KR100696589B1 - Composition comprising the extract of Theragra chalcogramma, Hovenia dulcis and Viscum album var. coloratum and catechins of Pueraria thunbergiana for treating or alleviating hangover syndrom and protecting liver - Google Patents

Abstract

The present invention relates to a hangover and liver protection composition containing 80-90% by weight of the yellow extract, 0.1-5% by weight of the bark tree extract, 0.1-10% by weight of the mistletoe extract and 0.1-5% by weight of the catechin component In detail, the composition of the present invention promotes metabolism of alcohol and aldehyde, which causes hangover, to increase alcohol degradation in the body, and has an excellent liver protection effect, which is useful for hangover and liver protection. In addition, it has an activity of inducing mucosal immunity and increasing basal metabolic rate, and also decreases blood glucose levels, and decreases blood cholesterol and triglyceride levels, which have antidiabetic activity. It is not a food, but hangover can also prevent adult diseases such as diabetes. A yonghan invention.

Hangover, Liver Protection, Emperor

Description

Composition comprising the extract of Theragra chalcogramma, Hovenia dulcis and Viscum album var. coloratum and catechins of Pueraria thunbergiana for treating or alleviating hangover syndrom and protecting liver}

1 and 2 is a view showing the effect on the enzyme activity of ADH (Fig. 1) and ALDH (Fig. 2) of the hangover composition of the present invention,

3 and 4 are views showing the effect on the blood alcohol concentration (Fig. 3) and aldehyde concentration (Fig. 4) of the hangover composition of the present invention,

5 is a view showing the effect of the composition of the present invention on GOT, GPT and LDH,

6 to 8 are views showing the effect on the mucosal immune activity in the serum (Fig. 6), feces (Fig. 7), vaginal lavage (Fig. 8) of the composition of the present invention,

9 is a view showing the effect on the blood glucose concentration of the composition of the present invention,

10 and 11 are diagrams showing the effect on the blood cholesterol (Fig. 10) and triglyceride in the blood (Fig. 11) of the composition of the present invention,

12 is a diagram showing the effect of the composition of the present invention on the change of basal metabolic rate.

The present invention relates to a hangover and liver protection composition containing 80-90% by weight of the extract of the yellow, 0.1-5% by weight of the bark tree extract, 0.1-10% by weight of the mistletoe extract and 0.1-5% by weight of the catechin component.

Alcohol has not only been manufactured and consumed in human society for a long time, but it is also manufactured and sold in almost every country except the Islamic religion.

According to a survey conducted by 1,600 people at Samsung Hospital on the drinking culture of the workplace and health awareness of the liver, Koreans in their 20s and 50s drink about 87.1% of the alcoholic beverages 1 to 3 times a week. In terms of health, it is quite worrying.

As such, modern people consume excessive amounts of alcohol so much that they cannot digest it, causing side effects such as thirst, general boredom, fatigue, memory loss, bloating, indigestion, vomiting, diarrhea and vitamin deficiency. Many people suffer from the phenomenon, and the risk of alcoholism increases.

Normal alcohol metabolism is ingested by alcohols (ethyl alcohol, methyl alcohol, ethylene glycol, etc.), absorbed from the stomach or small intestine, 10% of which is excreted by breathing, sweating, urine, etc. Enters into blood vessels and is metabolized in the liver (M. Nakanishi; Saishin Igaku , 31 , p2086, 1976). Subsequently, alcohol dehydrogenase (ADH) present in hepatocytes oxidizes alcohol to acetaldehyde, and acetaldehyde is decomposed into acetic acid by acetaldehyde dehydrogenase in hepatocytes and transferred to muscle or adipose tissue throughout the body. Finally, it is decomposed into carbon dioxide gas and water. However, in this decomposition metabolic process, when alcohol metabolism abnormalities come due to excessive drinking, most suffer from hangovers such as heavy, painful, or sore throat due to un metabolized ethyl alcohol or acetaldehyde.

