CN100435801C - External use medicine for treating dermatosis and its preparing method - Google Patents
External use medicine for treating dermatosis and its preparing method Download PDFInfo
- Publication number
- CN100435801C CN100435801C CNB2006100221033A CN200610022103A CN100435801C CN 100435801 C CN100435801 C CN 100435801C CN B2006100221033 A CNB2006100221033 A CN B2006100221033A CN 200610022103 A CN200610022103 A CN 200610022103A CN 100435801 C CN100435801 C CN 100435801C
- Authority
- CN
- China
- Prior art keywords
- parts
- milligrams
- acetates
- aspirin
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention is to disclose a medicine of external use for treating skin disease And its preparation method, said medicine includes materials according to part by weight as follows: egocort 6-9 ; camphor 80-120;menthol 80-120;triamcinolone acetonaide acetate 8-12;carbamide 800-1200;aspirin 440-4400.
Description
(1) technical field:
The present invention relates to a kind of external used medicine, the dermopathic external used medicine of particularly a kind of treatment; The invention still further relates to the preparation method of the dermopathic external used medicine of this treatment.
(2) background technology:
Dermatosis is a kind of commonly encountered diseases, frequently-occurring disease clinically, also is the stubborn disease that is difficult to cure.During existing treatment is dermopathic, western drug is all a lot, for example application number is 02135863.x, name is called the Chinese invention patent of " ointment and the preparation method of treatment various skin disease ", a kind of ointment and preparation method for the treatment of the various skin disease disclosed, it is with the Chinese medicine Borneolum Syntheticum, Colophonium, Realgar, Plumbum preparatium, Alumen, Calomelas, Sublimated Sulphur etc., chloromycetin of western medicine, rifampicin, nystatins etc. are made medicated powder for raw material, with vaseline or pig Oleum sesami is that solvent is made ointment, be applied in skin surface, can treat dermatitis, beriberi, eczema, decubital ulcer, impetigo, various skin diseases such as scabies.And for example application number is: 95119650.2, name is called the Chinese invention patent of " medicine and the preparation method of treatment skin injury ", it discloses a kind of extracting solution by Chinese medicines such as Flos Lonicerae, Fructus Forsythiae, Radix Angelicae Sinensis, Nidus Vespae, Fructus Cnidii, Radix Paeoniae Rubra, Radix Scutellariae, Radix Salviae Miltiorrhizae, the Fructus Kochiae as the external preparation for skin medicine, this medicine can be eliminated skin surface antibacterial, virus, improve local blood circulation, make blood flow unobstructed, dermatosiss such as chloasma, senile plaque and neurodermatitis are had better therapeutic effect.But said medicine is to all not ideal enough by the therapeutic effect of fungus-caused various tineas.
(3) summary of the invention:
The present invention will disclose a kind of good effect, instant effect, the dermopathic external used medicine of treatment that cure rate is high; The present invention also will disclose the preparation method of the dermopathic external used medicine of this treatment.
Medicament selection dexamethasone acetate of the present invention, Camphora, Mentholum, triamcinolone acetonide acetate, carbamide, aspirin make up, make each medicine produce synergism, thereby can effectively treat by fungus-caused various tineas, the consumption of this each raw material of medicine is also groped to sum up to draw through the applicant in a large number, and each raw material consumption all has curative effect preferably in the following weight parts scope:
6～9 parts of dexamethasone acetates; 80～120 parts of Camphoras;
80～120 parts of Mentholums; 8～12 parts of triamcinolone acetonide acetates;
800～1200 parts in carbamide; 440～4400 parts of aspirin.
The preferable proportioning of above-mentioned each raw material is counted with weight portion:
7～8 parts of dexamethasone acetates; 95～105 parts of Camphoras;
95～105 parts of Mentholums; 9.5～10.5 parts of triamcinolone acetonide acetates;
950～1050 parts in carbamide; 1980～2420 parts of aspirin.
