CN101991773A - Loquat extract extracted from loquat pulp and preparation method thereof - Google Patents

Loquat extract extracted from loquat pulp and preparation method thereof Download PDF

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CN101991773A
CN101991773A CN2010105372271A CN201010537227A CN101991773A CN 101991773 A CN101991773 A CN 101991773A CN 2010105372271 A CN2010105372271 A CN 2010105372271A CN 201010537227 A CN201010537227 A CN 201010537227A CN 101991773 A CN101991773 A CN 101991773A
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CN101991773B (en
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胡枝清
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Abstract

The invention discloses a loquat extract extracted from loquat pulp and a preparation method thereof. The loquat extract is prepared from the following ingredients in percent by weight: 200 to 400 parts of loquat, 6 to 10 parts of radix glehniae, 5 to 9 parts of coltsfoot, 8 to 12 parts of fritillaria cirrhosa fluid extract, 5 to 9 parts of polygonatum, 6 to 10 parts of Chinese violet, 4 to 8 parts of ilex rotunda, 5 to 9 parts of lily, 5 to 9 parts of dried orange peel, 5 to 9 parts of tuber pinellia, 4 to 8 parts of cortex magnoliae officinalis, 6 to 10 parts of perilla-seed, 3 to 7 parts of liquorice and 4 to 8 parts of radix codonopsitis. The preparation method comprises the following steps of: preparing the fritillaria cirrhosa fluid extract; preparing Chinese medicine extracts; crushing the obtained loquat pulp through a crushing machine; adding the loquat pulp and the white granulated sugar into the obtained Chinese medicine thick paste; boiling the materials for 2 hours; filtering the materials; mixing and uniformly stirring filter liquid with 8 to 12 parts of the obtained fritillaria cirrhosa fluid extract; concentrating the filter liquid to a relative density between 1.25 and 1.40 at 60 DEG C; standing and cooling the materials to 55 DEG C; adding menthol; adding water to a specified quantity; and uniformly stirring the materials to obtain the loquat extract.

Description

A kind of Folium Eriobotryae meat refines into loquat leaf extract and preparation method thereof
Technical field:
The invention belongs to health product and field of medicaments, especially belong to a kind of Folium Eriobotryae meat that adopts Chinese medicine to be mixed with and refine into loquat leaf extract and preparation method thereof.
Background technology:
Folium Eriobotryae is different with most of fruit tree, in autumn or open early winter luxuriant, fruit spring to maturation early summer, all more Zao than other fruit, therefore claimed to be solely to be equipped with in the fruit tree seasonal pathogens,exopathogens person, sophisticated Folium Eriobotryae fruit is that bunchy is hung in the tree, sophisticated Folium Eriobotryae taste is pretty good, nutrition is rich, various fructose, glucose, potassium, phosphorus, ferrum, calcium and vitamin A, B, C etc. are arranged, leaf and fruit medicine have effects such as heat clearing away, lung moistening, relieving cough and resolving phlegm, and the traditional Chinese medical science is thought the function that loquat has lung moistening, cough-relieving, quenches the thirst.
Having the existing many reports of medicine of nourishing YIN and moistening the lung and eliminating phlegm and stopping cough at present, is 2008100724915 as application number, and its prescription is: Flos Eriobotryae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis and Semen Armeniacae Amarum, generally all use Folium Eriobotryae, Flos Eriobotryae etc. in the prescription, and seldom see the employing Fractus Eriobotryae; And the Chinese crude drug composition is also less in the described prescription, and these have all restricted as treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to the stagnation of fire in the interior, laryngopharynx swelling and pain, breast distending pain, the effect of symptoms such as cold cough and chronic bronchitis.
Summary of the invention:
The object of the present invention is to provide a kind of cough the eliminated symptom that several kinds of Chinese medicinal materials and Fractus Eriobotryae be mixed with and Folium Eriobotryae meat of healing of adopting to refine into loquat leaf extract and preparation method thereof.
