KR101795261B1 - Medicinal-Herb Composition Comprising Chinese matrimony vine for Treatmenting and Protecting the Insomniac and the Method of Making the Same - Google Patents

Abstract

The present invention relates to a method for producing a chrysanthemum extract, which comprises extracting a chrysanthemum, a quince tree, an apteryx, a marine oil, a jade tree, a reed, a green tea, an onion, a jujube, a valerian extract powder, a brewer's yeast, a chest chest cartilage extract powder, The present invention relates to a herbal composition useful for improving liver function by containing an active ingredient and a method for producing the same.
The herbal composition for improving liver function according to the present invention comprises 1 to 30 parts by weight of corn germ, 1 to 30 parts by weight of corn, 1 to 20 parts by weight of corn oil, 1 to 20 parts by weight of betaine, 1 to 10 parts by weight of red ginseng 1 to 10 parts by weight of extracts of Hovenia dulcis, 1 to 30 parts by weight of honey, 1 to 30 parts by weight of gentian fruit, 1 to 20 parts by weight of brewer's yeast, 1 to 20 parts by weight of jujube, 1 to 20 parts by weight of reeds, 1 to 20 parts by weight of an oak tree, 1 to 20 parts by weight of an oak tree, 1 to 20 parts by weight of a valerian extract powder, 1 to 20 parts by weight of a chest chest cartilage extract powder and 1 to 10 parts by weight of an onion.
The present invention also provides a method for producing a herbal composition-containing herbal composition for improving liver function.
According to the present invention, it can be effectively used for improving liver function by containing active ingredients such as goji, quince, and valerian extract.

Description

TECHNICAL FIELD The present invention relates to a herbal composition for improving liver function and a method for preparing the same, and a medicinal herb composition and method for preparing the same,

The present invention relates to a herbal composition for improving liver function and a method of preparing the same, and more particularly, to a herbal composition for improving liver function including gugija, and more particularly to a herbal composition for improving liver function including gugija, quince tree, oak tree, , Brewer's yeast, chest chest cartilage extract powder, honey, betaine, hinoki extract powder and red ginseng effective ingredient for improving liver function and a method for preparing the same.

The term "hepatopathic blood", a Chinese medicine term, refers to a state in which blood is sufficiently stored in the liver, and in Oriental medicine, sleep is possible in this state. As our society has rapidly changed into a modern society, our lifestyles have changed, and our urban life patterns are fast and busy, lacking 24 hours. On the other hand, the liver has time to recharge when it is fasting or sleeping, and these modern habits also affect the activation of advanced secondary functions in addition to detoxification. Hormone metabolism, etc., are also more active when the digestive system is free of food, physical activity is minimized, or sleep is full. Moreover, workers who suffer from heavy work and stress, frequent night shifts, and frequent groups are more likely to be exposed to physical imbalance due to drinking and night work.

The liver plays an important role in detoxifying all foods that are absorbed by the body, storing nutrients in the liver, and being secreted like bile to regulate blood flow. If the liver function is low, GOT, GPT, GTP (Gamma jittii) will rise, and waste products and toxins will not be discharged well. Various complications (hepatic coma, ascites, esophageal varices, thrombocytopenia) Abdominal bloating (etc.) Headache, gum bleeding occurs. The liver is called the organ of silence, so self-diagnosis is not easy.

On the market, medicines, beverages, and health functional foods with liver function are on the market, but they focus on enzymes that directly function in relation to drinking and liver function. Sleep and liver function are closely linked, and inflammation is a biological reaction caused by such an imbalance. Detoxification and new cell formation to enhance the quality of sleep and to activate the advanced functions of the liver, thereby providing a composition that has both sleeping function and liver function at the same time, and can further inhibit the inflammatory response The need for natural medicines using herbal medicines is emerging.

The inventors of the present invention have found that the extract of chrysanthemum chrysanthemum extract, which is useful for improving liver function, inflammation, and allergy, and which is useful for treatment, such as Gugija, Quercus mongolica, Ogakkii, Maruchis japonica, Reed, Green tea, Onion, Jujube, Valerian extract powder, The present inventors completed the present invention by confirming that the composition containing honey, betaine, hinoki extract powder and red ginseng can be used for improving and treating liver function.

