CN101683510A - Chinese medicine patch for treating cold and pain and method for producing the same - Google Patents
Chinese medicine patch for treating cold and pain and method for producing the same Download PDFInfo
- Publication number
- CN101683510A CN101683510A CN200810151803A CN200810151803A CN101683510A CN 101683510 A CN101683510 A CN 101683510A CN 200810151803 A CN200810151803 A CN 200810151803A CN 200810151803 A CN200810151803 A CN 200810151803A CN 101683510 A CN101683510 A CN 101683510A
- Authority
- CN
- China
- Prior art keywords
- crude drug
- pain
- adopts
- rhizoma
- proportion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Abstract
The invention provides a Chinese medicine patch for treating cold and pain and a method for producing the same, and the invention contains the following components in proportion by weight: notopterygium root 5-10, windproof 3-10, ginger 3-10; the invention includes the steps of: proportionally mixing raw materials, grinding until particle diameter of each component is 100-200 mu m; using CO2 supercritical extraction, fractionating acquired distillates with a fractionating tower, mixing each component in the formula into nano medicinal pulp according to the formula proportionality through the nano dispersing apparatus, adding accelerating agent for percutaneous absorption and contact adhesive into the circular type low temperation drying coater, and after coating, executing shearing, quality test, packaging and then sending the product into warehouse. The invention uses a scientific method for processing and extracting medicinal materials, which are filled in the framework of the substrate, and the paster substrate has a good compatibility with skin, and is good for medicament molecule to pass; the medicament has the advantages of slow release, smooth and steady administration, small irritation without toxic and side effects, thereby resolving the problem that oral medication and injection have toxic and side effects for human body and preventing toxic and side effects of medicament taken orally.
Description
Technical field
The present invention relates to a kind of Chinese herbs paste, relate in particular to the Chinese herbs paste and the manufacture method of a kind of treatment flu and pain.
Background technology
Flu is the most common frequently-occurring disease.Doctor trained in Western medicine thinks that flu is that virus causes, the antipyretic analgesic that treatment means mainly is antiviral agents, vaccine, suit the medicine to the illness; It is generally acknowledged common cold treatment and not treating all needs the week age recovery from illness, even has the people to do statistics, and the result shows that the effect of treatment and the effect of not treating are equal to, even not as good as not treating.And the traditional Chinese medical science thinks that flu is that the exopathogen invasion causes with endogenous dampness stasis institute, and the method for treatment should be from effecting a permanent cure.After general patient catches a cold, adopt medicament to treat usually, mostly be oral drugs or injection, but the equal toxic side effect of oral drugs and injection, can produce through liver first-pass effect and gastrally release light reaction, so just bring safety problem to the patient.
Summary of the invention
Main purpose of the present invention is to solve the toxic and side effects that oral drugs and injection bring human body, provide a kind of toxic and side effects of having avoided oral administration to use, also without liver first-pass effect and the gastral light treatment flu and the Chinese herbs paste and the manufacture method of pain released.
The technical solution adopted for the present invention to solve the technical problems is:
The treatment flu is made according to following method with the Chinese herbs paste of pain and the crude drug that manufacture method is following column weight amount proportioning part: Rhizoma Et Radix Notopterygii 5-10 part, Radix Saposhnikoviae 3-10 part, Rhizoma Zingiberis Recens 3-10 part.
Get in proportion Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Rhizoma Zingiberis Recens broken respectively, grind, the particle diameter by each composition behind micron homogenizer and the nanometer homogenizer homogenizing is 100-200 μ m.
Behind the quality inspection particle diameter, ground crude drug is dropped into colloid mill respectively and carry out CO
2Supercritical extraction adds beta-schardinger dextrin-and an amount of water, and the weight ratio of crude drug and beta-schardinger dextrin-is 1: 6.Colloid mill evenly grinds, and maintenance speed is 3000r/min, and regulating the mill spacing is 5 μ m, slowly is added dropwise to the composition of the crude drug of an amount of dissolve with ethanol continuously, behind the immersion 6h, at 4C Celsius ° of following cold preservation 24h, evacuation.At 40C Celsius ° of following vacuum drying, with a spot of water and washing with alcohol 3 times, carry out drying with 40C ° of return air, obtain clathrate; The remove enclose method adopts methylene chloride reflux to extract 30min.
Change tooth and the relative motion of deciding between the tooth by taper, be subjected to effects such as shearing, stirring, grinding when making material, make enclose object threading beta-schardinger dextrin-cavity, thereby reach the enclose effect by adjustable gap.Adopt colloid milling prepare the Benexate Hydrochloride enclose time short, energy consumption is low, product yield height, process conditions are easy to control, are fit to large-scale production.