Each optimum proportion of materials is counted with weight portion:
7.5 parts of dexamethasone acetates; 100 parts of Camphoras;
100 parts of Mentholums; 10 parts of triamcinolone acetonide acetates;
1000 parts in carbamide; 2200 parts of aspirin.
In order to reach better therapeutic effect, the present invention also can add following raw material in weight portion on the basis of said medicine: 70～700 parts of 300～3000 parts of phenacetin and/or caffeine.
The comparatively preferred amount ranges of above-mentioned raw materials is (in a weight portion): 315～385 parts of 1350～1650 parts of phenacetin and/or caffeine.
Above-mentioned raw materials optimum amount scope is (in a weight portion): 350 parts of 1500 parts of phenacetin and/or caffeine.
The present invention treats dermopathic external used medicine and can adopt the conventional preparation method of medical external preparation to make various exterior-applied formulations, promptly weigh raw material by said ratio, mix homogeneously, add available adjuvant on the pharmaceutics required when preparing different dosage form, as add the adjuvant vaseline for preparing ointment, lanoline, paraffin etc., or the adjuvant carbomer of the logical gel of adding preparation bone, certainly also can add other adjuvant, be prepared into ointment by the conventional method of Western medicine external preparation, Emulsion, cream, gel, solution, tincture, spray, lotion, the exterior-applied formulation of various routines such as liniment.
The present invention treats dermopathic external used medicine also can adopt patent medicine dexamethasone acetate emulsifiable paste, Ledercort A urea cream, phenacetin+caffeine+aspirin preparation, wherein, the every gram of described compound dexamethason acetate emulsifiable paste contains 0.75 milligram of dexamethasone acetate, 10 milligrams of Camphoras, 10 milligrams of Mentholums; The every gram of described Ledercort A urea cream contains 1 milligram of triamcinolone acetonide acetate, 100 milligrams in carbamide; The every gram of described phenacetin+caffeine+aspirin contains 440 milligrams of aspirin, 300 milligrams of phenacetin, 70 milligrams of caffeine; Get above-mentioned compound dexamethason acetate emulsifiable paste 8～12 weight portions, Ledercort A urea cream 8～12 weight portions, phenacetin+caffeine+aspirin 1～10 weight portion, earlier phenacetin+caffeine+aspirin is pulverized, with above-mentioned each raw material mix homogeneously, obtain finished product again.
Preferably, the consumption of above-mentioned each raw material is: compound dexamethason acetate emulsifiable paste 9.5～10.5 weight portions, Ledercort A urea cream 9.5～10.5 weight portions, phenacetin+caffeine+aspirin 4.5～5.5 weight portions.
For reaching best therapeutic effect, should get compound dexamethason acetate emulsifiable paste 10 weight portions, Ledercort A urea cream 10 weight portions, phenacetin+caffeine+aspirin 5 weight portions.
It is formulated by dexamethasone acetate, Camphora, Mentholum, triamcinolone acetonide acetate, carbamide, aspirin etc. that the present invention treats dermopathic external used medicine, its scientific formulation is reasonable, have sterilization, antiinflammatory, antipruritic, repercussive effect, and its drug release absorbent properties are good, the drug effect performance is rapid, stable, onset time is fast, and 3～5 days can take effect; Every day, general medication was 2～3 times, during use, medicine directly embrocated in the affected part gets final product; Medicine of the present invention all has curative effect preferably to various skin diseases such as various dermatitis, eczemas, particularly to better by the therapeutic effect of various skin tinea such as fungus-caused psoriasis, the tinea manuum, tinea pedis, effective percentage is up to more than 80%, and it is easy to use, cheap, is a kind of safe and reliable external used medicine.
(4) specific embodiment:
Embodiment 1:
Get 9 milligrams of dexamethasone acetates, 80 milligrams of Camphoras, 80 milligrams of Mentholums, 12 milligrams of triamcinolone acetonide acetates, 1200 milligrams in carbamide, 4400 milligrams of aspirin, make the present invention by the conventional preparation method of ointment and treat dermopathic externally-applied ointment.
