(1) weighing 3g of calcite, 1.5g of borneol, 0.5g of realgar, 0.4g of concha haliotidis, 0.4g of cinnabar, 0.4g of vermilion, 0.03g of musk, 0.8978 g of tween-800.5 and 75g of water;
(2) dissolving borneol in 85ml of 75% ethanol with mass concentration to obtain borneol liquid for later use;
(3) grinding Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, and Moschus to 200 mesh, mixing, extracting with 40% ethanol repeatedly for 6 times, and mixing the extracts to obtain extract;
(4) mixing the obtained extract with tween-80 and water, dissolving, soaking the medicinal core in the solution, drying at 50 deg.C for 30min, and spraying Borneolum Syntheticum solution onto the dried medicinal core;
(5) cutting the medicated core, and attaching adhesive tape to the outer surface of the cut medicated core to obtain Mongolian medicinal patch for treating and repairing skin wound.
Example 2
The preparation method of the Mongolian medicine patch for treating and repairing skin wound comprises the following steps:
(1) weighing 4g of calcite, 3g of borneol, 1.5g of realgar, 01g of concha haliotidis, 1g of cinnabar, 1g of vermilion, 0.06g of musk, 801.5 g of tween-and 125g of water;
(2) dissolving borneol in 115ml of ethanol with the mass concentration of 95% to obtain borneol liquid for later use;
(3) grinding Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, and Moschus to 200 mesh, mixing, extracting with 80% ethanol repeatedly for 3 times, and mixing the extracts to obtain extract;
(4) mixing the obtained extract with tween-80 and water, dissolving, soaking the medicinal core in the solution, drying at 110 deg.C for 30min, and spraying Borneolum Syntheticum solution on the dried medicinal core;
(5) cutting the medicated core, and attaching adhesive tape to the outer surface of the cut medicated core to obtain Mongolian medicinal patch for treating and repairing skin wound.
Example 3
The preparation method of the Mongolian medicine patch for treating and repairing skin wound comprises the following steps:
(1) weighing 3.5g of calcite, 2.2g of borneol, 1.2g of realgar, 0.8g of concha haliotidis, 0.6g of cinnabar, 0.7g of vermilion, 0.04g of musk, 800.9 g of tween-800.9 and 100g of water;
(2) dissolving borneol in 100ml of ethanol with the mass concentration of 85% to obtain borneol liquid for later use;
(3) grinding Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, and Moschus to 200 mesh, mixing, extracting with 60% ethanol repeatedly for 4 times, and mixing the extracts to obtain extract;
(4) mixing the obtained extract with tween-80 and water, dissolving, soaking the medicinal core in the solution, drying at 85 deg.C for 30min, and spraying Borneolum Syntheticum solution on the dried medicinal core;
(5) cutting the medicated core, and attaching adhesive tape to the outer surface of the cut medicated core to obtain Mongolian medicinal patch for treating and repairing skin wound.
Test example 1
1. Experimental materials and instruments
1.1 Experimental animals
Male Wistar rat weighing 180-220 g
1.2 Experimental drugs and instruments
The extract prepared in example 1 was used to prepare various concentrations of adhesive bandages, blank matrix adhesive bandages, gauze, 10% chloral hydrate, 8% sodium sulfide, iodine, 4% paraformaldehyde, paraffin, xylene, 95% ethanol, 90%, 80% ethanol, modified Harris hematoxylin, 1% ethanol hydrochloride, a red staining solution, surgical scissors, and a scalpel.
2.1 preparation of the adhesive bandage
Preparing the woundplast with low, medium and high concentrations: 0.5g, 1g and 1.5g of the extract prepared in the embodiment 1 are precisely weighed, then 0.2g, 0.4g, 0.6g of linseed oil, 0.2g, 0.4g, 0.6g of glycerol and 20ml of 60% ethanol are respectively added, evenly mixed and stirred, and 55 pieces of cotton are soaked and dried in the sun.
