KR101795261B1 - Medicinal-Herb Composition Comprising Chinese matrimony vine for Treatmenting and Protecting the Insomniac and the Method of Making the Same - Google Patents

Medicinal-Herb Composition Comprising Chinese matrimony vine for Treatmenting and Protecting the Insomniac and the Method of Making the Same Download PDF

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KR101795261B1
KR101795261B1 KR1020160064766A KR20160064766A KR101795261B1 KR 101795261 B1 KR101795261 B1 KR 101795261B1 KR 1020160064766 A KR1020160064766 A KR 1020160064766A KR 20160064766 A KR20160064766 A KR 20160064766A KR 101795261 B1 KR101795261 B1 KR 101795261B1
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betaine
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이경훈
황동석
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(주)비아바이오텍
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/38Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • AHUMAN NECESSITIES
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732Chaenomeles, e.g. flowering quince
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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Abstract

The present invention relates to an oriental herbal medicine composition which has an effect of improving liver functions by comprising active ingredients of Lycium chinense, Chinese quince, Eleutherococcus sessiliflorus, Cornus officinalis, Actinidia polygama, Phragmites australis, green tea, onions, Zizyphus jujuba Mill var. inermis Rehder, Valeriana officinalis L. extract powder, brewers yeast, chicken sternum cartilage powder, honey, betaine, Hovenia dulcis extract powder, and red ginseng; and to a preparation method of the same. The oriental herbal medicine composition comprising Lycium chinense of the present invention comprises: 1-30 parts by weight of Lycium chinense; 1-30 parts by weight of Chinese quince; 1-20 parts by weight of Cornus officinalis; 1-20 parts by weight of betaine; 1-10 parts by weight of red ginseng; 1-10 parts by weight of Hovenia dulcis extract powder; 1-30 parts by weight of honey; 1-30 parts by weight of Actinidia polygama fruits; 1-20 parts by weight of brewers yeast; 1-20 parts by weight of Zizyphus jujuba Mill var. inermis Rehder; 1-20 parts by weight of Phragmites australis; 1-20 parts by weight of green tea; 1-20 parts by weight of Eleutherococcus sessiliflorus; 1-20 parts by weight of Valeriana officinalis L. extract powder; 1-20 parts by weight of chicken sternum cartilage powder; and 1-10 parts by weight of onions. Additionally, the present invention provides a preparation method of an oriental herbal medicine composition comprising Lycium chinense for improving liver functions. According to the present invention, the oriental herbal medicine composition may be beneficially used to improve liver functions by comprising effective components including Lycium chinense, Chinese quince, and Valeriana officinalis L. extract.

Description

구기자를 포함하는 간 기능 개선용 한방조성물 및 그 제조방법{Medicinal-Herb Composition Comprising Chinese matrimony vine for Treatmenting and Protecting the Insomniac and the Method of Making the Same}TECHNICAL FIELD The present invention relates to a herbal composition for improving liver function and a method for preparing the same, and a medicinal herb composition and method for preparing the same,

본 발명은 구기자를 포함하는 간 기능 개선용 한방조성물 및 그 제조방법에 관한 것으로서, 보다 상세하게는 구기자, 모과나무, 오갈피나무, 산수유, 개다래나무, 갈대, 녹차, 양파, 대추, 발레리안 추출분말, 맥주 효모, 닭흉부연골추출분말, 꿀, 베타인, 헛개나무 추출분말 및 홍삼의 유효성분을 포함함으로써, 간 기능 개선에 유용한 한방 조성물 및 그 제조 방법에 관한 것이다.The present invention relates to a herbal composition for improving liver function and a method of preparing the same, and more particularly, to a herbal composition for improving liver function including gugija, and more particularly to a herbal composition for improving liver function including gugija, quince tree, oak tree, , Brewer's yeast, chest chest cartilage extract powder, honey, betaine, hinoki extract powder and red ginseng effective ingredient for improving liver function and a method for preparing the same.

한의학적 용어인 간장혈[肝藏血]이란 혈이 간에 충분히 저장되는 상태를 말하며 한의학에서는 이 상태에서 수면이 가능하다고 한다. 급격히 현대사회로 변화되면서 우리 몸의 생활 습관도 변화되었고, 도시 생활 패턴은 24시간이 부족할 만큼 빠르고 바쁘게 움직인다. 그에 반해 간(肝)은 공복이거나 잠을 잘 때 재충전의 시간을 가지는데, 이런 현대 습관들은 해독기능과 더불어 고급적 2차 기능 활성화에도 영향을 미치게 된다. 호르몬 대사 등과 같은 간의 고급기능들은 더욱이 소화기에 음식이 없고 신체활동이 최소화되었을 때, 혹은 잠을 충분히 잘 때 활발한 기능을 하게 됩니다. 더욱이 과중한 업무와 스트레스에 시달리는 직장인들이나, 잦은 야근 및 회식을 하는 집단들은 특성상 음주, 야식 등으로 신체 불균형 위험에 노출되기 쉽다.The term "hepatopathic blood", a Chinese medicine term, refers to a state in which blood is sufficiently stored in the liver, and in Oriental medicine, sleep is possible in this state. As our society has rapidly changed into a modern society, our lifestyles have changed, and our urban life patterns are fast and busy, lacking 24 hours. On the other hand, the liver has time to recharge when it is fasting or sleeping, and these modern habits also affect the activation of advanced secondary functions in addition to detoxification. Hormone metabolism, etc., are also more active when the digestive system is free of food, physical activity is minimized, or sleep is full. Moreover, workers who suffer from heavy work and stress, frequent night shifts, and frequent groups are more likely to be exposed to physical imbalance due to drinking and night work.

간(肝)은 우리 몸에 흡수되는 모든 음식물을 간에서 해독작용을 하고 영양소을 간에서 저장하며 담즙과 같이 분비되어 혈류를 조절하는 등 중요한 역할을 한다. 만약, 간기능이 떨어지면 GOT, GPT, GTP(감마지티)가 상승하게 되고, 노폐물이나 독소가 잘 배출되지 않아, 각종 합병증(간성 혼수, 복수, 식도정맥류, 혈소판 감소증)이 올 수가 있고 식욕부진, 복부팽만감(등) 두통, 잇몸 출혈이 생긴다. 간은 침묵의 장기이라고 불리는 만큼 자가 진단이 쉽지 않다. The liver plays an important role in detoxifying all foods that are absorbed by the body, storing nutrients in the liver, and being secreted like bile to regulate blood flow. If the liver function is low, GOT, GPT, GTP (Gamma jittii) will rise, and waste products and toxins will not be discharged well. Various complications (hepatic coma, ascites, esophageal varices, thrombocytopenia) Abdominal bloating (etc.) Headache, gum bleeding occurs. The liver is called the organ of silence, so self-diagnosis is not easy.

