CN101264177A - Tablet forming candy with refreshing, pharynx-clearing and throat-smoothing action - Google Patents
Tablet forming candy with refreshing, pharynx-clearing and throat-smoothing action Download PDFInfo
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- CN101264177A CN101264177A CNA2008100944116A CN200810094411A CN101264177A CN 101264177 A CN101264177 A CN 101264177A CN A2008100944116 A CNA2008100944116 A CN A2008100944116A CN 200810094411 A CN200810094411 A CN 200810094411A CN 101264177 A CN101264177 A CN 101264177A
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Abstract
The invention relates to a compound extraction of refreshing and throat beneficiary effect, comprising essentially 1 to 5 portion of tea extraction, 0.5 to 5 portion of guanala extraction, 0.2 to 5 portion of balloonflower root extraction, 0.2 to 5 portion of Sterculiae Scaphigera extractuibm extraction, 10 to 60 portion of xylitol, 0.2 portion of grosvenor momordica extraction, o.1 to 1 portion of ginger oil, and 0.1 to 1 portion of menthol. The invention still relates to a sugar-free refreshing and throat beneficiary tabletting candy, comprising the compound extraction as the principal agent and medically acceptable accessories.
Description
Technical field
The present invention relates to a kind of compound extract with refreshing, pharynx-clearing and throat-smoothing action, particularly a kind of is the Sugarless type refreshing, pharynx-clearing and throat-smoothing pressed candy of principal agent with described compound extract.
Background technology
Throat is the vitals of human body, and acute and chronic pharyngitis is common clinical, frequently-occurring disease.Especially be engaged in the personnel's of occupations such as literature and art, education, broadcast, sale occupation disease.At present pharyngitis there is not the medicine of specific treatment, therefore should be to put prevention first.
The medicine or the functional food that have the pharynx-clearing throat-benefiting effect at present mostly are liquid type, are inconvenient to carry.Health perception people improves constantly, and today of the taste of confectionary products and outward appearance homogeneity, confectionery industry must be on function seeking breakthrough, could obtain modern's favor.The development of functional confection will be the main trend that confection already develops, and the theory of stressing health, pursuit health care has incorporated confection market.Confection propensity to consume in the world's is towards nutrition, health, low heat value, the development of functional aspect from now on.Sugarless candy is that saccharide such as contained monosaccharide and disaccharidase is below the 0.5g in 100 grams, the sucrose that it adopts sweet ignorant agent low in calories to replace traditional confection to use in making, glucose etc., under the situation that does not reduce the confection sugariness, the heat of confection is reduced greatly, especially be fit to child and diabetes patient.
Sugarless type pressed candy definition: pressed candy is through the confection of pelletize, bonding, compression moulding, can be divided into: 1. nut type (not being in the mood for type) pressed candy: sugared body does not have sandwich pressed candy; 2. sandwich type pressed candy: sugared body has sandwich pressed candy.Pressed candy has advantage easy to carry.
Summary of the invention
The object of the present invention is to provide a kind of compound extract with refreshing, pharynx-clearing and throat-smoothing action, particularly providing a kind of is the Sugarless type refreshing, pharynx-clearing and throat-smoothing pressed candy of principal agent with described compound extract.
The invention discloses a kind of compound extract with refreshing, pharynx-clearing and throat-smoothing action, the principal agent of described compound extract comprises the component of following weight portion: Folium Camelliae sinensis extract 1-5 part, GUANALA extract 0.5-5 part, Radix Platycodonis extract 0.2-5 part, Semen Sterculiae Lychnophorae extract 0.2-5 part, Fructus Momordicae extract 0.2-5 part, xylitol 10-60 part, Mentholum 0.1-1 part.Wherein said Radix Platycodonis extract, Semen Sterculiae Lychnophorae extract and Fructus Momordicae extract have the effect of pharynx-clearing throat-benefiting, and Folium Camelliae sinensis extract, GUANALA extract, Mentholum have the effect of refreshing oneself.
Tea polyphenols is the main functional component of Folium Camelliae sinensis, mainly containing catechin, is a kind of polyphenol component that is present in the Folium Camelliae sinensis, accounts for the 8%-20% of Folium Camelliae sinensis, it is a kind of important chemical constituent with health role in the Folium Camelliae sinensis, has been widely used in food, cosmetics and medical industry.Tea polyphenols is as food additive, as chewing gum, toothpaste, deodorant and elimination halitosis and preventing decayed tooth.Tea polyphenols also has antiinflammatory and itching-relieving action, can eliminate unnecessary free free radical, and it can stop the oxidation of health inner lipid.
GUANALA is the distinctive climbing plant in Amazon area, is the rare precious fruit that is grown in the Amazon, and the likeness in form human eye belongs to half rattan immortality plant, formal name used at school plulula cupana.GUANALA contains rich in amino acid, xanthine plant alkaloid, and therefore Saponin, nicotinic acid become widely used batching in food, the beverage.At present, GUANALA product such as powder, beverage, soda pop and the functional food produced in countries and regions such as Brazil, the U.S., Australia and Europe can be found everywhere, in the soda pop of Brazil 25%, contain the GUANALA composition, the purple star wine that contains GUANALA is also sold in China's bar, this proves absolutely that GUANALA is a bread and cheese, is safe on using.China has listed GUANALA in food additive and has used.
