KR20130065086A - Composition comprsing alcohol extracts from albatrellus dispansus for treating or preventing hyperlipidemia - Google Patents

Abstract

PURPOSE: A composition containing an alcohol extract of Albatrellus dispansus is provided to suppress cholesterol and neutral fat absorption, and to prevent or treat hyperlipidemia. CONSTITUTION: A composition for preventing or treating hyperlipidemia contains a C1-C10 alcohol extract of Albatrellus dispansus as an active ingredient. A pharmaceutical product for preventing or treating hyperlipidemia contains the extract as an active ingredient. A health functional food for preventing or treating hyperlipidemia contains the extract as an active ingredient. A method for preventing or treating hyperlipidemia comprises a step of administering the extract to animals exclusive of human. The extract suppresses blood cholesterol and/or neutral fat absorption. [Reference numerals] (AA) CEL activity inhibition(%); (BB) Water extract (Comparative example); (CC) Ethanol extract

Description

Composition for the treatment or prevention of hyperlipidemia comprising ethanol extract of flowering mushrooms {COMPOSITION COMPRSING ALCOHOL EXTRACTS FROM ALBATRELLUS DISPANSUS FOR TREATING OR PREVENTING HYPERLIPIDEMIA}

The present invention relates to an extract of a flower shield mushroom, and more particularly, to an alcohol extract of a flower shield mushroom and its use, and a method of obtaining the same, which is effective for treating, preventing, and treating hyperlipidemia.

Hyperlipidemia refers to a condition in which fat is high in the blood. In general, it is called hyperlipidemia when the total cholesterol exceeds 240 mg / dl or triglycerides more than 200 mg / dl. Hyperlipidemia is known to be a major cause of cholesterol, blockage of blood vessels and blood circulation, causing hypertension, myocardial infarction and stroke. In Korea, patients with hyperlipidemia are increasing steadily, and patients with hyperlipidemia are increasing rapidly in the world. Many reports on the treatment, prevention and prescription of hyperlipidemia have been presented.

The cause of hyperlipidemia is metabolic disorders due to genetic factors, but hyperlipidemia also occurs in other causes, such as obesity due to excessive calorie meals and lack of exercise, resulting in accumulation of cholesterol in the blood (Bray GA, Popkin BM. Dietary fat intake dose affect obesity.Am. J. Clin.Nutr 68: 1157-1173 (1998)). Increased intake of high-fat diets due to westernized diets is considered to be the main reason for hyperlipidemia. Currently, the development of cholesterol absorption inhibitor agonists for the prevention or treatment of hyperlipidemia is actively being made worldwide, and accordingly, interest in the antihyperlipidemic efficacy evaluation model is increasing. Triglycerides also promote the reduction of HDL and facilitate the infiltration of LDL into the blood vessel walls, increasing the risk of heart disease stroke atherosclerosis.

Currently, drugs for treating hyperlipidemia are widely used in statins. Drugs of this class are Hmg-CoA reductase inhibitors that inhibit cholesterol synthesis and lower blood LDL-cholesterol. In addition, ezetimibe, niacin, and fibrate preparations are mainly used, but there are concerns that side effects such as muscle pain, constipation, digestive disorders, and liver dysfunction may occur rarely when the drug is administered.

On the other hand, about 10,000 species of mushrooms have been reported around the world, and because of their high edible and medicinal values, many studies have been conducted in Europe, the United States, and Japan to secure them as useful resources for microorganisms. In particular, many studies have reported that physiologically active substances produced by mushrooms are safe in terms of toxicity due to less side effects and have various functions such as regulation of immune system function, anticancer effect and metabolism in human body.

The inventors of the present invention have completed the present invention while researching a natural substance having almost no side effects in vivo and inhibiting cholesterol absorption in the body and having an effect of improving hyperlipidemia.

The present invention provides little or no side effects in vivo, and inhibits the absorption of cholesterol and triglycerides in the body to provide a composition for treating or preventing hyperlipidemia, and a pharmaceutical and a health food containing the same.

In order to achieve the above object, the present invention provides a therapeutic or prophylactic composition for hyperlipidemia comprising an alcohol extract of 1 to 10 carbon atoms of the flowering mushroom as an active ingredient.

In another aspect, the present invention provides a drug for the treatment or prevention of hyperlipidemia comprising an alcohol extract of 1 to 10 carbon atoms of the flowering mushroom as an active ingredient.