시중에서 간기능 개선제, 간에 효과가 있는 의약품, 음료, 건강기능식품들이 출시되고 있는 상황이지만, 음주나 간기능과 관련된 직접적인 기능을 하는 효소 수치에 중점을 두고 있다. 수면과 간기능은 밀접하게 연결되어 있으며 염증은 그런 불균형이 초래하는 생체반응들이다. 해독 작용 및 새로운 세포를 만드는데 필요한 성분들을 섭취하여 수면의 질을 높이고 간의 고급적 기능을 활성화시키는데 도움을 주며 이에 수면기능과 간기능을 동시에 효과가 있도록 하는 조성물을 제공하고 나아가 염증성 반응을 억제할 수 있는 생약을 이용한 천연의약품에 대한 필요성이 대두되고 있다. On the market, medicines, beverages, and health functional foods with liver function are on the market, but they focus on enzymes that directly function in relation to drinking and liver function. Sleep and liver function are closely linked, and inflammation is a biological reaction caused by such an imbalance. Detoxification and new cell formation to enhance the quality of sleep and to activate the advanced functions of the liver, thereby providing a composition that has both sleeping function and liver function at the same time, and can further inhibit the inflammatory response The need for natural medicines using herbal medicines is emerging.

본 발명자들은 간기능, 염증, 알러지를 개선하고 치료에 유용한 구기자, 모과나무, 오갈피나무, 산수유, 개다래나무, 갈대, 녹차, 양파, 대추, 발레리안 추출분말, 맥주 효모, 닭흉부연골추출분말, 꿀, 베타인, 헛개나무 추출분말 및 홍삼을 함유하는 조성물을 완성하고 이 제제가 간기능 개선과 치료에 사용될 수 있음을 확인하여 본 발명을 완성하게 되었다.The inventors of the present invention have found that the extract of chrysanthemum chrysanthemum extract, which is useful for improving liver function, inflammation, and allergy, and which is useful for treatment, such as Gugija, Quercus mongolica, Ogakkii, Maruchis japonica, Reed, Green tea, Onion, Jujube, Valerian extract powder, The present inventors completed the present invention by confirming that the composition containing honey, betaine, hinoki extract powder and red ginseng can be used for improving and treating liver function.

본 발명은 상기 한방 조성물을 함유하는 간기능 개선용 약제학적 조성물, 식품 조성물 및 건강기능식품 조성물을 제공하는 것에 그 목적이 있다. It is an object of the present invention to provide a pharmaceutical composition for improving liver function, a food composition and a health functional food composition containing the herbal composition.

따라서, 본 시험은 세포주를 가지고 간기능에 효과가 있을 것으로 예상되는 한방 복합제제의 간기능 개선효능을 관찰함으로써 향후 간기능 개선효능 치료 약물로서의 개발 가능성을 평가하고자 하였다.Therefore, the present study was conducted to evaluate the possibility of development as a liver function improving efficacy therapeutic drug by observing the liver function improving effect of a herbal composition which is expected to have an effect on liver function with a cell line.

등록특허 제10-1292931호 : 백운풀 추출물을 유효성분으로 포함하는 비알콜성 지방간질환의 예방 또는 치료용 조성물Registration No. 10-1292931: A composition for preventing or treating non-alcoholic fatty liver disease comprising an acne extract as an active ingredient

상기와 같은 문제점을 해결하기 위한 본 발명의 목적은 구기자, 모과나무, 오갈피나무, 산수유, 개다래나무, 갈대, 녹차, 양파, 대추, 발레리안추출분말, 맥주 효모, 닭흉부연골추출분말, 꿀, 베타인, 헛개나무 추출분말 및 홍삼을 함유하는 간 기능 개선용 한방 조성물 및 그 제조방법을 제공하는 것이다.It is an object of the present invention to solve the above problems and to provide a method of extracting chrysanthemum chick bone chondroitin extract powder from honeycomb, honeycomb, chrysanthemum, oak tree, A herbal composition for improving liver function, which contains Betaine, Hovenia dulcis extract powder and red ginseng, and a method for producing the same.

상기와 같은 목적을 달성하기 한 본 발명의 구기자를 포함하는 간 기능 예방 및 치료용 한방조성물은 구기자 1 ~ 30 중량부, 모과나무 1 ~ 30 중량부, 산수유 1 ~ 20 중량부, 베타인 1 ~ 20 중량부, 홍삼 1 ~ 10 중량부, 헛개나무추출분말 1 ~ 10 중량부, 벌꿀 1 ~ 30 중량부, 개다래나무열매 1 ~ 30 중량부, 맥주효모 1 ~ 20 중량부, 대추 1 ~ 20 중량부, 갈대 1 ~ 20 중량부, 녹차 1 ~ 20 중량부, 오갈피나무 1 ~ 20 중량부, 발레리안추출물분말 1 ~ 20 중량부, 닭흉부연골추출분말 1 ~ 20 중량부 및 양파 1 ~ 10 중량부를 포함하는 것을 특징으로 한다.In order to achieve the above object, the present invention provides a herbal composition for preventing and treating hepatic function, comprising 1 to 30 parts by weight of gugija, 1 to 30 parts by weight of corn, 1 to 20 parts by weight of corn oil, 1 to 10 parts by weight of red ginseng, 1 to 10 parts by weight of extract of Hovenia dulcis, 1 to 30 parts by weight of honey, 1 to 30 parts by weight of ginkgo nut, 1 to 20 parts by weight of brewer's yeast, 1 to 20 parts by weight of jujube 1 to 20 parts by weight of reed, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of oak tree, 1 to 20 parts by weight of valerian extract powder, 1 to 20 parts by weight of chest chest cartilage extract powder and 1 to 10 parts by weight of onion And the like.

또한, 본 발명은 상기 조성물에 담체, 부형제 또는 희석제 중 어느 하나를 더 포함할 수 있다.The present invention may further include any one of a carrier, an excipient, and a diluent in the composition.

또한, 본 발명은 개다래나무 1~30 중량부, 구기자 1~30 중량부, 모과나무 1~30 중량부, 오갈피나무 1~30 중량부, 갈대 1~20 중량부, 녹차 1~20 중량부, 산수유 1~20 중량부, 대추 1~20 중량부, 양파 1~10 중량부 및 홍삼 1~10 중량부의 약재를 건조시켜 분쇄기로 파쇄하여 균질하게 혼합하는 1단계;In addition, the present invention relates to a method for producing a green tea, which comprises 1 to 30 parts by weight of gentiana, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 20 parts by weight of reeds, 1 to 20 parts by weight of corn oil, 1 to 20 parts by weight of jujube, 1 to 10 parts by weight of onion, and 1 to 10 parts by weight of red ginseng are dried and crushed by a pulverizer to homogeneously mix;

상기 혼합된 건조약재 40 ~ 55 중량부와 정제수 45 ~ 60 중량부를 넣고, 고온(95~120℃)에서 장시간(4~8시간)을 증류추출기에서 추출하는 2단계;및(2) a step of extracting 40 to 55 parts by weight of the mixed dry chemical and 45 to 60 parts by weight of purified water from a distillation extractor at a high temperature (95 to 120 ° C) for a long time (4 to 8 hours)

