KR100392876B1 - A drink for eliminating a hangover and a method for producing the same - Google Patents

Abstract

The present invention relates to a hangover drink excellent in the hangover removal effect, and a method for producing the same. More specifically, the present invention contains a extract of Purataria lobata, Milk thistle seeds, Taurine, and Tumeric extract as main ingredients, and has a great hangover removal effect after drinking, And a method for producing the same.

Description

Hangover drink and its manufacturing method

The present invention relates to a hangover drink excellent in the hangover removal effect, and a method for producing the same. More specifically, the present invention contains the extract of Purataria lobata, Milk thistle seed, Taurine, and Tumeric extract as main ingredients, and in particular, synergistically, hangover removal effect after drinking And a method for producing the same.

Drinking is becoming essential for modern people who have frequent drinking and entertainment and are stressed by various factors, and drinking opportunities have increased considerably.

According to the results of the National Health and Nutrition Survey conducted by the Korean Institute of Health and Human Services under the Ministry of Health and Welfare, the average drinking time for Korean adults over 20 years is about 8 days a month, about 11 days for men and about 4 days for women. At this time, the frequency of intoxication was about 4.7% at least once a week, about 10.7% at 1 to 3 times a month, and about 13.2% at 1 to 3 times a month. At the level of considerable concern.

As such, modern people consume excessive amounts of alcohol that are too indigestible and cause side effects such as thirst, general boredom, fatigue, memory loss, abdominal bloating, indigestion, vomiting diarrhea and vitamin deficiency. Many people suffer from the phenomenon, and the risk of alcoholism increases.

Alcohol is acetaldehyde in the body by alcohol dehydrogenase (ADH), which in turn is converted to acetic acid by aldehyde dehydrogenase (ALDH), which finally becomes carbon dioxide and water, And water is excreted in the kidneys.

ADH is always present in the human body. However, in the case of ALDH in which two forms of ALDH ₁ and ALDH ₂ exist, ALDH ₂ is usually owned by most people, but ALDH ₁ varies by ethnic group, about 50% in Asians and about 35% in Koreans. It is deficient. Therefore, Koreans are known to suffer from acetaldehyde syndrome, such as redness of the face or body, vomiting, headache, etc., not only by the direct action of ethanol but also by the action of acetaldehyde.

If you look at the causes of alcohol damage to the liver, when ADH converts ethanol to acetaldehyde, NAD ⁺ is used to produce a lot of NADH, which affects the metabolism of other substances, lowers fatty acid metabolism, and fat accumulates in the liver. Fatty liver. Acetaldehyde impairs organelles such as mitochondria in hepatocytes, and is caused by hyperactivity of alcohol metabolism, resulting in a hypoxic state. In addition, alcohol itself causes cell membrane failure of hepatocytes.

Therefore, studies have been actively conducted on preparations that can eliminate hangovers caused by alcohol intake and reduce blood alcohol concentrations.

However, a prescription containing a hangover remover using conventional browning, for example, browning, softening skin, Mokyang, tangerine, ginseng, spirit, Baekbokyeong, Shinguk, Taeksa, dried ginger, Baekchul, Baekdu-in, and sign, etc. There was a discomfort to be taken by month, or made of pills or powder, and the hangover removal effect was not very good, and the other effect of the hanger remover containing conventional browning was not as good as desired. In the case of products containing a plant extract as a main ingredient or products containing embryos and soy extracts, many problems still need to be solved in terms of stability, and many of the artificial or herbal preparations prepared alone or in combination Some of the drinks, especially artificial ones, cause side effects such as headaches, abdominal pain and vomiting during drinking. The dots were.

The present inventors have conducted extensive research to solve the above-mentioned conventional problems, the formulation containing the browning extract, thistle seed extract, taurine and turmeric extract as the main component shows an excellent effect on liver function recovery, hangover removal, The present invention has been found to be a convenient and stable drink to take.

Accordingly, it is an object of the present invention to provide a hangover removal beverage containing a browning extract, a large thistle seed extract, a taurine and turmeric extract as a main component, and a manufacturing method thereof.