In addition, the present invention provides a method for treating or preventing hyperlipidemia, comprising administering a pharmaceutically effective amount of an alcoholic extract having 1 to 10 carbon atoms of a flower patch mushroom to an animal.

In another aspect, the present invention provides a functional food for the improvement or prevention of hyperlipidemia comprising an alcohol extract of 1 to 10 carbon atoms of the flower shield mushroom as an active ingredient.

The present invention provides a therapeutic or prophylactic composition for hyperlipidemia comprising an alcoholic extract having 1 to 10 carbon atoms of the flowering mushroom as an active ingredient.

Albatrellus dispansus belongs to the fungi family and is a wood brown fungus that grows on the stumps of hardwoods from spring to autumn, and its surface is white or light yellow. There is no stand, the hole is yellow and the hole is circular or irregular. The flesh is white, fleshy and easily broken when dried.

The inventors of the present invention are natural substances that can substitute for drugs such as statins, and during the study of inhibitors for inhibiting resorption of cholesterol in the small intestine or reducing blood cholesterol, extracts of flowering mushrooms, in particular It was found that the alcohol extracts of the flowering mushrooms effectively inhibit the absorption of cholesterol in the blood. In addition, the alcohol extract of the flower shield mushroom was confirmed to be effective in inhibiting the absorption of triglycerides to complete the present invention. The extract is effective in the treatment and prevention of hyperlipidemia, and will be effective in the treatment, prevention and improvement of obesity.

On the other hand, the alcohol extract of the flower shield mushroom as described above may be prepared according to the method for producing a conventional plant extract. Preferably, after drying and grinding the flower shield mushroom, the residue is removed, and then 0.1 to 20 g of the ground powder is added per 100 ml of alcohol, more preferably 1 to 5 g of the ground powder per 100 ml of the extraction solvent. , Can be extracted. If the content of the flower shield mushroom is too small compared to the extraction solvent, it is not preferable because the effect of the flower shield mushroom is not sufficient, and if it is too large compared to the amount of the extraction solvent, the effect of increasing the content is not large, but the production cost This increase is undesirable in terms of productivity.

At this time, the extraction conditions are not limited, but it is preferable to mix flower mushroom with ethanol as an extraction solvent, and then, at a temperature of 20 to 60 ° C for 12 to 36 hours, more preferably at a temperature of 30 to 40 ° C It can be extracted for 20 to 24 hours.

In the case of extracting at an excessively low temperature condition, a long time is required for the extraction of the active ingredient, and in the case of extracting at an excessively high temperature condition, the activity may be reduced, which is not preferable. In addition, when the extraction time is too short, the concentration of the active ingredient to be extracted is low, and when extraction for an excessively long time, the increase in the concentration of the weight active ingredient with the increase of the extraction time is insignificant, which is not preferable in terms of productivity.

Then, the alcohol extract of the flower shield mushroom extracted by the above method is filtered through a filter cloth, etc., the filtrate is centrifuged to remove the precipitate, and then concentrated under reduced pressure or concentrated, and then freeze-dried.

On the other hand, the content of the alcohol extract of the flowering mushrooms as an active ingredient in the treatment or prevention composition for hyperlipidemia of the above-described embodiment is not limited, but may preferably be 0.001 to 50% by weight. When the content of the water extract of the flower shield mushroom, which is an active ingredient, is less than 0.001% by weight, the effect of inhibiting cholesterol absorption in the body is insignificant; . More preferably, the content of the alcohol extract of the flowering mushroom in the composition may be 0.01 to 30% by weight, most preferably 0.1 to 30% by weight.

The present invention provides a medicament for the treatment or prevention of hyperlipidemia comprising an alcohol extract of the flower shield mushroom contained in the composition as an active ingredient according to the embodiment. Medicines containing the alcohol extract of the flower shield mushroom as an active ingredient may further comprise a suitable carrier, excipients and diluents commonly used in the preparation thereof.

Carriers, excipients and diluents that may be included in the pharmaceutical preparations containing the alcohol extract of the flower shield mushroom of the present invention as an active ingredient include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, Alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. .

Medicines containing the alcohol extract of the flower shield mushroom of the present invention as an active ingredient can be used in oral formulations, such as powders, granules, tablets, suspensions, emulsions, syrups, respectively, according to a conventional method.

