KR20200046931A - The process of making healthcare composition for relieving and preventing alcoholic hangover comprising fermented Dendropanax morbifera extract and Capsosiphon fulvescens extracts - Google Patents

Abstract

The present invention relates to a method for manufacturing a hangover relieving and liver function mitigating composite fermented extract formed by blending a fermented Dendropanax morbifera extract and a fermented Capsosiphon fulvescens extract. According to the present invention, pharmacological activity of the fermented Dendropanax morbifera extract is increased by fermenting leaves and branches of Dendropanax morbifera which is a unique plant resource of Korea and has various proven pharmacological activities such as hangover relief, fatigue recovery, liver cell protection, anti-diabetic activity, antioxidant activity, immunity enhancement, and the like. Moreover, the fermented Capsosiphon fulvescens extract contains a large quantity of various kinds of inorganic salts, such as iron, potassium, iodine, and the like and vitamin A, C, and the like to provide effectiveness such as hangover relief, prevention and mitigation of a stomach or duodenal ulcer, cholesterol lowering, growth promotion for children, constipation treatment effectiveness, and the like. The method blends the fermented Dendropanax morbifera extract and the fermented Capsosiphon fulvescens extract to complementarily realize synergy effect without lowering physical properties and losing active ingredients of both the extracts. Accordingly, functions of the mixture are complexly increased, thereby providing a pharmacological activity more reinforced than an original pharmacological activity.

Description

The process of making healthcare composition for relieving and preventing alcoholic hangover comprising fermented Dendropanax morbifera extract and Capsosiphon fulvescens extracts}

The present invention relates to a method for preparing a complex fermentation extract to improve hangover function and improve liver function by mixing a fermented extract of hwangchil tree and fermented fermentation extract,

In more detail, our unique plant resources enhance the pharmacological activity of hwangchil tree by fermenting hwangchil tree leaves and branches with various physiological activities, including hangover relief, fatigue recovery, hepatocyte protection, anti-diabetes, antioxidant activity, and immunity enhancement. Fermented hwangchil tree ferment extract contains a large amount of various inorganic salts such as iron, potassium, and iodine, and vitamins A and C to relieve hangover, prevent and soothe stomach ulcers or duodenal ulcers, lower cholesterol, promote children's growth, and treat constipation As the composition is mixed so that the plum blossoms having the efficacy of the back can complement each other synergistically without deterioration of each physical property or loss of the active ingredient, the function is compounded and the enhanced effect can be realized than the original pharmacological effect. Excellent to effectively prevent hangover caused by (過 飮) It is a health functional composition for improving hangover and improving liver protection, which has improved alcohol decomposition activity of new composition that has not been used in the past, and has improved ability to relieve hangover and improve liver function by mixing Hwangchil tree fermented extract and Maesus extract. It relates to a method for producing a complex extract.

Alcohol is a popular drink in both the East and the West, but when consumed in excess, it not only harms the individual mentally or physically, but also causes social problems. The trend is to avoid frequent drinking.

Therefore, due to the nature of the drinking culture that is easy to drink too much, most ordinary drinkers complain of various discomforts such as headache, fatigue, and vomiting due to hangover the next day. Hangover refers to uncomfortable physical and mental symptoms that occur between 8 and 16 hours after drinking alcohol. It is caused by the action of acetaldehyde, which occurs when alcohol breaks down. Main symptoms include headache, gastroenteritis, vomiting, dizziness, It causes socio-economic loss by reducing work efficiency due to muscle pain, etc., and having various negative effects on normal life. Therefore, due to these problems, interest in drinks or drugs that can remove hangovers is amplified.

In particular, symptoms such as hangover and memory impairment during excessive drinking are due to the fact that acetaldehyde, which has not been completely decomposed during alcohol metabolism, remains in the body and stimulates the cerebellum and cerebrum. Alcohol is more fatal to the brain than the liver. Research to reduce hangovers or diseases mainly caused by brain problems, such as decreased memory due to drinking, triggered headaches and dizziness, and anger control disorders, is also being actively conducted.

Hangover is a group of symptoms that occurs after metabolism is complete after taking alcohol. Symptoms are largely divided into physical and mental symptoms. Physical symptoms of hangovers include headache, fatigue, sensitivity to irritation, diarrhea, loss of appetite, vomiting, tremors, and dizziness, diminished work ability and cognitive function, depression, anxiety, and excitement. As a causative agent of hangover, acetaldehyde, an alcohol metabolite, acts as a major toxic substance, and it has been reported that a large amount of free radicals are generated in the process of alcohol metabolism, which is a major cause of alcoholic disorders.

Gaba (GABA) is an amino acid and a neurotransmitter that is effective in controlling seizures or depression and lowering blood pressure (these blood pressure control effects are complications caused by diabetes, improvement in liver and kidney function, prevention of obesity, menopausal disorders, generalized asthenia, Improves headache, etc.), promotes brain cell metabolism (enhances learning ability), increases memory, relieves stress, relieves pre-menstrual tension, and strengthens immunity.

In addition, it is reported that if the GABA content in the brain is reduced, it is highly likely to cause alcoholic brain disease.

Conventionally, bean sprouts, drumfish, mung beans, and the like have been used as foods to relieve hangovers after drinking to relieve hangovers. In particular, bean sprouts are rich in aspartic acid, which is known to protect the liver by promoting the breakdown of alcohol by helping the action of acetaldehyde (ADH), and beverages to relieve hangovers containing aspartic acid are also commercially available, but these folk remedies have an alcoholic decomposition effect. Most of them are used without scientific verification of them. Recently, a scientific approach to alcohol decomposition effect of several substances has been made.

In addition, many studies have been conducted to find a drug that can reduce hangover, and many drugs have been introduced, but not many have a remarkable effect. Even if it is effective, it is a synthetic chemical that shows toxicity and side effects. Unsuitable Therefore, there is a desperate situation in research to find a substance that helps to relieve hangover from natural substances and to prove its effectiveness scientifically.

That is, in relation to the removal of hangovers before and after drinking, various health supplements containing ingredients extracted from natural foods or herbal ingredients have been developed for the purpose of eliminating hangovers and protecting the stomach, but they are effective only for some symptoms among various hangover symptoms caused by drinking Or hangover relieving effect was found to be insignificant.

Conventional health supplements using hangover-releasing natural products have a hangover-relieving effect, but they reduce the digestive function and alcohol degradation metabolism of nutrients in the stomach or small intestine due to drinking, and are taken due to the unique aroma and taste of herbal medicines. It is difficult to do this, and if left unattended for a long time, there are problems such as the appearance of sediment, which is visually unfavorable. Development of a new hangover-relieving product that can be effective is in progress.

However, despite the various efforts to relieve hangover after drinking as described above, the development of foods that can effectively relieve or relieve hangover is still insignificant compared to the demand, and the hangover is resolved without any side effects and sufficiently effective. Development of food is required.

Recently, simple ingredients that contain hangover-relieving functional ingredients such as aspartic acid

In addition to hangover-relieving beverage products, the development of functional foods for hangover-relieving functional foods with complex functions such as fatigue recovery and gastrointestinal protection as well as hangover is becoming more diverse.

Fermented food refers to food produced through the fermentation process, and numerous functional fermented foods including functional substances beneficial to the human body generated as a result of fermentation have been introduced. In particular, functional fermented foods containing a large amount of total polyphenols and flavonoids have been introduced in relation to strengthening liver function, and these functional fermented foods are excellent in antioxidant activity and bioactivity related to liver function enhancement, DPPH radical scavenging ability, and ABTS radical scavenging ability evaluation results. Showed activity.

In addition, fermented foods are economical foods that have excellent food storage properties and ensure preservation and hygiene safety. By fermenting foods, high-molecular substances are decomposed into low-molecular substances to increase digestion and absorption, and palatability increases through the creation of new flavors.

In addition, a component having a physiological activity is generated, and recently, research on useful substances having a tertiary function effect in fermented foods and research on fermentation metabolism have been actively conducted.

As hwangchil tree has no place to throw away the entire tree, it has high economic value, green plantation of natural environment recovery, and is definitely an excellent plant of one stone and two that has a pharmacological effect in addition to its action as a paint.

