KR101034986B1 - Composition comprising the mixed herbal extract for relieving hangover - Google Patents

Abstract

PURPOSE: A composition containing mixture herb extract for relieving hangover is provided to promote ADH activity and to relieve hangover. CONSTITUTION: A composition for relieving hangover contains water, ethanol, or ethanol solution extract of 1-3 weight parts of Oenanthe javanica, 1-3 weight parts of Pueraria lobata (Willd.) Ohwi, and 1-3 weight parts of Curcuma aromatica. A health food for relieving hangover contains concentrate of the extract as an active ingredient. A method for preparing the composition comprises: a step of extracting Oenanthe javanica, Pueraria lobata (Willd.) Ohwi, and Curcuma aromatica in water, ethanol, or ethanol solution at 90-100°C for 1-5 hours; a step of filtering the extract; a step of decompressing the extract; and a step of drying the concentrate.

Description

Composition comprising the mixed herbal extract for relieving hangover

The present invention relates to a hangover relief composition, and to a hangover relief composition and health functional food containing buttercups, brown root and turmeric.

Metabolism is a chemical reaction in living organisms that converts normally ingested substances into other compounds (metabolites). In addition to digesting and breaking down the foods we use as nutrients, we also include metabolic changes between components of the three major nutrients (carbohydrates, proteins and fats) as needed. In the case of substances coming from outside, metabolites that are more toxic than the original are sometimes produced after metabolism, causing harm to body tissues. Alcohol (alcohol) is well dissolved in water, after drinking it is absorbed by the gastrointestinal tract and distributed through the bloodstream to the tissues of the body, including the brain and liver. Alcohol transported to the liver through the bloodstream is oxidized by an enzyme called alcohol dehydrogenase (ADH) to be acetaldehyde, and then oxidized by aldehyde dehydrogenase (ALDH) to acetic acid. Both of these enzymes use a coenzyme called NAD, which produces NADH and H +. Alcohol converted to acetic acid is transported to each tissue, oxidized (metabolized) and converted to carbon dioxide (CO ₂ ) and water (H ₂ O) via acetyl CoA. Some (about 20%) alcohol is metabolized by an alcohol-induced cytochrome P450 (CYP2E1) enzyme in which only the liver microsomes (vesicles) are present, and then metabolized to acetic acid via acetaldehyde. Alcohol that is not metabolized in the liver remains in the blood and is released into the breath (breath), skin, or urine (Urine). Alcohol is only metabolized every hour, regardless of intake or blood levels. It is metabolized depending on the amount of alcohol dehydrogenase, aldehyde dehydrogenase, and alcohol-induced cytochrome P450 (CYP2E1), which are mainly present in each human liver. The titer or concentration of these enzymes is determined by genetic information or environmental factors of the individual, which may be affected in some ways by the individual's gender, age, weight, nutritional status and physical condition.

For example, young and strong men can metabolize alcohol much faster than older men and women. In fact, women who drink the same amount of alcohol have a higher blood alcohol concentration (BAC) in women, which is reported to cause more tissue damage to the liver, brain or heart than men. In this case, the average body weight of women is lower than that of men, because the amount of alcohol enzymes in the liver and the water content of the body is less, so the alcohol blood concentration is higher than the alcohol distribution.

Some Asians, including Koreans (about 20-40%, including Chinese and Japanese), have genetically different mutations in ADH or ALDH enzymes. In particular, among the ALDH2 enzymes involved in acetaldehyde metabolism, glutamic acid is mutated to an amino acid called lysine, which significantly reduces the titer of this enzyme. They have flushing acetaldehyde even after a drink, causing the flushing to look red. These people are more cautious because they are known to drink more alcohol because of the coercive atmosphere of their surroundings, which accumulates toxic acetaldehyde in the living body and reacts with the polymer proteins in the living body, which adversely affects their own functions. Should be.

