KR102197395B1 - The process of making healthcare composition for relieving and preventing alcoholic hangover comprising fermented Dendropanax morbifera extract and Capsosiphon fulvescens extracts - Google Patents

Abstract

The present invention enhances the pharmacological activity of Hwangchil trees by fermenting Hwangchil tree leaves and branches that have various physiological activities such as hangover relief, fatigue recovery, hepatocyte protection, antidiabetic, antioxidant, and immunity enhancement as our own plant resources. Fermented extract of Hwangchil tree contains a large amount of various inorganic salts such as iron, potassium, iodine, vitamins A, C, etc., which relieves hangover, prevents gastric ulcer or duodenal ulcer and sedates, lowers cholesterol, promotes children's growth and treats constipation. The Hwangchil Tree, which has the effect of such as mesaengi extract, is mixed and formulated so that it can complementaryly synergize each other without loss of physical properties or loss of active ingredients. It relates to a method of preparing a complex fermented extract for relieving a hangover in which a fermented extract and a meesengi extract are mixed.

Description

The process of making healthcare composition for relieving and preventing alcoholic hangover comprising fermented Dendropanax morbifera extract and Capsosiphon fulvescens extracts}

The present invention relates to a method for preparing a hangover-relieving complex fermented extract in which a fermented extract of Hwangchil tree and a fermented extract of Maesengi are mixed,

In more detail, the pharmacological activity of Hwangchil tree is enhanced by fermenting Hwangchil tree leaves and branches that have various physiological activities such as hangover relief, fatigue recovery, liver cell protection, anti-diabetes, antioxidant activity, and immunity enhancement. As the fermented extract of Hwangchil tree contains a large amount of various inorganic salts such as iron, potassium, iodine, vitamins A and C, etc., it has the effect of relieving hangover, preventing and sedating gastric ulcers or duodenal ulcers, reducing cholesterol and treating constipation. By mixing and forming the extracts of meesisengi to complement each other without loss of physical properties or loss of active ingredients, the function is enhanced in a complex manner to realize an enhanced effect than the original pharmacological effect. It is a health functional composition for hangover relief with improved alcohol decomposition activity of a new composition that has not been used in a conventional combination while having excellent efficacy to effectively prevent a hangover from occurring. It relates to a method for preparing a mixed composition for relieving hangover complex extract.

Alcohol is a beverage that is widely used regardless of East and West, but when excessive intake not only harms individuals in terms of mental or physical aspects, but also causes various social problems. The trend is to avoid frequent drinking.

Therefore, due to the nature of drinking culture, which is easy to drink too much, most general drinkers complain of various discomforts such as headache, fatigue, and vomiting due to hangover the next day after drinking. Hangover refers to uncomfortable physical and mental symptoms that appear between 8 to 16 hours after drinking alcohol. It is caused by the action of acetaldehyde, which occurs when alcohol is decomposed. The main symptoms are headache, gastrointestinal sensation, vomiting, dizziness, and It reduces work efficiency due to muscle pain, and causes social and economic losses by having various negative effects on normal life. Therefore, because of this problem, interest in drinks or drugs that can eliminate hangovers is increasing.

In particular, symptoms such as hangover and memory impairment appear when drinking excessively because acetaldehyde, which is not completely decomposed during alcohol metabolism, remains in the body and stimulates the cerebellum and cerebrum. Alcohol is more fatal to the brain than to the liver. Research is being actively conducted to alleviate hangovers and diseases mainly caused by brain problems, such as memory loss caused by drinking, headache and dizziness, and anger control disorder.

Hangover is a group of symptoms that occur after metabolism is completely finished after ingesting alcohol. Symptoms are largely divided into physical symptoms and mental symptoms. The physical symptoms of hangover include headache, fatigue, sensitivity to stimulation, diarrhea, loss of appetite, vomiting, and tremor, and mental symptoms include dizziness, decreased work ability and cognitive function, depression, anxiety, and excitement. As a cause of hangover, acetaldehyde, an alcohol metabolite, acts as a major toxic substance, and it has been reported that a large amount of free radicals are generated in the process of alcohol metabolism, which causes alcoholic disorders.

GABA (gamma-ammino butyricacid)) is an amino acid and a neurotransmitter that is effective in controlling seizures or depression and lowering blood pressure (the effect of controlling blood pressure is complications caused by diabetes, improvement of liver and kidney function, prevention of obesity, It improves menopausal disorders, systemic asthenia, headache, etc.), promotes brain cell metabolism (improves learning ability), increases memory, relieves stress, relieves premenstrual tension in women, and strengthens immunity.

In addition, it has been reported that a decrease in the GABA content in the brain is highly likely to cause alcoholic brain disease.

In order to relieve a hangover, bean sprouts, bukeo, and mung beans have been used as food for relieving hangovers after drinking. In particular, bean sprouts are rich in aspartic acid, which is known to protect the liver by promoting alcohol decomposition by helping the action of acetaldehyde (ADH), and hangover-relieving drinks containing aspartic acid are also on the market. Most of them are used without scientific verification of, and only recently, there is a scientific approach to the alcohol decomposition efficacy of some substances.

In addition, many studies have been conducted to find drugs that can reduce hangovers, and although many drugs have already been introduced, not many have remarkably excellent effects. Even if they are effective, synthetic chemicals show toxicity and side effects, making it difficult to use as a health food. Not suitable Therefore, there is an urgent need for research to find substances that help relieve hangovers from natural substances and to prove their effectiveness scientifically.

In other words, in relation to the removal of hangovers before and after drinking, various health supplements containing ingredients extracted from natural foods or herbal medicinal materials are being developed for the purpose of relieving hangovers and protecting the stomach, but among the various hangover symptoms caused by drinking, only some symptoms are effective. Or the hangover relief effect was insignificant.

Conventional health supplements using natural products related to hangovers have a hangover relief effect, but reduce the digestive function of nutrients in the stomach or small intestine due to alcohol consumption and the effect of alcohol breakdown metabolism, and take due to the unique aroma and taste of herbal medicines. It is difficult to do, and if left for a long time, there is a problem such as that it is not good visually due to the formation of sediment. Therefore, when ingested, the organoleptic and basic digestive function in the stomach or small intestine is improved while reducing the inherent aroma and taste of the herbal medicine to relieve hangover. Development of new hangover relief products that can be effective is in progress.

However, despite various efforts to relieve hangovers after drinking as described above, the development of foods that can effectively alleviate or relieve hangovers is still insignificant compared to the demand, so there are no side effects and the effects are sufficiently recognized. Food development is required.

In recent years, in addition to products in the form of simple hangover-relieving beverages that contain hangover-relieving functional ingredients such as aspartic acid, development of hangover-relieving functional foods with complex functions such as hangover as well as fatigue recovery and gastrointestinal protection is becoming more diverse.

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Fermented food is a generic term for food produced through a fermentation process, and a number of functional fermented foods including functional substances that are beneficial to the human body produced as a result of fermentation have been introduced. In particular, functional fermented foods containing a large amount of total polyphenols and flavonoids were introduced in relation to the enhancement of liver function.These functional fermented foods have excellent antioxidant activity and physiological activity, DPPH radical scavenging ability, and ABTS radical scavenging ability. Showed activity.

In addition, fermented foods are economical foods that ensure preservation and hygiene safety due to excellent food storage. By fermenting the foods, high molecular weight substances are decomposed into low-molecular substances to increase digestion and absorption. Since a component having is produced, in recent years, research on useful substances having a tertiary function effect and research on fermentation metabolism in fermented foods have been actively conducted.

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As there is no place to throw away the whole tree, the Hwangchil tree has high economic value, greening of natural environment recovery, and an excellent plant of one stone and two groups, and it is known for some pharmacological effects in addition to the action as a paint.

The composition of Hwangchil consists of 66.7% of nonvolatile components, 10.8% of fragrance components, 8.1% of moisture, and 14.4% of solids, which are paint components that form a golden color coating. Aroma components are mainly composed of sesquiterpenes β-cubebene, γ-selinene, and δ-cadinene, and these components show sedative and tonic effects on the nervous system. This antioxidant effect, anti-hypertensive effect, anti-cancer effect, hepatocyte protective effect, etc. are known to be effective in preventing, treating, and improving diseases of increasing severity in modern society. When certain ingredients are separated from Hwangchil due to its pharmacological action Not only can it be used as a medicine, but unlike lacquer, it rarely causes skin allergies and is easy to handle, so it can be seen that it can be widely used as a health food by appropriately secondary processing hwangchil.