The components of Hwangchil are composed of 66.7% of non-volatile components, 10.8% of aromatic components, 8.1% of moisture, and 14.4% of solid components, which are the coating components that form the golden coating film. Aroma components mainly consist of β-cubebene, γ-selinene, and δ-cardinene of sesquiterpenes, and these components are yellowed by showing sedative and tonic effects on the nervous system. This antioxidant, anti-hypertensive, anti-cancer, and hepatocellular protective effect is known to be effective in preventing, treating, and improving diseases of increasing severity in modern society. It can be seen that it can be used not only as a medicine, but unlike lacquer, it does not cause skin allergies and is easy to handle, so it can be widely used as a health food by appropriately processing Hwangchil.

 Therefore, the above-mentioned Hwangchil extracts various effective ingredients through analysis of the resin composition composition of Hwangchil tree. Recently, as various health promotion and treatment effects are known, its use is gradually expanded, and various functional beverages, pharmaceuticals, etc. New applications are pioneering.

Hwangchil-tree is considered to be one of the three medicinal plants using the same name as Panax, along with the same elm family Panax ginseng and Acacthopanax. The value of Hwangchil tree is soaring as research papers that prove various functions such as suppressing damage, improving blood cholesterol, improving immunity, and skin whitening effects have been recently released.

In particular, Hwangchil improves liver function, relieves hangover, recovers fatigue, and has various detoxification effects, and is found to be effective when it is helpless and unwilling to replace or combine with existing treatments for the purpose of preventing and treating diseases related to hepatocyte protection. So you can use it with confidence

Hwangchil tree is also excellent in improving liver function, and when it is administered with Hwangchil extract, it has excellent liver protection effect and excellent hangover. In particular, it has no special side effects, even though it has a protective effect on hepatocytes, and can be used for the purpose of preventing and treating diseases related to hepatocyte protection, such as fatty liver, hepatitis, cirrhosis, etc.

However, the clove ingredients such as sesquiterpene included in hwangchil have various pharmacological effects as well as their value as a scent that makes the mind and body clear and comfortable, but studies to maximize the efficacy of hwangchil have been actively conducted, but as herbal medicine Hwangchil has a function as a medicinal material, but it is not easy to ingest itself, it is difficult to process raw materials, and its pharmacological activity is not strong per unit weight.

In recent years, as various physiological and functional effects of seaweed have been revealed among natural products, research on physiologically active substances separated from seaweed has been actively conducted, and a movement to develop and utilize its function as a high-value-added product has been active. It has been reported that polysaccharides and glycoproteins, as well as proteins, vitamins, and minerals, as constituents of seaweeds have antiviral and anticancer effects and immune activity.

In particular, as seaweeds have recently been verified for various physiochemical effects, interest in physiologically active substances derived from seaweeds is growing, and because of the abundant dietary fiber, research for prevention of hypercholesterolemia and development of therapeutic agents is actively underway. Algae, one of the representative low-calorie foods, has been reported to prevent arteriosclerosis, myocardial infarction, hypertension, and stroke, which are the causes of adult diseases, and to suppress aging of alginic acid, a representative bioactive substance of brown algae, and to inhibit intestinal absorption and anticancer effects of heavy metals. have.

Seaweeds are divided into red algae, green algae and brown algae according to their color, that is, photosynthetic pigment. Brown algae include seaweed, dashima, 톳, caps, persimmon, moxibustion, and apocalypse. Red algae refers to seaweed, walnuts, and tailtails. Green algae are known to have plums, greens, and hearing, and among green algae, greens, greens, and greens, glucuronoxylorhamnan is known to be effective in reducing cholesterol in the blood.

As a specialty product of the South Island region that grows only in clean and clean waters like Gangjin and Wando, Jeonnam, Maesongi is a natural seaweed hangover reliever that is rich in dietary fiber and taurine and soothes bitter stomach after drinking. Capsisiphon fulvescens Is an annual algae that is nutritionally low-calorie, low-fat, high-protein, high-calcium, high-iron, high-fiber, high-chlorophyll food, widely distributed all over the world, and in Korea, the south coast or the West Sea where the intrinsic environment of Jangheung, Jeonnam and Wando is predominant. It lives on the southern coast. The crude protein content, especially the essential amino acid content, is higher than other seaweeds, and contains minerals such as Fe and Se, as well as vitamin A, C, and ω-3-based fatty acids.

 Maesongi, also known as the 'algae noble', is also a typical Haejang menu. It has a strong sweetness and a deep aroma, and it is seasonal between December and February every year. Although it differs in general ingredients and mineral content depending on the sampling time, it is about 50% sugar. In addition to its excellent palatability as a food containing 35% protein, it has a high hangover effect and a high utilization value of physiological functional substances such as anti-cholesterol, and asparic acid, which is good for resolving hangovers, is three times higher than sprouts, and contains vitamins, minerals, carbohydrates, protein, fat It is also good for growth and development and prevention of constipation.

        In particular, Maesi-i is sensitive to environmental pollution and grows only in clean waters. Although it is a resource that can increase added value with eco-friendly food materials and health-functional food ingredients, it is not possible to collect natural aesthesia except in winter. There is a need for a new processing method to satisfy the consumer's desire because it is necessary to increase the availability through the development of a safe food product capable of exhibiting the original effect of natural spontaneity and obtaining functional substances.

      In other words, Maesongi is a food produced only from December to February every year and has a unique aroma and taste, and has been a favorite for food since long ago. In addition, it is rich in minerals and vitamins, and is not only good for children's growth and development, but also known as a seaweed that lowers cholesterol and effectively prevents high blood pressure. It is very sensitive to environmental pollution, and when pollutants enter the land, its growth decreases and its organic acid content There is a problem that the production volume is lowered because it melts even if there is a little.

        In addition, due to the ecological characteristics that grow in the intertidal zone of the coastal area where the water depth is light, various organic and inorganic odors are caused when the sanitary soil is not thoroughly cleaned due to the characteristics of contaminant contaminants in various organic and inorganic foreign substances derived from the soil of the tidal flats. Therefore, it is difficult to expect the intrinsic flavor characteristics to be expressed, and there is a characteristic that the preservability in the fresh state is also poor.

       The literature that introduces the prior art is as follows, and since it does not have the same effect as expected, the effect of relieving hangover and preventing it, as well as recovering from fatigue after drinking and improving intestinal health and improving memory are realized. It has a variety of problems that do not meet the characteristics of general use as a functional composition for preventing and controlling hangover, which must satisfy the various needs of consumers at once.

 Document 1: Republic of Korea Patent Publication No. 10-2007-0101443

(Composition for relieving hangovers containing mixed herbal extracts as an active ingredient, published on October 17, 2007)

         Document 2: Republic of Korea Patent Publication No. 10-2004-0097112

       (Hwangchil extract with hepatocyte protection effect, health supplement using hwangchil fraction as an active ingredient, November 17, 2004)

       Document 3: Korean Registered Patent Publication No. 10-0834870

      (Maesiyi extract manufacturing method and health food using the same, May 28, 2008)

 Accordingly, the present inventors have researched to develop a composition for resolving a new hangover, which has excellent efficacy for alleviating hangover caused by drinking without side effects on the human body. It is an ideal combination of natural vegetable ingredients that help to relieve fatigue, improve liver function, and promote blood circulation by including extracts. It is an effect that the function of the composition is increased by mixing the extract at an appropriate concentration so that each extract can synergistically complement each other without deterioration of each physical property or loss of an active ingredient. Fatigue recovery and intestine And it completed the present invention to implement a combination of a steel recovery effect.

 When used as described above, the hwangchil tree extract or plum extract of the prior art, each of which has functional characteristics, and the herbal medicine extract alone, relieves and prevents hangover caused by excessive drinking, recovers from fatigue after recovery and recovers intestinal health And it has a problem in realizing all the symptoms of complex symptoms, such as memory improvement effect,

Proper concentration so that each functional active ingredient has an enhanced effect than the pharmacological effect of the original, so that Hwangchil tree extract and Maesus, which have good compatibility with each other, can complement each other synergistically without deteriorating their physical properties or losing active ingredients. By mixing the composition with the effect of increasing the function in combination, it is possible to satisfy various needs of consumers at once, which not only has a hangover effect when ingested before or after drinking, but also can realize fatigue recovery and intestinal health recovery after drinking. The present invention solves the technical problem of developing a complex extract for relieving hangover and improving liver function as an additive that interacts with the Hwangchil tree fermentation extract as an additive.

