KR102282839B1 - Composition for relieving or improving hangover - Google Patents

Abstract

The present invention relates to a composition for relieving, improving, preventing or treating a hangover, comprising, as an active ingredient, any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract, comprising the extract of the present invention as an active ingredient. It was confirmed that the composition promotes the production of alcohol dehydrogenase (ADH) to promote alcohol decomposition, and in particular, the combination of taekran, ginkgo biloba and haedongpi extract has a synergistic effect on the alcohol decomposition promoting effect. Accordingly, the composition of the present invention can be applied to a food composition, a health functional food composition, a pharmaceutical composition, a quasi-drug composition, and the like for relieving or improving a hangover.

Description

Composition for relieving or improving hangover

The present invention relates to a composition comprising, as an active ingredient, any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract, specifically, a hangover relieving or alleviating food composition comprising the extract, and a hangover comprising the extract It relates to a health functional food composition for relieving or improving, a pharmaceutical composition, and a quasi-drug composition.

A hangover is a general term for physical and mental discomfort that occurs after drinking. The objective symptoms include headache, nausea, vomiting, drowsiness, decreased exercise capacity, hematologic changes, and hormonal changes. Although the exact cause of hangover is not yet known, it is reported that it is caused by metabolites generated during alcohol metabolism.

Ethyl alcohol introduced into the body is absorbed in the stomach or small intestine, enters the blood vessels, and is transferred to the liver. Hepatocytes contain alcohol dehydrogenase (ADH) that oxidizes alcohol to acetaldehyde, which is converted to acetic acid by acetaldehyde dehydrogenase (ALDH) in hepatocytes and is excreted in urine or sweat. or excreted as carbon dioxide in the lungs.

Existing hangover improving materials are mainly related to the mechanism of increasing the activity of alcohol degrading enzyme (ADH) or aldehyde degrading enzyme (ALDH) itself, and are independent of the absolute amount of enzyme produced. (References: Patents 10-188279, 10-1845704, 10-1725261)

In addition, since the objective verification of the efficacy of the final finished product for most products is insufficient, the reality is that the reliability of consumers who actually need a hangover relieving drink is not generally high. Therefore, there is an urgent need to develop an effective product for reliable hangover relieving through verification of hangover relieving efficacy.

Accordingly, the present invention is a result of diligent efforts to find a natural product that is effective in relieving or improving a hangover. As a result, the plant extract of the present invention increases the expression of alcohol dehydrogenase (ADH), an alcohol dehydrogenase, to promote alcohol decomposition, thereby relieving or improving hangover. It was confirmed that the effect was completed, and the present invention was completed.

One object of the present invention is to provide a food composition for relieving or improving a hangover, comprising as an active ingredient any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract.

Another object of the present invention is to provide a health functional food composition for relieving or improving a hangover, comprising as an active ingredient any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract.

Another object of the present invention is to provide a pharmaceutical composition for relieving or improving a hangover comprising any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract as an active ingredient.

Another object of the present invention is to provide a quasi-drug composition for relieving or improving a hangover comprising any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract as an active ingredient.

This will be described in detail as follows. Meanwhile, each description and embodiment disclosed in the present invention may be applied to each other description and embodiment. That is, all combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be considered that the scope of the present invention is limited by the specific descriptions described below.

In the present invention, the hangover relieving or improving effect could be confirmed by the composition comprising any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract as an active ingredient, and the present invention is based on this.

Hereinafter, the configuration of the present invention will be described in detail.

In order to achieve the above object, one aspect of the present invention provides a food composition for relieving or improving a hangover comprising as an active ingredient any one or more extracts selected from taekran extract, ginkgo leaf extract, and haedongpi extract.