As part of the research on this phenomenon, compositions using choline acids, which are widely used as gallstone solubilizers, have been developed and marketed. These choline acids have an effect of edema, hepatic detoxification, hepatic blood flow improvement, fat absorption and fine action. Ursodeoxycholic acid, which is known to be effective in improving the liver function of chronic liver disease, systemic malaise due to hepatic dysfunction, indigestion, anorexia, physical fatigue due to biliary excretion, It is marketed as a gallstone dissolving agent, and is effective in treating fatty liver, and when administered orally, improvement of liver function and reduction of liver fat mass have been reported (Japanese Patent Laid-Open Publication No. 4-235918) Taurorusodeoxycholic acid ), And commercially available cheodeoxycholic acid and dehydrocholic acid as gallstone dissolving agents. .

However, the composition using choline acids is effective in general symptoms caused by stress such as increase of adrenal weight by stress and prevention of spleen atrophy, suppression of ascorbic acid content change of adrenal gland and suppression of blood biochemical changes. It has only been proven and there is no mention of a hangover-protective effect on the liver.

Therefore, there is an urgent need for the development of new oral hangovers and liver protection that are effective without any side effects.

Diabetes is defined as a metabolic disorder caused by insulin secretion and a lack of action of insulin secreted by pancreatic cells and involves excessive production of glucose, breakdown of body fat and waste of protein, and abnormal glands of glucagon, resulting in metabolic disruption. (Abrams, JJ, Ginsberg, H, et al., Diabetes, 31 , pp 903-910, 1982).

Diabetes mellitus is characterized by two types, type 1 diabetes mellitus, which is caused by a lack of secretion of insulin, a glucose-regulating hormone in the blood, mainly in young people in their 10s to 20s. It is also called juvenile diabetes because it occurs in. Type 2 diabetes mellitus occurs mainly after the age of 40, and occupies most of the diabetic patients in Korea. Unlike type 1, it is called adult-type diabetes and the cause of the disease is not clear yet, but it is known that the genetic factor and the environmental factors are involved together. As a etiology of type 2 diabetes, both insulin secretion in pancreatic beta cells and defects in insulin action (insulin resistance) in target cells are observed.

The most important goal in the treatment of diabetes is to control blood glucose levels as close to normal as possible, and postprandial glycemic control, together with fasting blood glucose, is important for improving diabetes and preventing and treating complications (Jenkins, DJA, Wolever et al., Starchy foods and glycemic index, Diabetes Care , 11 , pp149-159, 1988; Menendez, CM, Stoecker, BJ, The role of diet in improving glycemic control in Nutrition and Diabetes, Javanovic, L. and Peterson, CM (ed.) Alan R. Liss Inc., pp 15-36, 1995).

Pollack ( Theragra chalcogramma ) is divided into dynamic, yellow, and north, depending on how it is constructed. Hwangtae used in the present invention repeatedly makes the process of freezing and melting from December to the following year in April and April in the region where the day crossing is large and cold. During the day, the surface melts slightly, and at night repeats the freezing more than 20 times to become a good emperor. The meat is soft and fishy, and the soft and deep flavor is preserved for a long time. The main ingredient in pollock is protein and is also rich in calcium. Undried common size pollack contains 20.3g of protein, 100mg of calcium, 4.2mg of iron, 202mg of phosphorus, 0.9mg of sugar, 4.2mg of iron, rich in vitamins, and protein content doubles when dried pollack do. Pollack liver oil (oil extracted from the liver) contains vitamin A, which is excellent in nutritional value, contains essential amino acid called lysine and tryptophan, which is a nutrient for the brain, necessary for the development of cells in each part of the human body. Are relatively small, so obese patients and the elderly can eat with confidence. Pollack is good for feverish diseases, and it is effective for acute diseases caused by cold soreness and other infections.

