KR20120126749A - Composition Comprising Alcohol Extracts from Sparassis cripspa Wulfen Fr. for Treating or Preventing Obesity - Google Patents

Abstract

PURPOSE: A composition containing Sparassis crispa Wulf.ex Fr. alcohol extract for preventing or treating obesity and a health functional food containing the same are provided to suppress digestion and absorption of body fat. CONSTITUTION: A composition for preventing or treating obesity contains Sparassis crispa Wulf.ex Fr. alcohol extract as an active ingredient. The extract is prepared by extracting Sparassis crispa Wulf.ex Fr. with 90-99.9%(v/v) of ethanol at 20-60 Deg. C. for 12-36 hours. The composition contains 0.001-50 wt% of the extract. A pharmaceutical product for preventing or treating obesity contains the extract as an active ingredient. The pharmaceutical product is powder, granules, tablet, suspension, emulsion, or syrup. A helath functional food for treating or preventing obesity contains the extract as an active ingredient. The extract is prepared using an alcohol of 1-10 carbon numbers. [Reference numerals] (AA) TGL activity inhibition(%); (BB) Comparative embodiment(water extract); (CC) Ethanol extract

Description

Composition or treatment for prevention of obesity comprising alcohol extract of zinnia mushroom {Composition Comprising Alcohol Extracts from Sparassis cripspa Wulfen Fr. for Treating or Preventing Obesity}

The present invention relates to a composition comprising an alcohol extract of a zinnia mushroom that can be used for the treatment or prevention of obesity.

Obesity is a condition in which fat tissue is excessively accumulated in the body. Obesity is known to be the leading cause of cardiovascular disease, type 2 diabetes, colorectal cancer, rectal cancer, prostate cancer, breast cancer, ovarian cancer, etc. (Haslam DW, James WP, 2005, "Obesity". Lancet 366 (9492): 1197-209). The obesity population in Korea is also increasing steadily, and the global increase in childhood obesity is tripled every 10 years, which is expected to cause more adult obesity. Many reports on the treatment, prevention and prescription of obesity have been presented. (Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E (April 2007), "2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]". CMAJ 176 (8) : S1-13., Wada K, Ikeda Y .: Longitudinal studies to determine the effect of body fat rate reduction on blood pressure.J Med Sys 22: 19-25 (1998)).

The most common cause of obesity is excessive calorie intake and lack of exercise, which results from the accumulation of excess energy sources in the form of fat in the body (Bray GA, Popkin BM .: Dietary fat intake dose affect obesity. Clin.Nutr 68: 1157-1173 (1998). In particular, increased consumption of high-fat diets due to westernized diets is considered the main reason for obesity. Currently, the development of anti-obesity agonists for the prevention or treatment of obesity is being actively conducted worldwide, and accordingly, interest in the anti-obesity efficacy evaluation model is also increasing.

Currently, obesity treatment drugs act directly on the neurotransmitter or hormone system such as appetite suppressants, energy metabolism promoters, hormone and peptide regulators, and non-central nervous system peptides to give satiety or directly inhibit appetite and digestive enzymes. Indirect drugs that inhibit are largely divided into two types.

On the other hand, drugs that directly affect the neurotransmitter or hormone system to give satiety or suppress appetite may cause side effects such as increased blood pressure, insomnia, sweating, and lethargy. Due to such problems, recently, attention has been focused on fat absorption inhibitors that act on digestive enzymes and inhibit fat absorption through food. Xenical ™ (orlistat) is well known as a drug having such a mechanism of action, and forms a covalent bond with serine, an active site of triglyceride lipase (TGL), to inhibit lipase activity. Fat absorption inhibitors have minimal systemic absorption and act only locally on the gastrointestinal tract, so there are no central nervous system side effects. Due to these advantages, the obesity treatment market of fat-inhibiting family continues to grow every year.

On the other hand, about 10,000 species of mushrooms have been reported around the world, and because of their high edible and medicinal value, many studies have been conducted in developed countries such as Europe, the United States, and Japan to secure them as useful resources for microorganisms. In particular, many studies have reported that physiologically active substances produced by mushrooms are safe in terms of toxicity due to less side effects and have various functions such as regulation of immune system function, anticancer effect and metabolism in human body.