All contain a certain amount of caffeine in green tea and the GUANALA, modern medicine study confirms: caffeine has stronger excitation to cerebral cortex, low dose can strengthen corticocerebral process of excitation, improve thinking activities, inspire enthusiasm, reduce feeling of fatigue, (Xu Shuyun chief editor " clinical application guide " Anhui science and technology 1989 front page P236 of publishing house) are renderd a service in enhancement work.GUANALA and Folium Camelliae sinensis, coffee bean are listed as the raw material of natural caffeine in the world.Australia in 2000 has set up an expert group with New Zealand food control office (ANZFA) caffeine various aspects safety in the food is assessed and monitored.ANZFA thinks: GUANALA is new relatively caffeine raw material, and a lot of consumers do not recognize that GUANALA is a kind of natural caffeine, and as the some of combination food standard rule, ANZFA thinks that the GUANALA beverage can be with reference to containing caffeine beverage standard.
Radix Platycodonis is the traditional medicine food dual purpose plant of China.Studies show that the water extract of Radix Platycodonis has the good in-vitro anti-inflammatory activity, the molecular biology research of inflammatory model due to the lipopolysaccharide is shown that its anti-inflammatory mechanism is the expression of regulation and control NF-B factor active and anti-inflammation gene.Radix Platycodonis has cough-relieving and the effect of reducing phlegm.The early stage platycodin that studies confirm that is its main active.Expectorant activity to monomer saponin studies show that Platycodin D and D recently
3By atomized medicine introducing, can increase the release of mucoitin in the rat epithelial cell; The effect of Platycodin D is stronger than the effect of ATP and Ambroxole.
Semen Sterculiae Lychnophorae is a conventional Chinese medicine, and seed is used as medicine. sweet light. and be slightly cold, go into lung, large intestine channel, open lung, relieving exterior syndrome. relieving sore-throat by clearing away heat, to anemopyretic aphonia, cough, laryngopharynx swelling and pain have good effect, the modern pharmacological research Semen Sterculiae Lychnophorae has stronger inhibitory action to virus, and has analgesia and bacteriostasis.
Fresh fruit is a kind of rare medicinal herbs of fruit Fructus Momordicae also, with Fructus Momordicae a little, pour boiled water and soak, be a kind of fabulous refreshment drink, both can refresh oneself and promote the production of body fluid, can prevent respiratory tract infection again, take throughout the year, can life lengthening.Fructus Momordicae is described as " angle fruit " by people.Fructus Momordicae originates in the torrid zone, the mountain area, subtropical zone that economize in Guangxi of China, Guangdong, Hainan, Hunan, Jiangxi etc., belongs to Cucurbitaceae liana deciduous plant.Fruits nutrition is worth very high, contains abundant Vitamin C, protein and aminoacid.The Fructus Momordicae sweet in the mouth is cool in nature, lung moistening, heat clearing away are arranged, relieve summer heat, promote the production of body fluid, the effect of cough-relieving.The main effect of Fructus Momordicae is an eliminating phlegm and stopping cough; Can be used for cold cough with Cortex Mori, the Radix Stemonae, batch cough syrup that leaf, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, citric acid etc. are made; Simultaneously can also treat respiratory inflammation: as acute and chronic tonsillitis, acute and chronic friendship tracheitis, pharyngolaryngitis etc.Except above-mentioned effect, modern medicine study proves that Fructus Momordicae also has the effect of the hypertension of preventing and treating, hyperlipidemia and obesity, contains abundant glucoside in the Fructus Momordicae, has hypoglycemic activity, but adjuvant therapy of diabetes and obesity.Therefore simultaneously, Fructus Momordicae dry fruit total sugar content 25.17-38.31% particularly contain the sweet glycoside sweeter 300 times than cane suger, but it does not produce heat, is fit to suffer from diabetes, the edible for patients of disease such as obesity.
Modern pharmacology studies show that Fructus Lycii and Rhizoma Polygonati have enhance immunity, blood sugar lowering and multiple pharmacological effect such as blood fat, slow down aging." Shengji Zonglu " cloud: " informal dress Fructus Lycii and Rhizoma Polygonati can help the gas-solid essence, mend and fill out the public region, invigorate blood circulation and preserve youthful looks, and Chang Sheng is not old." in order to reach best effect, Fructus Lycii or its extract should be identical with Rhizoma Polygonati or its extract consumption.
Mentholum and oil of Rhizoma Zingiberis Recens are the natural aromatic agent, have the effect of refreshing oneself.
As another embodiment of the invention, described principal agent also comprises following one or more parts by weight of component: wolfberry fruit extract 0.2-5 part, Rhizoma Polygonati extract 0.2-5 part, soybean extract 0.2-5 part, Fructus Chaenomelis extract 0.2-3 part, Radix Glycyrrhizae extract 0.1-2 part, oil of Rhizoma Zingiberis Recens 0.1-2 part, Oleum cinnamomi japonici 0.1-2 part and Fructus Citri Limoniae oil 0.1-2 part.
Modern pharmacology studies show that lycium barbarum polysaccharide and polygonatum polysaccharide have effects such as immune stimulating, immunostimulant, slow down aging and have very similar pharmacological effect.These two compatibility will play an effect of complementing each other, promoting each other.The isoflavone that is rich in the Semen sojae atricolor is natural phytoestrogen, has the various biological effect.Epidemiological study, body is interior, experiment in vitro shows that soybean isoflavone has important function to the prevention and the treatment of women's osteoporosis, menopausal syndrome etc.Fructus Chaenomelis has the effect of strengthening the spleen to promote digestion.Papain in the Fructus Chaenomelis can be a fatty acid with steatolysis.Contain a kind of ferment in the Fructus Chaenomelis, the energy digesting protein helps human body food is digested and absorbs.
