KR100392876B1 - A drink for eliminating a hangover and a method for producing the same - Google Patents
A drink for eliminating a hangover and a method for producing the same Download PDFInfo
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- KR100392876B1 KR100392876B1 KR10-2001-0023251A KR20010023251A KR100392876B1 KR 100392876 B1 KR100392876 B1 KR 100392876B1 KR 20010023251 A KR20010023251 A KR 20010023251A KR 100392876 B1 KR100392876 B1 KR 100392876B1
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- Prior art keywords
- extract
- hangover
- beverage
- drink
- vitamin
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Classifications
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L2/38—Other non-alcoholic beverages
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
본 발명은 숙취제거 효과가 우수한 숙취제거용 음료, 및 그의 제조 방법에 관한 것이다. 더욱 상세하게는, 본 발명은 갈화 (Purataria lobata) 추출물, 큰엉겅퀴 (Milk thistle) 종자 추출물, 타우린 및 울금 (Tumeric) 추출물을 주요 성분으로 함유하여, 음주후의 숙취 제거 효과가 탁월한 숙취제거용 음료, 및 그의 제조 방법에 관한 것이다.The present invention relates to a hangover drink excellent in the hangover removal effect, and a method for producing the same. More specifically, the present invention contains a extract of Purataria lobata, Milk thistle seeds, Taurine, and Tumeric extract as main ingredients, and has a great hangover removal effect after drinking, And a method for producing the same.
Description
본 발명은 숙취제거 효과가 우수한 숙취제거용 음료, 및 그의 제조 방법에 관한 것이다. 더욱 상세하게는, 본 발명은 갈화 (Purataria lobata) 추출물, 큰엉겅퀴 (Milk thistle) 종자 추출물, 타우린 및 울금 (Tumeric) 추출물을 주요 성분으로 함유하며, 특히 이들의 상승작용에 의해 음주후의 숙취 제거 효과가 탁월해진 숙취제거용 음료, 및 그의 제조 방법에 관한 것이다.The present invention relates to a hangover drink excellent in the hangover removal effect, and a method for producing the same. More specifically, the present invention contains the extract of Purataria lobata, Milk thistle seed, Taurine, and Tumeric extract as main ingredients, and in particular, synergistically, hangover removal effect after drinking And a method for producing the same.
회식과 접대가 잦고, 여러 가지 요인에 의한 스트레스가 많은 현대인들에게 음주는 필수적인 것으로 자리잡고 있으며, 그로 인하여 음주기회가 상당히 증가하고 있다.Drinking is becoming essential for modern people who have frequent drinking and entertainment and are stressed by various factors, and drinking opportunities have increased considerably.
보건복지부 산하 한국보건사회 연구원이 실시한 국민건강 영양 조사결과에 의하면, 우리나라 20세 이상 성인의 경우, 술마시는 날은 1달 평균 약 8일이며, 남자는 약 11일, 여자는 약 4일 정도인 것으로 나타났고, 이 때 만취 횟수는 주 1회 이상이 약 4.7% 정도, 1개월에 1 내지 3회가 약 10.7% 정도, 3개월에 1 내지 3회가 약 13.2%로서, 이는 국민 건강의 측면에서 상당히 우려할 만한 수준이다.According to the results of the National Health and Nutrition Survey conducted by the Korean Institute of Health and Human Services under the Ministry of Health and Welfare, the average drinking time for Korean adults over 20 years is about 8 days a month, about 11 days for men and about 4 days for women. At this time, the frequency of intoxication was about 4.7% at least once a week, about 10.7% at 1 to 3 times a month, and about 13.2% at 1 to 3 times a month. At the level of considerable concern.
이와 같이, 현대인들은 그 정도가 지나쳐 소화할 수 없을 정도의 과량의 알코올을 섭취하고 그로 인한 부작용인 갈증, 전신권태, 피로감, 기억상실, 복부 팽만감, 소화 불량, 구토 설사, 비타민 결핍 현상 등의 숙취 현상으로 고생하는 경우가 많고, 알코올 중독에 걸릴 위험성도 그만큼 증가한다.As such, modern people consume excessive amounts of alcohol that are too indigestible and cause side effects such as thirst, general boredom, fatigue, memory loss, abdominal bloating, indigestion, vomiting diarrhea and vitamin deficiency. Many people suffer from the phenomenon, and the risk of alcoholism increases.
알코올은 체내에서 알코올 데히드로게나아제(ADH)에 의해 아세트알데히드로 되는데, 이것은 다시 알데히드 데히드로게나아제 (ALDH)에 의해 아세트산으로 변하고, 이는 마지막으로 탄산가스와 물이 되어 탄산 가스는 폐에서, 그리고 물은 신장에서 배설된다.Alcohol is acetaldehyde in the body by alcohol dehydrogenase (ADH), which in turn is converted to acetic acid by aldehyde dehydrogenase (ALDH), which finally becomes carbon dioxide and water, And water is excreted in the kidneys.