The object of the present invention is achieved like this, and described a kind of Folium Eriobotryae meat refines into loquat leaf extract and preparation method thereof, and it is to be made by the following weight proportion raw material:
Fractus Eriobotryae 200-400 part, Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Bulbus Fritillariae Cirrhosae fluidextract 8-12 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part.
Optimization formula is: 300 parts of Fractus Eriobotryaes, 8 parts of Radix Glehniaes, 7 parts of Flos Farfaraes, 10 parts of Bulbus Fritillariae Cirrhosae fluidextracts, 7 parts of Rhizoma Polygonati Odorati, 8 parts of Herba Violaes, 6 parts of Ilex rotunda Thunb.s, 7 parts of Bulbus Liliies, 7 parts of Pericarpium Citri Reticulataes, 7 parts of the Rhizoma Pinelliaes, 6 parts of Cortex Magnoliae Officinalis, 8 parts of Fructus Perillaes, 5 parts in Radix Glycyrrhizae, 6 parts of Radix Codonopsis.
The preparation method of Bulbus Fritillariae Cirrhosae fluidextract is as follows: following % is weight percentage.
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, ooze method, make solvent with 70% ethanol according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid of just filtering, and device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, adds the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1~1.2 thick paste.
The present inventor studies intensively and clinical verification continuously through two more than ten years, and this loquat leaf extract has the treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to the stagnation of fire in the interior, laryngopharynx swelling and pain, breast distending pain, symptoms such as cold cough and chronic bronchitis.In the prescription 1) Fractus Eriobotryae: [performance] sweet in the mouth, little acid, cool in nature.The energy nourishing the lung to arrest cough, promoting the production of body fluid to quench thirst, regulating the stomach and sending down the abnormal ascending QI.[reference] sarcocarp contains sugar, protein, fat, pectin, carotene, vitamin B1, C, compositions such as tartaric acid, malic acid, citric acid.[purposes] is used for lung-dryness syndrome due to deficiency of YIN, cough, or spitting of blood; Deficiency of stomach-Yin, dry throat and mouth, or QI failing to descend, retch loss of appetite.[usage] eaten raw, endures cream, or fries in shallow oil soup.2) Radix Glehniae, [function cures mainly] nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.It is thirsty to be used for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.3) Flos Farfarae, function with cure mainly: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Be used for new chronic cough and cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.4) Bulbus Fritillariae Cirrhosae, [function cures mainly] clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Control cough due to consumptive disease, the spitting of blood of spitting, ambition Yu Jie, consumptive lung disease, lung abscess, sore throat, acute mastitis; 5) Rhizoma Polygonati Odorati, nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain; 6) Herba Violae, function cures mainly: can be used as medicine its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood detumescence.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.7) Ilex rotunda Thunb., effect cures mainly: heat-clearing and toxic substances removing; Dampness removing; Pain relieving.Cold, fever; Laryngopharynx swelling and pain; Stomachache; Administration's diarrhea due to damp pathogen rushes down; Jaundice; Dysentery; Traumatic injury; Rheumatic arthralgia; Eczema; Furuncle.8) Bulbus Lilii cures mainly: be used for the xeropulmonary cough, chronic cough of deficiency lung, sputum mixed with blood; Deficiency of YIN chronic cough; Sputum mixed with blood; The calentura later stage; Waste heat is unclear, or fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, the absentminded of feelings will due to unsuccessful; Carbuncle; Eczema; 9) Pericarpium Citri Reticulatae, the merit of appetizing in tool regulating QI and lowering the adverseness, the accent, drying dampness to eliminate phlegm.Cure mainly dirty contrary, the difficulty in urination and defecation of full vexed, the abdominal distention of the wet resistance of stagnation of QI in spleen and stomach, chest and diaphragm, anorexia, vomiting, lung qi retardance, cough with copious phlegm, also control acute mastitis from the beginning of.Through research for many years, existing known Pericarpium Citri Reticulatae has many pharmacological actions.10) Rhizoma Pinelliae, function cures mainly, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Be used for that abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant are dizzy, syncope due to accumulation of phlegm headache, vomiting regurgitation, vexed, the globus hystericus disease of breast gastral cavity painful abdominal mass; Give birth to external treatment carbuncle sucutaneous nodule.11) Cortex Magnoliae Officinalis, [effect] alleviating distention in middle-JIAO is regulated the flow of vital energy, the removing dampness dissipating depression of QI.Deficiency and coldness of spleen and stomach, abdominal part dull pain.12) Fructus Perillae, function cures mainly: the sending down the abnormal ascending QI expectorant, relieving asthma intestine moistening.Be used for expectorant and stop up QI rising in reverse order, cough and asthma, dryness of the intestine constipation.13) Radix Glycyrrhizae, [function cures mainly]: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.14) Radix Codonopsis, Radix Codonopsis has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc." Bencao Congxin " record: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than the middle feeble QI, mend in order to transfer, very smooth and proper.”。More than 14 kinds of medicines share, clearing heat and moistening lung are arranged, preventing phlegm from forming and stopping coughing, removing stasis to stop bleeding, the merit of nourishing qi to stop, altogether assistant helps all medicines of the monarch and his subjects to control all diseases of cough, flu.
