CN103006922A - Composition having function of relieving alcoholism to protect liver - Google Patents
Composition having function of relieving alcoholism to protect liver Download PDFInfo
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- CN103006922A CN103006922A CN2012105698665A CN201210569866A CN103006922A CN 103006922 A CN103006922 A CN 103006922A CN 2012105698665 A CN2012105698665 A CN 2012105698665A CN 201210569866 A CN201210569866 A CN 201210569866A CN 103006922 A CN103006922 A CN 103006922A
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Abstract
The invention relates to a composition having a function of relieving alcoholism to protect liver. The composition is composed of the following components of, by weight, 10-90 parts of vine tea and 10-90 parts of blueberry. A preparation method mainly comprises the following steps of (1) mixing vine tea and blueberry according to a prescription proportion, extracting by using a water decoction extraction method, an ultrasonic extraction method or an ethanol refluxing extraction method to obtain an extract; and (2) adding conventional auxiliary materials to the extract obtained from the step (1) and mixing according to a conventional method to obtain a needed health-care product. The composition can enhance tolerance of a human body to alcohol, prevent acute alcohol alcoholism and assist to treat alcoholic liver damage and alcoholic allergy. The composition is stable in quality, easy to carry, convenient for use, small is dosage and rapid in curative effect.
Description
Technical field
The present invention relates to a kind of compositions with sobering up and liver protecting functions, belong to health product technology field.
Background technology
Can occur in a short time dizziness headache after the people drinks, feel sick, vomit, blush, irritated, palpitate quickly, the untoward reaction such as hypertension, inappetence, fatigue and weak.Relieving the effect of alcohol refers to alleviate because that the untoward reaction of drinking causes is nervous, improves people's lucidity and respond.The principle of relieving the effect of alcohol refers to increase human body to the tolerance degree of ethanol, postpone ataxia phase and lethargic stage, and shorten the lethargic stage that causes owing to excessive consumption of alcohol, by suppressing the ethanol absorption and improving the alcohol dehydrogenase enzyme activity, effectively reduce ethanol content in the blood, the content of the harmful substances such as ethanol in the rear body, acetaldehyde of drinking with minimizing.Hepatoprotective refers to remove free radical, to reach liver-protective purpose by improving the vigor of catalase, glutathione transferase, superoxide dismutase.
China is drinks productive consumption big country, and the inebriant of annual consumption reaches more than 2,000 ten thousand tons, is addicted to drink or the alcohol dependence crowd reaches about 200,000,000, and acute and chronic alcoholism rate increases day by day.Acute alcoholism is commonly called as drunk, the loss process that drink enters the central nervous system that causes after excessive ethanol or the alcoholic beverage, digestive system, respiratory system, cardio-cerebrovascular etc., show as lose one's temper, disturbance of consciousness, respiration inhibition even dead etc.The fatty liver that chronic alcoholism causes, liver cirrhosis, onset of liver cancer rate rise year by year, are one of main inducing of China people hepatic injury.Therefore, according to Chinese physique characteristic, in conjunction with the alcoholism principle, the relieving alcoholism and protecting the liver mechanism of medicine is studied, developed a kind of effective relieving alcoholism and protecting the liver product extremely urgent.
Alcoholism mainly is disorderly to be caused by the main component ethanol in the wine and metabolism wadding thereof.Liver is the main place of alcohol metabolism.After ethanol enters liver, at first generate acetaldehyde by ethanol dehydrogenase (ADH) metabolism, acetaldehyde becomes acetic acid by aldehyde dehydrogenase (ALDH) metabolism then, is decomposed at last carbon dioxide and water.In the metabolic process of acetaldehyde, ALDH plays a part very important, but has the ALDH that only has of Oxidation in human body
1And ALDH
2Two kinds of isozymes, wherein ALDH
2It is the strongest a kind of isozyme of physiologically active among the ALDH.According to data, 50% Chinese lack ALDH
2, very easily cause acetaldehyde concentration to increase after drinking and accumulate, make that liver cell membrane antigen changes, the hepatocyte metabolism disorder, produce free radical and lipid peroxide etc.Therefore, can not produce normal aldehyde dehydrogenase in the body, be to cause the easily one of the main reasons of becoming impatient property alcoholism and alcoholic liver disease of Chinese.