Therefore, the aforementioned Hwangchil extracts various effective ingredients through analysis of the resin composition of Hwangchil trees, and recently, as various health promotion and treatment effects have been known, its use has gradually expanded and various functional drinks, drugs, etc. New applications are being pioneered.

The Hwangchil tree is one of the three medicinal plants using the scientific name Panax, along with Panax ginseng and Acthopanax, which are the same Araliaceae plants. In addition to the homeostatic function that maintains normal body functions, the liver caused by alcohol As research papers proving various functions such as damage suppression, blood cholesterol improvement, immunity enhancement, and skin whitening effect have been recently published one after another, the value of Hwangchil Tree is soaring.

In particular, Hwangchil improves liver function, relieves hangover, recovers from fatigue, has various detoxification effects, and is found to be effective when hepatic cells are not motivated, so it is substituted or used in combination with existing treatments for the purpose of preventing and treating diseases related to hepatocyte protection. So you can use it with confidence

Hwangchil tree is excellent in improving liver function, so when Hwangchil extract is administered, it has excellent liver protection effect by alcohol and is very excellent for hangovers. In particular, even though it has hepatocellular protective effect, it does not have any special side effects, so it can be used for the purpose of preventing and treating diseases related to hepatocellular protection such as fatty liver, hepatitis, cirrhosis, etc.It is also good for cancer patients with its strong anticancer effect and has the effect of regenerating bones and teeth.

However, clove components such as sesquiterpene contained in Hwangchil have various pharmacological effects as well as value as a benzoin that makes the mind and body clear and comfortable, so studies have been actively conducted to maximize the efficacy of Hwangchil. Hwangchil also has a function as a medicinal material, but it is not easy to consume by itself, it is difficult to process raw materials, and its pharmacological activity per unit weight is not strong, so the development of functional foods that are enhanced than the pharmacological effect originally possessed by herbal medicines is required.

Recently, as various physiological effects of seaweeds among natural products have been revealed, studies on physiologically active substances isolated from seaweeds are actively progressing, and a movement to develop and use the functions as high value added is becoming active. As constituents of seaweed, polysaccharides and glycoproteins, as well as proteins, vitamins, and minerals, have been reported to have antiviral, anticancer, and immune activities.

In particular, as seaweeds have recently proven various physiochemical effects, interest in physiologically active substances derived from seaweeds is increasing.Because they are rich in dietary fiber, research for the prevention and treatment of hypercholesterolemia is actively underway. Seaweed, one of the representative low-calorie foods, has been reported to have preventive effects on arteriosclerosis, myocardial infarction, high blood pressure, and stroke, which are the causes of adult diseases, and suppress aging of alginic acid, a representative bioactive substance of brown algae, inhibit the absorption of heavy metals in the intestine, and anticancer effects. have.

Seaweeds are divided into red algae, green algae, and brown algae depending on their color, that is, photosynthetic pigment. Brown algae include seaweed, seaweed, tot, hatchet, Ecklonia cava, moxibustion, and thread. Red algae refers to seaweed, agar, and kosiraegi. Green algae are known to have the effect of lowering cholesterol content in blood as glucuronoxylorhamnan as the main active substance in green algae, especially green algae, green algae and green algae.

As a special product of Namdo, which grows only in clean and clean sea areas such as Gangjin and Wando, Jeollanam-do, it is rich in dietary fiber and taurine, which is effective in soothe the soreness after drinking. It is a hangover reliever of wild seaweed, belonging to the genus Capsosiphon fulvescens. Nutritionally, as an annual seaweed that is a food of low calorie, low fat, high protein, high calcium, high iron, high dietary fiber, and high chlorophyll, it is widely distributed around the world.In Korea, the south coast or the west sea where chronic conditions such as Jangheung and Wando are dominant. It lives on the southern coast. The crude protein content, particularly the essential amino acid content, is higher than that of other seaweeds, and contains a large amount of minerals such as Fe and Se, and vitamins A, C and ω-3 fatty acids, so it is excellent nutritionally.

Maesengi, which is called the'noble of seaweed' and is also a representative seaweed menu, has a strong sweetness and a deep scent, and is in season between December and February every year, depending on the time of harvesting, although there are differences in general ingredients and mineral content, but about 50% sugar. In addition to its excellent palatability as a food, it contains 35% protein and has high utilization value of physiological functional substances such as hangover relief effect and anti-cholesterol. Aspartic acid, which is good for hangover relief, is 3 times more than bean sprouts, and vitamins, minerals, carbohydrates, proteins, fats It is good for growth and development and prevention of constipation as it is evenly equipped with 5 major nutrients such as.

In particular, Maesaegae is a cultured variety that grows only in clean waters because it is sensitive to environmental pollution, and although it is a resource that can increase added value as an eco-friendly food material and health functional food ingredient, it is not possible to collect natural Maesamyeoni except in winter. New processing methods are required to satisfy consumers' needs as it is necessary to increase the availability through the development of safe foods and acquisition of functional substances that can exert the original effects of natural, natural medium.

In other words, Maesengi is a food that is produced only from December to February every year, and has a unique scent and taste, and has been used for food since long ago. In addition, it is rich in minerals and vitamins, is not only good for growth and development of children, but is known as a seaweed that lowers cholesterol and effectively prevents high blood pressure.It is very sensitive to environmental pollution, so when pollutants are introduced from the land, the growth decreases and the organic acid content is low. There is a problem that even a little bit melts, resulting in lower production.

In addition, because of the ecological characteristics that grow in the intertidal zone of coastal waters where the depth of the water is shallow, the algae can be contaminated with various organic and inorganic foreign substances derived from the soil of the mud pearl. Therefore, it is difficult to expect the expression of intrinsic flavor characteristics, and the preservability in the fresh state is also poor.

The literature that introduces the prior art is as follows.Since this prior art does not have the effect as expected, it combines the effects of relieving and preventing hangovers, recovering from fatigue after drinking, recovering intestinal health, and improving memory. It has a common problem that does not meet the requirements for comprehensive use as a functional composition for relieving and preventing hangovers, which must satisfy various needs of consumers at once.

Document 1: Korean Patent Application Publication No. 10-2007-0101443

(A composition for relieving hangovers containing mixed herbal extracts as an active ingredient, published on October 17, 2007)

Document 2: Korean Patent Application Publication No. 10-2004-0097112

(Hwangchil extract with hepatocyte protective effect, health supplement containing hwangchil fraction as an active ingredient, November 17, 2004)

Document 3: Korean Registered Patent Publication No. 10-0834870

(Method of manufacturing Maesengi extract and health food using the same, May 28, 2008)

Accordingly, the present inventors studied to develop a new composition for relieving hangovers that has no side effects on the human body and has excellent efficacy in resolving hangovers caused by alcohol. It is an ideal combination of natural botanical ingredients that help to recover from fatigue and smooth blood circulation by including extracts. Hwangchil tree extract or Maesamensis extract extracted by mixing to have an enhanced effect than the original pharmacological effect It is an effect of complexly increasing functions by mixing and forming in an appropriate concentration so that they can complement each other without loss of physical properties or loss of active ingredients.It has excellent hangover relief and prevention effects without side effects on the human body, as well as fatigue recovery and bowel movement after drinking. The present invention has been completed to implement a complex health recovery effect.

As described above, when used as described above, Hwangchil tree extract, Maesengyi extract, and herbal extracts of the prior art, which have respective functional characteristics, have the effect of relieving and preventing hangovers caused by excessive drinking alone, recovering from fatigue and recovering intestinal health after drinking. And it has a problem in realizing the effect of solving all complex symptoms such as the effect of improving memory.

Each functional active ingredient has an augmented effect compared to the original pharmacological effect, so that the Hwangchil tree extract and Maesengi extract, which are mutually compatible with each other, are in an appropriate concentration so that they can complement each other without loss of physical properties or loss of active ingredients. By mixing and creating a mixture, it is possible to satisfy a variety of needs of consumers at once with the effect of increasing the function in a complex manner.Therefore, it is not only effective for relieving hangovers when ingested before and after drinking, but also for relieving fatigue and intestinal health after drinking. As an additive that interacts with the Hwangchil tree fermented extract, the technical problem of developing a hangover-relieving complex extract containing a mixture of Maesengi extract was solved in the present invention.

