CN108379500B - Wheat seedling traditional Chinese medicine composition for nourishing liver, dispelling effects of alcohol, sobering up and preventing halitosis and preparation method thereof - Google Patents

Wheat seedling traditional Chinese medicine composition for nourishing liver, dispelling effects of alcohol, sobering up and preventing halitosis and preparation method thereof Download PDF

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CN108379500B
CN108379500B CN201810421136.8A CN201810421136A CN108379500B CN 108379500 B CN108379500 B CN 108379500B CN 201810421136 A CN201810421136 A CN 201810421136A CN 108379500 B CN108379500 B CN 108379500B
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traditional chinese
wheat
chinese medicine
medicine composition
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CN108379500A (en
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刘全
陈典锋
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Chongqing Huanyuan Environmental Science Research Institute Co.,Ltd.
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Chongqing Ansheng Fuxin Enterprise Management Group Co ltd
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
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Abstract

The invention discloses a wheat seedling traditional Chinese medicine composition for nourishing liver, relieving alcoholism, dispelling effects of alcohol and preventing halitosis, a preparation method and application thereof. The wheat seedling traditional Chinese medicine composition mainly comprises the following traditional Chinese medicines in parts by weight: 15-25 parts of wheat sprout, 15-25 parts of gynostemma pentaphylla, 10-20 parts of hawthorn, 10-20 parts of radix puerariae, 1-20 parts of hovenia dulcis thunb, 3-7 parts of fructus amomi, 3-7 parts of clove, 2-5 parts of polydextrose, 3-7 parts of vine tea, 2-4 parts of stevia rebaudiana, 5-15 parts of cinnamon and 10-20 parts of poria cocos. The composition has the effects of nourishing and protecting liver, dispelling the effects of alcohol, sobering up, preventing hangover, preventing and treating fatty liver, preventing halitosis and refreshing breath.

Description

Wheat seedling traditional Chinese medicine composition for nourishing liver, dispelling effects of alcohol, sobering up and preventing halitosis and preparation method thereof
Technical Field
The invention belongs to the field of health-care food, functional beverage, medicinal and edible food (candy, cake, biscuit and the like) or the field of traditional Chinese medicine, and particularly relates to a wheat seedling traditional Chinese medicine composition for nourishing liver, dispelling effects of alcohol, sobering up and preventing halitosis, a preparation method and application thereof.
Background
The main component of the wine is alcohol, which is chemically named as ethanol. Wine is also a food product that has some physical benefit. However, excessive drinking inevitably causes damage to the body. Ethanol enters human body and can generate destruction in various aspects. When the ethanol concentration in blood reaches 0.05%, excitation and euphoria appear; when the concentration of ethanol in blood reaches 0.1%, the person loses self-control ability; when the content reaches 0.2%, people have reached the ground of drunk Ming Dynasty; up to 0.4%, people can lose consciousness, become unconscious and even have life risks. Alcohol has great harm to the human central nervous system, liver system and reproductive system. Can be used for treating polyneuritis, cardiomyopathy, encephalopathy, hematopoietic disorder, pancreatitis, gastritis, ulcer, alcoholic liver cirrhosis, hypertension, laryngeal carcinoma, digestive tract cancer, and reproductive disorder.