ADH는 보통 사람의 체내에 항상 존재하고 있다. 그러나, ALDH1및 ALDH2의 두가지 형태가 존재하는 ALDH의 경우, ALDH2는 보통사람 대부분이 가지고 있지만, ALDH1은 민족에 따라 다르며, 동양인의 경우 약 50%, 한국인의 경우, 약 35%가 결핍되어 있다. 따라서, 한국인의 경우, 에탄올의 직접 작용에 의한 것 뿐만 아니라 아세트알데히드의 작용에 의한 음주시 나타나는 아세트알데히드 증후군, 예를 들어 얼굴 또는 신체가 붉어지거나 구토, 두통 등에 의해서도 고통을 받고 있는 것으로 알려져 있다.ADH is always present in the human body. However, in the case of ALDH in which two forms of ALDH 1 and ALDH 2 exist, ALDH 2 is usually owned by most people, but ALDH 1 varies by ethnic group, about 50% in Asians and about 35% in Koreans. It is deficient. Therefore, Koreans are known to suffer from acetaldehyde syndrome, such as redness of the face or body, vomiting, headache, etc., not only by the direct action of ethanol but also by the action of acetaldehyde.
알코올이 간장에 해를 주는 원인을 살펴보면 ADH가 에탄올을 아세트알데히드로 바꿀 때, NAD+를 사용하여 NADH가 많이 생기고 이것이 다른 물질의 대사에 영향을 미쳐서 지방산 대사를 저하시켜 지방이 간장에 축적되는데 이것이 지방간이다. 아세트알데히드는 간세포 중의 미토콘드리아 등의 세포 소기관에 장해를 주고, 알코올 대사의 항진이 원인이 되어 저산소 상태를 초래한다. 또한, 알코올 자체가 간세포의 세포막 장해를 일으킨다.If you look at the causes of alcohol damage to the liver, when ADH converts ethanol to acetaldehyde, NAD + is used to produce a lot of NADH, which affects the metabolism of other substances, lowers fatty acid metabolism, and fat accumulates in the liver. Fatty liver. Acetaldehyde impairs organelles such as mitochondria in hepatocytes, and is caused by hyperactivity of alcohol metabolism, resulting in a hypoxic state. In addition, alcohol itself causes cell membrane failure of hepatocytes.
따라서, 알코올 섭취로 인한 숙취를 제거하고 혈중 알코올 농도를 감소시킬 수 있는 제제의 연구가 활발히 행하여졌다.Therefore, studies have been actively conducted on preparations that can eliminate hangovers caused by alcohol intake and reduce blood alcohol concentrations.
그러나, 전통적인 갈화를 이용한 숙취제거제, 예를 들어 갈화, 연화청피, 목향, 귤피, 인삼, 저령, 백복령, 신국, 택사, 건조생강, 백출, 백두구인, 사인 등을 함유하는 처방은 복용 방법에 있어서, 달여서 복용하거나, 환제 또는 산제로 만들어 복용해야 하는 불편함이 있었으며, 숙취 제거 효과 또한 그다지 우수하지 못하였고, 종래의 다른 갈화 함유 숙취 제거제의 경우에도 그 효과가 원하는 만큼 우수하지 못하였으며, 콩나물을 주원료로 한 식물 추출물을 함유한 제품이나 미배아와 대두추출물을 함유한 제품의 경우에는 안정성 면에서 여전히 해결해야 할 많은 문제점이 지적되었고, 인공 제제 또는 생약제제를 단독으로 또는 혼합하여 제조한 다수의 드링크제 중 일부 드링크제, 특히 인공 제제는 음용시에 두통, 복통, 구토 등의 부작용을 유발하는 문제점이 있었다.However, a prescription containing a hangover remover using conventional browning, for example, browning, softening skin, Mokyang, tangerine, ginseng, spirit, Baekbokyeong, Shinguk, Taeksa, dried ginger, Baekchul, Baekdu-in, and sign, etc. There was a discomfort to be taken by month, or made of pills or powder, and the hangover removal effect was not very good, and the other effect of the hanger remover containing conventional browning was not as good as desired. In the case of products containing a plant extract as a main ingredient or products containing embryos and soy extracts, many problems still need to be solved in terms of stability, and many of the artificial or herbal preparations prepared alone or in combination Some of the drinks, especially artificial ones, cause side effects such as headaches, abdominal pain and vomiting during drinking. The dots were.
본 발명자들은 상기한 종래의 문제점을 해결하기 위하여 예의연구를 거듭한 결과, 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린 및 울금 추출물을 주성분으로 함유하는 제제가 간기능 회복, 숙취 제거에 우수한 효과를 나타내며, 복용이 편리하고 안정성이 우수한 음료임을 밝혀내어 본 발명을 완성하기에 이르렀다.The present inventors have conducted extensive research to solve the above-mentioned conventional problems, the formulation containing the browning extract, thistle seed extract, taurine and turmeric extract as the main component shows an excellent effect on liver function recovery, hangover removal, The present invention has been found to be a convenient and stable drink to take.
