KR101346244B1 - Composition for preventing or relieving alcohol-induced hangover comprising medicinal herbs - Google Patents

Abstract

The present invention relates to a hangover relief composition and alcoholic fatty liver treatment composition comprising a mixed herbal preparation as an active ingredient. Specifically, the composition of the present invention contains black shaft, brown root, dermis, hawthorn, chodugu, bokyeong, Yanggang, sine, creation, thick, licorice, ginger, jujube and flatulose as an active ingredient, administered before or after alcohol intake In this case, by promoting alcohol metabolism in vivo, the blood alcohol concentration can be rapidly lowered, thereby reducing hangover or preventing or treating alcoholic liver disease.

Description

Composition for preventing or relieving alcohol-induced hangover comprising medicinal herbs

The present invention is a composition for preventing or eliminating hangovers, including prevention of alcoholic liver disease, including black shaft, brown root, dermis, hawthorn, chodugu, bokyeong, Yanggang, autograph, creation, ginger, jujube, flatulence, black pepper, and licorice as an active ingredient. Or a therapeutic composition, and a method for producing the same.

Modern people consume excessive amounts of alcohol that can't be digested, resulting in hangover symptoms such as thirst, systemic boredom, fatigue, memory loss, abdominal bloating, indigestion, vomiting, diarrhea and vitamin deficiency. In many cases, the incidence of chronic diseases due to alcohol is also increasing. For example, alcoholic liver disease (liver cirrhosis, fatty liver, liver cancer, etc.), fatigue accumulation due to lactate accumulation, hyperglycemia, alcoholic hepatitis, memory loss, decreased concentration, decreased sensitivity, etc. Causes eggplant lesions.

Hangover refers to headache, diarrhea, anorexia, nausea, vomiting, chills, and cold sweating that occur after drinking alcohol. Objective symptoms include cognition, decreased exercise capacity, hematological changes, and changes in hormones. The cause of hangover is known as dehydration, toxicity of alcohol and alcohol metabolites (acetaldehyde, formaldehyde, acetone, etc.), and nutrient deficiency (blood sugar, vitamin, mineral deficiency) Hangover after drinking alcohol is not only toxicity caused by alcohol itself, but alcohol is transformed into harmful substance in human body during metabolic process and acts as harmful substance to digestive organs including brain and liver. The degree of hangover is very different according to the variation of individuals due to heredity, general condition (nutrition, exercise, dehydration, health).

After drinking alcohol is absorbed in small amounts in the esophagus and oral mucosa, about 10% in the stomach 90% in the small intestine. Alcohol is metabolized through three pathways. When the concentration of ethanol is low, alcohol dehydrogenase and acetaldehyde dehydrogenase, which are present in the gastrointestinal tract or liver, acts on the endoplasmic reticulum. It is metabolized to acetaldehyde and acetic acid by the existing microsomal ethanol oxidizing system (MEOS), and then through the action of catalase present in the peroxisome, carbon dioxide (CO ₂ ) and Final decomposition into water (H ₂ O). When the proper amount of alcohol is introduced, the metabolic system described above works smoothly and does not cause any symptoms caused by alcohol. However, when a large amount of alcohol is introduced, the balance of the metabolic system is destroyed, and thus the homeostasis cannot be maintained. Under these circumstances, the most affected organs are the liver, which in the long term leads to various liver dysfunctions, including fatty liver and cirrhosis, and in the short term results in hangover symptoms such as headache or headache, loss of concentration, heartburn and indigestion. .

Studies on hangover are mostly conducted through animal experiments in Korea, and substantial research is being conducted mainly on human trials abroad. In Japan and the United States, Europe and the United States are actively engaged in the study of toxic substances, toxic agents, and poisoning symptoms of ethanol (methanol). Particularly, since the structure of tetrahydroisoquinoline or tetrahydro-β-carbolines produced as a result of in-vivo metabolism of ethanol is similar to that of morphine, withdrawal symptoms are induced, do. Recently, the metabolism of methanol and formaldehyde in small amount of alcohol (ethanol) has been pointed out as a cause of hangover, and the hangover by alcohol is reported to be due to alcohol metabolism, acetaldehyde, acetone, etc. (Moser J, Bagchi D, Akubue PI, Stohs SJ. Alcohol Alcohol. 28: 287-295, 1993). Most of the alcohol consumed is oxidized and metabolized, so the amount that is not metabolized and excreted is only 2% of the intake amount, and even if the large amount is consumed, it is less than 10%. Therefore, since the acute toxicity by alcohol is attributed to the modification products of ethyl alcohol, acetaldehyde, acetone and other alcohol metabolites, lowering the blood alcohol concentration after drinking may shorten the stay time in the acute poisoning state, It can be said that it has importance.

In connection with the removal of hangover, various formulations of medicaments and health supplements containing compounds extracted from natural or herbal ingredients have been developed which are known to have a beneficial effect in relieving hangovers. The raw materials used are silk fibroin (Korean Patent No. 0528740), Ogapi, Root Root, Chinese Quince, Cherry, Low Head Steel (Registration No. 0528388), Mugwort, Wolfberry, Health, Dermis, Lotus Root, Earth, Worm and Omija (Registration No. 0512912), Astaxanthin, Aspartic Acid (Registration No. 0520985), Persimmon Leaf, Persimmon (Registration No. 0505435), Dermis, Paekbokyeong, Injin, Browning, Brown root (Patent No. 0500373), Asparagus , Green tea, onion, plum (registered patent No. 0496524), ulm (registered patent No. 0462329), soybeans, bean sprouts, grape seed (registered patent No. 455075), active ingredient Hobenodolinol (earthed fruit) 0452128), radish, cedar mugwort, 칡, persimmon leaf, three hundred seconds (registered patent No. 0451013), deckersinol (registered patent No. 0448680), earth, earth tree, hut mixture, reeds, baekshaosoh, cod, peony (Patent No. 0446061), Baek hairy root, Audi, earthenware, brown flower, creation, bokbunja, snakeberry, twig grass, gill core (registration) Huh No. 042771), pine needles (registered patent No. 0412425), brown flower, large thistle seed, taurine, turmeric (registered patent No. 0392876), naringin, naringenin (registered patent No. 0375047), alder, rowan (registered Patent number 081168). The raw materials used in the other patents include horseradish, mushroom, green tea catechin, ogapi, palm cactus (Paekyukcho), Chunma, Rootstock mushroom, Chopstick, Propolis, However, until now, the hangover, food, chewing gum and the like have been developed using the above materials, but the effect is almost outstanding. In addition, a drink containing some herbal medicines may cause systemic boredom, abdominal bloating, vomiting or abdominal pain, etc., and there are problems such as selling at high prices by using expensive herbal medicines.