상기 2단계의 복합 추출물 10~90 중량부를 교반기에 넣고 벌꿀 1~20 중량부, 발레리안추출물분말 1~10 중량부, 닭흉부연골추출분말 1~10 중량부, 맥주효모분말 1~10 중량부, 베타인 1~10 중량부, 헛개나무추출분말 1~20 중량부, 액상저당 1~10 중량부 및 구아검 1~10 중량부를 첨가하여 균질하게 중온(40~90℃)에서 (1000~4000rpm)속도로 혼합하는 3단계; 를 포함하는 것을 특징으로 하는 구기자를 포함하는 간 기능 개선용 한방 조성물의 제조방법을 제공한다. 10 to 90 parts by weight of the complex extract of the above two stages is added to a stirrer and 1 to 20 parts by weight of honey, 1 to 10 parts by weight of valerian extract powder, 1 to 10 parts by weight of chest chest cartilage extract powder, 1 to 10 parts by weight of beer yeast powder 1 to 10 parts by weight of Betaine, 1 to 20 parts by weight of Hovenia dulcis extract powder, 1 to 10 parts by weight of liquid phase mortar and 1 to 10 parts by weight of guar gum are homogeneously added at a temperature of from 40 to 90 ° C ) Speed; And a method for manufacturing a herbal composition for improving liver function, comprising the step of preparing the composition.

또한, 바람직하게 상기 3단계의 조성물에 담체, 부형제 또는 희석제 중 어느 하나를 혼합하는 단계를 더 포함할 수 있다. In addition, the method may further include a step of mixing any one of the carrier, excipient, and diluent with the three-step composition.

본 발명에 의하면 구기자, 개다래, 발레리안 추출물 등의 유효성분을 포함함으로써, 간기능 수치인 AST, ALT, γ-GTP에 대하여 수치를 낮추고 효과를 촉진시키는 것으로 간 기능 개선에 유용하게 이용될 수 있다.According to the present invention, by including an active ingredient such as gojiwon, mackerel, and valerian extract, it can be usefully used for improving liver function by lowering the value of AST, ALT and γ-GTP, which are liver function values, .

본 발명은 개다래를 포함하는 간 기능 개선용 한방조성물 및 그 제조방법에 관한 것으로서, 보다 상세하게는 구기자, 모과나무, 오갈피나무, 산수유, 개다래나무, 갈대, 녹차, 양파, 대추, 발레리안 추출분말, 맥주 효모, 닭흉부연골추출분말, 꿀, 베타인, 헛개나무 추출분말 및 홍삼을 포함함으로써, 간 기능 개선용 한방 조성물 및 그 제조 방법에 관한 것이다.The present invention relates to a herbal composition for improving liver function and a method for preparing the same, and more particularly, to a herbal composition for improving liver function comprising ginseng, jalapeno extract, , Brewer's yeast, chest chest cartilage extract powder, honey, betaine, hinoki extract powder and red ginseng, and a herb composition for improving liver function and a preparation method thereof.

본 발명을 실시예를 들어 설명을 하면 다음과 같다. 본 발명은 하기의 실시예에 한정되지 않으며, 본 발명이 속한 기술분야의 당업자에 의한 다양한 변형이 가능함을 이해할 것이다.Hereinafter, the present invention will be described by way of examples. It will be understood that the invention is not limited to the embodiments described below and that various modifications are possible to those skilled in the art to which the invention pertains.

이하에서는, 본 발명에 사용된 천연물들에 대하여 간략하게 설명하고자 한다.Hereinafter, the natural products used in the present invention will be briefly described.

닭흉부연골추출분말(Chicken Sternum Cartilage)은 콜라겐에 여러 구조 중 2형 타입에 해당하는 물질로 단백질, 콘드로이틴황산, 수분, 인, 회분 등으로 구성되어 있다. 콜라겐은 생체를 구성하는 중요한 단백질의 한종류로서 피부나 관절 연골에 많이 분포하고 그 외에 인대, 뼈, 혈관 등 전신에 넓게 분포하고 있다. 생체 내에서의 분포나 성질에 따라 1형,2형,3형~20형 등으로 분류되고 있다. 그중 관절에 주성분은 수분을 제외하고는 대부분이 2형 구조의 콜라겐이다. 이 성분은 연골의 윤활유 역할을 해주는 물질이며 조직 내에서 수분을 끌어당겨 결합하여 관절의 움직임을 부드럽게 되도록 도와주는 역할을 하여 골관절염 및 류마티스염의 통증을 완화시키고 연골의 퇴행을 늦추는 결과가 보고되어 있다.(Xv Jiqu et al. CHINESE JOURNAL OF PUBLIC HEALTH, 2006. 22). 또한 기성한약서인 “본초”에 황자계늑골(黃雌鷄肋骨)로서 처방한 기록이 있다.Chicken Sternum Cartilage (Chicken Sternum Cartilage) is a type of collagen-type two-type structure composed of protein, chondroitin sulfate, moisture, phosphorus and ash. Collagen is a kind of important protein that constitutes the living body. It is widely distributed in the skin and articular cartilage, and is distributed widely in the ligaments, bones, and blood vessels. It is classified into type 1, type 2, type 3 to type 20 according to the distribution and properties in vivo. Among them, the major component of joints is collagen of type 2, except for water. This ingredient acts as a lubricant for the cartilage, and it has been reported that it attracts moisture in the tissue to help soften the movement of joints, thereby alleviating the pain of osteoarthritis and rheumatism, and slowing degeneration of cartilage. (Xv Jiqu et al., CHINESE JOURNAL OF PUBLIC HEALTH, 2006. 22). In addition, there is a record of prescription of "Huangzhong" rib (黄 雌 鷄 rib bone) on "Huancho" which is an old Chinese medicine book.

길초근(Valeriana fauriei)은 광릉 쥐오줌풀(Valeriana faurieivar. dasycarpa Hara), 넓은잎 쥐오줌풀 (Valeriana officinalis L.var.latifoliaMiq.)의 뿌리 및 근경이다. 쥐오줌풀은 산 속, 강변, 냇가 등에서 자생하는 반음지성 초본류로서 특유의 향취를 가지고 있다. 마타릿과의 여러해살이풀로서, 높이는 1미터 정도이며, 잎은 마주나고 우상 복엽이다. 5~8월에 연한 붉은색 꽃이 피고 열매는 깃털 모양이다. 뿌리는 약용하고 산의 습지에서 자라는데 한국, 일본, 대만, 중국 동북부 등지에 분포한다.Valeriana fauriei is the root and rootstock of Valeriana faurieivar. Dasycarpa Hara, Valeriana officinalis L. var.latifoliaMiq. It is a semi-ominous herbaceous plant native to the mountains, riverside, and streams, and has a unique flavor. It is a perennial herbaceous plant with martitis, about 1 meter in height, with leaves facing each other and an idyllic leaf. From May to August, light red flowers bloom and the fruit is feathery. The roots are medicinal and are grown in mountain wetlands, distributed in Korea, Japan, Taiwan, and northeastern China.