따라서, 본 발명의 목적은 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린 및울금 추출물을 주성분으로 하는 숙취 제거용 음료, 및 그의 제조 방법을 제공하는 것이다.Accordingly, it is an object of the present invention to provide a hangover removal beverage containing a browning extract, a large thistle seed extract, a taurine and turmeric extract as a main component, and a manufacturing method thereof.
본 발명의 다른 목적은 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린 및 울금 추출물 외에도, 감초 매실, 대추, 구기자 및 영지 등으로 구성된 군으로부터 선택되는 하나 이상의 생약 제제, 과일즙, 야채즙, 설탕, 과당 및 꿀로 구성된 군으로부터 선택되는 당류, 수용성 비타민, 구연산 및 로얄 제리 중 하나 이상을 더 포함하는 숙취 제거용 음료, 및 그의 제조 방법을 제공하는 것이다.Another object of the present invention is one or more herbal preparations, fruit juice, vegetable juice, sugar, fructose, and the like, which are selected from the group consisting of licorice plum, jujube, wolfberry and ganoderma To provide a hangover removal beverage, and a method for producing the hangover further comprises one or more of sugars, water-soluble vitamins, citric acid and royal jelly selected from the group consisting of honey.
본 발명자들은 이러한 본 발명의 목적을 달성하기 위하여, 먼저 갈화추출물은 건조된 갈화를 한국 특허 출원 제95-15493호에 기재되어 있는 것과 같은 통상의 방법으로, 즉 갈화 무게의 5 내지 10배의 물을 사용하여 1시간정도 열수 추출한 것을 본 발명의 음료의 갈화 원료로 사용하였다. 그러나, 본 발명에서는 갈화의 열수 추출물을 사용하거나, 1차 열수 추출하고, 2차로 알코올로 추출함으로써 수용성 물질과 알코올 용해성 성분을 모두 추출한 갈화 추출물을 사용하는 것도 가능하다.In order to achieve the object of the present invention, the present inventors, first, the browning extract is dried in the usual way, as described in Korean Patent Application No. 95-15493, that is, water of 5 to 10 times the weight of browning. The hot water extracted for about 1 hour using was used as the raw material for the grinding of the beverage of the present invention. However, in the present invention, it is also possible to use a galvanic extract obtained by extracting both a water-soluble substance and an alcohol-soluble component by using a hydrothermal extract of gallium, or by extracting primary hydrothermal and secondaryly extracting with alcohol.
본 발명의 숙취 제거용 음료의 주요 구성 성분 중 하나인 갈화에는 로비닌, 게니스테인, 이소플라본, 다이드제인, 쿠에르세틴 등의 플라보노이드와 정유성분 및 안식향산, 프로피온산, 쿠마르산 등이 포함되어 있는데, 이중 로비닌은 이뇨 작용과 혈중 잔여 질소 함량 감소 효과를 가져 주독 해독 작용과 주로 관계가 있는 것으로 알려져 있으며, 다이드제인은 편두통, 고혈압, 협심증 등 여러 가지 심장의 대상기능 부전증에 작용하는 것으로 알려져 있다. 또한, 갈화 추출물을 사용하여독성 시험을 실시한 결과, 이의 LD50은 9000 mg/kg 이상으로 안전한 것임이 한국 특허 출원 제95-15493호에 기재되어 있다.Gallium, which is one of the main constituents of the beverage for removing hangover of the present invention, includes flavonoids such as vininine, genistein, isoflavone, dydzein, quercetin, essential oils, benzoic acid, propionic acid, and coumaric acid. Of these, rovinin is known to have a diuretic effect and a decrease in the residual nitrogen content in blood, and is mainly related to detoxification, and dyedzein is known to act on various heart failures such as migraine, hypertension and angina. have. In addition, as a result of the toxicity test using the gallium extract, it is described in Korean Patent Application No. 95-15493 that its LD 50 is safe to 9000 mg / kg or more.
큰엉겅퀴(Milk thistle) 종자 추출물은 큰엉겅퀴 종자로부터 통상의 방법으로 추출한 것을 사용하거나, 상기 종자 추출물을 농축, 정제, 건조시켜 종자 추출물의 유효 성분인 실리마린 (Silymarin) 함량을 70% 정도까지 높은 정제 건조 추출물, 예를 들어 독일의 마다우스사의 의약품 Legalon 등의 원료를 사용할 수 있다.Milk thistle seed extract may be extracted from conventional thistle seeds by conventional methods, or may be concentrated, purified, and dried to obtain a high content of Silymarin, an active ingredient of the seed extract, up to 70%. Raw materials, such as a dry extract, for example, the drug Legalon of Madaus Germany, can be used.