It is an object of the present invention to provide a pharmaceutical composition for improving liver function, a food composition and a health functional food composition containing the herbal composition.

Therefore, the present study was conducted to evaluate the possibility of development as a liver function improving efficacy therapeutic drug by observing the liver function improving effect of a herbal composition which is expected to have an effect on liver function with a cell line.

Registration No. 10-1292931: A composition for preventing or treating non-alcoholic fatty liver disease comprising an acne extract as an active ingredient

It is an object of the present invention to solve the above problems and to provide a method of extracting chrysanthemum chick bone chondroitin extract powder from honeycomb, honeycomb, chrysanthemum, oak tree, A herbal composition for improving liver function, which contains Betaine, Hovenia dulcis extract powder and red ginseng, and a method for producing the same.

In order to achieve the above object, the present invention provides a herbal composition for preventing and treating hepatic function, comprising 1 to 30 parts by weight of gugija, 1 to 30 parts by weight of corn, 1 to 20 parts by weight of corn oil, 1 to 10 parts by weight of red ginseng, 1 to 10 parts by weight of extract of Hovenia dulcis, 1 to 30 parts by weight of honey, 1 to 30 parts by weight of ginkgo nut, 1 to 20 parts by weight of brewer's yeast, 1 to 20 parts by weight of jujube 1 to 20 parts by weight of reed, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of oak tree, 1 to 20 parts by weight of valerian extract powder, 1 to 20 parts by weight of chest chest cartilage extract powder and 1 to 10 parts by weight of onion And the like.

The present invention may further include any one of a carrier, an excipient, and a diluent in the composition.

In addition, the present invention relates to a method for producing a green tea, which comprises 1 to 30 parts by weight of gentiana, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 20 parts by weight of reeds, 1 to 20 parts by weight of corn oil, 1 to 20 parts by weight of jujube, 1 to 10 parts by weight of onion, and 1 to 10 parts by weight of red ginseng are dried and crushed by a pulverizer to homogeneously mix;

(2) a step of extracting 40 to 55 parts by weight of the mixed dry chemical and 45 to 60 parts by weight of purified water from a distillation extractor at a high temperature (95 to 120 ° C) for a long time (4 to 8 hours)

10 to 90 parts by weight of the complex extract of the above two stages is added to a stirrer and 1 to 20 parts by weight of honey, 1 to 10 parts by weight of valerian extract powder, 1 to 10 parts by weight of chest chest cartilage extract powder, 1 to 10 parts by weight of beer yeast powder 1 to 10 parts by weight of Betaine, 1 to 20 parts by weight of Hovenia dulcis extract powder, 1 to 10 parts by weight of liquid phase mortar and 1 to 10 parts by weight of guar gum are homogeneously added at a temperature of from 40 to 90 ° C ) Speed; And a method for manufacturing a herbal composition for improving liver function, comprising the step of preparing the composition.

In addition, the method may further include a step of mixing any one of the carrier, excipient, and diluent with the three-step composition.

According to the present invention, by including an active ingredient such as gojiwon, mackerel, and valerian extract, it can be usefully used for improving liver function by lowering the value of AST, ALT and γ-GTP, which are liver function values, .

The present invention relates to a herbal composition for improving liver function and a method for preparing the same, and more particularly, to a herbal composition for improving liver function comprising ginseng, jalapeno extract, , Brewer's yeast, chest chest cartilage extract powder, honey, betaine, hinoki extract powder and red ginseng, and a herb composition for improving liver function and a preparation method thereof.

Hereinafter, the present invention will be described by way of examples. It will be understood that the invention is not limited to the embodiments described below and that various modifications are possible to those skilled in the art to which the invention pertains.

Hereinafter, the natural products used in the present invention will be briefly described.