Another object of the present invention is one or more herbal preparations, fruit juice, vegetable juice, sugar, fructose, and the like, which are selected from the group consisting of licorice plum, jujube, wolfberry and ganoderma To provide a hangover removal beverage, and a method for producing the hangover further comprises one or more of sugars, water-soluble vitamins, citric acid and royal jelly selected from the group consisting of honey.

In order to achieve the object of the present invention, the present inventors, first, the browning extract is dried in the usual way, as described in Korean Patent Application No. 95-15493, that is, water of 5 to 10 times the weight of browning. The hot water extracted for about 1 hour using was used as the raw material for the grinding of the beverage of the present invention. However, in the present invention, it is also possible to use a galvanic extract obtained by extracting both a water-soluble substance and an alcohol-soluble component by using a hydrothermal extract of gallium, or by extracting primary hydrothermal and secondaryly extracting with alcohol.

Gallium, which is one of the main constituents of the beverage for removing hangover of the present invention, includes flavonoids such as vininine, genistein, isoflavone, dydzein, quercetin, essential oils, benzoic acid, propionic acid, and coumaric acid. Of these, rovinin is known to have a diuretic effect and a decrease in the residual nitrogen content in blood, and is mainly related to detoxification, and dyedzein is known to act on various heart failures such as migraine, hypertension and angina. have. In addition, as a result of the toxicity test using the gallium extract, it is described in Korean Patent Application No. 95-15493 that its LD ₅₀ is safe to 9000 mg / kg or more.

Milk thistle seed extract may be extracted from conventional thistle seeds by conventional methods, or may be concentrated, purified, and dried to obtain a high content of Silymarin, an active ingredient of the seed extract, up to 70%. Raw materials, such as a dry extract, for example, the drug Legalon of Madaus Germany, can be used.

Milk thistle is a plant native to Southern Europe, Asia Minor and North Africa. It is also distributed in North and South America, South Australia, Central Europe, Central and East Asia. Thistle is a 1-2 year old herbaceous plant that grows to around 1m in height. The scientific name is Silybum marianum (L) Gaertn, and the English names are Milk Thistle, Mary Thistle, Lady's Thistle, Holly Thistle, and so on.

Thistle seed is a medicinal plant that has been widely used in Europe for over 2000 years as a folk medicine for diseases such as liver, gallbladder, digestive tract, spleen, etc. It is approved as an adjuvant therapeutic drug for hepatitis and cirrhosis, and many of these large thistle seed-use products have been released in the United States and Japan due to its effect on improving liver function.

The active ingredient of thistle seed extract is the flavonolignans such as the isomers Silybin, Silydianin, and Silychristin, which are commonly referred to as silymarins. Among the silymarins, silybin is known as the most bioactive component, and silymarin is contained in the content of 1.5 to 3% in thistle seeds. Silymarin stabilizes liver cell membranes directly or indirectly, blocking harmful substances from entering the hepatocytes, enhancing liver detoxification, and promoting regeneration of normal hepatocytes, improving liver function, which has been confirmed by many clinical trials. It is known to be effective against various types of hepatic diseases, including injury, drug-induced liver injury and cirrhosis. For the acute toxicity of silymarin was investigated in different types of animals, mice in the 20 g / kg, more in 1 g / had never had the side effect by oral administration of kg, LD ₅₀ in the silica blank intravenous administration in mice 1010 mg / kg, 873 mg / kg in rats and 300 mg / kg in rabbits. Silymarin was orally administered to rats at 1 g / kg for 15 days with no side effects, and rats were also given 1000 mg / kg / day Long-term oral administration of 16 to 22 weeks at the dose of no side effects, and no effects on the fetus in pregnant rats, rabbits are not observed at all is safe even in the long term.

On the other hand, taurine, which is a kind of amino acid, promotes bile production and promotes the excretion of waste accumulated in the liver, and shows the effect of improving liver function. According to the conventional research results, it is possible to reduce acetaldehyde syndrome, which is easily seen in Asians, and various liver diseases, eg For example, it has been proved effective for chronic hepatitis, fatty liver, cirrhosis, etc., and for the treatment of alcohol withdrawal symptoms. It is also known that taurine is a safe, nontoxic material.

