KR101210748B1 - Composition comprising the extract of Acanthopanax sessiliflorus and green tea for treating or alleviating hangover syndrome - Google Patents

Abstract

The present invention relates to a composition for hangover relief and liver protection, which contains the extract of Ogapi and green tea as an active ingredient, since the ogapi and green tea extract of the present invention have excellent side effects of alcohol and liver protection without any side effects on the human body, The composition containing this as an active ingredient can be usefully used as a medicine and health functional food for hangover relief and liver protection.

Ogapi, green tea, hangover relief, soy sauce protection, dietary supplement, medicine

Description

Composition comprising the extract of Acanthopanax sessiliflorus and green tea for treating or alleviating hangover syndrome}             

1 is a diagram showing the comparison of the blood alcohol concentration by oral administration of alcohol and blood after 1 hour after oral administration of the Ogapi extract, green tea extract, and a mixed extract thereof to mice,

2 is a diagram showing a comparison of blood alcohol concentrations of blood collected after oral administration of alcohol after 1 hour after oral administration to the mice of the hangover composition and commercially available products using the Ogapi extract and the green tea extract. .

The present invention relates to a composition for relieving hangovers and soy sauce protection, which contains the extracts of Ogapi and green tea as active ingredients, and more specifically, contains 2-40% by weight of the extract and 2-40% by weight of green tea extract. It relates to a composition characterized by.

 Alcohol has not only been manufactured and consumed in human society for a long time, but it is also manufactured and sold in almost every country except the Islamic religion.

According to a survey conducted by the Samsung Hospital for 1,600 people, the drinking habits of the workplace and health awareness of the liver showed that 87.1% of the alcoholic beverages of Koreans in their 20s and 50s were 1 to 3 times a week. In terms of health, it is quite worrying.

As such, modern people consume excessive amounts of alcohol so much that they cannot digest it, causing side effects such as thirst, general boredom, fatigue, memory loss, bloating, indigestion, vomiting, diarrhea and vitamin deficiency. Many people suffer from the phenomenon, and the risk of alcoholism increases.

Normal alcohol metabolism is ingested by alcohols (ethyl alcohol, methyl alcohol, ethylene glycol, etc.), absorbed from the stomach or small intestine, 10% of which is excreted by breathing, sweating, urine, etc. Enters into blood vessels and is metabolized in the liver (M. Nakanishi; Saishin Igaku , 31 , p2086, 1976). Subsequently, alcohol dehydrogenase (ADH) present in hepatocytes oxidizes alcohol to acetaldehyde, and acetaldehyde is decomposed into acetic acid by acetaldehyde dehydrogenase in hepatocytes and transferred to muscle or adipose tissue throughout the body. Finally, it is decomposed into carbon dioxide gas and water. However, if the alcohol metabolism is abnormal due to excessive drinking during such decomposition metabolism process, most of the patients suffer from hangovers such as heavy, painful, or sore throat due to un metabolized ethyl alcohol or acetaldehyde. .

As part of the research on this phenomenon, compositions using choline acids, which are widely used as gallstone solubilizers, have been developed and marketed. These choline acids have an effect of edema, hepatic detoxification, hepatic blood flow improvement, fat absorption and fine action. Ursodeoxycholic acid, which is known to be effective in improving the liver function of chronic liver disease, systemic malaise due to hepatic dysfunction, indigestion, anorexia, physical fatigue due to biliary excretion, It is marketed as a gallstone dissolving agent, and is effective in treating fatty liver, and when administered orally, improvement of liver function and reduction of liver fat mass have been reported (Japanese Patent Laid-Open Publication No. 4-235918) Taurorusodeoxycholic acid ), And commercially available cheodeoxycholic acid and dehydrocholic acid as gallstone dissolving agents. .

However, the composition using choline acids is effective in general symptoms caused by stress such as increase of adrenal weight by stress and prevention of spleen atrophy, suppression of ascorbic acid content change of adrenal gland and suppression of blood biochemical changes. It has only been proven and there is no mention of a hangover-protective effect on the liver.