The inventors of the present invention have completed the present invention while researching a natural substance having almost no side effects in vivo and having an anti-obesity effect by inhibiting digestion and absorption of fat in the body.

Accordingly, the present invention provides a composition and a medicine and a health functional food comprising the same, which show little or no side effects in vivo, inhibit digestion and absorption of fat in the body, and exhibit a therapeutic or prophylactic effect of obesity.

In order to achieve the above object, the present invention provides a therapeutic or prophylactic composition of obesity comprising an alcohol extract of 1 to 10 carbon atoms of the blossom mushroom as an active ingredient.

In another aspect, the present invention provides a drug for the treatment or prevention of obesity comprising an alcohol extract of 1 to 10 carbon atoms of the blossom mushroom.

And the present invention provides a functional food for the improvement or prevention of obesity comprising an alcohol extract of 1 to 10 carbon atoms of the blossom mushroom as an active ingredient.

The present invention provides a composition for treating or preventing obesity, comprising an alcoholic extract having 1 to 10 carbon atoms as an active ingredient of a blossom mushroom.

The flower mushroom (Sparassis crispa Wulf.ex Fr., Japanese name Hanabiratake) is a mushroom of the Democratic Mushrooms of the mushroom family, pine, pine, larch, beech, buckwheat, etc. It is a brownish brownish mushroom that grows on the ground or on the stump near the root of the root. Flower mushrooms are distributed in Korea, Japan, China, North America, Europe, Australia, and are edible mushrooms. They are chewy and smell like pine mushrooms.

These blossom mushrooms are known to contain a variety of active ingredients, relatively rich in protein, vitamins B1, B2, D, as well as minerals, such as calcium, iron, sodium is known to contain abundant.

The inventors of the present invention as a natural substance that can replace a drug such as Xenical ™ (orlistat), while studying the fat absorption inhibitors that act on digestive enzymes to inhibit fat absorption through food, extracts of blossom mushrooms, In particular, the alcohol extract of the mushroom mushroom was found to effectively inhibit the activity of gastrointestinal lipase (Triglyceride lipase, TGL) to complete the present invention.

At this time, the C1-C10 alcohol extract of the flower mushroom may be extracted by using a C1-C5 low-cost alcohol as the extraction solvent. The inventors of the present invention were able to confirm that the body fat is more excellent in digestion and absorption inhibitory effect when extracting the blossom mushroom with a low-cost alcohol having 1 to 5 carbon atoms.

In particular, as such an alcohol extraction solvent, a low-cost alcohol having 1 to 5 carbon atoms, more preferably ethanol, and most preferably 90% to 99.9% (v / v) ethanol can be used. In the case of the alcohol extract of the flower mushroom extracted using such an extraction solvent, it was found that the effect of inhibiting the digestion and absorption of fat and the effect of reducing the amount of fat absorption into the blood from the digestive tract are apparent.

On the other hand, the alcohol extract of the flower mushroom as described above may be prepared according to the conventional method for producing a plant extract. Preferably, after drying and pulverizing the mushroom mushroom, the residue is removed, and then 0.1 to 20 g of the pulverized substance is added per 100 ml of alcohol having 1 to 10 carbon atoms, more preferably 1 to 5 g of the pulverized substance per 100 ml of the extraction solvent. Can be added and extracted. If the content of the crushed mushroom mushroom is too small compared to the extraction solvent, it is not preferable because the effect of the blossom mushroom is not sufficiently achieved. If the content of the extract is too large compared to the amount of the extracting solvent, the effect of increasing the content is not large, but the production cost is low. As it increases, it is undesirable in terms of productivity.

At this time, the extraction conditions are not limited in configuration, but preferably after mixing the mushroom mushrooms with alcohol having 1 to 10 carbon atoms as the extraction solvent, at a temperature of 20 to 60 ℃, 12 to 36 hours, more preferably 30 to At a temperature of 40 ° C. it can be extracted for 20 to 24 hours.