The oral formulation is meant to include a solid preparation and a liquid preparation for oral administration, the solid preparation for oral administration may include tablets, pills, powders, granules, capsules, etc., such solid preparation is the extract At least one excipient, for example, may be prepared by mixing starch, calcium carbonate, sucrose or lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral use include suspensions, solvents, emulsions, and syrups, and various excipients, such as water and liquid paraffin, which are commonly used simple diluents, may include, for example, wetting agents, sweeteners, fragrances, and preservatives. have.

Preferred dosages of the composition containing the alcohol extract of the flowering mushroom of the present invention vary depending on the condition and body weight, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art. Preferably, the drug containing the alcohol extract of the flowering mushroom of the present invention as an active ingredient is 0.0001 to 100 mg / kg per day based on the amount of the alcohol extract of the flowering mushroom, in order to be more effective 0.01 to 10 mg / It is recommended to administer in kg. The administration may be carried out once a day or divided into several doses. The dose and the number of administrations do not limit the scope of the present invention in any aspect.

According to another embodiment of the present invention, there is provided a functional food for the improvement or prevention of hyperlipidemia, comprising an alcohol extract of the flower shield mushroom as an active ingredient. As used herein, the term "health functional food" means a natural product or a processed product containing one or more nutrients, and preferably means a state in which it can be directly eaten through a certain processing process.

Examples of the health functional food to which the alcohol extract of the flower shield mushroom of the present invention can be added include various foods, beverages, gums, teas, vitamin complexes, and the like. In addition, the food in the present invention includes special nutritional products (e.g., prepared oils, infants, baby food, etc.), processed meat products, fish products, tofu, jelly, noodles (e.g. ramen, noodles, etc.), health supplements, seasoned foods ( For example, soy sauce, miso, red pepper paste, mixed soy sauce), sauces, confectionery (e.g. snacks), dairy products (e.g. fermented milk, cheese, etc.), other processed foods, kimchi, pickles (various kimchi, pickles, etc.), beverages ( Examples include, but are not limited to, fruits, vegetable drinks, soy milk, fermented beverages, and the like, and natural seasonings (eg, ramen soup). The food, beverage or food additive may be prepared by a conventional manufacturing method.

In the present specification, the functional food is a biological defense rhythm control, disease prevention and the like having a food group or food composition that has added value to the food by using physical, biochemical, biotechnological techniques, etc. to function and express the function of the food for a specific purpose. It means a food that is designed and processed to fully express the gymnastics function on recovery. The functional food may include a food-acceptable food-aid additive, and may further comprise suitable carriers, excipients and diluents conventionally used in the production of functional foods.

In the present specification, the beverage is a generic term for drinking to quench thirst or to enjoy a taste and is intended to include a functional beverage. The beverage contains, as an essential ingredient, an alcoholic extract of the flower packet mushroom as an essential ingredient as an active ingredient, and there are no special limitations on the other ingredients, and it contains various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks. can do. Examples of such natural carbohydrates include monosaccharides such as glucose, fructose and other disaccharides such as maltose, sucrose and the like and polysaccharides such as dextrin, cyclodextrin and the like, and Sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The ratio of the natural carbohydrate may be generally about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention, in addition to the composition of the present invention, natural fruit juice, fruit juice drink, vegetable drink It may further contain pulp for preparation.

In addition to the above, the health functional food of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid And salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, water, carbonation agents used in carbonated beverages, and the like. These components can be used independently or in combination. The ratio of such additives is not so important, but may be selected in the range of 0 to 20 parts by weight per 100 parts by weight of the alcohol extract of the flower mushroom of the present invention.

In the present specification, the functional beverage refers to a biological defense rhythm control, disease prevention, and the like having a beverage group or a beverage composition which has added value to the beverage by using physical, biochemical, or biotechnological techniques to act and express the function of the beverage to a specific purpose. Means a beverage that is designed and processed to fully express the gymnastics function related to recovery.

The functional beverage is not particularly limited to other ingredients except for containing the alcohol extract of the flower shield mushroom of the present invention as an essential ingredient in the ratio indicated, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks. Can be. Examples of such natural carbohydrates include monosaccharides such as glucose, fructose and other disaccharides such as maltose, sucrose and the like and polysaccharides such as dextrin, cyclodextrin and the like, and xylitol Sugar alcohols such as sorbitol and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of natural carbohydrates is generally about 1-20 g, preferably 5-12 g per 100 ml of the composition of the present invention.

