KR101394358B1 - Health composition relieving alcohol hangover - Google Patents

Abstract

The present invention relates to a composition for relieving hangover, and food or a pharmaceutical product containing the same. The composition for relieving hangover includes dried gingers, a mixed extract of dried tangerine peel and cinnamon, shiitake mycelium culture liquid, a green tea extract, and indigestible maltodextrin. By a synergy effect of the materials included, the composition for relieving hangover is highly effective for relieving hangover, and can significantly reduce a blood alcohol level after drinking. Especially, the composition for relieving hangover is generally and highly effective in adults without a difference between individuals.

Description

{Health composition relieving alcohol hangover}

The present invention relates to a hangover resolution composition for reducing alcohol concentration and for relieving hangover after drinking, and a hangover relieving food or medicament containing the same.

Alcohol has the advantage of providing a relatively high calorie from the nutritional point of view, helping blood circulation and digestion, and increasing blood HDL-cholesterol to prevent cardiovascular disease. However, when consumed excessively, Alcohol intoxication due to some people taking too much alcohol is emerging as a social problem because it can cause malnutrition and impair liver function and even damage brain tissue.

When excessive intake of alcohol is inevitable, the symptoms of hangover are caused by the poisoning of ethanol or acetaldehyde accumulated in the hepatocyte. If these substances accumulate in hepatocytes for a long period of time, if the toxicity persists, fatigue, Abdominal bloating, and vomiting. Normal metabolic processes of ethyl alcohol are absorbed from the stomach or small intestine when ethyl alcohol enters the body, and it is transferred into the blood vessels and transferred to the liver. The hepatocytes have an alcohol dehydrogenase, which oxidizes the alcohol to acetaldehyde. The acetaldehyde is decomposed into acetic acid by the acetaldehyde dehydrogenase in hepatocytes, which is then transferred to muscle or fat tissue of the whole body and finally decomposed into carbon dioxide and water will be. The acetaldehyde enzyme also has type II, which initiates oxidation even when acetaldehyde is low in concentration, and type I, which does not act if acetaldehyde is not used at high concentrations. However, because Asian people generally lack or lack II-type acetaldehyde The oxidation of acetaldehyde is slow, and thus the normal metabolism is inhibited by the toxic action of acetaldehyde or ethyl alcohol which is not oxidized, and various hangover phenomenon is felt.

Therefore, many studies have been conducted on drugs to solve the hangover phenomenon after drinking, and many of them have already been introduced, and most of them are substances which decrease the toxicity of alcohol in the body through the activity of alcoholase or acetaldehydease And products based on these technologies. However, whether these drugs reduce blood alcohol levels has been largely not scientifically tested or shown to be insignificant. In addition, since the effect of reducing the enzyme activity and toxicity in vivo is large due to the large individual difference, the effect is not only limited but also has little effect.

Among them, there are the Condition (Cheil Jedang), Aspa (Target), Solpyo Business (Korean shipbreaking), Daehan 808 (Grammy) and Reception (Future Bio) It is only a fraction of the clinical trials that have been conducted, and even some of them have been effective in taking nearly five times the normal dose. In addition, there is a drug Mildronate, which has been used in Russia for a long time to treat alcoholics, which makes it feel less drunk to drink and has fewer headaches after alcohol breakdown, There is no.

Therefore, there is a growing need for an agent that can relieve hangover symptoms after alcohol consumption, dramatically reduce blood alcohol concentration, and exhibit efficacy without individual differences.

KR 10-2002-0092562 A KR 10-2000-0066777 A KR 10-2011-0129673 A KR 10-2006-0060427 A KR 10-2013-0069422 A KR 10-2011-0022883 A

Accordingly, a problem to be solved by the present invention is to provide a composition for relieving hangover which can exert an excellent effect on hangover resolution, remarkably reduce blood alcohol concentration after drinking, and exert an excellent effect on adults on average, without individual differences .

In order to solve the above problems, the present invention provides a composition for relieving hangover comprising a mixed extract of health, a dermis and a broiler, a cultured mycelium, a green tea extract, and an indigestible maltodextrin.