Health product with sobering up and liver protecting functions of the prior art, mostly complicated component.For example, the functional health beverage that the disclosed a kind of help of CN1454526A is relieved the effect of alcohol, mainly be adopt Ampelopsis grossedentata, Fructus Citri Sarcodactylis, orange, Radix Puerariae, components such as adding taurine, concentrated orange juice, Fructus Citri Limoniae juice and Mel are refining to be formed Radix Glycyrrhizae through extracting.Contain Ampelopsis grossedentata and other components more than eight kinds in this scheme, increased cost and uncontrollable composition of disintoxicating product, the effect of relieving the effect of alcohol is not ideal enough.
Summary of the invention
The invention provides a kind of compositions with Antialcoholic liver-protecting effect, another object of the present invention provides this application of compositions in the health product of preparation Antialcoholic liver-protecting with Antialcoholic liver-protecting function.It can strengthen the people to the metabolic capacity of ethanol, and the after drinking emotion of people of releiving improves respond, and removes free radical, auxiliary treatment and preventing alcoholic liver injury.
Compositions of the present invention is made by the medicine of following weight portion: 10～90 parts of Ampelopsis grossedentata, 10～90 parts of blue berries.
Particularly, the present invention is made by the medicine of following weight portion: 30～70 parts of Ampelopsis grossedentata, 30～70 parts of blue berries.
Further, the raw materials used parts by weight of the present invention can be adopted as: 50 parts of Ampelopsis grossedentata, 50 parts of blue berries.
In the compositions with sobering up and liver protecting functions of the present invention, Ampelopsis grossedentata and blue berry are integration of edible and medicinal herbs Chinese medicine, and Ampelopsis grossedentata contains a large amount of dihydromyricetin, contains the splendid anthocyanidin of antioxidant effect in the blue berry.The sweet length of Ampelopsis grossedentata mildly bitter flavor, cool in nature, but promoting the production of body fluid to quench thirst has the effects such as heat-clearing and toxic substances removing, anti-inflammation, expelling wind and removing dampness, bone and muscle strengthening, blood pressure lowering, blood fat reducing, hepatoprotective.After the compositions of Ampelopsis grossedentata and blue berry enters human body, can significantly improve alcohol dehydrogenase activity, and activate the catalase path, and make body in the situation that the aldehyde dehydrogenase disappearance can be acetic acid with alcohol metabolism quickly and effectively also, be a kind of antialcoholic drug of suitable Chinese's body constitution therefore.In addition, nervus centralis be refreshed oneself, be protected to compositions of the present invention can also calmness; The protection nervus centralis prerequisite under, compositions can improve the people after drinking respond, releive the people after drinking emotion, alleviate sleepiness.Compared to calm class medicine, more be of value to health.
Another purpose of the present invention provides the related manufacturing processes of this compositions and preparation thereof.
The preparation method of the present composition mainly may further comprise the steps:
(1) gets Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, adopt the method for water boiling and extraction, supersound extraction or alcohol reflux to obtain extract;
(2) with the extract of gained in the step (1) according to conventional method, add conventional adjuvant, be mixed and made into required health product.
Particularly, the preparation method of the present composition mainly may further comprise the steps:
(1) get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add 6-10 times of water boiling and extraction 1-2h, filter, filtering residue adds 2-5 times of water boiling and extraction 3-5h, filters, and merging filtrate obtains extract; Or add 6-10 times of water supersound extraction 2-4 time, and each 20-40 minute, filter, merging filtrate obtains extract; Or add the 5-10 times of ethanol that concentration is 50%-95%, and reflux, extract, 1-3 time, each 1-2 hour, filter, merging filtrate obtains extract;
(2) with the extract of gained in the step (1) according to conventional method, add conventional adjuvant, be mixed and made into required health product.