The present invention has been devised to solve the problems of the prior art described above,

Breaking away from the hangover relief composition of the prior art, where the efficacy effect is fragmentary or limited, and only partial effects could be expected for various symptoms of hangover disease,

Hwangchil tree which enhances the pharmacological activity of Hwangchil tree by fermenting the leaves and branches of Hwangchil tree, which have various physiological activities such as hangover relief, fatigue recovery, liver cell protection, antidiabetic, antioxidant, and immunity enhancement, to minimize loss of functional ingredients. Fermented extract contains a large amount of various inorganic salts such as iron, potassium, iodine and vitamins A and C, so it has a hangover relief, gastric ulcer or duodenal ulcer prevention and sedation, cholesterol lowering, children's growth promotion and constipation treatment. By mixing and forming the extracts, which have efficacy, so that they can complement each other without loss of physical properties or loss of active active ingredients, the function is multiplied and enhanced than the original pharmacological effect can be realized. Hwangchil tree fermented extract as a health functional composition for hangover relief with improved alcohol decomposition activity of a new composition, which has not been used in combination, while having excellent efficacy to effectively prevent hangovers caused by 過飮. It is an object of the present invention to provide a method for preparing a complex fermented extract for relieving a hangover in which a mixture of and meesengyi extract is mixed.

As described above, the hangover-relieving complex fermented extract in which the Hwangchil tree fermented extract and Maesengi extract according to the present invention are mixed is a hangover-relieving agent considering not only hangover but also fatigue and intestinal health recovery after drinking,

Iron, potassium, fermented extract of Hwangchil tree that enhances the pharmacological activity of Hwangchil tree by fermenting Hwangchil tree leaves and branches that have various physiological activities such as hangover relief, fatigue recovery, liver cell protection, antidiabetic, antioxidant, and immunity enhancement. Since it contains a large amount of various inorganic salts such as iodine and vitamins A, C, etc., it is an extract of meesengi, which has the effect of relieving hangovers, preventing and sedating gastric ulcers or duodenal ulcers, lowering cholesterol, promoting children's growth and treating constipation. By mixing and creating a synergistic effect complementary to each other without deterioration of physical properties or loss of active ingredients, the function is complexly increased to realize an augmented effect than the original pharmacological effect, resulting in a hangover caused by excessive drinking (過飮). It realizes excellent efficacy that can effectively prevent 宿醉).

In particular, the present invention eliminates the hangover effect of the Hwangchil tree fermented extract, which maintains normal body functions, in addition to the hangover-relieving effect of the meesengyi extract. The benefits of Hwangchil tree and Messengyi extracts are maximized, and the hangover relief effect is significantly improved compared to the extracts, thereby suppressing or reducing headaches, diarrhea, loss of appetite, nausea, vomiting, chills, and night sweats that appear after drinking alcohol. It recovers the body from decline in exercise capacity, and can maintain the hematologic and hormonal normal state, so it is synergistic and synergistic with the combination of herbal ingredients, so that it does not harm the liver before and after drinking, and when applied to the living body, it has a wide range of hangover relief effects. Will perform.

Eventually, the hangover relief composition of the present invention may exhibit equivalent or better hepatocyte protective effects while containing each active ingredient in a more reduced content due to the synergistic action of each active ingredient contained therein, so a high content of each active ingredient While it can greatly reduce the risk of side effects, it can show excellent liver function improvement effect, so it is very effective in protecting or healing liver damage caused by heavy drinking or chronic alcohol intake, and it promotes alcohol metabolism after drinking alcohol in blood. It has an excellent function of lowering the level and has the effect of enhancing the antioxidant activity in the body, so that when the composition of the present invention is eaten or consumed in a food form, it is possible to lower the blood alcohol level due to excessive drinking or chronic alcohol intake. It improves antioxidant activity in the body and at the same time relieves all symptoms associated with typical hangovers such as headache, heartburn, thirst, and bad breath.

In addition, the present invention maximizes the merits of Hwangchil tree in the fermentation process. Cell membranes of Hwangchil tree branches, leaves, fruits, and roots are destroyed, and the active ingredients contained by microbial crushing are soluble in water, and the dissolved fermentation product is dissolved in the body. It can be easily absorbed, and by promoting alcohol metabolism in the living body, lowering the alcohol concentration and the concentration of acetaldehyde, it is possible to efficiently eliminate hangovers caused by alcohol intake, so it can be widely used in relieving hangover symptoms caused by excessive alcohol intake. I can.

In addition, the composition according to the present invention provides stability of the formulation by having an optimal blending ratio, and is effective in preventing and relieving hangovers, as well as supplying nutrients necessary for the liver, improving blood circulation and improving chronic fatigue.

In particular, the composition for relieving a hangover of the present invention can be used as a hangover relieving agent because it reduces the alcohol concentration and acetaldehyde concentration in the serum at the beginning when alcohol intake, and can be used as a fatty liver prevention agent because it reduces induction to fatty liver when ingesting alcohol for a long time.

In other words, the composition for relieving hangover of the present invention greatly reduces the blood concentration of alcohol by increasing the activity of alcohol dehydrogenase, and at the same time suppresses nerve damage caused by alcohol, thereby promoting the hangover relief effect and activation of brain function. When drinking excessively or regularly drinking, it suppresses the cognitive impairment that is usually caused, and also relieves the phenomenon of black out after drinking.

Therefore, the present invention maintains health by allowing the body condition to be maintained in a normal state before or after the occurrence of a hangover, and by fermentation, the bitter taste and odor of the herbal material are removed to improve medication compliance, and the extraction rate of active ingredients of the medicine It is possible to increase the body and make it easier to absorb in the body.

In addition, the composition according to the present invention is hygienically manufactured with an ideal blend of natural vegetable raw materials that help to smooth fatigue recovery and blood circulation, taking into account the irregular lifestyle of modern people, and granules and powders ( powder), pills, capsules, and tablets, or a method for preparing a hangover-relieving complex extract for lowering cholesterol.

The present invention does not harm the liver and lowers the concentration of acetaldehyde, which is an alcohol metabolite as a substance causing a hangover, and the concentration of residual alcohol remaining in the body, so that the physical symptoms of hangover are headache, fatigue, sensitivity to irritation, diarrhea, decreased appetite, vomiting, It can comprehensively relieve tremors, mental symptoms such as dizziness, work ability and cognitive decline, depression, anxiety, and excitement.

In the end, the composition of the present invention contains a large amount of polyphenols and flavonoids, and is a Hwangchil fermented extract that relieves mental and physical stability and stress by releasing alpha waves, which are brainwave substances, as a benzoin that relieves hangovers and stabilizes nerves through decomposition of acetaldehyde components. It contains glycogen (glycogen, a polymer of glucose) that helps metabolism of acetaldehyde, and a mixture of meesengi extract that helps alcohol decomposition, and contains low-molecular ginsenoside and GABA, both functional substances, to relieve hangover and fatigue. It will be beneficial for the purpose of recovery.

The configuration of the present invention for achieving the above object will be described in detail as follows.

All technical terms used in the present invention, unless otherwise defined, are used in the same sense as those of ordinary skill in the art generally understand in the related field of the present invention. In addition, although preferred methods or samples are described in the present specification, those similar or equivalent are included in the scope of the present invention.