Radix Glycyrrhizae of the present invention, Oleum cinnamomi japonici and Fructus Citri Limoniae oil and Mentholum and oil of Rhizoma Zingiberis Recens are the natural aromatic agent.Aromatic used in the present invention is not limited to the natural aromatic agent, also can use artificial synthetic aromatic, and employed natural aromatic agent simultaneously also is not limited to above-mentioned several.The present invention can also select for use in Oleum Anisi Stellati, Oleum Rosae Rugosae, rose essence, Fructus Citri Limoniae essence, vanilla, vanillin, flavoring banana essence, flavoring pineapple essence, orange peel oil and the apple essence one or more as aromatic.
Use for the ease of consumer, improve the degree of recognition of described compound extract, the present invention also provides a kind of pressed candy of Sugarless type refreshing, pharynx-clearing and throat-smoothing.Described confection is made up of as principal agent and acceptable accessories described compound extract.
A kind of embodiment as confection of the present invention, calculate by weight, described confection comprises following component: Folium Camelliae sinensis extract 0.2-5 part, GUANALA extract 0.5-5 part, Radix Platycodonis extract 0.2-5 part, Semen Sterculiae Lychnophorae extract 0.2-5 part, wolfberry fruit extract 0.2-5 part, Rhizoma Polygonati extract 0.2-5 part, Fructus Momordicae extract 0.2-5 part, soybean extract 0.2-5 part, Fructus Chaenomelis extract 0.2-3 part, Mentholum 0.1-1 part, oil of Rhizoma Zingiberis Recens 0.1-2 part, Oleum cinnamomi japonici 0.1-2 part, Radix Glycyrrhizae extract 0.1-2 part, Fructus Citri Limoniae oil 0.1-2 part, aspartame 0.3-5 part, Sorbitol 30-50 part, xylitol 10-30 part, oligofructose 5-10 part, magnesium stearate 0.1-2 part, Pulvis Talci 0.1-2 part, microcrystalline cellulose 0.1-2 part, maltodextrin 2-10 part.
Wherein aspartame, Sorbitol, xylitol and oligofructose are sweeting agent.Sweeting agent is meant gives food or the medicine additive with sweet taste, and the sweeting agent that allows in the world at present to use has 20 kinds approximately.Ideal sweeting agent should possess following characteristics: 1. very high safety; 2. the good sense of taste; 3. advantages of higher stability; 4. better water solubility; 5. lower price.So long as the sweeting agent of sugar-free low-calorie all can use in the present invention.Sweeting agent used in the present invention is not limited to above-mentioned several, and the sweeting agent that every permission is used all can use in the present invention.Sweeting agent of the present invention can also be selected one or more in mannitol, maltose alcohol, stevioside, Radix Glycyrrhizae, disodium glycyrrhizinate, trisodium glycyrrhetinate, tripotassium glycyrrhetate, Rhizoma Marantae arundinaceae glucin, glucide, saccharin sodium, sodium cyclamate, L-aspartyl-L-phenylalanine Methylester, acesulfame potassium and the sucralose for use.
Wherein magnesium stearate, Pulvis Talci, microcrystalline cellulose and maltodextrin are acceptable accessories.Acceptable accessories used in the present invention is not limited to above-mentioned several.Acceptable accessories of the present invention can also be selected from one or more in calcium stearate, hydrogenated vegetable oil, micropowder silica gel, Polyethylene Glycol, Stepanol MG, sodium lauryl sulphate, calcium sulfate, calcium phosphate, calcium carbonate, light magnesium oxide, kaolin, aluminium hydroxide desiccant gel, basic magnesium carbonate, sodium chloride, methylcellulose, hydroxypropyl cellulose, ethyl cellulose and the polyvidone.
Another kind of embodiment as confection of the present invention, count by weight percentage, described confection comprises following component: Folium Camelliae sinensis extract 0.1%-0.3%, Radix Platycodonis extract 0.2%-0.8%, Semen Sterculiae Lychnophorae extract 0.1%-0.3%, wolfberry fruit extract 0.1%-0.4%, Rhizoma Polygonati extract 0.1%-0.4%, Fructus Momordicae extract 0.1%-0.3%, oil of Rhizoma Zingiberis Recens clathrate 2%-8%, aspartame 0.5-1.5%, xylitol 71.9%-85%, microcrystalline Cellulose 0.2%-0.8%, magnesium stearate 1%-5%, Mentholum clathrate 5%-10%, Mentholum 0.1%-0.3%.Wherein said oil of Rhizoma Zingiberis Recens clathrate and Mentholum clathrate are meant Benexate Hydrochloride.Preferred as this embodiment, described confection is counted by weight percentage, and comprises following component: Folium Camelliae sinensis extract 0.2%, Radix Platycodonis extract 0.5%, Semen Sterculiae Lychnophorae extract 0.2%, wolfberry fruit extract 0.25%, Rhizoma Polygonati extract 0.25%, Fructus Momordicae extract 0.2%, oil of Rhizoma Zingiberis Recens clathrate 5%, aspartame 0.75%, xylitol 80.95%, microcrystalline cellulose 0.5%, magnesium stearate 3%, Mentholum clathrate 8%, Mentholum 0.2%.
In order to make described composite extract and pressed candy reach better prevention and therapeutic effect, described Folium Camelliae sinensis extract preferably contains the Folium Camelliae sinensis extract of tea polyphenols more than 50%, most preferably contains the Folium Camelliae sinensis extract of tea polyphenols more than 80%.