Health ( Zingiberis Rhizoma) says the rhizomes of ginger (Zingiber officinals Roscoe) of ginger (Zingiberaceae). Because it has a hot and spicy nature, it warms the inside of the body and sends out the chill in the body and works to bring back warm mangy. Therefore, it is good to use health for diarrhea caused by cheating, and it is also effective for symptom of vomiting when holding chewy food. In addition, cold coughing and coughing symptoms or stomach symptoms are also cured.

The dermis is ash tree ( Fraxinus rhynchophylla Hance ) or the stem of a stem. It promotes digestion, stimulates gut mite function, has the effect of raising blood pressure, has the effect of drying down heat and drying out, and is used for dysentery, dahlia, dahlia, eye congestion, pain, seawater and asthma. do.

The broiler was a broiler tree ( Camnamomum cassia Blume is a bark of meat. It is spicy, sweet and has a good temperament. There is a tendency to increase the number of patients who have diarrhea due to diarrhea, diarrhea, vomiting, menstrual irregularities, menstrual cramps, postpartum hemorrhagic abdominal pain, diarrhea, Skin ulcers, and limb paralysis.

In the present invention, it is preferable that the mixed extract of health, dermis and broiler is mixed in a weight ratio of 1: 1.5 - 3: 0.5 - 2 on a dry basis. More preferably, they can be mixed in a weight ratio of 1: 2: 1 on a dry matter basis. In the case of mixing below the lower limit of the weight ratio, the physiological activity of each component is decreased. When the mixing ratio exceeds the upper limit of the weight ratio, the synergistic effect between the herbal medicines is not large but economically inefficient.

The health, dermis and broiler mixed extracts can be separately extracted by conventional methods, mixed with the extracts, or mixed with health, dermis and broiler chickens, and then extracted at once, and if necessary, it can be concentrated and dried to be powdered . In the case of a liquid phase, it is preferable to use a sugar of at least 4 brix.

Extraction is carried out according to a conventional method known in the art, and water, an organic solvent or a mixed solvent thereof can be used as a solvent. The extraction method is not limited thereto. For example, the extraction may be carried out using a cooler, an ultrasonic wave, . Preferably, the extract may be obtained by extracting the active ingredient by cooling or warming, filtering, and then concentrating the filtrate by concentration under reduced pressure.

The combined extracts of health, dermis and broiler chickens may comprise, preferably, from 0.2 to 30% by weight, more preferably from 1 to 10% by weight, and most preferably from 1 to 3% by weight . If it is contained in an amount of less than 0.2% by weight based on the total weight of the composition, sufficient hangover resolution effect is not exhibited. If it exceeds 30% by weight, there is no significant effect on increase of hangover effect.

Shiitake mushroom ( Lentinula Edodes have a substance called eridademine, which is said to lower the blood cholesterol level. In addition, since it also acts to lower blood pressure, it is useful for prevention of hypertension and arteriosclerosis. Vitamin B1 and B2 are also abundant in shiitake mushrooms. The richness of shiitake mushrooms is used as a component of nucleic acid-based seasoning by guanylate.

The cultivated mycelium of mushrooms may be obtained by inoculating mushroom mycelia into a conventional mushroom culture medium and culturing it for a few days, but commercially available mushroom cultures can also be obtained. In the case of a liquid phase, it is preferable to use a sugar of at least 3.5 brix.

The mushroom mycelial culture may contain 1 to 50 wt%, more preferably 5 to 30 wt%, and most preferably 5 to 15 wt% of the total weight of the composition. If it is contained in an amount of less than 1% by weight based on the total weight of the composition, sufficient hangover resolution effect is not exhibited. If it exceeds 50% by weight, there is no significant effect on increase of hangover effect and the commercial taste is deteriorated due to unique flavor.

Green tea is a tea and belongs to the evergreen tea ( Camellia the leaves of sinensis) as a raw material by means of the enzyme was inactivated by heating, without going through the fermentation process. It contains catechin and polyphenol and is effective for vascular diseases such as arteriosclerosis.