The present invention provides various inorganic salts such as iron, potassium, iodine, and vitamins A and C in the fermented extract of Hwangchil tree leaves and branches that have various physiological activities such as hangover relief, fatigue recovery, hepatocyte protection, antioxidant activity, and immunity enhancement. It is useful in which microorganisms are grown as much as possible through fermentation in the fermented extract of Meesamsaeng, which has the effect of relieving hangover, preventing and sedating gastric ulcer or duodenal ulcer, lowering cholesterol, promoting children's growth and treating constipation. The fermented extract of rice bran fermentation with high alcohol-degrading enzyme activity is added to enhance GABA (gamma-ammino butyricacid) by low-temperature fermentation with a microbial culture medium. Hwangchil fermented extract helps to decompose acetaldehyde components with increased fermentation efficiency and Maesengi fermented extract helps to decompose alcohol through high alcohol metabolism promotion by containing a large amount of natural GABA (gamma-ammino butyricacid). High-concentration gaba enhancement effective in relieving hangovers through synergistic effects through interaction. Complex functional food fermented extract is mixed and formulated as an essential component as the main ingredient, but the Gaba-enhanced complex functional food fermented extract has an antimicrobial function as a supplementary ingredient to supplement functionality. And as a natural product that performs bactericidal action, it further reinforces the antioxidant function by selectively adding gardenia extract or turmeric extract containing a large amount of phenol and flavonoids,

In addition to its excellent antioxidant effect, it is effective in removing hangovers because it contains abundant vegetable fiber, taurine, iron and calcium amino acids, and it increases the content of Gaba (gamma-aminobutyric acid) to further increase the yield of GABA and increase the yield of large amounts of natural GABA. In order to realize the effect of relieving hangover after drinking through high alcohol metabolism accelerating action, it activates Gaba receptor and selectively adds Ecklonia cava extract and kelp extract as seaweed rich in polyphenols,

In addition, in order to further reinforce hangover relieving and hepatocyte protective function, herbal extracts consisting of licorice, jujube, cinnamon, ginger, angelica and brown root, which are used as solubilizers of poorly soluble substances as natural hangover relieving herbs, are also added,

A fruit extract consisting of pears and plums, which are rich in aspartic acid and citric acid, which improves liver function, is formed by adding and mixing 5 parts by weight to the fermentation process as an additive to the fermentation process, respectively, relative to 100 parts by weight of the main raw material, thereby improving bioavailability and physiological activity. A variety of healthy ingredients that are effective in improving hangovers and excellent in taste and scent can be easily and conveniently ingested together, allowing the damaged liver to quickly recover before and after drinking through the synergy of each active ingredient. It relates to a method for preparing a hangover-relieving complex fermented extract in which the extract is mixed.

The present invention mainly comprises a mixed raw material comprising a fermented extract of Hwangchil that helps decompose acetaldehyde components in order to relieve a hangover, a fermented extract of Maesengi fermentation that helps decomposition of alcohol, and a fermented rice bran extract extracted from a natural product rich in gamma-ammino butyricacid. Herbal extract consisting of licorice, jujube, cinnamon, ginger, angelica and brown root as a hangover-relieving herbal medicine to further reinforce antioxidant effect, hangover relief, and fatigue recovery effect as a raw material and as an auxiliary material that realizes complex synergistic effect by interaction. As a seaweed that activates gaba receptors, it is a comprehensive function of complex functions such as fatigue recovery and gastrointestinal protection as secondary effects in addition to the main purpose of relieving hangovers by selectively adding Ecklonia cava extract, kelp extract, and fruit extract consisting of pears and plums. Will perform.

In the present invention, the fermented extract of Hwangchil, Maesengi and rice bran is fermented as a natural fermented product that enhances the pharmacological activity of Hwangchil trees by fermenting Hwangchil tree leaves, branches, Maesengyi, and rice bran by a low-temperature extraction method that optimizes active ingredients. Hwangchil tree leaves, stems, and cell membranes such as Messengyi are destroyed, microorganisms are crushed finely, and the active ingredients contained are dissolved in water, and the dissolved fermentation product is formed so that it can be easily absorbed in the body. Because it is low, it is possible to prevent the useful components from being destroyed or deteriorated by heat.

In particular, the present invention is a fermentation strain having excellent gava-producing ability to overcome the limitations of microbial application, and extracts with a complex synergistic effect by fermentation of complex enzymes in which various components such as microbial groups and enzyme groups are organically and complementarily combined. By mixing and composition so that the active ingredients of each of the active ingredients can complementary and synergistically act without deterioration or loss of physical properties, the function is enhanced in a complex manner to realize an enhanced effect than the original pharmacological effect. The wild grass enzyme or complex enzyme is a mixture of glucosidases that break down carbohydrates, proteases that break down proteins, and lipases that break down fat, so that the enzyme becomes mono- or low-molecular. As a result, the time required to activate the microorganisms is shortened as much as possible and the yield of physiologically active ingredients is increased.

The functional complex extract for relieving hangover of the present invention may be extracted only with fermented microorganisms, but it is preferable to add a complex enzyme for promoting microbial activity that contains a combination of wild plant enzyme, carbohydrate degrading enzyme, proteolytic enzyme, and lipolytic enzyme. When fermentation is carried out by adding wild grass enzymes or complex enzymes to the fermenting microorganism, the enzyme can ferment the microorganisms more quickly, and Hwangchil wood, the main raw material of the present invention, is a raw material containing many antibacterial components. Since the reaction may not be carried out well even if performed, it is preferable to add a wild plant enzyme or a complex enzyme to the fermentation microorganism in order to solve this problem.

In addition, the fermentation rate is improved without spoilage by fermenting hwangchil, meesengi, rice bran, medicinal herbs, etc. into ultra-fine powder, and by fermenting medicinal herbs, medicinal herbs, and grains, the digestion and absorption of active ingredients is improved. This ultra-fine powdering process includes a cyclone that pulverizes Hwangchil or Maesengyi with an air-flow type grinder to pulverize and then collects the powder, and is classified with a double-type cyclone classifier that separates the coarse powder from the powder collected by the cyclone. By pulverizing the closed circuit system that repeats the operation 5 times and classifies it into nano-sized ultra-fine powder, it is possible to use the composite raw material powder finely powdered into nano-sized ultra-fine particles of 20 μm or less.

In addition, by far-infrared radiation sterilization drying using far-infrared radiation energy, the heat exposure time is shorter than that of general hot air drying, resulting in less damage to saponin components, resulting in increased antioxidant activity.Recently verified research results show that far-infrared treatment is performed with glutamic acid such as rice (GLUTAMIC ACID). It is known to increase GABA (γ-aminobutyric acid) by activating decarboxylase. That is, when irradiated with far-infrared rays, it is possible to induce maximization of antioxidant power by releasing and activating low-molecular antioxidants present in natural products, and at the same time, heavy metals and harmful substances can be removed through strong sterilization and purification of far-infrared rays.

In addition, in the present invention, the final composite fermented product may employ a freeze-dried pulverization method, which is a cryogenic ultra-fine pulverization technology, and the freeze-dried pulverization of Hwangchil tree leaves and branches with low absorption power in vivo, and the fibre As it is made of ultra-fine powder with cell wall decomposed like cell wall degrading enzyme treatment in quick freeze dryers and crushers, it can prevent loss of nutrients due to heat, and can consume its own nutrients as it is, so chemical components are stabilized compared to general natural drying. It has the effect of reducing the risk of deterioration due to its low moisture content.

In addition, it is preferable that the composition of the present invention radiates far-infrared rays and increases the activity of the active ingredient by aging and fermenting in a fermentation tank such as a pot made of loess material that allows breathing by forming micropores.

In addition, in the present invention, the purified water is preferably nano-bubbled water that promotes high-purity sterilization and disinfection of microorganisms and decomposition of hardly decomposable organic matter.

That is, the purified water of the present invention as described above is water containing fine oxygen bubbles that are invisible to the naked eye as nanopore-sized bubbles, so nano bubbles can exist in the liquid for a long period of time, thus performing complex actions such as sterilization and deodorization as well as water purification. With its strong sterilization power, it additionally performs a sterilization action that promotes the high-purity sterilization and disinfection of microorganisms and the decomposition of non-degradable organic matter.

Eventually, the fermentation composition prepared by the manufacturing method of the present invention is converted into saponin form that can be absorbed in the body through complex enzyme fermentation such as Bacillus bacillus and lactic acid bacteria, such as saponin of Hwangchil. Since active substances and fibers are decomposed, absorption in the human body is improved, off-flavors are reduced, and various enzymes contained in the enzyme fermentation solution can be ingested as they are, so digestive enzyme activity and antioxidant activity are excellent.

In addition, in the present invention, in order to further increase the yield of GABA, as a natural product containing glutamate, licorice and kelp extracts are further reinforced in addition to Maesengyi to effectively reduce the molecular weight to a state that can be absorbed by humans through fermentation. It is effective in relieving hangover after drinking through high alcohol metabolism promoting action.

