CN103705561A - American ginseng berry pharmaceutical composition and preparation method and application thereof - Google Patents
American ginseng berry pharmaceutical composition and preparation method and application thereof Download PDFInfo
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- CN103705561A CN103705561A CN201410001179.2A CN201410001179A CN103705561A CN 103705561 A CN103705561 A CN 103705561A CN 201410001179 A CN201410001179 A CN 201410001179A CN 103705561 A CN103705561 A CN 103705561A
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- 240000005373 Panax quinquefolius Species 0.000 title claims abstract description 43
- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 43
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 235000021028 berry Nutrition 0.000 title abstract 6
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000002552 dosage form Substances 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 3
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 37
- 239000000284 extract Substances 0.000 claims description 19
- 241000628997 Flos Species 0.000 claims description 17
- 229920001282 polysaccharide Polymers 0.000 claims description 17
- 150000004676 glycans Chemical class 0.000 claims description 16
- 239000005017 polysaccharide Substances 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 235000021022 fresh fruits Nutrition 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000003809 water extraction Methods 0.000 claims description 8
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 230000000274 adsorptive effect Effects 0.000 claims description 4
- 230000008030 elimination Effects 0.000 claims description 4
- 238000003379 elimination reaction Methods 0.000 claims description 4
- 238000002386 leaching Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000003480 eluent Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 8
- 239000000470 constituent Substances 0.000 abstract description 3
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract description 2
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract 1
- 201000009240 nasopharyngitis Diseases 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 description 12
- 230000036039 immunity Effects 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000002155 anti-virotic effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
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- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- 235000013311 vegetables Nutrition 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an American ginseng berry pharmaceutical composition. The American ginseng berry pharmaceutical composition is prepared from extracting solutions of the following raw materials in parts by weight: 100 parts of fresh American ginseng berry and 0.1-5 parts of wild chrysanthemum flower. The invention also provides a preparation method of the American ginseng berry pharmaceutical composition. The method comprises the steps of mixing the extracting solutions in proportion and drying to prepare various required dosage forms. The American ginseng berry pharmaceutical composition can be used for preparing medicaments for preventing and treating common colds, in particular to flu; the pharmaceutical composition has high content of effective constituents, can be used for preventing the flu in a prone period when being taken in an electuary manner, and can accelerate to improve the cold by combination with other medicaments for treating the cold.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of american ginseng fruit Pharmaceutical composition and preparation method and purposes.
Background technology
Flu is a kind of disease the most occurred frequently in people's daily life, mainly due to body immunity, declines, and causes antibacterial, virus to be had an opportunity to take advantage of, due to infecting.It follows disease as symptoms such as headache, heating, cough, nasal obstruction, rhinorrhea.Especially influenza, more often sends out in the city that population density is large.Social allegro life now, flu has had a strong impact on people's production and life.Preventing cold is generally started with from two aspects, and the one, improve autoimmunity, resist virus, such as, note taking exercise the food of feed enhancing immunity etc. more; On the other hand, with medicine blocking virus, infect normal structure, cell, weaken its infection ability.
Some vegetable polysaccharidess are proved to be has anti-virus ability.Its antiviral-mechanism is mainly, and directly suppresses viral attached cell, enters cell; Be exactly by regulating body immune system, strengthening antiviral immunity reaction etc. more in addition.
Radix Panacis Quinquefolii, is Araliaceae, latin name Panaxquinquefolium.In its fruit, be rich in polysaccharide, main component is that polysaccharide is the macromolecular compound that one or more more than molecule monosaccharide are formed by connecting by ten.Research shows, it has gratifying immunological enhancement to body.And can play stimulation to mouse spleen lymphocyte differentiation, thereby enhancing human body immunity power.In addition, its anti-virus ability is mainly to hinder virus adhere to and infect normal cell tissue, and has the effect that reduces concurrent rear tissue injury.
Flos Chrysanthemi Indici, feverfew, latin name Chrysanthemum indicum.Experimental studies results shows, its water extract has well antibacterial and antiviral activity.
Yet although the Chinese medicine side effect of these integration of edible and medicinal herbs is little, general active constituent content is low, thereby dose is large, takes inconvenience, and combination and the difficult grasp of proportioning.If can process with modern crafts, extract concentrated its effective ingredient, according to proper ratio collocation, and make the dosage forms such as electuary of easily taking, can greatly facilitate now city crowd to improving immunity of organisms, antiviral, prevention and treat the demand of influenza.