The liver is one of the most active organs in the human body. The liver is acute or chronic due to various causes such as excessive intake of foods or alcohol containing fat components, infection of viruses, harmful substances such as various medicines, etc. Fatty liver, hepatitis, jaundice, cirrhosis, liver cancer, and the like. In particular, excessive fat or alcohol intake through food causes fatty liver, which accumulates lipids in liver tissue, wherein GOT (glutamate-oxaloacetate transaminase), GPT (glutamate-pyruvate transaminase), and γ-GTP (γ-glutamyl transferase) Will increase. In relation to the mechanism by which chronic ethanol intake causes hyperlipidemia and fatty liver, the metabolism of ethanol by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) increases the liver and intracellular NADH / NAD + ratios. Theorem has been shown to increase fatty acid oxidation and TCA cycle activity in hepatocytes, resulting in fatty liver (Murray RK et al., Haper's Biochemistry, Appleton & Lange, Connechcut, USA. 3rd ed, p260 (1993)).

Alcoholic liver disease is divided into alcoholic fatty liver, alcoholic hepatitis and cirrhosis. Fatty liver is the most common, but sometimes these three diseases may overlap each other, and the severity is mainly related to drinking consumption. Excessive alcohol intake causes fatty liver to accumulate lipids in liver tissue, which increases GOT (glutamate-oxaloacetate transaminase), GPT (glutamate-pyruvate transaminase), and γ-GTP (γ-glutamyl transferase). This accumulation of fat in the liver is caused by increased synthesis of triglycerides in the liver, impaired blood secretion after lipoprotein synthesis, increased liver inflow of free fat from peripheral adipose tissue, but rather a decrease in fatty acid oxidation It is known to become. Alcoholic hepatitis often refers to a condition in which inflammatory reactions and fibrosis of liver tissues occur along with infiltration of fat cells. Further, alcoholic liver cirrhosis progresses when nodules are formed due to necrosis of liver cells and increased degree of collagen deposition. It is easy for anyone to understand that hepatic disease caused by alcohol increases the higher the alcohol consumption and the longer the period, the more the results of the investigation.

Thus, the inventors of the present invention, while continuing to research a new composition having excellent effects on the hangover symptoms and chronic alcoholic liver disease caused by drinking without side effects on the human body, the composition mixed with 13 kinds of herbal medicines other than black shaft is toxic And it was confirmed that the effect of rapidly reducing the blood alcohol concentration without side effects to complete the present invention.

The present invention provides a composition for preventing or eliminating hangover, which comprises black shaft, brown root, dermis, hawthorn, chondura, bokyeong, Yanggang, coriander, creation, ginger, jujube, flatulence, black pepper, and licorice as active ingredients.

The present invention also provides a unit dosage form for preventing or eliminating hangovers containing an effective amount of the composition.

In addition, the present invention is a pharmaceutical composition for the prevention or treatment of alcoholic fatty liver, including black axis, brown root, dermis, hawthorn, chodugu, bokyeong, Yanggang, autograph, creation, ginger, jujube, flatul, pak, and licorice as active ingredients To provide.

The present invention also provides a health functional food and health functional beverage comprising the composition.

In addition, the present invention comprises the steps of drying and cutting black shaft, brown root, dermis, hawthorn, chodugu, bokyeong, Yanggang, cod, creation, ginger, jujube, flatul, bakbak, and licorice; Weighing and mixing the raw materials; Grinding the mixture; And it provides a method for producing the composition, comprising the step of preparing a flour form after feeding the flour paste.

Hereinafter, terms used in the present invention are defined.

The term "alcohol-induced hangover" as used herein refers to alcohol and its metabolites, such as side effects that occur after alcohol consumption, such as fatigue, general boredom, bloating, vomiting, heartburn, and decreased cognitive function. It refers to a combination of clinical symptoms induced by aldehydes.

As used herein, the term "alcohol-induced fatty liver" refers to a condition or disease in which a large amount of fat is accumulated compared to normal liver due to abnormalities in lipid metabolism in the liver due to prolonged alcohol intake.

As used herein, the term "prevention" means any action that inhibits the development or delays the progression of a hangover after ingestion of alcohol by administration of a composition of the present invention.

As used herein, the terms "resolve" and "mitigate" refer to any action that eliminates, significantly alleviates, or ameliorates a clinical symptom or condition resulting from a hangover by administration of a composition of the present invention.

The term "administering" as used herein is meant to provide any desired composition of the invention to a subject in any suitable manner.

As used herein, the term "individual" refers to any animal, including mammals such as humans, monkeys, horses, cattle, pigs, goats, rabbits, or rats, by which the composition of the present invention can improve hangover symptoms. In a preferred embodiment, the subject is a human.

As used herein, the term “effective amount” refers to an amount of a composition sufficient to induce a biological or medical response of an individual, alleviate symptoms, prevent disease, slow or delay disease progression, and the like. This may depend on a variety of factors including the type of disease, severity, activity of the administered substance, sensitivity to the administered substance, time of administration, route and rate of administration, duration of treatment, concomitant medications.

Hereinafter, the present invention will be described in detail.

One aspect of the present invention relates to a composition for preventing or eliminating hangover, which comprises black shaft, black root, dermis, hawthorn, chodogu, bokyeong, Yanggang, coriander, creation, ginger, jujube, flatulence, black pepper, and licorice as active ingredients. will be.

Another aspect of the present invention relates to a pharmaceutical composition for preventing or treating alcoholic fatty liver containing the herbal medicines as an active ingredient.

Pharbitis seed (Purbitis seed) used in the composition of the present invention is a morning glory ( Pharbitis ) of Convolvulaceae nil It is a black seed of Choisy ), which contains about 11% fatty oil and about 2% pharbitin, a resinous glycoside, and it is known to have hypothalamic, diuretic and insecticidal effects by promoting intestinal peristalsis ( KP V Part 2 pp651). In oriental medicine, it has been used for edema, chronic pyelonephritis, ascites due to cirrhosis of the liver.

The root root ( Pueraria lobata Ohwi ) used in the composition of the present invention refers to the root (Puerariae Radix) from which the bark is removed by deciduous broad-leaf tree belonging to the legume. Its main ingredient contains daidzein, daidzin, puerarin and the like. In addition, it contains a triterpenoid compound soyasapogenol A and Kuzusapogenol B, etc. These ingredients are known to have a sedation, hypothermia and vascular relaxation. Brown root is a drug that inhibits fatty liver caused by alcohol (Kwon HJ et al., World J. Gastroenterol. 11 (35): 5512-5516, 2005). Serves to eliminate the disorder (Lee JS. Et al., Clin. Chim. Acta. 347 (1-2): 121-128, 2004).