2.2 Experimental animals and modeling
After 72 Wistar rats weighing 180-200 g are adaptively fed for one week, the backs of the rats are unhaired one day before the experiment, and the weights of the rats are weighed. Circular full-thickness incised wounds of approximately 0.6cm x 0.6 wound surface were created by dorsal iodophor sterilization of each rat following intraperitoneal injection of 0.3ml/100g of anaesthesia with 10% chloral hydrate. All wounded rats were treated immediately after preparation of the damaged skin surface for 9 consecutive days. The wounded parts of rats in each group were photographed 3, 5, 7, and 9 days after the operation, and the data of the wounded residual area of the rats were recorded. And taking tissue samples for HE staining 3, 5, 7 and 9 days after the operation. Histopathological features were observed under a normal light microscope.
2.3 methods of grouping and administering drugs
Model group (group a), blank matrix group (group B), powder group (group C, dried powder of the extract prepared in example 1), low dose adhesive bandage group (group D), medium dose adhesive bandage group (group E), high dose adhesive bandage group (group F) each group of 3 Wistar rats, adhesive bandage for 9 days.
2.2.2 evaluation of wound recovery
The back sore state of the rat is observed every day, the wound of the rat is photographed on 3 rd, 5 th, 7 th and 9 th days after the model is successfully built, the shrinkage rate is calculated, the wound residual area of the rat is recorded, and the calculation is carried out by using Image software. Data were statistically analyzed using SPSS22.0 software.
2.2.3 Observation of wound pathological tissue
3 rats were sacrificed from each group on days 3, 5, 7, and 9, and the skin of the back wound was excised with a wound centered at approximately 1.5cm radius, fixed with 4% paraformaldehyde solution for 24h, and dehydrated with ethanol of various concentrations after washing with distilled water. After embedding with paraffin, 5 μm sections were made.
HE staining: paraffin section dewaxing to water: sequentially placing the slices in xylene I for 10min, xylene II for 10min, anhydrous ethanol I for 5min, anhydrous ethanol II for 5min, 95% ethanol for 5min, 90% ethanol for 5min, 80% ethanol for 5min, 70% ethanol for 5min, and washing with distilled water.
② hematoxylin staining cell nucleus: slicing into Harris hematoxylin, staining for 3-8min, washing with tap water, differentiating with 1% hydrochloric acid alcohol for several seconds, washing with tap water, returning blue with 0.6% ammonia water, and washing with running water.
③ eosin staining cytoplasm: the sections were stained in eosin stain for 1-3 min.
Fourthly, dewatering and sealing: placing the slices in 95% alcohol I5 min-95% alcohol II 5 min-anhydrous ethanol I5 min-anhydrous ethanol II 5min, xylene I5 min-xylene II 5min, dehydrating and transparentizing in 5min, taking out the slices from xylene, air drying, and sealing with neutral gum.
And fifthly, microscopic examination and image acquisition and analysis.
3. Results of the experiment
3.1 Table 1 recovery from skin trauma in rats
(Note: comparison with model group: P < 0.05)
The wound area of the adhesive bandage is reduced and scars are formed at the wound position on the 3 rd day, and compared with the medium-dose adhesive bandage group, the high-dose adhesive bandage group, the low-dose adhesive bandage group and the high-dose adhesive bandage group, and the powder group and the high-dose adhesive bandage group, the statistical significance is achieved (p is less than 0.05). The higher dose gawoundplast group was statistically insignificant to the model group (p > 0.05). The wounds of rats in each group were reduced starting on day 5, and the skin wounds of rats in the medium dose adhesive bandage group and the blank matrix group were slightly reddened. No statistical significance exists between the medium-dose band-aid group and the low-dose band-aid group, the powder group and the model group (p is more than 0.05). Rats were less and less traumatic starting on day 7, and the low dose woundplast group was statistically significant compared to the other dose groups (p < 0.05). Compared with the powder group, the medium-dose woundplast group has no statistical significance (p is more than 0.05).