Therefore, the complex fermented extract for relieving hangover and improving liver function according to the present invention has an increased alcohol fermentation efficiency by the fermentation process, and contains natural GABA derived from rice bran and seaweed as an active ingredient using a fermented strain having excellent GABA production ability. In order to realize the physiological function of GABA, it overcomes the limitations of conventional GABA raw materials, which require a large amount of intake, and shows an effect on relieving hangovers after drinking through high alcohol metabolism promoting action by containing a large amount of natural GABA.

Gamma-Amino Butyric Acid, called GABA, is known to be involved in regulating physiological functions such as promoting brain function, improving concentration, stabilizing mind, and lowering blood pressure. GABA's general efficacy is an amino acid and a neurotransmitter that is effective in controlling seizures or depression. In addition, it is effective in removing hangover by promoting alcohol metabolism, and lowering blood pressure (this blood pressure control effect improves complications due to diabetes, improvement of liver and kidney function, prevention of obesity, menopausal disorders, general weakness, headache, etc.), brain It is known for functions such as promoting cellular metabolism (improving learning ability), increasing memory, relieving stress, relieving women's premenstrual tension, strengthening immunity, and restoring vision.

As the main component of the present invention, Hwangchil trees are reported to be effective in many diseases such as improving blood circulation (cholesterol, blood pressure), antioxidant (anti-aging), improving liver function (hangover, fatigue, detoxification), immunity enhancement, and regeneration. The scientific research of Hwangchil Tree has been recognized for its nutritional, pharmaceutical, and therapeutic value.

The fermented extract of Hwangchil wood of the present invention is a safe natural substance using Hwangchil wood, and has no side effects on human application and shows excellent effects in relieving hangovers.

In particular, as a hangover-relieving component contained in the present invention, flavonoids act as antioxidants that rapidly decompose acetaldehyde, a substance that causes hangovers, and prevent the generation of harmful oxides, Free Radical, in the blood. It has an anti-inflammatory effect, antibacterial effect, immunity activation, oral odor removal effect, blood vessel strengthening to expand and strengthen capillaries, lowers GPT level and protects damaged liver. It has an excellent effect in preventing damage to and diluting the toxicity of alcohol metabolism intermediates, and the flavonoids are the main components of Maesengyi, which improves the antioxidant effect of taurine, which improves liver function by reducing fatigue and lowering cholesterol.

As is well known, taurine is an amino acid containing sulfur and is distributed in various parts of our body such as liver, brain, heart, and muscles, and is widely known as an antioxidant that prevents oxidative damage along with cysteine.

In particular, in the present invention, the heat exposure time is shorter than that of general hot air drying through far-infrared sterilization drying using far-infrared radiation energy that emits a wavelength in the range of 2 to 14 μm while promoting saponin components beneficial to liver function recovery by fermenting hwangchil by complex enzymes. The saponin component is less damaged and the antioxidant activity is increased.

The saponin component increases the amount of hormones that break down alcohol and activates liver function, so it has the effect of reducing blood alcohol concentration.

In particular, the present invention fermentes hwangchil using one or more useful microorganisms to increase the absorption rate of saponin, an active ingredient of hwangchil, and induces conversion of the glycoside structure of saponins using microorganisms' glycolytic enzymes or complex enzymes. Thus, the nutritional and functional value is increased.

In the present invention, the Hwangchil tree can be used without limitation, such as resin, leaves, roots, and fruits of the tree, but in the present invention, the Hwangchil tree is used by mixing leaves and branches. For this purpose, it is preferable to mix and use the mixing ratio of hwangchil tree leaves and branches in a weight ratio of 7:3.

In addition, the leaves of the hwangchil tree can effectively improve leaching properties through a stir-fry treatment to increase flavor.

In addition, in general, seaweed is rich in vegetable fiber, taurine, which improves liver function by lowering fatigue and cholesterol, and amino acids such as iron and calcium, which are effective in removing hangovers, and damaged liver and liver can be quickly recovered after drinking, which is the oxidative effect of the brain. It functions as a natural hangover reliever that suppresses damage.

Among seaweeds, Capsosiphon fulvescens, belonging to the genus Galparaeaceae, is an annual algae and is widely distributed worldwide.In Korea, it lives in the southern coast of the south coast or the southern west sea where chronic conditions such as Jangheung and Wando in Jeollanam-do are dominant. The amino acid content is higher than other seaweeds, and it contains a large amount of minerals such as Fe and Se, vitamins A, C and ω-3 fatty acids, so it is excellent in nutrition and has been used as a local food for a long time. Maesengi-guk, boiled with oysters, is a representative food of Namdo, and has a unique flavor and sweetness, and is used as a high-quality haejang food.

In particular, it contains a high content of aspartic acid, which is effective in relieving hangovers, relieving fatigue, and detoxifying the liver.Meisengyi, which is rich in various minerals and vitamins, provides nutrients to the liver as well as soothes stomach ulcers, so it has excellent hangover effects after drinking alcohol.

Rice bran is a by-product that occurs during the milling process of rice. It contains ingredients such as polyphenols that are effective for the human body, so it is a food with high nutritional value. Recently, ingredients such as polyphenols, hemicellulose and pectin have immune function. Studies have been published showing that when rice bran is fermented, the total polyphenol content is remarkably increased, and antioxidant effects such as superoxide dismutase (SOD) activity become active.

The composition of rice bran varies depending on the variety of rice and method of grinding, but rice bran was analyzed to contain 105% moisture, 4826% carbohydrates, 1743% crude fat, 151% crude protein, and 88% crude ash. It was found to be unsaturated fatty acids such as oleic acid and linoleic acid (Choi et al, 2010). In addition, it contains various nutrients such as vitamin A, B, B6, iron and phosphorus. Therefore, it was found that rice bran is a by-product of polished rice, but it is an excellent material in terms of nutrition.

Rice bran is an important component capable of promoting the growth of microorganisms and promoting fermentation. A large amount of GABA (gamma-ammino butyric acid) contained in it is extracted to further increase the amount of GABA in the fermentation product. In the present invention, microbial cell growth After preparing a culture solution containing a sugar nutrient for promoting the growth of microorganisms that can be used as a carbon source necessary for the plant, the useful microorganisms for fermentation of sugar sources are expanded and cultured in two steps using the sugar nutrient culture solution prepared as described above, and the sugar nutrient culture solution By supplying a variety of complex microorganisms to promote and activate the proliferation of complex microorganisms, to increase the activity and survival rate, and to produce a complex microbial active culture solution that exhibits a strong power by combining different species, and then add grain to the complex microorganism culture solution. A high-concentration Gaba-enhanced fermentation extract that maximizes the absorption efficiency of nutrients such as Gaba is prepared according to a fermentation manufacturing process in which the above complex microbial active culture solution is fermented by mixing rice bran rich in GABA as a processing by-product.

In particular, the Gaba-enhanced fermentation extract in the present invention is a culture solution containing a sugar nutrient separately prepared to promote microbial growth in the present invention, and cultured in two sequential steps for proliferation according to the adaptation and immunity of the microorganism. By adding and fermenting the expanded-grown complex microbial active culture broth to the rice bran, it is enhanced by fermentation of rice bran itself and lactic acid bacteria, and is rich in GABA (gamma-ammino butyricacid) content, which maximizes the absorption efficiency of nutrients. It contains lactic acid bacteria and Bacillus bacteria, which have strong viability even during distribution, so that it helps the intestinal function of the user who ingested the composition of the present invention.

In the present invention, the separately prepared culture solution for promoting microbial growth containing sugar nutrients is 30 parts by weight of sugar, 30 parts by weight of glucose, 20 parts by weight of potassium chloride, sodium hydrogen carbonate based on 100 parts by weight of purified water heated to 50 to 60°C. 5 parts by weight, 5 parts by weight of acetyl salicylic acid, and 10 parts by weight of citric acid may be included in the mixture by stirring and heating.

In particular, the high-concentration Gaba-enhanced rice bran ferment extract according to the present invention contains carbohydrates, proteins, and lipids, which are active ingredients of rice, so it is rich in antioxidants and is not toxic, and alcohol dehydrogenation is an important factor in alcohol detoxification. It increases the activity of enzyme (ADH) and aldehyde dehydrogenase (ALDH), and lowers the concentration of alcohol in the blood and acetaldehyde in the liver, which is known to be the main cause of hangovers, so not only relieves hangovers, but also occurs due to stomach acid secreted excessively by alcohol. It can also help relieve heartburn.