The present invention has been made to solve the problems of the prior art described above,

Efficacy effect is fragmentary or limited, and it is possible to break away from the hangover relieving composition of the prior art, which was only expected to have partial effects on hangover diseases of various symptoms.

Hwangchil tree, which enhances the pharmacological activity of hwangchil tree by fermenting hwangchil tree leaves and branches with various physiological activities such as relieving hangover, restoring fatigue, protecting hepatocytes, anti-diabetes, antioxidant activity, and immunity, so that loss of functional components is minimized. Fermented extract contains various inorganic salts such as iron, potassium, and iodine, and vitamins A and C, which helps to relieve hangover, prevent and soothe stomach ulcers or duodenal ulcers, lower cholesterol, promote children's growth, and treat constipation. By mixing the composition so that each of the extracts having efficacy can complement each other synergistically without deterioration of each physical property or loss of an active active ingredient, the function is multiplied and it can realize an enhanced effect than the original pharmacological effect. Excellent efficacy to effectively prevent hangover caused by) It is a health functional composition for improving hangover and improved liver protection, which has improved alcohol decomposition activity of a new composition that has not been used in the past and has been used in a complex way. It is an object to provide a method for producing a fermented extract.

As described above, the hwangchil tree fermentation extract according to the present invention and the hangover solution and the liver function improvement complex fermentation extract, which is a mixture of plum extract, are not only hangovers, but also hangover relievers that consider fatigue and recovery of intestinal health after drinking.

Fermented hwangchil tree leaves and branches with various physiological activities, including hangover relief, fatigue recovery, hepatocyte protection, anti-diabetes, antioxidant, and immunity enhancement, fermented hwangchil tree fermentation extract, iron, potassium, It contains various mineral salts such as iodine and vitamins A and C, so it has a high level of anti- hangover effect, prevention and sedation of gastric ulcer or duodenal ulcer, lowering cholesterol, promoting growth of children, and constipation treatment. By mixing the composition so as to complement each other synergistically without deterioration of each physical property or loss of active ingredients, the function can be compounded and the enhanced effect can be realized than the pharmacological effect of the original. 효능) to realize the excellent efficacy to effectively prevent.

Particularly, the present invention solves the conventional hangover that contains each component alone by adding the hangover effect of the extract to the hangover of the hwangchil tree fermentation extract having excellent homeostatic action to maintain normal body function. And Hwangchil tree and Maesus extracts maximize the benefits of this extract than the extract that improves liver function, and relieves hangover and improves liver function, thereby suppressing headache, diarrhea, loss of appetite, nausea, vomiting, chills, and cold sweat. Or it can decrease, and recover the body from lowering cognitive ability and lowering motor ability, and can maintain hematologic and hormonal normal state. When applied, it will perform a wide range of hangover relief.

In the end, the composition for relieving hangover of the present invention can exhibit the same or better hepatic cell protection and liver function improvement effect while containing each active ingredient in a reduced content due to the synergistic effect of each active ingredient included therein. It is possible to greatly reduce the risk of side effects due to the high content of ingredients, and it can exhibit excellent liver function improvement effect, improves deteriorated liver function, and protects or heals liver damage caused by excessive drinking or chronic alcohol consumption. Excellent, it has a very excellent function of lowering the alcohol level in the blood by promoting alcohol metabolism after drinking, and has an effect of enhancing the antioxidant capacity in the body, thereby improving liver function when the composition of the present invention is eaten and consumed in food form. , Protects liver damage from excessive alcohol or chronic alcohol consumption, and increases blood alcohol level It can reduce and also improve the antioxidant capacity in the body, and at the same time, can relieve all symptoms associated with typical hangovers such as headache, heartburn, thirst and bad breath.

In addition, the present invention maximizes the advantages of hwangchil tree during fermentation. The cell membranes of hwangchil tree branches, leaves, fruits, and roots are destroyed, and the active ingredient contained by crushing microorganisms is soluble in water, and the dissolved fermentation product is in the body. It can be easily absorbed and promotes alcohol metabolism in vivo, thereby lowering the concentration of alcohol and acetaldehyde to effectively remove hangovers caused by alcohol intake, so it can be widely used to solve hangover symptoms caused by excessive alcohol intake. You can.

In addition, the composition according to the present invention is effective in improving the liver protective function by providing the stability of the formulation by having the optimum mixing ratio, preventing and eliminating hangovers, supplying nutrients necessary for the liver, improving blood circulation, and improving chronic fatigue. .

In particular, the composition for relieving hangover of the present invention can be used as a hangover reliever because it reduces the alcohol concentration and acetaldehyde concentration in the serum at the initial stage of alcohol ingestion, and can be used as a fatty liver preventive agent because it reduces induction to fatty liver when ingesting alcohol for a long time.

That is, the composition for releasing a hangover of the present invention increases the activity of the alcohol dehydrogenase, greatly reducing the blood concentration of alcohol, and at the same time suppressing nerve damage caused by alcohol, promoting the activation of brain function along with the effect of releasing the hangover and alcohol In case of excessive drinking or regular drinking, it inhibits the damage of cognitive function, which is usually caused, and solves the phenomenon of blackout after drinking.

Therefore, the present invention is to maintain the health by allowing the body state to be maintained in a normal state before or after the hangover occurs, and by fermentation, the bitter taste and odor of the herbal medicine material are removed to improve drug compliance and extract the effective ingredient of the medicine And increase the absorption by the body.

In addition, the composition according to the present invention is hygienically manufactured with an ideal blend of natural vegetable raw materials to help smooth modern people, improve fatigue, improve liver function, and improve blood circulation. The present invention relates to a method for preparing a complex extract of granules, powders, pills, capsules and tablets, or to relieve hangovers in the form of beverages and to reduce hangovers and improve liver function.

The present invention does not harm the liver and lowers the concentration of acetaldehyde, an alcohol metabolite as a substance causing hangover, and the residual alcohol concentration remaining in the body, resulting in headache, fatigue, irritation sensitivity, diarrhea, loss of appetite, and vomiting. It is possible to comprehensively solve dizziness, depression of work ability and cognitive function, depression, anxiety, and excitement, which are mental symptoms such as tremor.

In the end, the composition of the present invention has a high content of polyphenols and flavonoids, relieves hangovers through decomposition of acetaldehyde, and emits alpha waves, which are brain wave substances, as a restorative effect that stabilizes nerves. It contains glycogen (a polymer of glycogen / glucose) that helps metabolize acetaldehyde, and contains a functional mixture of low-molecular ginsenosides and gaba (GABA), which is a mixture of extracts that help alcohol breakdown. In addition to the main purpose of recovery, it will be beneficial for secondary liver function improvement, liver damage suppression, liver disease prevention, antioxidant effect, gastric function improvement, brain disease prevention, etc.

When describing the configuration of the present invention to achieve the above object in detail as follows.

All technical terms used in the present invention, unless defined otherwise, are used in the sense as commonly understood by those skilled in the art in the relevant field of the present invention. In addition, although a preferred method or sample is described herein, similar or equivalent ones are included in the scope of the present invention.

The present invention is a variety of inorganic salts such as iron, potassium, iodine and vitamins A and C in the hwangchil tree fermented extract of hwangchil tree leaves and branches, where various physiological activities such as relieving hangover, restoring fatigue, protecting hepatocytes, antioxidant activity, and enhancing immunity are revealed. Since it contains a large amount of back, it is useful to proliferate microorganisms as much as possible through the fermentation of fermented extract, which has the effects of hangover relief, prevention and sedation of gastric ulcer or duodenal ulcer, cholesterol lowering action, growth promotion effect for children, and constipation treatment efficacy. Low-temperature fermentation with microbial culture enhances GABA, further adding rice bran fermentation extract with high alcohol-degrading enzyme activity, so that fermentation extract of hwangchil, maesan, and rice bran is formed in the same amount ratio (weight ratio), and acetase is increased by the fermentation process. Helps to decompose hangover to help decompose aldehyde components Gives the effect of fermentation extract to the effect of fermentation extract, a high-concentration gaba-promoting complex functional food fermentation extract that is effective in resolving hangover through synergistic effect through interaction through high alcohol metabolism promoting action by containing a large amount of natural GABA is mixed as the main ingredient of essential ingredients However, as a natural ingredient that performs antimicrobial and antiseptic functions as a supplementary ingredient for functional enhancement to supplement the functionality of the gaba-enhancing complex functional food fermentation extract, select a gardenia extract or turmeric extract containing a large amount of phenol and flavonoids (Quercetin-QUERCETIN) To further enhance the antioxidant function,

In addition to its excellent antioxidant effect, it is rich in amino acids of vegetable fiber, taurine, iron, and calcium, which is effective in removing hangovers and enhances the content of gaba (gamma-aminobutyl acid), further increasing the yield of GABA and producing a large amount of natural GABA. Through the high alcohol metabolism promoting action according to the content, it activates the Gaba receptor to realize the effect on the hangover after drinking and selectively adds persimmon extract and kelp extract as a seaweed rich in polyphenols.