The dermis used in the composition is citrus unshiu Markovich ) or mature rind of the same plant (Rhusaceae). The dermis contains D-limonene, linalol, linalylacetate, and the flavonoids hesperidin, naringin, porcirin and nobiletin. The dermis has been reported to show antiallergic activity, sedative effect, antiviral activity, serotonin activity and inhibitory effect on liver damage.

Sansa is Hawthorn (Crataegus belongs to the rose family (Rosaceae) pinnatifida Bunge for. Pinnatifida ) is dried fruit. Spherical or obovate, also called hawthorn, pharmacological components include hyperoside, quercetin, and oleanol. The drug is used in stomach, digestion, tonic, high blood pressure, dysmenorrhea, etc.

Alpinia katsumadai is a perennial plant native to tropical regions such as southern China, India, Vietnam, and Malaysia. Anti-inflammatory, anti-pruritic activity with the activity of the extract of Curdula (Jung rat al. J. Dermatol. Sci. 53: 81-84, 2008), antioxidant activity (Lee et al. Phytother. Res. 17: 1041-1047, 2003) , Cholesterol esterase inhibitory effect (Kim et al. Kor. J. Fopod Sci. Technol. 32: 200-205, 200) and the like, as an active ingredient flavonoid compound having a neuronal protective action (Jeong et al. Nat. Prod. Sci. 13: 268-271, 2007), diarylheptanoids with anti-earth action have been reported.

Poria cocos ( Schw .) Wolf is a fungal species that grows on the roots of pines and grows like a hump. White is called Baekbokyeong, and red is called red. Polysaccharide pagamine, a substance in which glucose is linked in a chain, accounts for about 93%, and pagiminic acid and ebricolic acid. Polypotenic acid A, C triterpenoids, elgosterol, lecithin, adenine, choline and the like. It is an herbal medicine that has been used for kidney disease, cystitis, and urethritis due to its tonic, diuretic, and soothing effects.

Yangjiang ( Alpinia officinarum ) is a perennial herb belonging to the family Ginger, which refers to harvesting 4-6 years from late summer to early autumn, especially cutting the roots and drying them in the sun. It contains 0.5 ~ 1.5% of essential oil and its main active ingredients are 1,8-cineol, methyl ester of cinnamic acid, pinene, and cardinene. In addition, flavonoids such as galangin, kaempferid, and alpinin were isolated and identified. Anti-inflammatory and antioxidant activity, pancreatic lipase inhibitory activity (Shin JE et al., 2004), fatty acid synthesis inhibition (Li BH, et al., 2003), 5-alpha reductase inhibitory (Kim YU et al., 2003) Jan; 69 (1) : 72-4.) And the like have been reported.

Autograph ( Ammomum xanthioides Wallich ) is a perennial herb belonging to the Zingiberaceae family. Seeds used as medicinal herb are oval or oval in shape with three dull corners, 15-20 mm long and 10-15 mm in diameter. Known ingredients include essential oils, the main components of which are Borneol, Bornyl-acetate, Linalool, and Nerolidol. Literature Review on the Form and Form, Korean Journal of Herbology, pp. 96-105, 1986).

Creation is Atractylodes belonging to Compositae lancea De Candolle or Atractylodes chinensis Koidzumi ) 's roots have been used mainly as a fire extinguishing agent or a branch medicine. The main components of the production are atractylone, atractylenolide I, II, III, tetrahydroalantocitol, abutenolide B, b-edesmol eudesmol), hinesol and the like. The creation promotes diuresis and sweating by stimulating water metabolism, and is effective in suits. Therefore, it may be helpful for hangover by promoting the excretion of alcohol after drinking.

Ginger ( Zingiber cassumunar Roxb . ) Is a genus of Zingiber belonging to the Zingiberaceae plant. Native to tropical Asia, it is grown mainly in the south of our country. Ginger roots have been used in traditional medicine for the treatment of diseases of the digestive system, central nervous system and osteoarthritis, in addition to lowering blood lipids and sugar levels, antioxidants (Masuda et al., Chem. Lett., 1993), Anti-inflammatory (Jeenapongsa et al., J. Ethnopharmacol., 87, 2003), and pesticidal action (Nugroho et al., Phytochemistry, 41, pp129-132, 1996). Ginger contains essential oils such as zingiberol, α-zingiberene, and sour ingredients such as zingerone, shogaol and 6-gingerol. Trace amounts of microtic substances are high in various bioactive substances, such as 8-gingerol, 10-gingerol, and dehydrozingerone.

Jujube ( Zizyphus jujuba MILL ) is a deciduous broad-leaved arboreous tree of Rhamnaceae. The fruit jujube is edible or medicinal. Especially, the jujube seed is called Sanjoin and is used as a representative medicine for sleep disorder, insomnia, heart anxiety, anxiety, deepening. In addition, the jujube is effective in endocrine diseases, including bronchial asthma, because the anti-allergic component, the extract has a diuretic effect and blood pressure lowering effect. The main components of the fruit are sugars (fructose, glucose, rhamnose), and other organic acids (single acid, malic acid, wine acid, succinic acid, glycolic acid), proteins, vitamins A, B ₂ and C, calcium, phosphorus, etc. It contains.

The Hovenia dulis Thunb is a Rhamnaceae that has been found to contain a large amount of active polysaccharides in fruit pods . Hawthorn fruit (earth) used in the composition of the present invention has the effect of inhibiting carbon tetrachloride-induced liver damage (Hase K et al., Biol. Pharm. Bull. 20 (4): 381-385, 1997 ), Dihydroflavonols, hovenitins I, II and III isolated therefrom have been shown to have inhibitory activity against liver damage caused by alcohol (Yoshikawa M et al., Yakugaku Zasshi 117 (2). ): 108-118, 1997). In addition, it has been reported that the phenolic compounds isolated from the bark fruit have an effect of inhibiting glutamate-induced brain damage (Li G et al., Arch. Pharm. Res. 28 (7): 804-809, 2005). .

Magnolia officinalis Rehd . meat Wils . ) Is a perennial herb belonging to the Magnoliaceae, and the peppermint used in the present invention refers to the root bark, stem bark and branch bark peeled from the bark and dried in the shade between April and June. Thick peppers have been used to treat asthma and gastrointestinal disorders, such as β-eudesmol, magnolol, honokiol, machiol, magnocurarine, and tannins. Contains ingredients. Honokiol is a substance belonging to polyphenol (polyphenol) is used as a useful material that exhibits antidepressant, antithrombotic inhibition, nerve stability, antibacterial effect.