In addition, in the health functional food for the purpose of improving or preventing hyperlipidemia, the amount of the extract may include 0.01 to 15% by weight of the total food weight, the beverage composition is 0.02 to 5 g based on 100 ml, preferably Preferably in a ratio of 0.3 to 1 g.

On the other hand, the present invention provides a method for producing an alcohol extract of the flower shield mushroom as described above according to another embodiment.

Method for producing a water extract of a flower shield mushroom according to an embodiment of the present invention comprises the steps of preparing a flower shield mushroom, mixing the flower shield mushroom with alcohol, the mixture at a temperature of 20 to 60 ℃, Extracting for 12 to 36 hours. The specific extraction time, extraction temperature and mixing ratio of the flower mushroom and the extraction solvent are replaced with the above.

The composition containing the alcohol extract of the flower shield mushroom of the present invention as an active ingredient may be usefully used for the treatment or prevention of hyperlipidemia by inhibiting the absorption of cholesterol and triglycerides in the body.

1 is a graph showing a comparison of the CEL activity inhibitory effect of the extracts of the flowers and mushrooms of Examples and Comparative Examples.
Figure 2 is a graph showing the TGL activity inhibitory effect of the extract of the flowers and mushrooms of Examples and Comparative Examples of the Examples and Comparative Examples.
Figure 3 is a graph showing a comparison of the amount of cholesterol absorption from the digestive tract of the alcohol extract of the flower shield mushroom according to an embodiment of the present invention and the conventional fat inhibitor orlistat from the digestive tract to the blood.
Figure 4 is a graph showing the comparison of the amount of triglyceride absorption into the blood from the digestive tract of the alcohol extract of the flower shield mushroom or Oratat, a conventional fat inhibitor according to an embodiment of the present invention.

Hereinafter, the configuration and effect of the present invention through the specific embodiments of the present invention will be described in more detail. However, the following examples are only intended to more clearly understand the invention, the scope of the invention is not limited to the following examples. Hereinafter, the present invention will be described in detail through examples of the present invention.

Example: Ethanol Extract Preparation of Flowering Mushroom

Per 5 g of dried Albatrellus dispansus powder, 100 ml of ethanol (99.9% (v / v)) was mixed with an extraction solvent, and extracted by placing in a shaker at 37 ° C for 24 hours. The supernatant of the shake incubator was collected after centrifugation at 2500 rpm for 10 minutes to prepare an ethanol extract of the flowering mushroom.

Comparative Example: Preparation of Water Extract of Flowering Mushroom

Except that 100 ml of water was used instead of ethanol as an extraction solvent, the water extract of the flowering mushroom was prepared in the same manner as in Example.

Experimental Example

One. Flower Shield Mushroom  Pancreatic Cholesterol by Extracts Ester raise  Active measurement

Pancreatic cholesterol esterase is responsible for separating acyl chain by non-specific recognition of substrates with acyl chain. In order to measure the activity of pancreatic cholesterol esterase by the flower extracts of Example and Comparative Example, posin pancreatic cholesterol esterase prepared from Sigma Chemical was used as an enzyme.

Pancreatic cholesterol esterase was used to decompose the chromo-genic substrate (p-nirophenylbutyrate) to determine the activity of the enzyme through the color reaction. The inhibitory effect of the enzyme was measured by the change of absorbance of 405 nm using a microplate reader and expressed in% based on the 405 nm absorbance of the untreated extract group.

It was measured how the activity of the enzyme is changed by the extracts of Examples and Comparative Examples, and as a result, it was confirmed that the ethanol extract of Example significantly lowered the activity of pancreatic cholesterol esterase. On the other hand, the water extract of the comparative example showed little effect of inhibiting the activity of pancreatic cholesterol esterase. The results are briefly shown in FIG.

2. Flower shield  Pancreas by Mushroom Extract Lipase  Active measurement

Pancreatic lipase is responsible for separating acyl chain by non-specific recognition of substrates with acyl chain. In order to measure pancreatic lipase activity by the flower extracts of the Examples and Comparative Examples, pocin pancreatic lipase type 2 (porcine pancreatic lipase; Type II, Sigma chemical) prepared from Sigma Chemical was used as an enzyme.

Pancreatic lipase was used to decompose the chromo-genic substrate (p-nirophenylbutyrate). The inhibitory effect of the enzyme was measured by the change of absorbance of 405 nm using a microplate reader and expressed in% based on the 405 nm absorbance of the extract untreated group.