In addition, in order to further strengthen the hangover-relieving and hepatocellular protective function, an herbal extract made of licorice, jujube, cinnamon, ginger, Angelica and brown root, which is used as a solubilizer for poorly soluble substances, is also added.

Bioavailability and bioavailability by forming a fruit extract consisting of pears and plums, which are rich in aspartic acid and citric acid, which improve liver function, by adding 5% by weight of the main raw material as an auxiliary ingredient to the fermentation process and mixing them to easily share the ingredients By improving the physiological activity and effectively improving hangover and liver function, various healthy ingredients with excellent taste and aroma can be easily and conveniently taken together, so that the damaged liver and liver before and after drinking can be quickly recovered through synergism of each active ingredient. The present invention relates to a method for preparing a complex fermentation extract that improves liver function and relieves hangover, which is a mixture of a fermented extract of hwangchil tree that is beneficial to health and fermented extract.

In the present invention, a mixed raw material including a hwangchil fermentation extract to help decompose acetaldehyde components and a rice bran fermentation extract extracted from natural rice bran rich in gaba rich in fermentation to help decompose alcohol as a main raw material and interact In order to further enhance the antioxidant effect, hangover relief, fatigue recovery, and liver function protection effect as a supplementary material that realizes a complex synergistic effect, it is a herbal medicine for hangover remediation, which includes herbal extracts made from licorice, jujube, cinnamon, ginger, Angelica and brown roots and gaba As a seaweed that activates receptors, it adds persimmon extract and kelp extract and fruit extract consisting of pear and plum selectively and shares its function. Besides the main purpose of relieving hangover, it has secondary effects such as fatigue recovery, gastrointestinal protection, liver function improvement, liver damage inhibition, Prevention of liver disease, antioxidant effect , Comprehensive functions such as improving stomach function and preventing brain disease will be comprehensively performed.

In the present invention, the fermented extract of Hwangchil and Maesi is a natural fermentation product that enhances the pharmacological activity of Hwangchil tree by fermenting Hwangchil tree leaves, branches, and plums by a low-temperature extraction method that optimizes active ingredients. During the process, the cell membranes such as hwangchil tree leaves, stems, and plums are destroyed, and microbes are crushed to effectively dissolve the active ingredients contained in them and the dissolved fermentation products are easily absorbed by the body. Because it is relatively low, it is possible to prevent the useful component from being destroyed or deteriorated by heat.

Particularly, the present invention is a fermentation strain having an excellent gaba generation ability to overcome the limitations of microbial application, and extracts with a complex synergistic effect due to complex enzyme fermentation in which each component, such as several types of microorganism groups and enzyme groups, are organically complementary to each other. By mixing the composition so that the active ingredients of each of the active ingredients complement each other synergistically without deterioration or loss, the functions are compounded to realize an enhanced effect than the pharmacological effect. The enzyme or monoenzyme is added to the Sanya herb enzyme or complex enzyme by adding a mixture of carbohydrate-degrading glycosidase, protein-degrading protease, and fat-degrading lipase. By doing so, the time required for the activation of microorganisms is shortened as much as possible and the yield of bioactive components is increased.

The functional complex extract for hangover relief of the present invention may be extracted with only fermenting microorganisms, but it is preferable to add a complex enzyme for promoting microbial activity, which contains a combination of wild plants, carbohydrate degrading enzyme, proteolytic enzyme, and lipolytic enzyme. When fermentation is performed by adding Sanya herb enzyme or complex enzyme to the fermenting microorganism, it is possible for the enzyme to proceed more quickly with the fermentation of microorganism, and Hwangchil tree, the main raw material of the present invention, inoculates microorganisms as a raw material having many antibacterial components and fermentation. Since the reaction may not be performed well even if it is carried out, it is preferable to add the Sanya herb enzyme or the complex enzyme to the fermenting microorganism to solve this problem.

In addition, by fermenting Hwangchil, Maesi-yi, rice bran, and Chinese herbal medicines, and then fermenting them, fermentation speed is improved without spoiling, and the digestion and absorption of active ingredients are improved by fermenting Chinese medicines or plums and grains. This ultra-fine powdering process includes a cyclone that collects powder after pulverizing Hwangchil or Maesil with an air-flow grinder and then powders it into powder, and classifies it into a double cyclone classifier that separates coarse powder from the powder collected by the cyclone. It is possible to use a composite raw material powder that is finely powdered into a nano-sized ultra-fine particle having a size of 20 μm or less by pulverizing a closed circuit system that repeats the operation 5 times to classify the nano-sized ultra fine powder.

In addition, the far infrared ray sterilization and drying using far-infrared radiation has a shorter heat exposure time than normal hot air drying, so the damage to the saponin component is reduced and the antioxidant activity is increased. Recently verified research shows that far-infrared treatment has been performed on glutamic acid (GLUTAMIC ACID) such as rice. It is known to increase γ-aminobutyric acid (GABA) by activating decarboxylase. In other words, when irradiating far-infrared rays, it is possible to induce the maximization of antioxidant power by freeing and activating low-molecular-weight antioxidants present in natural products, and at the same time, heavy metals and harmful substances can be removed through strong sterilization and purification of far-infrared rays.

In addition, in the present invention, the final complex fermentation product may employ a cryogenic ultra-fine grinding technique, a freeze-drying grinding method, wherein the freeze-dried grinding of the hardly degradable hwangchil tree leaves, branches and fibers in a state in which the absorption capacity is low in vivo is tough. It is made of ultrafine powder in which the cell wall is decomposed, such as cell wall degrading enzyme treatment in the rapid freeze dryer and crusher, to prevent the loss of nutrients due to heat and to ingest its own nutrients, thereby stabilizing chemical components compared to normal natural drying It is effective in reducing the moisture content and reducing the risk of deterioration.

In addition, the composition of the present invention is preferred to increase the activity of the active ingredient by fermenting and fermenting in a fermenter, such as a clay pot made of red clay that emits far infrared rays and breathes.

In addition, in the present invention, purified water is preferably nano-bubble water that promotes high-purity sterilization and decomposition of biodegradable organic matter.

That is, the purified water of the present invention is a nano-pore-sized bubble, and water-in-the-nano bubbles containing fine oxygen bubbles that are invisible to the naked eye can exist in the liquid over a long period of time, thereby purifying water quality and performing complex functions such as sterilization and deodorization. In addition, the sterilization effect that promotes high-purity sterilization and disintegration of non-degradable organic substances by the strong sterilization power is additionally performed.

Eventually, the fermentation composition prepared by the manufacturing method of the present invention is converted into a saponin form capable of being absorbed by the active ingredient such as saponin of hwangchil through complex enzyme fermentation such as archaea and lactic acid bacteria, and physiology such as broth or rice bran with low absorption in the body. The decomposition of the active substance and the fiber improves the absorption rate in the human body, reduces odor, and various enzymes (enzymes) contained in the enzyme fermentation solution can be ingested as it is, thereby improving digestive enzyme activity and antioxidant activity.

In addition, in the present invention, in order to further increase the yield of GABA, as a natural product containing glutamate, the licorice and kelp extracts are additionally reinforced in addition to each liquor to efficiently reduce the molecular weight to a state that can be absorbed by humans by fermentation. Through the high alcohol metabolism promoting effect, it has an effect on relieving hangover after drinking.

Therefore, the complex fermentation extract for relieving hangover and improving liver function according to the present invention has an increased alcohol fermentation efficiency by the fermentation process, and includes natural GABA derived from rice bran and seaweed as an active ingredient by using a fermentation strain having an excellent ability to produce GABA. In order to realize the physiological function of GABA, it overcomes the limitations of the conventional GABA raw material, which must be consumed in large quantities, and exhibits an effect on relieving hangover after drinking by promoting a high alcohol metabolism according to the content of natural GABA.