Licorice ( Glycyrrhiza Radix ) is a perennial herb of Legumes soybean (Leguminosae), and the root used in the present invention has a sweet taste and is also used as a sweetener. In addition, herbal medicine, Tibet, India, etc. have been used as a medicine for mitigating and neutralizing the toxicity of medicinal herbs or other herbal medicines for lung diseases and inflammatory diseases. Containing triterpenoid-based saponins, glycyrrhizin and glycyrrhetinic acid, flavonoids liquiritigenin, isoliquiritigenin, liquiritin, and neori Neoliquiritin and the like, as well as isoflavonoids such as glycycestrone, glycyrol, isoglycyrol, licoridin, and the like. Known pharmacological activities include anti-inflammatory, anti-ulcer effect, anti-inflammatory, antipyretic analgesic effect and estrogen activity.

The mixed composition ratio of the herbal medicines used in the composition of the present invention is based on dry weight, 15 to 30 parts by weight of black shaft, 10 to 20 parts by weight, dermis 5 to 15 parts by weight, hawthorn 5 to 10 parts by weight, grass crab 5 to 10 parts by weight, 5 to 10 parts by weight of Fuling, 3 to 6 parts by weight of Yanggang, 3 to 6 parts by weight, 1 to 5 parts by weight, 1 to 5 parts by weight of ginger, 3 to 6 parts by weight of ginger, 3 to 6 parts by weight of jujube, 3 to 4 weight parts It is preferable that they are 6 weight part, 1-5 weight part of thick foils, and 1-5 weight part of licorice. More preferably, the composition ratio is 20 to 25 parts by weight, black root 12 to 15 parts by weight, dermis 8 to 12 parts by weight, hawthorn 6 to 8 parts by weight, 6 to 8 parts by weight of head bean sprouts, Fuling, on a dry weight basis. 6 to 8 parts by weight, mild steel 4 to 5 parts by weight, sine 4 to 5 parts by weight, creation 3 to 4 parts by weight, ginger 3 to 4 parts by weight, jujube 4 to 5 parts by weight, earth 4 to 5 parts by weight, thick foil 3 to 4 parts by weight, and licorice 3 to 4 parts by weight, but is not limited thereto.

The herbal medicines constituting the composition of the present invention are not limited to the raw material itself or its pulverized product, but in various forms, including processed products (eg, powdered), formulated for administration to animals, extracts or juices of the raw materials. May exist.

In one embodiment, the herbal medicines constituting the composition of the present invention may be in the form of a powder prepared by drying and then grinding each raw material. In the present embodiment, the composition in the form of powder is a suitable size after drying the raw materials such as black shaft, brown root, dermis, hawthorn, chodugu, bokyeong, Yanggang, sign, creation, ginger, jujube, earth, bakbak, and licorice Cutting; Weighing and mixing the raw materials; It can be prepared by grinding the mixture. In another embodiment, the composition of the present invention can be prepared in a cyclic form by adding flour paste to the powder mixture prepared as above.

In another embodiment of the present invention, one or more of the herbal medicines constituting the composition of the present invention may be in the form of extract or juice obtained by treating the raw material with an extraction solvent. The extract has a meaning commonly used as a crude extract in the art, but broadly includes a fraction additionally fractionating the extract. As well as those obtained by additionally applying a purification process to the crude extracts or fractions. For example, a fraction obtained by passing the extract through an ultrafiltration membrane having a constant molecular weight cut-off value, a fraction separated by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity), and the like, Fractions obtained through various purification methods. As used herein, the terms "extract" and "fraction" are used broadly to include dilutions or concentrates of the extracts and fractions, dried products obtained by drying the extracts and fractions, or crude purified or purified products of the extracts and fractions. It is used in an absolute sense.

In a further aspect, the present invention provides a method for preparing the hangover composition described above.

The composition of the present invention was found to reduce blood ethanol concentration by about 43% compared to the negative control group after 4 hours of alcohol administration in an animal experiment using ICR mice 30 minutes before 40% ethanol administration (Example 3-1 1, it was confirmed that the acute alcohol administration has the effect of promoting the metabolism of alcohol. In addition, after repeating the composition and 20% ethanol administration once a day for three weeks, blood ethanol concentration was measured. As a result, the blood ethanol concentration was statistically significantly reduced compared to the negative control group. It confirmed that it shows (Example 3-2, FIG. 1). Acute toxicity by alcohol is reported to be due to modified products of ethyl alcohol, acetaldehyde and other alcohol metabolites, so lowering blood alcohol levels after alcohol intake can shorten the time spent in acute poisoning by drinking. . Based on this, the composition of the present invention can relieve hangover symptoms due to alcohol and alcohol metabolites. In addition, the compositions of the present invention may cause rapid metabolism and elimination of alcohol in the blood, contributing to the prevention, alleviation, or treatment of alcoholic liver diseases such as fatty liver, hepatitis, cirrhosis, etc. due to excessive and prolonged alcohol intake. Can be.

In addition, as a result of measuring the weight change of the mice used in the acute and chronic alcohol resolution test, the weight of the test substance administration group compared to the negative control group during the test period was no difference (Example 2, Table 3). Observational changes of general symptoms, symptoms of intoxication, systemic motility and behavioral patterns during the survival period did not show significant changes, and no autopsy findings were found in the major organs after blood collection. . In this embodiment, the composition of the present invention was administered at five times the normal dose, so it is expected that it will be safe and nontoxic even in the excessive range when administered to a mammal.

In addition to the above-mentioned main components, the composition of the present invention may be used as auxiliary ingredients, mineral-containing compounds such as vitamins B, C, E, beta-carotene, Ca, Mg, and Zn, phospholipids such as lecithin, or compounds such as maltol, oligosaccharides, and amino acids. have. In particular, when used by mixing two to three components of vitamin C, E, beta carotene, maltol is more preferable because it can enhance the biological activity. In addition to the above ingredients, in order to enhance the taste as a known additive, natural flavors such as plum, lemon, pineapple or herb, or natural fruit juice, natural pigments such as chlorophyllin, flavonoids, or fructose, sweet sugar Can be mixed with honey, sugar alcohol, sugar and acidulants such as citric acid and sodium citrate.

In another aspect of the present invention, the present invention is an effective amount of a hangover-relieving composition comprising black axis, brown root, dermis, hawthorn, chodugu, bokyeong, Yanggang, sine, creation, ginger, jujube, earthlings, pepper, and licorice It provides a unit dose form containing (unit dose form).