Confirm through check, each crude drug is mixed in proportion, add dressing 8-10 part, surfactant 3-6 part, stirring is mixed with nanometer medicine slurry.
In nanometer medicine slurry, add Percutaneous absorption enhancer 0.3-0.5 part and gel matrix 3-5 part, send into spiral fashion so cold drying coating machine after stirring, be coated on cloth or non-woven fabrics or polyethylene sheets; Coating back drying, sterilization, sterilization, shearing, quality inspection, the finished product packing warehouse-in.
Dressing is Kaolin, bentonite, zinc oxide, titanium dioxide, adopts more than one at least.Promoter is methyl salicylate, Camphora, Mentholum, adopts more than one at least.Gel matrix is pressure sensitive adhesive, resin glue, rubber, adopts more than one at least.
The specific embodiment
Embodiment 1 (high dose)
The Chinese herbs paste of treatment flu and pain and manufacture method be crude drug by weight ratio every part in 1kg, make according to following method: Rhizoma Et Radix Notopterygii 10kg, Radix Saposhnikoviae 10kg, Rhizoma Zingiberis Recens 10kg.
Get in proportion Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Rhizoma Zingiberis Recens broken respectively, grind, the particle diameter by each composition behind micron homogenizer and the nanometer homogenizer homogenizing is 100-200 μ m.
Behind the quality inspection particle diameter, ground crude drug is dropped into colloid mill respectively and carry out CO
2Supercritical extraction adds beta-schardinger dextrin-and an amount of water, and the weight ratio of crude drug and beta-schardinger dextrin-is 1: 6.Colloid mill evenly grinds, and maintenance speed is 3000r/min, and regulating the mill spacing is 5 μ m, slowly is added dropwise to the composition of the crude drug of an amount of dissolve with ethanol continuously, behind the immersion 6h, at 4C Celsius ° of following cold preservation 24h, evacuation.At 40C Celsius ° of following vacuum drying, with a spot of water and washing with alcohol 3 times, carry out drying with 40C ° of return air, obtain clathrate; The remove enclose method adopts methylene chloride reflux to extract 30min.
Confirm through check, each crude drug is mixed in proportion, add dressing 10kg, surfactant 6kg, stirring is mixed with nanometer medicine slurry.
In nanometer medicine slurry, add Percutaneous absorption enhancer 0.5kg and gel matrix 5kg, send into spiral fashion so cold drying coating machine after stirring, be coated on cloth or non-woven fabrics or polyethylene sheets; Coating back drying, sterilization, sterilization, shearing, quality inspection, the finished product packing warehouse-in.
Dressing is Kaolin, bentonite, zinc oxide, titanium dioxide, adopts more than one at least.Promoter is methyl salicylate, Camphora, Mentholum, adopts more than one at least.Gel matrix is pressure sensitive adhesive, resin glue, rubber, adopts more than one at least.
Embodiment 2 (low dosage)
The Chinese herbs paste of treatment flu and pain and manufacture method be crude drug by weight ratio every part in 1kg, make according to following method: Rhizoma Et Radix Notopterygii 5kg, Radix Saposhnikoviae 3kg, Rhizoma Zingiberis Recens 3kg.
Get in proportion Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Rhizoma Zingiberis Recens broken respectively, grind, the particle diameter by each composition behind micron homogenizer and nanometer homogenizer and the nanometer homogenizer homogenizing is 100-200 μ m.
Behind the quality inspection particle diameter, ground crude drug is dropped into colloid mill respectively and carry out CO
2Supercritical extraction adds beta-schardinger dextrin-and an amount of water, and the weight ratio of crude drug and beta-schardinger dextrin-is 1: 6.Colloid mill evenly grinds, and maintenance speed is 3000r/min, and regulating the mill spacing is 5 μ m, slowly is added dropwise to the composition of the crude drug of an amount of dissolve with ethanol continuously, behind the immersion 6h, at 4C Celsius ° of following cold preservation 24h, evacuation.At 40C Celsius ° of following vacuum drying, with a spot of water and washing with alcohol 3 times, carry out drying with 40C ° of return air, obtain clathrate; The remove enclose method adopts methylene chloride reflux to extract 30min.
Confirm through check, each crude drug is mixed in proportion, add dressing 8kg, surfactant 3kg, stirring is mixed with nanometer medicine slurry.