Gamma-Amino Butyric Acid (GABA) is known to be involved in regulating physiological functions such as promoting brain function, improving concentration, mental stability, and lowering blood pressure. As a general effect of GABA, it is an amino acid and is a neurotransmitter that is effective in controlling seizures or depression. In addition, it promotes alcohol metabolism and is effective in removing hangovers and lowers blood pressure (these blood pressure control effects improve complications due to diabetes, liver and kidney functions, obesity prevention, climacteric disorders, generalized asthenia, headaches, etc.), brain Cell metabolism promotion (learning ability improvement), memory increase, stress relief, women's pre-menstrual tension relief, strengthening of immunity, vision recovery, etc. are known.

As a main component of the present invention, hwangchil tree has been reported to be effective in many diseases such as blood circulation improvement (cholesterol, blood pressure), antioxidant (prevention of aging), liver function improvement (hangover, fatigue recovery, detoxification), immunity enhancement, and regeneration, The scientific value of hwangchil tree has been recognized as a nutritional value, pharmaceutical value, and therapeutic value.

The fermented extract of hwangchil tree of the present invention uses hwangchil tree, which is a safe natural preparation, and has no side effects on human body application and has remarkable antioxidant activity and hepatocellular protective effect, thereby exhibiting an excellent effect on relieving hangover and improving liver function.

In particular, flavonoids (Flavonoid, QUERCETIN) as a hangover-releasing component included in the hwangchil of the present invention rapidly decompose acetaldehyde, a causative agent of hangover, and prevent the formation of harmful free radicals (Free Radical) in the blood. Alcohol acts as an antioxidant and acts as an anti-inflammatory effect, anti-inflammatory effect, activating immunity, removing oral odor, strengthening blood vessels that expand and strengthen capillaries, and lowers GPT levels and protects the damaged liver. It prevents damage to various organs caused by ingestion and has an excellent effect in diluting the toxicity of alcohol metabolites, and the flavonoids are the main components of falsification. Will also improve.

As is well known, taurine is a sulfur-containing amino acid that is distributed in each part of the body, such as the liver, brain, heart, and muscle, and is widely known as an antioxidant that prevents oxidative damage along with cysteine.

In particular, in the present invention, by fermentation of Hwangchil, a saponin (ginsenoid) component that is beneficial for liver function recovery, and at the same time, far-infrared sterilization and drying using far-infrared radiation that emits wavelengths in the range of 2 to 14 µm is more heat than normal hot air drying. The exposure time is short, so the damage of the saponin component is less, and the antioxidant activity is increased.

Saponin (ginsenoid) component increases the amount of hormones that break down alcohol and activates liver function, so it has the effect of reducing the concentration of alcohol in the blood.

In particular, the present invention fertilizes hwangchil by using one or more useful microorganisms to increase the absorption rate of saponin, which is an active ingredient of hwangchil, and a component of glycoside structure saponin (ginsenoside) using microbial glycolytic enzymes or complex enzymes. By inducing conversion, it increases the nutritional and functional value.

In the present invention, the hwangchil tree can be used without limitation of resin, leaves, roots, fruits, etc. of the tree, but in the present invention, the hwangchil tree is used by mixing leaves and branches. For this, it is preferable to use the mixture ratio of hwangchil tree leaves and branches in a ratio of 7: 3 by weight.

In addition, the hwangchil tree leaves can effectively improve the leaching properties through a roasting treatment that increases the aroma.

Also, in general, seaweed is rich in vegetable fiber, taurine that improves liver function by lowering fatigue and lowering cholesterol, and is rich in amino acid components of iron and calcium, so it is effective in removing hangovers, as well as improving liver function and protecting the liver. After that, the damaged liver and liver can recover quickly, and it functions as a natural hangover reliever that suppresses oxidative damage to the brain.

Among the seaweeds, Capsosiphon fulvescens, which belongs to the genus Lepidoptera and Ancestral genus, is an annual seaweed that is widely distributed all over the world. The amino acid content is higher than other seaweeds, and it contains minerals such as Fe and Se, and also contains a large amount of vitamin A, C, and ω-3-based fatty acids, so it is nutritionally superior and has been used as a local food for a long time. Maesong exotic soup boiled with oysters is a representative food of Namdo, and has a unique flavor and sweetness, and is favored as a high-quality sea food.

In particular, it contains a high content of aspartic acid, which is good for relieving hangover, relieving fatigue, and detoxifying the liver.

Rice bran (Rice bran) is a by-product that occurs during the rice cultivation process, and contains ingredients such as polyphenols that are effective for the human body, and is a food with high nutritional value. Recently, polyphenols, hemicellulose, and pectin ingredients have immune functions. Studies have been shown that it has activation and anti-cancer activity, and when the rice bran is fermented, the total polyphenol content is markedly increased, and the antioxidant effect such as superoxide dismutase (SOD) activity becomes active.

The composition of rice bran varies depending on rice varieties and methods, but rice bran has been analyzed to contain 105% of moisture, 4826% of carbohydrates, 1743% of crude fat, 151% of crude protein, and 88% of ash, and more than 80% of fatty acids It has been shown to be unsaturated fatty acids such as oleic acid and linoleic acid (Choi et al, 2010). It also contains various nutrients such as vitamin A, B, B6, iron and phosphorus. Therefore, it has been found that rice bran is a by-product of Jeongbaekmi, but is a very good material for nutrition.

Rice bran is an important component that can promote fermentation by promoting the growth of microorganisms, and a large amount of GABA contained in itself is extracted to further increase the amount of GABA in the fermentation product. In the present invention, it can be used as a carbon source for microbial cell growth. After preparing a culture solution containing sugar nutrients for promoting microbial growth, using the sugar nutrient culture medium formed as described above, the microorganisms useful for fermentation of sugar are expanded and cultured in two stages, and the sugar nutrient culture solution is supplied to provide a multi-complex. After the microbial proliferation is promoted and activated to increase the activity rate and survival rate, and to produce a complex microbial active culture medium that realizes a complex synergistic effect exerting a strong force by combining different species, the content of GABA as a by-product of grain processing in the composite microbial culture medium The complex microbial active culture medium in this rich rice bran Thereby producing a high concentration of GABA promote fermentation extract which maximizes the absorption efficiency of the nutrients such as GABA, depending on the fermentation production process in which the fermentation mixture.

In particular, in the present invention, the gaba-enhanced fermentation extract injects a culture solution containing a separately prepared sugar nutrient into a mixed microorganism in order to promote microbial proliferation, and is sequentially cultured in two stages for proliferation according to the adaptability and immunity enhancement of the microorganism. By fermenting the expanded microbial active microbial culture to the rice bran, it is promoted by fermentation of the rice bran itself and lactic acid beef, and contains a rich amount of GABA to form a high-concentration gaba-enhanced rice bran fermentation extract that maximizes the absorption efficiency of nutrients. Among them, lactic acid bacteria and Bacillus bacteria, which have strong viability, are contained to help the suit action of the user who ingested the composition of the present invention.

In the present invention, the culture medium for promoting microbial growth containing the separately prepared sugar nutrient is 30% by weight sugar, 30% by weight glucose, 20% by weight potassium chloride, based on 100% by weight (%) of purified water heated to 50-60 ° C, Agitation heating mixing composition may be included, including 5% by weight of sodium hydrogen carbonate, 5% by weight of acetyl salicylic acid, and 10% by weight of citric acid.

In particular, the high concentration gaba-enhanced rice bran fermentation extract according to the present invention contains carbohydrates, proteins and lipids, which are active ingredients of rice, and is rich in its own antioxidants and is not toxic, as well as alcohol dehydrogenation, an important factor in alcohol detoxification. It increases the activity of enzymes (ADH) and aldehyde dehydrogenase (ALDH), lowers the concentration of acetaldehyde in the blood alcohol and liver, which are known to be the main causes of hangover, and relieves hangovers as well as gastric acid excessively secreted by alcohol It can also help relieve heartburn.