Compositions of the present invention may be formulated in conventional pharmaceutical dosage forms known in the art. The formulations may be formulated and administered in any formulation including, but not limited to, oral, injectable, suppository, transdermal, and non-administered agents. In one embodiment, the unit dosage form of the present invention is a tablet, pill, capsule, sachet, powder, granule, solution, suspension, emulsion, syrup, elixir, extract or aerosol It is a formulation for oral administration such as.

In addition, the unit dosage form may further include a pharmaceutically or physiologically acceptable carrier commonly used according to the dosage form. The carrier may be at least one selected from excipients, diluents, fillers, extenders, binders, lubricants, wetting agents, disintegrants, stabilizers, preservatives, surfactants. The carrier is, for example, lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, Polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.

In one embodiment, the composition of the present invention is a solid dosage form for oral administration and may be in the form of tablets, pills, powders, granules, capsules, sachets and the like. Such solid dosage forms may comprise one or more pharmaceutically or physiologically acceptable excipients, such as diluents, glidants, binders, disintegrants, sweeteners, stabilizers, or preservatives, with the compositions of the present invention. Specifically, lactose, corn starch, gelatin, calcium carbonate, soybean oil, microcrystalline cellulose, or mannitol, magnesium stearate or talc as a lubricant, and polyvinylpyrrolidone or hydroxypropyl cellulose as a binder may be used. have. In addition, as a disintegrant, carboxymethyl cellulose calcium, sodium starch glycolate, potassium polyacrylic acid, or crospovidone, sweetener as white sugar, fructose, sorbitol, or aspartame, stabilizer as carboxymethyl cellulose sodium, beta-cyclodextrin, As lead, or xanthan gum, and preservatives, methyl paraoxybenzoate, propyl paraoxybenzoate, or potassium sorbate may be used.

In another embodiment, the compositions of the present invention are oral liquid formulations, which may be in the form of suspensions, intraocular solutions, emulsions, syrups, elixirs, and the like. In addition to the commonly used simple diluents, water and liquid paraffin, various excipients may be included, for example wetting agents, sweetening agents, fragrances, preservatives and the like. In addition to the above components, natural additives such as natural flavors such as plum flavor, lemon flavor, pineapple flavor and herb flavor, natural fruit juice, natural coloring matters such as chlorophyllin and flavonoid, fructose, honey, sugar alcohol, sugar Or acidic agents such as citric acid and sodium citrate may be mixed and used.

In another embodiment, the compositions of the present invention may be formulated for parenteral administration and include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories, and the like. Injectables may be prepared using a physiologically suitable buffer such as, but not limited to, Hank's solution, Ringer's solution, and physiological saline buffer. In addition, non-aqueous solvents and suspending agents may be used propylene glycol, polyethylene glycol, vegetable oils such as olive oil, injectable esters such as ethyl oleate, and the like, and may further include stabilizers, dispersants, and the like. In addition, the compositions of the present invention may be prepared in powder form and reconstituted with a suitable carrier such as sterile water before use. When formulated as a suppository, bases may include, but are not limited to, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like.

Unit dosage forms comprising a composition of the present invention can be administered to a mammal, such as human, monkey, horse, cow, pig, goat, rabbit or rat, by various routes. All modes of administration can be envisaged, for example oral, intraarticular, intravenous, intramuscular, subcutaneous, transdermal, rectal, nasal, endometrial or intracerebroventricular. The composition may also use other methods known in the art, such as those described in the latest edition of Remington's Pharmaceutical Science. In the most preferred embodiment, the composition may be formulated in unit dosage form for oral administration.

The single human dose of the composition according to the present invention is preferably 3 g to 20 g, but is not limited thereto. Actual dosages may vary depending on the subject's age, weight, severity of symptoms, patient side factors such as alcohol intake, frequency, metabolic rate, responsiveness, and drug side factors such as dosage form, route of administration, duration of administration, It may be appropriately selected by those skilled in the art. In a preferred embodiment, the daily dose of the composition of the present invention may be administered in several divided doses, such that it is 3 g to 20 g, preferably 5 g to 15 g, more preferably about 10 g on an adult basis. .

In a further aspect, the present invention provides a health functional food or health functional beverage comprising the hangover composition and a food acceptable additive. The hangover composition of the present invention may be formulated as a health functional food or a beverage or added to various foods and beverages.

As used herein, the term "health functional food (beverage)" refers to a food (beverage) manufactured and processed using raw materials or ingredients having a useful functionality to the human body, "functional" means a structure and function of the human body. It is designed to exert useful physiological effects such as biological defense, regulation of biological rhythm, prevention of disease, improvement and recovery. The health functional food or beverage of the present invention is caused by hangover symptoms associated with acute and chronic alcohol intake, such as fatigue, general boredom, bloating, vomiting, heartburn, and decreased cognitive function, and other alcohol intakes. Function to prevent, ameliorate, or recover lesions, such as alcoholic liver disease, hyperglycemia, memory loss, decreased concentration, decreased sensitivity, and the like.

In one embodiment, the compositions of the present invention are conventional, including functional foods, nutritional supplements, health foods, food additives, and the like, known in the art. It can be formulated into a kind of dietary supplement. The dietary supplement may also be used in the same manner as the unit dosage form of a medicament, for example tablets, pills, powders, granules, capsules, sachets, elixirs, suspensions, emulsions, solutions, syrups or It may be prepared in a formulation such as aerosol. As the food acceptable acceptable additive, any carrier or additive known to be usable in the art may be used to prepare a formulation to be prepared.

In another embodiment, the present invention provides a health functional beverage containing the composition for relieving hangovers. Such beverages or drinks may be consumed alone after drinking or in addition to alcohol having a high alcohol content before drinking.

The health functional beverage of the present invention may contain a flavoring agent or a natural carbohydrate or the like as an additional component, as in a conventional beverage. The natural carbohydrates include glucose, monosaccharides such as fructose, disaccharides such as maltose and sucrose, and polysaccharides such as dextrin and cyclodextrin, sugar alcohols such as xylitol, sorbitol and erythritol. Flavoring agents may include, but are not limited to, natural sweeteners such as taumartin, stevia extract, or synthetic sweeteners such as saccharin and aspartame. The proportion of said natural carbohydrates is generally from 0.01 to 0.04 g, preferably from about 0.02 to 0.03 g per 100 ml of the composition of the present invention. In addition, the health functional beverage of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants and enhancers, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective properties Colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. These components may be used independently or in combination, and the proportion of the additive is generally selected from the range of 0 to about 20% by weight of the composition of the present invention.

At this time, the amount of the composition in the food or beverage can be appropriately determined according to the purpose of its use (prevention, health, or therapeutic treatment, etc.). In general, the functional food composition may be added in an amount of 0.01 to 15% by weight, preferably 1 to 5% by weight of the total food weight, 0.02 to 10 g, preferably based on 100 ml for the functional food composition May be added in a ratio of 0.3 to 1 g. However, for long term intakes for health control purposes, the amount may be below the indicated range.