Of the various forms of pollack, the most advanced is the Emperor. It is also called Deokbukbuk because its flesh and aroma are comparable to that of Deukdeok in the mountains. As pollack dries and becomes double, the amount of protein doubles, making it a high-quality protein food that accounts for 56% of all ingredients. Because it is a high protein and low calorie, it is also good as a diet food, it is effective for fatigue and blood pressure control. The most surprising effect of pollack is that it changes the allergy constitution.

Hovenia dulcis is a tree of the sea buckthorn family, also known as earth tree and zombies. Sucrose, glucose, fructose, catalase, and peroxidase are found in the fruit pacifier. The total sugar is about 13%, almost the same amount of glucose and sucrose is contained, and the sugar is contained under the shell and on the conduit. The neck contains triterpenoids, hobenic acid, and the leaves contain rutin. It stops nausea and can't urinate.

Thunbergiana Bentham is a perennial herb that grows on vines. At the root of the vine is Disode, an isoflavone compound, Dydzein, Fueranin, Fueranxylside, Luteolin, Biocanin A, etc. Coumarin and the like. The isoflavone compound in the roots has a hardening effect, and Dyzedine is effective for migraines, hypertension, angina pectoris, etc.

Mistletoe ( Viscum album var. Coloratum ) is a small evergreen tree, and its leafy branches include alkaloids, flavonoids and saponins, oleanolic acid, β-amirin, mesoinositol, biscuin, oxidase, and seryl alcohol. Mistletoe is excellent for uterine contraction and hemostatic action.

Accordingly, the present inventors have completed the present invention by confirming that the composition containing the catechin component of the yellow, bark, mistletoe and 칡 is useful for relieving hangover, and protects the liver and lowers blood glucose.

An object of the present invention is an anti-hanging and liver protection composition or anti-histery containing 80-90% by weight of the yellow extract, 0.1-5% by weight of the bark tree extract, 0.1-10% by weight of the mistletoe extract and 0.1-5% by weight of the catechin component It is to provide a diabetic composition.

In order to achieve the above object, the composition for the hangover and liver protection containing 80-90% by weight of the yellow extract, 0.1-5% by weight of the bark tree extract, 0.1-10% by weight of the mistletoe extract and 0.1-5% by weight of the catechin component To provide.

In addition, diabetes containing 80-90% by weight of the yellow extract, 0.1-5% by weight of the bark extract, 0.1-10% by weight of mistletoe extract and 0.1-5% by weight of the catechin component Provided is a prophylactic antidiabetic composition.

In addition, the present invention is 80-90% by weight of the yellow extract, 0.1-5% by weight of larvae extract, 0.1-10% by weight of mistletoe extract and 0.1-5% by weight of catechin component of hangover extract and liver protection prevention and improvement effect It provides a health functional food comprising a composition containing and a food supplement acceptable food additive.

The dietary supplement includes a form that is a powder, granules, tablets, capsules or beverages, and preferably includes a form of a beverage.

Hereinafter, the present invention will be described in detail.

The catechin component of the yellow, barberry and mistletoe extract of the present invention and 칡 can be prepared by the following method.

In the case of the yellow extract, 5-10 volumes of purified water is added to the extract, which is domestically available, and placed in the extractor for 24-36 hours at 80-100 ° C, preferably 85-95 ° C, preferably 24- Extract hot water for 26 hours.

To remove any foreign matter on the surface of barn, mistletoe and stalks, it is washed, cut into 5-10cm lengths, dried in the shade or dried and then crushed or used about 5-30 times, preferably 10-15 times volume / weight of water, lower alcohols (ethanol, etc.) or a mixed solvent thereof, and filtered by hot water extraction for 10 minutes to 15 hours at an extraction temperature of 70-120 ° C., preferably 90-100 ° C. The supernatant can be separated by centrifugation, preferably filtered to obtain the respective herbal extracts, and additionally concentrated or dried to obtain dry hut or mistletoe extracts and the catechin component of mussels.