In addition, the Hwangchil tree, Maesengyi, and rice bran fermentation extract are added to the main ingredients to help strengthen immunity and recover from fatigue, and as an auxiliary ingredient that enhances antibacterial function. As a carotenoid-based antioxidant, it is a yellow-based natural pigment and has antibacterial and bactericidal action against bacteria. As a natural product that performs phenol and flavonoids, it has an anticancer effect, and by selectively adding gardenia extract or turmeric extract, which has a high content of dietary fiber, which helps in activating bowel movements, the antioxidant function is further reinforced.

Donguibogam, which acts as a natural preservative, is recorded in Donguibogam, "The property is cold and taste bitter, has no poison, is effective in gastritis, controls upper heat of the small intestine and heart, makes urine well, removes jaundice." It is known that crocin and crocetin in Eda gardenia promote bile secretion by promoting secretion and excretion of bile and inhibiting the increase of bilirubin in the blood.

In addition, among the fermented seaweed extracts used as auxiliary ingredients, the Ecklonia cava extract and kelp extract are added as brown algae from the seaweed family known to have a strong antioxidant effect, and phlorotannin, a polyphenolic substance that is abundant in Ecklonia, is used as an antioxidant and anti-oxidant. It is known to stabilize the central nervous system by activating gaba receptors with excellent hypertension, anti-thrombogenic and anti-cancer activity.

The kelp, which contains a large amount of gamma-ammino butyricacid, is used to lower cholesterol and blood pressure, lower blood sugar levels to control diabetes, prevent thyroid disease, help bowel movements, eliminate constipation, and release carcinogens to prevent colon cancer. It is used to prevent, relieve hangover, and prevent liver disease.Alginic acid and minerals contained in kelp are effective in removing constipation and stool by activating peristalsis of the intestine, and acidic polysaccharide among kelp ingredients inhibits the absorption of cholesterol. It is known to prevent arteriosclerosis.

In addition, licorice is used as a solubilizing agent for poorly soluble substances as a natural hangover relieving herb that is added to further reinforce hangover and liver cell protection. Licorice is used as a solubilizing agent for poorly soluble substances, but it makes the medicinal effect well appear and prevents peptic ulcer. In addition to cinnamon, which acts on the cell membrane of liver cells to protect the liver, and Galgeun, which realizes a haejang effect by quenching thirst, herbal extracts such as jujube and ginger are added.

In addition, plum is rich in aspartic acid and citric acid, which improves liver function, removes fermentation odor, improves the taste and aroma of the fermented composition of the present invention with fresh flavor and refreshing sweetness, improves sensory properties, and improves consumer preference. Plum tree fruit originated in China, used as food and medicine in the classical Chinese herbal medicine, contains a large amount of minerals, and relieves headaches and keeps the blood weakly alkaline. It facilitates recovery, anti-aging, sterilization, etc., and contains citric acid, malic acid, succinic acid, etc. as organic acids, among which citric acid is abundant, so it decomposes lactic acid, a fatigue substance accumulated in the body, and discharges it from the human body. do.

The pear has a strong sweet taste, and contains digestive enzymes with 90% moisture. It has antipyretic effect. In the recovery period of fever, when you have a sore throat due to cold or tonsillitis, cough or phlegm, drink heat or quench thirst due to hangover. And, it performs the function of fatigue recovery by aspartic acid.

Therefore, in the present invention, each 5 parts by weight of each 5 parts by weight of a harmonious drug enhancing extract compared to 100 parts by weight of the main raw material is further added to the fermentation process as an auxiliary material and mixed so that the components can be easily shared, thereby complementing each other without deteriorating physical properties. It is a composition that additionally includes as an active ingredient so that it can synergize with various organic acids, sugars, vitamins, minerals, amino acids, unsaturated fatty acids, and dietary fiber to improve bioavailability and physiological activity. A variety of health ingredients can be easily and conveniently consumed together, so that the damaged liver can quickly recover before and after drinking due to the replenishment of vitamins C and B destroyed by alcohol through the synergistic action of each active ingredient, and the promotion of metabolism by various nutrients. Thus, it is possible to prepare a hangover-relieving complex fermented extract containing a mixture of fermented extract of Hwangchil tree and fermented extract of Maesengi, which is beneficial to health.

In addition, the hangover-relieving complex fermentation extract of the present invention is prepared by kneading the mixed raw materials and then mixing the formulation with a certain weight of the effective active ingredients such as granules and tablets and oval capsules. It is molded into a variety of formulations contained as it is.

In addition, when preparing the extract of the present invention, the extract itself or the pulverized product, and the extract or fraction thereof, and the composition ratio of each raw material can be added or subtracted within the usual range, and the same or similar compatibility with medicinal materials in addition to the composition It may contain one or more kinds of active ingredients that exhibit a function.

Example 1. Preparation of a hangover-relieving complex fermented food extract in which Hwangchil tree fermented extract and Maesengi fermented extract are mixed

1-1. Preparation of fermented extract of Hwangchil

Hwangchil tree leaves and branches are selected in a ratio of 1:3 by weight, finely chopped, washed with functional water containing nano-bubbles that have sterilization, antibacterial, insect repellent, and cleaning effects to remove impurities and germs, and then dry with hot air. In contrast, the saponin component is enhanced by fermenting the leaves and branches of Hwangchil tree with the effect of far-infrared treatment while minimizing damage to the saponin component through a fast drying process using far-infrared radiation energy that increases antioxidant activity by emitting a wavelength in the range of 2 to 14㎛. Cut the leaves and branches of Hwangchil tree from which moisture has been removed by drying at a temperature of 40-50℃ in a far-infrared sterilization drying device with a sterilization and drying function at a moisture content of 8-10% for 2 hours, and then minimizing the destruction of nutrients below -20℃. It includes a cyclone that collects the powder by pulverizing it by pulverizing it in an air-flow type grinder so that there is no frictional heat or destruction of nutrients, and then collecting the powder, and separating the coarse powder from the powder collected by the cyclone. Hwangchil tree made into ultra-fine powder with cell walls destroyed in the state of nano-sized ultra-fine particles of 20 μm or less by pulverization of a closed circuit system that classifies with a cyclone classifier but repeats the crushing operation 5 times to classify it into nano-sized ultra-fine powder As a fermentation microorganism in the powdery hwangchil mixed raw material of leaves and stems, 5 parts by weight of the powdery hwangchil mixed raw material has improved liver function and protein-degrading Bacillus subtilis, a complex fermentation microorganism composed of a lactic acid bacteria strain and yeast, and the above Complex fermentation 5 parts by weight of wild grass enzyme or carbohydrate degrading enzyme, proteolytic enzyme, lipolysis that promotes microbial activity with a complex synergistic effect in which constituents are organically and complementarily combined by interacting with microorganisms to overcome the limitations of application of microorganisms The complex enzymes for promoting microbial activity containing complex enzymes are each mixed in a fermentation tank made of bio-ceramic material that increases the activity of active ingredients during fermentation by emitting far-infrared rays and forming micropores to breathe. It is fermented at low temperature for 48 hours to prevent destruction of the active ingredient in the enzyme fermenter under the temperature condition of 20℃ to 40℃ to enhance the antioxidant effect, thereby enhancing the pharmacological activity of Hwangchil trees and enhancing the extraction efficiency of total polyphenols, which are active ingredients. A fine powder form of fermented extract of Hwangchil tree obtained by fermentation of Bakbyeok enzyme was obtained.

1-2. Preparation of fermented extract of Maesengi

After selecting and immersing them in purified water for at least 30 minutes, washing them three times with flowing functional water containing nanobubbles that have sterilization, antibacterial, insect repellent, and cleaning effects to remove impurities and germs while discharging salt. It is a fast drying process using far-infrared radiation energy that increases antioxidant activity by emitting a wavelength in the range of ㎛. It is dried in a far-infrared sterilization drying device at a temperature of 40-50℃ at a moisture content of 8-10% for 2 hours and moisture is removed. Freeze-drying in a freeze-drying method to minimize the destruction of nutrients below -20℃, and pulverize in an airflow type grinder so that there is no frictional heat or destruction of nutrients, and then pulverize into fine powder, including a cyclone that collects the powder. It is classified with a double-type cyclone classifier that separates coarse powder from the collected powder, but it is divided into nano-sized ultra-fine particles by repeating the pulverization operation 5 times. The powdered meesengyi in the form of a fine powder without a viscous texture is mixed with 5 parts by weight of Bacillus subtilis compared to 100 parts by weight of the raw material, lactic acid bacteria strains and yeast, and a natural glutamic acid derived from Meesam saengyi. ) To GABA (gamma-ammino butyricacid) by interacting with the complex fermentation microorganisms to promote microbial activity, 5 parts by weight of wild grass enzyme or carbohydrate degrading enzyme, proteolytic enzyme, lipolytic enzyme complexly included Each of the complex enzymes for acceleration are mixed in a fermentation tank made of bio-ceramic material and fermented at low temperature for 48 hours so that the active ingredients are not destroyed in the enzyme fermentation tank at a temperature of 20℃ to 40℃. A fermented extract was obtained.