The term 'Taekran (澤蘭, Lycopus lucidus Turcz.)' used in the present invention is also called Shipsari, Horan, and Sotaekran, and is a perennial herbaceous plant that is a perennial herbaceous plant in the Lamiaceae family that has dried the leaves of will be. Whole plants are essential oils, glucosides, tannins, wood ginseng, flavonoid glycosides, phenols, amino acids, organic acids, saponins, glucose, galactose, lycopose, sucrose, raffinose, stachyose, It is composed of fructose, etc., and the main components of fruit are glucose, galactose, lycopose, sucrose, raffinose, and stachyose (Changmin Kim et al., Jeongdam Books Publishing, The Dictionary of Traditional Chinese Medicine) , Vol. 6, p2598, 1997). It promotes blood circulation, eliminates eohyeol, smoothes menstruation, and makes urine flow well. In pharmacological experiments, it has been found to have a strong heart action, analgesic action, and hemostasis action. (Reference: Dictionary of Oriental Medicine)

The term 'Ginkgo leaf' used in the present invention is described in the Chinese Pharmacopoeia that the Ginkgo leaf is the leaf of Ginkgo biloba L., and has been used as a treatment for asthma and bronchitis for about 5,000 years, and its medicinal effect is still present. being evaluated. Recently, it has been widely used as a treatment for senile peripheral circulatory disorders, cerebrovascular disorders, and asthma in Asia and Europe. Ginkgo biloba extract was patented in Europe in 1972 and is widely used as a therapeutic agent for the cardiovascular system. It is known that the pharmacological action of ginkgo leaves is mainly due to flavonoid compounds and terpene compounds among the components of ginkgo leaves.

In particular, in the present invention, an extract of ginkgo leaves was used, and it was confirmed that the expression of alcohol degrading enzyme was increased compared to when the extracts of the root and stem fruit parts of ginkgo biloba were treated (see Table 1).

The term 'Haedongpi' used in the present invention is the bark of yum tree (Kalopanax pictus Nakai, Kalopanax septemlobus (Thunb. ex Murray) Koidz.), which removes the wind chimes, allows the meridians to pass well, stops pain, and pharmacologically In experiments, it was found that the central nervous system excitability (small amount), sedative action (large amount), gastric juice secretion, expectoration, anti-inflammatory action, antibacterial action, etc. (Reference: Dictionary of Oriental Medicine)

The above extracts of taekran, ginkgo biloba, or thawed blood have not been disclosed for use in relieving or improving hangovers, and the present inventors for the first time have found that there is a hangover relieving or improving effect due to the effect of promoting the production of alcohol-degrading enzymes and the promoting effect of alcohol decomposition. has been identified

The food composition for relieving or improving hangover may further include any one or more extracts selected from milk thistle extract, pilbal extract, hocho extract, arborvitae extract, creation extract and laurel extract.

The term 'milk thistle (Silybum marianum L.)' used in the present invention is also called Cardus marianus or white patterned milk thistle, and it is known that it can help liver health. Silymarin, the main component of milk thistle, is known to have protective and detoxifying effects on hepatocytes due to its antioxidant action, but there is no known use for relieving or improving hangovers.

The term 'Piper longum L.' used in the present invention is a plant of the pepper family and is used for chest and stomach pain, vomiting, diarrhea, dysentery, um acid, headache, sinusitis, toothache, and the like. (Reference: Dictionary of Oriental Medicine)

The term 'Hocho' used in the present invention is a dried fruit of the pepper family, Piper nigrum L. It is known that it warms the middle and lowers the qi, clears and detoxifies the phlegm, and the spicy and aromatic components of hocho promote the secretion of digestive juices and speed up intestinal peristalsis. (Reference: Dictionary of Oriental Medicine)

As used herein, the term 'arborvitae' refers to dried branches or leaves of Thuja orientalis L. / Biota orientalis L. It has been found that the leaf has a hemostatic effect by removing heat exhaustion from blood meal and stopping bleeding, and in pharmacological experiments, the leaf narrows blood vessels and promotes clotting. (Reference: Dictionary of Oriental Medicine)

The term 'creativity' used in the present invention is the rhizome of Atractylodes lancea De Candlle or Atractylodes chinensis Koidzumi, which is known to strengthen the stomach and prevent obesity in oriental medicine. In addition, it is known that when used in colds, it causes sweating, has an inhibitory effect on pathogens, and increases tolerance.