On the other hand, Oenanthe javanica is a perennial plant of the dicotyledon type Asteraceae, which grows in marshes and grows in paddy fields. Buttercup clears the blood and contains high amounts of antioxidants such as quercetin and camphorol, which inhibits the production of free radicals in the body, reducing the inflammation of the cells, as well as preventing breast cancer, colon cancer, ovarian cancer and stomach cancer. There is also. Buttercup is excellent detoxification, blood pressure lowering action is good for hypertensive patients, and contains a lot of dietary fiber detoxify harmful substances, has the effect of removing sputum. In addition, vitamins A, B, and C are evenly contained, especially vitamin A. In addition, it stimulates appetite, lowers blood pressure, and is rich in fiber, which stimulates the inner wall of the intestine to promote bowel movements, thereby relieving constipation.

The root of Pueraria lobata (Willd.) Ohwi is the root of the perennial deciduous plant belonging to the legume, which contains puerin, beta-sitosterol, alacchinic acid and a lot of starch. As an antipyretic, it can be used to treat high fever, headaches, create essences, quench thirst, and sweat and cure fever, but it is also used for many other symptoms. In addition, it is used for indigestion, headache, anemia, dysentery, abdominal pain, alcohol poisoning, cold, etc., and is used as a gastrointestinal drug in the civilian.

Curcuma aromatica is a perennial herb that is a monocotyledonous plant, Ginger neck, also known as spring turmeric. Turmeric has a spicy, bitter taste and is used as a pepper-like spice, and because of its golden scarlet color, it is also used to dye food yellow. The yellow color is due to a pigment called curcumin, which is effective in destroying free radicals to prevent aging and prevent dementia, and to increase cognitive abilities by removing free radicals and harmful substances accumulated in the brain of patients with dementia. In Chinese medicine, turmeric is used as a blood circulation disorder treatment because it removes fish blood and promotes blood circulation. In addition, it is used to relieve menstrual pain, shoulder joint pain, bruises, and high blood pressure.

Therefore, various foods containing buttercups, brown roots or turmeric having the above effects have been developed, and in particular, Korean Laid-Open Patent Publication No. 2008-35853 discloses a hangover-relieving composition using the extract of hot water and extracts of the parsley as an active ingredient. Food composition having the effect of treating or preventing a hangover by promoting the metabolism of alcohol and acetaldehyde in blood to reduce the physiological side effects of the hangover by preparing a functional health food using the same, and Korean Patent Publication No. 2010-50032 No. Calcium ion fertilized brown rice, black bean, mung bean, brown root, browning, parsley, alcohol excretion and acetaldehyde metabolism and hangover resolving ability, Korea Patent Publication No. 2010-26487 jujube, turmeric ), Licorice, persimmon soup, brown root, etc., are extracted with hot water and filtered to remove solids. Manufactured hangover drink, Korean Registered Patent No. 514442 is prepared by mixing fructose, aspartic acid, taurine with a mixed extract of the bark fruit, brown root, buttercup, pumpkin, etc. Korean Patent Laid-Open Publication No. 2009-78662 discloses a calcium compound as a main ingredient, and extracts black bean, green bean, red bean bean, red bean, red root, licorice, ume, etc. using alcohol or hot water as a solvent, and extracts sugar or glucose. And hangover resolution composition having excellent effect in promoting alcohol decomposition and resolving hangover by dissolving maleic acid, lactic acid or salt thereof, Korean Patent No. 706465 is obtained by mixing a lactic acid bacteria culture medium and turmeric powder and fermenting them in a culture tank. Hangover horn prepared by using the resultant as a main ingredient and additional compositions for hangover elimination Drinks, Korea Patent No. 181168 discloses the alder extract and extract yeojeongsil Rowan extract, Puerariae Radix extract to a screeching prepared by adding the extract of watermelon plants, such as natural tea are posted.

However, as described above, hangover relief composition containing both buttercups, brown root and turmeric has not been developed.

Therefore, the present inventors have studied the composition for hangover relief, and as a result, the composition containing all of the buttercups, brown roots and turmeric promotes the alocohol dehydrogenase (ADH) activity compared to the respective compositions containing the buttercups, brown roots or turmeric. It was confirmed that it is effective in relieving hangover because it is rapidly decomposed and completed the present invention.