However, China is a country with a long history of wine culture, and there are thousands of years of traditional history of drinking, and nearly five hundred million wine citizens. Relatives and friends get together, business, work, etc. all drink alcohol, commonly called as no-alcohol mat. It is inevitable that the wine is not drunk excessively. For alcoholism, a plurality of common methods for folk antialcoholism are used for antialcoholism such as tea, milk, watermelon juice antialcoholism, mung bean soup, honey and the like,
for example, in cases of severe alcoholism, coma, and less than 1 hour, 1 vomit (apomorphine should not be used to avoid the inhibition of ethanol) and gastric lavage (with 0.5% activated charcoal or 1% sodium bicarbonate) should be immediately performed, and if the time exceeds 1 hour, most of ethanol is absorbed into blood, and gastric lavage has no major effect. And then immediately sent to hospital for disposal. 2. For severe poisoning, hemodialysis treatment is feasible to accelerate the removal of ethanol in vivo. 3. For those with hypermania, small doses of diazepam (diazepam) are administered intramuscularly, but morphine and phenobarbital drugs with respiratory inhibitory effect are avoided. 4. For coma and respiratory depression, central stimulant can be used. The naloxone o.4-0.8 mg is used for intramuscular injection or intravenous drip to improve respiration and promote the waking of a patient, and can be repeatedly used once every 2-3 hours if necessary. 5. For patients with brain edema, dehydration should be used to reduce intracranial pressure, and 20% mannitol and fructoglycerin may be used. 6. The intravenous injection of hypertonic sugar, insulin and vitamin b6 can accelerate the oxidation of ethanol in vivo and promote the medical anti-hangover method.
CN104288652 discloses a traditional Chinese medicine composition with anti-alcoholism health efficacy, which comprises 5-15 parts of hovenia dulcis thunb, 5-15 parts of kudzu root, 0.5-7.5 parts of pueraria lobata, 0.5-7.5 parts of dried orange peel, 1-10 parts of medicated leaven, 1-10 parts of malt, 1-10 parts of scorched hawthorn fruit, 5-15 parts of oak root, 0.4-7 parts of fructus amomi, 0.8-9 parts of radish seed and 1-10 parts of poria cocos. The traditional Chinese medicine composition is prepared from pure traditional Chinese medicines according to the monarch, minister, assistant and guide traditional Chinese medicine theory, and has the effects of relieving alcoholism, quenching thirst, relieving restlessness, strengthening spleen and stomach, soothing liver, promoting qi circulation, inducing diuresis, excreting dampness and calming heart. However, the traditional Chinese medicine composition has long hangover alleviating time and uncomfortable taste.
The invention discloses an anti-alcoholism tea and a preparation method thereof, and CN 104286287. The tea for relieving alcoholism is prepared from 13 raw materials of kudzu root, lotus leaf, wrinkled gianthyssop herb, stevia rebaudiana, grosvenor momordica fruit, galangal, hovenia dulcis thunb, honeysuckle, liquorice, rhizoma polygonati, hawthorn, malt, dried orange peel and the like. But the anti-alcoholism tea still has poor curative effect and slow sobering speed.
It can be seen that for moderate and deep alcoholism, the traditional Chinese medicine preparation mainly takes chemical medicines and traditional Chinese medicine preparations, the chemical medicines can cause metabolic burden to liver and kidney, and have large side effect, while the traditional Chinese medicine preparation has small side effect, but has slow effect and insignificant curative effect.
Disclosure of Invention
The invention aims to provide a wheat seedling traditional Chinese medicine composition for nourishing liver, relieving alcoholism, dispelling effects of alcohol and preventing halitosis. The Chinese medicinal composition has effects of relieving hangover, nourishing liver, and protecting liver, and especially has effects of relieving hangover, preventing drunkenness, and preventing and treating fatty liver and halitosis.
The invention relates to a wheat seedling traditional Chinese medicine composition for nourishing liver, relieving alcoholism, dispelling effects of alcohol and preventing halitosis, which mainly comprises the following traditional Chinese medicines in parts by weight: 15-25 parts of wheat sprout, 15-25 parts of gynostemma pentaphylla, 10-20 parts of hawthorn, 10-20 parts of radix puerariae, 1-20 parts of hovenia dulcis thunb, 3-7 parts of fructus amomi, 3-7 parts of clove, 3-7 parts of polydextrose, 3-7 parts of vine tea, 2-4 parts of stevia rebaudiana, 5-15 parts of cinnamon and 10-20 parts of poria cocos.
Preferably, the wheat seedling traditional Chinese medicine composition for nourishing liver, removing halitosis and preventing hangover mainly comprises the following traditional Chinese medicines in parts by weight: 20 parts of wheat seedlings, 20 parts of gynostemma pentaphylla, 15 parts of hawthorn, 15 parts of kudzu root, 15 parts of hovenia dulcis thunb, 5 parts of fructus amomi, 5 parts of clove, 5 parts of polydextrose, 5 parts of vine tea, 3 parts of stevia rebaudiana, 10 parts of cinnamon and 15 parts of poria cocos.
