CN101991773B - Loquat extract extracted from loquat pulp and preparation method thereof - Google Patents
Loquat extract extracted from loquat pulp and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a loquat extract extracted from loquat pulp and a preparation method thereof. The loquat extract is prepared from the following ingredients in percent by weight: 200 to 400 parts of loquat, 6 to 10 parts of radix glehniae, 5 to 9 parts of coltsfoot, 8 to 12 parts of fritillaria cirrhosa fluid extract, 5 to 9 parts of polygonatum, 6 to 10 parts of Chinese violet, 4 to 8 parts of ilex rotunda, 5 to 9 parts of lily, 5 to 9 parts of dried orange peel, 5 to 9 parts of tuber pinellia, 4 to 8 parts of cortex magnoliae officinalis, 6 to 10 parts of perilla-seed, 3 to 7 parts of liquorice and 4 to 8 parts of radix codonopsitis. The preparation method comprises the following steps of: preparing the fritillaria cirrhosa fluid extract; preparing Chinese medicine extracts; crushing the obtained loquat pulp through a crushing machine; adding the loquat pulp and the white granulated sugar into the obtained Chinese medicine thick paste; boiling the materials for 2 hours; filtering the materials; mixing and uniformly stirring filter liquid with 8 to 12 parts of the obtained fritillaria cirrhosa fluid extract; concentrating the filter liquid to a relative density between 1.25 and 1.40 at 60 DEG C; standing and cooling the materials to 55 DEG C; adding menthol; adding water to a specified quantity; and uniformly stirring the materials to obtain the loquat extract.
Description
Technical field:
The invention belongs to health product and field of medicaments, especially belong to a kind of loquat extract extracted from loquat pulp that adopts traditional Chinese medicine one-tenth and preparation method thereof.
Background technology:
Folium Eriobotryae is different from most of fruit tree, in autumn or open early winter luxuriant, fruit is ripe in spring to early summer, all more Zao than other fruit, therefore claimed to be solely standby seasonal pathogens,exopathogens person in the fruit tree, ripe Folium Eriobotryae fruit is that bunchy is hung in the tree, ripe Folium Eriobotryae taste is pretty good, nutrition is rich, various fructose, glucose, potassium, phosphorus, ferrum, calcium and vitamin A, B, C etc. are arranged, leaf and fruit is used as medicine, and the effects such as heat clearing away, lung moistening, relieving cough and resolving phlegm are arranged, and the traditional Chinese medical science is thought the function that loquat has lung moistening, cough-relieving, quenches the thirst.
Having at present the existing many reports of medicine of nourishing YIN and moistening the lung and eliminating phlegm and stopping cough, is 2008100724915 such as application number, and its prescription is: Flos Eriobotryae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis and Semen Armeniacae Amarum, generally all use Folium Eriobotryae, Flos Eriobotryae etc. in the prescription, and seldom see the employing Fractus Eriobotryae; And the Chinese crude drug composition is also less in the described prescription, and these have all restricted as treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to the stagnation of fire in the interior, laryngopharynx swelling and pain, breast distending pain, the effect of the symptoms such as cold cough and chronic bronchitis.
Summary of the invention:
The object of the present invention is to provide a kind of cough eliminated symptom that several kinds of Chinese medicinal materials and Fractus Eriobotryae be mixed with and loquat extract extracted from loquat pulp of healing and preparation method thereof of adopting.
The object of the present invention is achieved like this, described a kind of loquat extract extracted from loquat pulp and preparation method thereof, and it is to be made by the raw material of following weight proportioning:
Fractus Eriobotryae 200-400 part, Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Bulbus Fritillariae Cirrhosae fluidextract 8-12 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part.
Optimization formula is: 300 parts of Fractus Eriobotryaes, 8 parts of Radix Glehniaes, 7 parts of Flos Farfaraes, 10 parts of Bulbus Fritillariae Cirrhosae fluidextracts, 7 parts of Rhizoma Polygonati Odorati, 8 parts of Herba Violaes, 6 parts of Ilex rotunda Thunb.s, 7 parts of Bulbus Liliies, 7 parts of Pericarpium Citri Reticulataes, 7 parts of the Rhizoma Pinelliaes, 6 parts of Cortex Magnoliae Officinalis, 8 parts of Fructus Perillaes, 5 parts in Radix Glycyrrhizae, 6 parts of Radix Codonopsis.