Green tea extracts may be prepared according to conventional methods known in the art or may be obtained commercially via distribution channels. Extraction is carried out according to a conventional method known in the art, and water, an organic solvent or a mixed solvent thereof can be used as a solvent. The extraction method is not limited thereto. For example, the extraction may be carried out using a cooler, an ultrasonic wave, . Preferably, the extract may be obtained by extracting the active ingredient by cooling or warming, filtering, and then concentrating the filtrate by concentration under reduced pressure. For improving the solubility and the like, suitable excipients such as cyclodextrin can be used.

The green tea extract may contain 0.001 - 10 wt%, more preferably 0.005 - 5 wt%, and most preferably 0.01 - 0.05 wt% of the total weight of the composition. If it is contained in an amount of less than 0.001% by weight based on the total weight of the composition, sufficient hangover resolution effect is not exhibited. If it is contained in an amount exceeding 10% by weight, there is no significant effect on increase in hangover resolution.

Ovarian maltodextrin was recognized as a function of smooth bowel movements, inhibition of postprandial hyperglycemia, and improvement of serum triglyceride. Edible ovarian maltodextrin is obtained by heat-treating cornstarch starch to α-amylase (α-amylase, Bacillus subtilis or Bacillus licheniformis ) and amyloglucosidase (derived from Aspergillus niger ), and the fraction of the indigestible component is fractionated to be suitable for edible use. When it is not a liquid phase, the content of the dietary fiber solid content should be 85% or more, but in the case of a liquid phase, it is preferably 58% or more.

The indigestible maltodextrin may be contained in an amount of preferably 0.5 to 30% by weight, more preferably 1 to 20% by weight, and most preferably 3 to 13% by weight based on the total weight of the total composition. If it is contained in an amount of less than 0.5% by weight based on the total weight of the composition, sufficient hangover resolution effect is not exhibited. If it exceeds 30% by weight, there is no significant effect on increase in hangover resolution, but it has a bad effect on physical properties and is uneconomical.

The composition according to the present invention may further comprise at least one extract selected from the group consisting of garlic extract, bamboo shoot extract, rhizome extract or hodgkin's extract.

The gallbladder is called Pueraria lobata (Willd.) Ohwi: Pueraria thomsonii Benth .: 葛 根) and flower buds ( Pueraria thomsonii Benth .

The Poria cocos ) is a mushroom and mushroom.

The above dried ( Trapa japonica ) refers to the annual plant of the dicotyledonous plant deciduous group plating.

Hovenia dulcis THUNB. Refers to a deciduous broad-leaved arboreous tree of the dicotyledonous gabbro tree.

In the present invention, when two or more herbal medicine extracts are further contained in the herbal medicine, the mixed herbal extracts can be extracted by conventional methods, mixed with the herbal extracts or mixed with herbal medicines, It may be concentrated and dried to be powdered.

Extraction is carried out according to a conventional method known in the art, and water, an organic solvent or a mixed solvent thereof can be used as a solvent. The extraction method is not limited thereto. For example, the extraction may be carried out using a cooler, an ultrasonic wave, , Pressure extraction and the like can be used. Preferably, the extract can be obtained by pressure extraction.

Preferably, the garlic extract may be 0.001 - 1 wt%, the bamboo extract may be 0.001 - 1 wt%, the spinach extract may be 0.005 - 1 wt%, or the horny extract may be 0.001 - 1 wt%, based on the total weight of the whole composition. If it is contained in an amount exceeding each weight%, it affects the entire product due to the flavor peculiar to each herbal medicine, and if it contains less than each% by weight, the effect inherent in each herb medicine can not be sufficiently exhibited.

The composition for relieving hangover according to the present invention can be used for various purposes, and can be used, for example, as food (including health food), medicine and the like.

The composition for relieving hangover according to the present invention may be formulated by a method known in the art, and may be formulated in admixture with excipients, carriers and the like commonly used according to the specific use of the composition. For example, they may be formulated as a solution such as a drink, a syrup, a capsule, a thickener, a tablet, a capsule, a powder, a granule, a ring and the like, and they may be administered orally or parenterally. It can be administered before and / or after drinking alcohol.