Summary of the invention
The object of this invention is to provide Pharmaceutical composition a kind of novelty, that contain american ginseng fruit polysaccharide and preparation method thereof, Pharmaceutical composition is in prevention and treatment flu, the application in especially grippal medicine and health product.
Technical scheme of the present invention is achieved in that a kind of american ginseng fruit Pharmaceutical composition, mainly by the extracting solution of following weight meter raw material, is made: 100 parts, american ginseng fruit fresh fruit, Flos Chrysanthemi Indici 0.1-5 part.
Described american ginseng fruit fresh fruit is ripe Fructus Panacis Quinquefolii fresh fruit.
Described Pharmaceutical composition is tablet, powder, oral liquid, oral latex emulsion, capsule, suspension, granule or electuary, and preferred dosage form is powder or oral liquid.For powder, without adding excipient; For oral liquid, described excipient can be distilled water.
For mouthfeel, in compositions extract, also add Mel 0.05-2 part.Can further add as required the additives such as correctives, sweeting agent, antiseptic or emulsifying agent.
The present invention also provides the preparation method of american ginseng fruit Pharmaceutical composition, and its step is as follows:
A, american ginseng fruit polysaccharide extract: american ginseng fruit fresh fruit is broken except son, drink water extraction 2 h for 95 ℃, repeat to extract 1 time, auxiliary with intermittent ultrasonic waves in leaching process, extracting solution adds edible ethanol to final concentration 50%, upper D4020 macroporous adsorptive resins, and effluent is american ginseng fruit polysaccharide extraction liquid, 50% concentration of alcohol had both retained most polysaccharide, had removed again the ginsenoside of easy generation individual variation;
B, Flos Chrysanthemi Indici extract: Flos Chrysanthemi Indici (for meeting the crude drug of 2010 editions requirements of < < Chinese Pharmacopoeia > >), drink water extraction 2 h for 95 ℃, repeat to extract 1 time, supernatant is Flos Chrysanthemi Indici water extract;
C, combination drying: 100 L american ginseng fruit polysaccharide extraction liquids are mixed with 10 L Flos Chrysanthemi Indici water extracts, add Mel, after mix homogeneously, elimination insoluble matter, distilling under reduced pressure to 40～50 L, spraying is dry;
D, preparation: make described dosage form.
Described intermittent ultrasonic waves is auxiliary, its ultrasonic 1 min interval 3 min, and power is 300-500 W, it is preferably 400W.
In described extraction process, resin column continues the edible ethanol eluting with 68-70%, stays eluent.
American ginseng fruit Pharmaceutical composition of the present invention application in prevention and treatment flu, especially grippal prevention and treatment.
Beneficial effect of the present invention is: Pharmaceutical composition of the present invention can be used for preparation prevention and treatment flu, the especially medicine of influenza.Described pharmaceutical composition active constituent content is high, influenza prone period, with electuary form, takes and can effectively prevent and treat influenza.With the drug combination for the treatment of flu, can accelerate the improvement of flu.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further explained to explanation.
embodiment 1one embodiment of the invention are that described Pharmaceutical composition is electuary, and this electuary has following composition: 100 kilograms, american ginseng fruit fresh fruit, 0.5 kilogram of Flos Chrysanthemi Indici, 0.1 kilogram of Mel.Its preparation method is:
A, american ginseng fruit polysaccharide extract: 100 kilograms, american ginseng fruit fresh fruit, broken except son, with 25 L drinking waters, 95 ℃ of water extraction 2 h, repeat to extract 1 time, auxiliary with intermittent ultrasonic waves in leaching process.Extracting solution adds edible ethanol to final concentration 50%, upper D4020 macroporous adsorptive resins, and effluent is american ginseng fruit polysaccharide extraction liquid 100 L;
B, Flos Chrysanthemi Indici extract: 0.5 kilogram of Flos Chrysanthemi Indici, and with 5 L drinking waters, 95 ℃ of water extraction 2 h, repeat to extract 1 time, and supernatant is Flos Chrysanthemi Indici water extract 10 L;
C, mix, dry: 100 L american ginseng fruit polysaccharide extraction liquids are mixed with 10 L Flos Chrysanthemi Indici water extracts, add 0.1 kilogram of Mel, after mix homogeneously, elimination insoluble matter, distilling under reduced pressure to 40～50 L, sprays and is dried.