In addition, the hwangchil tree and plum are added to the main raw material consisting of fermented rice bran fermentation, which also helps in enhancing immunity and fatigue, and is a supplementary material that enhances antimicrobial function. It is a carotenoid-based antioxidant. As a natural product that performs phenol and flavonoids (Quercetin-QUERCETIN), it has an anti-cancer effect and selectively adds a gardenia extract or turmeric extract with a high content of dietary fiber to help intestinal movement activation. Will reinforce it further.

For the above-mentioned gardenia, which acts as a natural preservative, Donguibogam has written, "Properties are cold, tasteless, non-toxic, governs the heat of the small intestine and heart, is effective for gastritis, excretes urine and removes jaundice." Sedation and analgesic action It is known that crocin and crocetin in Eda Gardenia promote bile secretion, which promotes secretion and excretion of bile and suppresses bilirubin increase in blood, and thus exhibits a certain liver protective function.

In addition, among the seaweed fermented extracts adopted as the auxiliary material, brown seaweed with seaweed, which is known to have a strong anti-oxidation effect, is added to the extract of kelp and kelp, which is a polyphenol substance contained in persimmon, which is an antioxidant and anti-oxidant. It is known to have excellent hypertension, hypothrombosis and anti-cancer activity and stabilize the central nervous system by activating the gaba receptor with the polotanin component.

The kelp, which contains a large amount of gaba, lowers cholesterol levels and blood pressure, lowers blood sugar levels, and is used to treat diabetes, prevents thyroid disease, helps intestinal movement, eliminates constipation, discharges carcinogens, prevents colon cancer, and relieves hangovers And alginic acid and minerals contained in kelp are effective in removing constipation and feces by actively inducing peristalsis, and acidic polysaccharides among kelp ingredients prevent absorption of cholesterol and prevent arteriosclerosis. This is known.

In addition, as a herbal medicine for natural hangover, which is good for alcoholic liver disease, which is added to further relieve hangover and protect liver cells, licorice is used as a solubilizer for poorly soluble substances. In addition to the cinnamon, which protects the liver by acting on the cell membrane of the liver cells and protects the liver, the extract of medicinal herbs such as jujube and ginger is added in addition to the brown root that realizes the disintegrating effect by resolving thirst.

It is also rich in aspartic acid and citric acid, which improves liver function, eliminates fermentation odor, improves the taste and aroma of the fermentation composition of the present invention with fresh flavor and refreshing sweetness, improves functionality, and plums among the fruit extracts that improve consumer preference As a fruit of plum tree, its origin is China, used as food and medicine in the classic new farming of medical books, contains a large amount of minerals, relieves headaches, maintains blood in weak alkalinity, bleeding, tonic, interpolating, fatigue It smoothly recovers, prevents aging, and sterilizes, and contains citric acid, malic acid, and succinic acid as organic acids. Among them, it is rich in citric acid and decomposes lactic acid, a fatigue substance accumulated in the body, and excretes it from the human body. do.

The pear has a strong sweet taste and tastes good. It contains 90% of the digestive enzymes, so it has antipyretic effect, sore throat due to cold or tonsillitis in the recovery period of fever, and relieves thirst due to heat or drinking or hangover. And, it performs fatigue recovery function by aspartic acid.

Therefore, the present invention is to complement each other, without compromising physical properties, by adding 5% by weight, respectively, of the functionally enhanced extract having a harmonious weakness compared to the main raw material as a subsidiary material to the fermentation process and mixing them to easily share the ingredients. To further include as an active ingredient, various organic acids, sugars, vitamins, minerals, amino acids, unsaturated fatty acids, and dietary fiber are reinforced to improve bioavailability and physiological activity, effectively improve hangover and liver function, and have excellent taste and aroma. Various healthy ingredients can be easily and conveniently taken together in a comprehensive way, so that the liver and liver damaged before and after drinking can be quickly recovered by supplementing actions such as vitamin C and B destroyed by alcohol through the synergistic effect of each active ingredient and promoting metabolism by various nutrients. Fermentation weight of hwangchil tree It is possible to prepare a complex fermentation extract for improving hangover function and improving liver function by mixing and extracting fermented extract from each extract.

In addition, the complex fermentation extract for improving hangover and improving liver function of the present invention is effective in kneading the mixed raw materials and then formulating the formulation in a certain weight by a changer, pill-shaped tablets, tablets, and elliptical capsules. It is molded into various formulations that contain the efficacy of the active ingredient.

In addition, when the extract is prepared, the extract of the present invention may include itself or a pulverized product, an extract or a fraction thereof, and the composition ratio of each raw material may be added or subtracted within a normal range, and the same or similar medicinal chemistry may be added to the composition. It may contain one or more active ingredients exhibiting a function.

Example 1. Reduction of hangover and improvement of liver function by mixing hwangchil tree fermentation extract and fermented fermentation extract and preparation of complex fermented food extract

1-1. Preparation of Hwangchil Fermentation Extract

The hwangchil tree leaves and branches are finely chopped in a ratio of 1: 3 by weight, washed with functional water containing nano-bubbles having sterilization, antibacterial effect, anthelmintic effect, and cleaning effect to remove impurities and germs, and then with hot air drying. In contrast, the rapid drying process using far-infrared radiation energy, which increases the antioxidant activity by emitting wavelengths in the range of 2 to 14 μm, minimizes damage to the saponin component while fermenting hwangchil tree leaves and branches with the effect of far-infrared treatment to produce the saponin (ginsenoside) component. In the far-infrared sterilization drying device with sterilization and drying function to improve, it is dried at a temperature of 40-50 ℃ for 2 hours with a water content of 8-10%, finely cut the leaves and branches of the dried hwangchil tree, and then nutrients below -20 ℃ Freeze and dry using a freeze-drying method to minimize destruction, and pulverize in an air-flow grinder so that there is no frictional heat or destruction of nutrients It is divided into fine powders, and then it contains a cyclone that collects the powder, and classifies it into a double cyclone classifier that separates coarse powder from the powder collected by the cyclone, but repeats the pulverizing operation five times to classify it as nano-sized ultrafine powder ( Closed Circuit System) As a fermenting microorganism in the powdered hwangchil mixed raw material of hwangchil tree leaves and stems in which the cell wall is destroyed in the ultra-fine state of nano size of 20 μm or less by pulverization as a fermented microorganism, the liver has a weight of 5% by weight compared to the hwangchil mixed raw material The functional fermentation microorganism and the complex fermentation microorganism composed of yeast and Bacillus subtilis (Lactobacillus) strain and yeast that decompose the protein interact with the complex fermentation microorganism to overcome the limitations of microbial application, and the components are organically complementary to each other. 5, which promotes microbial activity promotion through combined synergistic effect The enzyme that promotes microbial activity, which contains an amount of Sanya herb enzyme or carbohydrate degrading enzyme, proteolytic enzyme, and lipolytic enzyme, emits far-infrared rays, and micro pores are formed to breathe to increase the activity of active ingredients during fermentation The mixture is mixed in a fermentation tank made of bio-ceramic material, and the antioxidant effect is enhanced by low temperature fermentation for 48 hours so that the active ingredient is not destroyed in the enzyme fermentation tank at a temperature of 20 ° C to 40 ° C. A hwangchil tree fermented extract in the form of a fine powder of a green onion enzyme fermentation was obtained to enhance and increase the extraction efficiency of the total polyphenol as an active ingredient.

1-2.Preparation of fermented extracts every year

After screening for every 30 minutes in purified water after selecting Maesongi, it is repeatedly washed three times with flowing functional water containing nano bubbles having sterilization, antimicrobial, anthelmintic and cleaning effects to remove impurities and germs with salt discharge, and then 2 to 14 It is a quick drying process using far-infrared radiation energy that emits a wavelength in the range of µm and increases antioxidant activity. It is frozen and dried by freeze-drying method to minimize the destruction of nutrients below -20 ℃, and it is pulverized into a fine powder by pulverizing it in an air-flow grinder so that there is no frictional heat or destruction of nutrients. It is classified into a double cyclone classifier that separates coarse powder from the collected powder, but crushes it five times. The closed circuit system pulverized repeatedly to classify the nano-sized fine powder into ultra-fine powder in a nano-sized ultra-fine particle size of 20 µm or less to give the fine powder-like essence without viscous texture to the powdered lysine 5 weight compared to the raw material % Of Bacillus subtilis, Lactobacillus strain and yeast and fermentation microorganisms and natural glutamic acid derived from falconis interact with the complex fermentation microorganisms that convert to GABA (gamma-ammino butyricacid) To promote the activity of microorganisms, 5% by weight of wild grass or carbohydrate-degrading enzyme, protease, and fat-degrading enzyme containing complex enzyme for promoting microbial activity in a bio-ceramic (Bio-Ceramic) fermentation tank, respectively Mix and do not destroy the active ingredient in the enzyme fermentation tank at a temperature of 20 ℃ to 40 ℃ Off 48 hours to obtain a low-temperature fermentation maesaengyi fermentation extract the antioxidant effect is enhanced.