The preparation technology of described Folium Camelliae sinensis extract is: tea raw material → pure water extracts (70 ℃-90 ℃, preferred 80 ℃～85 ℃) → filtration → extraction feed liquid → cooling → macroporous resin upper prop absorption → adding pure water eluting impurity → adding 10%-30% ethanol elution (preferably adding 25% ethanol elution) → adding 60%-80% ethanol elution (preferably adding 75% ethanol elution) → collection 60%-80% ethanol (preferred 75% ethanol) eluent, secondary filter → concentrate, low-temperature reduced-pressure reclaims solvent → pasteurization → feed liquid cooling → spray drying, gets Folium Camelliae sinensis extract.In this preparation technology, adding the 10%-30% ethanol elution is in order to remove bitterness type catechin, to improve mouthfeel; Adding the 60%-80% ethanol elution is for the eluting tea polyphenols.Therefore, the water extract of the preferred tea of Folium Camelliae sinensis extract of the present invention is through the purification thing at macroporous adsorbent resin separated and collected 60%-80% ethanol elution position, further the purification thing at preferred 75% ethanol elution position.
The preparation technology of described Semen Sterculiae Lychnophorae extract is: it is 40 orders that exsiccant Semen Sterculiae Lychnophorae is pulverized, and takes by weighing powder and puts defat in the fatty extraction device, adds petroleum ether, two backflow defats under 60 ℃ of-95 ℃ of conditions; Volatilize solvent, add 60%-85% ethanol (preferred 70%-80% ethanol) reflux, extract, 2 times under 60 ℃ of-95 ℃ of conditions; After volatilizing ethanol, carry out microwave heating treatment according to different microwave action power, microwave treatment time and different feed liquid ratio.For example: at first add water and leave standstill 5min with the moistening material, microwave radiation extraction 1min handles 1min behind the 3min at interval again, and radiation treatment reaches setting until microwave treatment total time so at interval.With extracting liquid filtering, repeat to extract 1 time by similarity condition, merge extractive liquid, is used the rotary evaporator vacuum concentration, gets Semen Sterculiae Lychnophorae extract.
GUANALA extract of the present invention, Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, soybean extract, Fructus Chaenomelis extract, Fructus Momordicae extract or Radix Glycyrrhizae extract, it is respectively the extract that makes through water extraction by corresponding medicinal raw material, wherein said extraction can be that each medical material extracts respectively, and perhaps also can be that each medical material is mixed extracts together.
In order to estimate the effect of described pressed candy, according to Ministry of Public Health " the health food function assessment assessment process and the method for inspection ", with reference to Ministry of Public Health " new Chinese medicine clinical research guideline ", alleviating physical fatigue animal experiment and pharynx-clearing and throat-smoothing action human feeding trial have been made.
1, alleviating physical fatigue animal experiment
Experiment one, pressed candy are to the influence of mice swimming with a load attached to the body time
(1) animal: 40 of SD rats, body weight 200～300g.
(2) method: 40 rats are divided into 4 groups (n=10) by the table of random number method, and one group is matched group, and its excess-three group is the pressed candy intervention group.Matched group is not fed pressed candy (blank), and the pressed candy intervention group is fed the pressed candy of 0.05g/kg, 0.25g/kg, 0.75g/kg various dose.After feeding for 2 weeks, these four groups of rats are born the weight identical with its body weight one by one, put into the pond, measure swimming with a load attached to the body time of each rat with stopwatch, and the gained data are added up, the result is as shown in table 1.
Table 1 pressed candy is to the influence of mice swimming with a load attached to the body time
Experiment two, pressed candy are to the influence of Mouse Liver glycogen
(1) animal: 40 of SD rats, body weight 200～300g.
(2) method: 40 rats are divided into 4 groups (n=10) by the table of random number method, and one group is matched group, and its excess-three group is the pressed candy intervention group.Matched group is not fed pressed candy (blank), and the pressed candy intervention group is fed the pressed candy of 0.05g/kg, 0.25g/kg, 0.75g/kg various dose.Feed after 1 month, all fasting 12h of rat elder generation, it is back with after the dosage intraperitoneal injection anesthesia of 20g/L nembutal solution with 1mg/kg to weigh, get the same position 1cm * 1cm of leftlobe of liver * 1cm tissue after opening abdomen, carry out the detection in glycogen source, and the gained data are added up, the result is as shown in table 2.
Table 2 pressed candy is to the influence of Mouse Liver glycogen
Experiment three, pressed candy are to the influence of blood lactate level before and after the mouse movement
(1) animal: 40 of SD rats, body weight 200～300g.
(2) method: 40 rats are divided into 4 groups (n=10) by the table of random number method, and one group is matched group, and its excess-three group is the pressed candy intervention group.Matched group is not fed pressed candy (blank), and the pressed candy intervention group is fed the pressed candy of 0.05g/kg, 0.25g/kg, 0.75g/kg various dose.After feeding for 2 weeks, get the blood sample of each rat, the blood lactic acid value when measuring its peace and quiet.These four groups of rats are born the weight identical with its body weight one by one, put into the pond and swim, 0min and 20min after rats'swimming get the blood sample of each rat respectively, measure its blood lactic acid value, and the gained data are added up, and the result is as shown in table 3.
Table 3 pressed candy is to the influence of blood lactate level before and after the mouse movement
The experimental data explanation, pressed candy can obviously prolong the mice swimming with a load attached to the body time, can reduce mouse movement front and back blood lactic acid area under curve; Can increase sugar deposit in its body after taking pressed candy to mice simultaneously, guarantee that the energy of tissues such as central nervous system, motor and erythrocyte is supplied with, the fatigue of delayed motion takes place, and improves motor capacity.Above experimental data illustrates that this pressed candy has the alleviating physical fatigue function.
2, moistening and cleaning throat crowd test
Own control design, experimenter's voluntary participation are adopted in the function of moistening and cleaning throat test.Instructions of taking: every day 3-8 time, each 1, took continuously 30 days.The experimenter withdraws other medicine with function of moistening and cleaning throat and health product in the test-meal process.Result of the test is shown in table 4 and 5.