Chicken Sternum Cartilage (Chicken Sternum Cartilage) is a type of collagen-type two-type structure composed of protein, chondroitin sulfate, moisture, phosphorus and ash. Collagen is a kind of important protein that constitutes the living body. It is widely distributed in the skin and articular cartilage, and is distributed widely in the ligaments, bones, and blood vessels. It is classified into type 1, type 2, type 3 to type 20 according to the distribution and properties in vivo. Among them, the major component of joints is collagen of type 2, except for water. This ingredient acts as a lubricant for the cartilage, and it has been reported that it attracts moisture in the tissue to help soften the movement of joints, thereby alleviating the pain of osteoarthritis and rheumatism, and slowing degeneration of cartilage. (Xv Jiqu et al., CHINESE JOURNAL OF PUBLIC HEALTH, 2006. 22). In addition, there is a record of prescription of "Huangzhong" rib (黄 雌 鷄 rib bone) on "Huancho" which is an old Chinese medicine book.

Valeriana fauriei is the root and rootstock of Valeriana faurieivar. Dasycarpa Hara, Valeriana officinalis L. var.latifoliaMiq. It is a semi-ominous herbaceous plant native to the mountains, riverside, and streams, and has a unique flavor. It is a perennial herbaceous plant with martitis, about 1 meter in height, with leaves facing each other and an idyllic leaf. From May to August, light red flowers bloom and the fruit is feathery. The roots are medicinal and are grown in mountain wetlands, distributed in Korea, Japan, Taiwan, and northeastern China.

Gugija is a leaf, leaf, and shrub of branches, and is known as a goji tree. It grows throughout the country. In one room, it is called leaf, leaf, fruit, and root. It contains amino acids and vitamins. It is used for dementia, conjunctivitis, fatigue and dizziness. It has been called as a potion of a non-living person since ancient times, and it has effects on tonic, gangjeong, and dryness. It is also good for improvement of fragility and dizziness. Gugija contains vitamins, rutin, betaine, and amino acids, so it is highly effective as a tonic, and is effective in preventing arteriosclerosis and hypertension.

(Valeriana offcinails L.) It is a dry powder after extracting roots part with ethanol and mixing with dextrin. It is a powder that has a strong central nervous system stability and a feeling of stability in brain waves (α-wave) To help reduce stress and reduce stress.

Betaine is widely distributed in plants and animals and is synthesized in vivo through the irreversible oxidation of choline. Betaine plays a role in transferring methyl groups to homocysteine and converting it into methionine in the sulfur transport pathway. The betaine includes betaine anhydride, betaine hydrate, or any other pharmaceutically acceptable salt thereof that may be beneficial to betaine when dissolved in hydrochloride or other water. The betaine may be any of those extracted or synthesized from natural products by known methods, and the production method and origin of the betaine are not limited.

Actinidia polygama is a fruit of Gentiana, a deciduous vine plant belonging to Actinidiaceae, which is composed of sucrose, mucilage, starch, protein, tannin, organic acid, vitamin C, vitamins A, and vitamin P, and the known effects include cicada, juvenile fever and urological stone treatment (ubiquitous stone, ubiquitous stone, Young Lim, p386-387, 1998).

Brewer's yeast is responsible for fermenting beer. When beer is separated from the beer making process, the beer is opened on the top and the brewer's yeast is submerged on the bottom. Brewey's Yeast). Brewer's yeast has been used for a long time for the purpose of medical treatment and health promotion, but it is getting attention as a high-protein food which activates brain cells by scholars recently.

It is known to have a variety of medicinal effects such as digestion promotion, blood and hematopoiesis, antidiuretic action, muscles of the stomach and limbs, and strength. However, it is not known whether the quince has activity to restrain fatigue or stress.

Nogeun refers to the root of reed which grows wild in Korea. There is no known specific pharmacological activity, nor is there any known activity for restoring fatigue or stress at all. It is known that there is no pharmacological activity such as diuretic action, antipyretic action, liver protective action, none.

Ogapi is a deciduous broad-leaved shrub belonging to Araliaceae such as ginseng. It is also called Ogalli and is also produced in Korea, China and Russia. According to Dong-bo-bo-gang or Bon-gae Gangmok, it has been used for a long time and it is called 'second ginseng' by long-lasting taking the roots, stem and branches of the gangs.