All technical terms used in the present invention are used in the meaning as commonly understood by those skilled in the art in the related field of the present invention, unless otherwise defined. Also described herein are preferred methods or samples, but analogs and equivalents thereof are included within the scope of the present invention. The contents of all publications referred to herein are incorporated herein by reference.

The composition according to the present invention, including black shaft, brown root, dermis, hawthorn, chodugu, bokyeong, Yanggang, sign, creation, ginger, jujube, flatul, bakbak, and licorice as an active ingredient, exhibits excellent blood alcohol metabolism promoting effect . The composition of the present invention rapidly reduces blood alcohol concentration when administered prior to alcohol intake, exhibits an effective hangover prevention and elimination effect, contributes to the prevention and treatment of liver disease due to chronic alcohol intake, side effects at concentrations above the normal dose And it does not exhibit toxicity can be usefully used as a beverage and health food for the prevention or improvement of hangover or liver disease caused by alcohol.

1 is a graph showing the effect on the blood concentration change of ethanol when a single or repeated ethanol administration of the composition of the present invention to ICR mice (SA: single dose-negative control, blood collection after 1 hour, SB: single) Dosage-Test Substance-treated group, 1 hour after collection, SC: Single-dose-negative control, 4 hours after-dose, SD: Single-dose-Test Substance administered, 4 hours after blood collection, RA: Repeated-negative control, RB: Repeated tour -Test substance administration group, †: p <0.01 compared to SC group, *: p <0.05 compared to RA group).

Hereinafter, the present invention will be described in more detail with reference to the following Examples and Formulation Examples. However, these examples are only illustrative to aid the understanding of the present invention, and the scope of the present invention in any sense is not limited thereto.

Example  1: Preparation of Hangover Relief Composition

Herbal renaming part Dry weight (g) Black axis Seed 18.75 (5 money) Changwon Root 11.25 (3 money) dermis skin 7.50 (2 money) Sansa Fruit 5.63 (1 and a half) Headlights Fruit 5.63 (1 and a half) Ghost - 5.63 (1 and a half) Yanggang Root 3.75 (1 money) sign Seed 3.75 (1 money) Earth Fruit 3.75 (1 money) ginger Root 3.75 (3 episodes) Jujube Fruit 3.75 (2) Creation Root 2.63 (7 ounces) Thick Bark 2.63 (7 ounces) licorice Root 2.63 (7 ounces)

The medicines listed in Table 1 were prepared in a dry state, which was chopped to a size suitable for weighing. After weighing and mixing each medicine to the indicated weight, the mixture was ground in a conventional manner. The powdered mixture was fed with a paste made of wheat flour and prepared into a ring of about 3 g to 20 g.

Of the above materials, licorice was produced in China, and Hubak was used in Mt. Ulleungdo, and the rest of the materials were domestically purchased and used.

Reference Example  1: Breeding and processing test animals

50 male 6-week-old CrljOri: CD1 Institute of Cancer Research (ICR) mice were acclimated to a laboratory at a temperature of 22 ± 3 ° C, 50 ± 20% relative humidity, and 150-300 Lux roughness for 7 days. It was. During the acclimation period, drinking water was freely ingested with reverse osmosis ultrapure water using the R / O system, and feed with radiation sterilized feed (Purina). It was made.

The test animals consisted of six groups of seven (acute alcohol resolution test) or 11 (chronic alcohol resolution test) as shown in Table 2 below so that the average weight of each group was distributed as evenly as possible by random method on the day of administration. . The tail notation was used to identify individuals during the test.

exam group Population process Blood collection time
Single dose
exam
SA 7 Negative control group After 1 hour SB 7 Test group After 1 hour SC 7 Negative control group After 4 hours SD 7 Test group After 4 hours Repeated administration
exam RA 11 Negative control group - RB 11 Test group -

Reference Example  2: Preparation of Test Substance

As a test material, the composition of the ring (black) form prepared in Example 1 was used, and as a control material, reverse osmosis ultrapure water supplied as a negative water for animal breeding was used. The test substance was set at 0.5 g / kg, which is five times the expected clinical administration concentration (0.1 g / kg), and the composition was adjusted to an appropriate concentration according to the solubility test result for the reverse osmosis ultra pure water. It was prepared by dissolving in.

Ethanol (Merck) was dissolved in the control reverse osmosis ultrapure water, 40% (4g / kg, 5 mL / kg; acute alcohol resolution test) or 20% (2 g / kg, 2.5 mL / kg: chronic alcohol resolution test ) Ethanol solution was prepared. Since it was prepared immediately before administration, no separate analysis such as stability and purity was performed.

Reference Example  3: Statistical Processing

The statistical significance of the results of body weight and serum analysis (ethanol, acetaldehyde) were analyzed by Student's t-test, and the change from the control value was determined to be statistically significant when the p value was less than 0.05. Specifically, when the p value is less than 0.05, ^* and less than 0.01, † was indicated to determine the difference in significance.

Example  2: oral toxicity test

When the composition of the present invention prepared according to Example 1 was orally administered to mice at a 5-fold amount of the clinically planned administration concentration (0.1 g / kg), the clinical symptoms and the weight change compared to the negative control were observed to determine the presence of toxicity and side effects. It was.

Way

For the test animals in each group, the clinical symptoms appearing 30 minutes after administration of the test substance and ethanol containing the composition of the present invention were observed, and in the repeated dose group (chronic alcohol resolution test), continuous observation was performed once daily for 3 weeks. Was carried out. Changes in general condition by drugs, symptoms of intoxication, and death were observed, including changes in skin and hair, eyes and mucous membranes, other respiratory and circulatory systems, autonomic and central nervous systems, systemic motility and behavioral patterns. I was. Particular attention was also paid to tremor, convulsions, softening, diarrhea, drowsiness, sleep and lethargy.

For the repeated dose group, the body weight was measured twice a week after the start of the test and the change is shown in Table 3 below.

To determine the toxicity to organs, anesthesia was performed using an anesthetic (diluted 1/7 with a 5: 1 mixture of Zotilil: Rompun intraperitoneally injected at 6 mg / kg) according to the blood collection time for each group, followed by anesthesia. Therefore, each major organ was observed visually.

result

One of 11 subjects with repeated-negative control (RA) died on the last day of administration, and all other groups survived. As shown in Table 3 below, the weight of the negative control group and the experimental group was analyzed by Student's t-test during the repeated administration period, and there was no statistically significant weight change. Visible and healthy.