Table 4 cardinal symptom is improved situation
The pharyngeal sign of table 5 is improved situation
The result shows, signs such as cardinal symptom such as pressed candy of the present invention is scorching hot to chronic pharyngitis examination trencherman pharyngalgia, itching throat, pharynx, dry cough, polylogia increase the weight of, foreign body in pharynx sense, dry pharynx is puckery, expectoration is not well and pharyngeal congestion, edema, pharynx rear wall follicle hypertrophy all have the improvement effect.
The specific embodiment
Example 1:
Prescription:
1 part of Folium Camelliae sinensis extract, 0.5 part of GUANALA extract, 0.2 part of Radix Platycodonis extract, 0.2 part of Semen Sterculiae Lychnophorae extract, 0.2 part of wolfberry fruit extract, 0.2 part of Rhizoma Polygonati extract, 0.2 part of Fructus Momordicae extract, 0.1 part of oil of Rhizoma Zingiberis Recens, 0.1 part of Mentholum.
Preparation process:
1. Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, Fructus Momordicae extract and GUANALA extract all adopt the preparation of water concentration compression method, and the technological parameter of each water concentration compression method is identical.
With the Rhizoma Polygonati extract is example: get the Rhizoma Polygonati medical material that meets the Chinese Pharmacopoeia requirement, clean, chop up, the water that adds 8 times of amounts boils and extracts twice, each 2 hour, 100 orders filter, merge filtrate twice, 60 ℃ are evaporated to relative density is 1.25～1.30, (50 ℃ of microwave vacuum dryings,-0.08MPa), pulverize, cross 100 mesh sieves, promptly.
2. the preparation technology of Semen Sterculiae Lychnophorae extract: it is 40 orders that exsiccant Semen Sterculiae Lychnophorae is pulverized, and takes by weighing powder and puts defat in the fatty extraction device, adds petroleum ether, 90 ℃ of two backflow defat; Volatilize solvent, add 90 ℃ of reflux, extract, of 80% ethanol 2 times; After volatilizing ethanol, carry out microwave heating treatment according to different microwave action power, microwave treatment time and different feed liquid ratio.At first add water and leave standstill 5min with the moistening material, microwave radiation extraction 1min handles 1min behind the 3min at interval again, and radiation treatment was until 1 hour microwave treatment total time so at interval.With extracting liquid filtering, repeat to extract 1 time by similarity condition, merge extractive liquid, is used the rotary evaporator vacuum concentration, microwave drying (50 ℃ ,-0.08MPa), pulverized 100 mesh sieves, get Semen Sterculiae Lychnophorae extract.
3. Folium Camelliae sinensis extract technology: tea raw material with pure water 80～85 ℃ extract 2 this, each 2 hours, 100 orders filtered.Merge filtrate twice, put cold back and cross macroporous resin column, add pure water, 10% ethanol elution impurity successively.At the ethanol elution that adds 60%, collect 60% ethanol elution, 50 ℃ of decompression recycling ethanols, pasteurization, spray drying is crossed 100 mesh sieves promptly.
4. take by weighing various materials according to formula ratio,, promptly get described compound extract with refreshing, pharynx-clearing and throat-smoothing action with the abundant mix homogeneously of the material that takes by weighing.
Embodiment 2
Prescription:
5 parts of Folium Camelliae sinensis extracts, 5 parts of GUANALA extracts, 5 parts of Radix Platycodonis extracts, 5 parts of Semen Sterculiae Lychnophorae extracts, 5 parts of wolfberry fruit extracts, 5 parts of Rhizoma Polygonati extracts, 5 parts of Fructus Momordicae extracts, 2 parts of oil of Rhizoma Zingiberis Recens, 1 part of Mentholum.Preparation process:
1. the preparation technology of Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, Fructus Momordicae extract and GUANALA extract is with embodiment 1.
2. the preparation technology of Semen Sterculiae Lychnophorae extract: it is 40 orders that exsiccant Semen Sterculiae Lychnophorae is pulverized, and takes by weighing powder and puts defat in the fatty extraction device, adds petroleum ether, 60 ℃ of two backflow defat; Volatilize solvent, add 60 ℃ of reflux, extract, of 60% ethanol 2 times; After volatilizing ethanol, carry out microwave heating treatment according to different microwave action power, microwave treatment time and different feed liquid ratio.At first add water and leave standstill 5min with the moistening material, microwave radiation extraction 1min handles 1min behind the 3min at interval again, and radiation treatment reaches setting until microwave treatment total time so at interval.With extracting liquid filtering, repeat to extract 1 time by similarity condition, merge extractive liquid, is used the rotary evaporator vacuum concentration, microwave drying (50 ℃ ,-0.08MPa), pulverized 100 mesh sieves, get Semen Sterculiae Lychnophorae extract.
3. Folium Camelliae sinensis extract technology: tea raw material with pure water 70 ℃ extract 2 this, each 2 hours, 100 orders filtered.Merge filtrate twice, put cold back and cross macroporous resin column, add pure water, 30% ethanol elution impurity successively.At the ethanol elution that adds 80%, collect 80% ethanol elution, 50 ℃ of decompression recycling ethanols, pasteurization, spray drying is crossed 100 mesh sieves promptly.
4. take by weighing various materials according to formula ratio,, promptly get described compound extract with refreshing, pharynx-clearing and throat-smoothing action with the abundant mix homogeneously of the material that takes by weighing.
Embodiment 3
Prescription:
3 parts of Folium Camelliae sinensis extracts, 3 parts of GUANALA extracts, 3 parts of Radix Platycodonis extracts, 3 parts of Semen Sterculiae Lychnophorae extracts, 3 parts of wolfberry fruit extracts, 3 parts of Rhizoma Polygonati extracts, 3 parts of Fructus Momordicae extracts, 1 part of oil of Rhizoma Zingiberis Recens, 0.5 part of Mentholum.Preparation process:
1. the preparation technology of Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, Fructus Momordicae extract and GUANALA extract is with embodiment 1.