Green tea has been extensively used as a health drink in the private sector and has been widely used by many scholars at home and abroad for the prevention of hypertension and arteriosclerosis, anticancer, antioxidative, diabetic, detoxifying, It is known that it has the effect of preventing cavities. The green tea leaves have 70 to 80 parts by weight of water and the remainder are solids such as polyphenols, caffeine, amino acids, carbohydrates, pigment components (chlorophyll, carotenoids, flavonol derivatives and anthocyanins), organic acids, , And inorganic components.

It is a bark of roots and has no smell. Changgeun sweat, fever, fever, healing headache and stop the thirst. It is used for digestion, headache, anemia, dysentery, abdominal pain, dryness, cold, vomiting and bleeding of wife. It blooms raw roots and sucks and drinks. The fruit of the 칡 is called the gag, and it is effective in the diarrhea. The 칡 flower which is a 칡 flower has a unique sweetness, and it releases the digestion and strengthens the intestines.

Pseudoptera (Porphyra vulgaris) is a relative plant belonging to the same genus. This medicine has a peculiar smell, and the taste is spicy and the quality is warm. It is used for chest leaks caused by mental anxiety, insomnia, easily frightening symptoms, nervous breakdown, myocarditis, postpartum heart disease, heart failure, altitude sickness, menstrual irregularity, stomach cramps, joint points, bruises. Pharmacological actions such as sedation, antipyretic action, hypotension, Gram-positive bacterial inhibitory action, and diuretic action have been reported.

Corn oil is effective for adults and women who pass through the urinary tract of the kidney, especially helps to restore sexual function, stop sweating, heat down and replenish the tongue. It is also effective in frequent urination to urinate too often.

Honey has been known to have the effects of restoring fatigue, preventing and treating anemia, supplying diabetic patients, prevention and treatment of liver diseases, relieving hangover, natural nutritional supplement, beauty effect, infant growth promotion and sterilization effect Fructose, the main component of honey, is used as a raw material for food as a natural sweetener.

Ginseng contains saponin glycoside (saponin glycoside), long senoside, steroid, vitamin B group, choline and the like. It can be used as a revitalizing agent for depression of metabolic function by weakness of function such as stomach and the like and it is used as a medicine for depression, dyspepsia, vomiting, chest pain, diarrhea, appetite, It is also used for sluggishness.

Jujube (Zizyphus jujuba Mill var. Inermis Rehder) is a broad-leaved arboreous tree belonging to the family Seagaceae. It is used for medicinal and edible purposes. It has a height of 10m and its branches are slippery and prickly. The flowering period is June, and the fertilization period is from September to October. It is distributed in the vicinity of the marlon and in the field and it is distributed throughout the country and it is possible to cultivate.

Onions are very useful in women who are at the age of menopause, and onions can help reduce bone loss and reduce the likelihood of osteoporosis. The onion, which contains a lot of quercetin, lowers the bad cholesterol level in the blood and has the effect of decomposing the fat component, which helps the circulation of the blood, effectively preventing arteriosclerosis and various vascular diseases such as hypertension and hyperlipemia .

In order to accomplish the object of the present invention, there is provided a method for producing a chrysanthemum extract, comprising the steps of: extracting ginkgo nut, gugija, quince tree, oak tree, marine oil, reed, green tea, onion, jujube, valerian extract powder, brewer's yeast, Extracts of red ginseng, wood extract powder and red ginseng were mixed to prepare a herbal composition. Then, a quantitative and qualitative analysis test was conducted, and a hepatic function improvement test was conducted by a human body simple test. As a result, It was achieved by confirming that the symptoms of dysfunction can be alleviated.

The compositions of the present invention may further comprise suitable carriers, excipients and diluents conventionally used in the manufacture of pharmaceutical compositions.

