CN103860880A - Loquat leaf extract and preparing method thereof - Google Patents

Abstract

The invention discloses loquat leaf extract and a preparing method thereof. The loquat leaf extract is prepared from following raw materials by weight: 200-400 parts of loquat fruit, 6-10 parts of radix glehniae, 5-9 parts of flos farfarae, 8-12 parts of Sichuan fritillary bulb fluid extract, 5-9 parts of licorice extract powder, 5-9 parts of fragrant colomonaeal rhizome, 6-10 parts of Chinese violet and 4-8 parts of ilex rotunda thumb. The preparing method includes steps of: preparing the Sichuan fritillary bulb fluid extract, preparing traditional Chinese medicine extract, smashing by a smasher to obtain loquat meat, adding the loquat meat and white granulated sugar into the obtained traditional Chinese medicine thick paste, boiling for 2 h, filtering, mixing the filtrate, the 8-12 parts of the Sichuan fritillary bulb fluid extract and the 5-9 parts of the licorice extract powder, stirring uniformly, concentrating the filtrate at a temperature lower than 60 DEG C until the relative density is 1.25-1.40, cooling, adding menthol when the temperature is lowered to be 55 DEG C, adding water to a specified amount and stirring uniformly.

Description

A kind of loquat leaf extract and preparation method thereof

Technical field

The invention belongs to health product and field of medicaments, especially belong to a kind of loquat leaf extract that adopts traditional Chinese medicine one-tenth and preparation method thereof.

Background technology

Folium Eriobotryae is different from most of fruit tree, in autumn or open early winter luxuriant, fruit in spring to maturation early summer, all more Zao than other fruit, therefore claimed to be solely standby seasonal pathogens,exopathogens person in fruit tree, ripe Folium Eriobotryae fruit is that bunchy is hung in the tree, ripe Folium Eriobotryae taste is pretty good, nutrition is rich, there are various fructose, glucose, potassium, phosphorus, ferrum, calcium and vitamin A, B, C etc., leaf and fruit is used as medicine, and has the effects such as heat clearing away, lung moistening, relieving cough and resolving phlegm, and the traditional Chinese medical science is thought the function that loquat has lung moistening, cough-relieving, quenches the thirst.

The existing many reports of medicine at present with nourishing YIN and moistening the lung and eliminating phlegm and stopping cough, if application number is 2008100724915, its formula is: Flos Eriobotryae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis and Semen Armeniacae Amarum, in formula, generally all use Folium Eriobotryae, Flos Eriobotryae etc., seldom see employing Fractus Eriobotryae; And Chinese crude drug composition is also less in described formula, these have all restricted as treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to stagnation of fire in the interior, laryngopharynx swelling and pain, breast distending pain, the effect of the symptoms such as cold cough and chronic bronchitis.

Summary of the invention

The object of the present invention is to provide a kind of cough eliminated symptom that several kinds of Chinese medicinal materials and Fractus Eriobotryae be mixed with and loquat leaf extract of healing and preparation method thereof of adopting.

The object of the present invention is achieved like this, described a kind of loquat leaf extract and preparation method thereof, and it is to be made up of the raw material of following weight proportioning:

Fractus Eriobotryae 200-400 part, Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Bulbus Fritillariae Cirrhosae fluidextract 8-12 part, radix Glycyrrhizae extractum powder5-9 part ,rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part.

The preparation method of Bulbus Fritillariae Cirrhosae fluidextract is as follows: following % is weight percentage.