큰엉겅퀴는 남유럽,소아시아,북아프리카 원산의 국화과 식물로 북남미, 호주남부,중앙유럽,중앙 및 동아시아 등지에도 분포되어 있다. 큰엉겅퀴는 1-2년생 초본식물로서 성장하면 높이가 1m 전후가 된다. 학명은 Silybum marianum(L) Gaertn이며, 영문명은 Milk Thistle, Mary Thistle, Lady's Thistle, Holly Thistle 등으로 불리운다.Milk thistle is a plant native to Southern Europe, Asia Minor and North Africa. It is also distributed in North and South America, South Australia, Central Europe, Central and East Asia. Thistle is a 1-2 year old herbaceous plant that grows to around 1m in height. The scientific name is Silybum marianum (L) Gaertn, and the English names are Milk Thistle, Mary Thistle, Lady's Thistle, Holly Thistle, and so on.
큰엉겅퀴의 종자는 2000년 이상 전부터 유럽에서 민간약으로 간장, 담낭, 소화관, 비장 등의 질환 등에 폭넓게 이용되어 왔던 약용 식물로서, 독일에서는 상기한 바와 같은 Legalon 등이 중독에 의한 간장해의 치료약과 만성간염 및 간경변의 보조적 치료약으로써 인가되어 있으며, 미국, 일본 등에서도 그의 간기능 개선 효과로 인하여 상기 큰엉겅퀴 종자 이용 상품이 다수 발매되고 있다.Thistle seed is a medicinal plant that has been widely used in Europe for over 2000 years as a folk medicine for diseases such as liver, gallbladder, digestive tract, spleen, etc. It is approved as an adjuvant therapeutic drug for hepatitis and cirrhosis, and many of these large thistle seed-use products have been released in the United States and Japan due to its effect on improving liver function.
큰엉겅퀴의 종자 추출물의 유효성분은 이성질체인 실리빈(Silybin), 실리디아닌(Silydianin), 실리크리스틴(Silychristin) 등의 플라보노리그난 (Flavonolignan) 으로서, 이러한 플라보노리그난은 통상 실리마린으로 통칭되는데,실리마린 중에서도 실리빈이 가장 생체 활성이 높은 성분으로 알려져 있으며, 실리마린은 큰엉겅퀴 종자 중에 1.5 내지 3%의 함량으로 함유되어 있다. 실리마린은 간의 세포막을 직접 또는 간접적으로 안정화시켜 유해물이 간세포로 들어가는 것을 차단함으로써 간의 해독 능력을 증강시키고, 정상 간세포의 재생을 촉진하여 간기능을 개선시키는데, 이는 많은 임상 실험에 의해 확인되었으며, 알코올성 간장 상해, 약물에 의한 간장 상해, 간경변을 비롯하여 여러 종류의 간장질환에 유효한 것으로 알려져 있다. 실리마린의 급성 독성에 대해서는 여러 종류의 동물에서 조사되었는데, 마우스에서는 20 g/kg, 개에서는 1 g/kg의 경구 투여에 의해 전혀 부작용이 없었으며, 실리빈의 정주 투여에서의 LD50은 마우스에서 1010 mg/kg, 래트에서 873 mg/kg, 토끼에서 300 mg/kg이었고, 실리마린을 래트에 1 g/kg으로 15일간 경구투여하였으나 부작용은 없었으며, 또한 래트에 실리마린을 1000 mg/kg/일 의 투여량으로 16 내지 22주간 장기 경구투여하였으나 부작용은 없었고, 임신 래트, 토끼에서 태아에의 영향도 전혀 관찰되지 않아 장기적으로 다량 섭취하여도 안전함이 알려져 있다.The active ingredient of thistle seed extract is the flavonolignans such as the isomers Silybin, Silydianin, and Silychristin, which are commonly referred to as silymarins. Among the silymarins, silybin is known as the most bioactive component, and silymarin is contained in the content of 1.5 to 3% in thistle seeds. Silymarin stabilizes liver cell membranes directly or indirectly, blocking harmful substances from entering the hepatocytes, enhancing liver detoxification, and promoting regeneration of normal hepatocytes, improving liver function, which has been confirmed by many clinical trials. It is known to be effective against various types of hepatic diseases, including injury, drug-induced liver injury and cirrhosis. For the acute toxicity of silymarin was investigated in different types of animals, mice in the 20 g / kg, more in 1 g / had never had the side effect by oral administration of kg, LD 50 in the silica blank intravenous administration in mice 1010 mg / kg, 873 mg / kg in rats and 300 mg / kg in rabbits. Silymarin was orally administered to rats at 1 g / kg for 15 days with no side effects, and rats were also given 1000 mg / kg / day Long-term oral administration of 16 to 22 weeks at the dose of no side effects, and no effects on the fetus in pregnant rats, rabbits are not observed at all is safe even in the long term.