The term 'laurel (Laurus nobilis L.)' used in the present invention is an evergreen arboreous tree of the camphor family, and it is known that it aids in diuresis, promotes digestion, and has anticancer action. The leaves are used as a spice to stimulate the taste buds with a sweet and fragrant scent. It is also known to be effective in promoting digestion, stabilizing the mind and body, preventing hair loss, and preventing aging.

As used in the present invention, the term "extract" refers to a liquid component obtained by immersing a target substance in various solvents and then extracting it for a certain time at room temperature, low temperature or a heated state, and removing the solvent from the liquid component. It means a result such as the obtained solid content. In addition, in addition to the result, it can be comprehensively interpreted as including all of the diluent of the result, the concentrate thereof, the prepared product thereof, the purified product, and the like.

In the present invention, the extract may mean any one or more selected from taekran extract, ginkgo leaf extract, haedongpi extract, milk thistle extract, pilbal extract, hocho extract, arborvitae extract, creation extract, and laurel extract.

The taekran, ginkgo leaf, haedongpi, milk thistle, pilbal, hocho, arborvitae, chrysanthemum or laurel of the present invention may be purchased commercially, or collected or cultivated in nature may be used.

The taekran, ginkgo leaf, haedongpi, milk thistle, pilbal, hocho, arborvitae, chrysanthemum or laurel extract may be extracted from various organs of natural, hybrid, and variegated plants, for example, roots, above-ground parts, stems, leaves, flowers, It can be extracted from fruit body, fruit skin, as well as plant tissue culture.

The extract can be obtained by extraction with water or various organic solvents. At this time, the organic solvent used is not particularly limited thereto, as long as an extract having a hangover relieving or improving effect can be obtained, specifically water, a polar solvent or a non-polar solvent, and more specifically water, carbon number 1 to 6 lower alcohols (methanol, ethanol, propanol or butanol, etc.), may be a mixed solvent thereof, and most specifically may be methanol or a mixed solvent thereof. In addition, the method for obtaining the extract is also not particularly limited thereto, as long as an extract having the effect of relieving a hangover or improving can be obtained, but specifically, the above taekran, ginkgo biloba, haedongpi, milk thistle, pilbal, hocho, Cold extraction method of immersing the roots, stems, leaves, fruits, flowers, dried products, processed products, etc. of arborvitae, chrysanthemum or laurel in the above solvent and extracting them at room temperature, heating extraction method by heating to 40 to 100 ° C, ultrasonic extraction Methods such as an ultrasonic extraction method for extraction by addition and a reflux extraction method using a reflux condenser can be used.

In one embodiment of the present invention, the taekran, ginkgo leaf, haedongpi, milk thistle, pilbal, hocho, arborvitae, chrysanthemum or laurel extract is concentrated after extraction, filtration, fractionation, drying, grinding, etc. It can be applied to the extract of a plant. It may include a concentrate, a filtrate, a fraction, a dried product, a pulverized product, and the like, prepared by an additional process of In this case, the 'concentrate' may refer to a substance in which the concentration of a main solid component is increased by removing a solvent, etc. from a chemical substance, and the 'filtrate' is a material in which a liquid and a solid are mixed using the difference in particle size. The substance obtained by the separation method, the 'fraction' is a product obtained by a fractionation method for separating a specific component or a specific group from a mixture containing various components, and the 'dry product' is a material containing a small amount of water The result obtained by the method of removing the 'pulverized material' may mean a result obtained by a method of making small particles by crushing or cutting the solid particles by applying force. In this case, the concentrate, the filtrate, the fraction, the dried product, the pulverized product, etc. may be obtained by a conventional method for obtaining the corresponding product, and is not particularly limited.

The composition comprising the extract of taekran, ginkgo biloba or haedongpi extract of the present invention can be used to relieve or improve a hangover.