The present inventor studies intensively and clinical verification continuously through two more than ten years, and this loquat leaf extract has treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to stagnation of fire in the interior, laryngopharynx swelling and pain, breast distending pain, the symptoms such as cold cough and chronic bronchitis.In formula 1) Fractus Eriobotryae: [performance] sweet in the mouth, micro-acid, cool in nature.Energy nourishing the lung to arrest cough, promoting the production of body fluid to quench thirst, regulating the stomach and sending down the abnormal ascending QI.[reference] sarcocarp is sugary, protein, fat, pectin, carotene, vitamin B1, C, the compositions such as tartaric acid, malic acid, citric acid.[purposes], for lung-dryness syndrome due to deficiency of YIN, coughs, or spitting of blood; Deficiency of stomach-Yin, dry throat and mouth, or QI failing to descend, retch loss of appetite.[usage] eaten raw, endures cream, or decocts soup.2) Radix Glehniae, [function cures mainly] nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.3) Flos Farfarae, function with cure mainly:nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.4) Bulbus Fritillariae Cirrhosae, [function cures mainly] clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Control cough due to consumptive disease, the spitting of blood of spitting, ambition Yu Jie, consumptive lung disease, lung abscess, sore throat, acute mastitis; 5) Rhizoma Polygonati Odorati, nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain; 6) Herba Violae, function cures mainly:can be used as medicine, its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood detumescence.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.7) Ilex rotunda Thunb., effect: heat-clearing and toxic substances removing; Dampness removing; Pain relieving.Cold, fever; Laryngopharynx swelling and pain; Stomachache; Administration's diarrhea due to damp pathogen rushes down; Jaundice; Dysentery; Traumatic injury; Rheumatic arthralgia; Eczema; Furuncle.All medicines share above, have clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, and removing stasis to stop bleeding, the merit of nourishing qi to stop, assistant helps all medicines of the monarch and his subjects to control all diseases of cough, flu altogether.

Can do paste making agent, oral solid formulation or the oral liquid etc. of Chinese medicine preparation of the present invention all can.

The preparation method of loquat leaf extract of the present invention: Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to (appendix IO of Chinese Pharmacopoeia version in 2000) percolation under fluid extract and extractum item, makes solvent with 70% ethanol, flood after 5 days, slowly percolation, collects the liquid of just filtering, another device is preserved, continue percolation, the soluble component of waiting is filtered out completely, gets the liquid of filtering and is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density at 60 ℃ and be 1.1～1.2 Bulbus Fritillariae Cirrhosae thick paste, for subsequent use; The Radix Glehniae, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygonati Odorati, Herba Violae, the Ilex rotunda Thunb. that take in proportion above-mentioned formula ratio decoct with water secondary, boiling temps can reach 120 ℃, 2-3 hour for the first time, 1.5-2.5 hour for the second time, collecting decoction, filter to obtain filtrate, filtrate is concentrated into relative density and is preferably 1.25～1.40 Chinese crude drug thick paste (being as the criterion take temperature as 60 ℃).Chinese crude drug thick paste adds Folium Eriobotryae meat, also can add appropriate white sugar, boils 1-3 hour, and boiling temps can reach 110 ℃, filter, filter screen can be 20 object filter screens, filtrate and Bulbus Fritillariae Cirrhosae thick paste with radix Glycyrrhizae extractum powdermix homogeneously, continuing to be concentrated into relative density at 60 ℃ is 1.25～1.40, lets cool, and is cooled to after 55 ℃, can add adjuvant Mentholum, adds water to ormal weight, stirs evenly, and to obtain final product, and bottles, sterilizes, seals, is packaged into product.Mentholum can account for the 0.05-0.12% of gross weight.

Above-mentioned Folium Eriobotryae meat is that ripe Folium Eriobotryae is removed skin and pit, after wash clean, obtains by crusher in crushing.

Loquat leaf extract of the present invention belongs to oral type unguentum, adult every day 2～3 times, each soupspoon (about 15mL).

Because loquat leaf extract of the present invention is take loquat fruit as primary raw material, take Radix Glehniae, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygonati Odorati, Herba Violae, Ilex rotunda Thunb. as Chinese crude drug and sucrose as adjuvant, therefore there is the function of clearing away lung-heat to relieve cough and stopping nausea and vomiting by lowering the adverse flow of QI, for the few dry pharynx of lung-heat type cough, expectorant, stay up late and tobacco and wine are excessive etc. has a good effect.The function of have lung moistening, cough-relieving, quenching the thirst.In addition, production technology of the present invention is simple, there is no environmental pollution.