구기자는 가지과의 낙엽, 활엽, 관목으로 구기자나무 열매를 구기자라 하며 우리나라 전역에 자생하고 있다. 한방에서는 잎을 구기엽, 열매를 구기자, 뿌리를 지골피라 하며 아미노산, 비타민등이 함유되어 있어 정력감퇴, 결막염, 피로회복, 현기증 등에 이용되고 있다. 예로부터 불로장생의 묘약으로 불리워져 왔으며 강장,강정, 건위에 효과가 있고 허약체질개선, 현기증 등에도 좋다. 구기자에는 비타민,루틴, 베타인, 아미노산 등이 들어 있어 강장제로서 효능이 높고, 동맥경화, 고혈압의 예방 등에 효과가 있다. Gugija is a leaf, leaf, and shrub of branches, and is known as a goji tree. It grows throughout the country. In one room, it is called leaf, leaf, fruit, and root. It contains amino acids and vitamins. It is used for dementia, conjunctivitis, fatigue and dizziness. It has been called as a potion of a non-living person since ancient times, and it has effects on tonic, gangjeong, and dryness. It is also good for improvement of fragility and dizziness. Gugija contains vitamins, rutin, betaine, and amino acids, so it is highly effective as a tonic, and is effective in preventing arteriosclerosis and hypertension.

발레리안 추출물((Valeriana offcinails L.)학명을 가지며 뿌리부분을 에탄올에 추출하여 덱스트린과 혼합 후 건조한 분말이다. 중추 신경계 안정과 뇌파 중 안정감을 느끼게 하는(α-wave)파의 발생을 증가시켜 집중력을 강화하며 긴장을 완화하게 하여 스트레스 감소에 도움을 주도록 합니다.(Valeriana offcinails L.) It is a dry powder after extracting roots part with ethanol and mixing with dextrin. It is a powder that has a strong central nervous system stability and a feeling of stability in brain waves (α-wave) To help reduce stress and reduce stress.

베타인은 식물과 동물의 체내에 널리 분포하며, 생체 내에서 콜린의 비가역적인 산화과정을 통해 합성된다. 베타인은 유황전달경로에서 호모시스테인에 메틸기를 전달하여 메티오닌으로 전환시키는 역할을 한다. 상기 베타인은 베타인 무수물, 베타인 수화물, 또는 염산염이나 그 외 물에 용해시켰을 때 베타인을 유리할 수 있는 다른 종류의 약학적으로 허용 가능한 그의 염을 포함한다. 상기 베타인은 공지된 방법에 의해 천연물로부터 추출된 것이나 합성된 것을 적의 사용할 수 있으며, 그 제조 방법이나 기원은 한정되지 않는다.Betaine is widely distributed in plants and animals and is synthesized in vivo through the irreversible oxidation of choline. Betaine plays a role in transferring methyl groups to homocysteine and converting it into methionine in the sulfur transport pathway. The betaine includes betaine anhydride, betaine hydrate, or any other pharmaceutically acceptable salt thereof that may be beneficial to betaine when dissolved in hydrochloride or other water. The betaine may be any of those extracted or synthesized from natural products by known methods, and the production method and origin of the betaine are not limited.

개다래(Actinidia polygama)는 다래나무(미후리)과 (Actinidiaceae)에 속한 낙엽 덩굴성 식물인 개다래 나무의 과실로, 이에 대한 성분으로는 자당, 점액질, 전분, 단백질, 탄닌, 유기산, 비타민 C, 비타민 A, 비타민 P 등이 함유되어 있는 것으로 알려져 있으며, 지금까지 알려진 효과로는 지갈(止渴), 해번열(解煩熱)과 비뇨기 결석(泌尿器結石) 치료가 있다(정보섭 및 신민교, 향약대사전, 영림사, p386-387, 1998).Actinidia polygama is a fruit of Gentiana, a deciduous vine plant belonging to Actinidiaceae, which is composed of sucrose, mucilage, starch, protein, tannin, organic acid, vitamin C, vitamins A, and vitamin P, and the known effects include cicada, juvenile fever and urological stone treatment (ubiquitous stone, ubiquitous stone, Young Lim, p386-387, 1998).

맥주효모는 맥주를 발효시키는 역할을 하는 것으로서, 맥주를 만드는 과정에서 맥주를 분리시키면 위에는 맥주가 뜨고 아래에는 맥주효모가 가라앉게 되는데, 이것을 건져 150~200℃에 순간 건조하여 만든 것을 건조 맥주효모(Brewey's Yeast)라 한다. 맥주 효모가 병의 치료나 건강증진 목적에 오래전부터 사용되어 왔으나 최근 학자들에 의해서 뇌세포를 활성화해주는 고단백질 식품으로 주목을 받고 있다.Brewer's yeast is responsible for fermenting beer. When beer is separated from the beer making process, the beer is opened on the top and the brewer's yeast is submerged on the bottom. Brewey's Yeast). Brewer's yeast has been used for a long time for the purpose of medical treatment and health promotion, but it is getting attention as a high-protein food which activates brain cells by scholars recently.

모과는 주로 차나 술을 만들어 먹는 것으로, 소화 촉진, 보혈과 조혈작용, 항이뇨 작용 및 위장과 사지의 근육을 풀어주고, 힘을 갖게 하는 등 다양한 약효를 가지고 있는 것으로 알려져 있다. 그러나 상기 모과는 피로회복이나 스트레스를 억제하는 활성이 있는지에 대해서는 알려진 바가 전혀 없다.It is known to have a variety of medicinal effects such as digestion promotion, blood and hematopoiesis, antidiuretic action, muscles of the stomach and limbs, and strength. However, it is not known whether the quince has activity to restrain fatigue or stress.

노근은 우리나라에서 많이 자생하는 갈대의 뿌리를 말한다. 상기 노근은 약리작용으로 이뇨작용,해열작용, 간 보호 작용, 조혈기능 강화작용 등이 있는 것으로 알려져 있을 뿐 구체적인 약리활성에 대해서는 알려진 바가 없으며 피로회복이나 스트레스를 억제하는 활성이 있는지에 대해서는 알려진 바가 전혀 없다.Nogeun refers to the root of reed which grows wild in Korea. There is no known specific pharmacological activity, nor is there any known activity for restoring fatigue or stress at all. It is known that there is no pharmacological activity such as diuretic action, antipyretic action, liver protective action, none.

오가피는 인삼과 같은 두릅나무과에 속하는 낙엽활엽관목으로, 오갈피라고도 하며 우리나라와 중국, 러시아에서도 생산된다. 동의보감이나 본초강목에 의하면 오가피 뿌리, 줄기 및 가지의 껍질 등을 장기복용하면 몸을 가볍게 한다 하여 오래 전부터 사용해왔으며, '제2의 인삼'으로 불린다.Ogapi is a deciduous broad-leaved shrub belonging to Araliaceae such as ginseng. It is also called Ogalli and is also produced in Korea, China and Russia. According to Dong-bo-bo-gang or Bon-gae Gangmok, it has been used for a long time and it is called 'second ginseng' by long-lasting taking the roots, stem and branches of the gangs.