The preparation method of Bulbus Fritillariae Cirrhosae fluidextract is as follows: following % is weight percentage.
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, ooze method according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, and device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, adds the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1～1.2 thick paste.
The present inventor studies intensively and continuously clinical verification through two more than ten years, and this loquat leaf extract has the treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to the stagnation of fire in the interior, laryngopharynx swelling and pain, breast distending pain, the symptoms such as cold cough and chronic bronchitis.In the prescription 1) Fractus Eriobotryae: [performance] sweet in the mouth, little acid, cool in nature.The energy nourishing the lung to arrest cough, promoting the production of body fluid to quench thirst, regulating the stomach and sending down the abnormal ascending QI.[reference] sarcocarp is sugary, protein, fat, pectin, carotene, vitamin B1, C, the compositions such as tartaric acid, malic acid, citric acid.[purposes] is used for lung-dryness syndrome due to deficiency of YIN, cough, or spitting of blood; Deficiency of stomach-Yin, dry throat and mouth, or QI failing to descend, retch loss of appetite.[usage] eaten raw, endures cream, or fries in shallow oil soup.2) Radix Glehniae, [function cures mainly] nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Be used for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound thirsty.3) Flos Farfarae, function with cure mainly: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Be used for new chronic cough and cough dyspnea and cough with excessive sputum, chronic cough hemoptysis.4) Bulbus Fritillariae Cirrhosae, [function cures mainly] clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Control cough due to consumptive disease, the spitting of blood of spitting, ambition Yu Jie, consumptive lung disease, lung abscess, sore throat, acute mastitis; 5) Rhizoma Polygonati Odorati, nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain; 6) Herba Violae, function cures mainly: can be used as medicine its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood detumescence.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.7) Ilex rotunda Thunb., effect: heat-clearing and toxic substances removing; Dampness removing; Pain relieving.Cold, fever; Laryngopharynx swelling and pain; Stomachache; Administration's diarrhea due to damp pathogen rushes down; Jaundice; Dysentery; Traumatic injury; Rheumatic arthralgia; Eczema; Furuncle.8) Bulbus Lilii cures mainly: be used for the xeropulmonary cough, chronic cough of deficiency lung, sputum mixed with blood; Deficiency of YIN chronic cough; Sputum mixed with blood; The calentura later stage; Waste heat is unclear, or fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, the absentminded of feelings will due to unsuccessful; Carbuncle; Eczema; 9) Pericarpium Citri Reticulatae, the merit of appetizing in tool regulating QI and lowering the adverseness, the accent, drying dampness to eliminate phlegm.Cure mainly dirty contrary, the difficulty in urination and defecation of full vexed, the abdominal distention of the wet resistance of stagnation of QI in spleen and stomach, chest and diaphragm, anorexia, vomiting, lung qi retardance, cough with copious phlegm, also control acute mastitis from the beginning of.Through for many years research, existing known Pericarpium Citri Reticulatae has many pharmacological actions.10) Rhizoma Pinelliae, function cures mainly, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Be used for that abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant are dizzy, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass are vexed, globus hystericus disease; Give birth to external treatment carbuncle sucutaneous nodule.11) Cortex Magnoliae Officinalis, [effect] alleviating distention in middle-JIAO is regulated the flow of vital energy, the removing dampness dissipating depression of QI.Deficiency and coldness of spleen and stomach, abdominal part dull pain.12) Fructus Perillae, function cures mainly: the sending down the abnormal ascending QI expectorant, relieving asthma intestine moistening.Be used for expectorant and stop up QI rising in reverse order, cough and asthma, dryness of the intestine constipation.13) Radix Glycyrrhizae, [function cures mainly]: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.14) Radix Codonopsis, Radix Codonopsis has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc." Bencao Congxin " record: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than the middle feeble QI, mend in order to transfer, very smooth and proper.”。Above 14 kinds of medicines share, and clearing heat and moistening lung are arranged, preventing phlegm from forming and stopping coughing, and removing stasis to stop bleeding, the merit of nourishing qi to stop, assistant helps all medicines of the monarch and his subjects to control all diseases of cough, flu altogether.