As used herein, the term 'hangover' refers to a general term for physical and mental discomfort after drinking. The objective symptoms include headache, nausea, vomiting, drowsiness, decreased exercise capacity, hematologic changes, and hormonal changes. Although the cause of hangover is not yet known precisely, it is generally known that it is highly related to acetaldehyde, a metabolite generated during alcohol metabolism. That is, it is generally known that hangover occurs when the concentration of acetaldehyde remaining in the body is high.

The term 'relief' as used in the present invention means any act of reducing or eliminating symptoms of a hangover by ingesting a food composition for relieving or improving a hangover comprising the composition according to the present invention.

The term 'improvement' as used in the present invention refers to all actions that reduce at least the degree of a symptom, for example, a parameter related to a condition in which symptoms are improved by ingestion of a food composition for relieving or improving a hangover comprising the composition according to the present invention. it means.

In one embodiment of the present invention, it was confirmed that the extract of taekran, ginkgo leaf or haedongpi promotes the production of alcohol dehydrogenase (ADH), which is an alcohol degrading enzyme, in hepatocytes (Table 1). In addition, it was confirmed that the ability to promote alcohol dehydrogenase production in the extract of ginkgo leaves was superior to that of the stem, root, and fruit parts of ginkgo biloba (Table 1).

In addition, it was confirmed that when the taekran, ginkgo leaf or haedongpi extract was ingested, the aerobic alcohol concentration was reduced (Table 3).

Through the above results, it was confirmed that the taekran, ginkgo leaf or haedongpi extract has the effect of relieving or improving the hangover as the alcohol-decomposing effect is promoted by increasing the expression of the alcohol-decomposing enzyme. In addition, it was confirmed that the alcohol decomposition effect was further increased due to the synergistic effect in the case of the combination of taekran, ginkgo leaf and haedongpi extract (Tables 2 and 3).

In addition, as well as the extracts of taekran, ginkgo biloba, or haedongpi, milk thistle, pilbal, hocho, arborvitae, chrysanthemum or laurel extracts were also confirmed to increase the expression of alcohol dehydrogenase (Table 1), which resulted in alcohol decomposition of the extract It was found to be effective in relieving or improving hangovers due to the promoting effect.

Since the food composition of the present invention can be ingested on a daily basis, it can be expected to relieve or improve a hangover and is very useful.

The food composition of the present invention includes the form of pills, powders, granules, needles, tablets, capsules or liquids, and the food to which the composition of the present invention can be added, for example, various foods, for example, There are beverages, gum, tea, vitamin complexes, and health supplements.

As an essential ingredient that can be included in the food composition of the present invention, other ingredients are not particularly limited except for containing the extract, and various herbal extracts, food supplement additives, or natural carbohydrates can be contained as additional ingredients like conventional food. there is. In addition, the food supplement additives include food supplement additives conventional in the art, for example, flavoring agents, flavoring agents, coloring agents, fillers, stabilizers, and the like.

Examples of the natural carbohydrate include monosaccharides such as glucose, fructose and the like; disaccharides such as maltose, sucrose and the like; and polysaccharides such as conventional sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavoring agents (eg, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used as flavoring agents other than those described above.

In addition to the above, the food composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavoring agents, coloring agents and fillers (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and its salts. salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. In addition, it may contain the flesh for the production of natural fruit juice and fruit juice beverages and vegetable beverages. These components may be used independently or in combination.

Another aspect of the present invention is to provide a health functional food composition for relieving or improving a hangover, comprising as an active ingredient any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract.

The taekran, ginkgo biloba, haedongpi, extract, hangover, relief, improvement are the same as described above.

The health functional food composition for relieving or improving the hangover may further include a milk thistle extract, a pilchar extract, a hocho extract, an arborvitae extract, a creation extract or a laurel extract. At this time, the milk thistle, pilbal, hocho, lateral baekyeop, creation, and laurel are the same as described above.