Can do paste making agent, oral solid formulation or the oral liquid etc. of Chinese medicine preparation of the present invention all can.
Folium Eriobotryae meat of the present invention refines into the preparation method of loquat leaf extract: Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to (appendix IO of Chinese Pharmacopoeia version in 2000) percolation under fluid extract and the extractum item, makes solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, gets the liquid of filtering and is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1~1.2 Bulbus Fritillariae Cirrhosae thick paste, standby; The Radix Glehniae, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygonati Odorati, Herba Violae, Ilex rotunda Thunb., Bulbus Lilii, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Perillae, Radix Glycyrrhizae, the Radix Codonopsis that take by weighing above-mentioned formula ratio in proportion decoct with water secondary, boiling temps can reach 120 ℃, 2-3 hour for the first time, 1.5-2.5 hour for the second time, collecting decoction, filter filtrate, filtrate is concentrated into relative density is preferably 1.25~1.40 Chinese crude drug thick paste (being 60 ℃ with temperature is as the criterion).The Chinese crude drug thick paste adds Folium Eriobotryae meat, also can add an amount of white sugar, boils 1-3 hour, boiling temps can reach 110 ℃, filters, and filter screen can be 20 purpose filter screens, filtrate and Bulbus Fritillariae Cirrhosae thick paste mix homogeneously, continuing to be concentrated into relative density under 60 ℃ is 1.25~1.40, puts cold, after being cooled to 55 ℃, can add the adjuvant Mentholum, add water to ormal weight, stir evenly, that is, bottle, sterilize, seal, be packaged into product.Mentholum can account for the 0.05-0.12% of gross weight.
Above-mentioned Folium Eriobotryae meat is that ripe Folium Eriobotryae is removed skin and pit, uses behind the wash clean to be obtained by broken crusher machine.
Loquat leaf extract of the present invention belongs to the oral type unguentum, adult every day 2~3 times, each soupspoon (about 15mL).
According to traditional Chinese medical science traditional theory, diaphoresis such as the Bulbus Fritillariae Cirrhosae diuretic of relievining asthma, monarch drug in the side of being, relieving cough and reducing sputum; Expectorant cough suppressant and anti-asthmatics such as loquat are ministerial drug in the side; The Radix Codonopsis invigorating the spleen and replenishing QI is adjuvant drug in the side; Pale reddish brown ground T etc. has heat-clearing and toxic substances removing, and the removing heat from blood detumescence reaches the antiinflammatory effect; Radix Glycyrrhizaes etc. are reduced phlegm, and Synergistic is an accessory drugs.The present invention not only relieving cough and reducing sputum but also antiinflammatory reach synergistic action effect.The present invention selects unguentum for use.But also tablet, granule, capsule, soft capsule, drop pill, pill etc.