Can do paste making agent, oral solid formulation or the oral liquid etc. of Chinese medicine preparation of the present invention all can.
The preparation method of loquat extract extracted from loquat pulp of the present invention: Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to (appendix IO of Chinese Pharmacopoeia version in 2000) percolation under fluid extract and the extractum item, makes solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, gets the liquid of filtering and is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1～1.2 Bulbus Fritillariae Cirrhosae thick paste, for subsequent use; The Radix Glehniae, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygonati Odorati, Herba Violae, Ilex rotunda Thunb., Bulbus Lilii, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Perillae, Radix Glycyrrhizae, the Radix Codonopsis that take by weighing in proportion above-mentioned formula ratio decoct with water secondary, boiling temps can reach 120 ℃, 2-3 hour for the first time, 1.5-2.5 hour for the second time, collecting decoction, filter to get filtrate, filtrate is concentrated into relative density is preferably 1.25～1.40 Chinese crude drug thick paste (being as the criterion as 60 ℃ take temperature).The Chinese crude drug thick paste adds Folium Eriobotryae meat, also can add an amount of white sugar, boils 1-3 hour, boiling temps can reach 110 ℃, filters, and filter screen can be 20 purpose filter screens, filtrate and Bulbus Fritillariae Cirrhosae thick paste mix homogeneously, continuing to be concentrated into relative density under 60 ℃ is 1.25～1.40, lets cool, after being cooled to 55 ℃, can add the adjuvant Mentholum, add water to ormal weight, stir evenly, and get final product, bottle, sterilize, seal, be packaged into product.Mentholum can account for the 0.05-0.12% of gross weight.
Above-mentioned Folium Eriobotryae meat is that ripe Folium Eriobotryae is removed skin and pit, uses behind the wash clean to be obtained by broken crusher machine.
Loquat leaf extract of the present invention belongs to the oral type unguentum, adult every day 2～3 times, each soupspoon (approximately 15mL).
According to traditional Chinese medical science traditional theory, the diaphoresis such as the Bulbus Fritillariae Cirrhosae diuretic of relievining asthma, monarch drug in the side of being, relieving cough and reducing sputum; The expectorant cough suppressant and anti-asthmatics such as loquat are ministerial drug in the side; The Radix Codonopsis invigorating the spleen and replenishing QI is adjuvant drug in the side; Pale reddish brown ground T etc. has heat-clearing and toxic substances removing, and the removing heat from blood detumescence reaches the antiinflammatory effect; Radix Glycyrrhizaes etc. are reduced phlegm, and Synergistic is accessory drugs.The present invention not only relieving cough and reducing sputum but also antiinflammatory reach synergistic action effect.The present invention selects unguentum.But also tablet, granule, capsule, soft capsule, drop pill, pill etc.
Because loquat leaf extract of the present invention is take loquat fruit as primary raw material, take Radix Glehniae, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygonati Odorati, Herba Violae, Ilex rotunda Thunb., Bulbus Lilii, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Perillae, Radix Glycyrrhizae, Radix Codonopsis as Chinese crude drug and sucrose as adjuvant, therefore has the function of clearing away lung-heat to relieve cough and stopping nausea and vomiting by lowering the adverse flow of QI, for lung-heat type cough, the few dry pharynx of expectorant, stay up late and tobacco and wine are excessive etc. has a good effect.The function of lung moistening, cough-relieving are arranged, quenching the thirst.In addition, production technology of the present invention is simple, does not have environmental pollution.
Loquat leaf extract of the present invention is the treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to the stagnation of fire in the interior, laryngopharynx swelling and pain, the breast distending pain, the oral syrup class pure Chinese medicinal preparation of the symptom such as cold cough and chronic bronchitis is through for many years clinical verification, steady quality, determined curative effect is the common drug preparation that clinical and family is used for the treatment of above disease.Other similar oral formulations also has the watered pill, tablet etc., and its characteristics are similar, act on basic identical, without significant difference.