Embodiment 2:
Get 6 milligrams of dexamethasone acetates, 120 milligrams of Camphoras, 120 milligrams of Mentholums, 8 milligrams of triamcinolone acetonide acetates, 800 milligrams in carbamide, 2420 milligrams of aspirin, make the present invention by the conventional preparation method of externally used solution agent and treat dermopathic externally used solution agent.
Embodiment 3:
Get 7 milligrams of dexamethasone acetates, 95 milligrams of Camphoras, 105 milligrams of Mentholums, 10.5 milligrams of triamcinolone acetonide acetates, 1050 milligrams in carbamide, 1980 milligrams of aspirin, 700 milligrams of caffeine, make the present invention by the conventional preparation method of external-use tincture and treat dermopathic external-use tincture.
Embodiment 4:
Get 8 milligrams of dexamethasone acetates, 120 milligrams of Camphoras, 95 milligrams of Mentholums, 9.5 milligrams of triamcinolone acetonide acetates, 950 milligrams in carbamide, 440 milligrams of aspirin, 300 milligrams of phenacetin, make the present invention by the conventional preparation method of externally applied liniment and treat dermopathic externally applied liniment.
Embodiment 5:
Get 9 milligrams of dexamethasone acetates, 120 milligrams of Camphoras, 120 milligrams of Mentholums, 8 milligrams of triamcinolone acetonide acetates, 800 milligrams in carbamide, 2420 milligrams of aspirin, 3000 milligrams of caffeine, 70 milligrams of phenacetin, make the present invention by the conventional preparation method of ointment and treat dermopathic externally-applied ointment.
Embodiment 6:
Get 7.5 milligrams of dexamethasone acetates, 100 milligrams of Camphoras, 100 milligrams of Mentholums, 10 milligrams of triamcinolone acetonide acetates, 1000 milligrams in carbamide, 2200 milligrams of aspirin, 1500 milligrams of phenacetin, 350 milligrams of caffeine, make the present invention by the conventional preparation method of ointment and treat dermopathic externally-applied ointment.
Embodiment 7:
Get 10 of the phenacetin+caffeine+aspirins (0.5 gram/sheet) that " fishing woman " board Ledercort A urea cream that " He Jigong " board compound dexamethason acetate emulsifiable paste 10 restrains, peaceful Fengshan, Zhuhai pharmaceutical Co. Ltd produces 10 restrains, Wuhan Yuanda Pharmaceutical Group Co.,Ltd produces that Guangzhou Baiyunshan Hejigong Pharmaceutical Co., Ltd produces, earlier phenacetin+caffeine+aspirin is pulverized, with above-mentioned each raw material mix homogeneously, obtain finished product then; Wherein, the every gram of compound dexamethason acetate emulsifiable paste contains 0.75 milligram of dexamethasone acetate, 10 milligrams of Camphoras, 10 milligrams of Mentholums; The every gram of Ledercort A urea cream contains 1 milligram of triamcinolone acetonide acetate, 100 milligrams in carbamide; Every of phenacetin+caffeine+aspirin contains 220 milligrams of aspirin, 150 milligrams of phenacetin, 35 milligrams of caffeine.
Embodiment 8:
Get 20 of described compound dexamethason acetate emulsifiable pastes 8 grams of embodiment 7, embodiment 7 described Ledercort A urea creams 12 grams, embodiment 7 described phenacetin+caffeine+aspirins, mix homogeneously obtains finished product.
Embodiment 9:
Get 2 of described compound dexamethason acetate emulsifiable pastes 12 grams of embodiment 7, embodiment 7 described Ledercort A urea creams 8 grams, embodiment 7 described phenacetin+caffeine+aspirins, mix homogeneously obtains finished product.