The dosage form of health product of the present invention can be capsule, tablet, granule, medicinal tea, oral liquid, compound vinegar or beverage.Be preferably capsule.
Wherein, the preparation method of capsule is: get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add the 5-10 times of ethanol that concentration is 50%-95%, reflux, extract, 1-3 time, each 1-2 hour, filter merging filtrate, the concentrated extractum that obtains, add 60-70 part dextrin, dry, pulverizing obtains extract powder, adds 1.3-2 part alanine, 2.2-2.8 part glutamine, mixing again, incapsulate, namely get capsule.
The preparation method of capsule can also for: get Ampelopsis grossedentata, blue berry, pulverize, cross 40 mesh sieves, after the mixing of prescription ratio, add 6-10 times of water supersound extraction 2-4 time, each 20-40 minute, filter, merging filtrate, filtrate boils off solution with Rotary Evaporators, gets brownish black extractum, extractum is spray dried to powder, cross the 100-120 mesh sieve, encapsulated, namely get capsule.
The preparation method of compound vinegar is: get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add 6-10 times of water boiling and extraction 1-2h, filter, filtering residue adds 2-5 times of water boiling and extraction 3-5h, filter, and merging filtrate, adjusting the crude drug amount is 100-200g/L; Add clarifier, leave standstill 10-12h, filter; Filtrate adds 1.3-2 part alanine, 2.2-2.8 part glutamine, stirs; The gained mixed liquor adds rice vinegar, sucrose, makes compound vinegar.
The preparation method of beverage is: get Ampelopsis grossedentata, blue berry in the prescription ratio, add 6-10 times of water, decoct and extract 1-2h, filter, get filtering residue and add again 2-5 times of water, decoct and extract 3-5h, filter, merging filtrate, regulating the crude drug amount is 100～200g/L, adding sucrose behind the mixing, to make sugar content be 30%-35%, namely gets beverage.
Beneficial effect of the present invention: can improve human body to the tolerance of ethanol, prophylaxis of acute alcoholism, auxiliary treatment alcoholic liver injury and ethanol are irritated; Quality is more stable, carries, easy to use, and dose is little, and curative effect is rapid.
For the ease of understanding the present invention at the medical value aspect the relieving alcoholism and protecting the liver, below the pharmacological experiment of employing medicine of the present invention is further set forth the beneficial effect of medicine of the present invention.
Experimental example 1: the ethanol acute toxicity is learned research
1.1 laboratory animal and grouping
The NIH mice, male and female half and half, the cleaning grade standard by the ordering of body weight size, is selected the healthy animal of body weight 18 ~ 22g, random packet, 10 every group.If blank group, ethanol matched group and the basic, normal, high Three doses of water boiling and extraction thing A() etc. experimental group.
Wherein, the preparation method of water boiling and extraction thing A is: get recipe quantity Ampelopsis grossedentata, blue berry, add 6-10 times of water boiling and extraction 1-2h after mixing, filter, filtering residue adds 2-5 times of water boiling and extraction 3-5h, filters, and merging filtrate obtains extract A.
1.2 laboratory sample
(1) solution of extract A: be equivalent to crude drug content 0.35g/ml, dosage is equivalent to crude drug 3.5g/kg body weight.
(2) normal saline (sodium chloride injection), NaCl content 0.9%.
(3) 99.7% ethanol (analytical pure, Long March chemical plant, Hangzhou, lot number: 20100302)
1.3 instrument and reagent
Operating scissors, ophthalmic tweezers, syringe, pallet, animal operating table, centrifuge, ethanol, normal saline.
1.4 experimental technique and result:
1.4.1 the median lethal dose(LD 50) (LD of ethanol
50).
Get 5 groups of mices, 10 every group, carry out gavage for every group of mice with the ethanol of various dose, and calculate its median lethal dose(LD 50).The results are shown in Table 1.