The specific embodiment:
The present invention is described in detail below in conjunction with embodiment:
Embodiment 1
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae 50 grams and be ground into coarse powder, ooze method according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1～1.2 thick paste, stand-by.
2) preparation method of Chinese medicine extract:
Radix Glehniae 8 grams, Flos Farfarae 7 grams, Rhizoma Polygonati Odorati 7 grams, Herba Violae 8 grams, Ilex rotunda Thunb. 6 grams, Bulbus Lilii 7 grams, Pericarpium Citri Reticulatae 7 grams, the Rhizoma Pinelliae 7 grams, Cortex Magnoliae Officinalis 6 grams, Fructus Perillae 8 grams, Radix Glycyrrhizae 5 grams, Radix Codonopsis 6 grams are decocted with water secondary, boiling temps is 120 ℃, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.35 Chinese crude drug thick paste that 60 ℃ of lower filtrate is concentrated into relative density, stand-by;
3) ripe Folium Eriobotryae is removed skin and pit, the Folium Eriobotryae meat that obtains with crusher in crushing behind the wash clean, for subsequent use.
4) with step 2) the Chinese crude drug thick paste that obtains adds 300 gram steps 3) the Folium Eriobotryae meat that obtains, be to boil under 100 ℃ 2 hours at boiling temps, filtering filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 10 that obtains restrains mix and blends makes evenly, and it is 1.35 that 60 ℃ of lower filtrates are concentrated into relative density, let cool, after being cooled to 55 ℃, add water to ormal weight, stir evenly, and get final product, bottle, sterilize, seal, be packaged into product.
Embodiment 2
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae 50 grams and be ground into coarse powder, ooze method according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1～1.2 thick paste, stand-by.
2) preparation method of Chinese medicine extract:
Radix Glehniae 9 grams, Flos Farfarae 7 grams, Rhizoma Polygonati Odorati 7 grams, Herba Violae 8 grams, Ilex rotunda Thunb. 6 grams, Bulbus Lilii 7 grams, Pericarpium Citri Reticulatae 7 grams, the Rhizoma Pinelliae 7 grams, Cortex Magnoliae Officinalis 6 grams, Fructus Perillae 8 grams, Radix Glycyrrhizae 5 grams, Radix Codonopsis 6 grams are decocted with water secondary, boiling temps is 100 ℃, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.35 Chinese crude drug thick paste that 60 ℃ of lower filtrate is concentrated into relative density, stand-by;
3) ripe Folium Eriobotryae is removed skin and pit, the Folium Eriobotryae meat that obtains with crusher in crushing behind the wash clean, for subsequent use.
4) with step 2) the Chinese crude drug thick paste that obtains adds 300 gram steps 3) the Folium Eriobotryae meat and white sugar 50 grams that obtain, being to boil under 100 ℃ 2 hours at boiling temps, filtering filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 10 that obtains restrains mix and blends makes evenly, it is 1.35 that 60 ℃ of lower filtrates are concentrated into relative density, let cool, be cooled to 55 ℃ after, add 0.10% the amount that Mentholum accounts for total amount, add water to ormal weight, stir evenly, and get final product, bottle, sterilize, seal, be packaged into product.
Claims (3)
1. loquat extract extracted from loquat pulp is characterized in that it is to be made by the raw material of following weight proportioning:
Fractus Eriobotryae 200-400 part, Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Bulbus Fritillariae Cirrhosae fluidextract 8-12 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part; Its preparation method comprises the steps: 1) described Bulbus Fritillariae Cirrhosae fluidextract makes by following method:
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, according to oozing method under the fluid extract among appendix IO of Chinese Pharmacopoeia version in 2000 and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, and device is preserved in addition, continue percolation, the wait soluble component is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, adds the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1～1.2 thick paste;
2) Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part are decocted with water secondary, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.25～1.40 Chinese crude drug thick paste that 60 ℃ of lower filtrate is concentrated into relative density, stand-by;
3) ripe Fractus Eriobotryae is removed skin and pit, obtain Folium Eriobotryae meat with crusher in crushing behind the wash clean, for subsequent use;
4) with step 2) the Chinese crude drug thick paste that obtains adds through step 3) the Folium Eriobotryae meat that makes, boiled 2 hours, filter, filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 8-12 part mix and blend of obtaining makes evenly, it is 1.25～1.40 that 60 ℃ of lower filtrates are concentrated into relative density, lets cool, and adds water to ormal weight, stir evenly, bottle, sterilize, seal, be packaged into product.