Loquat leaf extract of the present invention is treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to stagnation of fire in the interior, laryngopharynx swelling and pain, breast distending pain, the oral syrup class pure Chinese medicinal preparation of the symptom such as cold cough and chronic bronchitis, through clinical verification for many years, steady quality, determined curative effect is the common drug preparation that clinical and family is used for the treatment of above disease.Other similar oral formulations also has the watered pill, tablet etc., and its feature is similar, act on basic identical, without significant difference.

The specific embodiment

Below in conjunction with embodiment, the present invention is described in detail:

Embodiment

1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:

Get 50 grams of Bulbus Fritillariae Cirrhosaes and be ground into coarse powder, ooze method according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation, collects the liquid of just filtering, another device is preserved, continue percolation, the soluble component of waiting is filtered out completely, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density at 60 ℃ and be 1.1～1.2 thick paste, stand-by.

2) preparation method of Chinese medicine extract:

6 grams of 8 grams of Radix Glehniaes, 7 grams of Flos Farfaraes, 7 grams of Rhizoma Polygonati Odorati, 8 grams of Herba Violaes, Ilex rotunda Thunb. are decocted with water to secondary, and boiling temps is 120 ℃, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtered, at 60 ℃ filtrate to be concentrated into relative density be 1.35 Chinese crude drug thick paste, stand-by;

3) ripe Folium Eriobotryae is removed to skin and pit, the Folium Eriobotryae meat obtaining by crusher in crushing after wash clean, for subsequent use.

4) by step 2) Folium Eriobotryae meat that the Chinese crude drug thick paste that obtains adds 300 grams of step 3) to obtain, be at 100 ℃, to boil 2 hours at boiling temps, filter filtrate and above-mentioned steps 1) 10 grams of the Bulbus Fritillariae Cirrhosae fluidextracts that obtain with radix Glycyrrhizae extractum powder7 grams of mix and blends make evenly, at 60 ℃ filtrate to be concentrated into relative density be 1.35, let cool, be cooled to after 55 ℃, add water to ormal weight, stir evenly, to obtain final product, bottle, sterilize, seal, be packaged into product.

Claims (2)

1. a loquat leaf extract, is characterized in that it is to be made up of the raw material of following weight proportioning:

Fractus Eriobotryae 200-400 part, Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, radix Glycyrrhizae extractum powder5-9 part ,bulbus Fritillariae Cirrhosae fluidextract 8-12 part, Rhizoma Polygonati Odorati 5-9 part, herba Violae 6-10 part, Ilex rotunda Thunb.4-8 part.

2. the preparation method of a kind of loquat leaf extract claimed in claim 1, comprises the steps:

1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:

Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, ooze method according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation, collects the liquid of just filtering, another device is preserved, continue percolation, the soluble component of waiting is filtered out completely, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density at 60 ℃ and be 1.1～1.2 thick paste, stand-by;

2) preparation method of Chinese medicine extract:

by Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb.4-8 part, decoct with water secondary, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtered, at 60 ℃ filtrate to be concentrated into relative density be 1.25～1.40 Chinese crude drug thick paste, stand-by;

3) ripe Folium Eriobotryae is removed to skin and pit, the Folium Eriobotryae meat obtaining by crusher in crushing after wash clean, for subsequent use;

4) by step 2) obtain Chinese crude drug thick paste add 200-400 part step 3) obtain Folium Eriobotryae meat, boil 2 hours, filter, filtrate and above-mentioned steps 1) obtain Bulbus Fritillariae Cirrhosae fluidextract 8-12 part with radix Glycyrrhizae extractum powder5-9 part mix and blend makes evenly, at 60 ℃ filtrate to be concentrated into relative density be 1.25～1.40, let cool, add water to ormal weight, stir evenly, to obtain final product, bottle, sterilize, seal, be packaged into product.