한편, 아미노산의 일종인 타우린은 담즙의 생성을 촉진하여 간에 쌓인 노폐물 배설을 촉진시킴으로써 간기능 개선효과를 나타내는데, 종래의 연구 결과에 의하면, 동양인에게서 쉽게 나타나는 아세트알데히드 증후군을 감소시키며 각종 간질환, 예를 들어 만성간염, 지방간, 간경변 등에도 유효하고, 알코올 금단 증상 치료에도 유효한 것으로 입증되었다. 또한 타우린은 독성이 없는 안전한 물질임이 알려져 있다.On the other hand, taurine, which is a kind of amino acid, promotes bile production and promotes the excretion of waste accumulated in the liver, and shows the effect of improving liver function. According to the conventional research results, it is possible to reduce acetaldehyde syndrome, which is easily seen in Asians, and various liver diseases, eg For example, it has been proved effective for chronic hepatitis, fatty liver, cirrhosis, etc., and for the treatment of alcohol withdrawal symptoms. It is also known that taurine is a safe, nontoxic material.
울금 추출물은 통상의 방법으로 추출한 것을 사용할 수 있다. 울금은 학명이 Curcuma aromatica Salisb이며, 울금은 봄우콘이라고도 불리운다. 우콘은 생강과에 속하는 다년초로 고온다습한 지역에서 자생하며 현재 열대에서 아열대를 중심으로 광범위한 지역에 분포하고 있다. 울금 추출물 중 쿠쿠민 (Curcumin)은 간기능 강화 작용, 담즙의 분비를 촉진하는 이담작용과 이뇨작용, 살균, 항균 작용, 항염증 작용, 항콜레스테롤 작용 등을 가지는데, 특유의 황색을 띠어 색소의 기능도 한다.Turmeric extract can be used to extract the conventional method. Turmeric is the scientific name Curcuma aromatica Salisb, and turmeric is also called Bomb Ukon. Ukon is a perennial herb belonging to the Gingeraceae family, which grows in hot and humid regions, and is currently distributed in a wide range of regions from the tropics to the subtropics. Curcumin of turmeric extract has the effect of strengthening liver function, diarrhea, diuretic, bactericidal, antibacterial, anti-inflammatory, and anti-cholesterol, which promote the secretion of bile. It also functions.
갈화 추출물의 경우, 그의 함량이 음료 100 ml를 기준으로 1 내지 30 ml, 특히 5 내지 15 ml가 바람직하며, 큰엉겅퀴 종자 추출물은 실리마린의 함량이 140 내지 500 mg, 특히 210 내지 420 mg이 되도록 하는 것이 바람직하고, 타우린은 0.1 내지 3.5 g, 특히 0.5 내지 3 g이 바람직하고, 울금 추출물은 쿠쿠민의 함량이 400 내지 600 mg이 되게 하는 것이 바람직하다.In the case of a gallium extract, the content thereof is preferably 1 to 30 ml, particularly 5 to 15 ml, based on 100 ml of the beverage, and the milk thistle seed extract is such that the content of silymarin is 140 to 500 mg, especially 210 to 420 mg. Preferably, the taurine is preferably from 0.1 to 3.5 g, in particular from 0.5 to 3 g, and the turmeric extract is such that the content of coocumin is from 400 to 600 mg.
본 발명의 음료는 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린, 및 울금 추출물을 주성분으로 하여 인체 대사에 활성이 있는 전통 한방 소재인 감초, 대추, 매실, 구기자, 영지, 꿀 등에서 선택된 하나 이상의 성분과, 필요에 따라 시원한 맛과 산미를 줄 수 있는 배과즙, 사과즙 및 구연산, 그리고 알코올 대사시 소모되기 쉬운 비타민류를 보강하기 위한 비타민 B1, B2, B6, C 및 로얄제리를 추가로 함유할 수 있다.The beverage of the present invention comprises one or more components selected from licorice, jujube, plum, wolfberry, ganoderma lucidum, honey, etc., which are traditional herbal materials active in human metabolism, mainly composed of gallium extract, thistle seed extract, taurine, and turmeric extract, If necessary, it may contain pear juice, apple juice and citric acid, which can give a cool taste and acidity, and vitamin B 1 , B 2 , B 6 , C and royal jelly to reinforce vitamins that are easily consumed in alcohol metabolism. Can be.