In a specific embodiment, the wheat seedling traditional Chinese medicine composition for nourishing liver, relieving alcoholism, dispelling effects of alcohol and preventing halitosis mainly comprises the following traditional Chinese medicines in parts by weight: 20g of wheat sprout, 20g of gynostemma pentaphylla, 15g of hawthorn, 15g of radix puerariae, 15g of semen hoveniae, 5g of fructus amomi, 5g of clove, 5g of polydextrose, 5g of vine tea, 3g of stevia rebaudiana, 10g of cinnamon and 15g of poria cocos.
In the wheat seedling traditional Chinese medicine composition, the wheat seedlings are wheat seedlings or barley seedlings.
The preparation forms of the wheat seedling Chinese medicinal composition are granules, tablets, capsules, chewable tablets, oral liquid, functional beverages, candies, biscuits and cakes.
The above-mentioned wheat seedling Chinese medicinal composition of the invention, the chewable tablet, further comprises adjuvants or additives, such as sorbitol 1-5%, peppermint powder essence 0.1-0.15%, citric acid 0.05-0.1%, magnesium stearate 0.3-0.5%, etc.
The wheat seedling Chinese medicinal composition of the invention further comprises additives such as 1 to 5 weight percent of sorbitol, 0.1 to 0.15 weight percent of mint powder essence, 0.05 to 0.1 weight percent of citric acid and the like.
The invention aims to provide a preparation method of a wheat seedling traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is a chewable tablet, and the preparation method comprises the following steps:
1) weighing wheat seedlings according to the weight ratio, boiling the wheat seedlings (wheat seedlings or barley seedlings) for 5-10 minutes, and drying at low temperature for 1-2 hours, so that the loss of nutrition is reduced, and the original flavor and taste of the wheat seedlings are maintained; grinding the wheat seedlings to reach the fineness of 800-;
2) adding gynostemma pentaphyllum, hawthorn, vine tea, kudzuvine root, hovenia dulcis thumb, stevia rebaudiana, poria cocos and cinnamon into 6 times of water by weight of the medicine, decocting for 30-45 minutes, adding fructus amomi and clove, decocting for 3-10 minutes, preferably 5 minutes, and keeping volatile active ingredients of the fructus amomi and clove from volatilizing to obtain a decoction; concentrating the Chinese medicinal water extract to 1: 1-1: 2 (ml: g), cooling the medicinal liquid, slowly adding ethanol under stirring to reach specified ethanol content of 70-80%, sealing, refrigerating for 24-48 hr, filtering, and recovering ethanol from the filtrate to obtain refined solution.
3) Putting the refined liquid obtained in the step 2) into a reaction kettle, heating to 40-60 ℃, adding 5g of polydextrose, 1-5% of sorbitol, 0.1-0.15% of mint powder essence, 0.05-0.1% of citric acid and 0.3-0.5% of magnesium stearate (the weight percentages are calculated according to the refined liquid obtained in the step 2), stirring for 5-10 minutes, continuously heating to 80-100 ℃, and preserving heat for 5-10 minutes to obtain a first mixed liquid;
4) adding the fine powder obtained in the step 1) into the first mixed solution obtained in the step 3), and stirring for 5-10 minutes to obtain a second mixed solution;
5) freeze drying the second mixture at-40 deg.C to-30 deg.C for 15-24 hr, wet granulating, and tabletting to obtain chewable tablet or oral tablet, or capsule or granule.
6) And (3) sterilizing the chewable tablet finished product obtained in the step 5) by ultraviolet rays with the wavelength of 250-300 nm, packaging, and preserving at normal temperature.