Therefore, the problem to be solved by the present invention is to provide a hangover relieving composition and health functional food with excellent hangover ability to break down alcohol by mixing and extracting parsley, brown root and turmeric.

Hangover composition according to the present invention to solve the above problems comprises 1 to 3 parts by weight of parsley, 1 to 3 parts by weight and 1 to 3 parts by weight of turmeric water, ethanol or ethanol aqueous solution extract.

The water, ethanol or ethanol aqueous solution used in the extraction of buttercup, brown root and turmeric may be 1 to 10 times (v / w) of the amount of buttercup, brown and turmeric, preferably 5 to 10 times (v / w). .

The hangover composition,

1 to 3 parts by weight of buttercup, 1 to 3 parts by weight of brown root and 1 to 3 parts by weight of turmeric with water, ethanol or an aqueous solution of ethanol at 90-100 ° C. for 1-5 hours (1 step);

Filtering the extract extracted by heating in the first step (step 2);

Concentrating the extract filtered in the second step under reduced pressure (3 steps); And

Drying the extract concentrated under reduced pressure in step 3 (step 4);

It includes.

The two steps of filtering the heated extract may include filtering using an ultrafilter, and may be filtered by a filtration method commonly used in the art.

The three steps of concentrating the filtered extract under reduced pressure may include concentrating using a reduced pressure concentrator, and may be concentrated by a concentration method commonly used in the art.

The four steps of drying the concentrated extract under reduced pressure may include a step of drying using a lyophilizer, and may be dried by a drying method commonly used in the art.

The water, ethanol or turmeric extract of buttercup, brown root and turmeric may be further fractionated using one or more solvents selected from the group consisting of n-hexane, methylene chloride, acetone, ethyl acetate and n-butanol. The preparation temperature of the fraction fractionated by using an additional solvent to the extract or extract may be 20 to 50 ℃, but is not limited thereto. Extraction time is not particularly limited, but is preferably extracted within 10 minutes to 1 day, and the extraction device may be a conventional extraction device, ultrasonic grinding extractor or fractionator. The extract thus prepared may be removed by hot air drying, reduced pressure drying, and / or lyophilization, but is not limited thereto. Preferably, the extract may be dried under reduced pressure to remove the solvent.

Compositions comprising extracts of buttercups, brown roots and turmeric of the present invention may further comprise suitable carriers, excipients or diluents according to conventional methods. Examples of carriers, excipients and diluents that can be included in the composition of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, Cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. Compositions comprising extracts according to the invention are each formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories or sterile injectable solutions according to conventional methods. Can be used. In detail, when formulated, it may be prepared using diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, surfactants, etc. which are commonly used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and the solid preparations include at least one excipient such as starch, calcium carbonate, sucrose, lactose, gelatin, and the like. Can be prepared by mixing. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral use include suspensions, solvents, emulsions, and syrups.In addition to the commonly used simple diluents, water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.

The composition comprising the buttercups, brown root and turmeric extract of the present invention can be used in a variety of food and beverages for hangover relief. Foods to which the extract of the present invention may be added include various foods, for example, beverages, gums, teas, vitamin complexes, dietary supplements, and the like, which are pills, powders, granules, tablets, tablets, capsules or beverages. Available in form. At this time, the amount of the extract in the food or beverage, in general, may be added to 0.01 to 15% by weight of the total food weight in the case of the health food composition of the present invention, 0.02 to 10g, based on 100ml for the health drink composition, preferably It may be added at a ratio of 0.3 to 1g. The health beverage composition of the present invention has no particular limitation on the liquid component except for containing the extract as an essential ingredient in the indicated ratio, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks.

Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; Polysaccharides such as dextrin, cyclodextrin; Conventional sugars such as and the like and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those described above, natural flavoring agents (tauumatin, stevia extract, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of said natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention. In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like.

The compositions of the present invention may also contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical, but is generally selected in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.