It was determined how the activity of the enzyme is changed by the extracts of Examples and Comparative Examples, and as a result, it was confirmed that the ethanol extract of Example significantly lowered the activity of pancreatic lipase. On the other hand, the hydrothermal extract of Comparative Example showed little effect of inhibiting the activity of pancreatic lipase. The results are briefly shown in FIG.

3. Flower Shield Mushroom  Determination of Cholesterol Absorption by Ethanol Extracts

Cholesterol uptake in the digestive tract was measured to determine whether the ethanol extract of the flower patch of the example showing the inhibitory effect on cholesterol esterase activity was also effective at the individual level.

Raising the cholesterol labeled with isotopes ⁽³ H) benzoate (cholesterol oleate, Amersham, 100 μCi / ㎖) to 1% (w / v) carboxymethyl cellulose sodium (CMC-Na), 1% (v / v) Tween Twenty (mL) Tween 80, mixed with unlabeled cholesterol oleate, was forced to administer 0.1 ml via oral maximal administration to mice to contain 1 μCi per subject.

At this time, control mice (Balb / c male, 8 weeks old, weight ~ 25 g) to 400 μg (20 mg / kg) of Orlistat of cholesterol absorption inhibitory effect, experimental mice (Balb / c male, 8 weeks old, weight) ˜25 g) was concentrated with 20 ml of the ethanol extract (10 mg / ml) of the example of Rheum ulgaris, and 0.1 ml was orally administered.

After 6 hours, the blood of the mice was collected, the plasma was obtained by centrifugation at 4 ° C. at 14000 rpm for 10 minutes, and the dose was measured using a liquid scintillator (Beta counter, Beckman LS1801). The control group was a group that received nothing as a cholesterol inhibitor. The dose of the control group was set to 1, and the cholesterol absorption amount was determined as a relative value when the dose of each experimental group was divided by the dose of the control group.

The ethanol extract of the flower shield mushroom according to the present invention showed remarkable inhibition of cholesterol absorption similarly to the olistat used as the control group. The results are shown in FIG. For reference, the control in Figure 3 is the blood sampling results of the mice not administered anything as a cholesterol absorption inhibitor.

4. Flower Shield Mushroom  Measurement of Triglyceride Absorption by Ethanol Extracts

The fat uptake in the digestive tract was measured to determine whether the ethanol extract of Rhizoma cultivated in the pancreatic lipase activity was shown to be effective at the individual level.

Triolein (Amersham, 100 μCi / mL) labeled with isotope ( ¹⁴ C) was added to 1% (w / v) sodium carboxymethylcellulose (CMC-Na), 1% (v / v) Tween 80 (Ml) was mixed with (Tween 80) and the mice were forced to administer 0.1 ml via oral maximal administration to enter 1 μCi per subject.

In the control mice (Balb / c male, 8 weeks old, weight ~ 25 g), 400 μg (20 mg / kg) of Orlistat used as an anti-obesity agent, and experimental mice (Balb / c male, 8 weeks old, weight) ˜25 g) was concentrated to 0.5 ml of the ethanol extract (50 mg / ml) of the flower mushroom of the example, and 0.1 ml was orally administered.

After 6 hours, the blood of the mice was collected, the plasma was obtained by centrifugation at 4 ° C. at 14000 rpm for 10 minutes, and the dose was measured using a liquid scintillator (Beta counter, Beckman LS1801). The control group is the group that did not receive anything. The dose of the control group was set to 1, and the fat absorption amount was determined as a relative value when the dose of each experimental group was divided by the dose of the control group.

Ethanol extract of the flower shield mushroom according to the present invention showed a significant fat absorption inhibitory effect, but not as much as the olistat used as a control. The results are shown in Fig.

On the other hand, the following describes an example of the formulation using the ethanol extract of the flower shield mushroom of the present invention, the formulation of the present invention is not limited thereto.

Preparation Example: Formulation Using Ethanol Extract of Flower Shield Mushroom

Manufacturing example  One. Sanje  Produce

Flower ethanol extract powder 20 mg, lactose 100 mg, talc 10 mg.

The above ingredients were mixed and filled in an airtight container to prepare powders.

Manufacturing example  2. Preparation of tablets

Flower ethanol extract powder 10 mg, corn starch 100 mg, lactose 100 mg, magnesium stearate 2 mg.

After mixing the above components was prepared by tableting according to the conventional manufacturing method of the tablet.