In addition, as an herbal preparation, hangover and liver function are improved by using extracts obtained by differently blending persimmon peel, buttercup, ginjin, Schisandra chinensis, mung bean, sauerkraut, chestnut and licorice into one or two or more ingredients. Is a unique blended food, "Hangover elimination and liver function improving agent and its manufacturing method (Formula 2002-81995)", "Low alcohol has a liver toxicity and hangover elimination activity isolated from hut dogwood Insoluble Extraction Fractions and Polysaccharide Materials and Compositions Containing the Same (Korean Patent Laid-Open Publication No. 2002-64151), "Hovenodolinol, an active ingredient of the earth fruit, a method for preparing the same and an alcohol decomposer or hangover-containing agent (Korean Patent Publication No. 2002-86963) ", as well as formulations derived from various plants such as rice snow extract (Kurume), alder, oak vinegar liquor, browning and milk thistle extract are effective for hangover. Although it has been reported that, among the various changes caused by drinking, it appears to be effective or ineffective only in some items, and it is difficult to find a big characteristic technique in that it simply uses an extract that has been used as a conventional herbal medicine. In general, the aim is to simply use nutrient tonic or known efficacy.

Therefore, there is an urgent need for the development of new oral hangovers and liver protection, which are effective without any side effects.

Meanwhile, the ogapi used in the present invention is also called an ogalpi, and its scientific name is Acanthopanax sessiliflorus, which is a deciduous shrub belonging to the plant taxonomic genus Araliaceae, and the root bark of the same plant is used for medicinal purposes. It is becoming. Acanthosides B and D (eleutheroside E) of the lignan lineage contained in Ogapi are effective in tonic, carbohydrate and fat metabolism, alcohol detoxification, appetite enhancement, blood circulation, warming, constipation improvement and fatty liver, Acantosides A and C are effective in controlling bone marrow, increasing white blood cells (immunity and resistance), improving allergic diseases, and rapidly recovering after cancer treatment (Yangchangsoo, The Journal of Pharmacy , 40 (3 ), pp251 ~ 261, 1996).

Green tea refers to the leaves of the tea tree ( Thea sinensis L.), also known as tea leaf, and is a shrub belonging to theaceae according to the plant taxonomy. Unlike coffee, green tea does not cause side effects due to caffeine because the ingredients such as polyphenols and vitamins contained in tea leaves are insoluble at low temperatures due to incompatibility with low caffeine. to be. Green tea contains more nitrogen, polyphenols, sugars, organic acids, vitamins and minerals than other beverages. In particular, polyphenols include flavanols, known as catechins. Mostly, it contains alkaloids such as caffeine, theobromine and theophylline. Among them, essential amino acids such as sweet amino acid, glutamic acid and aspartic acid, and sour aroma, and bitter umami arginine are added to add flavor of tea (peroxynitrite and activity of green tea polyphenols). Study on Oxygen Scavenging Activity, Pusan National University, Gye Insook), In particular, polyphenols are sensitized by inhibiting lipid peroxidation in the body and removing active oxygen by synergistic action with antioxidants such as vitamin C, E and β-carotene in green tea. And prevents adult diseases, including cancer.

Accordingly, the present inventors have properly formulated herbal medicines and various active ingredients exhibiting excellent medicinal effects on drinking hangovers, and the composition of the present invention exhibits a wide range of effects on drinking hangovers and protects the liver than conventional hangover drinks. And the present invention was completed by confirming the excellent alcohol metabolism effect.

It is an object of the present invention to provide a hangover-relieving composition and a pharmaceutical or health functional food containing the same as an active ingredient, as well as having a decomposing action and a hepatoprotective effect of alcohol without side effects.

In order to achieve the above object, the present invention provides a composition for relieving hangover and soy sauce, which contains the extract of Ogapi and green tea as an active ingredient.

The composition is characterized in that it comprises 2 to 40% by weight of the extract of Ogapi and 2 to 40% by weight of green tea extract.