Turmeric extract can be used to extract the conventional method. Turmeric is the scientific name Curcuma aromatica Salisb, and turmeric is also called Bomb Ukon. Ukon is a perennial herb belonging to the Gingeraceae family, which grows in hot and humid regions, and is currently distributed in a wide range of regions from the tropics to the subtropics. Curcumin of turmeric extract has the effect of strengthening liver function, diarrhea, diuretic, bactericidal, antibacterial, anti-inflammatory, and anti-cholesterol, which promote the secretion of bile. It also functions.

In the case of a gallium extract, the content thereof is preferably 1 to 30 ml, particularly 5 to 15 ml, based on 100 ml of the beverage, and the milk thistle seed extract is such that the content of silymarin is 140 to 500 mg, especially 210 to 420 mg. Preferably, the taurine is preferably from 0.1 to 3.5 g, in particular from 0.5 to 3 g, and the turmeric extract is such that the content of coocumin is from 400 to 600 mg.

The beverage of the present invention comprises one or more components selected from licorice, jujube, plum, wolfberry, ganoderma lucidum, honey, etc., which are traditional herbal materials active in human metabolism, mainly composed of gallium extract, thistle seed extract, taurine, and turmeric extract, If necessary, it may contain pear juice, apple juice and citric acid, which can give a cool taste and acidity, and vitamin B ₁ , B ₂ , B ₆ , C and royal jelly to reinforce vitamins that are easily consumed in alcohol metabolism. Can be.

The amount of licorice extract was found to be preferably 0.5 to 3.0 ml based on 100 ml of beverage, and the sour and fresh flavor was good when the amount of plum extract was 0.1 to 3.0 ml. The ganoderma lucidum may not be more than 3.0 ml based on 100 ml of drink because of its bitter taste. Juices such as pear juice, apple juice and lemon essence are added to add freshness to the beverage. It is preferable to be included in the range of. Vitamin B ₁ , B ₂ , B ₆ , vitamin C, etc. may be added to the beverage of the present invention to reinforce vitamins that are easily consumed during alcohol metabolism, and the amount thereof may be 0.2 ml or less based on 100 ml of beverage. It is desirable to limit.

For example, based on 100 ml of beverage, 0.5 to 8.0 ml of pear juice, 0.5 to 7.0 apple juice, 0.5 to 5.0 ml of honey, 5.0 to 15.0 ml of fructose, 0.001 to 0.01 ml of vitamin B ₁ , and 0.001 of vitamin B ₂ To 0.01 ml, vitamin B ₆ is 0.001 to 0.01 ml, vitamin C is 0.001 to 0.05 ml, citric acid is 0.1 to 0.5 ml, royal jelly may be preferably 0.005 to 0.05 ml.

In addition to the above components, the beverage of the present invention may contain various materials and flavors, preservatives, preservatives and the like used in conventional beverages in an appropriate amount.

Hereinafter, the preparation method of the hangover drink according to the present invention will be described with reference to Examples, but the present invention is not limited by these Examples.

(Example)

The brownish extract, thistle seed extract, taurine and turmeric extract extracted by a conventional method and purified water were put in a mixing tank so as to have the composition of Table 1, which was heated to 50 ° C. and sufficiently stirred so that the formulations were completely dissolved.

Upon completion of the formulation, the filtration was clarified in an ultrafiltration apparatus using a 5 μm filter and a microfiltration device of 0.45 μm or less in order to remove precipitates or suspended solids.

The obtained clarifier was injected into a suitable glass bottle container immediately after being heated at 80 ° C. for 30 seconds to 90 seconds through a heat exchanger, and was immediately sealed.

The sterilized jars were cooled to 40 ° C. to obtain the beverage of Example 1.

Meanwhile, other additives such as licorice, plum, jujube, goji berry extract, and ganoderma lucidum, which are auxiliary components, are ground and concentrated under reduced pressure after juice extraction, and then natural flavors are added, followed by pear juice, apple juice, and other ingredients and purified water. It was put in a mixing tank so as to mix with the composition of Example 1 and then prepared in the same manner as in Example 1 to obtain a beverage of Example 2.