Manufacturing example  3. Preparation of Capsule

Flower ethanol extract powder 10 mg, crystalline cellulose 3 mg, lactose 14.8 mg, magnesium stearate 0.2 mg.

The above components were mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.

Manufacturing example  4. Liquid  Produce

Flower shield mushroom ethanol extract powder 20 mg, isomerized sugar 10 g, mannitol 5 g, purified water appropriate amount.

According to the conventional method of preparing a liquid solution, each component is added to the purified water to dissolve it, and then the lemon flavor is appropriately added. The solution was prepared by sterilization.

Manufacturing example  5. Manufacture of Healthy Foods

Flower ethanol extract powder 1000 mg, vitamin mixture amount, vitamin A acetate 70 ㎍, vitamin E 1.0 mg, vitamin B1 0.13 mg, vitamin B2 0.15 mg, vitamin B6 0.5 mg, vitamin B12 0.2 ㎍, vitamin C 10 mg, biotin 10 μg, nicotinic acid amide 1.7 mg, folic acid 50 μg, calcium pantothenate 0.5 mg, mineral mixture appropriate amount, ferrous sulfate 1.75 mg, zinc oxide 0.82 mg, magnesium carbonate 25.3 mg, potassium monophosphate 15 mg, dicalcium phosphate 55 Mg, potassium citrate 90 mg, calcium carbonate 100 mg, magnesium chloride 24.8 mg.

The composition ratio of the above-mentioned vitamin and mineral mixtures is a composition suitable for a relatively healthy food in a preferred embodiment, but may be arbitrarily modified in combination, and the above ingredients are mixed according to a conventional health food manufacturing method. The granules may be prepared and used for preparing a health food composition according to a conventional method.

Claims (19)

A composition for treating or preventing hyperlipidemia comprising an alcohol extract of 1 to 10 carbon atoms of the flower shield mushroom as an active ingredient. The composition of claim 1, wherein the alcohol is an alcohol having 1 to 5 carbon atoms. The composition of claim 1, wherein the alcohol is ethanol. The composition of claim 3, wherein the ethanol is 90 to 99.9% (v / v). The composition according to any one of claims 1 to 4, wherein the extract is extracted with 90 to 99.9% (v / v) ethanol for 12 to 36 hours at a temperature of 20 to 60 ℃. The composition according to any one of claims 1 to 4, wherein the extract is obtained by mixing 0.1 to 20 g of flower mushrooms per 100 ml of alcohol having 1 to 10 carbon atoms. The composition according to any one of claims 1 to 4, wherein the composition comprises 0.001 to 50% by weight of an alcohol extract having 1 to 10 carbon atoms. The composition according to any one of claims 1 to 4, wherein the extract inhibits the absorption of cholesterol and / or triglycerides. The composition according to any one of claims 1 to 4, wherein the extract lowers the activity of pancreatic cholesterol esterase and / or the activity of pancreatic lipase. A drug for treating or preventing hyperlipidemia comprising an alcohol extract of 1 to 10 carbon atoms of the flower shield mushroom as an active ingredient. The pharmaceutical product of claim 10, wherein the medicine is a powder, granules, tablets, suspensions, emulsions, or syrups. Health functional food for improving or preventing hyperlipidemia comprising an alcohol extract of 1 to 10 carbon atoms of the flower shield mushroom as an active ingredient. The health functional food of claim 12, wherein the health functional food is a food, a food additive, or a beverage. The health functional food according to claim 12 or 13, wherein the health functional food inhibits the absorption of cholesterol and / or triglycerides. The health functional food according to claim 12 or 13, wherein the health functional food lowers the activity of pancreatic cholesterol esterase and / or the activity of pancreatic lipase. A method of treating or preventing hyperlipidemia, comprising administering a pharmaceutically effective amount of an alcohol extract having 1 to 10 carbon atoms of a flowering mushroom to an animal except a human. Alcoholic extract of flowering mushrooms, characterized by inhibiting the absorption of cholesterol and / or triglycerides in the blood. 18. The extract of claim 17, wherein the extract lowers the activity of pancreatic cholesterol esterase and / or the activity of pancreatic lipase. 19. The extract according to claim 17 or 18, wherein the extract is obtained by extracting the flowering mushrooms with 90 to 99.9% (v / v) of ethanol for 12 to 36 hours at a temperature of 20 to 60 ℃.

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