The invention also aims to provide a wheat seedling traditional Chinese medicine composition for nourishing liver, relieving alcoholism, dispelling effects of alcohol and preventing halitosis, which is an oral beverage, and the method comprises the following steps:
1) weighing the traditional Chinese medicinal materials of wheat sprout, gynostemma pentaphylla, hawthorn, vine tea, kudzu root, hovenia dulcis thunb, fructus amomi, clove, polydextrose and stevia rebaudiana in parts by weight, adding cinnamon and poria cocos, and adding 8 times of water to extract for three times, wherein each time lasts for 1.5 hours;
2) mixing decoctions, filtering, and concentrating to relative density of 1.10; adding adjuvants such as sorbitol, herba Menthae powder essence, citric acid, etc., stirring for dissolving, and filtering to obtain filtrate;
3) adding water into the filtrate, adjusting the relative density of the solution to 1.06, bottling, sterilizing, labeling, and packaging.
The traditional Chinese medicine composition with the effects of nourishing liver, protecting liver, dispelling alcohol effects and preventing halitosis is prepared by adopting the pure traditional Chinese medicines as raw materials and combining the raw materials according to the monarch, minister, assistant and guide traditional Chinese medicine theory, overcomes the defect of single effect of single medicine, particularly emphasizes the compatibility proportion of the dosages among the components, enhances the drug effect, regulates and controls in multiple aspects, and achieves the effects of nourishing liver, protecting liver, dispelling alcohol effects and protecting health: the wheat seedlings, the gynostemma pentaphylla, the hovenia dulcis thunb and the kudzuvine roots are taken as monarch drugs, so that the effects of clearing away heat and toxic materials, promoting the production of body fluid to quench thirst and relieving restlessness, protecting liver and relieving alcoholism are achieved; poria cocos, fructus amomi, hawthorn and clove are used as ministerial drugs for regulating qi, strengthening spleen, promoting digestion, resolving stagnation, harmonizing stomach, stopping vomiting, soothing liver, regulating qi, harmonizing stomach and stopping vomiting; the ampelopsis grossedentata has the effects of clearing heat and removing toxicity, relieving pain and reducing swelling, the cinnamon can guide fire to the origin, promote blood circulation and promote menstruation, warm the spleen and stomach and remove cold accumulation, and the cold and heat in the cinnamon can be used as adjuvant drugs to ensure that the heat is cleared without damaging the original qi; stevia rebaudiana and polydextrose are used as guiding drugs, and the medicines are combined to achieve the health-care effects of nourishing and protecting liver, strengthening spleen and stomach, and dispelling the effects of alcohol and sobering up. Modern pharmacological research shows that the main components of the composition, namely the wheat sprout, the gynostemma pentaphylla, the kudzuvine root, the hawthorn, the vine tea and the like, have the effects of obviously reducing blood fat, protecting the liver and improving the immunity.
The wheat seedling traditional Chinese medicine composition for nourishing the liver, dispelling the effects of alcohol and preventing and treating the fatty liver and the ozostomia has the effects of nourishing the liver, protecting the liver, dispelling the effects of alcohol and dispelling the effects of alcohol. And has effects of relieving hangover and preventing hangover.
The specification of the chewable tablet or tablet prepared from the wheat seedling traditional Chinese medicine composition is 0.5 g/tablet or 0.3 g/tablet, 1-3 tablets are taken each time, and the daily dose is not more than 5 g.
The beverage prepared from the wheat seedling traditional Chinese medicine composition has the specification of 125 ml/bottle, 330 ml/bottle or 500 ml/bottle, and the daily volume is not more than 1500 ml.
Detailed Description
The following examples are presented to further understand and illustrate the spirit of the present invention, but are not intended to limit the scope of the present invention in any way.
Example 1 wheat seedling Chinese medicinal composition
The formula is as follows:
20g of wheat seedlings, 20g of gynostemma pentaphylla, 15g of hawthorn, 15g of radix puerariae, 15g of hovenia dulcis thunb, 5g of fructus amomi, 5g of clove, 5g of polydextrose, 5g of vine tea, 3g of stevia rebaudiana, 10g of cinnamon and 15g of poria cocos.