The catechin component of 칡 includes epigallocatechin gallate (EGCG), epigallocatechin (epigallocatechin), epicatechin gallate (epicatechingallate), epicatechin (epicatechin), gallocatechin (gallocatechin) or catechin (catechin) , Preferably epigallocatechin gallate, epicalocatechin, epicatechin.

The present invention is 80% to 90% by weight of the yellow extract obtained by the above-mentioned method, 0.1-5% by weight of bark tree extract, 0.1-10% by weight of mistletoe extract and 0.1-5% by weight of catechin component of 칡 and liver It provides a protective composition.

The above composition may be prepared by mixing the extracts obtained, respectively, and may also be prepared by adding the locust extract, mistletoe extract and catechin component of the larvae at the time of preparation of the emperor extract.

After oral administration of the composition to mice, oral administration of alcohol resulted in measurement of blood alcohol concentration and acetaldehyde concentration in the mouse. As a result, an excellent alcohol degrading effect was confirmed in mice to which the composition of the present invention was administered, and blood GOT, GPT As a result of measuring the concentration of LDH, excellent hepatoprotective effect was confirmed. In addition, it was confirmed that the composition of the present invention increases the mucosal immunity of mice, the administration of the composition of the present invention to diabetic rats resulted in an excellent decrease in blood glucose levels and a decrease in blood cholesterol and triglyceride levels. , An excellent increase in basal metabolic rate was found.

The present invention contains 80-90% by weight of the yellow extract, 0.1-5% by weight of larvae extract, 0.1-10% by weight of mistletoe extract and 0.1-5% by weight of catechin component It provides an antidiabetic composition for preventing diabetes.

In addition, the yellow, barn, mistletoe and 나무 of the present invention has been used as an edible and herbal medicine for a long time, the extracts of the present invention extracted therefrom also have no problems such as toxicity and side effects.

In addition, the present invention is 80-90% by weight of the yellow extract, 0.1-5% by weight of larvae extract, 0.1-10% by weight of mistletoe extract and 0.1-5% by weight of catechin component of hangover extract and liver protection prevention and improvement effect It provides a health functional food comprising a composition containing and a food supplement acceptable food additive.

Examples of the food to which the composition of the present invention can be added include various foods, beverages, gums, teas, vitamin complexes, and health functional foods. It may also be added to foods or beverages for the purpose of preventing hangovers and protecting the liver. At this time, the amount of the composition in the food or beverage may be added to 0.01 to 15% by weight of the total food weight, the health beverage composition may be added in a ratio of 0.02 to 5g, preferably 0.3 to 1g based on 100ml. The health functional beverage composition of the present invention is not particularly limited to other ingredients except for containing the composition as an essential ingredient in the indicated ratios, and may contain various flavors or natural carbohydrates, etc. as additional ingredients, such as ordinary drinks. Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And conventional sugars such as polysaccharides such as dextrin, cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The ratio of the natural carbohydrate is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention, in addition to the composition of the present invention, various nutrients, vitamins, minerals (electrolytes), synthetic flavors And flavoring agents such as natural flavoring agents, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, Carbonating agents used in carbonated drinks, etc. In addition, the compositions of the present invention may contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. The powders may be used independently or in combination The ratio of such additives is not so critical but is usually selected in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following Examples and Experimental Examples. The following Examples and Experimental Examples are examples of the present invention, and the present invention is not limited thereto.

Example 1 Preparation of Yellow Extract

After washing one of the yellow cattle purchased from Yongpyong, Gangwon-do, purified water, and then added purified water of 10 times the weight of the yellow impregnated water into the extractor and hot water extraction and filtration for 24 hours at 90 ℃ to obtain a yellow extract.

Example 2. Preparation of Bare Tree Extract

After purchasing 1 kg of Korean domestic bark tree native to Korea and washing it with water, purified water was added to the extractor with 10 times the weight of the bark tree, and the hot water was extracted at 90 ° C for 15 hours, and then cooled at 70 ° C. Each of the extracts obtained by repeating the above procedure three times was mixed, filtered through a microfilter, transferred to a concentrator, and concentrated in vacuo to brix 74 to obtain a bark extract.