2. the preparation technology of Semen Sterculiae Lychnophorae extract: it is 40 orders that exsiccant Semen Sterculiae Lychnophorae is pulverized, and takes by weighing powder and puts defat in the fatty extraction device, adds petroleum ether, 95 ℃ of two backflow defat; Volatilize solvent, add 60 ℃ of reflux, extract, of 70% ethanol 2 times; After volatilizing ethanol, carry out microwave heating treatment according to different microwave action power, microwave treatment time and different feed liquid ratio.At first add water and leave standstill 5min with the moistening material, microwave radiation extraction 1min handles 1min behind the 3min at interval again, and radiation treatment reaches setting until microwave treatment total time so at interval.With extracting liquid filtering, repeat to extract 1 time by similarity condition, merge extractive liquid, is used the rotary evaporator vacuum concentration, microwave drying (50 ℃ ,-0.08MPa), pulverized 100 mesh sieves, get Semen Sterculiae Lychnophorae extract.
3. Folium Camelliae sinensis extract technology: tea raw material with pure water 90 ℃ extract 2 this, each 2 hours, 100 orders filtered.Merge filtrate twice, put cold back and cross macroporous resin column, add pure water, 25% ethanol elution impurity successively.At the ethanol elution that adds 75%, collect 75% ethanol elution, 50 ℃ of decompression recycling ethanols, pasteurization, spray drying is crossed 100 mesh sieves promptly.
4. take by weighing various materials according to formula ratio,, promptly get described compound extract with refreshing, pharynx-clearing and throat-smoothing action with the abundant mix homogeneously of the material that takes by weighing.
Embodiment 4
Prescription:
Folium Camelliae sinensis extract 0.1%, Radix Platycodonis extract 0.2%, Semen Sterculiae Lychnophorae extract 0.1%, wolfberry fruit extract 0.4%, Rhizoma Polygonati extract 0.4%, Fructus Momordicae extract 0.3%, oil of Rhizoma Zingiberis Recens clathrate 2%, aspartame 0.5%, xylitol 80.5%, microcrystalline Cellulose 0.2%, magnesium stearate 5%, Mentholum clathrate 10%, Mentholum 0.3%.
Preparation process:
1. Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, Fructus Momordicae extract, Semen Sterculiae Lychnophorae extract and green tea extract preparation technology are with embodiment 1.
2. the oil of Rhizoma Zingiberis Recens clathrate is identical with the preparation technology of Mentholum clathrate.For example, it is some to get the Mentholum crystal, adds an amount of 95% ethanol and makes it to dissolve fully, standby.Take by weighing the beta-schardinger dextrin-of 8 times of Mentholum weight, add the water of 3 times of beta-schardinger dextrin-weight, stir with mortar.Slowly drip the alcoholic solution of Mentholum on one side, grind on one side, after dropwising, continue to grind 30 minutes.Sucking filtration, and with an amount of alcohol flushing filter cake.Filter cake 30 ℃ of oven dry down, is pulverized, crossed 100 mesh sieves promptly.
3. take by weighing various materials according to formula ratio, wherein Mentholum, Mentholum clathrate, magnesium stearate three's uniform mixing are standby.Unclassified stores is fully mixed, add the alcoholic acid ratio of 20ml95% according to the every 100g of formula ratio and add 95% ethanol, stir; Granulate with 20 mesh sieves; Under 55 ℃, be baked to below the moisture content to 1%.20 mesh sieve granulate add Mentholum, Mentholum clathrate, magnesium stearate three's mixture, mix 40min, tabletting.
Embodiment 5
Prescription:
Folium Camelliae sinensis extract 0.3%, Radix Platycodonis extract 0.8%, Semen Sterculiae Lychnophorae extract 0.3%, wolfberry fruit extract 0.1%, Rhizoma Polygonati extract 0.1%, Fructus Momordicae extract 0.1%, oil of Rhizoma Zingiberis Recens clathrate 8%, aspartame 1.5%, xylitol 81.9%, microcrystalline Cellulose 0.8%, magnesium stearate 1%, Mentholum clathrate 5%, Mentholum 0.1%.Preparation process:
1. Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, Fructus Momordicae extract, Semen Sterculiae Lychnophorae extract and green tea extract preparation technology are with embodiment 2.
2. the preparation technology of oil of Rhizoma Zingiberis Recens clathrate and Mentholum clathrate is with embodiment 4.
3. take by weighing various materials according to formula ratio, wherein Mentholum, Mentholum clathrate, magnesium stearate three's uniform mixing are standby.Unclassified stores is fully mixed, add the alcoholic acid ratio of 20ml95% according to the every 100g of formula ratio and add 95% ethanol, stir; Granulate with 20 mesh sieves; Under 55 ℃, be baked to below the moisture content to 1%.20 mesh sieve granulate add Mentholum, Mentholum clathrate, magnesium stearate three's mixture, mix 40min, tabletting.
Embodiment 6
Prescription:
Folium Camelliae sinensis extract 0.2%, Radix Platycodonis extract 0.5%, Semen Sterculiae Lychnophorae extract 0.2%, wolfberry fruit extract 0.25%, Rhizoma Polygonati extract 0.25%, Fructus Momordicae extract 0.2%, oil of Rhizoma Zingiberis Recens clathrate 5%, aspartame 0.75%, xylitol 80.95%, microcrystalline cellulose 0.5%, magnesium stearate 3%, Mentholum clathrate 8%, Mentholum 0.2%.
Preparation process:
1. Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, Fructus Momordicae extract, Semen Sterculiae Lychnophorae extract and green tea extract preparation technology are with embodiment 3.
