CN103381222A - Plant radix-tetrastigmae gaseous preparation and preparation method - Google Patents
Plant radix-tetrastigmae gaseous preparation and preparation method Download PDFInfo
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- CN103381222A CN103381222A CN2012101442895A CN201210144289A CN103381222A CN 103381222 A CN103381222 A CN 103381222A CN 2012101442895 A CN2012101442895 A CN 2012101442895A CN 201210144289 A CN201210144289 A CN 201210144289A CN 103381222 A CN103381222 A CN 103381222A
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- radix
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- apioris fortunei
- lespedezae buergeri
- tetrastigmae
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a plant radix tetrastigmae, a medicine gaseous preparation (a spray and an aerosol) produced from a radix tetrastigmae extraction by taking a water and/or alcohol extraction of a pharmaceutical composition containing a raw material radix tetrastigmaeas an active ingredient, and a preparation method. The gaseous preparation is characterized in that: 1, taking radix tetrastigmae as a main raw material, adding auxiliary materials comprising poloxamer, povidone (PVP), alcohol, xylitol, glycerol, menthol and the like, performing extracting to prepare the spray; 2, taking radix tetrastigmae as a main raw material, adding auxiliary materials comprising poloxamer, hydroxyethyl cellulose, azone, alcohol, glycerol, borneol, tween-80, dementholized peppermint oil and the like, performing extracting to prepare the aerosol. The plant radix-tetrastigmae gaseous preparation has a new dosage form and is dosed through mucosa, and has the advantages of being convenient to carry, easy to locate and dose, and improved in pharmaceutical effect and availability.
Description
Technical field
The present invention relates to the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract and make the pharmaceutical gas preparation, by a kind of novel form of mucosa delivery, the invention still further relates to the preparation method of this pharmaceutical gas preparation.
Background technology
The present invention relates to the main component Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix Apioris Fortunei (Radix Lespedezae Buergeri) is vitaceae, has another name called gold thread hoist herb and all can be used as medicine, and is best with the medicinal effects of underground tuber and fruit.The main place of production in Southwestern China section and Anhui, Zhejiang, especially produce with Zhejiang best, because the growth conditions harshness is rare medical material.Radix Apioris Fortunei (Radix Lespedezae Buergeri) contains the nutritional labeling of a large amount of raising immunity such as polysaccharide, Saponin and aminoacid, and contain the organic principles such as flavonoid, steroid compound, tool heat-clearing and toxic substances removing, anti-inflammation, antiviral, expelling phlegm for arresting cough, the analgesia of bringing down a fever, promoting blood circulation by removing wind, the spleen invigorating effect of regulating the flow of vital energy, it is composite natural medical material simply, can be considered natural antibiotics, only had single oral and outer application mode in the past, reached clinical effectiveness by this dosage form mucosa delivery
The object of the invention is to provide that a kind of use is easy to carry, and onset is rapid, and determined curative effect is used for Radix Apioris Fortunei (Radix Lespedezae Buergeri) gas preparation of anti-inflammation, antiviral, analgesia detumescence and preparation method thereof.based on clinical circular for confirmation, it is by antibacterial that all diseases are as above felt wind and cold etc., the virus mucosa is invaded and is caused, furuncle carbuncle can be infiltrated by epidermis administration mucosal tissue and be realized the pain relieving suppuration, the convergence granulation promoting, relate to a kind of gas dosage form by the mucosa delivery mode according to the composite natural herbal pharmacology and make up the tradition deficiency to expand clinical practice, this dosage form is that aerosol type and aerosol can be used for the mucosal sites such as oral cavity by gas with various dosage form utensil carrier, reach and prevent and treat the upper respiratory tract infection effect, also furuncle pus can be used for outward swollen, this dosage form is acted on the Chinese medicine traditional idea, the approach disease preventing and treating of using the biological mucosa adhesion mechanism to open up an origin produce effects in today of abuse of antibiotics is gone after profits and advoided disadvantages favour in the patient, this class gas dosage form is used easy to carry, be easy to administration, focus is determined directly to infiltrate in the location, the administration localization can be used for the position, specific region according to patient self, medicine-feeding part extends holdup time raising drug effect and drug utilization degree.
Summary of the invention
Spray of the present invention comprises following extracting method and preparation component:
50%2-3 times of lixiviate of the former medicine 3kg of Radix Apioris Fortunei (Radix Lespedezae Buergeri) ethanol 2 times, the supernatant of 2 extractions is mixed, and it is standby that recovery ethanol is made 1000ml stock solution
Formulation components is as follows:
Purified water adds polyvidone PVP to dissolving fully in right amount, adds Radix Apioris Fortunei (Radix Lespedezae Buergeri) stock solution stand-by, by formula ratio dissolving Mentholum, poloxamer, glycerol mixing add stir evenly in the Radix Apioris Fortunei (Radix Lespedezae Buergeri) mixed liquor standby.Be filled into pressure seal mouth in aseptic pump formula spray nozzle bottle, spiral cover sealing.