1-3. Preparation of Gaba-enhanced rice bran fermented extract

A. Preparation of useful microorganism active culture solution

30 parts by weight of sugar, 30 parts by weight of glucose, 20 parts by weight of potassium chloride, 5 parts by weight of sodium hydrogen carbonate, 5 parts by weight of acetyl salicylic acid, 10 parts by weight of citric acid based on 100 parts by weight of purified water heated to 50 to 60°C And heated with stirring to obtain a culture solution containing sugar nutrients for promoting the growth of microorganisms

B. Preparation of fermented rice bran extract

The culture broth extracted in the above step (a) is added to a complex useful microorganism composed of lactic acid bacteria, yeast, and Bacillus bacteria as a rice bran fermentation strain with excellent GABA production ability, and a temperature of 20 to 40°C in a fermentation tank made of bio-ceramic material. Gaba-enhanced rice bran fermentation extract with high alcohol-degrading enzyme activity through low-temperature fermentation through the action of complex fermentation microorganisms by maximizing the growth of microorganisms by sequentially expanding growth and cultivation in two stages for 30-50 hours under conditions Formed.

1-4. Preparation of complex fermented extract of Hwangchil fermented extract, Maesengi fermented extract, and Gaba enhanced rice bran fermented extract

The hwangchil fermented extract obtained in the 1-2. process, 1-2. process, and 1-3. process, and the fermented Gaba-enhanced rice bran fermented extract were complementarily increased in an equal ratio (weight ratio) of 1:1. It is a mixed fermentation composition in which the fermented extract of Hwangchil tree leaves and branches of Hwangchil tree for relieving hangovers and fermented rice extract and fermented rice bran are mixed as active ingredients. A hangover relief complex fermented extract was obtained.

1-5. Preparation of complex fermented extract for relieving complex functional hangover

It is a yellow-based natural pigment as a carotenoid-based antioxidant as a function enhancing ingredient for supplementing functionality to the fermented extract of the complex functional food extracted in the step 1-4. As a natural product that performs antibacterial and bactericidal action against bacteria, phenol and Addition of 5% by weight of gardenia extract and turmeric extract, which have a high content of dietary fiber, which contains flavonoids, has anticancer effect, and helps in activating bowel movement, are added to the fermented extract of the complex functional food to increase quercetin content to further reinforce the antioxidant function,

In addition to its excellent antioxidant effect, it is effective in removing hangovers because it contains abundant vegetable fiber, taurine, iron and calcium amino acids, and it increases the content of Gaba (gamma-aminobutyric acid) to further increase the yield of GABA and increase the yield of large amounts of natural GABA. In order to realize the effect of relieving hangover after drinking through high alcohol metabolism accelerating effect according to its content, it activates the gaba receptor and adds 5 parts by weight of Ecklonia cava extract and kelp extract as seaweed rich in polyphenol components,

Herbal extracts consisting of licorice, jujube, cinnamon, ginger, angelica and brown root, which are used as a solubilizing agent for poorly soluble substances as a natural hangover-relieving herbal medicine to reinforce hangover relieving and liver cell protection function, are also included in the complex functional food fermented extract 5 parts by weight. Add more,

Lactobacillus is formed by adding and mixing 5 parts by weight of fruit extracts consisting of pears and plums, which are rich in aspartic acid and citric acid, to improve liver function as a main ingredient, and 5 parts by weight of each as an auxiliary ingredient compared to the fermented extract of the complex functional food. By containing organic acids and gaba produced by useful microorganisms, such as the benefits of fermentation, as well as a large amount of physiologically active substance called gaba (gamma-ammino butyricacid), bioavailability and physiological activity are improved, and it is effective in relieving hangovers and has excellent taste and aroma. A variety of healthy ingredients can be easily and conveniently ingested together, allowing the damaged liver and liver to quickly recover before and after drinking through the synergistic action of each active ingredient. A complex fermented extract was prepared.

2. Preparation Example: Preparation of a hangover pill

As described above, kneading with the hangover-relieving complex fermentation extract prepared in step 1, and then converting it into 5 mm-sized grains with a pulverizer in the form of a conventional method, removes unpleasant odor and is effective for the elderly with weak digestion. To obtain a functional pill containing the complex fermentation extract for relieving hangover of the present invention.

(Experimental Example 1) Evaluation of influence on alcohol concentration in the body

In order to find out the hangover-relieving efficacy of the present invention prepared through the above examples, a clinical experiment on alcohol concentration in the body was conducted.

In order to reduce the significant difference, the test subjects were 10 healthy men of the same age, 40 years old, and men with similar alcohol consumption were asked to consume the same amount of alcohol (1 bottle of soju, 360ml, 19.5% Alc).

division Control Experimental group Alcohol
Alcohol concentration immediately after (mg/L) 30 minutes of alcohol
After alcohol concentration (mg/L) Alcohol
Alcohol concentration immediately after (mg/L) 30 minutes of alcohol
After alcohol concentration (mg/L) One 0.07 0.11 0.08 0.05 2 0.08 0.16 0.07 0.05 3 0.25 0.33 0.20 0.10 4 0.45 0.60 0.40 0.25 5 0.07 0.12 0.08 0.05 6 0.07 0.15 0.08 0.06 7 0.35 0.45 0.50 0.20 8 0.30 0.40 0.40 0.30 9 0.08 0.20 0.10 0.05 10 0.06 0.15 0.10 0.06

Control group: The group who only drank alcohol but did not consume anything and measured the alcohol concentration (mg/L) with a breathalyzer 30 minutes later, and did not take any recovery agents.

Experimental group: Two weeks after the control experiment as the same subjects, after drinking, taking the complex extract for relieving hangover and improving liver function of the present invention, and measuring alcohol concentration with a breathalyzer,

delete

As shown in the above table, as a result of the panel test, the alcohol concentration in the experimental group was significantly lower than that of the control group.After 30 minutes of alcohol consumption, the alcohol concentration immediately after alcohol consumption was significantly increased. In the case of one experimental group drinking the composition of the example, it was confirmed that the alcohol concentration was significantly reduced.

(Experimental Example 2)-Hangover symptom relief effect

A clinical experiment was conducted to find out the hangover relief efficacy of the present invention prepared through the above examples.

In order to reduce the significant difference, the test subjects were 10 healthy men (5 control group, 5 test group) of the same age, and experienced drinking alcohol from 10 days before this experiment for accuracy of the experiment. Was not allowed. In addition, in order to equalize the degree of drinking, men with similar alcohol consumption were asked to consume the same amount of alcohol (1 bottle of soju, 360ml, 19.5% Alc) over the same period of time (2 hours) and 5 hours after drinking. Evaluated. Hangover relief effect evaluation items were headache, nausea, thirst, tiredness, and vomiting. The results were scored and averaged on a 5-point scale.

division headache Vulgarity thirst Tired Vomiting Control 1.8 1.0 1.5 2.0 2.5 Experimental group 4.2 4.0 3.8 4.0 4.2

*Scoring criteria: 1. Very bad 2. Poor 3. Moderate 4. Good 5. Very good Control group: The group who only drank alcohol and did not take any recovery agents

Experimental group: group taking the complex extract for relieving hangover and improving liver function of the present invention

Experimental results show that the group taking the hangover relief and liver function improvement prepared by the method of the present invention has a satisfactory and significant effect in improving the hangover relief phenomenon caused by alcohol consumption compared to the group not taking the extract of the present invention. It turned out.

That is, the effect of the experimental product of the present invention on the hangover of alcohol showed a great effect on the hangover symptom index of the subject. In almost all of the query items, the test product showed a better degree of improvement than the control product, and statistical significance was observed in all evaluations by detailed item, confirming that the effect was evident.

