KR100915893B1 - Herb Extracts and Functional Food using the same for Obviating and Curing Hangover - Google Patents

Abstract

The present invention relates to herbal extracts for preventing and eliminating hangovers and functional foods using the same. More specifically, the present invention relates to herbal extracts for hangover prevention and remedy, and functional foods using the same, including oak bark, pine needles, licorice, brown root, baekhyeop, wormwood, gold and silver, the extract of Chinese quince.

According to the present invention, it is possible to effectively prevent and eliminate hangovers while ensuring stability.

Hangover, herbal extract, functional food, detox, alcohol

Description

Herb Extracts and Functional Food using the same for Obviating and Curing Hangover}

1 is a graph showing the weight change of Sprague-Dawley in the case of administering the extract and dioxin prepared according to an embodiment of the present invention.

Figure 2 is a graph showing the weight change of Sprague-Dawley organs in the case of administering the extract prepared by the embodiment of the present invention and dioxin.

The present invention relates to herbal extracts for preventing and eliminating hangovers and functional foods using the same. More specifically, the present invention relates to herbal extracts for hangover prevention and remedy, and functional foods using the same, including oak bark, pine needles, licorice, brown root, baekhyeop, wormwood, gold and silver, the extract of Chinese quince.

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About 10% of the alcohol absorbed through drinking is excreted in vitro through breathing or urine, and the rest is metabolized in the gastric mucosa and liver. In the body, ethyl alcohol is first decomposed to acetaldehyde and then decomposed again to acetic acid. Acetaldehyde, an intermediate in the decomposition process, can cause sweating, skin fever, nausea, vomiting, and the exact cause is not known. It is presumed that the main cause of is acetaldehyde. In addition, in the case of modern people, drinking is a frequent side for various reasons, and such frequent drinking eventually causes the body to become a cause of various diseases. Currently, many techniques have been disclosed for eliminating hangovers, but most of them have not been commercialized due to various reasons, such as lack of scientific proof or rare raw materials.

Therefore, there is an urgent need for the development of drugs and foods that can solve the above problems, that is, hangover relief without side effects.

An object of the present invention is to provide a herbal extract and a functional food using the same, which has an excellent effect on preventing and eliminating hangovers while ensuring stability.

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The above and other objects can be achieved by the present invention described below.

The present invention relates to herbal extracts for preventing and eliminating hangovers and functional foods using the same. More specifically, the present invention relates to herbal extracts for hangover prevention and remedy, and functional foods using the same, including oak bark, pine needles, licorice, brown root, baekhyeop, wormwood, gold and silver, the extract of Chinese quince.

Hereinafter, the present invention will be described in detail.

The present invention is the extract of oak bark, pine needles, licorice, brown root, baekryeop, mugwort, gold and silver quince, as a main component, first of all looks at what the composition of the above, and how it works.

Oak is a plant belonging to oak and oak, distributed from temperate to tropical in the northern hemisphere and easily available around us. From ancient times, oak has been used to make vinegar liquor, which is applied to various folk remedies.

Pine needles have been used for medicinal and health foods in traditional medicine and private medicine. According to the agreement, pine needles are known to be effective in treating gastrointestinal diseases, stroke, hypertension, neuralgia, and asthma. Pine needles differ slightly depending on the region and season of harvest, but in general, Terpenetine Oil, Cineol, Salinigrin, Retene, Coniferin and Pi-Simen P-Cymen), Densipimaric Acid, and chlorophyll, various amino acids, crude fat, phosphorus, iron, enzymes, minerals, vitamin A, vitamin C, and vitamin P. Terpennetine oil, the main component of pine needles, contains alpha-pinene, kphene, beta-pinene, beta-myrcene, beta-felradene Shellandrene), which expands capillaries, promotes blood circulation, and, in addition to chlorophyll, another component of pine needles, has different but inhibitory effects on E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa. In addition, unsaturated fatty acids contained in essential oils lower serum cholesterol levels, which significantly lower blood pressure, and have antibacterial and bactericidal effects against eczema and negative pathogenic fungi occurring on the skin.