The composition comprising the extract of Buttercup, Carrot and Curcuma of the present invention is effective in promoting the activity of ADH, a liver enzyme related to alcohol metabolism, which is a side effect of alcohol consumption, thirst, headache, general boredom, fatigue, memory loss and vomiting. The effect of improving the hangover phenomenon, etc. can be seen.

In addition, parsley, brown root and turmeric extracts can rapidly decompose ethanol into acetic acid, the final metabolite by activating ADH, a liver enzyme involved in alcohol metabolism, thereby reducing liver damage from alcohol intake. In addition, gastritis, pancreatitis, high blood pressure, It can help to improve diseases caused by alcohol consumption such as stroke and esophagitis.

1 is a process chart sequentially showing the manufacturing process of the hangover relief composition according to the present invention.
Figure 2 shows the effect of lowering the blood alcohol concentration of the hangover relief composition.

Hereinafter, preferred embodiments of the present invention will be described. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms.

Example 1 Preparation of Hangover Relief Composition

100 g of buttercup, 100 g of brown root and 100 g of turmeric were added to 1.5 L of purified water and extracted by heating at 100 ° C. for 3 hours, followed by filtration using an ultrafilter. The filtrate was concentrated in a vacuum condenser, and then dried in a lyophilizer to prepare a hangover composition.

Example 2 Preparation for Hangover Relief

In the same manner as in Example 1, but instead of purified water to prepare a hangover composition for 1.5L ethanol.

<Examples 3-8> Preparation for Hangover Relief

In the same manner as in Example 1, but under the same conditions as in Table 1, 5 times the volume of purified water of parsley, brown root and turmeric was added to prepare a hangover composition of Examples 3-8.

<Comparative Examples 1-9> Preparation of Comparative Composition

In the same manner as in Example 1, but under the same conditions as in Table 1, the composition of Comparative Examples 1 to 9 by preparing purified water having a capacity of 5 times the total weight of buttercups, roots and turmeric.

division Buttercup (g) Brown root (g) Turmeric (g) Example 1 100 100 100 Example 2 100 100 100 Example 3 42 129 129 Example 4 129 42 129 Example 5 129 129 42 Example 6 180 60 60 Example 7 60 180 60 Example 8 60 60 180 Comparative Example 1 250 25 25 Comparative Example 2 25 250 25 Comparative Example 3 25 25 250 Comparative Example 4 300 - - Comparative Example 5 - 300 - Comparative Example 6 - - 300 Comparative Example 7 150 150 - Comparative Example 8 150 - 150 Comparative Example 9 - 150 150

Experimental Example 1 Measurement of ADH Activity of Hangover Relief Composition

ADH activity measurement experiments of the compositions prepared in Examples 1 to 8 and Comparative Examples 1 to 9 were performed.

Using the alcohol and acetaldehyde analysis kit, the compositions of Examples 1-8 and Comparative Examples 1-9 were dissolved in distilled water at a concentration of 1 mg / ml, respectively, and the amount of NADH produced as a reaction product of the treated group and the control group (drinking water) was used. Absorbance was measured at 340 nm using an UV spectrophotometer. The activity of each composition was measured using an in vitro assay system and expressed as a relative rate relative to the control. The experimental results are shown in Table 2 below.

division in vitro results (1 mg / ml) ADH activity (%) Example 1 149 Example 2 140 Example 3 139 Example 4 138 Example 5 138 Example 6 140 Example 7 133 Example 8 134 Comparative Example 1 117 Comparative Example 2 113 Comparative Example 3 114 Comparative Example 4 95 Comparative Example 5 82 Comparative Example 6 89 Comparative Example 7 94 Comparative Example 8 94 Comparative Example 9 92 Control group (drinking water) 100

As shown in Table 2, the compositions of Examples 1 to 8 prepared from buttercups, brown roots and turmeric are Comparative Example 4 containing only buttercups, Comparative Example 5 containing only brown roots and the composition of Comparative Example 6 containing only turmeric It showed higher ADH activity.

Therefore, the compositions prepared by mixing 1-3 parts by weight of parsley, 1-3 parts by weight and 1-3 parts by weight of turmeric in Examples 1 to 8 according to the present invention increase synergistic ADH activity compared to each of these herbal compositions. The effect was confirmed to be excellent.