Experimental example 1:
250 examples are carried out in the clinical pharmacology base, and (wherein test group is used embodiment 6 described ointment 50 examples, control group A is for using " along the peak " board clobetasol ointment 50 examples, " He Jigong " board compound dexamethason acetate emulsifiable paste 50 examples of matched group B for using Guangzhou Baiyunshan Hejigong Pharmaceutical Co., Ltd to produce, " fishing woman " board Ledercort A urea cream 50 examples of matched group C for using peaceful Fengshan, Zhuhai pharmaceutical Co. Ltd to produce, matched group D is for using comfort unguentum (composition is glycerol) 50 examples) clinical and experimental study.
Usage: directly ointment is embrocated in the affected part, 2 times on the one, used 20 days.
Clinical Comparison Study result is as follows:
| Title | Case | Total effective rate | Responding time |
| The test example | 50 | 86.2％ | 3～5 days |
| Control group A | 50 | 32.5％ | 7～10 days |
| Matched group B | 50 | 36.8％ | 7～10 days |
| Matched group C | 50 | 40.2％ | 7～10 days |
| Matched group D | 50 | 1％ | 20 days |
Embodiment 6 described ointment are 86.2% to the total effective rate of curing psoriasis, and responding time is 3～5 days, and both all obviously are better than control group A, and its effect also obviously is better than using separately compound dexamethason acetate emulsifiable paste or Ledercort A urea cream.And ointment of the present invention is not seen toxic and side effects and untoward reaction after 50 routine test group patient's medications, 50 examples are carried out safety inspection, and the contrast no abnormality seen changes before and after the medication, and is safe and reliable.
Claims (6)
1, the dermopathic external used medicine of a kind of treatment is characterized in that it comprises following raw material with weight portion:
6～9 parts of dexamethasone acetates; 80～120 parts of Camphoras;
80～120 parts of Mentholums; 8～12 parts of triamcinolone acetonide acetates;
800～1200 parts in carbamide; 440～4400 parts of aspirin.
2, the dermopathic external used medicine of treatment according to claim 1 is characterized in that each proportion of raw materials counts with weight portion:
7～8 parts of dexamethasone acetates; 95～105 parts of Camphoras;
95～105 parts of Mentholums; 9.5～10.5 parts of triamcinolone acetonide acetates;
950～1050 parts in carbamide; 1980～2420 parts of aspirin.
3, the dermopathic external used medicine of treatment according to claim 2 is characterized in that each proportion of raw materials counts with weight portion:
7.5 parts of dexamethasone acetates; 100 parts of Camphoras;
100 parts of Mentholums; 10 parts of triamcinolone acetonide acetates;
1000 parts in carbamide; 2200 parts of aspirin.
4, the dermopathic external used medicine of treatment according to claim 1 is characterized in that it also comprises following raw material in weight portion: 70～700 parts of 300～3000 parts of phenacetin and/or caffeine.
5, the dermopathic external used medicine of treatment according to claim 2 is characterized in that it also comprises following raw material in weight portion: 315～385 parts of 1350～1650 parts of phenacetin and/or caffeine.