Licorice (Glycyrrhiza uralensis Fisch, Glycyrrhiza glabra L.) is a perennial herbaceous plant belonging to Leguminosae, whose roots and stems are used for medicinal and edible food. Licorice has long been used as an antidote, antitussive expectorant, laxative, peptic ulcer and gastric ulcer in oriental medicine and folk medicine. It has been known. Licorice extracts include Glycyrrhizin, Glycyrrhetic Acid, Licoricidin, Hispaglabridin A, Hispaglabridin B, and Glabridine (Glycyrrhizin). Glabridin, 4-O-methylglabridin, 4-isoprenylchalcone derivative, Isoliquiritigenin, Formononetin and the like. Glycyrrhizin in the licorice extract acts as an anti-inflammatory, detoxifying, anti-ulcer, and hydrolyzate hormone.Glabridin inhibits the oxidation of Low Density Lipoprotein, which is harmful to the body. It is known to be effective.

The root of root is the root of the pueraria radix. It is known that there are effects such as branch offices. Brown root contains a large amount of isoflavonoide, and the pharmacological effects related to the root are known as anti-alcoholic poisoning (Antidipsotropic), liver protection, hangover suppression, and antioxidant. In addition, it is known that there is a relaxation action of smooth muscle, coronary artery dilation and blood pressure drop in the cardiovascular system, heart rate control action, platelet aggregation inhibitory action, strong blood sugar action, antipyretic action.

The cypress is the cypress ( Thuja) Orientalis L.) refers to the young branches and leaves. The herbaceous lobe from the oriental medicine to lower blood fever, nosebleeds, hemorrhage, urine bleeding, uterine hemorrhage, seawater, asthma, sputum, hair loss, seborrheic dermatitis, traumatic bleeding. In other words, the lateral lobe has been known to reduce bleeding time, cough, expectorant action, and to reduce blood pressure, antibacterial action, seawater and asthma.

Mugwort (mugwort) is a perennial plant with high propagation power, which is widely distributed in Asia, Europe, Japan, China, etc., and belongs to the Carduaceae. In oriental countries including Korea, it has been used as a medicine for hemostatics, digestion, lower abdominal pain, worms, odor removal, gastrointestinal diseases, constipation, neuralgia, cold diseases, women's diseases, and asthma, etc. It has also been widely used as a submaterial. Mugwort is known to have various physiological activities such as insecticide, antibacterial and anti-tumor in its fragrance or essential oil like other spices, and its main ingredients are cineole and α-tujon ), Sesquiterpene, sesquiterpene alcohol, sesquiterpene alcohol, camper, terpinene-4-ol, coumarin, capillin, Borneol and the like.

Lonicerae flos is a bud of the locust shrub Loncera japonica, a plant of the Caprifoliaceae family, and is used for diuresis, dry stomach, arthritis, purulent dermatitis and bronchitis in herbal and folk medicine. The main components of gold and silver are known as tannin, inositol, sterol, chlorogenic acid, isochlorogenic acid, apigenin and quercetin. have.

Chinese quince (Chenomeles sinensis) is native to China and is a fruit belonging to the Rosaceae family that was cultivated before Goryeo in Korea. The main components of Chinese quince are 74-85% moisture, 13.4-20.7% sugar, 1.3-4.4% fiber and 0.3-0.7% ash. Fruits contain saponin, malic acid, tartaric acid, citric acid, vitamin C, flavonoids and tannins, and seeds contain hydrocyanic acid. Chinese quince has long been used as a cough for phlegm and bronchitis. In addition, quince is effective in dysentery, diarrhea and abdominal pain, promotes digestion and relaxes the stomach, and it is effective for muscle spasms and joint pain caused by anemia by relieving the spores, hiccups, phlegm and hangover. It is said that it is good for action, heat illness.

The present invention, each composition constituting the herbal extracts for preventing and eliminating hangovers and functional foods using the same, based on the dry weight of each, 25 to 75 parts by weight of oak bark, 30 to 90 parts by weight of pine needles, licorice 6 to 18 parts by weight, brown root 30 to 90 parts by weight, 6 to 18 parts by weight of the locust leaf, 6 to 18 parts by weight of wormwood, 1 to 3 parts by weight of sterling silver, 2 to 6 parts by weight of quince, preferably 50 parts by weight of oak bark , 60 parts by weight of pine needles, 12 parts by weight of licorice, 60 parts by weight of root roots, 12 parts by weight of baekryeop, 12 parts by weight of wormwood, 2 parts by weight of gold and silver, and 4 parts by weight of Chinese quince. As described above, the composition of the herbal medicines used in the present invention has a safety as a result of long-term use, and has the advantage of no toxicity and side effects, which are various side effects such as incompatibility of various toxic and physiological control functions when using chemicals. This can be a big advantage when considering.