The present invention relates to a method for producing a starch powder comprising 1 to 30 parts by weight of gugija, 1 to 30 parts by weight of corn oil, 1 to 20 parts by weight of corn oil, 1 to 20 parts by weight of betaine, 1 to 10 parts by weight of red ginseng, 1 to 30 parts by weight of honey, 1 to 30 parts by weight of gentian fruit, 1 to 20 parts by weight of brewer's yeast, 1 to 20 parts by weight of jujube, 1 to 20 parts by weight of reed, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of valerian extract powder, 1 to 20 parts by weight of chest chest cartilage extract powder and 1 to 10 parts by weight of onion as an active ingredient, a pharmaceutical composition for improving liver function, a food composition, Health functional food composition.

Hereinafter, preferred embodiments of the present invention will be described. However, the following examples are given to aid understanding of the present invention, and the present invention is not limited to the following examples.

< Example  1 to 5: Preparation of the herbal composition for improving liver function according to the present invention>

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Jindiae 2 4 10 15 15 Gugija 3 20 5 One 20 Quince tree 3 5 5 One 5 Apricot tree 3 5 5 One 5 Reed 10 5 5 5 5 green tea 10 5 2 5 10 Corn oil 10 5 2 5 5 Jujube 10 5 2 5 5 onion One One 2 One 2 Red ginseng One One 0 One One Purified water To. 100 To. 100 To. 100 To. 100 To. 100

Table 1. Ingredient Content Table of Oriental Compositions (unit: parts by weight)

According to the present invention, according to the above Table 1, 1 to 30 parts by weight of gentiana, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 20 parts by weight of reed, 20 to 50 parts by weight of soybean oil, 1 to 20 parts by weight of soybean oil, 1 to 20 parts by weight of jujube, 1 to 20 parts by weight of jujube, 1 to 10 parts by weight of onion, and 1 to 10 parts by weight of red ginseng are dried, crushed by a pulverizer, homogeneously mixed, 40 to 55 parts by weight of water and 45 to 60 parts by weight of purified water are added and the mixture is extracted at a high temperature (95 to 120 ° C) for a long time (4 to 8 hours) in a distillation extractor.

In the case of the concentrated extract, it is preferable to apply a temperature of 100 ° C or higher in order to separate the extraction component and the distillation effective components. Therefore, the high temperature optimum temperature is preferable, and the extraction within 4 hours within a short period of time is too dilute, When extracting for a long time longer than the time, the amount of distillation becomes too much and the extract is reduced.

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Valerian extract powder 0 4 3 15 15 Chest chest cartilage extract powder 3 20 One One 20 Beer yeast powder 5 5 One One 5 Betaine One 5 5 One 5 Houttree tree extract powder 10 5 0 5 5 Liquid mortgage 10 5 2 5 10 Guar gum 10 5 2 5 5 honey 10 5 3 5 5 Table 1 Extract To. 100 To. 100 To. 100 To. 100 To. 100

Table 2. Ingredient Content Table of Oriental Compositions ( Unit: parts by weight )

Next, the complex extract (10-90 parts by weight) was added to a stirrer, and 1 to 20 parts by weight of honey, 1 to 10 parts by weight of valerian extract powder, 1 to 10 parts by weight of chest chest cartilage extract powder, 1 to 10 parts by weight of betaine, 1 to 20 parts by weight of Houttuynia cordata extract, 1 to 10 parts by weight of a liquid phase mortar and 1 to 10 parts by weight of guar gum are added thereto and homogeneously mixed at a middle temperature (40 to 90 ° C) (1000 to 4000 rpm).

When the mixing speed of the mixer is too slow, the extract of Table 1 and the components of Table 2 are not mixed with the mortar or guar gum raw materials which act as an incrementer and sink to the bottom due to specific gravity.

<Experimental Example 1: Experimental Effect of Liver Function Improvement in Example 3>

The most common test for liver function improvement is a test for changes in blood biochemical values. Serum AST, especially ALT, is a sensitive test for hepatic disorders because it has high enzyme content in the liver as well as easy anatomical leakage of the enzyme into the blood. In the supernatant fraction of normal hepatocytes, AST <ALT. In addition, AST has a shorter half-life of blood, so the enzyme of the serum becomes AST <ALT, unlike other organ diseases in liver failure.

