KR100500373B1 - Composition for hangover cures - Google Patents

Abstract

The present invention relates to a hangover relief composition and a health functional food containing the same, and more particularly, to a hangover relief composition comprising extracts of dermis, baekbokyeong, injin, browning and brown root, overall hangover symptoms due to drinking It has an excellent resolving action against, and has no side effects on the human body, and has an excellent hepatoprotective effect so that it can be used for hangover relief before or after drinking.

Description

Hangover cures {Composition for hangover cures}

The present invention relates to a hangover relieving composition and a health functional food containing the same, and more particularly to a hangover relieving composition comprising the extract of the dermis, baekbokyeong, injin, browning and root.

The hangover is caused by the poisoning effect of ethanol or acetaldehyde accumulated in hepatocytes, and if these substances accumulate in the liver cells for a long time and cause poisoning, symptoms such as fatigue, general boredom, bloating, and vomiting are caused.

Normal metabolism of ethyl alcohol when it enters the body is absorbed by the stomach or small intestine and enters the blood vessels and is transferred to the liver. Hepatocytes contain alcohol dehydrogenases, which oxidize alcohols to acetaldehyde, which are decomposed into acetic acid by acetaldehyde dehydrogenases in hepatocytes, which are transferred to muscle and adipose tissue throughout the body and finally to carbon dioxide and water. will be.

In addition, the acetaldehyde enzyme has type II which initiates oxidation even at low concentrations of acetaldehyde and type I which does not work unless acetaldehyde does not have high concentration, but oriental people generally lack or lack acetaldehyde enzyme because acetaldehyde is deficient. Oxidation is slow, and thus normal metabolism is disturbed by the poisoning of acetaldehyde or ethyl alcohol, which is not oxidized, resulting in various hangover phenomena.

In order to alleviate the hangover after drinking alcohol, a large number of drinks prepared by mixing or combining herbal preparations or artificial preparations have been developed. As a herbal or folk remedy, nourishment tonic drinks have been developed that are mainly composed of ginseng and ginseng, which are known to be effective in relieving hangover. However, these preparations and drink products are effective only in the items of some of the various changes caused by drinking, the drug is also shown to be inadequate. In addition, in the case of the invention of the herbal extracts improved to improve the use of herbal extracts that have been used almost as a conventional herbal preparations, it is not the best prescription for hangover relief.

Accordingly, the present inventors have intensively studied, and completed the present invention by developing a novel hangover relief composition having an excellent resolution for the overall hangover symptoms caused by drinking.

An object of the present invention is to provide a hangover relief composition that has an excellent resolution for the hangover symptoms caused by drinking, and also has no side effects on the human body, and can be used before or after drinking with excellent hepatoprotective effects.

Another object of the present invention to provide a health functional food comprising the composition.

In order to achieve the above object, the present invention provides a hangover relief composition comprising a water extract or alcohol extract of dermis, baekbokyeong, jinjin, browning and brown root.

In the composition of the present invention, the extract is extracted by mixing the raw material herbal dermis, baekbokyeong, phosphorus, browning and brown root in a weight ratio of 1 to 5: 1 to 5: 3 to 25: 1 to 5: 1 to 5, or It is preferable to extract the herbal medicines and mix them in the above weight ratio.

In addition, the composition of the present invention may further comprise one or more extracts selected from the group consisting of extract, licorice, broiler, ginger, cod, powder, mountain sand and malt and alcohol extract.

In one preferred embodiment of the present invention, the dermis, baekbokyeong, injin, browning, brown root, creation, licorice, broiler, ginger, cod, powder, 1 ~ 5: 1 ~ 5: 3 ~ 25: 1 -5: 1-5: 0.5-3: 0.5-3: 0.5-3: 1-10: 0.3-3: 0.3-3: 0.3-3: 0.3-3, or each herbal extract is extracted, It is preferable to mix in the said weight ratio.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

In the composition of the present invention, each of the herbal medicines can be extracted by a conventional method and mixed with the extract, or after mixing the herbal medicines can be extracted all at once, and if necessary it can be concentrated to dry powdered.