The term "health functional food or functional food for health" used in the present invention is the same term as food for special health use (FoSHU), and is processed to efficiently exhibit bioregulatory functions in addition to nutrition supply. It means food with high medicinal and medical effects. Here, "function (sex)" means to obtain a useful effect for health purposes such as regulating nutrients or physiological action with respect to the structure and function of the human body. The food of the present invention can be prepared by a method commonly used in the art, and at the time of manufacture, it can be prepared by adding raw materials and components commonly added in the art. In addition, the formulation of the food may be prepared without limitation as long as it is a formulation recognized as a food. The food composition of the present invention can be prepared in various forms, and unlike general drugs, it has the advantage that there are no side effects that may occur during long-term administration of the drug using food as a raw material, and has excellent portability, Food can be consumed as a supplement to enhance the effect of hangover relief or improvement.

Another aspect of the present invention is to provide a pharmaceutical composition for relieving or improving a hangover comprising any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract as an active ingredient.

The taekran, ginkgo biloba, haedongpi, extract, hangover, relief, improvement are the same as described above.

The hangover relieving or improving pharmaceutical composition may further include any one or more selected from milk thistle extract, pilbal extract, hocho extract, arborvitae extract, creation extract and laurel extract. At this time, the milk thistle, pilbal, hocho, lateral baekyeop, creation, and laurel are the same as described above.

The composition comprising the extract of taekran, ginkgo biloba or haedongpi extract of the present invention can be used for relieving, improving, preventing or treating a hangover.

As used herein, the term 'prevention' refers to any action that inhibits or delays the occurrence of a hangover by administering a pharmaceutical composition for relieving or improving a hangover comprising the composition according to the present invention.

As used herein, the term 'treatment' refers to any action in which symptoms of a hangover are improved or beneficially changed by administration of a pharmaceutical composition for relieving or improving a hangover comprising the composition according to the present invention.

The pharmaceutical composition for relieving or improving a hangover of the present invention may further include an appropriate carrier, excipient or diluent commonly used in the manufacture of the pharmaceutical composition.

Specifically, the pharmaceutical composition for treatment is formulated in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, etc., external preparations, suppositories, and sterile injection solutions, respectively, according to conventional methods. can be used for

In the present invention, carriers, excipients and diluents that may be included in the pharmaceutical composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, it is prepared using commonly used diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and these solid preparations include at least one excipient in the extract, for example, starch, calcium carbonate, sucrose ) or lactose, gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid formulations for oral use include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to water and liquid paraffin, which are simple diluents commonly used for suspensions, solutions, emulsions, syrups, etc. there is. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Non-aqueous solvents and suspending agents include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like can be used.

The pharmaceutical composition of the present invention may be administered in a pharmaceutically effective amount, and the term "pharmaceutically effective amount" of the present invention means to treat or prevent a disease at a reasonable benefit/risk ratio applicable to medical treatment or prevention. It means a sufficient amount, and the effective dose level is the severity of the disease, the drug activity, the patient's age, weight, health, sex, the patient's sensitivity to the drug, the time of administration of the composition of the present invention used, the route of administration and the rate of excretion. The duration may be determined according to factors including drugs used in combination with or concurrently with the composition of the present invention and other factors well known in the medical arts. The therapeutic pharmaceutical composition of the present invention may be administered as an individual therapeutic agent or may be administered in combination with other therapeutic agents, and may be administered sequentially or simultaneously with conventional therapeutic agents. and may be administered single or multiple. Taking all of the above factors into consideration, it is important to administer an amount capable of obtaining the maximum effect with a minimum amount without side effects.

The dosage of the pharmaceutical composition of the present invention may be, for example, 0.1 to 500 mg/kg body weight of the pharmaceutical composition for treatment of the present invention administered to animals including humans per day, but is not limited thereto. The frequency of administration of the composition of the present invention is not particularly limited thereto, but may be administered once a day or administered several times in divided doses. The above dosage does not limit the scope of the present invention in any way.

Another aspect of the present invention is to relieve, improve, prevent or treat a hangover, comprising administering the composition to an individual showing or at risk of showing hangover symptoms in a pharmaceutically effective amount of the pharmaceutical composition. provide a way

The hangover, relief, improvement, prevention and treatment are the same as described above.