In another aspect, the present invention provides a pharmaceutical composition for the hangover and liver protection comprising a composition containing the extract and the green tea extract as an active ingredient.

In addition, the present invention provides a health functional food comprising a composition containing foods and food acceptable food supplements, and the composition containing the extracts of ginseng and green tea as an active ingredient exhibiting a hangover and preventing and improving liver protection.

The dietary supplement includes a form that is a powder, granules, tablets, capsules or beverages, and preferably includes a form of a beverage.

In addition, the health functional food is selected from the group consisting of honey, alanine, aspartic acid, nitrate nitrate, taurine, ascorbic acid, in addition to the composition for the hangover and liver protection containing the extract of the ooga and green tea as an active ingredient Contains more than one component.

Hereinafter, the present invention will be described in detail.

Ogapi and green tea extract of the present invention can be prepared by the following method.

Specifically, after washing to remove foreign substances present on the surface of each of the dried cucumber or green tea, cut into 5 ~ 10cm length, dried or dried in a dryer, and then crushed or used as it is about 5 to 30 times , Preferably 10 to 15 times volume / weight of water, lower alcohols (ethanol, etc.) or a mixed solvent thereof, for 1 to 5 hours, preferably at an extraction temperature of 70 to 120 ° C., preferably 90 to 100 ° C. The supernatant is separated by filtration or centrifugation by hot water extraction for 2 to 3 hours, preferably filtered to obtain the respective herbal extracts, and additionally concentrated or dried to dry powdered cucumber or green tea. Extracts can also be obtained.

After filtering the extract obtained from the extraction step and again adding water or lower alcohol, or a mixed solvent and prepared under the same conditions as above, the extract of the two medicinal herbs in a certain ratio, preferably 1: 0.5 to 2 Formulation in a ratio of to prepare a hangover composition.

The extract stock solution contains 0.01% to 5% solids, and the extract stock solution may be prepared by additionally performing concentrated or reduced pressure drying or lyophilization.

The present invention provides a composition for relieving hangovers and protecting the liver, which contains the extracts of Ogapi and Green Tea extracts obtained by the above-described preparation as an active ingredient.

The oral extract, green tea extract, and the mixture of agar and green tea extract obtained by the above-mentioned method in a ratio of 1: 0.1 to 1:10 were orally administered to the rat, followed by oral administration of alcohol, to determine the blood alcohol concentration of the rat. As a result, it was found that an excellent alcohol degrading effect was observed in the group administered with Ogapi extract, green tea extract, and mixtures thereof compared to the control group, and in the group administered with the mixture of Ogapi and green tea extracts, a significant decrease in alcohol concentration was observed. .

In addition, the ogapi and green tea of the present invention has been used for a long time as an edible and herbal medicine extracts of the present invention extracted therefrom also have no problems such as toxicity and side effects.

The present invention provides a composition for relieving hangovers and protecting the liver containing the extract of Ogapi and green tea as an active ingredient.

In another aspect, the present invention provides a pharmaceutical composition for the hangover and liver protection comprising a composition containing the extract and the green tea extract as an active ingredient.

The pharmaceutical composition of the present invention is prepared in a conventional pharmaceutical formulation by selecting one or two or more pharmaceutically acceptable conventional carriers and one or two or more additives in an effective amount of the composition as a main component.                     

Compositions comprising extracts according to the invention can be used in the form of powders, granules, solutions, tablets, capsules, soft capsules, pills, suspensions, respectively, according to conventional methods, and compositions comprising extracts Carriers, excipients and diluents which may be included in include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose , Microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used.

Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and the solid preparations may include at least one excipient such as starch, calcium carbonate, sucrose or lactose, gelatin, and the like. Mixed preparations may also be used, in addition to simple excipients, lubricants such as magnesium stearate and talc. Liquid preparations for oral use may include various excipients such as wetting agents, sweeteners, fragrances, preservatives, etc., in addition to water and liquid paraffin, which are simple diluents commonly used in suspensions, solutions, emulsions, and syrups. have.