녹차는 민간에서 건강기호 음료로서 널리 음용되어 왔으며 현재에 와서는 국내외 많은 학자들의 연구에 의해 고혈압 및 동맥경화 예방효과, 항암효과, 노화 억제효과, 당뇨병 억제효과, 해독작용, 피부미용 및 피로 회복 효과, 충치예방 효과가 있는 것으로 알려졌다. 녹차 생엽의 구성성분을 보면 70∼80 중량부가 수분이고, 나머지가 고형물로서 폴리페놀, 카페인, 아미노산, 탄수화물, 색소성분(엽록소, 카로티노이드, 플라보놀 유도체, 안토시안)외에 유기산이나 향기성분, 효소, 비타민, 무기성분 등으로 구성되어 있다.Green tea has been extensively used as a health drink in the private sector and has been widely used by many scholars at home and abroad for the prevention of hypertension and arteriosclerosis, anticancer, antioxidative, diabetic, detoxifying, It is known that it has the effect of preventing cavities. The green tea leaves have 70 to 80 parts by weight of water and the remainder are solids such as polyphenols, caffeine, amino acids, carbohydrates, pigment components (chlorophyll, carotenoids, flavonol derivatives and anthocyanins), organic acids, , And inorganic components.

갈근은 칡뿌리의 껍질로서 냄새는 없고 약성은 달며 맵고 평하다. 갈근은 땀을 내며, 열을 내려 고열·두통을 치료하고 갈증을 멎게 한다. 소화불량, 두통, 빈혈, 이질, 복통, 술독, 감기, 구토와 부인들의 하혈에 쓰이고 소화를 돕는다. 생뿌리를 짓찧어 즙을 내어 마시기도 한다. 칡의 열매는 갈곡이라 하며 설사에 효과가 있고 칡꽃인 갈화는 독특한 단맛이 있어 술독을 풀어 주고 장을 튼튼하게 한다. It is a bark of roots and has no smell. Changgeun sweat, fever, fever, healing headache and stop the thirst. It is used for digestion, headache, anemia, dysentery, abdominal pain, dryness, cold, vomiting and bleeding of wife. It blooms raw roots and sucks and drinks. The fruit of the 칡 is called the gag, and it is effective in the diarrhea. The 칡 flower which is a 칡 flower has a unique sweetness, and it releases the digestion and strengthens the intestines.

쥐오줌풀(길초근)은 동속근연식물로 좀쥐오줌풀, 넓은잎 쥐오줌풀, 광릉 쥐오줌풀 등이 있으며 모두 약재로 사용된다. 이 약은 특이한 냄새가 있고 맛은 맵고 쓰며 성질은 따듯하다. 길초근은 정신불안으로 인한 가슴 뜀, 불면, 쉽게 놀라는 증상, 신경쇠약, 심근염, 산후 심장병, 심박쇠약, 고산병, 생리불순, 위경련, 관절점, 타박상 등에 사용한다. 약리작용으로 진정작용, 진경작용, 혈압강하, 그람양성균 억제작용, 이뇨작용 등이 보고되었다.Pseudoptera (Porphyra vulgaris) is a relative plant belonging to the same genus. This medicine has a peculiar smell, and the taste is spicy and the quality is warm. It is used for chest leaks caused by mental anxiety, insomnia, easily frightening symptoms, nervous breakdown, myocarditis, postpartum heart disease, heart failure, altitude sickness, menstrual irregularity, stomach cramps, joint points, bruises. Pharmacological actions such as sedation, antipyretic action, hypotension, Gram-positive bacterial inhibitory action, and diuretic action have been reported.

산수유는 신장 요로계통과 성인병, 부인병 등에 효능이 있고, 특히 성기능 회복에 도움이 되고 땀을 멎게 하며 열을 내리고 음기를 보충해 준다. 소변을 너무 자주 보는 빈뇨 현상에도 효과적이다.Corn oil is effective for adults and women who pass through the urinary tract of the kidney, especially helps to restore sexual function, stop sweating, heat down and replenish the tongue. It is also effective in frequent urination to urinate too often.

벌꿀(Honey)은 피로회복, 빈혈의 예방 및 치료, 당뇨병의 당원공급, 간장병의 예방 및 치료, 숙취해소, 천연 종합영양제, 미용효과, 유아의 발육촉진, 살균효과 등의 효능을 갖는 것으로 알려져 있다.꿀의 주성분인 과당(fructose)은 천연 감미료로서 식품의 원료로 쓰이고 있다.Honey has been known to have the effects of restoring fatigue, preventing and treating anemia, supplying diabetic patients, prevention and treatment of liver diseases, relieving hangover, natural nutritional supplement, beauty effect, infant growth promotion and sterilization effect Fructose, the main component of honey, is used as a raw material for food as a natural sweetener.

인삼은 사포닌 글리코시드(사포닌배당체)인 긴세노사이드류, 스테로이드, 비타민 B군, 콜린 등이 함유되어 있다. 강장, 강심, 건위, 보정, 진정, 자양 등의 약으로 사용되고 위장 등의 기능 쇠약에 의한 물질대사 기능의 저하에 부활제로 사용되며, 병약자의 위부정체감, 소화불량, 구토, 흉통, 이완성 설사, 식욕부진 등에도 사용된다.Ginseng contains saponin glycoside (saponin glycoside), long senoside, steroid, vitamin B group, choline and the like. It can be used as a revitalizing agent for depression of metabolic function by weakness of function such as stomach and the like and it is used as a medicine for depression, dyspepsia, vomiting, chest pain, diarrhea, appetite, It is also used for sluggishness.

대추(Zizyphus jujuba Mill var. inermis Rehder)는 갈매나무과에 속하는 활엽교목으로, 약용과 식용을 겸하여 사용된다.높이가 10m에 달하며 가지는 미끄럽고 가시가 있다. 개화기는 6월이며 결실기는 9-10월이다. 마릉 부근 및 밭뚝 등에 나며 전국에 분포되어 있으며 재배도 가능하다.Jujube (Zizyphus jujuba Mill var. Inermis Rehder) is a broad-leaved arboreous tree belonging to the family Seagaceae. It is used for medicinal and edible purposes. It has a height of 10m and its branches are slippery and prickly. The flowering period is June, and the fertilization period is from September to October. It is distributed in the vicinity of the marlon and in the field and it is distributed throughout the country and it is possible to cultivate.

양파는 폐경기 나이에 접어든 여성에서 매우 유용하며 양파는 뼈 손실을 억제하는 데 도움이 되기 때문에 골다공증의 발생 가능성을 줄일 수 있다. 퀘르세틴 성분을 다량 함유하고 있는 양파는 혈액 속의 좋지 않은 콜레스테롤 수치를 낮춰주는 역할을 하며 지방성분을 분해해주는 효과가 있어 혈액의 원활한 순환을 도와 동맥경화와 고혈압, 고지혈증 등 다양한 혈관 질환을 효과적으로 예방해준다고 한다. Onions are very useful in women who are at the age of menopause, and onions can help reduce bone loss and reduce the likelihood of osteoporosis. The onion, which contains a lot of quercetin, lowers the bad cholesterol level in the blood and has the effect of decomposing the fat component, which helps the circulation of the blood, effectively preventing arteriosclerosis and various vascular diseases such as hypertension and hyperlipemia .