6, the dermopathic external used medicine of treatment according to claim 3 is characterized in that it also comprises following raw material in weight portion: 350 parts of 1500 parts of phenacetin and/or caffeine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100221033A CN100435801C (en) | 2006-10-20 | 2006-10-20 | External use medicine for treating dermatosis and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100221033A CN100435801C (en) | 2006-10-20 | 2006-10-20 | External use medicine for treating dermatosis and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1943581A CN1943581A (en) | 2007-04-11 |
| CN100435801C true CN100435801C (en) | 2008-11-26 |
Family
ID=38043375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100221033A Expired - Fee Related CN100435801C (en) | 2006-10-20 | 2006-10-20 | External use medicine for treating dermatosis and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100435801C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406476B (en) * | 2007-10-11 | 2010-11-10 | 杨继荣 | Agent for treating skin peeling and allergy |
| CN103316077B (en) * | 2013-05-31 | 2014-10-15 | 徐莉梅 | Drug composition for sterilization and itching-relieving |
| CN105616426A (en) * | 2015-07-09 | 2016-06-01 | 广州白云山医药集团股份有限公司白云山何济公制药厂 | Compound dexamethasone acetate nano-cream and preparation method therefor |
| CN110327319A (en) * | 2019-07-10 | 2019-10-15 | 李建 | A kind of drug and preparation method thereof for treating neurodermatitis |
| CN110585183A (en) * | 2019-09-30 | 2019-12-20 | 潍坊市鸢飞大药房有限公司 | Liquid medicine for quickly treating chronic eczema and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262100A (en) * | 1999-01-29 | 2000-08-09 | 汪刘记 | Medicine for treating intractable tinea |
| CN1058866C (en) * | 1996-09-23 | 2000-11-29 | 牛德英 | Medicinal composition for treating tinea manus and pedis |
-
2006
- 2006-10-20 CN CNB2006100221033A patent/CN100435801C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058866C (en) * | 1996-09-23 | 2000-11-29 | 牛德英 | Medicinal composition for treating tinea manus and pedis |
| CN1262100A (en) * | 1999-01-29 | 2000-08-09 | 汪刘记 | Medicine for treating intractable tinea |
Non-Patent Citations (4)
| Title |
|---|
| 皮肤科常用外用药. 朱学骏.中国农村医学，第9期. 1990 |
| 皮肤科常用外用药. 朱学骏.中国农村医学，第9期. 1990 * |
| 薄层色谱法鉴别皮炎I号中醋酸地赛米松和醋酸曲安奈德. 周权等.药物分析杂志，第22卷第3期. 2002 |
| 薄层色谱法鉴别皮炎I号中醋酸地赛米松和醋酸曲安奈德. 周权等.药物分析杂志，第22卷第3期. 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1943581A (en) | 2007-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100435801C (en) | External use medicine for treating dermatosis and its preparing method | |
| CN105232725A (en) | Acne removing formulation and preparing method thereof | |
| CN102688327B (en) | Medicine composition of damp itch lotion and preparation method of medicine composition | |
| CN1943664B (en) | The Chinese traditional medicinal cream for treatment of eczema | |
| WO2012035478A2 (en) | Antifungal varnish composition | |
| CN101926857A (en) | Traditional Chinese medicinal liniment for treating vitiligo | |
| CN108434227A (en) | A kind of drug for treating tinea pedis | |
| CN104888056B (en) | A kind of externally applied anti-inflammation, care composition product and preparation technology thereof | |
| CN111375038B (en) | Traditional Chinese medicine bath composition for treating psoriasis as well as preparation method and application thereof | |
| WO2022047726A1 (en) | Traditional chinese medicine composition for treating dermatosis, preparation method therefor and use thereof | |
| CN114146051A (en) | Chinese medicinal gel for promoting granulation and healing ulcer, and its preparation method | |
| CN108721442B (en) | Traditional Chinese medicine composition and preparation for treating burns, scalds and diaper dermatitis and preparation method thereof | |
| CN101940544A (en) | Natural plant leg tickle nursing agent and preparation method thereof | |
| CN111358851A (en) | Gel for treating pet skin diseases and preparation method thereof | |
| CN110898151A (en) | A pharmaceutical composition for treating dermatophyte infection, and its preparation method | |
| CN103585330B (en) | A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof | |
| WO2019142042A1 (en) | Synergistic medicinal preparation for treating skin disorders like tinea versicolor | |
| CN109806321B (en) | A Chinese medicinal composition, its preparation method and application in preparing medicine for treating trauma | |
| CN107929346A (en) | Treat Chinese medicine composition of eczema and preparation method thereof | |
| CN107149641A (en) | A kind of composition for being used to treat burn and scald | |
| CN101468055A (en) | Gel patch for preventing and treating cerebral thrombosis and preparation method thereof | |
| CN101249140A (en) | Hair growth agent and method of preparing the same | |
| JP2004352680A (en) | Composition for treatment of allergic disease | |
| CN112220874A (en) | External traditional Chinese medicine composition and preparation method and application thereof | |
| CN105169326A (en) | Chilblain ointment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081126 Termination date: 20101020 |