The preparation process of the chewable tablet of the composition preparation comprises the following steps:
1) weighing wheat seedlings according to weight, boiling the wheat seedlings (wheat seedlings or barley seedlings) for 5-10 minutes, and drying at low temperature for 1-2 hours, so as to reduce nutrition loss and keep the original flavor and taste of the wheat seedlings; grinding the wheat seedlings to reach the fineness of 800-;
2) adding gynostemma pentaphyllum, hawthorn, vine tea, kudzuvine root, hovenia dulcis thumb, stevia rebaudiana, poria cocos and cinnamon into 6 times of water by weight of the medicine, decocting for 30-45 minutes, adding fructus amomi and clove, decocting for 3-10 minutes, preferably 5 minutes, and keeping volatile active ingredients of the fructus amomi and clove from volatilizing to obtain a decoction; concentrating the Chinese medicinal water extract to 1: 1-1: 2 (ml: g), cooling the medicinal liquid, slowly adding ethanol under stirring to reach specified ethanol content of 70-80%, sealing, refrigerating for 24-48 hr, filtering, and recovering ethanol from the filtrate to obtain refined solution.
3) Putting the refined liquid obtained in the step 2) into a reaction kettle, heating to 40-60 ℃, adding 5g of polydextrose, 3% of sorbitol, 0.12% of mint powder essence, 0.08% of citric acid and 0.4% of magnesium stearate (calculated by the weight percentage of the refined liquid obtained in the step 2), stirring for 5-10 minutes, continuously heating to 80-100 ℃, and preserving heat for 5-10 minutes to obtain a first mixed liquid;
4) adding the fine powder obtained in the step 1) into the first mixed solution obtained in the step 3), and stirring for 5-10 minutes to obtain a second mixed solution;
5) freeze drying the second mixture at-40 deg.C to-30 deg.C for 15-24 hr, granulating by wet method, and tabletting to obtain chewable tablet (0.5 g/tablet or 0.3 g/tablet), 1-3 tablets for each administration.
6) And (3) sterilizing the chewable tablet finished product obtained in the step 5) by ultraviolet rays with the wavelength of 250-300 nm, packaging, and preserving at normal temperature.
The preparation process of the oral beverage of the composition preparation comprises the following steps:
the method comprises the following steps:
1) weighing the traditional Chinese medicinal materials of wheat sprout, gynostemma pentaphylla, hawthorn, vine tea, kudzu root, hovenia dulcis thunb, fructus amomi, clove, polydextrose, stevia rebaudiana, cinnamon and poria in parts by weight, and adding 8 times of water to extract for three times, wherein each time lasts for 1.5 hours;
2) mixing decoctions, filtering, and concentrating to relative density of 1.10; adding appropriate amount of flavoring agent (or called additive) such as sorbitol, herba Menthae powder essence, citric acid, etc., stirring for dissolving, and filtering to obtain filtrate;
3) adding water into the filtrate, adjusting the relative density of the solution to 1.06, bottling, sterilizing, labeling, and packaging to obtain beverage or solution. Specification: 125 ml/bottle or 330 ml/bottle or 500 ml/bottle.
Examples the recipe of the composition of the Maiqingmiao traditional Chinese medicine, each example and comparative example is shown in Table 1.
TABLE 1 recipes for examples 2-4 and comparative examples 1-3
Figure GDA0002603126470000061
The above formulation (unit weight g or parts by weight) was prepared into chewable tablets or oral liquids by the process of example 1, and the amount of the flavoring agent for oral liquids or beverages was appropriately adjusted according to actual conditions with reference to the amount of example 1.