However, in liver cirrhosis or hepatocellular carcinoma, the enzymatic activity in pathologic cells due to blood flow disorder is AST> ALT. As a result, the serum enzyme activity is often AST> ALT. In cholestatic lesions, the increase of γ-GT and ALP activity is remarkable compared to the increase of AST and ALT. AST and ALT activity The reference range is slightly different depending on the measurement method. AST 8 ~ 32 IU / L and ALT 4 ~ 30 IU / L are used as the reference range. AST, and ALT activity, there are few differences according to gender and age, and there is little difference according to pregnancy. However, there is also a report that the latter is significantly higher in the age group below 30 and above 30. Men tend to have a slightly higher tendency than women, but there is no significant difference. [Reference to the Health Functional Food Test Guide, 2004]

Serum enzyme test was performed to examine the effect of the liver function test. Five patients were examined by a Korean oriental medical practitioner who had systemic disability, liver pain, anorexia, and whitish symptoms. For the test, 30-day doses were taken 20 ml once a day in the evening two hours before sleep. The liver function improvement effect was compared with the liver function values obtained at the time of selecting the final subject and the liver function values obtained by fasting blood collection at the 30th day after the end of the sample intake. Hepatic function index analysis was performed by centrifuging 3 ml of whole blood at 2,500 rpm for 10 minutes, separating the serum, and then using AST (Aspartate aminotransferase), ALT (Alanine aminotransferase), γ -GTP (? -Glutamyl transpeptidase) was measured.

Before and after the administration, paired t test was performed. As shown in the following Table 3, the composition of the present invention showed a significant decrease in the hepatic index (AST, ALT, γ-GTP) and statistically significant (p <0.05) γ-GTP.

Example 3 Shi Shih-zhuang (0 day) After the test (30 days) ALT 57.35 ± 25.68 34.62 + - 21.54 AST 53.25 + - 61.21 37.59 + - 42.66 gamma -GTP 89.17 + - 41.65 40.81 + - 12.37

As described above, according to the present invention, by containing effective ingredients such as herbal medicines, it is possible to reduce the levels of AST, ALT, and γ-GTP, which are liver function values, .

The above-described embodiments are illustrative and those skilled in the art will be able to make various modifications and alterations to the disclosed embodiments without departing from the technical idea of the present invention. The scope of this invention is not limited by these variations and modifications.

Claims (4)

1 to 30 parts by weight of corn oil, 1 to 30 parts by weight of corn oil, 1 to 20 parts by weight of corn oil, 1 to 20 parts by weight of betaine, 1 to 30 parts by weight of honey, 1 to 30 parts by weight of ganoderma, 1 to 20 parts by weight of jujubes, 1 to 20 parts by weight of jujubes, 1 to 20 parts by weight of reeds, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of oak tree, 1 to 20 parts by weight of valerian extract powder, And 1 to 10 parts by weight of an onion. &Lt; Desc / Clms Page number 24 &gt; The method according to claim 1,
The composition of claim 1, further comprising a carrier, an excipient or a diluent. 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of green tea, 1 to 20 parts by weight of corn oil, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 30 parts by weight of ginger, 1 to 20 parts by weight of jujube, and 1 to 10 parts by weight of onion are dried and crushed by a pulverizer to homogeneously mix;
(2) a step of extracting 40 to 55 parts by weight of the mixed dry chemical and 45 to 60 parts by weight of purified water from a distillation extractor at a high temperature (95 to 120 ° C) for a long time (4 to 8 hours)
10 to 90 parts by weight of the complex extract of the above two stages is added to a stirrer and 1 to 20 parts by weight of honey, 1 to 10 parts by weight of valerian extract powder, 1 to 10 parts by weight of chest chest cartilage extract powder, 1 to 10 parts by weight of beer yeast powder 1 to 10 parts by weight of betaine, 1 to 10 parts by weight of liquid phase mortar and 1 to 10 parts by weight of guar gum, and mixing the mixture homogeneously at a middle temperature (40 to 90 ° C) (1000 to 4000 rpm).
Wherein the method comprises the step of administering the composition to a subject in need thereof. The method of claim 3,
A method for preparing a herbal composition for improving liver function, comprising the step of mixing the composition of step (3) with a carrier, an excipient or a diluent.