In addition to the above main components, the pharmaceutical composition of the present invention contains minerals such as vitamins B, C, E, beta-carotene, Ca, Mg, and Zn, phospholipids such as lecithin, compounds such as maltol, oligosaccharides, amino acids, and honey as auxiliary components. , Taurine and the like can be used, and the use of a mixture of two or three of them is more preferable because it can increase or enhance the biological activity effect.

Among them, alanine was reported by the Institute of Insecticides, which is used for the treatment of diabetes in herbal medicine or folk medicine. It promotes the secretion of insulin in the human body, lowers blood sugar levels, activates liver function, and alanine is converted into glycogen. It promotes oxidation and is said to have a hepatoprotective effect.

In addition to the above ingredients, in order to enhance the taste as a known additive, natural flavors such as plum, lemon, pineapple or herb, or natural fruit juice, natural pigments such as chlorophyllin, flavonoids, and fructose, sweet sugar Can be mixed with honey, sugar alcohol, sugar and acidulants such as citric acid and sodium citrate.

The amount of the composition of the present invention may vary depending on the age, sex, and weight of the patient, but in general, an amount of 5-100 mg, preferably 5-20 mg, may be optionally orally administered based on an adult body weight of 60 kg. Can be. In addition, the dosage of the composition may be increased or decreased depending on the route of administration, the severity of the disease, sex, weight, age, and the like. Thus, the dosage amounts are not intended to limit the scope of the invention in any manner.

In another aspect, the present invention provides a health functional food comprising a composition containing food extracts and food supplements acceptable as an active ingredient and a green tea extract showing a hangover relief and liver protection prevention and improvement effect.

Examples of the food to which the composition containing the scabies and green tea extracts as an active ingredient can be added, for example, various foods, beverages, gums, teas, vitamin complexes, and health functional foods.

It may also be added to foods or beverages for the purpose of preventing hangovers and protecting the liver. At this time, the amount of the composition in the food or beverage may be added in 0.01 to 15% by weight of the total food weight, the health beverage composition may be added in a ratio of 0.02 to 5g, preferably 0.3 to 1g based on 100ml. .

The health functional beverage composition of the present invention is not particularly limited to other ingredients except for containing the composition as an essential ingredient in the indicated ratios, and may contain various flavors or natural carbohydrates, etc. as additional ingredients, as in general beverages. Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And conventional sugars such as polysaccharides such as dextrin, cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of natural carbohydrates is generally about 1-20 g, preferably about 5-12 g per 100 ml of the composition of the present invention.

In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. The compositions of the present invention may also contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical, but is generally selected in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.

Below, The invention is illustrated in detail by the following examples and experimental examples.

However, the following examples and experimental examples are illustrative of the present invention, and the content of the present invention is not limited by the following examples and experimental examples.

Example 1 Preparation of Ogapi Extract

1-1. Ogapi Water Extract Manufacturer

After cleaning and drying the ogapi (Gyeongdong Market), cut it into 5 ~ 10㎝ lengths, put it in an extractor with a cooler with 5 ~ 30 times the weight of ogapi and extract it at 90 ~ 100 ℃ for 2 ~ 3 hours, and then filter it. The primary extract was obtained. After filtration, water as a primary extraction solvent was further added to the residue, followed by extraction for 1-2 hours to obtain a secondary extract. The extract was concentrated under reduced pressure at 45-100 ° C. and dried to obtain a powdered extract.

1-2. Manufacturing of Ogapi hydrous alcohol extract

After cleaning and drying the dried Ogapi (Kyungdong Market), cut it into 5 ~ 10㎝ lengths and put it in an extractor with a cooler with 70% ethanol of 5 ~ 30 times the weight of Ogapi and extract it for 2 ~ 3 hours at 90 ~ 100 ℃ After filtration to obtain a primary extract. After filtration, 70% ethanol as a primary extraction solvent was further added to the residue, followed by extraction for 1 to 2 hours to obtain a secondary extract, and a mixture of 1 and 2 extracts was used as an extract of Ogapi. The extract was concentrated under reduced pressure at 45-100 ° C. and dried to obtain a powdered extract.