In addition, the herbal extract for preventing and eliminating hangover according to the present invention, after adding 50 to 150 times the total weight of the oak bark, pine needles, licorice, brown root, baekyeop, mugwort, gold and silver quince, which is subject to extraction, The extraction is performed at room temperature of 20 to 40 ° C. for at least 24 hours, followed by extraction at a high temperature of 40 to 80 ° C. for at least 24 hours, and finally, the vapor is heated to 100 ° C. to be collected and cooled. As described above, the extraction is sequentially performed at a temperature of 20 to 40 ° C. for 24 hours or more and at a high temperature of 40 to 80 ° C. for 24 hours to increase the effect of extraction, and the inventors of the present invention perform a plurality of repeated experiments. I found it.

In the present invention, herbal extracts for preventing and eliminating hangovers and functional foods using the same can be prepared in any form, such as liquid, granular, powdery, gelled, emulsions, tablets, capsules, granules, powders, syrups, etc. It may also be prepared. In addition, herbal extracts and functional foods using the same according to the present invention can prevent and relieve hangover as well as prevent detoxification of toxic substances such as dioxins and deterioration of liver function due to alcohol intake. An example will be described later.

Liquid compositions such as emulsions and syrups can be prepared using water, sugars, oils, vitamins, pigments, minerals, and preservatives as additives.Capsules, tablets, powders, granules, etc. are excipients, disintegrants, lubricants, binders. , Surfactants, plasticizers and the like can be used as additives.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples. However, the present invention is not limited by the following Examples and Test Examples.

Example  1: Preparation of herbal extract

250 g of oak, 300 g of pine needles, licorice 60 g, brown root 300 g, white liquor, wormwood 60 g, gold and silver ginseng 10 g, Chinese quince 20 g are mixed in a sealed container, and 100 l of purified water is added to the mixture. Extraction was performed for 24 hours at. The extraction was then completed by heating to 100 ° C. and collecting and cooling the vaporized vapor.

Example 2  : Preparation of Herbal Extracts

In order to remove impurities that may be present in the herbal extract according to Example 1, the extraction was performed twice with ethanol. That is, 1 liter of the herbal extract according to Example 1 was taken, and 1 liter of 100% ethanol was added thereto to make a 50% ethanol solution, which was left at room temperature for 24 hours, followed by filtration and evaporation of ethanol. To 1 liter of 100% ethanol was added again to make a 50% ethanol solution, and left for 24 hours at a temperature of 0-4 ℃, filtered and ethanol was evaporated to obtain a 1 liter of liquid.

Test Example 1  : Stability Test

Experimental animals were used after 1 week of body weight 180-200g (average weight 190g) Sprague-Dawley male rats were purified, and 10 animals were set in each group. The experimental animal breeding room temperature was maintained at 23 ± 2 ℃, humidity 50 ± 20%, and the light / dark cycle was 12 hours. As a result of oral administration of the extract prepared according to Example 1 and 20 mg / kg · day of the extract prepared according to Example 2 to the experimental animal and observing survival (72hr), all survive within a given period. LD ₅₀ could not be observed even at the dose of 10 g / kg · day.

In addition, all of these doses survived even if administered orally continuously for 30 days, and compared with the control group not administered the extract, significant changes in weight and activity could not be detected.

Test Example  2: detoxification test

Experimental animals were used after 1 week of body weight 180-200g (average weight 190g) Sprague-Dawley male rats were purified, and 10 animals were set in each group. The experimental animal breeding room temperature was maintained at 23 ± 2 ℃, humidity 50 ± 20%, and the light / dark cycle was 12 hours. The dioxin detoxification effect of the herbal extract according to the present invention was tested in the above experimental animals. TCDD was used as dioxin. One group (first treatment group) was intraperitoneally administered 1 ug / KG · day of dioxin for 30 days, and the other group (second treatment group) 1 ug / kg · day of dioxin and 20 mg / kg of herbal extracts according to Example 2 Day was intraperitoneally administered for 30 days. Experimental animals that did not receive dioxins and herbal extracts were used as controls.

(1) weight measurement

The body weights of the control group, the first treatment group, and the second treatment group were measured after 5 days, 10 days, 15 days, 20 days, 25 days, and 30 days, respectively, and are shown in Table 1 and FIG. 1 below.