Aerosol of the present invention comprises following extracting method and preparation component:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) original liquid component extracting method:
50%8-10 times of lixiviate of the former medicine 1kg of Radix Apioris Fortunei (Radix Lespedezae Buergeri) ethanol 2 times, the supernatant of 2 extractions is mixed, and it is standby that recovery ethanol is made 1: 1 stock solution
Formulation components is as follows:
Purified water adds hydroxyethyl-cellulose to dissolving fully in right amount, add Radix Apioris Fortunei (Radix Lespedezae Buergeri) stock solution, by formula ratio dissolving Borneolum Syntheticum, poloxamer, tween 80, glycerol, Oleum menthae mixing add stir evenly in the Radix Apioris Fortunei (Radix Lespedezae Buergeri) mixed liquor standby, be filled into quantitative valve system pressure gas cylinder, propellant is selected the A-31 normal butane.
1 the present invention is mouthspray type, external aerial fog type by mucosa delivery mode dosage form, has expanded route of administration and mode and has portably used conveniently
2 are helped infiltration according to the composite natural herbal pharmacology, and mucosa attachment techniques adjuvant is used, and can better bring into play drug effect by spray-type and the aerosol-type of mucosa delivery mode.
Example one
Radix Apioris Fortunei (Radix Lespedezae Buergeri) stock solution
Example two
Claims (3)
1. the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract that the pharmaceutical composition that the invention discloses a kind of plant Radix Apioris Fortunei (Radix Lespedezae Buergeri) and Radix Apioris Fortunei (Radix Lespedezae Buergeri) and be raw material is made active component through water and/or alcohol extract is made pharmaceutical gas preparation (spray and aerosol), it is characterized in that it is the gas preparation made from following raw material and preparation method
2. it is characterized in that according to described 1 Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract gas preparation the spray that comprises that the Radix Apioris Fortunei (Radix Lespedezae Buergeri) original liquid component is made, comprise following extracting method and preparation component:
50%3-4 times of lixiviate of the former medicine 3kg of Radix Apioris Fortunei (Radix Lespedezae Buergeri) ethanol 2 times, the supernatant of 2 extractions is mixed, and it is standby that recovery ethanol is made 1000ml stock solution,
Formulation components is as follows:
3. it is characterized in that according to described 1 Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract gas preparation the aerosol that comprises that the Radix Apioris Fortunei (Radix Lespedezae Buergeri) original liquid component is made, comprise following extracting method and preparation component:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) original liquid component extracting method:
50%3-4 times of lixiviate of the former medicine 1kg of Radix Apioris Fortunei (Radix Lespedezae Buergeri) ethanol 2 times, the supernatant of 2 extractions is mixed, and it is standby that recovery ethanol is made 1: 1 stock solution
Formulation components is as follows:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101442895A CN103381222A (en) | 2012-05-03 | 2012-05-03 | Plant radix-tetrastigmae gaseous preparation and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101442895A CN103381222A (en) | 2012-05-03 | 2012-05-03 | Plant radix-tetrastigmae gaseous preparation and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103381222A true CN103381222A (en) | 2013-11-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101442895A Pending CN103381222A (en) | 2012-05-03 | 2012-05-03 | Plant radix-tetrastigmae gaseous preparation and preparation method |
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| CN (1) | CN103381222A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793840A (en) * | 2019-03-13 | 2019-05-24 | 浙江理工大学 | Radix tetrastigme wound healing promoting cream and preparation method thereof |
| CN114569660A (en) * | 2022-03-21 | 2022-06-03 | 朱建国 | Radix tetrastigme spray for resisting bacteria and diminishing inflammation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723953A (en) * | 2005-07-08 | 2006-01-25 | 胡馨尹 | Herb medicine |
-
2012
- 2012-05-03 CN CN2012101442895A patent/CN103381222A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723953A (en) * | 2005-07-08 | 2006-01-25 | 胡馨尹 | Herb medicine |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793840A (en) * | 2019-03-13 | 2019-05-24 | 浙江理工大学 | Radix tetrastigme wound healing promoting cream and preparation method thereof |
| CN114569660A (en) * | 2022-03-21 | 2022-06-03 | 朱建国 | Radix tetrastigme spray for resisting bacteria and diminishing inflammation |
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| C05 | Deemed withdrawal (patent law before 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131106 |