3.1.2 HE staining method for evaluating skin wound repair condition of rats
On the 3 rd day after scratching, a large number of inflammatory and apoptotic tissues including macrophages, neutrophils, monocytes, exfoliated and lysed nuclei and the like were found from each group of pictures. The high-dose band-aid group and the powder group have serious inflammation infiltration, a small amount of neovascularization appears around the wound of a rat in the low-dose band-aid group, the medium-dose band-aid group and the high-dose band-aid group, and epithelial cells appear around the wound of a rat in the blank stroma group.
On day 5, the low, medium and high dose adhesive bandages were used, and the blank matrix group included macrophages, neutrophils, monocytes, exfoliated and lysed nuclei and a large amount of inflammation and apoptotic tissue reduction. The wound inflammation of the high-dose woundplast group and the powder group is serious. Newly generated blood vessels of each group are increased, a large amount of newly generated tissues of the low-dose band-aid group and the powder group are increased, the number of fibers is increased, and epithelial cells are generated around the wounds of the rats of the low-dose band-aid group and the blank stroma group.
On day 7 of the application of the band-aid, as shown in the figure, the epithelial structure of the low-dose band-aid group is nearly repaired, newly generated blood vessels are reduced, and the bottom layer, the horn layer, the granular layer, the horn layer and a large amount of muscle tissues can be distinguished and replaced by collagen fibers secreted by fiber cells. The medium and high dose woundplast group and the powder group began to generate muscle tissue, and a large amount of fiber cells appeared. The blank matrix group still had little inflammation and little muscle tissue formation.
On day 9 of the application of the bandage, the low-dose groups of the bandage showed complete epidermal structures, new blood vessels and muscle tissues were formed, fibroblasts were decreased, and collagen fibers were increased. The skin-related organs began to appear and the newly formed skin was already close to normal levels. The powder group epidermal structure has approached normal levels and a large amount of muscle tissue is replaced by collagen fibers secreted by the fibroblasts. A large amount of granulation tissues still exist in the medium and high dose band-aid groups and the blank matrix group, and generated fibroblasts begin to secrete collagen fibers.
Compared with the high-dose band-aid group, the low-dose band-aid group and the high-dose band-aid group have statistical significance (P is less than 0.05) in the difference between the powder group and the high-dose band-aid group on the 3 rd and 5 th days after operation. The difference between the low-dose band-aid groups at 7 th and 9 th days is statistically significant (P is less than 0.05). Observed under an optical microscope to find that: compared with the model group, the low-dose band-aid group has the advantages of light inflammatory reaction and more new granulation tissues. The low-dose band-aid group was compared with the high-dose band-aid group,
inflammation is reduced earlier, granulation tissue appears earlier, and the time for the skin to recover the complete structure is shorter. The low-dose band-aid group has the smallest wound residual area and the best healing effect.
Summary of the invention
The wound of the rat can be rapidly repaired due to the effects of repairing the wound and diminishing inflammation. The residual wound areas of the medium-dose band-aid group and the powder group have no obvious difference, so that the medium-dose band-aid and the powder can be proved to have the same effect. The low-dose adhesive bandage has better drug effect than the medium dose, so the low-dose adhesive bandage can play the drug effect faster than powder in the aspect of repairing the wound.
Test example 2 test of skin irritation and allergy of the adhesive bandage
1. Experimental materials and instruments
1.1 Experimental animals
Rabbits with the weight of 2.0-2.5 kg in common grade, Dutch pigs with the weight of 250.0-300.0 g in common grade, and experimental animals are respectively raised in a cage.
1.2 instruments and drugs
Surgical scissors, scalpel, band-aid, blank matrix band-aid, 8% sodium sulfide, positive control group (1, 2 dinitrochlorobenzene)
2. Irritation test
2.1 modeling of Normal skin
Normal skin of rabbits is the key to the experiment. 4-24 h before administration, cutting off hair on the back of the rabbit, softening the hair with 8% sodium sulfide, washing with water at 40 ℃, and wiping with gauze for experimental observation. After 24h, the wound was examined.