The present invention described above is not limited to the above-described embodiments, since various substitutions and modifications can be made within the scope of the present invention to those of ordinary skill in the art. .

Claims (4)

In the method for producing a hangover relief complex fermented extract,
It contains a large amount of various inorganic salts of iron, potassium, iodine and vitamins A and C in the fermented extract of Hwangchil tree leaves and branches that have various physiological activities such as hangover relief, fatigue recovery, liver cell protection, antioxidant activity, and immunity enhancement. It is mixed with a fermented extract of Maesengi fermentation, which has the effect of relieving hangovers, preventing and sedating gastric ulcers or duodenal ulcers, lowering cholesterol and treating constipation, but using a two-stage sequential two-stage fermentation, fermented at low temperature with useful microbial culture medium in which microorganisms have grown as much as possible. Fermented extracts of rice bran fermented with high alcohol-degrading enzyme activity are added to enhance GABA (gamma-ammino butyricacid), and fermented extracts of Hwangchil, Maesengyi, and Rice bran are composed at the same amount (weight ratio). A synergistic effect through interaction through high alcohol metabolism accelerating action by containing a large amount of natural GABA (gamma-ammino butyricacid) in the efficacy of the Hwangchil fermented extract for relieving hangovers that help decomposition of aldehyde components and the fermented extract of Maesengi fermentation for alcohol decomposition Gaba enhancement complex functional foods effective in relieving hangovers by mixing fermented extracts as essential constituents as an essential ingredient. Gaba enhancement complex functional foods fermented extracts with phenol and phenol as a natural product that performs antibacterial and bactericidal action The antioxidant function is further reinforced by selectively adding gardenia extract or turmeric extract containing a large amount of flavonoids,
In addition to its excellent antioxidant effect, it is effective in removing hangovers because it is rich in amino acids such as vegetable fiber, taurine, iron and calcium, and increases the content of Gaba (gamma-aminobutyric acid) to further increase the yield of GABA (gamma-ammino butyricacid). In order to realize the effect of relieving hangover after drinking through high alcohol metabolism promotion effect by increasing and containing a large amount of natural GABA (gamma-ammino butyricacid), it activates the gaba receptor and is a seaweed rich in polyphenols. Optionally add,
In addition, in order to further reinforce the hangover relieving function, herbal extracts consisting of licorice, jujube, cinnamon, ginger, angelica and brown root, which are used as a solubilizing agent for poorly soluble substances as a natural herbal medicine for relieving hangovers, are added.
Aspartic acid and citric acid-rich pears and plums are formed by adding and mixing 5 parts by weight of each as a supplement to 100 parts by weight of the Gaba-enhanced complex functional food ferment extract as the main ingredient. Method for producing complex fermented extract for relieving hangovers containing fermented extract The method of claim 1,
The Hwangchil fermented extract is selected from Hwangchil tree leaves and branches in a weight ratio of 1:3, finely chopped, and washed with functional water containing nanobubbles having sterilization, antibacterial effect, anthelmintic effect, and cleaning effect to remove impurities and bacteria. Unlike the following hot air drying, it is a fast drying process using far-infrared radiation energy that increases antioxidant activity by emitting a wavelength in the range of 2 to 14㎛, minimizing damage to saponin components, while fermenting the leaves and branches of Hwangchil tree with far-infrared treatment effect. To enhance the ingredients, cut the leaves and branches of Hwangchil tree from which moisture has been removed by drying at a temperature of 40-50℃ in a far-infrared sterilization dryer with a moisture content of 8-10% for 2 hours at a temperature of 40-50℃. In order to minimize the destruction of nutrients, it is freeze-dried and dried in a freeze-drying method, and it is pulverized in an air-flow type grinder so that there is no frictional heat or nutrient destruction, and then pulverized into fine powder, and includes a cyclone that collects the powder. It is classified with a double-type cyclone classifier that separates coarse powder, but the cell wall is destroyed in the state of nano-sized ultra-fine particles of 20 ㎛ or less by pulverizing a closed circuit system that repeats the pulverization operation 5 times and classifies it into nano-sized ultra-fine particles. A compound consisting of Bacillus subtilis, a lactic acid bacteria strain and yeast that improves liver function and decomposes proteins by 5 parts by weight compared to 100 parts by weight of the powdered Hwangchil mixture as a fermenting microorganism in the powdered Hwangchil mixture of powdered Hwangchil tree leaves and stems. 5 parts by weight of wild grass enzyme or carbohydrate degrading enzyme, protein decomposition that promotes microbial activity with a complex synergistic effect in which the components are organically and complementarily combined by interacting with the fermenting microorganism and the complex fermenting microorganism to overcome the limitation of application of the microorganism Fermentation of a bio-ceramic material that increases the activity of active ingredients during fermentation by emitting far-infrared rays and forming micropores to breathe through a complex enzyme containing enzymes and lipolytic enzymes for promoting microbial activity. Mix each in a tank and ferment at low temperature for 48 hours so that the active ingredient is not destroyed in an enzyme fermentation tank at a temperature of 20℃ to 40℃ to enhance the antioxidant effect to enhance the pharmacological activity of Hwangchil and extract total polyphenols as an active ingredient. Method for producing a hangover-relieving complex fermented extract in which a mixture of Hwangchil tree fermented extract and Maesengi fermented extract, characterized in that it forms a fine powdered Hwangchil tree fermented extract that can increase The method of claim 1,
The fermented extract of Maesamsaengi is selected and immersed in purified water for at least 30 minutes, and then washed three times with flowing functional water containing nanobubbles that have sterilization, antibacterial effect, insect repellent effect, and cleaning effect to remove impurities and bacteria. After removal, it is a quick drying process using far-infrared radiation energy to increase antioxidant activity by emitting a wavelength in the range of 2 to 14㎛. Dry with a moisture content of 8-10% for 2 hours at 40-50℃ in a far-infrared sterilization drying device. A cyclone that freezes and dries the removed mesaengi in a freeze-drying method to minimize the destruction of nutrients below -20℃, and pulverizes it in an air-flow type grinder so that there is no frictional heat or destruction of nutrients, and then pulverizes it into fine powders. It is classified with a double-type cyclone classifier that separates the coarse powder from the powder collected by the cyclone, but repeats the pulverization operation 5 times to classify it into nano-sized ultra-fine powder. Natural glutamic acid derived from a complex fermentation microorganism consisting of 5 parts by weight of Bacillus subtilis, a lactic acid bacteria strain and yeast, and a natural glutamic acid ( 5 parts by weight of wild grass enzyme or carbohydrate degrading enzyme, proteolytic enzyme, lipolytic enzyme that interacts with the complex fermentation microorganisms that convert glutamic acid) into GABA (gamma-ammino butyric acid) to promote microbial activity Complex enzymes for promoting microbial activity are mixed in a bio-ceramic fermentation tank and fermented at a low temperature for 48 hours to prevent destruction of the active ingredients in the enzyme fermentation tank at a temperature of 20℃ to 40℃ to enhance the antioxidant effect. Method for producing a hangover-relieving complex fermented extract comprising a mixture of fermented extract of Hwangchil tree and fermented extract of Maesengi, characterized by forming fermented extracts The method of claim 1,
The Gaba-enhanced rice bran fermentation extract is 30 parts by weight of sugar, 30 parts by weight of glucose, 20 parts by weight of potassium chloride, 5 parts by weight of sodium hydrogen carbonate, acetyl salicylic acid, based on 100 parts by weight of purified water heated to 50 to 60°C. As a rice bran fermentation strain with excellent ability to produce GABA (gamma-ammino butyric acid), the culture medium formed by stirring and heating including 5 parts by weight and 10 parts by weight of citric acid is added to the bio-ceramic (Bio-Ceramic) by adding complex useful microorganisms consisting of lactic acid bacteria, yeast and Bacillus bacteria. ) In a fermentation tank made of material, the microorganisms are maximally proliferated by expanding and culturing them in two stages for 30 to 50 hours at a temperature of 20 to 40°C. A method for preparing a hangover-relieving complex fermented extract comprising a mixture of Hwangchil tree fermented extract and Maesengi fermented extract, characterized in that it forms a Gaba-enhanced rice bran ferment extract with high alcohol-degrading enzyme activity