When the extraction is performed at an excessively low temperature condition, a long time is required for the extraction of the effective extraction component, and when the extraction is performed at an excessively high temperature condition, the activity may be degraded, which is not preferable.

When the extraction time is too short, the concentration of the active ingredient to be extracted is low, and when extraction for an excessively long time, the increase in concentration of the extraction active ingredient with the increase of the extraction time is insignificant, which is not preferable in terms of productivity.

In addition, the alcohol extract of the flower mushroom extracted by the above method is filtered through a filter cloth, etc., the filtrate is centrifuged to remove the precipitate, and then concentrated under reduced pressure or concentrated, and then freeze-dried.

On the other hand, the content of the alcohol extract of zinnia mushroom as an active ingredient in the treatment or prevention composition of obesity of the above-described embodiment is not limited, but may preferably be 0.001 to 50% by weight. When the content of the alcohol extract of the blossoming mushroom, which is an active ingredient, is less than 0.001% by weight, the digestive absorption and inhibition effect of fat in the body is insignificant, and when it exceeds 50% by weight, the effect of increasing the inhibitory activity by increasing the content is insignificant. Not

More preferably, the content of the alcohol extract of the blossom mushroom in the composition may be 0.01 to 50% by weight, most preferably 0.1 to 30% by weight.

The present invention provides a medicament for the treatment or prevention of obesity comprising an alcohol extract of the zinnia mushroom contained in the composition as an active ingredient. Medicines containing an alcohol extract of such a mushroom mushroom as an active ingredient may further comprise a suitable carrier, excipients and diluents commonly used in the preparation thereof.

Carriers, excipients and diluents that may be included in the pharmaceutical preparations containing the alcohol extract of the zinnia mushroom as an active ingredient include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate , Gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.

Medicines containing the alcohol extract of the blossom mushroom of the present invention as an active ingredient may be used in oral formulations, such as powders, granules, tablets, suspensions, emulsions, syrups, etc. according to conventional methods.

The oral formulation is meant to include a solid preparation and a liquid preparation for oral administration, the solid preparation for oral administration may include tablets, pills, powders, granules, capsules, etc., such solid preparation is the extract At least one excipient, for example, may be prepared by mixing starch, calcium carbonate, sucrose or lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral use include suspensions, solvents, emulsions, and serums.In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have.

Preferred dosages of the compositions containing the alcohol extracts of the Zinnia mushroom of the present invention vary depending on the condition and weight, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art. Preferably, the drug containing the alcohol extract of the blossom mushroom of the present invention as an active ingredient is 0.0001 to 100mg / kg per day based on the amount of the alcohol extract of the blossom mushroom is administered to 0.01 to 10mg / kg to be more effective It is good. The administration may be carried out once a day or divided into several times. The dose and the number of administrations do not limit the scope of the present invention in any aspect.

According to another embodiment of the present invention, there is provided a functional food for the improvement or prevention of obesity comprising an alcohol extract of the mushroom mushroom as an active ingredient. As used herein, the term "health functional food" means a natural product or a processed product containing one or more nutrients, and preferably means a state in which it can be directly eaten through a certain process.

Examples of the health functional food to which the alcohol extract of the blossom mushroom of the present invention can be added include various foods, beverages, gums, teas, vitamin complexes, and the like. In addition, the food in the present invention includes special nutritional products (e.g., prepared oils, infants, baby food, etc.), processed meat products, fish products, tofu, jelly, noodles (e.g. ramen, noodles, etc.), health supplements, seasoned foods ( For example, soy sauce, miso, red pepper paste, mixed soy sauce), sauces, confectionery (e.g. snacks), dairy products (e.g. fermented milk, cheese, etc.), other processed foods, kimchi, pickles (various kimchi, pickles, etc.), beverages ( Examples include, but are not limited to, fruits, vegetable drinks, soy milk, fermented beverages, and the like, and natural seasonings (eg, ramen soup). The food, beverage or food additive may be prepared by a conventional production method.