After initial administration
Elapsed Days RA ( Negative control group ) RB ( Experimental group ) Population Weight (g) Population Weight (g) 0 11 31.98 ± 1.96 11 31.93 ± 1.96 2 11 32.10 ± 2.00 11 32.01 ± 2.06 6 11 32.77 ± 2.01 11 33.09 ± 2.68 9 11 32.87 ± 1.91 11 32.55 ± 2.51 14 11 33.17 ± 2.32 11 33.37 ± 3.07 16 11 33.54 ± 2.32 11 33.59 ± 3.06 20 10 33.29 ± 2.70 11 34.09 ± 3.32

As a result of clinical symptom observation, all groups of subjects showed drowsiness and staggering for 30 minutes after ethanol administration, but thereafter, no specific clinical symptoms were observed. In addition, no toxic response and other clinical symptoms related to administration of the test substance were observed, and the difference between the experimental group and the control group was not significant in each observation item.

After the blood collection, all the subjects were autopsied and the major organs (heart, liver, lung, spleen, kidney, colon) were visually observed. No abnormalities were found. One repeat dose-negative control group that died during the study was found to have some damage to the liver and digestive system.However, no other abnormalities were found in the same group. Is considered to be an individual clinical symptom.

Example  3: blood alcohol concentration test

In this example, the ethanol and acetaldehyde concentrations were measured by measuring changes in blood ethanol and acetaldehyde when the composition of the present invention was administered to the experimental animals once or repeatedly before ethanol administration.

3-1. Acute Alcohol Resolution Test

Way

Mice adapted for 7 days were distributed into SA, SB, SC and SD groups, 7 per group, as described in Table 2, and fasted 18 hours prior to administration of test substance to eliminate differences in alcohol uptake and degradation by diet. Prior to the administration of alcohol, the composition or the control material (reverse osmosis ultrapure water) of Example 1 was ingested orally to determine the effect on the change in blood alcohol concentration.

The mouse was calibrated with one hand and the test material (0.5 g / kg, 7 mL / kg) prepared in Reference Example 3 was injected into the stomach by oral administration using sonde to the experimental group SB and SD. In the same manner, the negative control group SA and SC group was orally administered the same amount (7 mL / kg) reverse osmosis ultrapure water with the test material. 30 minutes after the administration, 40% ethanol (4 g / kg, 5 mL / kg) was administered once to induce alcohol metabolism.

 After 30 minutes after administration of the test substance, free feeding was performed and sacrificed hourly. That is, according to the blood collection time per group (after 1 hour or 4 hours), anesthesia (diluted 5: 1 mixture of Zotilil: Rompun in 1/7 and intraperitoneally injected at 6 mg / kg) was then anesthetized. Heart blood collection was performed. The obtained whole blood was centrifuged (4 ° C., 4000 rpm, 15 minutes) to separate serum and stored at −80 ° C.

Ethanol concentration analysis was performed using an ethanol measurement kit (R-Biopharm, Germany). Specifically, 3 mL of the reaction mixture (a mixture of potassium diphosphate buffer and NAD) and 0.1 mL of serum were mixed and reacted for 3 minutes, and then absorbance was measured at 340 nm. 0.05 mL of alcohol dehydrogenase was added to the reaction, followed by reaction for 17 minutes, and the absorbance was measured at 340 nm. Using the difference value (ΔA) of the absorbance, the final concentration (C) of ethanol was obtained according to the following equation.

C = ΔA × (V × MG ) / (ε × d × v × 2 × 1000) [g / L]

V = final volume [mL]

c = sample volume [mL]

MW = molecular weight of the analyte [g / mol]

d = light path [cm]

ε = absorbance coefficient of NADH [1 × mmol ^-1 × cm ^-1 ]

    (At 340 nm: 6.3)

Blood acetaldehyde concentration analysis was performed in a similar manner to the above using the acetaldehyde measurement kit (R-Biopharm, Germany). Measured concentrations are expressed as mean ± standard deviation or mean value (Table 4, FIG. 1).

result

group Blood ethanol concentration (g / L) Acetaldehyde concentration in blood (g / L) SA 2.26 ± 0.5 0.00 SB 2.40 ± 0.24 0.00 ± 0.01 SC 1.35 ± 0.7 0.00 ± 0.01 SD 0.77 ± 0.22 0.00 ± 0.01

When blood was collected 1 hour after ethanol administration, the serum ethanol concentration of test substance administration group (SB) was not statistically significant compared to the negative control group (SA). ) Serum concentration was significantly decreased to about 57% than that of the negative control group (SC), showing a statistically significant difference (p <0.01). Therefore, the composition of the present invention was confirmed to improve the rate of ethanol metabolism in the body upon ethanol intake.

Acetaldehyde concentrations in serum were not measured in all groups and therefore are believed to be less than 0.05 g / L, the minimum measurement of acetaldehyde in the acetaldehyde measurement kit used in this test.

3-2. Chronic Alcohol Resolution Test

Way

Mice adapted for 7 days were divided into 11 RA and RB groups as described in Table 2 and fasted 18 hours before the first dose. After oral ingestion of the composition of Example 1 (0.5 g / kg, 7 mL / kg) or control (reverse osmosis ultrapure water) (7 mL / kg), 30 minutes later, 20% ethanol (2 g / kg, 2.5 mL / kg). From day 2, the test substance and ethanol were administered without fasting, and after 30 minutes of fasting, free feeding was performed, and this process was repeated every day for 3 weeks.

After 3 weeks, anesthesia (diluted 5: 1 mixture of Zotiltil: Rompun to 1/7 and intraperitoneally injected at 6 mg / kg) was anesthetized, followed by laparotomy and blood collection. In the same manner as described in Example 3-1, serum was isolated and blood ethanol and acetaldehyde concentrations were analyzed using an ethanol measurement kit and an aldehyde measurement kit (R-Biopharm, Germany) (Table 5 and FIG. One).

result

group Blood ethanol concentration (g / L) Blood aldehyde concentration (g / L) RA 0.61 ± 0.3 0.00 ± 0.01 RB 0.44 ± 0.14 0.00

As shown in Table 5, the blood ethanol concentration of the test substance-administered group (RB) compared to the negative control group (RA) decreased to about 72%, showing a statistically significant decrease (p <0.05). Accordingly, the composition of the present invention was confirmed to have metabolic promoting effects against chronically administered ethanol.

Acetaldehyde concentrations in serum were not measured in all groups and therefore are believed to be less than 0.05 g / L, the minimum measurement of acetaldehyde in the acetaldehyde measurement kit used in this test.