Because loquat leaf extract of the present invention is primary raw material with the loquat fruit, with Radix Glehniae, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygonati Odorati, Herba Violae, Ilex rotunda Thunb., Bulbus Lilii, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Perillae, Radix Glycyrrhizae, Radix Codonopsis is that Chinese crude drug and sucrose are adjuvant, therefore has the function of clearing away lung-heat to relieve cough and stopping nausea and vomiting by lowering the adverse flow of QI, for lung-heat type cough, the few dry pharynx of expectorant, stay up late and tobacco and wine are excessive etc. has a good effect.The function of lung moistening, cough-relieving are arranged, quenching the thirst.In addition, production technology of the present invention is simple, does not have environmental pollution.
Loquat leaf extract of the present invention is the treatment wind-heat invading the lung, cough expectorant Huang or ungratifying ejection of phlegm due to the stagnation of fire in the interior, laryngopharynx swelling and pain, the breast distending pain, the oral syrup class pure Chinese medicinal preparation of symptom such as cold cough and chronic bronchitis is through clinical verification for many years, steady quality, determined curative effect is the common drug preparation that clinical and family is used for the treatment of above disease.Other similar oral formulations also has the watered pill, tablet etc., and its characteristics are similar, act on basic identical, no significant difference.
The specific embodiment:
The present invention is described in detail below in conjunction with embodiment:
Embodiment 1
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae 50 grams and be ground into coarse powder, ooze method, make solvent with 70% ethanol according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1~1.2 thick paste, stand-by.
2) preparation method of Chinese medicine extract:
Radix Glehniae 8 grams, Flos Farfarae 7 grams, Rhizoma Polygonati Odorati 7 grams, Herba Violae 8 grams, Ilex rotunda Thunb. 6 grams, Bulbus Lilii 7 grams, Pericarpium Citri Reticulatae 7 grams, the Rhizoma Pinelliae 7 grams, Cortex Magnoliae Officinalis 6 grams, Fructus Perillae 8 grams, Radix Glycyrrhizae 5 grams, Radix Codonopsis 6 grams are decocted with water secondary, boiling temps is 120 ℃, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.35 Chinese crude drug thick paste that 60 ℃ of following filtrate is concentrated into relative density, stand-by;
3) ripe Folium Eriobotryae is removed skin and pit, the Folium Eriobotryae meat that obtains with crusher in crushing behind the wash clean, standby.
4) with step 2) the Chinese crude drug thick paste that obtains adds the Folium Eriobotryae meat that 300 gram step 3) obtain, at boiling temps is to boil under 100 ℃ 2 hours, filtering filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 10 grams that obtain mix stirring makes evenly, and it is 1.35 that 60 ℃ of following filtrates are concentrated into relative density, put cold, after being cooled to 55 ℃, add water to ormal weight, stir evenly, that is, bottle, sterilize, seal, be packaged into product.
Embodiment 2
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae 50 grams and be ground into coarse powder, ooze method, make solvent with 70% ethanol according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1~1.2 thick paste, stand-by.
2) preparation method of Chinese medicine extract:
Radix Glehniae 9 grams, Flos Farfarae 7 grams, Rhizoma Polygonati Odorati 7 grams, Herba Violae 8 grams, Ilex rotunda Thunb. 6 grams, Bulbus Lilii 7 grams, Pericarpium Citri Reticulatae 7 grams, the Rhizoma Pinelliae 7 grams, Cortex Magnoliae Officinalis 6 grams, Fructus Perillae 8 grams, Radix Glycyrrhizae 5 grams, Radix Codonopsis 6 grams are decocted with water secondary, boiling temps is 100 ℃, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.35 Chinese crude drug thick paste that 60 ℃ of following filtrate is concentrated into relative density, stand-by;
3) ripe Folium Eriobotryae is removed skin and pit, the Folium Eriobotryae meat that obtains with crusher in crushing behind the wash clean, standby.