1-3.Production of Gaba-enhanced rice bran fermentation extract

A. Preparation of useful microbial active culture

30% by weight sugar, 30% by weight of glucose, 20% by weight of potassium chloride, 5% by weight of sodium hydrogen carbonate, 5% by weight of acetyl salicylic acid, citric acid with respect to 100 parts by weight (%) of purified water heated to 50-60 ° C It was stirred and heated to contain 10% by weight to obtain a culture solution containing sugar nutrients for promoting microbial growth.

B. Preparation of rice bran fermentation extract

The culture solution extracted in the step (a) is a rice bran fermentation strain having excellent GABA production ability, and is added to a complex useful microorganism composed of lactic acid bacteria, yeast, and archaea to produce a temperature of 20-40 ° C in a fermentation tank made of bio-ceramic material. Under the conditions, the sequential expansion and propagation culture was performed in two stages for 30-50 hours, and the microorganisms were multiplied as much as possible, and low temperature fermentation was performed by the action of the complex fermentation microorganisms to enhance GABA to form a gaba enhanced rice bran fermentation extract with high alcohol degrading activity.

1-4.Complex fermentation extract of Hwangchil fermentation extract and Maesongi fermentation extract and Gaba-enhanced rice bran fermentation extract

The fermentation extract of Hwangchil obtained in steps 1-2. And 1-2. And 1-3. And the fermentation extract and gaba-enhanced rice bran fermentation extract obtained in the process are complementary to each other at the same ratio (weight ratio) of 1: 1. It is a mixed fermentation composition composed of fermented extract and fermented extract of rice bran as an active ingredient in the fermented extract of hwangchil tree leaves and branches for the purpose of resolving hangover and improving liver function by mixing the mixture to work. A complex fermentation extract was obtained to relieve hangover and to improve liver function.

1-5. Reduction of complex functional hangover and improvement of liver function Preparation of complex fermented extract

As a supplement to the functional enhancement component for supplementing the functionality of the complex functional food fermentation extract extracted in step 1-4. As a carotenoid-based antioxidant, it is a yellow-based natural pigment, and as a natural product that performs antibacterial and bactericidal action against bacteria, phenol and Flavonoids (Quercetin-QUERCETIN) contain anti-cancer effects and high content of dietary fiber that helps intestinal movement activation. To further enhance the function,

In addition to its excellent antioxidant effect, it is rich in amino acids of vegetable fiber, taurine, iron, and calcium, which is effective in removing hangovers and enhances the content of gaba (gamma-aminobutyl acid), further increasing the yield of GABA and producing a large amount of natural GABA. Through the high alcohol metabolism promoting effect according to the content, it activates the gaba receptor to realize the effect on the hangover after drinking, and adds 5% by weight of persimmon extract and kelp extract as a seaweed rich in polyphenols.

To supplement hangover and hepatocellular protective function, a herbal extract for liquor, jujube, cinnamon, ginger, Angelica, and brown root used as a solubilizer for poorly soluble substances as a natural hangover remedy is also 5 wt% Add more,

Fruit extract consisting of pears and plums, which are rich in aspartic acid and citric acid, which improve liver function, are added as 5% by weight, respectively, as a supplement to each of the complex functional food fermentation extracts and mixed, so that the complex functional hangover can be easily shared between ingredients And improvement of liver function By forming with complex fermented extract, it contains organic acids and gaba produced by useful microorganisms such as lactic acid bacteria, as well as a large amount of bioactive substances such as gabara, which improves bioavailability and physiological activity, hangover and liver function Effectively, various health ingredients with excellent taste and aroma can be easily and comprehensively taken together to improve, and the synergistic effect of each active ingredient can quickly recover the damaged liver and liver before and after drinking. Fermentation A complex fermentation extract was prepared to relieve hangover and improve liver function with the extract mixed.

2. Manufacturing Example: Preparation of pills for relieving hangover

Eliminate hangover and improve liver function prepared in step 1 as described above, knead with a complex fermentation extract, and then replace it in the form of 5 mm-sized granules with a changer to remove unpleasant odors and have an effect on weak digestives. Functional pills containing a complex fermentation extract to improve hangover and improve liver function of the present invention in a formulation were obtained.

(Experimental Example 1) Evaluation of the effect on alcohol concentration in the body

In order to investigate the hangover-relieving efficacy of the present invention prepared through the above examples, clinical experiments were conducted on the alcohol concentration in the body.

In order to reduce the significant difference, the test subjects were 10 healthy males of the same age, 40 years old, and were given the same amount of drinking (1 bottle of soju, 360 ml, 19.5% Alc) for men with similar doses.

    division              Control             Experimental group Alcoholic beverages
Immediate alcohol concentration (mg / L) Alcohol 30 minutes
After alcohol concentration (mg / L) Alcoholic beverages
Immediate alcohol concentration (mg / L) Alcohol 30 minutes
After alcohol concentration (mg / L) One 0.07 0.11 0.08 0.05 2 0.08 0.16 0.07 0.05 3 0.25 0.33 0.20 0.10 4 0.45 0.60 0.40 0.25 5 0.07 0.12 0.08 0.05 6 0.07 0.15 0.08 0.06 7 0.35 0.45 0.50 0.20 8 0.30 0.40 0.40 0.30 9 0.08 0.20 0.10 0.05 10 0.06 0.15 0.10 0.06

    * Scoring criteria: 1. Very bad 2. Bad 3. Normal 4. Good 5. Very good

    Control group: Alcoholic (mg / L) measured with a breathalyzer after 30 minutes without drinking anything, and not taking any recovery.

    Experimental group: As the same test subjects, after drinking 2 weeks after the control experiment, taking the complex extract to relieve hangover and improve liver function of the present invention after drinking and increasing the alcohol concentration with a breathalyzer.

Measure by group

    As shown in the above table, as a result of the panel test, the alcohol concentration of the experimental group was significantly lower than that of the control group. After 30 minutes of alcohol consumption, the alcohol concentration was significantly increased immediately after drinking alcohol, while the alcohol concentration was higher after drinking. In the case of one experimental group in which the composition of the Example was ingested, it was confirmed that the alcohol concentration was significantly reduced.

(Experimental Example 2)-Effect of eliminating hangover symptoms

A clinical experiment was conducted to investigate the hangover-relieving efficacy of the present invention prepared through the above-described examples.

In order to reduce the significant difference, the test subjects were 10 healthy males (5 control groups, 5 control groups), 40 years old, who were the same age, and in order to improve the accuracy of the experiment, they experienced drinking from 10 days before the experiment. Not allowed. In addition, in order to equalize the degree of intake, the same drinking amount (1 bottle of shochu, 360 ml, 19.5% of Alc) was consumed over the same time (2 hours) for men with similar amounts of alcohol, and was taken 5 hours after drinking. Was evaluated. The hangover relieving effect evaluation items are five evaluation items such as headache, fast-drying, thirst, tiredness, and vomiting. The results were averaged by scoring using a 5-point scale scoring method.

division headache Inner feeling thirst Tired Vomiting Control 1.8 1.0 1.5 2.0 2.5 Experimental group 4.2 4.0 3.8 4.0 4.2

     * Scoring criteria: 1. Very bad 2. Bad 3. Moderate 4. Good 5. Very good Control: Drinking only alcohol and not taking any recovery

     Experimental group: a group taking a complex extract to relieve hangover and improve liver function of the present invention

     As a result of the experiment, the group that took the complex extract to relieve hangover and improve liver function prepared by the method of the present invention has a satisfactory and significant effect on improving the hangover relief phenomenon due to alcohol intake compared to the group not taking the extract of the present invention. It turned out.