The composition for dissolving hangover according to the present invention can be dosed once by a person skilled in the art according to the degree of absorption of the active ingredient, the excretion rate, the age and weight of the subject, the sex and the condition and the like.

The composition according to the present invention has an excellent effect for eliminating hangovers, and can remarkably reduce blood alcohol concentration after drinking, and can exert an excellent effect on adults on average without individual differences.

Hereinafter, in order to facilitate the understanding of the present invention, experimental examples and the like will be described in detail. However, the experimental examples according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following experimental examples. Experimental examples of the present invention are provided to enable those skilled in the art to more fully understand the present invention.

[ Experimental Example  1 - 17]

The cultured mycelium of supernatant was purchased from HK Biotech, and the product of 3.5 brix or more was used as a liquid product. For the production of a mixed extract of health, dermis and broiler (hereinafter referred to as "mixed extract A"), the raw materials corresponding to the standards and specifications suitable for food production were inspected, and 250g of health, 500g of dermis, Respectively. After washing the raw materials, the weighed raw materials and 7 kg of water were put into a tank and extracted at 85 to 100 ° C for 1 to 6 hours. Filtered, filtered, and concentrated to a sugar content of 4 Bx. The concentrate was sterilized at 65 to 95 ° C for 5 to 30 minutes.

The garlic extract was weighed and weighed 100 g of the raw material, added with 8 kg of water, and then pressurized and extracted at 95 ° C for 4 hours. After the extraction, the mixture was filtered using a microfilter, concentrated under reduced pressure to give 4brix, and then heated and sterilized at 90 ° C for 20 minutes to prepare a concentrate.

After extracting 90 g of raw material, 8 kg of water was added and the mixture was pressure-extracted at 95 ° C. for 4 hours. After extraction, the mixture was filtered using a microfilter, concentrated under reduced pressure of 3.6 brix, and then heated and sterilized at 90 ° C for 20 minutes to prepare a concentrate.

The indigestible maltodextrin was 2L of fiber sol of Matsudani Co., Ltd. Green tea extract was purchased from Bio Land Co., Ltd. The extracts of Bombyx mori were used in horseshoe crab, and the concentrate of Hovenia dulcis was purchased from Samyung food.

The mixture of the above mycelium cultures, the mixed extract A, green tea extract, indigestible maltodextrin, garlic, bamboo shoot, dried bean curd and horny bean were mixed according to the content ratio (unit: wt%) shown in Table 1 below.

Cultured mycelium Mixed extract A Green tea extract Indigestible maltodextrin Garlic extract Bamboo extract Acorn extract Hounsu extract Purified water Experimental Example 1 60 - - - - - - - Up to 100 Experimental Example 2 - 40 - - - - - - Up to 100 Experimental Example 3 - - 20 - - - - - Up to 100 Experimental Example 4 5 5.0 - - - - - - Up to 100 Experimental Example 5 10 2.0 - - - - - - Up to 100 Experimental Example 6 5 2.0 0.01 - - - - - Up to 100 Experimental Example 7 10 2.0 0.005 - - - - - Up to 100 Experimental Example 8 10 2.0 0.01 - - - - - Up to 100 Experimental Example 9 10 2.0 0.01 0.1 - - - - Up to 100 Experimental Example 10 10 2.0 0.01 40 Up to 100 Experimental Example 11 10 2.0 0.01 5 - - - - Up to 100 Experimental Example 12 15 3.0 0.05 10 Up to 100 Experimental Example 13 10 2.0 0.01 5 0.01 - - - Up to 100 Experimental Example 14 10 2.0 0.01 5 - 0.009 - - Up to 100 Experimental Example 15 10 2.0 0.01 5 - - 0.05 - Up to 100 Experimental Example 16 10 2.0 0.01 5 - - - 0.1 Up to 100 Experimental Example 17 10 2.0 0.01 5 - - 0.05 0.1 Up to 100

[ Test Example  1. Measurement of alcohololytic enzyme activity]

In order to measure the activity of the alcoholase (ADH) in Experimental Examples 1-17, the test was conducted using a commercially available kit.