The acute toxicity of table 1 Mice Hepatocytes Injured by Ethanol
| Ethanol dosage (g/kg) | Number of animals | Death toll | Mortality rate (%) |
| 12.46 | 10 | 10 | 100 |
| 11.23 | 10 | 8 | 80 |
| 10.0 | 10 | 5 | 50 |
| 9.0 | 10 | 1 | 10 |
| 8.0 | 10 | 0 | 0 |
According to table 1 data and LD
50Computing method, calculate the median lethal dose(LD 50) (LD of chronic ethanol treated mice
50) be 10.11g/kg.
1.4.2 the prophylactic tria research to acute ethanol toxicity
Get 5 groups of mices, every group 10, be respectively: normal saline group, ethanol group, the basic, normal, high dosage group of sample extraction thing A, every group of basic, normal, high dosage (being equivalent to crude drug amount 50,100,200mg/ml) that injects extract A when giving median lethal dose(LD 50) ethanol to according to the form below dosage.Experimental result sees Table 2:
The preventive effect that table 2 product is poisoned to acute ethanol
| Group | Dosage (mg/ml) | Number of animals | Death toll | Mortality rate (%) |
| The normal saline group | - | 10 | 0 | 0 |
| The ethanol group | - | 10 | 6 | 60 |
| The A low dose group | 50 | 10 | 5 | 50 |
| Dosage group among the A | 100 | 10 | 3 | 30 |
| The A high dose group | 200 | 10 | 2 | 20 |
The experimental result demonstration, the present composition has the acute ethanol toxic action of prevention mice, can reduce the mortality rate of mice, has sobering-up functions; The extract A high dose group obviously brings up to 20% by 60% mortality rate of ethanol matched group, has obviously strengthened the toleration of mice to acute ethanol toxicity.
Experimental example 2: different dosing dosage is to the research of ethanol to hepatic injury
2.1 laboratory animal and grouping
The SD rat, male, body weight 180.0-220.0g, cleaning grade standard, totally 60.Be divided at random 6 groups, 10 every group.If blank, high, medium and low three dosage groups of positive control and extract of the present invention.
2.2 laboratory sample
Extract of the present invention: the method according to embodiment 3 or 4 is extracted, and then twice extract filtrate is condensed into extractum, and amounting to crude drug content is 350mg/ml.Positive thing adopts bifendate drop pill: 0.2g/kg.
2.3 experiment grouping
(1) high dose group: extract extractum dilution administration, be equivalent to crude drug content 200mg/ml, dosage is equivalent to crude drug 2000mg/kg body weight.
(2) dosage group in: the extract high dose group, add normal saline, press the rear administration of 1:2 dilution, be equivalent to crude drug content 100mg/ml, dosage is equivalent to crude drug 1000mg/kg body weight.
(3) low dose group: the extract high dose group, add normal saline, press the 1:4 dilution, administration after the dilution is equivalent to crude drug content 50mg/ml, and dosage is equivalent to crude drug 500mg/kg body weight.
2.4 experimental technique and result:
2.4.1 ethanol causes liver injury protection research
Each organizes once a day on request continuous lumbar injection (every 100g body weight administration 1mL) administration 10d positive controls and extract, and respectively at experiment the 5th day and the 9th day administration 1h pneumoretroperitoneum injection alcoholic solution (3mLkg
-1); Blank group and model group replace the test medication with 0.9% sodium chloride solution lumbar injection of equivalent, and model group is in experiment the 5th day and the 9th day administration 1h pneumoretroperitoneum injection alcoholic solution (3mLkg simultaneously
-1).Administration 4h posterior orbit was got blood 1mL, 3000rmin in the 10th day
-1Centrifugal 10min, separation of serum ,-20 ℃ of preservations.Be used for Serum ALT and AST.By statistics, each dosage group liver function experimental result sees Table 3:
Each dosage group Liver Function of table 3 relatively
Compare * * P＜0.01, * P＜0.05 with model group.