That is, the effect of the experimental product of the present invention on the hangover of alcohol showed a great effect on the hangover symptom index of the test subject. In almost all query items, the test product showed better improvement than the control product, and it was confirmed that the effect was clear in statistical evaluation by detail item.

The present invention described above is not limited to the above-described embodiments because various substitutions and changes can be made within the scope of the technical spirit of the present invention to those skilled in the art to which the present invention pertains. .

Claims (4)

In the method of manufacturing a complex fermentation extract to relieve hangover and improve liver function,
Contains a large amount of various inorganic salts such as iron, potassium, and iodine, and vitamins A and C in the fermented extract of hwangchil tree leaves and branches, which has revealed various physiological activities such as relieving hangover, restoring fatigue, protecting hepatocytes, antioxidant activity, and enhancing immunity. Because it has a hangover relieving effect, gastric ulcer or duodenal ulcer prevention and sedation, cholesterol lowering effect, children's growth promoting action and constipation treatment efficacy, each of them has a fermented extract mixed with microorganisms through two-step sequential two-stage fermentation Fermentation increased by the fermentation process as the fermentation extract of hwangchil, maeseongi and rice bran is added in the same amount ratio by adding fermented extract of rice bran with high alcohol-degrading enzyme activity by low-temperature fermentation with the propagated useful microorganism culture medium. Hwangchil fermentation extract and egg to relieve hangover to help break down acetaldehyde with efficiency High concentration of gaba enhanced complex function food fermentation extract that is effective in relieving hangover through synergistic effect through interaction through a high alcohol metabolism promoting effect by containing a large amount of natural GABA in the efficacy effect of fermentation extract to help decompose the alcohol Gaba-promoting complex functional food mixed with the main raw material, functional enhancement component for supplementing functionality to the fermented extract, a natural product that performs antibacterial and sterilizing functions as a subsidiary material, a gardenia extract or turmeric extract containing a large amount of phenol and flavonoids (Quercetin-QUERCETIN) To selectively enhance the antioxidant function,
In addition to its excellent antioxidant effect, it is rich in amino acids of vegetable fiber, taurine, iron, and calcium, which is effective in removing hangovers and enhances the content of gaba (gamma-aminobutyl acid), further increasing the yield of GABA and producing a large amount of natural GABA. Through the high alcohol metabolism promoting action according to the content, it activates the Gaba receptor to realize the effect on the hangover after drinking and selectively adds persimmon extract and kelp extract as a seaweed rich in polyphenols.
In addition, in order to further strengthen the hangover-relieving and hepatocellular protective function, an herbal extract made of licorice, jujube, cinnamon, ginger, Angelica and brown root, which is used as a solubilizer for poorly soluble substances, is also added.
Fruit extract consisting of pears and plums, which are rich in aspartic acid and citric acid, which improve liver function, are added as 5% by weight of each as a secondary ingredient compared to the gaba-enhancing complex functional food fermentation extract as the main raw material and mixed to form easily shared between ingredients. Method for manufacturing a complex fermentation extract that improves liver function and improves hangover by mixing the composition of Hwangchil tree fermentation extract and Maesongi fermentation extract According to claim 1,
The hwangchil fermentation extract is finely chopped hwangchil tree leaves and branches in a ratio of 1: 3 and washed with functional water containing nanobubbles having antiseptic, antibacterial, antiparasitic, and cleaning effects to remove impurities and germs. Unlike the next hot air drying, the rapid drying process using far-infrared radiation energy, which increases the antioxidant activity by emitting wavelengths in the range of 2 to 14㎛, minimizes the damage to the saponin component while fermenting saponin leaves and branches with the effect of far-infrared treatment. (ginsenoside) In order to enhance the ingredients, the far-infrared sterilization drying device with sterilization and drying functions was dried at a temperature of 40-50 ° C for 2 hours to 8-10% of moisture content, and then finely cut the hwangchil tree leaves and branches from which moisture was removed- Freeze and dry with freeze-drying method to minimize nutrient destruction under 20 ℃ and prevent friction heat or nutrient destruction. Nano-sized ultra fine powder by repeating 5 times by pulverizing and pulverizing operation five times by pulverizing in a pulverizer into a double cyclone classifier that separates the coarse powder from the powder collected by the cyclone. As a fermenting microorganism, the powdered hwangchil mixed raw materials of hwangchil tree leaves and stems, which have cell walls destroyed in the ultra-fine state of nano size of 20 μm or less by pulverized closed circuit system pulverization as a fermenting microorganism, The effect of improving liver function by 5% by weight and the complex fermenting microorganism consisting of Bacillus subtilis, Lactobacillus strain and yeast, and the complex fermenting microorganism interacting with the complex fermenting microorganism to overcome the limitations of application of microorganisms Microorganisms with organic synergistically combined complex synergy When fermentation by fertilizing the micro-pores by breathing far-infrared rays, the complex enzyme for promoting microbial activity, which contains 5% by weight of a wild grass plant enzyme or carbohydrate degrading enzyme, proteolytic enzyme, and fat degrading enzyme, which promotes sex promotion It is mixed in a fermentation tank made of bio-ceramic material that increases the activity of the active ingredient, and the antioxidant effect is enhanced by low temperature fermentation for 48 hours so that the active ingredient is not destroyed in the enzyme fermentation tank at a temperature of 20 ° C to 40 ° C. Hwangchil tree fermentation extract, which is characterized by forming hwangchil tree fermentation extract in the form of a fine powder of green onion enzyme fermentation, which enhances the pharmacological activity of hwangchil tree and increases the extraction efficiency of the total polyphenol as an active ingredient. Method for preparing a complex fermented extract to relieve hangover and improve liver function According to claim 1,
The fermented extract of Maesi-yi is selected by soaking it in distilled water for 30 minutes or more, and washed three times with flowing functional water containing nano bubbles having sterilization, antibacterial, anti-helminth and cleaning effects to remove impurities and germs along with salt discharge. After removal, it is a quick drying process using far-infrared radiation energy that increases the antioxidant activity by emitting wavelengths in the range of 2 to 14 μm. The removed snails are frozen and dried using a freeze-drying method to minimize nutrient destruction at -20 ℃ or less, and pulverized into a fine powder by pulverizing them in an air-flow grinder so that there is no frictional heat or nutrient destruction, and then collecting the powder. Includes and when classifying with a double cyclone classifier to separate the crude powder from the powder collected by the cyclone The pulverization operation is repeated five times to classify the nano-sized fine powder into a closed-circuit system pulverization to finely powder into a nano-sized nano-sized ultra-fine particle having a size of 20 μm or less. The powdered broth converts the natural glutamic acid derived from the complex fermented microorganism consisting of Bacillus subtilis, Lactobacillus strains and yeast and 5% by weight compared to the raw material into GABA (gamma-ammino butyricacid) Bio-ceramic (Bio-Ceramic) is a complex enzyme for promoting microbial activity, which contains 5% by weight of Sanya herb enzyme or carbohydrate degrading enzyme, proteolytic enzyme, and lipolytic enzyme, which interacts with the complex fermenting microorganism to promote microbial activity. ) Materials are mixed in a fermentation tank of material, and in an enzyme fermentation tank at a temperature of 20 ° C to 40 ° C. Fermentation of hwangchil tree fermented extract, which is characterized by that the fermented extract with enhanced antioxidant effect is formed by fermentation at low temperature for 48 hours so as not to destroy the active ingredient, and hangover relief and liver function improvement complex fermentation extract with mixed composition Way According to claim 1,
The gaba enhanced rice bran fermentation extract is 30% by weight sugar, 30% by weight of glucose, 20% by weight of potassium chloride, 5% by weight of sodium hydrogen carbonate, 5% by weight of sodium bicarbonate, acetylsalicylic acid (acetyl Salicylic acid) 5% by weight, 10% by weight of citric acid, a culture medium formed by stirring and heating is a rice bran fermentation strain with excellent ability to produce GABA.It is a bio-ceramic material by adding a complex useful microorganism consisting of lactic acid bacteria, yeast, and archaea. In the fermentation tank of 20-40 ° C, in 30-50 hours, two-step sequential expansion and cultivation are performed to grow the microorganism as much as possible. Hwangchil tree fermentation extract, characterized in that it forms an enhanced rice bran fermentation extract, and hangover remediation and liver function development in which fermentation extract is mixed Method of manufacturing a composite fermented extract