4) with step 2) the Chinese crude drug thick paste that obtains adds Folium Eriobotryae meat and white sugars 50 grams that 300 gram step 3) obtain, at boiling temps is to boil under 100 ℃ 2 hours, filters filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 10 grams that obtain mix stirring makes even, it is 1.35 that 60 ℃ of following filtrates are concentrated into relative density, put cold, be cooled to 55 ℃ after, add 0.10% the amount that Mentholum accounts for total amount, add water to ormal weight, stir evenly, that is, bottle, sterilize, seal, be packaged into product.

Claims (3)

1. a Folium Eriobotryae meat refines into loquat leaf extract, it is characterized in that it is to be made by the following weight proportion raw material:
Fractus Eriobotryae 200-400 part, Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Bulbus Fritillariae Cirrhosae fluidextract 8-12 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part; Described Bulbus Fritillariae Cirrhosae fluidextract is made by following method:
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, ooze method, make solvent with 70% ethanol according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid of just filtering, and device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, adds the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1~1.2 thick paste.
2. the described a kind of Folium Eriobotryae meat of claim 1 preparation method of refining into loquat leaf extract comprises the steps:
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, ooze method, make solvent with 70% ethanol according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1~1.2 thick paste, stand-by;
2) preparation method of Chinese medicine extract:
Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part are decocted with water secondary, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.25~1.40 Chinese crude drug thick paste that 60 ℃ of following filtrate is concentrated into relative density, stand-by;
3) ripe Folium Eriobotryae is removed skin and pit, the Folium Eriobotryae meat that obtains with crusher in crushing behind the wash clean, standby;
4) with step 2) the Chinese crude drug thick paste that obtains adds the Folium Eriobotryae meat that 200-400 part step 3) obtains, boiled 2 hours, filter, filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 8-12 part of obtaining mixes to stir makes evenly, and it is 1.25~1.40 that 60 ℃ of following filtrates are concentrated into relative density, puts cold, add water to ormal weight, stir evenly, that is, bottle, sterilize, seal, be packaged into product.
3. the described a kind of Folium Eriobotryae meat of claim 1 preparation method of refining into loquat leaf extract comprises the steps:
1) preparation method of Bulbus Fritillariae Cirrhosae fluidextract:
Get Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, ooze method, make solvent with 70% ethanol according to (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid of just filtering, device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, and the continuous liquid of filtering is concentrated in right amount, add the liquid of just filtering, mix, continue to be concentrated into relative density under 60 ℃ and be 1.1~1.2 thick paste, stand-by;
2) preparation method of Chinese medicine extract:
Radix Glehniae 6-10 part, Flos Farfarae 5-9 part, Rhizoma Polygonati Odorati 5-9 part, Herba Violae 6-10 part, Ilex rotunda Thunb. 4-8 part, Bulbus Lilii 5-9 part, Pericarpium Citri Reticulatae 5-9 part, Rhizoma Pinelliae 5-9 part, Cortex Magnoliae Officinalis 4-8 part, Fructus Perillae 6-10 part, Radix Glycyrrhizae 3-7 part, Radix Codonopsis 4-8 part are decocted with water secondary, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.25~1.40 Chinese crude drug thick paste that 60 ℃ of following filtrate is concentrated into relative density, stand-by;
3) ripe Folium Eriobotryae is removed skin and pit, the Folium Eriobotryae meat that obtains with crusher in crushing behind the wash clean, standby;
4) with step 2) the Chinese crude drug thick paste that obtains adds Folium Eriobotryae meat and the white sugar that step 3) obtains, boiled 2 hours, and filtered, filtrate and above-mentioned steps 1) Bulbus Fritillariae Cirrhosae fluidextract 8-12 part of obtaining is mixed stirring makes even, it is 1.25~1.40 that 60 ℃ of following filtrates are concentrated into relative density, put cold, be cooled to 55 ℃ after, add Mentholum, add water to ormal weight, stir evenly, that is, bottle, sterilize, seal, be packaged into product.
CN 201010537227 2010-11-10 2010-11-10 Loquat extract extracted from loquat pulp and preparation method thereof Expired - Fee Related CN101991773B (en)

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