The beverages of Examples 3 and 4 were prepared similarly to the above.

ingredient Example 1 Example 2 Example 3 Example 4 Gallium Extract (45 ^o Bx) 15 ml 15 ml 15 ml 15 ml Silymarin Content in Milk Thistle Seed Extract 210 mg 210 mg 210 mg - Taurine 2 g 2 g - 2 g Content of Curcumin in Turmeric Extract 400 mg 400 mg 400 mg 400 mg Licorice Extract (3.0 ^o Bx) - 0.65ml 0.65ml 0.65ml Plum Extract (40 ^o Bx) - 0.20ml 0.20ml 0.20ml Jujube Extract (40 ^o Bx) - 0.30ml 0.30ml 0.30ml Wolfberry Extract (40 ^o Bx) - 0.35ml 0.35ml 0.35ml Ganoderma lucidum extract (1 ^o Bx) - 0.56ml 0.56ml 0.56ml Pear Juice (11 ^o Bx) - 0.64ml 0.64ml 0.64ml Apple Juice (11 ^o Bx) - 0.34ml 0.34ml 0.34ml High fructose - 11.5ml 11.5ml 11.5ml honey - 0.97ml 0.97ml 0.97ml Citric acid - 0.1ml 0.1ml 0.1ml Malic acid - 0.1ml 0.1ml 0.1ml Sodium citrate - 0.03ml 0.03ml 0.03ml Sodium benzoate - 0.02ml 0.02ml 0.02ml Sorbitol - 0.39ml 0.39ml 0.39ml Vitamin B ₁ - 0.001ml 0.001ml 0.001ml Vitamin B ₂ - 0.002ml 0.002ml 0.002ml Vitamin B ₆ - 0.002ml 0.002ml 0.002ml Vitamin c - 0.025ml 0.025ml 0.025ml Royal Jerry - 0.015ml 0.015ml 0.015ml Lemon essence - 0.115ml 0.115ml 0.115ml Purified water Volume to make 100ml Volume to make 100ml Volume to make 100ml Volume to make 100ml

Comparative Example 1

The beverage described in Example 1 of the applicant's Korean Patent Application No. 95-15493 as a main component and further containing components such as licorice, plum, jujube, and the like was used as Comparative Example 1.

Effect test

The effects of the beverage of the present invention on the ethanol metabolism of the experimental animals were tested in the following manner by administering the obtained Examples 1 to 4 and the beverage of Comparative Example 1 to the animals.

Experimental Animals: Three week old Sprague-Dawley rats were used. The experimental animals were used for the experiment after adapting to the nursery environment for 3 weeks. During the breeding and experiment period, the temperature was maintained at 24 to 26 ° C, and 2 to 5 animals were raised in a cage for rats.

Feed and drinking water: Feed was fed freely and distilled water was used.

Experimental Methods: Except for the beverages of Examples 1 to 4 and Comparative Example 1, which contained drinking water only and fasted for 24 hours, did not contain the beverages of Examples 1 to 4 and Comparative Example 1, and browned extract, thistle seed extract, taurine, and turmeric extract. Drinks having the same ingredients as in Example 2 (Control 1) were each administered in an amount of 1.67 ml / kg via stainless steel sonde (10 cm), and control group 2 was administered only saline. Ten minutes after the administration, 2.0 ml / kg of ethanol was administered. Each group was tested with 5 to 6 animals. One hour after the administration of ethanol, the experimental animals sacrificed by oral extraction were dissected to extract brains and livers. Brain and liver were weighed and treated with Krebs original Ringer Phosphate at 0.5 ml / g tissue weight and treated below 4 ° C. The brain and liver were homogenized with a tissue homogenizer (Biospec Products, Model M133 / 1281-0), then 180 μl were transferred to an Eppendorf tube, 0.5 ml of methylene chloride was added, and vigorously stirred with a vortex mixer. It was analyzed by GC-FID (Hewlet Packard HP5890; column, HP-1, 30 m, φ = 0.53 mm) while treating with a small amount of anhydrous magnesium sulfate to remove moisture, stirring and storing in ice water. The amount of ethanol was calculated based on the regression line obtained from the standard curve between ethyl acetate and ethanol and ethyl acetate used as internal standard.