By as seen from Table 3, compare with normal group, ALT, AST are active in the model group rat blood serum significantly raises (P＜0.01), and the modeling of prompting chemical liver injury is successful.Compare the active significantly reduction of ALT, AST in the rat blood serum after each dosage group treatment of extract with model group.Wherein, effect and the positive controls of extracting object height, middle dosage group are suitable, illustrate that said preparation has significant protective effect to alcoholic liver injury.
3 discuss
By above-mentioned experimental result as can be known, the compositions with sobering up and liver protecting functions of the present invention can strengthen mice to the toleration of acute ethanol toxicity, significantly reduces ALT in the rat blood serum, AST active, therefore have well relieve the effect of alcohol, the hepatoprotective effect.
The specific embodiment
Further explain the present invention below in conjunction with embodiment, but content of the present invention is not limited to the following stated.
Embodiment 1
Prescription: Ampelopsis grossedentata 10kg, blue berry 90kg
Method for making: get Ampelopsis grossedentata, blue berry, pulverize, cross 20 mesh sieves, after pressing the recipe quantity mixing, add 6 times of water gagings and decoct extraction 1h, filter, filtering residue adds 2 times of water gagings and decocts extraction 3h, filters merging filtrate, obtain extract, in extract, add the correctives of 1% weight and the antiseptic of 0.5% weight, add the water pondage to 1000L, fully mixing, oral liquid is made in packing.The 100ml/ bottle.
Embodiment 2
Prescription: Ampelopsis grossedentata 90kg, blue berry 10kg
Method for making: get Ampelopsis grossedentata, blue berry, pulverize, cross 20 mesh sieves, after press recipe quantity and mixing, adds 10 times of water gagings and decoct and extract 2h, filter, filtering residue adds 5 times of water gagings and decocts extraction 5h, filtration, and merging filtrate, the filtrate evaporate to dryness gets brownish black extractum; Extractum adds the dextrin of 35% weight, and mixing adds 10% starch slurry an amount of again, granulates, and drying adds the lubricant of 0.4% weight, and tablet machine is pressed into tablet, sugar coating, and packing namely gets tablet.
Embodiment 3
Prescription: Ampelopsis grossedentata 50kg, blue berry 50kg
Method for making: get Ampelopsis grossedentata, blue berry, pulverize, cross 40 mesh sieves, after press recipe quantity and mixing, add 8 times of water gaging supersound extraction three times, each 30 minutes, filtration, merging filtrate, the filtrate Rotary Evaporators boils off solution, gets brownish black extractum; Extractum is spray dried to powder, crosses about 100 ~ 120 orders and sieve, incapsulate, namely get capsule.
Embodiment 4
Prescription: Ampelopsis grossedentata 70kg, blue berry 30kg
Method for making: get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add 5 times of concentration and be 95% ethanol, reflux, extract, 2h, filter, the concentrated extractum that obtains of filtrate adds the 60kg dextrin, and dry, pulverizing obtains extract powder, add again 2kg alanine, 2.2kg glutamine, mixing incapsulates, and namely gets capsule.
Embodiment 5
Prescription: Ampelopsis grossedentata 30kg, blue berry 70kg
Method for making: get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add 10 times of concentration and be 50% ethanol, reflux, extract, 3 times each 1 hour, is filtered, merging filtrate, the concentrated extractum that obtains adds the 70kg dextrin, and dry, pulverizing obtains extract powder, add again 1.3kg alanine, 2.8kg glutamine, mixing incapsulates, and namely gets capsule.
Embodiment 6
Prescription: Ampelopsis grossedentata 40kg, blue berry 60kg
Method for making: get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add 6 times of water gagings and decoct extraction 2h, filter, 2 times of water gagings of filtering residue adding decoct and extract 3h, filtration, and merging filtrate, adjusting the crude drug amount is 100g/L; Add clarifier, leave standstill 10-12h, filter; Filtrate adds 1.3 parts of alanine, 2.2 parts of glutamine, stirs; The gained mixed liquor adds rice vinegar, sucrose, makes compound vinegar.