2.2 methods of administration
The high, medium and low dosage woundplast groups and the blank matrix woundplast (2cm multiplied by 2cm) are stuck on the normal skin of the back of the rabbit.
Single contact experiments: the patch was fixed to the depilating portion 4 h. After the contact period is complete, the patch is removed, washed with warm water or other suitable non-irritating solvent and carefully wiped dry. After removing the patches for 4h, the condition of each contact site was recorded.
The contact experiment was repeated: this experiment was repeated after completion of a single contact trial, 4h per day for 3d observation and recording. The contact site was recorded after each patch removal and before re-contact. After the last contact, the contact site condition was recorded after removal of the patch, respectively.
2.3 Observation index and evaluation Standard
Observation indexes are as follows: visually observing the degrees and the range of the erythema, the edema and the hyperemia of the local skin of the rabbit, and expressing the degrees and the range by a scoring mode; meanwhile, the general state, behavior, physical signs and the like of the rabbits are observed. HE staining was performed after the experiment was completed. The morphological changes of the skin tissue after the application of the drug were observed under a microscope.
Table 2 evaluation criteria table for skin irritation degree
| Categories | Scoring |
| Has no |
0～0.49 |
| Slightly irritating | 0.5～2.99 |
| Moderate irritation | 3.0～5.99 |
| Severe irritation | 6.0～8 |
Table 3 evaluation criteria table for skin irritation
3. Allergy test
3.1 skin modeling
The normal intact skin of the guinea pig is the key to the experiment. The back hair of the Dutch pigs is shaved after being softened by 8% sodium sulfide solution 4-24 h before administration, and the Dutch pigs are washed by water at 40 ℃ and wiped by gauze for later use.
3.2 methods of administration
Sensitization and contact: the patch group, the matrix group, and the positive control (1% 2, 4-dinitrochlorobenzene) were applied to the left side of the back of guinea pigs for 8 hours, and the same procedure was repeated 1 time on day 7 and 14.
And (3) exciting contact: and respectively applying the test substances to the right depilated area of the corresponding animal 14 days after the test substances are sensitized for the last time, removing the test substances after 8 hours, observing the skin allergy reaction conditions again after 24 hours, 48 hours and 72 hours, grading according to the grading standard of the skin allergy degree, and calculating the average reaction value of each group of animals.
TABLE 4 evaluation criteria for skin allergy
| Probability of allergic reaction (%) | Rank of | Extent of |
| 0～10 | I | No anaphylaxis |
| 11～30 | II | Mild hypersensitivity |
| 31～60 | III | Moderate hypersensitivity |
| 61～80 | IV | Severe hypersensitivity |
| 81～100 | V | Severe hypersensitivity |
TABLE 5 evaluation criteria for skin allergy
4. Results
The phenomenon of erythema, edema and the like is not observed by naked eyes. The administration group is observed under an HE staining light mirror without damaging the epidermis and the dermis of the rabbit, the thickness is unchanged, and no inflammatory exudation is seen. The guinea pigs have no red swelling or water spot. The patch has no irritation and allergy.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
Claims (9)
1. A Mongolian medicinal patch for treating and repairing skin wound is characterized by comprising a medicament, an adhesive tape and a medicinal core;
wherein the medicament is attached to the drug core, and the adhesive tape is wrapped on the outer surface of the drug core;
the medicament comprises the following raw materials in parts by weight: 3 to 4 parts of calcite, 1.5 to 3 parts of borneol, 0.5 to 1.5 parts of realgar, 0.4 to 1 part of abalone shell, 0.4 to 1 part of cinnabar, 0.4 to 1 part of vermilion, 0.03 to 0.06 part of musk, 1.5 to 1.78 parts of tween-800.5 and 75 to 125 parts of water.
2. The Mongolian medicinal patch for treating and repairing skin wound according to claim 1, wherein the adhesive tape is any one of PVP adhesive tape, stretch cloth, zinc oxide adhesive tape and PU adhesive tape.