Example 3. Preparation of the catechin component of bovine

1 kg of domestic Korean wild ginseng native to Korea was performed in the same manner as in Example 2 to obtain catechin components of wild boar.

Example 4. Preparation of Mistletoe Extract

1 kg of leaves and stems from the end of the branches of 2 year-old Korean mistletoe to 2 nodes were collected and washed well with distilled water, and 10 liters of purified water was added and homogenized for 3 minutes. The homogenous mistletoe was bathed at 100 ° C. for 30 minutes and centrifuged at 4 ° C., 10,000 × g for 2 minutes to obtain a supernatant, and the supernatant obtained was filtered sequentially with a membrane filter having a different pore size to obtain impurities. After removal, lyophilization gave a brown powder.

Example 5 Preparation of Hangover Relief Composition

5-1. Preparation of hangover relief 1

80% by weight of the yellow extract obtained in Example 1 0, 0.1, 0.5, 1, 2, 3, 4, 5% by weight of each of the extracts added to the purified water and then homogenized to fill the beverage container, packaging After sterilization to prepare a hangover composition.

5-2. Preparation of hangover relief 2

Using the same method as prepared in Example 5-1 Mistletoe extract 0, 0.1, 0.5, 1, 2, 3, 4, 5, 10% by weight, respectively, to prepare a hangover composition.

5-3. Preparation for hangover relief 3

Using the same method as described in Example 5-1, 0, 0.1, 0.5, 1, 2, 3, 4, and 5% by weight of catechin components were respectively mixed to prepare a hangover composition.

5-4. Preparation of hangover relief 4

Based on the sensory evaluation results of Experimental Example 1 80% by weight of the yellow extract, 2% by weight of the bark tree extract, 0.5% by weight of mistletoe extract and 0.5% by weight of the catechin component of 칡 and the method performed in Example 5-1 In the same manner, a hangover composition was prepared.

Experimental Example 1. Sensory Evaluation

For each hangover relief composition prepared in Example 5 based on the 5 rating method (best: 5-4, excellent: 3, normal: 1-2, the lowest: 0) for 50 workers over 30 years old The sensory evaluation was repeated three times and the average was examined.

As a result of the experiment, as shown in Table 1 below, as a result of sensory evaluation of the hangover removal composition according to the content of the bark tree extract prepared in Example 5-1, 0.1-2% by weight of the bark tree extract When it was confirmed that the most excellent in terms of taste, aroma and color of the hangover relief composition, the content of the mistletoe extract prepared in Example 5-2 when the content of the mistletoe extract (0.1-0.5% by weight) 2), in the case of the hangover composition prepared in Example 5-3 when the content of the catechin component of 칡 0.1-0.5% by weight (see Table 3 below) taste, flavor and color of the hangover composition The most excellent was found in.

Sensory Evaluation Results of Hangover Relief Compositions by Contents Rhododendron extract content (% by weight) flavor incense Color 0 4.5 4.0 4.0 0.1 4.5 4.0 4.2 0.5 4.5 3.8 4.2 One 4.0 3.5 4.2 2 4.0 3.5 4.0 3 3.5 3.0 3.0 4 3.0 2.0 1.5 5 1.5 1.5 One

Sensory Evaluation Results of Mistletoe Extracts by Composition Mistletoe extract content (% by weight) flavor incense Color 0 4.5 4.0 4.0 0.1 4.5 3.8 4.2 0.5 4.0 3.5 4.2 One 3.5 3.2 3.2 2 3.5 3.2 3.0 3 3.0 3.0 3.0 4 2.5 2.0 1.5 5 1.5 1.5 One 10 One One One