Samples to be evaluated are diluted in assay buffer at appropriate magnification and placed in a 96-well plate in 50 ul increments. Assay buffer 82uL, developer 8uL, and 10uL of isopropanol were added to each well of the dilution buffer, and incubated at 37 ° C for 3 minutes. Absorbance was measured at 450 nm (A0) . After incubation for another 30 minutes, the absorbance was measured (A1), and then the alcohololytic enzyme activity was determined by the formula given in the kit. When the absorbance of the solvent control is taken as 1, the relative absorbances of the samples are shown in Table 2.

menstruum
Control group Experimental Example 1 Experimental Example 2 Experimental Example 3 Experimental Example 4 Experimental Example 5 Experimental Example 6 ADH activity One 2.0 1.83 1.32 2.36 2.53 2.55 menstruum
Control group Experimental Example 7 Experimental Example 8 Experimental Example 9 Experimental Example 10 Experimental Example 11 Experimental Example 12 ADH activity One 3.03 3.11 3.12 3.15 3.25 3.30 menstruum
Control group Experimental Example 13 Experimental Example 14 Experimental Example 15 Experimental Example 16 Experimental Example 17 ADH activity One 3.24 3.20 3.25 3.26 3.32

(The larger the value, the better the effect)

As can be seen from the above Table 2, it was found that when the cultured mycelium, mixed extract A, green tea extract, and indigestible maltodextrin were all included, the activity of alcoholase was excellent. In addition to the above four components, , Dried or horned, was found to show equivalent alcohololytic enzyme activity.

[ Test Example  2. Evaluation of alcohol decomposition effect]

In order to confirm the alcohol decomposing effect of the present invention with Experimental Example 11, Experimental Example 11 was administered to a test animal together with alcohol, and then the blood alcohol concentration and acetaldehyde concentration after 1, 3 and 5 hours were measured, The alcohol degradation effect was evaluated.

Six-week old SD rats were administered 3 mL of alcohol per kg of body weight, and the test product was administered twice at 30 minutes before and after alcohol administration. Blood alcohol concentration and acetaldehyde concentration after 1, 3, and 5 hours of alcohol administration were measured. The results are shown in Tables 3 and 4.

Changes in Blood Alcohol Concentration over Time (% Alcohol) 1hr 3hr 5hr Control (drinking water) 0.03 0.032 0.025 Commercially available products 0.025 0.023 0.02 Experimental Example 11 0.018 0.015 0.009

Changes in blood acetaldehyde concentration over time (mg / L) 1hr 3hr 5hr Control (drinking water) 8.5 6.5 5.2 Commercially available products 6.0 5.4 4.5 Experimental Example 11 5.1 4.8 3.1

As can be seen from Tables 3 and 4, it was confirmed that the concentration of alcohol and acetaldehyde was significantly decreased with the lapse of time in Experimental Example 11 administration group. In particular, it was found that the rate of concentration decrease over time was higher than that of commercial products as well as the control group.

[ Test Example  3. Estimation of hangover effect on ingestion]

To evaluate the efficacy of hangover in the intake of Experimental Example 11, hangover efficacy was evaluated in 30 healthy male adults.

The subjects were asked to drink soju of 1.3g alcohol / kg body weight per kg of body weight and then to take the test drinks before and after the alcohol consumption and to measure the amount of alcohol by using a drinking meter. One week later, the control drink (bottled water) was drunk and tested by the same method and compared with the test drinks.

Change in aerobic alcohol concentration over time (%) 1hr 3hr 5hr Contrast beverage (bottled water) 0.112 0.085 0.067 Experimental Example 11 0.095 0.068 0.050 Difference between groups ( P value) 0.0169 0.0122 0.0070

As a result, it was confirmed that the alcohol concentration decreased rapidly with the lapse of time when Experimental Example 11 was ingested, and it was confirmed that, despite the individual difference in the in vivo enzyme activity and toxicity reduction effect, it exerts excellent hangover resolution efficacy .