As described above, any one or more extracts selected from taekran, ginkgo biloba, and haedongpi extract provided in the present invention have a relieving, improving, preventing or therapeutic effect on hangover symptoms, and a pharmaceutical composition comprising the same to relieve, improve hangover , can be used to prevent or treat.

As used herein, the term "individual" means all animals, such as rats, livestock, and humans, that are likely to show hangover symptoms or show hangover symptoms.

In the method of alleviating, improving, preventing or treating hangover symptoms of the present invention, the administration route of the pharmaceutical composition may be administered through any general route as long as it can reach the target tissue. The pharmaceutical composition of the present invention is not particularly limited thereto, but depending on the intended route, such as intraperitoneal administration, intravenous administration, intramuscular administration, subcutaneous administration, intradermal administration, oral administration, intranasal administration, intrapulmonary administration, rectal administration, etc. can be administered through However, since the extract may be denatured by gastric acid during oral administration, the oral composition should be formulated to coat the active agent or to protect it from degradation in the stomach. In addition, the composition may be administered by any device capable of transporting the active agent to a target cell.

Another aspect of the present invention is to provide a quasi-drug composition for relieving or improving a hangover comprising any one or more extracts selected from taekran extract, ginkgo leaf extract and haedongpi extract as an active ingredient.

The taekran, ginkgo biloba, haedongpi, extract, hangover, relief, improvement are the same as described above.

The quasi-drug composition for relieving or improving hangover may further include any one or more selected from milk thistle extract, pilbal extract, hocho extract, arborvitae extract, creation extract and laurel extract. At this time, the milk thistle, pilbal, hocho, lateral baekyeop, creation, and laurel are the same as described above.

The term "quasi-drug" used in the present invention refers to articles that are not instruments, machines, or devices, among articles used for the purpose of diagnosing, treating, alleviating, treating or preventing diseases of humans or animals, and those that are not pharmacological in the structure and function of humans or animals. It refers to articles other than instruments, machines, or devices used for the purpose of influencing, and may include, but is not limited to, preparations for internal use in one embodiment, the formulation method, dose, and method of use of quasi-drugs , components and the like may be appropriately selected from conventional techniques known in the art.

In the present invention, the quasi-drug composition may have a hangover relieving or improving effect, but is not limited thereto.

The quasi-drug composition of the present invention may further include a pharmaceutically acceptable carrier, excipient or diluent if necessary in addition to the above components. The pharmaceutically acceptable carrier, excipient or diluent is not limited as long as it does not impair the effects of the present invention, and includes, for example, fillers, extenders, binders, wetting agents, disintegrants, surfactants, lubricants, sweeteners, fragrances, preservatives, etc. may include

The "pharmaceutically acceptable carrier" may mean a carrier, excipient or diluent that does not inhibit the biological activity and properties of the injected compound without irritating the organism, and specifically, non-naturally occurring carrier). The type of carrier usable in the present invention is not particularly limited, and any carrier commonly used in the art and pharmaceutically acceptable may be used. Non-limiting examples of the carrier include saline, sterile water, Ringer's solution, buffered saline, albumin injection solution, dextrose solution, maltodextrin solution, glycerol, ethanol, and the like. These may be used alone or in mixture of two or more.

The composition comprising a pharmaceutically acceptable carrier may be in various oral or parenteral dosage forms, but preferably oral dosage forms, but is not limited thereto. In the case of formulation, it is prepared using diluents or excipients, such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Specifically, solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and such solid preparations include at least one excipient, for example, starch, calcium carbonate, sucrose, lactose, It may be prepared by mixing gelatin or the like. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid formulations for oral use include suspensions, solutions, emulsions, and syrups. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. there is. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized formulations and suppositories. Non-aqueous solvents and suspending agents include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, Witepsol, Macrogol, Tween 61, cacao butter, laurin, glycerogelatin, etc. may be used.