In nanometer medicine slurry, add Percutaneous absorption enhancer 0.3kg and gel matrix 3kg, send into spiral fashion so cold drying coating machine after stirring, be coated on cloth or non-woven fabrics or polyethylene sheets; Coating back drying, sterilization, sterilization, shearing, quality inspection, the finished product packing warehouse-in.
Dressing is Kaolin, bentonite, zinc oxide, titanium dioxide, adopts more than one at least.Promoter is methyl salicylate, Camphora, Mentholum, adopts more than one at least.Gel matrix is pressure sensitive adhesive, resin glue, rubber, adopts more than one at least.
Embodiment 3 (median dose)
The Chinese herbs paste of treatment flu and pain and manufacture method be crude drug by weight ratio every part in 1kg, make according to following method: Rhizoma Et Radix Notopterygii 7.5kg, Radix Saposhnikoviae 6.5kg, Rhizoma Zingiberis Recens 6.5kg.
Get in proportion Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Rhizoma Zingiberis Recens broken respectively, grind, the particle diameter by each composition behind micron homogenizer and the nanometer homogenizer homogenizing is 100-200 μ m.
Behind the quality inspection particle diameter, ground crude drug is dropped into colloid mill respectively and carry out CO
2Supercritical extraction adds beta-schardinger dextrin-and an amount of water, and the weight ratio of crude drug and beta-schardinger dextrin-is 1: 6.Colloid mill evenly grinds, and maintenance speed is 3000r/min, and regulating the mill spacing is 5 μ m, slowly is added dropwise to the composition of the crude drug of an amount of dissolve with ethanol continuously, behind the immersion 6h, at 4C Celsius ° of following cold preservation 24h, evacuation.At 40C Celsius ° of following vacuum drying, with a spot of water and washing with alcohol 3 times, carry out drying with 40C ° of return air, obtain clathrate; The remove enclose method adopts methylene chloride reflux to extract 30min.
Confirm through check, each crude drug is mixed in proportion, add dressing 9kg, surfactant 4.5kg, stirring is mixed with nanometer medicine slurry.
In nanometer medicine slurry, add Percutaneous absorption enhancer 0.4kg and gel matrix 4kg, send into spiral fashion so cold drying coating machine after stirring, be coated on cloth or non-woven fabrics or polyethylene sheets; Coating back drying, sterilization, sterilization, shearing, quality inspection, the finished product packing warehouse-in.
Dressing is Kaolin, bentonite, zinc oxide, titanium dioxide, adopts more than one at least.Promoter is methyl salicylate, Camphora, Mentholum, adopts more than one at least.Gel matrix is pressure sensitive adhesive, resin glue, rubber, adopts more than one at least.
Claims (3)
1, a kind of Chinese herbs paste for the treatment of flu and pain, it is characterized in that being: it is made up of following weight proportion component: Rhizoma Et Radix Notopterygii 5-10 part, Radix Saposhnikoviae 3-10 part, Rhizoma Zingiberis Recens 3-10 part.
2, a kind of flu and the Chinese herbs paste and manufacture method of pain for the treatment of is characterized in that: it is that the crude drug of following column weight amount proportioning part is made according to following method: Rhizoma Et Radix Notopterygii 5-10 part, Radix Saposhnikoviae 3-10 part, Rhizoma Zingiberis Recens 3-10 part; Get in proportion Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Rhizoma Zingiberis Recens broken respectively, grind, the particle diameter by each composition behind micron homogenizer and the nanometer homogenizer homogenizing is 100-200 μ m; Behind the quality inspection particle diameter, ground crude drug is dropped into colloid mill respectively and carry out CO
2Supercritical extraction adds beta-schardinger dextrin-and an amount of water, and the weight ratio of crude drug and beta-schardinger dextrin-is 1: 6; Colloid mill evenly grinds, and maintenance speed is 3000r/min, and regulating the mill spacing is 5 μ m, slowly is added dropwise to the composition of the crude drug of an amount of dissolve with ethanol continuously, behind the immersion 6h, at 4 ℃ of following cold preservation 24h Celsius, evacuation; At 40 ℃ of following vacuum dryings Celsius, with a spot of water and washing with alcohol 3 times, carry out drying with 40 ℃ of return air, obtain clathrate; The remove enclose method adopts methylene chloride reflux to extract 30min; Confirm through check, each crude drug is mixed in proportion, add dressing 8-10 part, surfactant 3-6 part, stirring is mixed with nanometer medicine slurry; In nanometer medicine slurry, add Percutaneous absorption enhancer 0.3-0.5 part and gel matrix 3-5 part, send into spiral fashion so cold drying coating machine after stirring, be coated on cloth or non-woven fabrics or polyethylene sheets; Coating back drying, sterilization, sterilization, shearing, quality inspection, the finished product packing warehouse-in.