[ Product example  One. Hangover drink Manufacturing example ]

A beverage was prepared in the same contents as shown in Table 6 below using Experimental Example 11 as a main component and sweeteners, flavors, preservatives, acidity regulators, thickeners and the like, which are commonly used excipients for beverages.

Hangover drink Raw material name content(%) Cultured mycelium 10 Mixed extract A (health, dermis, broiler) 2 Green tea extract 0.01 Indigestible maltodextrin 5 Acorn extract 0.05 Hounsu extract 0.1 Flavor Suitable amount Acidity control agent Suitable amount Thickener Suitable amount Distilled water Up to (sum) 100.00

As shown in Table 6, the contents of the mixture were uniformly mixed in distilled water using a high-speed stirrer, sterilized at high temperature, and put into bottles or cans to prepare ordinary beverages.

[ Product example  2. Health functional foods Manufacturing example ]

Tablets were prepared as described below using Experimental Example 11 as a main component and excipients commonly used in health functional foods

Health functional foods Raw material Formulation ratio (%) Cultured mycelium 10 Mixed extract A (health, dermis, broiler) 2 Green tea extract 0.01 Indigestible maltodextrin 5 Garlic extract 0.01 Bamboo extract 0.009 Vitamin B1 1.7 Vitamin B2 1.0 Vitamin C 2.6 Flavor Suitable amount Excipient Suitable amount (sum) 100.00

The above preparation example is a preparation example for producing ordinary tablets containing the hangover resolution composition and does not limit the formulations and raw materials of the present invention.

[ Product example  3. Concentrate Manufacturing example ]

A concentrate was prepared in the same amounts as shown in Table 8 below using Experimental Example 11 as a main component and sweeteners, flavors, preservatives, acidity regulators, thickeners and the like which are commonly used in liquid products.

concentrate Raw material name content(%) Cultured mycelium 10 Mixed extract A (health, dermis, broiler) 2 Green tea extract 0.01 Indigestible maltodextrin 5 Hounsu extract 0.2 Vitamin B2 0.005 oligosaccharide Suitable amount Fruit concentrate Suitable amount honey Suitable amount Distilled water Up to (sum) 100.00

The contents of the mixture shown in Table 8 were uniformly mixed in distilled water using a high-speed stirrer, filled in a polyethylene bag and retorted to prepare a pouch concentrate.

The above preparation example is a preparation example for producing a conventional liquid product containing the present hangover resolution composition and does not limit the formulations and raw materials of the present invention.

Claims (8)

Health, dermis and broiler mixed extracts; Cultured mycelium; Green tea extract; And indigestible maltodextrin. The composition for removing hangover according to claim 1, wherein the mixed extracts of health, dermis and broiler are mixed in a weight ratio of 1: 1.5 - 3: 0.5 - 2 on a dry matter basis. The composition according to claim 1, which comprises 0.2 to 30% by weight of a mixed extract of health, dermis and broiler chickens, based on the total weight of the composition; 1 to 50% by weight of a culture of anthrax mycelium; 0.001 - 10% by weight of green tea extract; And 0.5 to 30% by weight of an indigestible maltodextrin. The composition according to claim 1, which comprises 1 to 10% by weight of a mixed extract of health, dermis and broiler chickens, based on the total weight of the composition; 5 to 30% by weight of a mycelium culture; 0.005 - 5% by weight of green tea extract; And 3 to 13% by weight of an indigestible maltodextrin. [3] The composition for relieving hangover according to claim 1, further comprising at least one extract selected from the group consisting of garlic extract, ginseng extract, spinach extract or horn extract. [Claim 6] The composition according to claim 5, which comprises 0.001-1% by weight of garlic extract, 0.001-1% by weight of ganoderma lucidum extract, 0.005-1% by weight of spinach extract or 0.001-1% by weight of hinoki extract, A composition for relieving hangovers. A hangover eliminating food comprising the composition for relieving hangover according to any one of claims 1 to 6. A hangover remedy comprising the composition for relieving hangover according to any one of claims 1 to 6.