Sensory Evaluation Results of Hangover Relief Compositions by Contents Catechin content (wt%) flavor incense Color 0 4.5 4.0 4.0 0.1 4.5 4.2 4.2 0.5 4.0 4.0 4.2 One 3.5 3.2 3.2 2 3.5 3.2 3.0 3 3.0 3.0 3.0 4 2.5 2.0 1.5 5 1.5 1.5 One

Experimental Example 2. Hangover Efficacy Experiment

The control group was administered only alcohol, and the experimental group was orally administered to the male hangover composition prepared in Example 5-4 to 10 male rats weighing about 200 g SD, 30 minutes orally before alcohol administration 30 minutes before After 1, 3, 5 hours the serum was separated and tested. In this experiment, alcohol was orally administered with 40% ethanol at 10 ml / kg per male rat. Serum ADH and ALDH were measured by in vitro assay, blood alcohol and acetaldehyde concentration were measured by in vivo assay. All experimental kits were purchased from Asan Pharmaceutical.

As a result of the experiment, as shown in FIGS. 1 and 2, the experimental group to which the composition of the present invention was administered was found to have significantly increased ADH and ALDH activity compared to the control group, and also as shown in FIGS. 3 and 4. As described above, in the experimental group to which the composition of the present invention was administered, it was confirmed that the concentration of alcohol and aldehyde in the blood was significantly reduced as compared to the control group. It can be seen that to promote the decomposition of.

Experimental Example 3. Liver protection efficacy experiment

As an experimental group, 10 male rats weighing about 200 g in SD system were fasted for 16 hours, and then prepared in Example 5-4 in 1% CMC-Na solution 4 hours before and 16 hours after administration of CCl ₄ mixture. The composition of the present invention was suspended orally at a dose of 1 g / kg / 15 ml, and CCl ₄ : oil mixture (1: 4, v / v%) was administered intraperitoneally at 200 µl per 100 g of body weight. Silymarin 25 mg / kg / 10ml was orally administered as a positive control. 48 hours after administration, the abdominal aorta was taken open under ether gut and GOT, GPT, and LDH activities were measured using Sikhma kit.

As a result of the experiment, the experimental group and the positive control group administered the composition of the present invention as shown in Figure 5 showed a significant value as compared to the normal group that was not administered any sample as a normal rat.

Experimental Example 4. Mucosal immune activity experiment

10 male rats weighing about 200 g in SD system were orally administered with the composition prepared in Example 5-4 once per two weeks at two week intervals, and fecal (fecal) four weeks after the experiment. Extract, vaginal wash and serum were separated to observe antigen specific antibody titers. The control group was the group not administered any sample.

As a result of the experiment, it was confirmed that the experimental group administered with the composition of the present invention in the case of serum showed a remarkably superior mucosal immunity activity of about 700 times as compared to the control (see FIG. 6), and in the case of feces, about 150 times ( In the case of vaginal lavage solution, it was confirmed that about 150 times (Fig. 8) the experimental group showed significantly superior mucosal immune activity compared to the control group. Therefore, when the composition of the present invention is administered, the immune cells are activated to keep the body healthy, thereby increasing the alcohol detoxification rate and indirectly affecting the hangover.

Experimental Example 5. Antidiabetic Activity

The blood glucose level was measured after oral administration of 5 mg of the composition prepared in Example 5-4 to the ob / ob mouse, a diabetic disease model animal, once daily. The control did not receive any samples.

As a result of performing the experiment, as shown in FIG. 9, in the control group, the blood glucose level continuously increased as the seal passed, whereas in the experimental group to which the composition of the present invention was administered, the blood glucose level was about 60% as the seal passed. It was confirmed that the above significantly reduced.

Experimental Example 6. Effect on Blood Lipid Levels

Diabetic disease model animals ob / ob mice obtained free blood for 15 days after the composition of the present invention prepared in Example 5-4 for 15 days to collect blood on 15 days to measure the levels of cholesterol and triglycerides related to diabetes-related blood components It was.

As a result of performing the experiment, the blood cholesterol level was reduced by about 70% compared to the control in the experimental group to which the composition of the present invention was administered (see FIG. 10), and the level of triglyceride was reduced by about 50% compared to the control. I could confirm it.