Hereinafter, some formulation examples of medicines, foods and beverages including the composition of the present invention are presented, but the present invention is not limited thereto. The compositions of the present invention are in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, suppositories, and sterile injectable solutions, for example in order to obtain the best possible pharmaceutical preparations, health foods and beverages. It can be prepared in any manner known to the.

Formulation example  1: Preparation of pharmaceutical preparations

1-1. Sanje  Produce

Composition of Example 1 ....... 10 g

Lactose ......................... 1 g

Talc ....................... 10 mg

The above components are mixed and filled in airtight bags to prepare powders.

1-2. Preparation of capsules

Composition of Example 1 ............ 500 mg

Lactose ............... 250 mg

Corn starch ..... 250 mg

Talc ..........................., 6 mg

Magnesium Stearate ............. 5 mg

The above components are mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.

Formulation example  2: manufacture of food

2-1. Preparation of health functional food

Composition of Example 1 ... 1000 mg

Zinc Oxide ......................... 1.5 mg

Magnesium Oxide ......................................... 12 mg

Magnesium Stearate ............... 1.5 mg

PA Color ............................................ 9 mg

Hydroxypropylmethylcellulose ............ 6.8 mg

Glycerin Fatty Acid Ester ...... 0.35 mg

Vitamin B ....................... 30 mg

Vitamin C ................................. 12 mg

Vitamin E .................................. 23 mg

After mixing the above components according to a conventional health food production method, granules may be prepared and used to prepare a health food composition according to a conventional method.

2-2. Solar  Produce

Brown rice, barley, glutinous rice, and yulmu were alphalated by a known method and dried to be roasted, and then ground to a powder having a particle size of 60 mesh. Black beans, black sesame, and perilla were steamed and dried by a known method, and then they were made into a powder having a particle size of 60 mesh by a grinder. The composition prepared according to Example 1 was dried with a hot air dryer and pulverized to a particle size of 60 mesh with a grinder to obtain a dry powder.

The grains, seeds, and dry powders of the compositions of the present invention prepared above were formulated in the following proportions:

Cereals (30 parts by weight brown rice, 15 parts by weight brittle, 20 parts by weight of barley),

Seeds (7 parts by weight perilla, 8 parts by weight of black beans, 7 parts by weight of black sesame seeds),

Dry powder (15 parts by weight) of the composition of the present invention.

Formulation example  3: Manufacturing of beverages

3-1. Preparation of functional drink for hangover

To 15 parts by weight of the composition of Example 1, 0.1 parts by weight of vitamin C, 5.8 parts by weight of fructose, 3.8 parts by weight of white sugar, 0.12 parts by weight of citric acid, 0.03 parts by weight of malic acid, 0.04 parts by weight of sodium citrate, and 0.02 parts by weight of gardenia blue pigment And completely dissolved in the metered water. After stirring and heating at 85 ° C. for about 1 hour, the prepared solution was collected by filtration into a sterilized container, sealed and sterilized, and stored in a refrigerator.

3-2. Manufacture of healthy drinks

15 parts by weight of the composition of Example 1, 0.5 parts by weight of liquid fructose, 2 parts by weight of oligosaccharides, 2 parts by weight of sugar, 0.5 parts by weight of salt, and 75 parts by weight of water were homogeneously blended for instantaneous sterilization, followed by a glass bottle, a plastic bottle, etc. Healthy drinks were prepared by packaging in small packaging containers.

3-3. Manufacture of carbonated drinks

15 parts by weight of the composition of Example 1, 5 to 10 parts by weight of sugar, 0.05 to 0.3 parts by weight of citric acid, 0.005 to 0.02 parts by weight of caramel, and 0.1 to 1 parts by weight of vitamin C and mixed with 79 to 94 parts by weight of purified water A syrup was made, and the syrup was sterilized at 95 to 98 ° C. for 20 to 180 seconds, mixed with cooling water at a ratio of 1: 4, and then carbonated gas was injected at 0.5 to 0.82 parts by weight to prepare a carbonated beverage.

Claims (10)

Black Axis Seed Dry Powder, Root Root Dry Powder, Dermis Bark Dry Powder, Hawthorn Dry Powder, Nutmeg Fruit Dry Powder, Fuling Dry Powder, Yangtze Root Dry Powder, Sine Seed A hangover prevention or elimination composition comprising a dry powder, a rooting powder for drying, a ginger root drying powder, a jujube fruit drying powder, a barley fruit drying powder, a thick gourd bark dry powder, and a licorice root drying powder as an active ingredient. According to claim 1, 15 to 30 parts by weight of black shaft seed dry powder, 10 to 20 parts by weight of root root dry powder, 5 to 15 parts by weight of dermis skin dry powder, 5 to 10 parts by weight of hawthorn dry powder based on the dry weight , 5 to 10 parts by weight of dried nutmeg fruit powder, 5 to 10 parts by weight of Fuling dry powder, 3 to 6 parts by weight of Yangtze root dry powder, 3 to 6 parts by weight of sign seed dry powder, 1 to 5 parts by weight of dried root powder , 3 to 6 parts by weight of ginger root dry powder, 3 to 6 parts by weight of jujube fruit dry powder, 3 to 6 parts by weight of barley fruit dry powder, 1 to 5 parts by weight of thick skin peel dry powder, and 1 to 5 parts by weight of licorice root dry powder A composition comprising a part. The method according to claim 1 or 2, wherein as an auxiliary component, vitamin B ₁ , B ₂ , B ₆ , B ₁₂ , C, pantothenic acid, nicotinic acid amide, folic acid, biotin, zinc, iron, calcium and magnesium At least one, in an amount of 0.01 to 10% by weight, based on the total weight of the composition. The composition of claim 1 or 2, further comprising a pharmaceutically or physiologically acceptable carrier. A unit dosage form for the prevention or resolution of hangovers, comprising the composition according to claim 1 in an amount of 3 g to 20 g. A unit according to claim 5 in the form of tablets, pills, powders, granules, capsules, sachets, elixirs, solutions, suspensions, emulsions, syrups, extracts, or aerosols. Dosage Forms.  Health functional food for preventing or eliminating hangover, comprising the composition of claim 1.  Health functional beverage for preventing or eliminating hangover comprising the composition according to claim 1. Dried and cut raw materials such as black shaft seed, root root, dermis peel, hawthorn fruit, green bean fruit, bokyeong, lamb's eye root, cod seed, creation root, ginger root, jujube fruit, flatulite fruit, pepper husk, and licorice root step; Weighing and mixing the raw materials, respectively; Grinding the mixture; And adding a flour paste to the mixture to prepare a cyclic form. The composition according to claim 1 or 2, wherein the composition has a long-term blood alcohol lowering effect.

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