본 발명의 목적을 달성하기 위하여 개다래나무 열매, 구기자, 모과나무, 오갈피나무, 산수유, 갈대, 녹차, 양파, 대추, 발레리안추출분말, 맥주효모, 닭흉부연골추출분말, 꿀, 베타인, 헛개나무추출분말, 홍삼을 선별하고, 이들을 혼합하여 한방 조성물을 제조한 후, 이를 정량 및 정성 분석시험를 측정하고 인체적용 간이시험으로 간기능 개선 시험을 수행하여 관찰한 결과 본 발명에 따른 한방조성물이 간기능 장애 증상을 완화시킬 수 있음을 확인함으로써 달성되었다.In order to accomplish the object of the present invention, there is provided a method for producing a chrysanthemum extract, comprising the steps of: extracting ginkgo nut, gugija, quince tree, oak tree, marine oil, reed, green tea, onion, jujube, valerian extract powder, brewer's yeast, Extracts of red ginseng, wood extract powder and red ginseng were mixed to prepare a herbal composition. Then, a quantitative and qualitative analysis test was conducted, and a hepatic function improvement test was conducted by a human body simple test. As a result, It was achieved by confirming that the symptoms of dysfunction can be alleviated.

본 발명의 조성물은 약학적 조성물의 제조에 통상적으로 사용하는 적절한 담체, 부형제 및 희석제를 더 포함할 수 있다.The compositions of the present invention may further comprise suitable carriers, excipients and diluents conventionally used in the manufacture of pharmaceutical compositions.

본 발명은 구기자 1 ~ 30 중량부, 모과나무 1 ~ 30 중량부, 산수유 1 ~ 20 중량부, 베타인 1 ~ 20 중량부, 홍삼 1 ~ 10 중량부, 헛개나무추출분말 1 ~ 10 중량부, 벌꿀 1 ~ 30 중량부, 개다래나무열매 1 ~ 30 중량부, 맥주효모 1 ~ 20 중량부, 대추 1 ~ 20 중량부, 갈대 1 ~ 20 중량부, 녹차 1 ~ 20 중량부, 오갈피나무 1 ~ 20 중량부, 발레리안추출물분말 1 ~ 20 중량부, 닭흉부연골추출분말 1 ~ 20 중량부 및 양파 1 ~ 10 중량부로 이루어진 한방 조성물을 유효성분으로 함유하는 간기능 개선용 약제학적 조성물, 식품 조성물 및 건강기능식품 조성물을 제공한다.The present invention relates to a method for producing a starch powder comprising 1 to 30 parts by weight of gugija, 1 to 30 parts by weight of corn oil, 1 to 20 parts by weight of corn oil, 1 to 20 parts by weight of betaine, 1 to 10 parts by weight of red ginseng, 1 to 30 parts by weight of honey, 1 to 30 parts by weight of gentian fruit, 1 to 20 parts by weight of brewer's yeast, 1 to 20 parts by weight of jujube, 1 to 20 parts by weight of reed, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of valerian extract powder, 1 to 20 parts by weight of chest chest cartilage extract powder and 1 to 10 parts by weight of onion as an active ingredient, a pharmaceutical composition for improving liver function, a food composition, Health functional food composition.

이하, 본 발명의 바람직한 실시예를 제시한다. 다만, 하기 실시예는 본 발명의 이해를 돕기 위하여 제시되는 한 예일 뿐 본 발명이 하기 실시예에 한정되는 것은 아니다.Hereinafter, preferred embodiments of the present invention will be described. However, the following examples are given to aid understanding of the present invention, and the present invention is not limited to the following examples.

<< 실시예Example 1 ~ 5: 본 발명에 따른 간 기능 개선용 한방 조성물의 제조> 1 to 5: Preparation of the herbal composition for improving liver function according to the present invention>

성 분ingredient 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 개다래나무Jindiae 22 44 1010 1515 1515 구기자Gugija 33 2020 55 1One 2020 모과나무Quince tree 33 55 55 1One 55 오갈피나무Apricot tree 33 55 55 1One 55 갈대Reed 1010 55 55 55 55 녹차green tea 1010 55 22 55 1010 산수유Corn oil 1010 55 22 55 55 대추Jujube 1010 55 22 55 55 양파onion 1One 1One 22 1One 22 홍삼Red ginseng 1One 1One 00 1One 1One 정제수Purified water To. 100To. 100 To. 100To. 100 To. 100To. 100 To. 100To. 100 To. 100To. 100

표 1. 한방 조성물의 성분함량표 (단위:중량부)Table 1. Ingredient Content Table of Oriental Compositions (unit: parts by weight)

본 발명은 상기 표 1에 따라, 개다래나무 1~30 중량부, 구기자 1~30 중량부, 모과나무 1~30 중량부, 오갈피나무 1~30 중량부, 갈대 1~20 중량부, 녹차 1~20 중량부, 산수유 1~20 중량부, 대추 1~20 중량부, 양파 1~10 중량부 및 홍삼 1~10 중량부의 약재를 건조시켜 분쇄기로 파쇄하여 균질하게 혼합한 후, 상기 혼합된 건조약재 40 ~ 55 중량부와 정제수 45 ~ 60 중량부를 넣고, 고온(95~120℃)에서 장시간(4~8시간)을 증류추출기에서 추출한다. According to the present invention, according to the above Table 1, 1 to 30 parts by weight of gentiana, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 20 parts by weight of reed, 20 to 50 parts by weight of soybean oil, 1 to 20 parts by weight of soybean oil, 1 to 20 parts by weight of jujube, 1 to 20 parts by weight of jujube, 1 to 10 parts by weight of onion, and 1 to 10 parts by weight of red ginseng are dried, crushed by a pulverizer, homogeneously mixed, 40 to 55 parts by weight of water and 45 to 60 parts by weight of purified water are added and the mixture is extracted at a high temperature (95 to 120 ° C) for a long time (4 to 8 hours) in a distillation extractor.

농축 추출물의 경우, 한약재 특성상 100℃ 이상 온도를 가해주어야 추출성분 및 증류 유효성분들이 분리가 되기 때문에 고온 적정 온도가 바람직하며, 단시간 4시간 이내 추출은 농도가 너무 묽고 유효성분들이 잘 추출되지 않고 8시간 이상의 장시간 추출시, 증류양이 너무 많아져 추출액이 줄어들고 심한 경우 추출물이 타는 경우도 발생한다. In the case of the concentrated extract, it is preferable to apply a temperature of 100 ° C or higher in order to separate the extraction component and the distillation effective components. Therefore, the high temperature optimum temperature is preferable, and the extraction within 4 hours within a short period of time is too dilute, When extracting for a long time longer than the time, the amount of distillation becomes too much and the extract is reduced.