   [Table 1] Weight measurement results

As shown in Table 1 above, in the first treatment group, the growth was slowed compared to the control group, and in particular, when the dioxin was injected for 20 days, the weight was decreased. In the second treatment group, although the growth was slightly slower than the control group, the slowdown was considerably alleviated when compared to the first treatment group. Therefore, it can be seen that the herbal extract according to the present invention is effective in preventing growth slowdown and weight loss by dioxin.

(2) weighing organs

30 days after the start of the experiment, the weights of the liver, kidney, and testicles were measured for the control group, the first treatment group, and the second treatment group, and are shown in Table 2 and FIG. 2 below.

   [Table 2] long-term weight measurement results

As shown in Table 2, in the first treatment group treated with only dioxin, the weights of the liver, kidney, and testes were significantly reduced. Compared with the control group, the liver was about 62%, the kidney was about 70%, and the testicles were only about 50% by weight. In the second treatment group administered dioxins and herbal extracts at the same time, there was a decrease in weight compared to the control group, but the reduction was significantly reduced compared to the first treatment group treated with dioxin alone. Compared to the control group in the second treatment group, it was found that the weight of the liver was about 91%, the kidney was about 88%, and the testicles were about 94%. Therefore, it can be seen that the herbal extract according to the present invention is effective in preventing weight loss and deterioration of organs by dioxin.

Test Example  2: prevention of liver damage and alcohol degradation efficacy test by alcohol consumption

(1) alcohol decomposition effect

Experimental animals were used after a week-long purifying Sprague-Dawley male rat body weight 180-200g (average weight 190g) Sprague-Dawley male rats, the experiment was set to 10 dogs in each group. The experimental animal breeding room temperature was maintained at 23 ± 2 ℃, humidity 50 ± 20%, and the light / dark cycle was 12 hours. The experimental animals were tested for the effects of the present invention on alcohol degradation. One group (first treatment group) was orally administered with 20mg / kg of bottled water, and after 1 hour, 25% ethyl alcohol 2mg / kg was orally administered, and the other group (second treatment group) had the herbal extract according to Example 1 above. After oral administration of 20 mg / kg, 2 mg / kg of 25% ethyl alcohol was orally administered 1 hour later. 2 hours after the administration of ethyl alcohol, blood was collected from the orbital vein, centrifuged at 3,000 rpm for 10 minutes, the supernatant was separated, and the blood alcohol concentration was measured using an ethanol quantitative kit (Sigma 332-A, USA). As a result, the alcohol concentration (mg / ml) of the first treatment group was 0.07 ± 0.007, and the alcohol concentration of the second treatment group was 0.02 ± 0.002. As shown in the above measurement results, it can be seen that the blood alcohol concentration is significantly lower in the second treatment group in which the alcohol and the extract according to the present invention are administered in comparison with the first treatment group in which only the alcohol is administered. Therefore, it can be seen that the extract according to the present invention has an excellent effect on promoting degradation in alcohol.

(2) liver protection effect

Experimental animals were used after 1 week of body weight 180-200g (average weight 190g) Sprague-Dawley male rats were purified, and 10 animals were set in each group. The experimental animal breeding room temperature was maintained at 23 ± 2 ℃, humidity 50 ± 20%, and the light / dark cycle was 12 hours. The experimental animals were tested for the protective effect of the present invention against liver damage caused by alcohol intake. One group (first treatment group) was orally administered with 25% ethyl alcohol 2mg / kg · day for 30 days, and the other group (second treatment group) 25% ethyl alcohol 2 mg / kg · day and the herbal medicine according to Example 1 Extract 20mg / kg · day was orally administered for 30 days. Experimental animals that did not receive alcohol and herbal extracts were used as controls.

After 30 days from the start of the experiment, the livers of the animals were excised to measure GOP and GTP using SF / IC (CH-16, Texas Intern), and the results are shown in Table 4 below.

   [Table 3] GOP / GTP Measurement Results

As shown in Table 3 above, it can be seen that the values of both GOP and GPT are significantly lower in the second treatment group in which the alcohol and the composition according to the present invention are simultaneously administered compared to the first treatment group in which only the alcohol is administered. Therefore, it can be seen that the extract according to the present invention has an excellent effect in preventing liver damage by alcohol.

Example  3: preparation of beverage having alcohol decomposition and hangover removal function

Functional beverages were prepared by adding various additives to the herbal extracts of Examples 1 and 2. Each specific composition is shown in Table 4 below.