In the present specification, the functional food is a biological defense rhythm control, disease prevention and the like having a food group or food composition that has added value to the food by using physical, biochemical, biotechnological techniques, etc. to function and express the function of the food for a specific purpose. It means a food that is designed and processed to fully express the gymnastics function on recovery. The functional food may include a food-acceptable food-aid additive, and may further comprise suitable carriers, excipients and diluents conventionally used in the production of functional foods.

In the present specification, the beverage is a generic term for drinking to quench thirst or to enjoy a taste and is intended to include a functional beverage. The beverage contains, as an essential ingredient, an alcoholic extract of the zinnia mushroom as an active ingredient, as an active ingredient, and there are no special limitations on the other ingredients, and it may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks. Can be. Examples of such natural carbohydrates include monosaccharides such as glucose, fructose and other disaccharides such as maltose, sucrose and the like and polysaccharides such as dextrin, cyclodextrin and the like, and Sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The ratio of the natural carbohydrate may generally be about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention. It may further contain a pulp for.

In addition to the above, the health functional food of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid And salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. These components can be used independently or in combination. The proportion of such additives is not so critical, but may be selected in the range of 0 to 20 parts by weight per 100 parts by weight of the alcohol extract of the blossom mushroom of the present invention.

In the present specification, the functional beverage refers to a biological defense rhythm control, disease prevention, and the like having a beverage group or a beverage composition which has added value to the beverage by using physical, biochemical, or biotechnological techniques to act and express the function of the beverage to a specific purpose. Means a beverage that is designed and processed to fully express the gymnastics function related to recovery.

The functional beverage is not particularly limited in addition to the alcohol extract of the zinnia mushroom of the present invention as an essential ingredient in the indicated ratio, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks. have. Examples of such natural carbohydrates include monosaccharides such as glucose, fructose and other disaccharides such as maltose, sucrose and the like and polysaccharides such as dextrin, cyclodextrin and the like, and xylitol Sugar alcohols such as sorbitol and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of natural carbohydrates is generally about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention.

In addition, in the health functional food for the purpose of improving or preventing obesity, the amount of the extract may include 0.01 to 15% by weight of the total food weight, the beverage composition is 0.02 to 5 g based on 100 ml, preferably Preferably it may be included in a ratio of 0.3 to 1g.

On the other hand, the present invention provides a method for producing an alcohol extract of the blossom mushroom according to another embodiment.

Method for producing an alcohol extract of the blossom mushroom according to an embodiment of the present invention comprises the steps of preparing a blossom mushroom; Mixing the blossom mushroom with an alcohol having 1 to 10 carbon atoms; And extracting the mixture at a temperature of 20 to 60 ° C. for 12 to 36 hours.

On the other hand, in the method for producing an alcohol extract of 1 to 10 carbon atoms of the flower mushroom according to the above embodiment, the alcohol is an alcohol having 1 to 5 carbon atoms, more preferably ethanol, most preferably 90% to 99.9% (v / v) ethanol. When extracted with such an extraction solvent, it was found that the effect of reducing the amount of fat absorption from the digestive tract to the blood as well as the effect of inhibiting the digestion and absorption of fat of the extracted extract.

The specific extraction time, extraction temperature, and mixing ratio of the flower mushroom and the extraction solvent are replaced with those described above.

The composition comprising an alcohol extract of the zinnia mushroom as an active ingredient may be usefully used for the treatment or prevention of obesity by inhibiting the digestion and absorption of fat in the body.

1 is a graph showing a comparison of the inhibitory effect of the TGL activity of the alcohol extract of the blossom mushroom of the Example and Comparative Example.
Figure 2 is a graph showing a comparison of the inhibitory effect of TGL activity according to the extract concentration of the ethanol extract of zinnia mushroom (in Figure 2, 1x frozen 1ml amount extracted at 37 ℃ 24 hours at a concentration of 10mg / ml in 99.9% ethanol 24 hours) Means dry).
Figure 3 is a graph showing the amount of fat absorption into the blood from the digestive tract of the ethanol extract of the flower mushroom according to an embodiment of the present invention and orlistat, a conventional fat inhibitor.