2. the preparation technology of oil of Rhizoma Zingiberis Recens clathrate and Mentholum clathrate is with embodiment 4.
3. take by weighing various materials according to formula ratio, wherein Mentholum, Mentholum clathrate, magnesium stearate three's uniform mixing are standby.Unclassified stores is fully mixed, add the alcoholic acid ratio of 20ml95% according to the every 100g of formula ratio and add 95% ethanol, stir; Granulate with 20 mesh sieves; Under 55 ℃, be baked to below the moisture content to 1%.20 mesh sieve granulate add Mentholum, Mentholum clathrate, magnesium stearate three's mixture, mix 40min, tabletting.
Embodiment 7
Prescription:
Folium Camelliae sinensis extract 0.3%, Radix Platycodonis extract 0.8%, Semen Sterculiae Lychnophorae extract 0.3%, wolfberry fruit extract 0.4%, Rhizoma Polygonati extract 0.4%, Fructus Momordicae extract 0.3%, oil of Rhizoma Zingiberis Recens clathrate 8%, aspartame 1.5%, xylitol 71.9%, microcrystalline Cellulose 0.8%, magnesium stearate 5%, Mentholum clathrate 10%, Mentholum 0.3%.Preparation process: with embodiment 6.
Embodiment 8
Prescription:
Folium Camelliae sinensis extract 0.1%, Radix Platycodonis extract 0.2%, Semen Sterculiae Lychnophorae extract 0.1%, wolfberry fruit extract 0.1%, Rhizoma Polygonati extract 0.1%, Fructus Momordicae extract 0.1%, oil of Rhizoma Zingiberis Recens clathrate 5%, aspartame 0.5%, xylitol 85%, microcrystalline Cellulose 0.2%, magnesium stearate 2%, Mentholum clathrate 6.5%, Mentholum 0.1%. preparation process: with embodiment 6.
Embodiment 9
Prescription:
Folium Camelliae sinensis extract (polyphenol content 80%) 0.2%, Radix Platycodonis extract 0.5%, Semen Sterculiae Lychnophorae extract 0.2%, wolfberry fruit extract 0.25%, Rhizoma Polygonati extract 0.25%, Fructus Momordicae extract 0.2%, oil of Rhizoma Zingiberis Recens clathrate 5%, aspartame 0.75%, xylitol 80.95%, microcrystalline cellulose 0.5%, magnesium stearate 3%, Mentholum clathrate 8%, Mentholum 0.2%.
Preparation process: with embodiment 6.
Embodiment 10
Prescription:
0.2 part of Folium Camelliae sinensis extract, 0.5 part of GUANALA extract, 0.2 part of Radix Platycodonis extract, 0.2 part of Semen Sterculiae Lychnophorae extract, 0.2 part of wolfberry fruit extract, 0.2 part of Rhizoma Polygonati extract, 0.2 part of Fructus Momordicae extract, 0.2 part of soybean extract, 0.2 part of Fructus Chaenomelis extract, 0.1 part of Mentholum, 0.1 part of oil of Rhizoma Zingiberis Recens, 0.1 part of Oleum cinnamomi japonici, 0.1 part of Radix Glycyrrhizae extract, 0.1 part of Fructus Citri Limoniae oil, 0.3 part of aspartame, 30 parts of Sorbitols, 10 parts of xylitol, 5 parts of oligofructoses, 0.1 part of magnesium stearate, 0.1 part of Pulvis Talci, 0.1 part of microcrystalline cellulose, 2 parts of maltodextrins.
Preparation process:
1. the same Rhizoma Polygonati extract of the preparation technology of GUANALA extract, soybean extract, Fructus Chaenomelis extract and Radix Glycyrrhizae extract.
2. the preparation technology of Folium Camelliae sinensis extract, Radix Platycodonis extract, Semen Sterculiae Lychnophorae extract, wolfberry fruit extract, Rhizoma Polygonati extract and Fructus Momordicae extract is with embodiment 3.
3. take by weighing various materials according to formula ratio, wherein Mentholum and magnesium stearate uniform mixing are standby.Unclassified stores is fully mixed, add the alcoholic acid ratio of 20ml95% according to the every 100g of formula ratio and add 95% ethanol, stir; Granulate with 20 mesh sieves; Under 55 ℃, be baked to below the moisture content to 1%.20 mesh sieve granulate, the mixture of adding Mentholum and magnesium stearate mixes 40min, tabletting.
Embodiment 11
Prescription:
5 parts of Folium Camelliae sinensis extracts, 5 parts of GUANALA extracts, 5 parts of Radix Platycodonis extracts, 5 parts of Semen Sterculiae Lychnophorae extracts, 5 parts of wolfberry fruit extracts, 5 parts of Rhizoma Polygonati extracts, 5 parts of Fructus Momordicae extracts, 5 parts of soybean extract, 3 parts of Fructus Chaenomelis extract, 1 part of Mentholum, 2 parts of oil of Rhizoma Zingiberis Recens, 2 parts of Oleum cinnamomi japonicis, 2 parts of Radix Glycyrrhizae extracts, 2 parts of Fructus Citri Limoniae oil, 5 parts of aspartames, 50 parts of Sorbitols, 30 parts of xylitol, 10 parts of oligofructoses, 2 parts of magnesium stearate, 2 parts of Pulvis Talci, 2 parts of microcrystalline celluloses, 10 parts of maltodextrins.