   [Table 4] Composition ratio of functional drinks

Test Example  3: Test of Alcohol Degradation and Hangover Efficacy

(1) alcohol degradation efficacy test

After 5 hours of drinking 20ml of alcoholic beverages for 21 hours, the alcohol concentration meter (CA-2000) Blood alcohol concentration was measured at 1 hour intervals by using the above as a comparative example.

After two days, the male and female to drink 100ml of the beverage of Preparation Example 1 of Example 3 first, and then to drink alcoholic beverages 360ml of 21% alcohol content for 1 hour, 1 hour using an alcohol concentration meter Blood alcohol concentration was measured at intervals (Measurement Example 1).

After two more days, the men and women were allowed to drink 360 ml of alcoholic beverages containing 21% alcohol for 1 hour, and then drink 100 ml of the beverage of Preparation Example 1 of Example 3, and then drink the alcohol concentration meter for 1 hour. Blood alcohol concentrations were measured at intervals (Measurement Example 1 ').

In the same manner as in Preparation Example 1 was also tested for Preparation Examples 2 to 4 of Example 3 to determine the blood alcohol concentration (Measuring Examples 2 to 4 '). The average value of the measurement results is shown in Table 5 below.

   [Table 5] Blood alcohol concentration measurement results

As shown in Table 5 above, it was found that the blood alcohol concentration was lowered when the alcohol and the functional beverage were ingested in comparison with the comparative example in which only the alcohol was ingested. As can be seen from the above table, the content of the composition of the above embodiment in the functional beverage was found to lower the blood alcohol concentration than the case of the composition of 25wt%. However, as can be seen in the above table, if the content of the composition is the same, it can be seen that whether the beverage is added to the extract of Example 1 or the beverage is added to the extract of Example 2 does not affect the alcohol concentration. In addition, when the blood alcohol concentration was measured after 3 hours, it was shown that drinking the above beverage before ingesting the alcohol lowers the blood alcohol concentration, which is due to the relatively long time for the function of the beverage to be expressed in the body. It seems to be.

(2) Hangover Efficacy Test

Nine hours after the completion of the "(1) alcohol degradation efficacy test", that is, 12 hours after alcohol intake, the participants were evaluated for the degree of hangover and headache, and the results are shown in Table 6 below. The evaluation of hangover and headache was performed with respect to "Measurement example 1, 2, 3, 4" of the "(1) alcohol degradation efficacy test". The degree of hangover and headache were divided into none (5), none (4), moderate (3), mild (2), and severe (1). The results were expressed as mean values.

   [Table 6] Hangover and headache evaluation results

As shown in Table 6 above, it was confirmed that the degree of hangover and headache was remarkably alleviated when the alcohol and the functional beverage were ingested in comparison with the alcohol-only comparative example.

As described above, in the case of the present invention, herbal extracts for preventing and eliminating hangovers and functional foods using the same, it is possible to effectively prevent and remove hangovers while ensuring stability.

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Claims (5)

Herbal medicine extract for preventing and eliminating hangover, which is mainly composed of extract extracted from herbal medicine consisting of oak bark, pine needles, licorice, brown root, egret, wormwood, gold and silver quince and Chinese quince The method of claim 1, The composition ratio of each component is based on the dry weight of each component, 25 to 75 parts by weight of oak bark, 30 to 90 parts by weight of pine needles, 6 to 18 parts by weight licorice, 30 to 90 parts by weight of brown root, 6 to 18 parts by weight of leafy leaf Boo, Mugwort 6 to 18 parts by weight, gold and silver coins 1 to 3 parts by weight, Chinese medicinal extract for hangover prevention and remedy, characterized in that 2 to 6 parts by weight quince 25 to 75 parts by weight of oak bark, 30 to 90 parts by weight of pine needles, 6 to 18 parts by weight of licorice, 30 to 90 parts by weight of brown root, 6 to 18 parts by weight of leafy leaves, 6 to 18 parts by weight of wormwood, 1 to 1 gold To the herbal medicine having a composition ratio of 3 parts by weight, quince 2 to 6 parts by weight, purified water of 50 to 150 times the total weight of the herbal medicine was added and extracted at room temperature of 20 to 40 ° C. for at least 24 hours, followed by 40 to 80 ° C. Herb extract for hangover prevention and remedy produced by extracting at high temperature for more than 24 hours and finally collecting steam vaporized by heating to 100 ℃ Functional food for preventing and eliminating hangover, characterized in that it contains the herbal extract according to any one of claims 1 to 3 as an active ingredient. delete

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