성 분ingredient 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 발레리안 추출분말Valerian extract powder 00 44 33 1515 1515 닭흉부연골추출분말Chest chest cartilage extract powder 33 2020 1One 1One 2020 맥주효모분말Beer yeast powder 55 55 1One 1One 55 베타인Betaine 1One 55 55 1One 55 헛개나무추출분말Houttree tree extract powder 1010 55 00 55 55 액상저당Liquid mortgage 1010 55 22 55 1010 구아검Guar gum 1010 55 22 55 55 honey 1010 55 33 55 55 상기 표1 추출물Table 1 Extract To. 100To. 100 To. 100To. 100 To. 100To. 100 To. 100To. 100 To. 100To. 100

표 2. 한방 조성물의 성분함량표 (Table 2. Ingredient Content Table of Oriental Compositions ( 단위:중량부Unit: parts by weight ))

다음으로, 상기 복합 추출물(10~90 중량부)을 교반기에 넣고 벌꿀 1~20 중량부, 발레리안추출물분말 1~10 중량부, 닭흉부연골추출분말 1~10 중량부, 맥주효모분말 1~10 중량부, 베타인 1~10 중량부, 헛개나무추출분말 1~20 중량부, 액상저당 1~10 중량부, 구아검 1~10 중량부을 같이 첨가하여 균질하게 중온(40~90℃)에서 (1000~4000rpm)속도로 혼합하였다. Next, the complex extract (10-90 parts by weight) was added to a stirrer, and 1 to 20 parts by weight of honey, 1 to 10 parts by weight of valerian extract powder, 1 to 10 parts by weight of chest chest cartilage extract powder, 1 to 10 parts by weight of betaine, 1 to 20 parts by weight of Houttuynia cordata extract, 1 to 10 parts by weight of a liquid phase mortar and 1 to 10 parts by weight of guar gum are added thereto and homogeneously mixed at a middle temperature (40 to 90 ° C) (1000 to 4000 rpm).

상기 표 1의 추출물과 상기 표 2의 성분들을 혼합기 교반속도가 너무 느리면 점증제 역할을 하는 저당이나 구아검 원료들이 혼합되지 않고 비중에 의하여 바닥면에 가라앉는다. When the mixing speed of the mixer is too slow, the extract of Table 1 and the components of Table 2 are not mixed with the mortar or guar gum raw materials which act as an incrementer and sink to the bottom due to specific gravity.

<실험예 1: 상기 실시예 3의 간기능 개선효과 실험><Experimental Example 1: Experimental Effect of Liver Function Improvement in Example 3>

간기능 개선과 관련하여 가장 흔히 하는 검사는 혈액 내 생화학적 수치의 변동을 보는 검사이다. 간에는 효소 함량이 많을 뿐만 아니라 해부학적으로도 효소의 혈중 유출이 용이하기 때문에 혈청 AST, 특히 ALT는 간 장애의 예민한 검사라 할 수 있다. 정상 간세포의 상청 분획에서는 AST < ALT이다. 게다가 AST는 혈중 반감기가 더 짧으므로 간 장애에서는 타 장기 질환과 달리 혈청 효소는 AST < ALT로 된다. The most common test for liver function improvement is a test for changes in blood biochemical values. Serum AST, especially ALT, is a sensitive test for hepatic disorders because it has high enzyme content in the liver as well as easy anatomical leakage of the enzyme into the blood. In the supernatant fraction of normal hepatocytes, AST <ALT. In addition, AST has a shorter half-life of blood, so the enzyme of the serum becomes AST <ALT, unlike other organ diseases in liver failure.

그러나 간경변 또는 간세포암에서는 혈류장애로 병적 세포 내의 효소활성은 AST > ALT로 그 결과 혈청 효소활성도 AST > ALT인 경우가 많다. 담즙 울체성 병변에서는 AST, ALT 증가와 비교하여 γ-GT 및 ALP 활성증가가 현저하다. AST, ALT 활성이 기준범위는 측정방법에 따라 약간 차이를 보이는데, AST 8~32 IU/L, ALT 4~30 IU/L을 기준범위로 이용한다. AST, ALT 활성치에 영향을 미치는 인자로 성별 및 연령에 따른 차이는 거의 없고, 임신에 따른 차이도 거의 없다. 그러나, 연령은 30세 이하와 30세 이상에서는 후자가 유의하게 높다는 보고도 있다. 여성에 비하여 남성이 약간 높은 경향을 보인다고 하지만 유의한 차이는 없다. 운동부하에서는 약간 증가한다.[건강기능식품 시험법가이드 참조, 2004]However, in liver cirrhosis or hepatocellular carcinoma, the enzymatic activity in pathologic cells due to blood flow disorder is AST> ALT. As a result, the serum enzyme activity is often AST> ALT. In cholestatic lesions, the increase of γ-GT and ALP activity is remarkable compared to the increase of AST and ALT. AST and ALT activity The reference range is slightly different depending on the measurement method. AST 8 ~ 32 IU / L and ALT 4 ~ 30 IU / L are used as the reference range. AST, and ALT activity, there are few differences according to gender and age, and there is little difference according to pregnancy. However, there is also a report that the latter is significantly higher in the age group below 30 and above 30. Men tend to have a slightly higher tendency than women, but there is no significant difference. [Reference to the Health Functional Food Test Guide, 2004]

혈청효소시험 간 기능 개선효과 시험을 위한 대상자는 한의사가 문진 및 설문하여 전신무력하고 간 부위 동통 및 식욕 부진 및 구통 증상이 있는 환자들을 대상으로 5명을 관찰하였다. 시험은 30일 복용을 잠자기 2시간 전 저녁시간에 하루 한 번 20 ml씩 복용하도록 하였다. 간기능 개선효과는 최종 대상자 선정시 검사한 간기능 수치(0일)와 시료 복용을 종료 30일에 각각 공복시 채혈해서 얻은 간기능 수치를 비교하였다. 간기능 지표 분석은 전혈 3ml을 2,500rpm에서 10분간 원심분리하여 혈청을 분리한 후 생화학 자동분석기(Hitachi 7600-110, 7170 automatic analyzer)를 이용하여 AST(Aspartate aminotransferase), ALT(Alanine aminotransferase), γ-GTP(γ-glutamyl transpeptidase)를 측정하였다.Serum enzyme test was performed to examine the effect of the liver function test. Five patients were examined by a Korean oriental medical practitioner who had systemic disability, liver pain, anorexia, and whitish symptoms. For the test, 30-day doses were taken 20 ml once a day in the evening two hours before sleep. The liver function improvement effect was compared with the liver function values obtained at the time of selecting the final subject and the liver function values obtained by fasting blood collection at the 30th day after the end of the sample intake. Hepatic function index analysis was performed by centrifuging 3 ml of whole blood at 2,500 rpm for 10 minutes, separating the serum, and then using AST (Aspartate aminotransferase), ALT (Alanine aminotransferase), γ -GTP (? -Glutamyl transpeptidase) was measured.