3. The transdermal patch of claim 1, wherein the core comprises a base and a water-absorbing layer;
the upper surface of the substrate is attached to the lower surface of the water absorbing layer, and the adhesive tapes are respectively wrapped on the lower surface of the substrate and the upper surface of the water absorbing layer;
the medicament is attached to the water-absorbing layer.
4. The patch for treating and repairing skin wounds of claim 3, wherein the substrate is any one of a non-woven fabric, a paper base, a PE film, a PVC film, a PU film, an EVA foam, a sponge and a PET film;
the water absorption layer is any one of non-woven fabrics, cotton pads and PE pad layers.
5. A preparation method of a Mongolian medicine patch for treating and repairing skin wound is characterized by comprising the following steps:
(1) weighing the raw materials according to the parts by weight of any one of claims 1 to 4;
(2) dissolving borneol in ethanol to obtain borneol liquid for later use;
(3) grinding Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, and Moschus, mixing, repeatedly extracting with ethanol, and mixing the extracts to obtain extract;
(4) mixing the obtained extract with tween-80 and water, dissolving, soaking the medicinal core in the solution, drying, and spraying Borneolum Syntheticum solution on the dried medicinal core;
(5) cutting the medicated core according to specification, and attaching adhesive tape on the outer surface of the cut medicated core to obtain Mongolian medicinal patch for treating and repairing skin wound.
6. The preparation method of the Mongolian medicine patch for treating and repairing skin wound according to claim 5, wherein the ethanol in the step (2) is 75-95% by mass;
the mass ratio of the borneol to the ethanol is 1.5-3: 85-115.
7. The preparation method of the Mongolian medicine patch for treating and repairing skin wound according to claim 5, wherein the ethanol in the step (3) is ethanol with the mass concentration of 40% -80%;
the extraction times are 3-6 times;
the grinding particle size is 200 meshes.
8. The method for preparing Mongolian patch for the treatment and repair of skin wound according to claim 5, wherein the drying temperature in step (4) is 50-110 deg.C, and the drying time is 30 min.
9. The method for preparing Mongolian patch for the treatment and repair of skin wound according to claim 5, wherein said cutting specification in step (5) is 1.6cm x 2.5cm or 4.5cm x 6.0cm or 2.5cm x 48 cm.
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| CN202210340815.9A CN114832018A (en) | 2022-04-06 | 2022-04-06 | Mongolian medicine patch for treating and repairing skin wound and preparation method thereof |
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| CN202210340815.9A CN114832018A (en) | 2022-04-06 | 2022-04-06 | Mongolian medicine patch for treating and repairing skin wound and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1339312A (en) * | 2001-09-13 | 2002-03-13 | 云南白药集团天然药物研究院 | Wound plaster of yannan Baiyao and its preparing method |
| CN106983775A (en) * | 2016-01-19 | 2017-07-28 | 毕力格 | It is a kind of to treat anaesthetic spray of wound and preparation method thereof |
| KR20170098676A (en) * | 2016-02-22 | 2017-08-30 | 랜기어 테크놀로지 컴퍼니 리미티드 | Chinese medicine for treating wounded skin |
| CN108653377A (en) * | 2018-07-04 | 2018-10-16 | 阿拉腾其木格 | A kind of mongolian medicine patch and preparation method for treating skin trauma |
-
2022
- 2022-04-06 CN CN202210340815.9A patent/CN114832018A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1339312A (en) * | 2001-09-13 | 2002-03-13 | 云南白药集团天然药物研究院 | Wound plaster of yannan Baiyao and its preparing method |
| CN106983775A (en) * | 2016-01-19 | 2017-07-28 | 毕力格 | It is a kind of to treat anaesthetic spray of wound and preparation method thereof |
| KR20170098676A (en) * | 2016-02-22 | 2017-08-30 | 랜기어 테크놀로지 컴퍼니 리미티드 | Chinese medicine for treating wounded skin |
| CN108653377A (en) * | 2018-07-04 | 2018-10-16 | 阿拉腾其木格 | A kind of mongolian medicine patch and preparation method for treating skin trauma |
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