감초 추출물의 양은 음료 100 ml를 기준으로 0.5 내지 3.0 ml가 바람직한 것으로 나타났으며, 매실 추출물의 양은 0.1 내지 3.0 ml의 함량일 때 그 신맛과 신선한 향미가 좋은 것으로 나타났다. 영지는 그의 쓴 맛 때문에 음료 100 ml를 기준으로 그 함량이 3.0 ml을 넘지 않도록 하는 것이 바람직하며, 배즙, 사과즙, 레몬 에센스 등의 과즙은 음료에 신선한 느낌을 더하여 주기 위해 첨가하며 과즙은 15 ml 이하의 범위 내에서 포함되는 것이 바람직하다. 알코올 대사시 소모되기 쉬운 비타민류를 보강하기 위해 본 발명의 음료에 비타민 B1, B2, B6, 비타민 C 등의 비타민이 첨가될 수 있으며, 그 양은 음료 100 ml를 기준으로 0.2 ml 이하로 제한하는 것이 바람직하다.The amount of licorice extract was found to be preferably 0.5 to 3.0 ml based on 100 ml of beverage, and the sour and fresh flavor was good when the amount of plum extract was 0.1 to 3.0 ml. The ganoderma lucidum may not be more than 3.0 ml based on 100 ml of drink because of its bitter taste. Juices such as pear juice, apple juice and lemon essence are added to add freshness to the beverage. It is preferable to be included in the range of. Vitamin B 1 , B 2 , B 6 , vitamin C, etc. may be added to the beverage of the present invention to reinforce vitamins that are easily consumed during alcohol metabolism, and the amount thereof may be 0.2 ml or less based on 100 ml of beverage. It is desirable to limit.
예를 들어 음료 100 ml를 기준으로 배즙은 0.5 내지 8.0 ml, 사과즙은 0.5 내지 7.0, 꿀은 0.5 내지 5.0ml, 과당은 5.0 내지 15.0ml, 비타민 B1은 0.001 내지 0.01ml, 비타민 B2는 0.001 내지 0.01ml, 비타민 B6는 0.001 내지 0.01ml, 비타민 C 는 0.001 내지 0.05ml, 구연산은 0.1 내지 0.5ml, 로얄제리는 0.005 내지 0.05ml인 것이 바람직할 수 있다.For example, based on 100 ml of beverage, 0.5 to 8.0 ml of pear juice, 0.5 to 7.0 apple juice, 0.5 to 5.0 ml of honey, 5.0 to 15.0 ml of fructose, 0.001 to 0.01 ml of vitamin B 1 , and 0.001 of vitamin B 2 To 0.01 ml, vitamin B 6 is 0.001 to 0.01 ml, vitamin C is 0.001 to 0.05 ml, citric acid is 0.1 to 0.5 ml, royal jelly may be preferably 0.005 to 0.05 ml.
상기의 성분 외에도, 본 발명의 음료에는 통상의 음료에 사용되는 각종 재료 및 향료, 방부제, 보존제 등이 적정량으로 포함될 수 있다.In addition to the above components, the beverage of the present invention may contain various materials and flavors, preservatives, preservatives and the like used in conventional beverages in an appropriate amount.
이하, 본 발명에 따른 숙취제거용 음료의 제법을 실시예를 참조로 기술할 것이지만, 본 발명은 이들 실시예에 의해 제한되는 것은 결코 아니다.Hereinafter, the preparation method of the hangover drink according to the present invention will be described with reference to Examples, but the present invention is not limited by these Examples.
(실시예)(Example)
통상의 방법으로 추출한 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린 및 울금 추출물과, 정제수를 표 1의 조성이 되도록 혼합 탱크에 넣고, 이를 50℃로 가온하여 배합물들이 완전히 용해되도록 충분히 교반하였다.The brownish extract, thistle seed extract, taurine and turmeric extract extracted by a conventional method and purified water were put in a mixing tank so as to have the composition of Table 1, which was heated to 50 ° C. and sufficiently stirred so that the formulations were completely dissolved.
배합이 완료되면 다시 침전물이나 부유물을 제거하기 위하여 5 μm 필터 및 0.45 μm 이하의 정밀 여과장치를 사용한 한외여과 장치에서 청징하게 여과하였다.Upon completion of the formulation, the filtration was clarified in an ultrafiltration apparatus using a 5 μm filter and a microfiltration device of 0.45 μm or less in order to remove precipitates or suspended solids.
수득된 청징물을 열교환기를 통하여 80℃에서 30초 내지 90초간 가열한 상태에서 적정 유리병 용기에 주입하여 즉시 밀봉하였다.The obtained clarifier was injected into a suitable glass bottle container immediately after being heated at 80 ° C. for 30 seconds to 90 seconds through a heat exchanger, and was immediately sealed.
상기 살균된 병조림물을 40℃가 될 때까지 냉각시켜 실시예 1의 음료를 얻었다.The sterilized jars were cooled to 40 ° C. to obtain the beverage of Example 1.
한편, 보조 성분인 감초, 매실, 대추, 구기자 추출물, 영지 추출물 등의 기타 첨가 성분은 마쇄하여 착즙 후 저온에서 감압 농축시키고 이어서 천연향을 첨가한 다음 배즙, 사과즙 등과 기타 성분 및 정제수를 하기의 조성이 되도록 혼합 탱크에 넣은 후 상기 실시예 1의 조성물에 혼합한 후 실시예 1과 동일하게 제조하여 실시예 2의 음료를 얻었다.Meanwhile, other additives such as licorice, plum, jujube, goji berry extract, and ganoderma lucidum, which are auxiliary components, are ground and concentrated under reduced pressure after juice extraction, and then natural flavors are added, followed by pear juice, apple juice, and other ingredients and purified water. It was put in a mixing tank so as to mix with the composition of Example 1 and then prepared in the same manner as in Example 1 to obtain a beverage of Example 2.