투여 전과 후의 분석은 paired t test를 실시하였다. 그리고, 하기 표 3에 도시된 바와 같이, 상기 조성물 군에서 간수치(AST, ALT, γ-GTP)의 감소효과가 나타났으며, 통계적으로 유의적(p<0.05)으로 큰 감소 효과를 나타내었으며, γ -GTP에서 효과가 큰 경향성을 보였다.Before and after the administration, paired t test was performed. As shown in the following Table 3, the composition of the present invention showed a significant decrease in the hepatic index (AST, ALT, γ-GTP) and statistically significant (p <0.05) γ-GTP.

실시예 3Example 3 시시험험 전전 (0 일일)Shi Shih-zhuang (0 day) 시시험험 후후 ( 30 일일)After the test (30 days) ALTALT 57.35±25.6857.35 ± 25.68 34.62±21.54 34.62 + - 21.54 ASTAST 53.25±61.2153.25 + - 61.21 37.59±42.66 37.59 + - 42.66 γ -GTPgamma -GTP 89.17±41.6589.17 + - 41.65 40.81±12.3740.81 + - 12.37

이와 같이, 본 발명에 의하면 상기 한약재 등의 유효성분을 포함함으로써, 간기능 수치인 AST, ALT, γ-GTP에 대하여 수치를 낮추고 효과를 촉진시키는 것으로 간 기능의 예방, 치료 및 개선에 유용하게 이용될 수 있다.As described above, according to the present invention, by containing effective ingredients such as herbal medicines, it is possible to reduce the levels of AST, ALT, and γ-GTP, which are liver function values, .

상기에 제시된 실시예는 예시적인 것으로 이 분야에서 통상의 지식을 가지는 자는 본 고안의 기술적 사상을 벗어나지 않는 범위에서 제시된 실시예에 대한 다양한 변형 및 수정 고안을 만들 수 있을 것이다. 이러한 변형 및 수정 고안에 의하여 본 고안의 범위는 제한되지 않는다.The above-described embodiments are illustrative and those skilled in the art will be able to make various modifications and alterations to the disclosed embodiments without departing from the technical idea of the present invention. The scope of this invention is not limited by these variations and modifications.

Claims (4)

구기자 1 ~ 30 중량부, 모과나무 1 ~ 30 중량부, 산수유 1 ~ 20 중량부, 베타인 1 ~ 20 중량부, 벌꿀 1 ~ 30 중량부, 개다래나무열매 1 ~ 30 중량부, 맥주효모 1 ~ 20 중량부, 대추 1 ~ 20 중량부, 갈대 1 ~ 20 중량부, 녹차 1 ~ 20 중량부, 오갈피나무 1 ~ 20 중량부, 발레리안추출물분말 1 ~ 20 중량부, 닭흉부연골추출분말 1 ~ 20 중량부 및 양파 1 ~ 10 중량부를 포함하는 것을 특징으로 하는 구기자를 포함하는 간 기능 개선용 한방조성물.1 to 30 parts by weight of corn oil, 1 to 30 parts by weight of corn oil, 1 to 20 parts by weight of corn oil, 1 to 20 parts by weight of betaine, 1 to 30 parts by weight of honey, 1 to 30 parts by weight of ganoderma, 1 to 20 parts by weight of jujubes, 1 to 20 parts by weight of jujubes, 1 to 20 parts by weight of reeds, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of oak tree, 1 to 20 parts by weight of valerian extract powder, And 1 to 10 parts by weight of an onion. &Lt; Desc / Clms Page number 24 &gt; 제1항에 있어서,
담체, 부형제 또는 희석제 중 어느 하나를 더 포함하는 것을 특징으로 하는 구기자를 포함하는 간 기능 개선용 한방조성물.
The method according to claim 1,
The composition of claim 1, further comprising a carrier, an excipient or a diluent.
개다래나무 1~30 중량부, 구기자 1~30 중량부, 모과나무 1~30 중량부, 오갈피나무 1~30 중량부, 갈대 1~20 중량부, 녹차 1~20 중량부, 산수유 1~20 중량부, 대추 1~20 중량부 및 양파 1~10 중량부의 약재를 건조시켜 분쇄기로 파쇄하여 균질하게 혼합하는 1단계;
상기 혼합된 건조약재 40 ~ 55 중량부와 정제수 45 ~ 60 중량부를 넣고, 고온(95~120℃)에서 장시간(4~8시간)을 증류추출기에서 추출하는 2단계;및
상기 2단계의 복합 추출물 10~90 중량부를 교반기에 넣고 벌꿀 1~20 중량부, 발레리안추출물분말 1~10 중량부, 닭흉부연골추출분말 1~10 중량부, 맥주효모분말 1~10 중량부, 베타인 1~10 중량부, 액상저당 1~10 중량부 및 구아검 1~10 중량부를 첨가하여 균질하게 중온(40~90℃)에서 (1000~4000rpm)속도로 혼합하는 3단계;
를 포함하는 것을 특징으로 하는 구기자를 포함하는 간 기능 개선용 한방 조성물의 제조방법.
1 to 20 parts by weight of green tea, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of corn oil, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 20 parts by weight of jujube, and 1 to 10 parts by weight of onion are dried and crushed by a pulverizer to homogeneously mix;
(2) a step of extracting 40 to 55 parts by weight of the mixed dry chemical and 45 to 60 parts by weight of purified water from a distillation extractor at a high temperature (95 to 120 ° C) for a long time (4 to 8 hours)
10 to 90 parts by weight of the complex extract of the above two stages is added to a stirrer and 1 to 20 parts by weight of honey, 1 to 10 parts by weight of valerian extract powder, 1 to 10 parts by weight of chest chest cartilage extract powder, 1 to 10 parts by weight of beer yeast powder 1 to 10 parts by weight of betaine, 1 to 10 parts by weight of liquid phase mortar and 1 to 10 parts by weight of guar gum, and mixing the mixture homogeneously at a middle temperature (40 to 90 ° C) (1000 to 4000 rpm).
Wherein the method comprises the step of administering the composition to a subject in need thereof.
제3항에 있어서,
3단계의 조성물에 담체, 부형제 또는 희석제 중 어느 하나를 혼합하는 단계를 더 포함하는 것을 특징으로 하는 구기자를 포함하는 간 기능 개선용 한방조성물의 제조방법.
The method of claim 3,
A method for preparing a herbal composition for improving liver function, comprising the step of mixing the composition of step (3) with a carrier, an excipient or a diluent.
KR1020160064766A 2016-05-26 2016-05-26 Medicinal-Herb Composition Comprising Chinese matrimony vine for Treatmenting and Protecting the Insomniac and the Method of Making the Same KR101795261B1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111011854A (en) * 2018-10-09 2020-04-17 杏辉天力(杭州)药业有限公司 Wolfberry extract and preparation method and application thereof
KR102281794B1 (en) * 2020-01-30 2021-07-26 계명대학교 산학협력단 Composition for protecting hepatic damage on heavy metal comprising extracts from Dendropanax morbifera

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111011854A (en) * 2018-10-09 2020-04-17 杏辉天力(杭州)药业有限公司 Wolfberry extract and preparation method and application thereof
KR102281794B1 (en) * 2020-01-30 2021-07-26 계명대학교 산학협력단 Composition for protecting hepatic damage on heavy metal comprising extracts from Dendropanax morbifera

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