Embodiment 7
Prescription: Ampelopsis grossedentata 30kg, blue berry 10kg
Method for making: get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add 10 times of water boiling and extraction 1h, filter, filtering residue adds 5 times of water boiling and extraction 4h, filters, and merging filtrate, adjusting the crude drug amount is 200g/L; Add clarifier, leave standstill 10-12h, filter; Filtrate adds 2 parts of alanine, 2.8 parts of glutamine, stirs; The gained mixed liquor adds rice vinegar, sucrose, makes compound vinegar.
Embodiment 8
Prescription: Ampelopsis grossedentata 70kg, blue berry 20kg
Method for making: get Ampelopsis grossedentata, blue berry in the prescription ratio, add 7 times of water gagings, decoct to extract 1h, filter, get filtering residue and add again 4 times of water gagings, decoct and extract 4h, filter, merging filtrate, regulating the crude drug amount is 100g/L, adding sucrose behind the mixing, to make sugar content be 30%, namely gets beverage.
Embodiment 9
Prescription: Ampelopsis grossedentata 10kg, blue berry 50kg
Method for making: get Ampelopsis grossedentata, blue berry in the prescription ratio, add 9 times of water, decoct to extract 2h, filter, get filtering residue and add again 3 times of water, decoct and extract 3h, filter, merging filtrate, regulating the crude drug amount is 200g/L, adding sucrose behind the mixing, to make sugar content be 35%, namely gets beverage.
Embodiment 10
Prescription: Ampelopsis grossedentata 30kg, blue berry 60kg
Method for making: get Ampelopsis grossedentata, blue berry in the prescription ratio, add 8 times of water gagings and decoct extraction 2h, filter, get filtering residue and add again 2 times of water, decoct and extract 4h, filter, merging filtrate, the concentrated extractum that obtains adds the 65kg dextrin, and dry, pulverizing obtains extract powder, add again 1.5kg alanine, 2.5kg glutamine, add behind the mixing 60% ethanol moistening, granulate, drying namely gets granule.
Embodiment 10
Prescription: Ampelopsis grossedentata 80kg, blue berry 20kg
Method for making: get Ampelopsis grossedentata, blue berry in the prescription ratio, pulverize, add 1.8kg alanine, 2.2kg glutamine after fully mixing, cross 40 mesh sieves behind the mixing, pack namely gets health tea.
Claims (10)
1. compositions with sobering up and liver protecting functions is characterized in that: mainly the raw material by following weight portion forms: Ampelopsis grossedentata 10-90 part, blue berry 10-90 part.
2. the compositions with sobering up and liver protecting functions according to claim 1, it is characterized in that: raw materials used parts by weight are: Ampelopsis grossedentata extrat 30-70 part, blue berry extract 30-70 part.
3. the compositions with sobering up and liver protecting functions according to claim 1, it is characterized in that: raw materials used parts by weight are: 50 parts of Ampelopsis grossedentata extrats, 50 parts of blue berry extracts.
4. arbitrary described compositions with sobering up and liver protecting functions according to claim 1-3, it is characterized in that: preparation method mainly may further comprise the steps:
(1) gets Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, adopt the method for water boiling and extraction, supersound extraction or alcohol reflux to obtain extract;
(2) with the extract of gained in the step (1) according to conventional method, add conventional adjuvant, be mixed and made into required health product.
5. the compositions with sobering up and liver protecting functions according to claim 4, it is characterized in that: preparation method mainly may further comprise the steps:
(1) get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add 6-10 times of water boiling and extraction 1-2h, filter, filtering residue adds 2-5 times of water boiling and extraction 3-5h, filters, and merging filtrate obtains extract; Or add 6-10 times of water supersound extraction 2-4 time, and each 20-40 minute, filter, merging filtrate obtains extract; Or add the 5-10 times of ethanol that concentration is 50%-95%, and reflux, extract, 1-3 time, each 1-2 hour, filter, merging filtrate obtains extract;
(2) with the extract of gained in the step (1) according to conventional method, add conventional adjuvant, be mixed and made into required health product.