result:

Treatment group Relative alcohol concentration (100 = 0.92 mg EtOH / ml blood) Control group 1 98 ± 6.1 Control 2 100.0 ± 2.0 Example 1 55 ± 5.0 Example 2 52 ± 7.2 Example 3 70 ± 5.5 Example 4 72 ± 7.3 Comparative Example 1 75.5 ± 11.1

As can be seen from the above results, when a beverage (Examples 1 and 2) containing simultaneously the browning extract, thistle seed extract, taurine, and turmeric extract is administered to the animal, the conventional browning extract-containing beverage Compared with (Comparative Example 1), it was found that alcohol metabolism was significantly promoted after 1 hour of alcohol consumption. In addition, it was found that the beverage containing the browned and large thistle seed extract (Example 3), and the browned and taurine (Example 4) had an almost similar level of alcohol metabolism promoting activity as the beverage of Comparative Example 1. Therefore, it can be seen that the main components of the beverage of the present invention, such as browning extract, thistle seed extract, taurine and the like have a synergistic effect with each other.

Storage experiment

When the beverage prepared according to Example 2 was stored for 4 weeks in a 40 ° C. constant temperature thermostat, the results of the weekly changes in appearance and sensory deterioration of the product were not found.

As described above, the beverage according to the present invention simultaneously containing the browning extract, thistle seed extract, taurine, and turmeric extract, there is no problem of discomfort when taking, faster absorption in the body, hangover removal effect Excellent, satisfactory in palatability when drinking, and excellent in stability.

Claims (6)

Based on 100 ml of the beverage, 1 to 30 ml of gallium extract, large thistle seed extract containing 140 to 500 mg of silymarin, turmeric extract containing 400 to 600 mg of coucumin, and 0.1 to 3.5 g of taurine. Hangover beverage to drink. The method of claim 1, wherein the browning extract is 5 to 15ml, thistle seed extract is Silymarin content of 210 to 420 mg, taurine is 0.5 to 3 g, drink for hangover. According to claim 1 or 2, Hangover drink characterized in that it further contains 0.5 to 25ml of one or more herbal extracts selected from the group consisting of licorice, plum, jujube, wolfberry and ganoderma on the basis of 100 ml of the beverage . According to claim 3, at least one of 0.5 to 15 ml of fruit juice, 0.5 to 20 ml of sugar selected from fructose and honey, 0.001 to 0.2 ml of water-soluble vitamins, 0.1 to 0.5 ml of citric acid and 0.005 to 0.05 ml of royal jelly based on 100 ml of beverage. Hangover drink characterized in that it further comprises. The fruit juice of claim 4, wherein the fruit juice has 0.5 to 8.0 ml of pear juice, 0.5 to 7.0 ml of apple juice, 0.5 to 5.0 ml of honey, 5.0 to 15.0 ml of fructose, and vitamin B ₁ is 0.001 to 0.01 ml, vitamin B ₂ is 0.001 to 0.01 ml, vitamin B ₆ is 0.001 to 0.01 ml, vitamin C is 0.001 to 0.05 ml, citric acid is 0.1 to 0.5 ml, royal jelly is 0.005 to Hangover drink, characterized in that 0.05ml. Based on 100 ml of beverage, 1 to 30 ml of gallium extract, large thistle seed extract containing 140 to 500 mg of silymarin, turmeric extract containing 400 to 600 mg of coumin, 0.1 to 3.5 g of taurine, licorice, plum, jujube, wolfberry 0.5 to 25 ml of one or more medicinal herb extracts selected from ganoderma lucidum, 5 to 20 ml of components selected from fruit juices and sugars are mixed with purified water, dissolved by heating to 40-50 ° C., stirred, filtered and then heat sterilized. Method for producing a drink for removing the hangover characterized in that.