Experimental Example 2 Determination of Blood Alcohol Concentration of Hangover Relief Composition

Blood alcohol concentration decrease measurement experiments of the compositions prepared in Example 1 and Comparative Examples 4-6.

The rats used in the experiment were Sprague-Dawley male rats (6 weeks old, body weight 180 ~ 200g) and were used after 7 days of adaptive breeding. The breeding temperature was 22 ± 2 ℃ and the lighting time was 12 hours (8: 00 ~ 20: 00), and solid feed (super feed) and water were freely given up to 12 hours before the experiment.

The compositions prepared in Example 1 and Comparative Examples 4 to 6 were dissolved in drinking water in an amount of 1.5 g / kg, respectively, and orally administered to 1 ml of the test subject rats. 808 (Grammy, Inc.) was orally administered to the test subject rats. 30 minutes after oral administration, 1 ml of 40% aqueous ethanol solution was orally administered. Serum was obtained by taking 0.2 ml of blood from the subclavian vein before and after administration of 40% aqueous ethanol solution and at 1, 2 and 4 hours. The absorbance was measured at 570 nm after reacting with EnzyChrom Ethanol Assay Kit. The experimental results are shown in Table 3 below.

division Blood alcohol level (%) 1 hours 2 hours 4 hours Example 1 0.050 0.077 0.002 Comparative Example 4 0.110 0.100 0.020 Comparative Example 5 0.160 0.137 0.035 Comparative Example 6 0.130 0.140 0.030 Control group (drinking water) 0.127 0.120 0.020 Positive Control Group (Dawning808) 0.087 0.099 0.014

As shown in Table 3, the composition of Example 1 prepared with buttercups, brown roots and turmeric is less than the composition of Comparative Example 4 containing only buttercups, Comparative Example 5 containing only roots and Comparative Example 6 containing only turmeric The alcohol concentration was significantly decreased over time, and the effect of reducing the alcohol concentration in the blood was higher than that of the positive control group (dawn 808).

Therefore, in Example 1 according to the present invention, the composition prepared by mixing 1-3 parts by weight of parsley, 1-3 parts by weight and 1-3 parts by weight of turmeric was found to have an excellent effect of lowering blood alcohol concentration.

Experimental Example 3 Evaluation of Hangover Relief Effect of Hangover Relief Composition

The hangover relief effect of the compositions prepared in Example 1 and Comparative Examples 4 to 6 was evaluated.

80 adult men in their 20s were included, and the test subjects (80 persons) ingested 300 ml of commercial soju (20% alcohol), and after 30 minutes, the composition prepared in Examples 1 and Comparative Examples 4-6 was 0.15. It was dissolved in drinking water in the amount of g / ㎏ and divided into 4 groups of 20 people each was ingested 75ml. The hangover elimination effect was evaluated by the 7-point scale according to the degree of headache and thirst, which is a hangover phenomenon caused by drinking the next day.

<Evaluation Criteria>

Headache thirst

1: very severe headache 1: very thirsty

3: a little headache 3: little thirst

5: almost no headache 5: almost no thirst

7: no headache 7: no thirst

division headache thirst Example 1 6.6 6.7 Comparative Example 4 3.6 3.5 Comparative Example 5 3.3 3.2 Comparative Example 6 3.5 3.4

As shown in Table 4, the composition of Example 1 prepared with buttercups, brown roots and turmeric is less drunk than the composition of Comparative Example 4 containing only buttercups, Comparative Example 5 containing only roots and Comparative Example 6 containing only turmeric It has been shown to have high headache and thirst quenching effects.

Therefore, the composition prepared by mixing 1 to 3 parts by weight of parsley, 1 to 3 parts by weight and 1 to 3 parts by weight of turmeric in Example 1 according to the present invention was found to be excellent in the hangover phenomenon improvement effect when drinking.