6. according to claim 4 or 5 described compositionss with sobering up and liver protecting functions, it is characterized in that: the dosage form of described health product can be capsule, tablet, granule, medicinal tea, oral liquid, compound vinegar or beverage.
7. the compositions with sobering up and liver protecting functions according to claim 6, it is characterized in that: the dosage form of described health product is capsule.
8. the compositions with sobering up and liver protecting functions according to claim 6, it is characterized in that: the preparation method of described capsule is: get Ampelopsis grossedentata, blue berry, after mixing in the prescription ratio, add the 5-10 times of ethanol that concentration is 50%-95%, reflux, extract, 1-3 time, each 1-2 hour, filter merging filtrate, the concentrated extractum that obtains, add 60-70 part dextrin, dry, pulverizing obtains extract powder, adds 1.3-2 part alanine, 2.2-2.8 part glutamine, mixing again, incapsulate, namely get capsule.
9. the compositions with sobering up and liver protecting functions according to claim 6, it is characterized in that: the preparation method of described compound vinegar is: get Ampelopsis grossedentata, blue berry, after the mixing of prescription ratio, add 6-10 times of water boiling and extraction 1-2h, filter, filtering residue adds 2-5 times of water boiling and extraction 3-5h, filters, merging filtrate, adjusting the crude drug amount is 100-200g/L; Add clarifier, leave standstill 10-12h, filter; Filtrate adds 1.3-2 part alanine, 2.2-2.8 part glutamine, stirs; The gained mixed liquor adds rice vinegar, sucrose, makes compound vinegar.
10. the compositions with sobering up and liver protecting functions according to claim 6, it is characterized in that: the preparation method of described beverage is: get Ampelopsis grossedentata, blue berry in the prescription ratio, add 6-10 times of water, decoct and extract 1-2h, filter, get filtering residue and add again 2-5 times of water, decoct and extract 3-5h, filter, merging filtrate, regulating the crude drug amount is 100～200g/L, and adding sucrose behind the mixing, to make sugar content be 30%-35%, namely gets beverage.
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| CN105748744A (en) * | 2016-04-07 | 2016-07-13 | 贵州苏佰瑞生物科技有限公司 | Blueberry composition with efficacies of resisting bacteria, diminishing inflammation and helping digestion and preparation method and application of blueberry composition |
| CN106261362A (en) * | 2016-08-08 | 2017-01-04 | 南昌大学 | A kind of honeysuckle composition beverage with the liver protecting effect and preparation method |
| CN106942415A (en) * | 2017-03-22 | 2017-07-14 | 佛山市恒南医药科技有限公司 | It is a kind of suitable for rattan mother-in-law's tea solid beverage of alleviating hangover and inducing resuscitation and preparation method thereof |
| CN108114267A (en) * | 2017-12-30 | 2018-06-05 | 佛山科学技术学院 | A kind of Antrodia camphorata oral liquor for sobering from wine and preparation method thereof |
| CN112826876A (en) * | 2021-02-02 | 2021-05-25 | 刘洪涛 | Application of ampelopsis grossedentata aqueous extract in preparation of preparation for improving liver injury |
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| CN106261362A (en) * | 2016-08-08 | 2017-01-04 | 南昌大学 | A kind of honeysuckle composition beverage with the liver protecting effect and preparation method |
| CN106942415A (en) * | 2017-03-22 | 2017-07-14 | 佛山市恒南医药科技有限公司 | It is a kind of suitable for rattan mother-in-law's tea solid beverage of alleviating hangover and inducing resuscitation and preparation method thereof |
| CN108114267A (en) * | 2017-12-30 | 2018-06-05 | 佛山科学技术学院 | A kind of Antrodia camphorata oral liquor for sobering from wine and preparation method thereof |
| CN112826876A (en) * | 2021-02-02 | 2021-05-25 | 刘洪涛 | Application of ampelopsis grossedentata aqueous extract in preparation of preparation for improving liver injury |
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Application publication date: 20130403 |