Preparation process: with embodiment 10
Embodiment 12
Prescription:
3 parts of Folium Camelliae sinensis extracts, 3 parts of GUANALA extracts, 3 parts of Radix Platycodonis extracts, 3 parts of Semen Sterculiae Lychnophorae extracts, 3 parts of wolfberry fruit extracts, 3 parts of Rhizoma Polygonati extracts, 2 parts of Fructus Momordicae extracts, 2 parts of soybean extract, 2 parts of Fructus Chaenomelis extract, 0.5 part of Mentholum, 1 part of oil of Rhizoma Zingiberis Recens, 1 part of Oleum cinnamomi japonici, 1.5 parts of Radix Glycyrrhizae extracts, 1.5 parts of Fructus Citri Limoniae oil, 2 parts of aspartames, 40 parts of Sorbitols, 20 parts of xylitol, 7 parts of oligofructoses, 1 part of magnesium stearate, 1.5 parts of Pulvis Talci, 1.5 parts of microcrystalline celluloses, 6 parts of maltodextrins.
Preparation process: with embodiment 10.
Claims (10)
1, a kind of compound extract with refreshing, pharynx-clearing and throat-smoothing action is characterized in that principal agent comprises the component of following weight portion: Folium Camelliae sinensis extract 1-5 part, GUANALA extract 0.5-5 part, Radix Platycodonis extract 0.2-5 part, Semen Sterculiae Lychnophorae extract 0.2-5 part, Fructus Momordicae extract 0.2-5 part, xylitol 10-60 part, Mentholum 0.1-1 part.
2, compound extract according to claim 1, wherein, described principal agent also comprises following one or more parts by weight of component: wolfberry fruit extract 0.2-5 part, Rhizoma Polygonati extract 0.2-5 part, soybean extract 0.2-5 part, Fructus Chaenomelis extract 0.2-3 part, Radix Glycyrrhizae extract 0.1-2 part, oil of Rhizoma Zingiberis Recens 0.1-2 part, Oleum cinnamomi japonici 0.1-2 part and Fructus Citri Limoniae oil 0.1-2 part.
3, a kind of pressed candy of Sugarless type refreshing, pharynx-clearing and throat-smoothing is characterized in that being made up of as principal agent and acceptable accessories claim 1 or 2 described compound extracts.
4, pressed candy according to claim 3, calculate by weight, comprise following component: Folium Camelliae sinensis extract 0.2-5 part, GUANALA extract 0.5-5 part, Radix Platycodonis extract 0.2-5 part, Semen Sterculiae Lychnophorae extract 0.2-5 part, wolfberry fruit extract 0.2-5 part, Rhizoma Polygonati extract 0.2-5 part, Fructus Momordicae extract 0.2-5 part, soybean extract 0.2-5 part, Fructus Chaenomelis extract 0.2-3 part, Mentholum 0.1-1 part, oil of Rhizoma Zingiberis Recens 0.1-2 part, Oleum cinnamomi japonici 0.1-2 part, Radix Glycyrrhizae extract 0.1-2 part, Fructus Citri Limoniae oil 0.1-2 part, aspartame 0.3-5 part, Sorbitol 30-50 part, xylitol 10-30 part, oligofructose 5-10 part, magnesium stearate 0.1-2 part, Pulvis Talci 0.1-2 part, microcrystalline cellulose 0.1-2 part, maltodextrin 2-10 part.
5, pressed candy according to claim 3, count by weight percentage, comprise following component: Folium Camelliae sinensis extract 0.1%-0.3%, Radix Platycodonis extract 0.2%-0.8%, Semen Sterculiae Lychnophorae extract 0.1%-0.3%, wolfberry fruit extract 0.1%-0.4%, Rhizoma Polygonati extract 0.1%-0.4%, Fructus Momordicae extract 0.1%-0.3%, oil of Rhizoma Zingiberis Recens clathrate 2%-8%, aspartame 0.5-1.5%, xylitol 71.9%-85%, microcrystalline Cellulose 0.2%-0.8%, magnesium stearate 1%-5%, Mentholum clathrate 5%-10%, Mentholum 0.1%-0.3%.
6, pressed candy according to claim 5 is counted by weight percentage, and comprises following component: Folium Camelliae sinensis extract 0.2%, Radix Platycodonis extract 0.5%, Semen Sterculiae Lychnophorae extract 0.2%, wolfberry fruit extract 0.25%, Rhizoma Polygonati extract 0.25%, Fructus Momordicae extract 0.2%, oil of Rhizoma Zingiberis Recens clathrate 5%, aspartame 0.75%, xylitol 80.95%, microcrystalline cellulose 0.5%, magnesium stearate 3%, Mentholum clathrate 8%, Mentholum 0.2%.
7, according to claim 5 or 6 described pressed candies, wherein said clathrate is meant Benexate Hydrochloride.
8, according to the described pressed candy of claim 1-7, wherein, described Folium Camelliae sinensis extract for contain tea polyphenols more than 50% (preferred more than 80%) remove the bitterness green tea extract; Preferred described Folium Camelliae sinensis extract is the purification thing of green tea water extract through macroporous adsorbent resin separated and collected 60%-80% ethanol elution position.
9, according to the described pressed candy of claim 1-8, wherein, described Semen Sterculiae Lychnophorae extract is by using 60%-85% ethanol, preferred 70%-80% ethanol extraction, the extract of extract gained after microwave treatment after the defat of Semen Sterculiae Lychnophorae raw material.
10, according to the described pressed candy of claim 1-9, wherein, described GUANALA extract, Radix Platycodonis extract, wolfberry fruit extract, Rhizoma Polygonati extract, soybean extract, Fructus Chaenomelis extract, Fructus Momordicae extract or Radix Glycyrrhizae extract, it is respectively the extract that makes through water extraction by corresponding medicinal raw material, wherein said extraction can be that each medical material extracts respectively, and perhaps also can be that each medical material is mixed extracts together.
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