It was confirmed that the composition comprising one or more extracts selected from the extract of taekran, ginkgo leaf, and haedongpi extract of the present invention as an active ingredient has an alcohol decomposition promoting effect by increasing the expression of alcohol dehydrogenase (ADH) in hepatocytes, In particular, in the case of the combination of taekran, ginkgo leaf and haedongpi extract, a synergistic effect on the alcohol decomposition promoting effect was confirmed. Therefore, the composition of the present invention can be applied to a food composition, a health functional food composition, a pharmaceutical composition, and a quasi-drug composition for relieving or improving a hangover.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are only for illustrating the present invention, and the scope of the present invention is not limited by the following examples.

Example 1: Preparation of extract

5 times 80% ethanol based on the volume of dried ginkgo leaves was added, and extraction was performed at room temperature for 5 days to obtain an extract. The extract was filtered with a filter paper to remove solids, and the remaining liquid was concentrated under reduced pressure to prepare a ginkgo leaf extract.

Other taekran, haedongpi, milk thistle, pilbal, hocho, arborvitae, chrysanthemum or laurel extract were prepared according to the same process as the manufacturing process of the ginkgo leaf extract.

In addition, the stem, root, and fruit parts of the ginkgo biloba were dried, respectively, and prepared according to the same process as the manufacturing process of the ginkgo leaf extract.

Example 2: Confirmation of promotion of ADH production in hepatocytes

In order to confirm that each extract of Example 1 promotes the production of alcohol dehydrogenase, the expression level of ADH was checked after each extract was treated in HepG2 cells.

HepG2 cells were cultured in a 12-well plate using RPMI 1640 medium supplemented with 10% FBS (Fetal Bovine Serum) and 1% antibiotics for 24 hours, and then the medium was exchanged with 1 ml of serum-free RPMI 1640 without FBS per well. and the extracts were treated to be 30 ppm each. After culturing for 24 hours, the expression levels of ADH1A and ADH1C genes were analyzed using real-time PCR.

[Table 1] shows the mRNA expression level of each extract-treated experimental group using the mRNA expression level of the negative control group treated only with ethanol, an extraction solvent, as the standard (1.0).

sample ADH1A expression level ADH1C expression level negative control (ethanol treatment) 1.00 1.00 Ginkgo Leaf Extract 6.12 1.65 taekran extract 1.12 4.25 thawed blood extract 1.02 6.93 Milk Thistle Extract 1.17 3.37 pilbal extract 1.83 7.12 alfalfa extract 1.03 6.62 Arborvitae Extract 2.08 4.95 creation extract 1.02 2.48 laurel extract 1.10 2.81 Ginkgo Stem Extract 1.12 1.15 Ginkgo Root Extract 1.18 1.06 Ginkgo biloba extract 1.21 1.11

As can be seen in Table 1 above, it was confirmed that the extracts of ginkgo leaf, pilbal, and lateral baekyeop increased the expression of ADH1A and ADH1C, and the extracts of taekran, haedongpi, milk thistle, hocho, chrysanthemum and laurel increased the expression of ADH1C.

On the other hand, unlike the ginkgo leaf extract, it was confirmed that the ginkgo stem, root, and fruit extract had little effect on the regulation of ADH1A or ADH1C expression.

Therefore, ginkgo leaf extract, taekran extract, haedongpi extract, milk thistle extract, pilbal extract, hocho extract, arborvitae extract, chrysanthemum extract, laurel extract increase the expression of alcohol dehydrogenase (ADH), which is an alcohol-decomposing enzyme, It was found to be effective in relieving or improving a hangover by promoting it.

Example 3: Preparation of alcohol decomposition promoting beverage

Among the plant extracts of Example 1, ginkgo leaves, taekran, and haedongpi were selected and a beverage for promoting alcohol decomposition was prepared using the same. The beverages of Test Examples 1 to 4 containing each plant extract were prepared by the content shown in Table 2. At this time, the control group was prepared as containing only other components without containing the plant extract.

Test Examples 1 to 4 and the control beverage were mixed/dissolved by adding each component to purified water according to a conventional beverage preparation method, added purified water to make a total of 100 g, and then filled in a brown bottle and sterilized to prepare a beverage.