Experimental Example 4 Acute Oral Administration of Rats

Acute toxicity test was performed using 6-week-old SPF SD rats as follows. Two animals per group were dissolved in the buttercups, roots and turmeric compositions of Example 1 of the present invention and administered orally at a dose of 1 g / kg / ml. After administration of the composition, the mortality, clinical symptoms, and weight changes of the animals were observed. Hematological and hematological examinations were performed. The necropsy was performed to visually observe the abdominal and thoracic organ abnormalities. As a result, no significant clinical symptoms or dead animals were noted in all animals treated with the test substance, and no toxic changes were observed in weight changes, blood tests, blood biochemical tests, and autopsy findings. Therefore, the composition according to the present invention did not show a change in toxicity in all rats up to 5,000 mg / kg and the minimum lethal dose (LD 50 value) was determined to be a safe substance of more than 5,000 mg / kg.

Production Example 1 Production Example of Powder

30 mg hangover relief composition of Example 1

Lactose 100mg

Talc 10mg

The above ingredients are mixed and filled in an airtight cloth to prepare a powder.

Preparation Example 2 Preparation of Tablet

100 mg of hangover composition of Example 1

Corn Starch 100mg

Lactose 100mg

2 mg magnesium stearate

After mixing the above components, tablets are prepared by tableting according to a conventional method for preparing tablets.

Production Example 3 Production Example of Liquid

300 mg of hangover composition of Example 1

10 g of isomerized sugar

Mannitol 5g

Purified water

According to the conventional method of preparing a liquid solution, each component is added to the purified water to dissolve it, and lemon flavor is added thereto, then the above ingredients are mixed, adjusted to 100 ml by adding purified water, and then filled into a brown bottle and sterilized to prepare a liquid solution. do.

Production Example 4 Production Example of Health Food

1000 mg hangover relief composition of Example 1

70 μg of vitamin A acetate

Vitamin E 1.0mg

Vitamin B1 0.13mg

Vitamin B2 0.15mg

Vitamin B6 0.5mg

0.2 µg of vitamin B12

Vitamin C 10mg

10 μg biotin

Nicotinamide 1.7mg

Folate 50 ㎍

Calcium Pantothenate 0.5mg

Mineral mixture

Ferrous Sulfate 1.75mg

Zinc Oxide 0.82mg

Magnesium Carbonate 25.3mg

15 mg potassium monophosphate

Dicalcium Phosphate 55mg

Potassium Citrate 90mg

Calcium Carbonate 100mg

Magnesium chloride 24.8mg

The composition ratio of the above-mentioned vitamin and mineral mixtures is composed of relatively suitable ingredients for health foods as a preferred formulation, but the formulation ratio may be arbitrarily modified, and the above ingredients may be mixed according to a general health food manufacturing method. The granules may be prepared and used for preparing a health food composition according to a conventional method.

Preparation Example 5 Preparation of Healthy Drinks

1000 mg hangover relief composition of Example 1

Citric Acid 100mg

Oligosaccharide 100g

Plum concentrate 2g

1 g of taurine

Add 900 ml of purified water

After mixing the above components according to a conventional healthy beverage production method, and then stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained by sterilization in a sterilized 2 L container, sealed sterilized and then stored in the present invention For the preparation of healthy beverage compositions.

Although the composition ratio is a composition suitable for a preferred beverage in a preferred formulation example, the compounding ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, and use purpose.

Claims (3)

delete 1 to 3 parts by weight of parsley, 1 to 3 parts by weight and 1 to 3 parts by weight of turmeric, water, ethanol or ethanol or health functional food for hangover relief, characterized in that it comprises a concentrate of an aqueous solution of ethanol. 1 to 3 parts by weight of buttercups, 1 to 3 parts by weight of roots and 1 to 3 parts by weight of turmeric, at 90 to 100 ° C with 5-10 times (v / w) water, ethanol or ethanol aqueous solution of buttercups, roots and turmeric Heating extraction for 5 hours (step 1);
Filtering the extract extracted by heating in the first step (step 2);
Concentrating the extract extracted in the second step under reduced pressure (3 steps); And
Drying the extract concentrated under reduced pressure in step 3 (step 4);
Method for producing a health functional food for hangover relief comprising a.

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