Animal hangover effect test
The experimental scheme is as follows:
120 experimental mice were randomly grouped as follows:
Figure GDA0002603126470000071
and (3) treatment: after all mice fasted for one night, positive control group A was prepared into 0.125g/mL suspension by using Japanese Anxingxian sobering-up pills and then filled with drinking water, and drug test group B group 1 was prepared into 0.15g chewable tablets of example 1 (according to the weight of the mice, 0.15g chewable tablets of example 1 were dissolved in pure water to prepare mixed solutions respectively and filled with stomach). Drug test group B group 2 was gavaged with 1.5ml of the solution of example 1. Comparative test group C was intragastrically infused with the solution of comparative example 1 and comparative test group D was intragastrically infused with the solution of comparative example 2. Comparative test group E the solution of comparative example 3. And (3) after the gavage is carried out for 30min, carrying out gavage on groups A-E by using alcohol, carrying out gavage on mice in each group by using 2ml of 53-degree white spirit, carrying out gavage for 1h, randomly taking one half of the mice, taking eyeballs, and taking blood after the other half of the mice are filled with the alcohol for 2 h.
Determination of ethanol content in mouse blood
And (3) taking blood twice, putting the blood in a 1.5mL centrifuge tube, adding heparin sodium for anticoagulation, standing in a water bath at 37 ℃ for 15min, and centrifuging at 3000r/min for 15min to obtain plasma. The ethanol content in the blood of the mouse is determined by adopting a blood ethanol determination kit and a full-automatic biochemical analyzer. The results of statistical analysis of the blood ethanol volume concentration differences of mice in the positive control group A, the comparative test group C/D/E and the sample test group B are shown in Table 2
Table 2 blood ethanol volume concentration% of each test group
Figure GDA0002603126470000072
Figure GDA0002603126470000081
In conclusion, the traditional Chinese medicine composition with the anti-alcoholism and health-care effects can obviously prolong the drunk latency period and obviously reduce the blood ethanol content within two hours after drinking; the enlightenment can effectively improve the total activity of the alcohol dehydrogenase and the acetaldehyde dehydrogenase, and has obvious antialcoholic and health-care effects.
Hangover alleviation test for healthy volunteers
Evaluation experiment of hangover alleviating efficiency
Healthy volunteers were recruited 60, male, 20-30 years old, with no history of disease and no allergy to alcohol. Volunteers were divided into 6 groups: positive control group a, medication test groups B1 and B2, control test group C, control test group D, control test group E, 10 people per group. Wherein, the positive control group takes the Riben Anhuixian pill for relieving alcoholism, and the medication test groups B1 and B2 respectively take the chewable tablets and the oral liquid of example 1, and the comparison test group C, the comparison test group D and the comparison test group E respectively take the chewable tablets of comparison examples 1, 2 and 3. The volunteers drunk wine at the same time, and drunk the Jiangjin white spirit with the alcohol content of 52 degrees within a specified time. The time each volunteer was awake was measured.
The test results are shown in Table 3
TABLE 3 time of awakening (hours) for each volunteer
Figure GDA0002603126470000082
Figure GDA0002603126470000091
The results in table 3 show that the anti-hangover Chinese medicinal composition of the present invention has significant advantages over the Chinese medicinal compositions of the comparative examples in the time of sobering up. But also is obviously better than the positive control drug Nippon Anzuixian pill for relieving alcoholism.
The results of animal experiments and human body experiments show that the wheat seedling Chinese medicinal composition has very good anti-inebriation effect. The composition of the invention is also proved to have obviously different antialcoholic effects due to the deletion of components, particularly wheat seedlings or the replacement change of other components, and the antialcoholic efficacy of the composition is proved to be extremely superior.
The anti-alcoholism liver-protecting effect of the anti-alcoholism traditional Chinese medicine composition on acute alcoholism of rats is researched, and related action mechanisms are discussed.
The method comprises the step of randomly dividing 45 SD rats into a normal group (15 rats), a model group (15 rats) and an experimental group (15 rats) (the anti-alcoholism traditional Chinese medicine composition beverage of the invention is taken by filling).
Preparation of the test: the sobering-up traditional Chinese medicine composition beverage of the embodiment 1 of the invention is used for intragastric administration in a dosage of 1.5ml/100gwt, twice a day, 7h interval every time, and the normal group and the model group are administrated with the same dosage of drinking water for intragastric administration for 3 d. After the 2 nd administration on the third day, after fasting and water deprivation for 14 hours, the experimental group is subjected to 1.5ml/100gwt intragastric administration on the hangover-alleviating traditional Chinese medicine composition beverage, and the normal group and the model group are subjected to intragastric administration on the same amount of drinking water. After 1h, the model and experimental groups replicated the rat alcoholism model by gavage with 55% ethanol at 1.5ml/100 gpt.