Experimental Example 7. Observation of changes in basal metabolic rate

The effect of the composition of the present invention on the basal metabolic rate was observed. Male mice weighing about 20 g of Balb / c were administered orally with 2 mg of the composition prepared in Example 5-4 once daily. After 2 weeks, 3 weeks, and 4 weeks, basal metabolism was measured. The control did not receive any samples.

As a result of the experiment, as shown in Figure 12, the experimental group administered with the composition of the present invention was confirmed that the increase in basal metabolic rate of about 1.5 times or more compared to the control, bar strength of the mouse when administering the composition of the present invention This is likely to have a beneficial effect on the hangover.

Although formulation examples of the composition of the present invention will be described, the present invention is not intended to be limited thereto but merely to describe in detail.

Formulation Example 1 Preparation of Health Functional Food

Example 5-4 1000 mg of Composition

20 g of vitamin mixture

70 μg of Vitamin A Acetate

Vitamin E 1 mg

Vitamin B1 0.13 mg

Vitamin B2 0.15 mg

Vitamin B6 0.5 mg

0.2 μg of vitamin B12

Vitamin C 10 mg

10 μg biotin

Nicotinic Acid 1.7 mg

Folate 50 ㎍

Calcium Pantothenate 0.5mg

Mineral mixture

Ferrous Sulfate 1.75 mg

Zinc Oxide 0.82mg

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Dibasic calcium phosphate 55 mg

Potassium Citrate 90 mg

Calcium Carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the vitamin and mineral mixture is a composition suitable for a relatively healthy food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health functional food production method. The granules may be prepared and used for preparing the nutraceutical composition according to a conventional method.

Formulation Example 2 Preparation of Health Functional Drink

Example 5-4 1000 mg of Composition

Citric acid 100 mg

100 g oligosaccharides

Plum concentrate 2 g

1 g of taurine

Add 900 ml of purified water

After mixing the above components in accordance with a conventional healthy beverage production method, and stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 L container, sealed sterilization and then refrigerated and stored in the present invention It is used to prepare a health functional beverage composition.

Although the composition ratio is mixed with a component suitable for a favorite beverage in a preferred embodiment, the composition ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, and usage.

As described above, the present invention for the hangover and liver protection containing 80-90% by weight of the yellow extract, 0.1-5% by weight of the bark tree extract, 0.1-10% by weight of the mistletoe extract and 0.1-5% by weight of the catechin component In detail, the composition of the present invention promotes the metabolism of alcohol and aldehyde, which causes hangover, to increase alcohol breakdown in the body, and has excellent liver protective effect, which is useful for hangover and liver protection. In addition, the composition of the present invention induces mucosal immunity and increases the basal metabolism to keep the body healthy, which has a positive effect on the hangover, and also reduces blood glucose levels, and decreases blood cholesterol and triglyceride levels. It has anti-diabetic activity and can be used as a composition for preventing diabetes. It can help prevent illnesses such as diabetes, it is a very useful invention, the dietary supplement industry.

Claims (4)

Hangover and liver protection composition containing 80-90% by weight of the yellow extract, 0.1-5% by weight of the bark tree extract, 0.1-10% by weight of the mistletoe extract and 0.1-5% by weight of the catechin component. An anti-diabetic composition for preventing diabetes comprising 80-90% by weight of an extract, 0.1-5% by weight of a locust tree extract, 0.1-10% by weight of a mistletoe extract, and 0.1-5% by weight of a catechin component. A composition comprising 80-90% by weight of the yellow extract, 0.1-5% by weight of the larvae extract, 0.1-10% by weight of the mistletoe extract, and 0.1-5% by weight of the catechin component of the larvae and a food acceptable food supplement additive Health functional food. The health functional food according to claim 3, wherein the health functional food is in the form of powder, granule, tablet, capsule or beverage.

Images