2. the preparation method of a kind of loquat extract extracted from loquat pulp claimed in claim 1 comprises the steps:
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, according to oozing method under the fluid extract among appendix IO of Chinese Pharmacopoeia version in 2000 and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the wait soluble component is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1～1.2 thick paste, stand-by;
2) preparation method of Chinese medicine extract:
Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part are decocted with water secondary, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.25～1.40 Chinese crude drug thick paste that 60 ℃ of lower filtrate is concentrated into relative density, stand-by;
3) ripe Folium Eriobotryae is removed skin and pit, obtain Folium Eriobotryae meat with crusher in crushing behind the wash clean, for subsequent use;
4) with step 2) the Chinese crude drug thick paste that obtains adds through step 3) the Folium Eriobotryae meat that makes, boiled 2 hours, filter, filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 8-12 part mix and blend of obtaining makes evenly, it is 1.25～1.40 that 60 ℃ of lower filtrates are concentrated into relative density, lets cool, and adds water to ormal weight, stir evenly, bottle, sterilize, seal, be packaged into product.
3. the preparation method of a loquat extract extracted from loquat pulp comprises the steps:
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, according to oozing method under the fluid extract among appendix IO of Chinese Pharmacopoeia version in 2000 and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the wait soluble component is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1～1.2 thick paste, stand-by;
2) preparation method of Chinese medicine extract:
Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part are decocted with water secondary, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.25～1.40 Chinese crude drug thick paste that 60 ℃ of lower filtrate is concentrated into relative density, stand-by;
3) the ripe Fractus Eriobotryae of 200-400 part is removed skin and pit, the Folium Eriobotryae meat that obtains with crusher in crushing behind the wash clean, for subsequent use;
4) with step 2) the Chinese crude drug thick paste that obtains adds step 3) the Folium Eriobotryae meat and the white sugar that obtain, boiled 2 hours, filtering filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 8-12 part mix and blend of acquisition makes evenly, and it is 1.25～1.40 that 60 ℃ of lower filtrates are concentrated into relative density, let cool, after being cooled to 55 ℃, add Mentholum, add water to ormal weight, stir evenly, bottle, sterilize, seal, be packaged into product.
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|---|---|---|---|---|
| CN1857593A (en) * | 2005-08-23 | 2006-11-08 | 贵州百灵企业集团制药有限公司 | Cough-treating keliting preparation and its preparing process |
| CN101637561A (en) * | 2008-07-29 | 2010-02-03 | 重庆希尔安药业有限公司 | Fritillary-loquat medicinal composition and preparation method thereof |
| CN101732555A (en) * | 2010-02-03 | 2010-06-16 | 江西南昌济生制药厂 | Medicament for treating cold cough and chronic bronchitis |
-
2010
- 2010-11-10 CN CN 201010537227 patent/CN101991773B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857593A (en) * | 2005-08-23 | 2006-11-08 | 贵州百灵企业集团制药有限公司 | Cough-treating keliting preparation and its preparing process |
| CN101637561A (en) * | 2008-07-29 | 2010-02-03 | 重庆希尔安药业有限公司 | Fritillary-loquat medicinal composition and preparation method thereof |
| CN101732555A (en) * | 2010-02-03 | 2010-06-16 | 江西南昌济生制药厂 | Medicament for treating cold cough and chronic bronchitis |
Non-Patent Citations (2)
| Title |
|---|
| 国家药典委员会标准一室.蜜炼川贝枇杷膏质量标准.《中国药品标准》.2001,第2卷(第4期),22-23页. |
| 蜜炼川贝枇杷膏质量标准;国家药典委员会标准一室;《中国药品标准》;20011231;第2卷(第4期);22-23页 * |
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| Publication number | Publication date |
|---|---|
| CN101991773A (en) | 2011-03-30 |
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