D, packing: by dried granule packaging, both obtained electuary.
embodiment 2another embodiment of the invention is that described Pharmaceutical composition is oral liquid, and this oral liquid has following composition: 100 kilograms, american ginseng fruit fresh fruit, 1 kilogram of Flos Chrysanthemi Indici, 0.3 kilogram of Mel.Its preparation method is:
A, american ginseng fruit polysaccharide extract: 100 kilograms, american ginseng fruit fresh fruit, broken except son, with 25 L drinking waters, 95 ℃ of water extraction 2 h, repeat to extract 1 time, auxiliary with intermittent ultrasonic waves in leaching process.Extracting solution adds edible ethanol to final concentration 50%, upper D4020 macroporous adsorptive resins, and effluent is american ginseng fruit polysaccharide extraction liquid 100 L;
B, Flos Chrysanthemi Indici extract: 1 kilogram of Flos Chrysanthemi Indici, and with 5 L drinking waters, 95 ℃ of water extraction 2 h, repeat to extract 1 time, and supernatant is Flos Chrysanthemi Indici water extract 10 L;
C, mix, dry: 100 L american ginseng fruit polysaccharide extraction liquids are mixed with 10 L Flos Chrysanthemi Indici water extracts, add 0.3 kilogram of Mel, elimination insoluble matter after mix homogeneously, both must oral liquid.
The above; it is only the preferably specific embodiment of the present invention; but protection scope of the present invention is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; according to technical scheme of the present invention and inventive concept thereof, be equal to replacement or changed, within all should being encompassed in protection scope of the present invention.
Claims (8)
1. an american ginseng fruit Pharmaceutical composition, is characterized in that, mainly by the extracting solution of following weight meter raw material, is made: 100 parts, american ginseng fruit fresh fruit, Flos Chrysanthemi Indici 0.1-5 part.
2. american ginseng fruit Pharmaceutical composition according to claim 1, is characterized in that, described american ginseng fruit fresh fruit is ripe Fructus Panacis Quinquefolii fresh fruit.
3. american ginseng fruit Pharmaceutical composition according to claim 1, is characterized in that, Pharmaceutical composition is tablet, powder, oral liquid, oral latex emulsion, capsule, suspension, granule or electuary.
4. according to the american ginseng fruit Pharmaceutical composition described in claim 1-3 any one, it is characterized in that, also contain Mel 0.05-2 part.
5. the preparation method of american ginseng fruit Pharmaceutical composition as claimed in claim 4, is characterized in that, step is as follows:
A, american ginseng fruit polysaccharide extract: american ginseng fruit fresh fruit is broken drinks water extraction 2 h for 95 ℃ except son, repeats to extract 1 time, auxiliary with intermittent ultrasonic waves in leaching process, extracting solution adds edible ethanol to final concentration 50%, upper D4020 macroporous adsorptive resins, and effluent is american ginseng fruit polysaccharide extraction liquid;
B, Flos Chrysanthemi Indici extract: Flos Chrysanthemi Indici, drink water extraction 2 h for 95 ℃, and repeat to extract 1 time, supernatant is Flos Chrysanthemi Indici water extract;
C, combination drying: 100 L american ginseng fruit polysaccharide extraction liquids are mixed with 10 L Flos Chrysanthemi Indici water extracts, add Mel, after mix homogeneously, elimination insoluble matter, distilling under reduced pressure to 40～50 L, spraying is dry;
D, preparation: make described dosage form.
6. the preparation method of american ginseng fruit Pharmaceutical composition according to claim 5, is characterized in that, described intermittent ultrasonic waves is auxiliary, its ultrasonic 1 min interval 3 min, and power is 300-500 W.
7. the preparation method of american ginseng fruit Pharmaceutical composition according to claim 5, is characterized in that, in described extraction process, resin column continues the edible ethanol eluting with 68-70%, stays eluent.