3, the Chinese herbs paste and the manufacture method of treatment flu according to claim 2 and pain is characterized in that dressing is Kaolin, bentonite, zinc oxide, titanium dioxide, adopts more than one at least; Promoter is methyl salicylate, Camphora, Mentholum, adopts more than one at least; Gel matrix is pressure sensitive adhesive, resin glue, rubber, adopts more than one at least.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810151803A CN101683510A (en) | 2008-09-26 | 2008-09-26 | Chinese medicine patch for treating cold and pain and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810151803A CN101683510A (en) | 2008-09-26 | 2008-09-26 | Chinese medicine patch for treating cold and pain and method for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101683510A true CN101683510A (en) | 2010-03-31 |
Family
ID=42047039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810151803A Withdrawn CN101683510A (en) | 2008-09-26 | 2008-09-26 | Chinese medicine patch for treating cold and pain and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101683510A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889736A (en) * | 2010-07-08 | 2010-11-24 | 浙江神力针织品有限公司 | Chinese medicinal health-care sock and production method thereof |
| WO2012026829A1 (en) * | 2010-08-27 | 2012-03-01 | Rato Health Limited | Transdermal patch |
| DE102014113770A1 (en) * | 2014-09-23 | 2016-03-24 | Msf Medizinische Sportwerke Frankfurt Gmbh | Plaster with oily plant extracts |
-
2008
- 2008-09-26 CN CN200810151803A patent/CN101683510A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889736A (en) * | 2010-07-08 | 2010-11-24 | 浙江神力针织品有限公司 | Chinese medicinal health-care sock and production method thereof |
| WO2012026829A1 (en) * | 2010-08-27 | 2012-03-01 | Rato Health Limited | Transdermal patch |
| DE102014113770A1 (en) * | 2014-09-23 | 2016-03-24 | Msf Medizinische Sportwerke Frankfurt Gmbh | Plaster with oily plant extracts |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102961282A (en) | Composition with penetration enhancing effect as well as preparation method and application thereof | |
| CN102068494B (en) | Health-care capsules with treatment effect on chemical liver injury and preparation method thereof | |
| CN101683510A (en) | Chinese medicine patch for treating cold and pain and method for producing the same | |
| CN100435801C (en) | External use medicine for treating dermatosis and its preparing method | |
| CN101683394A (en) | Externally applied patch for treating phlebitis and method for producing the same | |
| CN101683375A (en) | Chinese medicine patch for treating rheumatism and impediment pain and method for producing the same | |
| CN102335132A (en) | Asarin inhalation aerosol and preparation method thereof | |
| TWI605821B (en) | A use of an extract of asplenium australasicum (j. sm.) hook. | |
| CN1552308A (en) | Nano spectrum endermatic medicinal paste and its preparation | |
| CN102940777A (en) | Cough relieving and sore-throat relieving cataplasm and preparation method thereof | |
| CN101683372A (en) | Chinese medicine patch with anti-inflammation and delactation functions and method for producing the same | |
| CN103705561A (en) | American ginseng berry pharmaceutical composition and preparation method and application thereof | |
| CN101683376A (en) | Patch for treating toothache and method for producing the same | |
| CN1985884A (en) | Sunstroke treating plaster and its preparing method | |
| CN101683388A (en) | Patch applied on navel for treating enuresis of children and method for producing the same | |
| CN101683492A (en) | Patch for treating facioplegia and method for producing the same | |
| CN101468140A (en) | Gel patch for treating cardiopalmus and method for preparing the same | |
| CN109528708A (en) | Application of the Kaempferol in preparation treatment rhinitis drug | |
| CN107485484A (en) | Suitable for general sexual trauma, the wound of chronic trauma patch | |
| CN101683412A (en) | Chinese medicine patch for treating children's bronchus asthma and method for producing the same | |
| CN101601716A (en) | The patch of treatment chronic bronchitis | |
| CN1985910A (en) | Plaster for treating constipation and its preparing method | |
| CN103381222A (en) | Plant radix-tetrastigmae gaseous preparation and preparation method | |
| CN107496670A (en) | A kind of preparation method of Fritillaria unibracteata superfine powder | |
| CN106166180A (en) | A kind of Chinese medicine composition treating oral ulcer and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C04 | Withdrawal of patent application after publication (patent law 2001) | ||
| WW01 | Invention patent application withdrawn after publication |
Open date: 20100331 |