Observation indexes are as follows: after the stomach is perfused with ethanol, observing the disappearance time of turn-over reflex and the lethargy time of the rats after the alcohol is perfused, carrying out intraperitoneal injection on 3 percent sodium pentobarbital for anesthetizing the rats 24 hours later, and reserving serum and liver tissue samples for detecting related indexes, namely AST and ALT activities of the serum; liver tissue HE staining; ③ measuring the alcohol metabolizing enzyme index, namely the Acetaldehyde Dehydrogenase (ADH) activity of serum and liver tissues; and fourthly, lipid peroxidation indexes, namely the content of reduced Glutathione (GSH) and serum iron in the liver, the activity of glutathione-peroxidase (GSH-Px), Nitric Oxide Synthase (NOS) and Inducible Nitric Oxide Synthase (iNOS).
And (3) test results:
compared with a model group, the disappearance time of the turning-over reflex of the rats in the experimental group after the rats are filled with alcohol is obviously prolonged (P0.01), and the lethargy time is shortened (P0.05);
compared with a model group, the serum AST activity of an experimental group is remarkably reduced (P0.01), the ALT activity has a descending trend, but no statistical difference (P0.05) exists;
the HE staining of the liver tissue shows that the fatty degeneration of the liver cells of the experimental group is reduced compared with the fatty degeneration of the liver cells of the model group, and the formation of fat vacuoles in the liver cells is reduced compared with the fatty vacuoles of the model group;
compared with a model group, the ADH activity of the liver tissue in the alcohol metabolizing enzyme indexes of the experimental group is obviously improved (P0.01).
Compared with the model group, the GSH activity of the liver tissue of the experimental group is obviously improved (P0.01), and the TNOS and iNOS activities of the liver tissue are obviously reduced (P0.05).
The conclusion is that the anti-alcoholism traditional Chinese medicine composition has the effects of protecting liver and relieving alcoholism on rats with acute alcoholism for 24 hours. The anti-alcohol action mechanism is as follows: slow down the absorption of ethanol in vivo, promote the ADH activity of the liver and accelerate the metabolism of ethanol. The liver protection mechanism of the medicine is to improve GSH level, inhibit TNOS and iNOS expression, protect mitochondria and reduce lipid peroxidation.
Meanwhile, animal and human experiments using the compositions formulated in examples 2 to 4 found that they had the same anti-hangover effect and liver-protecting effect as the composition of example 1.
Simple variations of the composition ingredients within the spirit of the present invention, including combinations of extracts of each of the medicinal materials or single actives thereof in the composition, are also within the scope of the present invention.

Claims (10)

1. A wheat seedling traditional Chinese medicine composition for nourishing liver, relieving alcoholism, dispelling effects of alcohol and preventing halitosis is prepared from the following traditional Chinese medicines in parts by weight: 15-25 parts of wheat sprout, 15-25 parts of gynostemma pentaphylla, 10-20 parts of hawthorn, 10-20 parts of radix puerariae, 1-20 parts of hovenia dulcis thunb, 3-7 parts of fructus amomi, 3-7 parts of clove, 2-5 parts of polydextrose, 3-7 parts of vine tea, 2-4 parts of stevia rebaudiana, 5-15 parts of cinnamon and 10-20 parts of poria cocos.
2. The wheat seedling traditional Chinese medicine composition of claim 1, which is prepared from the following traditional Chinese medicines in parts by weight: 20 parts of wheat seedlings, 20 parts of gynostemma pentaphylla, 15 parts of hawthorn, 15 parts of kudzu root, 15 parts of hovenia dulcis thunb, 5 parts of fructus amomi, 5 parts of clove, 2-5 parts of polydextrose, 5 parts of vine tea, 3 parts of stevia rebaudiana, 10 parts of cinnamon and 15 parts of poria cocos.