Hereinafter, the configuration and effect of the present invention through the specific embodiments of the present invention will be described in more detail. However, the following examples are only intended to more clearly understand the invention, the scope of the invention is not limited to the following examples. Hereinafter, the present invention will be described in detail through examples of the present invention.

[ Example Ethanol Extract Preparation of Blossom Mushroom

For every 5 g of powder of dried blossom mushroom (Sparassis crispa Wulf.ex Fr., purchased by Hana Biotech), 100 ml of ethanol (99.9% (v / v)) is mixed with the extraction solvent and then shaken at 37 ° C for 24 hours. Extracted a couple. The supernatant of the shaker was collected after centrifugation at 2500 rpm for 10 minutes to prepare an ethanol extract of the zinnia mushroom.

[ Comparative example Of the mushroom mushroom Heat number  Extract preparation

A hydrothermal extract of the Zinnia mushroom was prepared in the same manner as in Example except that 100 ml of water was used instead of 100 ml of ethanol (99.9% (v / v)) as an extraction solvent.

[ Experimental Example ]

1. Measurement of Pancreatic Lipase Activity by the Extracts of the Flower of Mushroom

Pancreatic lipase is responsible for separating acyl chain by non-specific recognition of substrates with acyl chain. In order to measure pancreatic lipase activity by the flower extract of the flower of Example and Comparative Example, posin pancreatic lipase type 2 (Porcine pancreatic Lipase; Type II, Sigma chemical) manufactured by Sigma Chemical was used as an enzyme.

Pancreatic lipase was used to decompose the chromo-genic substrate (p-nirophenylbutyrate). The inhibitory effect of enzyme was measured by the change in absorbance of 405nm using a microplate reader, and calculated based on the 405nm absorbance of the extract untreated group and expressed as%.

It was determined how the activity of the enzyme is changed by the extracts of Examples and Comparative Examples, and as a result, it was confirmed that the ethanol extract of Example significantly lowered the activity of pancreatic lipase.

On the other hand, the hydrothermal extract of Comparative Example showed little effect of inhibiting the activity of pancreatic lipase. The results are briefly shown in FIG.

As shown in FIG. 1, the composition according to the comparative example of the hydrothermal extract of the zinnia mushroom showed little effect of inhibiting TGL activity, but the TGL of the alcohol extract of the zinnia mushroom with 99.9 (v / v)% ethanol as the extraction solvent It was found that the activity inhibitory effect was excellent.

2. Measurement of Pancreatic Lipase Activity According to the Concentration of Ethanol Extracts of Blossom Mushroom

On the other hand, pancreatic lipase activity was measured according to the concentration of the ethanol extract of the zinnia mushroom of the example. Compared to the effect of inhibiting pancreatic lipase activity when the amount of the ethanol extract of the blossoming mushroom treated with pancreatic lipase was increased by 2 times 3 times, 4 times, and 5 times based on the initial flower powder concentration (1%), The results are shown in FIG.

3. Measurement of Fat Absorption by Blossom Mushroom Extracts

Fat uptake in the digestive tract was measured to determine whether the ethanol extract of the zinnia mushroom of the example showing the effect of inhibiting pancreatic lipase activity was also effective at the individual level.

Triolein (Amersham, 100 μCi / ml) labeled with isotope ( ¹⁴ C) was added 1% (w / v) sodium carboxymethylcellulose (CMC-Na), 1% (v / v) Tween 80 (Ml) was mixed with (Tween 80) and forced to administer 0.1 ml via an oral bandage to mice containing 1 μCi per subject.

In the control mice (Balb / c male, 8 weeks old, weight ~ 25g), 400 μg (20mg / kg) of Orlistat used as an anti-obesity agent, experimental mice (Balb / c male, 8 weeks old, weight ~ 25g) ), 0.5 ml of the ethanol extract (50 mg / ml) of the zinnia mushroom was concentrated and administered 0.1 ml orally.

After 6 hours, the blood of the mice was collected, the plasma was obtained by centrifugation at 14000 rpm for 10 minutes at 4 ° C, and the dose was measured using a liquid scintillator (Beta counter, Beckman LS1801). The control group was the group that received nothing as a treatment for obesity. The dose of the control group was set to 1, and the fat absorption amount was determined as a relative value when the dose of each experimental group was divided by the dose of the control group.