In the present invention, preferably, each herbal medicine is mixed in a prescribed weight ratio, and then extracted with conventional methods such as hot water extraction and sonication using water or alcohol as a solvent. If alcohol is used, it is preferred to use methanol or ethanol.

The raw material for the preparation of the composition according to the present invention is preferably a mixture of dermis, baekbokyeong, phosphorus, browning and brown root in a weight ratio of 1 to 5: 1 to 5: 3 to 25: 1 to 5: 1 to 5, and particularly preferred. Preferably, the composition contains at least one herbal medicine of licorice, licorice, broiler, ginger, cod, powder, hawthorn or malt, based on the weight of the dermis 0.5 to 3: 0.5 to 3: 0.5 to 3: 1 to 10: 0.3 to 3 The mixture may be further mixed in a weight ratio of 0.3 to 3: 0.3 to 3: 0.3 to 3.

The composition ratio of the herbal medicines is obtained on the basis of repeated experimental results, and when lower than the lower limit, the physiological activity effect of the component is reduced, and when higher than the upper limit, the physiological activity effect of the other components may be reduced, thereby synergistically And there is a fear that the cooperation is lowered.

The composition of the present invention is 200g: 100g: 600g: 200g: 200g: 100g: 100g: 50g: dermis, baekbokyeong, jinjin, browning, brown root, creation, licorice, broiler, ginger, coriander, powder, hawthorn and malt 1 g of water is poured into the mixture obtained by mixing 300 g: 100 g: 100 g: 100 g: 100 g, decocted for about 2 hours, and concentrated to about 300 ml.

The compositions of the present invention may be formulated by methods known in the pharmaceutical art and may be mixed with the extract itself or with a pharmaceutically acceptable carrier, excipient, etc., to form a conventional pharmaceutical preparation, for example liquids such as drinks, syrups, capsules. Formulations and the like, which can be administered orally or parenterally. The composition of the present invention is preferably administered orally before and / or after drinking as a drink for quick effect.

The liquid, capsules and the like containing the composition of the present invention is preferably used as a health functional food, the term "health functional food" used in the present invention is used as a raw material or ingredient having a useful functionality to the human body Refers to food products manufactured and processed in the form of tablets, capsules, powders, granules, liquids, and pills.

The composition of the present invention is appropriately selected depending on the absorption of the active ingredient in the body, the rate of excretion, the age and weight of the patient, the sex and condition, the severity of the disease to be treated, etc. 1.0 to 5 ml, which is taken 1 to 3 times a day. In other formulations, an appropriate amount calculated in consideration of the liquid dosage can be administered orally.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited by them in any way.

Example 1 Preparation of Liquid

200 g of dermis, 150 g of Baekbokryeong, 600 g of phosphorus, 150 g of browning and 150 g of brown root were mixed and then poured into 800 ml of water, decocted for about 2 hours, and concentrated to about 200 ml to prepare a liquid formulation.

Example 2: Preparation of Liquid

After mixing 200 g of dermis, 200 g of Baekbokryeong, 600 g of phosphorus, 150 g of browning, 200 g of brown root and 150 g of production, 600 ml of ethanol was poured into it, extracted by sonication, and concentrated under reduced pressure (yield 5.8%). 200 ml of distilled water was added to the concentrate, followed by filtration to prepare a liquid.

Example 3: Preparation of Liquid

200g of dermis, 100g of Baekbokryeong, 1000g of phosphorus, 200g of gallium, 200g of brown root, 100g of ginseng, 50g of broiler, 100g of medicinal herb, and then poured 900ml of water, decoction for about 2 hours and concentrated to about 250ml to prepare a liquid formulation. .

Example 4: Preparation of Liquid

150g of dermis, 150g of Baekbokyeong, 800g of ginseng, 200g of lignite, 200g of brown root, creation 80g, 100g of licorice, 50g of cod, 50g of acid and 50g of ginger, and then poured 900ml of water, decoction for about 2 hours, and then about 250ml Concentration prepared a liquid.