The plant extract content of each beverage is shown in Table 2 below.

extracts and other ingredients control - sweetener acidulant Purified water Test Example 1 Ginkgo biloba extract (100mg) sweetener acidulant Purified water Test Example 2 Taraxacum extract (100mg) sweetener acidulant Purified water Test Example 3 Thawed blood extract (100mg) sweetener acidulant Purified water Test Example 4 Ginkgo biloba extract (33.3mg)Taekran extract (33.3mg)
Thawed blood extract (33.3mg) sweetener acidulant Purified water

Example 4: Confirmation of alcohol decomposition promoting effect

For adult male subjects, after ingesting 100 mL of the beverage or control beverage of Test Examples 1 to 4 prepared according to Example 3, 17.8% soju was ingested so that the total amount of alcohol was 1.0 g/kg after 2 hours. Immediately after completion of alcohol intake, 100 mL of the beverage of Test Examples 1 to 4 or the control beverage was additionally consumed.

The time when the beverage of the last Test Examples 1 to 3 or the control beverage was consumed was defined as 0 h, and the exhaled alcohol concentration was measured 1, 2, and 3 hours after drinking using a breathalyzer. The results are shown in Table 3.

aerobic alcohol concentration 1 hours 2 hours 3 hours control 0.101 0.086 0.067 Test Example 1 0.086 0.077 0.058 Test Example 2 0.090 0.075 0.061 Test Example 3 0.085 0.073 0.057 Test Example 4 0.076 0.061 0.043

As can be seen in Table 3, when the beverages of Test Examples 1 to 4 including the ginkgo leaf extract, taekran extract or haedongpi extract were consumed, it was confirmed that the aerobic alcohol concentration decreased compared to the control beverage. Specifically, it can be seen that the beverages of Test Examples 1 to 3 containing the extract significantly reduced the alcohol concentration 1 hour or 2 hours after ingestion of the beverage compared to the control beverage. When the drink of Test Example 4 was consumed, it was seen that the alcohol concentration was significantly reduced compared to when the drink of Test Examples 1 to 3 was consumed.

In addition, after 3 hours, the aerobic alcohol concentration of the test example compared to the control group was -0.009, -0.006, -0.010, and -0.024 in Experimental Examples 1 to 4, respectively, and it can be confirmed that the alcohol concentration reduction effect was the greatest in Experimental Example 4. It was confirmed that this corresponds to the synergistic effect of promoting alcohol decomposition by the combination of ginkgo leaf extract, taekran extract and haedongpi extract.

As a result, it was found that the ginkgo leaf extract, the taekran extract or the haedongpi extract can confirm the alcohol decomposition promoting effect, which can help relieve or improve a hangover.

From the above description, those skilled in the art to which the present invention pertains will understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential characteristics thereof. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention, rather than the above detailed description, all changes or modifications derived from the meaning and scope of the claims described below and their equivalents.

Claims (9)

A food composition for relieving or improving a hangover comprising a mixed extract of ginkgo biloba, taekran and haedongpi as an active ingredient.
The food composition of claim 1, wherein the composition further comprises any one or more extracts selected from milk thistle extract, pilbal extract, hocho extract, arborvitae extract, creation extract, and laurel extract. .
The food composition of claim 1, wherein the extract is extracted with a solvent selected from the group consisting _{of water, C 1} to C _{6 alcohols and mixed solvents thereof.}
The food composition of claim 1, wherein the extract promotes alcohol decomposition.
The food composition of claim 1, wherein the extract increases the expression of alcohol dehydrogenase (ADH).
A health functional food composition for relieving or improving hangovers comprising a mixed extract of ginkgo leaves, taekran and haedongpi as active ingredients.
According to claim 6, wherein the composition further comprises any one or more extracts selected from milk thistle extract, pilbal extract, hocho extract, arborvitae extract, creation extract and laurel extract. food composition.
A pharmaceutical composition for relieving or improving a hangover comprising a mixed extract of ginkgo biloba, taekran and haedongpi as an active ingredient.
A quasi-drug composition for relieving or improving a hangover comprising a mixed extract of ginkgo leaves, taekran and haedongpi as active ingredients.