3. The wheat seedling traditional Chinese medicine composition of claim 2, which is prepared from the following traditional Chinese medicines in parts by weight: 20g of wheat sprout, 20g of gynostemma pentaphylla, 15g of hawthorn, 15g of kudzu root, 15g of hovenia dulcis thunb, 5g of fructus amomi, 5g of clove, 5g of polydextrose, 5g of vine tea, 3g of stevia rebaudiana, 10g of cinnamon and 15g of poria cocos.
4. The Chinese medicinal composition of claim 1, which is in the form of granule, tablet, capsule, or oral liquid.
5. The Chinese medicinal composition of claim 4, further comprising additives or adjuvants including: 1 to 5 percent of sorbitol, 0.1 to 0.15 percent of mint powder essence, 0.05 to 0.1 percent of citric acid or 0.3 to 0.5 percent of magnesium stearate.
6. The wheat seedling Chinese medicinal composition of claim 1, wherein the wheat seedlings are wheat seedlings or barley seedlings.
7. A method of preparing the wheat seedling herbal composition of claim 1, comprising the steps of:
1) the wheat seedlings are boiled for 5-10 minutes and dried at low temperature for 1-2 hours, so that the loss of nutrition is reduced, and the original flavor and taste of the wheat seedlings are maintained; grinding the wheat seedlings to reach the fineness of 800-;
2) adding herba Gynostemmatis, fructus crataegi, Ampelopsis grossedentata, radix Puerariae, semen Hoveniae, sweet stevia, Poria and cortex Cinnamomi into 6 times of water, decocting for 30-45 min, adding fructus Amomi and flos Caryophylli, decocting for 3-10 min, and keeping volatile active components of fructus Amomi and flos Caryophylli from volatilizing to obtain decoction; concentrating the Chinese medicinal water extract to 1: 1-1: 2 (ml: g), cooling the medicinal liquid, slowly adding ethanol under stirring to reach specified ethanol content of 70-80%, sealing, refrigerating for 24-48 hr, filtering, and recovering ethanol from the filtrate to obtain refined solution.
3) Putting the refined liquid obtained in the step 2) into a reaction kettle, heating to 40-60 ℃, adding 5g of polydextrose, 1-5% of sorbitol, 0.1-0.15% of mint powder essence, 0.05-0.1% of citric acid and 0.3-0.5% of magnesium stearate, stirring for 5-10 minutes according to the weight percentage of the refined liquid, continuously heating to 80-100 ℃, and preserving heat for 5-10 minutes to obtain a first mixed liquid;
4) adding the fine powder obtained in the step 1) into the first mixed solution obtained in the step 3), and stirring for 5-10 minutes to obtain a second mixed solution;
5) freeze drying the second mixture at-40 deg.C to-30 deg.C for 15-24 hr, wet granulating, and tabletting to obtain chewable tablet or oral tablet or capsule or granule.
8. A method of preparing the wheat seedling herbal composition of claim 1, comprising the steps of:
1) adding cortex Cinnamomi and Poria into herba Vaccinii Bracteati seedling, herba Gynostemmatis, fructus crataegi, Ampelopsis grossedentata, radix Puerariae, semen Hoveniae, fructus Amomi, flos Caryophylli, polydextrose, and sweet stevia, extracting with 8 times of water for three times, each time for 1-2 hr, and mixing decoctions;
2) filtering the decoction, and concentrating the filtrate to obtain a concentrated solution with a relative density of 1.10;
3) adding adjuvants such as sorbitol, herba Menthae powder essence, citric acid, etc., stirring for dissolving, and filtering to obtain filtrate;
4) adding water into the filtrate to adjust the relative density of the solution to 1.06 to obtain the Chinese medicinal oral liquid.
9. The method according to claim 7, wherein the step 2) comprises decocting fructus Amomi and flos Caryophylli for 5 min.
10. The method of claim 8, wherein the water extraction time in step 1) is 1.5 hours.
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