Example 2. Preparation of Green Tea Extract

2-1. Green tea water extract manufacturer

Dried green tea (purchased in Gyeongdong market) was placed in an extractor with a cooler with 5-30 times the weight of green tea, extracted for 2 to 3 hours at 90-100 ° C., and filtered to obtain a primary extract. After filtration, water was added as a primary extraction solvent to the residue, and extracted for 1 to 2 hours to obtain a secondary extract. The primary and secondary extracts were mixed to obtain green tea extract. The extract was concentrated under reduced pressure at 45-100 ° C. and dried to obtain a powdered extract.

2-2. Manufacture of Green Tea Water Alcohol Extract

Dried green tea (purchased in Kyungdong Market) was placed in an extractor with a cooler with 70% ethanol, 5-30 times the weight of green tea, extracted at 90-100 ° C. for 2-3 hours, and filtered to obtain a primary extract. After filtration, 70% ethanol as a primary extraction solvent was further added to the residue, followed by extraction for 1 to 2 hours to obtain a secondary extract, and a mixture of primary and secondary extracts was used as green tea extract. The extract was concentrated under reduced pressure at 45-100 ° C. and dried to obtain a powdered extract.

Example 3 Preparation of Hangover Relief Composition

The herbal extracts obtained in Examples 1 and 2 were combined at a predetermined ratio to prepare a hangover composition of the present invention.

3-1. Hangover Relief Composition Preparation Example 1

Constituent medicinal herbs for Hangover Relief 40% by weight, 40% by weight green tea extract, 1% by weight honey, 1% by weight alanine, 1% by weight aspartic acid, 1% by weight nitrate, 1% by weight taurine, 1 ascorbic acid 1 A composition for hangover relief was prepared by blending it in weight percent, magnesium carbonate 1%, potassium citrate 1%, and water.

3-2. Hangover Relief Composition Preparation Example 2

The composition of the composition for relieving hangover 40% by weight Ogapi extract, 20% by weight green tea extract, 1% by weight honey, 1% by weight alanine, 1% by weight aspartic acid, 1% by weight nitrate, 1% by weight taurine, 1 ascorbic acid 1 A composition for hangover relief was prepared by blending it in weight percent, magnesium carbonate 1%, potassium citrate 1%, and water.

3-3. Hangover Relief Composition 3

Constituent medicinal herbs for Hangover Relief 20% by weight, green tea extract 40%, honey 1%, alanine 1%, aspartic acid 1%, nitrate 1% by weight, taurine 1%, ascorbic acid 1 A composition for hangover relief was prepared by blending it in weight percent, magnesium carbonate 1%, potassium citrate 1%, and water.

3-4. Hangover Relief Composition 4

The composition of the composition for relieving hangover, 20% by weight of Ogapi extract, 30% by weight green tea extract, 1% by weight honey, 1% by weight alanine, 1% by weight aspartic acid, 1% by weight nitrate, 1% by weight taurine, 1 ascorbic acid 1 A composition for hangover relief was prepared by blending it in weight percent, magnesium carbonate 1%, potassium citrate 1%, and water.

Reference example. Blood Alcohol Analysis Using GC-MS

In this experiment, n-propanol was used as an internal standard solution used in GC-MS for measuring blood alcohol concentration, and tested according to gas chromatograph-mass spectrometry under the conditions shown in Tables 1 and 2 below.