8. an american ginseng fruit Pharmaceutical composition is preventing and is treating the application in flu.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410001179.2A CN103705561A (en) | 2014-01-03 | 2014-01-03 | American ginseng berry pharmaceutical composition and preparation method and application thereof |
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| CN201410001179.2A CN103705561A (en) | 2014-01-03 | 2014-01-03 | American ginseng berry pharmaceutical composition and preparation method and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523958A (en) * | 2014-12-18 | 2015-04-22 | 高红煜 | Compound American ginseng sublingual tablet and preparation method thereof |
| WO2019212203A1 (en) * | 2018-05-02 | 2019-11-07 | ㈜아모레퍼시픽 | Composition for preventing or inhibiting influenza virus infection, containing ginseng berry polysaccharides |
| CN112368008A (en) * | 2018-05-02 | 2021-02-12 | 株式会社爱茉莉太平洋 | Composition for preventing or inhibiting influenza virus infection comprising ginseng fruit polysaccharide |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1611254A (en) * | 2003-10-27 | 2005-05-04 | 吉林省集安益盛药业股份有限公司 | American ginseng fruit, and its medicinal composition and pharmaceutical use |
| CN1724040A (en) * | 2005-07-14 | 2006-01-25 | 陕西容厦药业股份有限公司 | Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method |
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2014
- 2014-01-03 CN CN201410001179.2A patent/CN103705561A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1611254A (en) * | 2003-10-27 | 2005-05-04 | 吉林省集安益盛药业股份有限公司 | American ginseng fruit, and its medicinal composition and pharmaceutical use |
| CN1724040A (en) * | 2005-07-14 | 2006-01-25 | 陕西容厦药业股份有限公司 | Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method |
Non-Patent Citations (2)
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| 华海清: "野菊花临床应用研究概况", 《湖南中医药导报》, vol. 1, no. 01, 31 October 1994 (1994-10-31) * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523958A (en) * | 2014-12-18 | 2015-04-22 | 高红煜 | Compound American ginseng sublingual tablet and preparation method thereof |
| WO2019212203A1 (en) * | 2018-05-02 | 2019-11-07 | ㈜아모레퍼시픽 | Composition for preventing or inhibiting influenza virus infection, containing ginseng berry polysaccharides |
| CN112368008A (en) * | 2018-05-02 | 2021-02-12 | 株式会社爱茉莉太平洋 | Composition for preventing or inhibiting influenza virus infection comprising ginseng fruit polysaccharide |
| US20210196776A1 (en) * | 2018-05-02 | 2021-07-01 | Amorepacific Corporation | Composition for preventing or inhibiting influenza virus infection, containing ginseng berry polysaccharides |
| JP2021521868A (en) * | 2018-05-02 | 2021-08-30 | アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ | Composition for prevention or suppression of influenza virus infection containing ginseng fruit polysaccharide |
| EP3811957A4 (en) * | 2018-05-02 | 2022-03-02 | Amorepacific Corporation | Composition for preventing or inhibiting influenza virus infection, containing ginseng berry polysaccharides |
| CN112368008B (en) * | 2018-05-02 | 2022-11-29 | 株式会社爱茉莉太平洋 | Composition for preventing or inhibiting influenza virus infection comprising ginseng fruit polysaccharide |
| US11642387B2 (en) * | 2018-05-02 | 2023-05-09 | Amorepacific Corporation | Composition for preventing or inhibiting influenza virus infection, containing ginseng berry polysaccharides |
| JP7273065B2 (en) | 2018-05-02 | 2023-05-12 | アモーレパシフィック コーポレーション | Composition for preventing or suppressing influenza virus infection containing ginseng nut polysaccharide |
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Effective date of registration: 20151209 Address after: 264200, Weihai District, Shandong City, Huancui Province sheep town project two district Applicant after: WEIHAI NUTRAWAY PHARMACEUTICALS CO., LTD. Address before: 116023 No. 457, Shahekou, Dalian District, Liaoning, Zhongshan Road Applicant before: Liu Yang |
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| CB02 | Change of applicant information |
Address after: 264200, Weihai District, Shandong City, Huancui Province sheep town project two district Applicant after: WEIHAI SONGLING NUOKEJIA CHINESE HERBAL MEDICINE CO., LTD. Address before: 264200, Weihai District, Shandong City, Huancui Province sheep town project two district Applicant before: WEIHAI NUTRAWAY PHARMACEUTICALS CO., LTD. |
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Application publication date: 20140409 |