실시예 3 및 4의 음료도 상기와 유사하게 제조하였다.The beverages of Examples 3 and 4 were prepared similarly to the above.
비교예 1Comparative Example 1
본 출원인의 한국 특허 출원 번호 제95-15493호의 실시예 1에 기재되어 있는, 갈화를 주성분으로 하며, 감초, 매실, 대추, 등의 성분을 추가로 함유하는 음료를 비교예1로 사용하였다.The beverage described in Example 1 of the applicant's Korean Patent Application No. 95-15493 as a main component and further containing components such as licorice, plum, jujube, and the like was used as Comparative Example 1.
효과 시험Effect test
상기 수득된 실시예 1 내지 4와, 비교예 1의 음료를 동물에 투여하여 다음과 같은 방법으로 본 발명의 음료가 실험 동물의 에탄올 대사에 미치는 영향을 실험하였다.The effects of the beverage of the present invention on the ethanol metabolism of the experimental animals were tested in the following manner by administering the obtained Examples 1 to 4 and the beverage of Comparative Example 1 to the animals.
실험 동물: 3주령 스프라그-돌리 흰 쥐를 사용하였다. 실험 동물을 3주 동안 사육실 환경에 적응시킨 후 실험에 사용하였다. 사육 및 실험 기간 동안의 온도는 24 내지 26℃를 유지하였고, 흰쥐용 케이지에 2 내지 5마리씩 넣어 사육하였다.Experimental Animals: Three week old Sprague-Dawley rats were used. The experimental animals were used for the experiment after adapting to the nursery environment for 3 weeks. During the breeding and experiment period, the temperature was maintained at 24 to 26 ° C, and 2 to 5 animals were raised in a cage for rats.
사료 및 음용수: 사료는 자유로이 섭취하도록 급이하였고, 음료수는 증류수를 사용하였다.Feed and drinking water: Feed was fed freely and distilled water was used.
실험 방법: 음용수만 제공하고 24시간 절식시킨 흰 쥐의 위장에 실시예 1 내지 4 및 비교예 1의 음료와, 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린, 및 울금 추출물을 함유하지 않은 것을 제외하고는 실시예 2와 동일한 성분을 갖는 음료 (대조군 1)를 각각 스테인레스 스틸 존데(10cm)를 통하여 1.67 ml/kg의 양으로 투여하고, 대조군 2에는 식염수만을 투여하였다. 상기 투여 10분 후에 에탄올 2.0 ml/kg을 투여하였다. 각 군은 5 내지 6마리의 동물로 실험하였다. 에탄올 투여 1시간 후에 경구 탈추법으로 희생시킨 실험동물을 해부하여 뇌와 간을 적출하였다. 뇌와 간은 무게를 측정한 후 인산완충 생리 식염수 (Krebs original Ringer Phosphate)를 0.5 ml/g 조직 무게로 처리하고 4℃ 이하에서 다루었다. 뇌와 간은 조직 호모게나이저 (Biospec Products사, Model M133/1281-0)로 균질화한 후 180 μl를 에펜도르프 튜브에 옮기고 0.5 ml의 메틸렌 클로라이드를 가한 후 와동 혼합기로 격렬하게 교반하였다. 이를 소량의 무수 황산 마그네슘으로 처리하여 수분을 제거하고 다시 교반한 후 얼음물에 보관하면서 GC-FID (Hewlet Packard HP5890; 컬럼, HP-1, 30 m, φ=0.53 mm)로 분석하였다. 에탄올의 양은 에틸 아세테이트와 에탄올 사이의 표준 곡선에서 얻은 회귀직선식과 내부 표준으로 사용한 에틸 아세테이트를 기준으로 계산하였다.Experimental Methods: Except for the beverages of Examples 1 to 4 and Comparative Example 1, which contained drinking water only and fasted for 24 hours, did not contain the beverages of Examples 1 to 4 and Comparative Example 1, and browned extract, thistle seed extract, taurine, and turmeric extract. Drinks having the same ingredients as in Example 2 (Control 1) were each administered in an amount of 1.67 ml / kg via stainless steel sonde (10 cm), and control group 2 was administered only saline. Ten minutes after the administration, 2.0 ml / kg of ethanol was administered. Each group was tested with 5 to 6 animals. One hour after the administration of ethanol, the experimental animals sacrificed by oral extraction were dissected to extract brains and livers. Brain and liver were weighed and treated with Krebs original Ringer Phosphate at 0.5 ml / g tissue weight and treated below 4 ° C. The brain and liver were homogenized with a tissue homogenizer (Biospec Products, Model M133 / 1281-0), then 180 μl were transferred to an Eppendorf tube, 0.5 ml of methylene chloride was added, and vigorously stirred with a vortex mixer. It was analyzed by GC-FID (Hewlet Packard HP5890; column, HP-1, 30 m, φ = 0.53 mm) while treating with a small amount of anhydrous magnesium sulfate to remove moisture, stirring and storing in ice water. The amount of ethanol was calculated based on the regression line obtained from the standard curve between ethyl acetate and ethanol and ethyl acetate used as internal standard.