GC condition column   HP INNOWax 30.0 m × 250 μm × 0.15 μm Column temperature   40 ° C (0-3 minutes), 5 ° C / minute (up to 100 ° C), 20 ° C / minute (up to 240 ° C) Inlet temperature   230 ℃ Carrier Gas   Helium split mode-flow rate: 0.8 ml / min Split ratio-25: 1 split flow
30.0 ml / min   Total flow-33.9 ml / min

MS condition SIM mode (0 to 3 minutes: 44 m / z, 3 to 5.5 minutes: 45 m / z, after 5.5 minutes: 59 m / z)

Experimental Example 1 Animal Test of Blood Alcohol Concentration in Ogapi and Green Tea Extracts

Omgapi extract prepared in Example 1-1, green tea extract prepared in Example 2-1 and the composition of Example 3-1 orally administered 100mg / kg to a mouse of 180 ~ 220g body weight, after 1 hour 3 g / kg alcohol was administered orally. After alcohol administration, blood was collected at 0.5, 1, 2, 4, 6, 8 hour intervals to measure blood alcohol concentration using GC / MS, and the parameters of C _max , T _max , t _1/2 , AUC, etc. Was measured. The animals used in the experiment were fasted for 16 hours before drug administration, and ethanol concentration with time after alcohol administration was shown in FIG. 1. The measured parameter results are shown in Table 3 below.

According to the results of Figure 1, the group administered with the composition of Example 3-1 of the present invention was found to have the lowest blood alcohol concentration than the control group, green tea extract administration group and Ogapi extract administration group.

Various pK Parameters of Blood Alcohol Levels Digested and Absorbed by SD Mice Control group Green tea extract Ogapi Extract Mixed composition C _max (g / ml) 4268.2 3513.5 2259.2 2015.1 T _max (hr) 2.0 2.0 2.0 2.0 t _1/2 (hr) 3.63 4.27 5.40 4.85 Total AUC
(g.hr/ml) 21634.3 18615.8 13365.1 10713.4 AUC% 100 86.0 61.7 49.5

In the results of Table 3, the blood maximum concentration (C _max ) of the absorbed alcohol was about 82% in the green tea group and about 53% in the ogapi group compared to the control group, but the amount of the green tea and the ogapi extract was reduced by 1/2, respectively. The total blood concentration curve area (total AUC) was about 86.0% in the green tea group, about 61.7% in the Ogapi group, and about 49.5% in the mixture group compared to the control group. As a result of the important parameters C _max and AUC, it was confirmed that the alcohol dissociation effect was excellent in the mixture administration group than when the green tea and Ogapi extract were administered alone.

Experimental Example 2 Blood Alcohol Concentration Comparison of Hangover Composition and Commercially Available Products of the Present Invention

10-15 ml / kg of the composition prepared in Example 3-1 and a third-party product were orally administered to mice between 180 and 220 g of body weight, and 3 g / kg of alcohol was orally administered after 1 hour. After alcohol administration, blood was collected at 0.5, 1, 2, 4, 6, 8 hour intervals to measure blood alcohol concentration using GC / MS, and the parameters of C _max , T _max , t _1/2 , AUC, etc. Was measured. The animals used in the experiment were fasted for 16 hours before drug administration, and ethanol concentration over time after alcohol administration was shown in FIG. 2. The measured parameter results are shown in Table 4 below.

2, the group administered with the composition of Example 3-1 of the present invention was found to have the lowest blood alcohol concentration than the other company's product administration group.

Various pK Parameters of Blood Alcohol Levels Digested and Absorbed by SD Mice Control group Mixed composition Company A Company B Company C C _max (g / ml) 4268.2 2375.6 2701.7 2576.9 2751.2 T _max (hr) 2.0 2.0 2.0 2.0 2.0 t _1/2 (hr) 3.63 2.49 1.71 2.83 2.81 Total AUC
(g.hr/ml) 21634.3 11541.4 15269.1 13561.0 14877.59 AUC% 100 53.3 70.6 62.7 68.8

In addition, in the results of Table 4, the highest blood concentration (C _max ) of the absorbed alcohol was about 63% in the A company, about 60% in the B company, about 64% in the C company, and the mixed composition thereof. The total blood concentration area (total AUC) was about 70.6% in the A company, about 62.7% in the B company, about 68.8% in the C company, and the mixed composition group. About 53.3%. As a result of the important parameters C _max and AUC, it was confirmed that the company's administration group has superior alcohol degrading effect than the A, B and C company administration group.