Alcohol extract of the blossom mushroom according to the present invention showed a significant fat absorption inhibitory effect like the olistat used as a control. The results are shown in FIG. For reference, in FIG. 3, the control is the blood sampling result of the mice administered nothing with the anti-obesity agent.

On the other hand, the following describes an example of the formulation using the alcohol extract of the blossom mushroom of the present invention, but the formulation of the present invention is not limited thereto.

[ Manufacturing example  : Formulation Using Blossom Mushroom Extract]

Manufacturing example  One. Sanje  Produce

Blossom Mushroom Alcohol Extract Powder 20 mg

Lactose 100 mg

Talc 10 mg

The above ingredients were mixed and filled in an airtight cloth to prepare a powder.

Manufacturing example  2. Preparation of tablets

Blossom Mushroom Alcohol Extract Powder 10 mg

Corn starch 100 mg

Lactose 100 mg

2 mg magnesium stearate

After mixing the above components was prepared by tableting according to the conventional manufacturing method of the tablet.

Manufacturing example  3. Preparation of Capsule

Blossom Mushroom Alcohol Extract Powder 10 mg

3 mg of crystalline cellulose

Lactose 14.8 mg

Magnesium Stearate 0.2 mg

According to a conventional capsule preparation method, the above ingredients were mixed and filled into gelatin capsules to prepare capsules.

Manufacturing example  4. Liquid  Produce

Blossom Mushroom Alcohol Extract Powder 20 mg

10 g of isomerized sugar

5 g of mannitol

Purified water quantity

After dissolving each component in purified water according to the usual method of preparing a liquid solution, adding lemon flavor appropriately, mixing the above components, adding purified water, adjusting the whole to 100 ml by adding purified water, and then filling into a brown bottle. The solution was prepared by sterilization.

Manufacturing example  5. Manufacture of Healthy Foods

Blossom Mushroom Alcohol Extract Powder 1000mg

Vitamin mixture proper amount

70 μg of Vitamin A Acetate

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

Vitamin B2 0.15 mg

Vitamin B6 0.5 mg

0.2 μg of vitamin B12

Vitamin C 10 mg

10 μg biotin

Nicotinic Acid 1.7 mg

50 μg folic acid

Calcium Pantothenate 0.5mg

Mineral mixture

Ferrous Sulfate 1.75 mg

Zinc Oxide 0.82 mg

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Dibasic calcium phosphate 55 mg

Potassium Citrate 90 mg

Calcium Carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.

Claims (11)

A therapeutic or prophylactic composition for obesity comprising an alcohol extract of 1 to 10 carbon atoms of the zinnia mushroom as an active ingredient. The method of claim 1,
The alcohol is a composition having 1 to 5 carbon atoms. The method of claim 1,
Wherein said alcohol is ethanol. The method of claim 3, wherein
The ethanol is 90% to 99.9% (v / v) composition. The method of claim 1,
The extract is a composition that is extracted from the zinnia mushroom with a ethanol of 90% to 99.9% (v / v) at a temperature of 20 to 60 ℃, for 12 to 36 hours. The method of claim 1,
The extract is a composition that is extracted by mixing 0.1 to 20g of mushroom mushrooms per 100ml of alcohol having 1 to 10 carbon atoms. The method of claim 1,
A composition comprising 0.001 to 50% by weight of an alcohol extract having 1 to 10 carbon atoms of the zinnia mushroom. Drugs for the treatment or prevention of obesity comprising an alcohol extract of 1 to 10 carbon atoms of the flower mushroom as an active ingredient. The pharmaceutical product of claim 8, wherein the medicine is a powder, granules, tablets, suspensions, emulsions, or syrups. Health functional food for the improvement or prevention of obesity comprising an alcohol extract of 1 to 10 carbon atoms of the flower mushroom as an active ingredient. The health functional food of claim 10, wherein the health functional food is a food, a food additive or a beverage.

Images