결과:result:
이상의 결과에서 알 수 있는 바와 같이, 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린, 및 울금 추출물을 동시에 함유하는 음료 (실시예 1 및 실시예 2)를 동물에 투여한 경우에, 종래의 갈화 추출물 함유 음료 (비교예 1)와 비교하여 알코올 음용 1시간 후 알코올 대사가 현저히 촉진되었음을 알 수 있었다. 또한, 갈화 및 큰엉겅퀴 종자 추출물 (실시예 3), 그리고 갈화 및 타우린 (실시예 4)을 함유하는 음료의 경우에는 비교예 1의 음료와 거의 유사한 수준의 알코올 대사 촉진 활성을 가짐이 밝혀졌다. 따라서, 본 발명의 음료의 주 성분인 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린 등은 서로 상승 효과를 가짐을 알 수 있다.As can be seen from the above results, when a beverage (Examples 1 and 2) containing simultaneously the browning extract, thistle seed extract, taurine, and turmeric extract is administered to the animal, the conventional browning extract-containing beverage Compared with (Comparative Example 1), it was found that alcohol metabolism was significantly promoted after 1 hour of alcohol consumption. In addition, it was found that the beverage containing the browned and large thistle seed extract (Example 3), and the browned and taurine (Example 4) had an almost similar level of alcohol metabolism promoting activity as the beverage of Comparative Example 1. Therefore, it can be seen that the main components of the beverage of the present invention, such as browning extract, thistle seed extract, taurine and the like have a synergistic effect with each other.
저장 실험Storage experiment
상기 실시예 2에 준하여 제조한 음료를 40℃ 항온기에 4주일 동안 저장하면서 매주 제품의 외관상의 변화 및 관능적 변패 여부를 조사한 결과, 품질의 변화가전혀 나타나지 않았다.When the beverage prepared according to Example 2 was stored for 4 weeks in a 40 ° C. constant temperature thermostat, the results of the weekly changes in appearance and sensory deterioration of the product were not found.
이상에서 상술한 바와 같이, 갈화 추출물, 큰엉겅퀴 종자 추출물, 타우린, 및 울금 추출물을 동시에 함유하는 본 발명에 따른 음료는, 복용시의 불편의 문제점이 없고, 체내에서 보다 흡수가 빠르며, 숙취 제거 효과가 탁월하고, 음용시 기호성에 있어서 만족도가 높으며, 안정성도 우수하다.As described above, the beverage according to the present invention simultaneously containing the browning extract, thistle seed extract, taurine, and turmeric extract, there is no problem of discomfort when taking, faster absorption in the body, hangover removal effect Excellent, satisfactory in palatability when drinking, and excellent in stability.
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WO2016195268A1 (en) * | 2015-06-03 | 2016-12-08 | 주식회사 한생바이오 | Hangover relief beverage composition containing peanut sprout extract, and preparation method therefor |
IT201700042325A1 (en) * | 2017-04-18 | 2018-10-18 | Ecillax S R L | USEFUL COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS RELATED TO THE ABUSE OF ALCOHOLIC |
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JP4609875B2 (en) * | 2001-07-31 | 2011-01-12 | 有限会社大長企画 | healthy food |
KR100430916B1 (en) * | 2001-08-25 | 2004-05-10 | 권영훈 | Functional drink and method thereof |
KR100706465B1 (en) * | 2005-01-26 | 2007-04-10 | 주식회사 태영이앤티 | cocktail for hangover remedy |
KR100802904B1 (en) * | 2006-12-14 | 2008-02-13 | 주식회사오뚜기 | Method of manufacturing beverage containing curcuma longa l |
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KR102136053B1 (en) * | 2018-07-05 | 2020-07-22 | 내츄럴헬스케어 주식회사 | Composition for Removing Hangover Comprising Herb Extract and Beverage Thereof |
KR102661369B1 (en) * | 2021-10-26 | 2024-04-25 | 재단법인 경남항노화연구원 | A functional food composition for preventing and relieving hangover enriched with steamed and lyophilized mature silkworm |
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WO2016195268A1 (en) * | 2015-06-03 | 2016-12-08 | 주식회사 한생바이오 | Hangover relief beverage composition containing peanut sprout extract, and preparation method therefor |
IT201700042325A1 (en) * | 2017-04-18 | 2018-10-18 | Ecillax S R L | USEFUL COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS RELATED TO THE ABUSE OF ALCOHOLIC |
EP3391895A1 (en) | 2017-04-18 | 2018-10-24 | Ecillax S.r.l. | Compositions useful for the treatment of symptoms associated with alcohol abuse |
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