Although formulation examples of the composition of the present invention will be described, the present invention is not intended to be limited thereto but merely to describe in detail.

Preparation Example 1. Preparation of powder

Example 3-1 20 mg of composition

Lactose 100 mg

Talc 10 mg

The above components are mixed and filled in airtight bags to prepare powders.

Formulation Example 2. Preparation of tablets

Example 3-1 10 mg of composition

Corn starch 100 mg

Lactose 100 mg

2 mg magnesium stearate

After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.

Formulation Example 3 Preparation of Capsule

Example 3-1 10 mg of composition

Crystalline cellulose 3 mg

Lactose 14.8 mg

Magnesium stearate 0.2 mg

According to a conventional capsule preparation method, the above ingredients are mixed and filled into gelatin capsules to prepare capsules.

Formulation Example 4. Preparation of injection

Example 3-1 10 mg of composition

180 mg mannitol

Sterile sterilized water for injection 2974 mg

Na ₂ HPO _4? 12H ₂ O 26 mg

(2 ml) per 1 ampoule according to the usual injection preparation method.

Formulation Example 5 Preparation of Liquid

Example 3-1 20 mg of composition

10 g per isomer

5 g mannitol

Purified water

Each component was added to purified water in accordance with the usual liquid preparation method and dissolved, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was adjusted to 100 ml with purified water, And sterilized to prepare a liquid preparation.

Formulation Example 6 Preparation of Health Functional Food

Example 3-1 1000 mg of composition

20 g of vitamin mixture

70 μg of Vitamin A Acetate

Vitamin E 1 mg

0.13 mg of vitamin B ₁

0.15 mg of vitamin B ₂

0.5 mg of vitamin B ₆

Vitamin B ₁₂ 0.2 g

Vitamin C 10 mg

Biotin 10 μg

Nicotinic acid amide 1.7 mg

Folate 50 ㎍

Calcium pantothenate 0.5 mg

Mineral mixture quantity

1.75 mg of ferrous sulfate

Zinc Oxide 0.82mg

Magnesium carbonate 25.3 mg                     

15 mg of potassium phosphate monobasic

Secondary calcium phosphate 55 mg

Potassium citrate 90 mg

100 mg of calcium carbonate

Magnesium chloride 24.8 mg

Although the composition ratio of the vitamin and mineral mixture is a composition suitable for a relatively healthy food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health functional food production method. The granules may be prepared and used for preparing the nutraceutical composition according to a conventional method.

Formulation Example 7 Preparation of Health Functional Drink

Example 3-1 1000 mg of composition

Citric acid 100 mg

100 g of oligosaccharide

Plum concentrate 2 g

1 g of taurine

Add 900 ml of purified water

After mixing the above components according to the conventional healthy beverage manufacturing method, and stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 ℃ container, sealed sterilization and refrigerated It is used to prepare the health functional beverage composition of the invention.

Although the compositional ratio is relatively mixed with a component suitable for a favorite drink, it is also possible to arbitrarily modify the compounding ratio according to the regional or national preference such as the demand class, the demanding country, and the use purpose.

As described above, the hangover cure composition of the present invention is an active ingredient such as natural herbal medicines such as Ogapi and green tea has no side effects on the human body and has an excellent hangover relieving effect and excellent soy sauce protection drug containing it as an active ingredient And dietary supplements can be useful for the hangover and liver protection before and after drinking.

Claims (8)

Hangover and soy sauce protection pharmaceutical composition containing 2 to 40% by weight Ogapi extract and 2 to 40% by weight green tea extract (wherein the composition contains more than 1% extract solids). delete delete delete The pharmaceutical composition according to claim 1, which is a tablet, capsule, soft capsule, pill, granule or liquid. Hangover and soy sauce protective functional foods containing 2 to 40% by weight of ogapi extract and 2 to 40% by weight green tea extract and food acceptable food supplements, provided that the health functional food contains more than 1% extract solids box). delete 7. The dietary supplement of claim 6, wherein the dietary supplement is in the form of a powder, granule, tablet, capsule or beverage.

Images