Example 5: Preparation of Liquid

200 g of dermis, 100 g of Baekbokryeong, 600 g of ginseng, 200 g of lignite, 200 g of brown root, creation 100 g, licorice 100 g, broiler 50 g, 300 g of ginger, 100 g of cabbage, 100 g of cod, 100 g of hawthorn and 100 g of malt, and then pour 1 liter of water , Decoction for about 2 hours and concentrated to about 300ml to prepare a liquid.

Example 6: Preparation of Other Formulations

Pills, granules, tablets or capsules were prepared from each of the extracts of Examples 1 to 5 according to conventional methods.

Experimental Example 1. Measurement of blood concentration

In order to measure the hangover effect on the compositions of Examples 1 and 5, blood alcohol concentration test was performed on 50 healthy adults (37 males, 13 females) in their 30s. Fifty patients were divided into a control group (10), a combat female group (20 persons), and a post-administration group (20 persons). Each of them was allowed to drink a bottle of 360 ml of soju, and blood alcohol levels were measured by a conventional method. Combat female is a group taking 100ml each of the composition of Example 1 or Example 1 hour before drinking soju, the post-administration group is a group taking 100ml each of the composition of Example 1 or Example 5 immediately after ingesting soju. The results are shown in Table 1 below (values represent mean ± standard deviation).

Table 1 (Unit:%)

Immediately after drinking 1 hour 3 hours 5 hours Control 0.11 ± 0.012 0.10 ± 0.012 0.06 ± 0.025 0.02 ± 0.001 Composition administration group of Example 1 0.11 ± 0.023 0.07 ± 0.026 0.03 ± 0.013 0.01 ± 0.001 Composition administration group of Example 5 0.115 ± 0.01 0.06 ± 0.028 0.02 ± 0.018 0.00 Composition after administration group of Example 1 0.11 ± 0.017 0.06 ± 0.019 0.02 ± 0.009 0.00 Composition after administration group of Example 5 0.117 ± 0.013 0.05 ± 0.021 0.015 ± 0.009 0.00

As shown in Table 1, the concentration of alcohol in the blood was significantly reduced compared to the control group not administered the composition of the compositions of Examples 1 and 5 of the present invention before and after drinking.

Experimental Example 2. Measurement of hangover relief

The composition of Example 1 or 5 was administered to 50 adults of Experimental Example 1 as in Experimental Example 1, and a test for elimination of hangover after 7 hours after drinking was performed. The results are shown in Table 2 below. (Values represent mean ± standard deviation).

TABLE 2

Fatigue headache Telegraphy Bloating Nausea Control 5 ± 1.2 4 ± 1.5 5 ± 0.2 4 ± 1.5 3.8 ± 2.6 Composition administration group of Example 1 1.5 ± 1.5 1 ± 0.5 1.5 ± 0.5 1 ± 2.3 1 ± 1.2 Composition administration group of Example 5 2.0 ± 0.5 0 1.0 ± 0.2 2.0 ± 1.0 0 Composition after administration group of Example 1 1 ± 1.2 0.5 ± 0.1 0 1.5 ± 0.2 1 ± 0.7 Composition after administration group of Example 5 1 ± 0.2 0 1 ± 0.3 0 0

(Note) The degree of symptoms is as follows.

5: very severe; 4: severe; 3: normal; 2: mitigation; 1: weak; 0: none

As shown in Table 2, when taking the compositions of Examples 1 and 5 of the present invention before and after drinking, all symptoms such as fatigue, general boredom, bloating, vomiting, etc. are symptoms of hangover.

As can be seen from the above, the composition of the present invention has an excellent resolution for the overall hangover symptoms due to drinking, and also has no side effects on the human body, and has an excellent hepatoprotective effect to be used for hangovers before or after drinking. Can be.

Claims (6)

delete delete delete Dermis, Paekbokyeong, Injin, Brownish, Brown root, Produce, Licorice, Broiler, Ginger, Sine, Potion, Sansa and Malt Weight ratio 1-5: 1-5: 3-25: 1-5: 1-5: 0.5-3 : 0.5 to 3: 0.5 to 3: 1 to 10: 0.3 to 3: 0.3 to 3: 0.3 to 3: 0.3 to 3 and extracted with water, methanol or ethanol, or each herbal medicine with water, methanol or ethanol Extraction and hangover composition extracted by the weight ratio. delete delete